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Entry version 208 (11 Dec 2019)
Sequence version 3 (20 Jun 2003)
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Protein

Integrin beta-PS

Gene

mys

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Integrin alpha-PS1/beta-PS is a receptor for laminin (PubMed:7972082). Integrin alpha-PS2/beta-PS is a receptor for Tig, wb and Ten-m (PubMed:7924982, PubMed:7972082, PubMed:9660786). Contributes to endodermal integrity and adhesion between the midgut epithelium and the surrounding visceral muscle (PubMed:15469969). Essential for migration of the primordial midgut cells and for maintaining, but not establishing, cell polarity in the midgut epithelium (PubMed:15469969). The two beta subunits mediate midgut migration by distinct mechanisms: beta-PS requires rhea/talin and Itgbn does not (PubMed:15469969). Required for rhea/talin correct cellular localization in the midgut (PubMed:15469969). Required for many embryonic (dorsal closure and somatic muscle attachments) and postembryonic developmental processes (attachment between cell layers of imaginal disks, organization of ommatidial arrays and flight muscle development) (PubMed:8119134, PubMed:7924982, PubMed:7972082, PubMed:10821184). Involved in the function and/or development of the olfactory system (PubMed:10821184). In the testes, essential for shv-dependent maintenance of somatic hub cells and their localization to the apical tip (PubMed:27191715). Plays a role in timely border cell migration during oogenesis (PubMed:19035354).8 Publications

Miscellaneous

The absence of the beta-PS subunit results in detachment and rounding up of the muscles, thus the gene encoding beta-PS is called myospheroid.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Integrin, Receptor
Biological processBehavior, Cell adhesion, Flight, Olfaction, Sensory transduction, Vision

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-114608 Platelet degranulation
R-DME-1236973 Cross-presentation of particulate exogenous antigens (phagosomes)
R-DME-1566977 Fibronectin matrix formation
R-DME-202733 Cell surface interactions at the vascular wall
R-DME-210991 Basigin interactions
R-DME-2129379 Molecules associated with elastic fibres
R-DME-216083 Integrin cell surface interactions
R-DME-3000170 Syndecan interactions
R-DME-3000178 ECM proteoglycans
R-DME-354192 Integrin alphaIIb beta3 signaling
R-DME-446107 Type I hemidesmosome assembly
R-DME-446343 Localization of the PINCH-ILK-PARVIN complex to focal adhesions
R-DME-5674135 MAP2K and MAPK activation
R-DME-6798695 Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Integrin beta-PS
Alternative name(s):
Position-specific antigen beta subunit
Protein myospheroid
Protein olfactory C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mys
Synonyms:l(1)mys, olfC
ORF Names:CG1560
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0004657 mys

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini24 – 776ExtracellularSequence analysisAdd BLAST753
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei777 – 799HelicalSequence analysisAdd BLAST23
Topological domaini800 – 846CytoplasmicSequence analysisAdd BLAST47

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

In zygotic mutant embryos, midgut forms primary constrictions but fails to elongate and the visceral muscle does not flatten but remains attached to the midgut epithelium. Embryos lacking maternal and zygotic mys show a delay in midgut migration. Mutant larvae present an olfactory phenotype, showing reduced response to isoamyl acetate but normal response to ethyl acetate.2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi807D → A: Rescues dorsal closure defect, muscle attachment defect, disorganized ommatidial array and loss of cell layer attachment in mutants; when associated with A-817. 1 Publication1
Mutagenesisi811F → A: Rescues muscle attachment defect and loss of cell layer attachment in mutants; when associated with A-814. 1 Publication1
Mutagenesisi814F → A: Rescues muscle attachment defect and loss of cell layer attachment in mutants; when associated with A-811. 1 Publication1
Mutagenesisi817E → A: Rescues dorsal closure defect, muscle attachment defects, disorganized ommatidial array and loss of cell layer attachment in mutants; when associated with A-807. 1 Publication1
Mutagenesisi831Y → A: No effect on lethality; when associated with A-843. 1 Publication1
Mutagenesisi843Y → A: No effect on lethality; when associated with A-831. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001635624 – 846Integrin beta-PSAdd BLAST823

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi46 ↔ 55By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi72N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi249 ↔ 252By similarity
Glycosylationi266N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi277N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi300 ↔ 341By similarity
Glycosylationi403N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi428N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi441 ↔ 453By similarity
Disulfide bondi473 ↔ 741By similarity
Disulfide bondi503 ↔ 507By similarity
Disulfide bondi522 ↔ 533By similarity
Disulfide bondi530 ↔ 571By similarity
Disulfide bondi535 ↔ 544By similarity
Disulfide bondi546 ↔ 561By similarity
Glycosylationi557N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi584 ↔ 599By similarity
Disulfide bondi601 ↔ 606By similarity
Glycosylationi603N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi622 ↔ 627By similarity
Disulfide bondi624 ↔ 656By similarity
Disulfide bondi629 ↔ 638By similarity
Disulfide bondi640 ↔ 647By similarity
Glycosylationi644N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi662 ↔ 667By similarity
Disulfide bondi664 ↔ 715By similarity
Disulfide bondi669 ↔ 682By similarity
Disulfide bondi685 ↔ 688By similarity
Disulfide bondi692 ↔ 701By similarity
Disulfide bondi698 ↔ 771By similarity
Glycosylationi718N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi719 ↔ 749By similarity
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei831PhosphotyrosineBy similarity1
Modified residuei843PhosphotyrosineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P11584

PRoteomics IDEntifications database

More...
PRIDEi
P11584

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P11584

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In ovaries, strongly expressed in follicle cells (PubMed:19035354). In oocytes, expressed in the forming dorsal appendages (at protein level) (PubMed:19035354). Expressed in the embryonic dorsal cuticle, the larval eye and the wing imaginal disk (PubMed:8119134). In testes, detected at the interface between somatic hub cells and cyst stem cells (PubMed:27191715).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0004657 Expressed in 41 organ(s), highest expression level in embryo

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P11584 differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P11584 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of an alpha and a beta subunit. Beta-PS associates with either alpha-PS1, alpha-PS2, alpha-PS3, alpha-PS4 or alpha-PS5.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
69357, 47 interactors

Protein interaction database and analysis system

More...
IntActi
P11584, 1 interactor

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0071061

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P11584

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini186 – 419VWFAAdd BLAST234
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati507 – 560IAdd BLAST54
Repeati561 – 605IIAdd BLAST45
Repeati606 – 646IIIAdd BLAST41
Repeati647 – 687IVAdd BLAST41

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni507 – 687Cysteine-rich tandem repeatsAdd BLAST181

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi115 – 143Ser-richAdd BLAST29

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the integrin beta chain family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1226 Eukaryota
ENOG410XP60 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P11584

KEGG Orthology (KO)

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KOi
K05719

Identification of Orthologs from Complete Genome Data

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OMAi
DEQMCTF

Database of Orthologous Groups

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OrthoDBi
473040at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P11584

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.410, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013111 EGF_extracell
IPR015812 Integrin_bsu
IPR014836 Integrin_bsu_cyt_dom
IPR012896 Integrin_bsu_tail
IPR036349 Integrin_bsu_tail_dom_sf
IPR002369 Integrin_bsu_VWA
IPR032695 Integrin_dom_sf
IPR036465 vWFA_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10082 PTHR10082, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07974 EGF_2, 1 hit
PF08725 Integrin_b_cyt, 1 hit
PF07965 Integrin_B_tail, 1 hit
PF00362 Integrin_beta, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002512 Integrin_B, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01186 INTEGRINB

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00187 INB, 1 hit
SM01241 Integrin_b_cyt, 1 hit
SM01242 Integrin_B_tail, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53300 SSF53300, 1 hit
SSF69179 SSF69179, 1 hit
SSF69687 SSF69687, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 1 hit
PS00243 INTEGRIN_BETA, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P11584-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MILERNRRCQ LALLMIAILA AIAGQTDAQK AAKLTAVSTC ASKEKCHTCI
60 70 80 90 100
QTEGCAWCMQ PDFKGQSRCY QNTSSLCPEE FAYSPITVEQ ILVNNKLTNQ
110 120 130 140 150
YKAELAAGGG GSAMSGSSSS SYSSSSSSSS FYSQSSSGSS SASGYEEYSA
160 170 180 190 200
GEIVQIQPQS MRLALRVNEK HNIKISYSQA EGYPVDLYYL MDLSKSMEDD
210 220 230 240 250
KAKLSTLGDK LSETMKRITN NFHLGFGSFV DKVLMPYVST IPKKLEHPCE
260 270 280 290 300
NCKAPYGYQN HMPLNNNTES FSNEVKNATV SGNLDAPEGG FDAIMQAIAC
310 320 330 340 350
RSQIGWREQA RRLLVFSTDA GFHYAGDGKL GGVIAPNDGE CHLSPKGEYT
360 370 380 390 400
HSTLQDYPSI SQINQKVKDN AINIIFAVTA SQLSVYEKLV EHIQGSSAAK
410 420 430 440 450
LDNDSSNVVE LVKEEYRKIS SSVEMKDNAT GDVKITYFSS CLSNGPEVQT
460 470 480 490 500
SKCDNLKEGQ QVSFTAQIQL LKCPEDPRDW TQTIHISPVG INEVMQIQLT
510 520 530 540 550
MLCSCPCENP GSIGYQVQAN SCSGHGTSMC GICNCDDSYF GNKCECSATD
560 570 580 590 600
LTSKFANDTS CRADSTSTTD CSGRGHCVCG ACECHKRPNP IEIISGKHCE
610 620 630 640 650
CDNFSCERNR NQLCSGPDHG TCECGRCKCK PGWTGSNCGC QESNDTCMPP
660 670 680 690 700
GGGEICSGHG TCECGVCKCT VNDQGRFSGR HCEKCPTCSG RCQELKDCVQ
710 720 730 740 750
CQMYKTGELK NGDDCARNCT QFVPVGVEKV EIDETKDEQM CKFFDEDDCK
760 770 780 790 800
FMFKYSEQGE LHVYAQENKE CPAKVFMLGI VMGVIAAIVL VGLAILLLWK
810 820 830 840
LLTTIHDRRE FARFEKERMN AKWDTGENPI YKQATSTFKN PMYAGK
Length:846
Mass (Da):92,656
Last modified:June 20, 2003 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3618C74FA1B99AFB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X2JAU0X2JAU0_DROME
Integrin beta
mys b[[PS]], beta integrin, beta-Int, beta-int, beta-integrin
846Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X2JE30X2JE30_DROME
Integrin beta
mys b[[PS]], beta integrin, beta-Int, beta-int, beta-integrin
846Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti18I → M in AAA28714 (PubMed:3128792).Curated1
Sequence conflicti24G → A in AAA28714 (PubMed:3128792).Curated1
Sequence conflicti27D → N in AAA28714 (PubMed:3128792).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
J03251 mRNA Translation: AAA28714.1
AE014298 Genomic DNA Translation: AAF46313.2
AY113499 mRNA Translation: AAM29504.1

Protein sequence database of the Protein Information Resource

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PIRi
A30889

NCBI Reference Sequences

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RefSeqi
NP_001284998.1, NM_001298069.1
NP_001284999.1, NM_001298070.1
NP_524793.2, NM_080054.3

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0071105; FBpp0071061; FBgn0004657
FBtr0340136; FBpp0309122; FBgn0004657
FBtr0340137; FBpp0309123; FBgn0004657

Database of genes from NCBI RefSeq genomes

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GeneIDi
44885

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG1560

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03251 mRNA Translation: AAA28714.1
AE014298 Genomic DNA Translation: AAF46313.2
AY113499 mRNA Translation: AAM29504.1
PIRiA30889
RefSeqiNP_001284998.1, NM_001298069.1
NP_001284999.1, NM_001298070.1
NP_524793.2, NM_080054.3

3D structure databases

SMRiP11584
ModBaseiSearch...

Protein-protein interaction databases

BioGridi69357, 47 interactors
IntActiP11584, 1 interactor
STRINGi7227.FBpp0071061

PTM databases

iPTMnetiP11584

Proteomic databases

PaxDbiP11584
PRIDEiP11584

Genome annotation databases

EnsemblMetazoaiFBtr0071105; FBpp0071061; FBgn0004657
FBtr0340136; FBpp0309122; FBgn0004657
FBtr0340137; FBpp0309123; FBgn0004657
GeneIDi44885
KEGGidme:Dmel_CG1560

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
44885
FlyBaseiFBgn0004657 mys

Phylogenomic databases

eggNOGiKOG1226 Eukaryota
ENOG410XP60 LUCA
InParanoidiP11584
KOiK05719
OMAiDEQMCTF
OrthoDBi473040at2759
PhylomeDBiP11584

Enzyme and pathway databases

ReactomeiR-DME-114608 Platelet degranulation
R-DME-1236973 Cross-presentation of particulate exogenous antigens (phagosomes)
R-DME-1566977 Fibronectin matrix formation
R-DME-202733 Cell surface interactions at the vascular wall
R-DME-210991 Basigin interactions
R-DME-2129379 Molecules associated with elastic fibres
R-DME-216083 Integrin cell surface interactions
R-DME-3000170 Syndecan interactions
R-DME-3000178 ECM proteoglycans
R-DME-354192 Integrin alphaIIb beta3 signaling
R-DME-446107 Type I hemidesmosome assembly
R-DME-446343 Localization of the PINCH-ILK-PARVIN complex to focal adhesions
R-DME-5674135 MAP2K and MAPK activation
R-DME-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
mys fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
44885

Protein Ontology

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PROi
PR:P11584

Gene expression databases

BgeeiFBgn0004657 Expressed in 41 organ(s), highest expression level in embryo
ExpressionAtlasiP11584 differential
GenevisibleiP11584 DM

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR013111 EGF_extracell
IPR015812 Integrin_bsu
IPR014836 Integrin_bsu_cyt_dom
IPR012896 Integrin_bsu_tail
IPR036349 Integrin_bsu_tail_dom_sf
IPR002369 Integrin_bsu_VWA
IPR032695 Integrin_dom_sf
IPR036465 vWFA_dom_sf
PANTHERiPTHR10082 PTHR10082, 1 hit
PfamiView protein in Pfam
PF07974 EGF_2, 1 hit
PF08725 Integrin_b_cyt, 1 hit
PF07965 Integrin_B_tail, 1 hit
PF00362 Integrin_beta, 1 hit
PIRSFiPIRSF002512 Integrin_B, 1 hit
PRINTSiPR01186 INTEGRINB
SMARTiView protein in SMART
SM00187 INB, 1 hit
SM01241 Integrin_b_cyt, 1 hit
SM01242 Integrin_B_tail, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF69179 SSF69179, 1 hit
SSF69687 SSF69687, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 1 hit
PS00243 INTEGRIN_BETA, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiITBX_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P11584
Secondary accession number(s): Q8MYX9, Q9W3L2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: June 20, 2003
Last modified: December 11, 2019
This is version 208 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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