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Entry version 149 (12 Aug 2020)
Sequence version 4 (25 Oct 2017)
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Protein

L-fuculokinase

Gene

fucK

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the phosphorylation of L-fuculose. Can also phosphorylate, with lower efficiency, D-ribulose, D-xylulose and D-fructose.UniRule annotation1 Publication

Caution

A 10-residue longer version of this protein (starting with the sequence MLSGYIAGAI) has been identified in strain W3110 (PubMed:9740056). Other evidence, including ribosomal profiling and comparison with other bacterial genera, suggests this protein actually starts on the indicated Met codon (PubMed:25078267).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

a divalent metal cationUniRule annotation1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>pH dependencei

Optimum pH is 7.8.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-fucose degradation

This protein is involved in step 2 of the subpathway that synthesizes L-lactaldehyde and glycerone phosphate from L-fucose.UniRule annotation1 Publication
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. L-fucose isomerase (fucI), L-fucose isomerase (fucI)
  2. L-fuculokinase (fucK), L-fuculokinase (fucK)
  3. L-fuculose phosphate aldolase (fucA), L-fuculose phosphate aldolase (fucA), L-fuculose phosphate aldolase (fucA)
This subpathway is part of the pathway L-fucose degradation, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-lactaldehyde and glycerone phosphate from L-fucose, the pathway L-fucose degradation and in Carbohydrate degradation.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-UniRule
  • L-fuculokinase activity Source: EcoCyc

GO - Biological processi

  • D-arabinose catabolic process Source: EcoCyc
  • L-fucose catabolic process Source: EcoCyc
  • rhamnose catabolic process Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
Biological processCarbohydrate metabolism, Fucose metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:FUCULOKIN-MONOMER
ECOL316407:JW2774-MONOMER
MetaCyc:FUCULOKIN-MONOMER

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00563;UER00625

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
L-fuculokinaseUniRule annotation (EC:2.7.1.51UniRule annotation)
Alternative name(s):
L-fuculose kinaseUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:fucKUniRule annotation
Ordered Locus Names:b2803, JW2774
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000594231 – 472L-fuculokinaseAdd BLAST472

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P11553

PRoteomics IDEntifications database

More...
PRIDEi
P11553

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...
SWISS-2DPAGEi
P11553

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
4259225, 22 interactors
850383, 1 interactor

Database of interacting proteins

More...
DIPi
DIP-9712N

Protein interaction database and analysis system

More...
IntActi
P11553, 4 interactors

STRING: functional protein association networks

More...
STRINGi
511145.b2803

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P11553

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FGGY kinase family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG1070, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009281_11_2_6

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P11553

KEGG Orthology (KO)

More...
KOi
K00879

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P11553

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_00986, Fuculokinase, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR043129, ATPase_NBD
IPR000577, Carb_kinase_FGGY
IPR018485, Carb_kinase_FGGY_C
IPR018483, Carb_kinase_FGGY_CS
IPR018484, Carb_kinase_FGGY_N
IPR013450, Fuculokinase

The PANTHER Classification System

More...
PANTHERi
PTHR10196:SF60, PTHR10196:SF60, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02782, FGGY_C, 1 hit
PF00370, FGGY_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000538, GlpK, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53067, SSF53067, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02628, fuculo_kin_coli, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00933, FGGY_KINASES_1, 1 hit
PS00445, FGGY_KINASES_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P11553-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKQEVILVLD CGATNVRAIA VNRQGKIVAR ASTPNASDIA MENNTWHQWS
60 70 80 90 100
LDAILQRFAD CCRQINSELT ECHIRGIAVT TFGVDGALVD KQGNLLYPII
110 120 130 140 150
SWKCPRTAAV MDNIERLISA QRLQAISGVG AFSFNTLYKL VWLKENHPQL
160 170 180 190 200
LERAHAWLFI SSLINHRLTG EFTTDITMAG TSQMLDIQQR DFSPQILQAT
210 220 230 240 250
GIPRRLFPRL VEAGEQIGTL QNSAAAMLGL PVGIPVISAG HDTQFALFGA
260 270 280 290 300
GAEQNEPVLS SGTWEILMVR SAQVDTSLLS QYAGSTCELD SQAGLYNPGM
310 320 330 340 350
QWLASGVLEW VRKLFWTAET PWQMLIEEAR LIAPGADGVK MQCDLLSCQN
360 370 380 390 400
AGWQGVTLNT TRGHFYRAAL EGLTAQLQRN LQMLEKIGHF KASELLLVGG
410 420 430 440 450
GSRNTLWNQI KANMLDIPVK VLDDAETTVA GAALFGWYGV GEFNSPEEAR
460 470
AQIHYQYRYF YPQTEPEFIE EV
Length:472
Mass (Da):52,259
Last modified:October 25, 2017 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE09BB640495D7A3D
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB40453 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAE76875 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence CAA33128 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X15025 Genomic DNA Translation: CAA33128.1 Different initiation.
U29581 Genomic DNA Translation: AAB40453.1 Different initiation.
U00096 Genomic DNA Translation: AAC75845.2
AP009048 Genomic DNA Translation: BAE76875.1 Different initiation.

Protein sequence database of the Protein Information Resource

More...
PIRi
JS0186, KIECFK

NCBI Reference Sequences

More...
RefSeqi
NP_417283.2, NC_000913.3
WP_000808392.1, NZ_LN832404.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC75845; AAC75845; b2803
BAE76875; BAE76875; BAE76875

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
946022

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW2774
eco:b2803

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|511145.12.peg.2903

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15025 Genomic DNA Translation: CAA33128.1 Different initiation.
U29581 Genomic DNA Translation: AAB40453.1 Different initiation.
U00096 Genomic DNA Translation: AAC75845.2
AP009048 Genomic DNA Translation: BAE76875.1 Different initiation.
PIRiJS0186, KIECFK
RefSeqiNP_417283.2, NC_000913.3
WP_000808392.1, NZ_LN832404.1

3D structure databases

SMRiP11553
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi4259225, 22 interactors
850383, 1 interactor
DIPiDIP-9712N
IntActiP11553, 4 interactors
STRINGi511145.b2803

2D gel databases

SWISS-2DPAGEiP11553

Proteomic databases

PaxDbiP11553
PRIDEiP11553

Genome annotation databases

EnsemblBacteriaiAAC75845; AAC75845; b2803
BAE76875; BAE76875; BAE76875
GeneIDi946022
KEGGiecj:JW2774
eco:b2803
PATRICifig|511145.12.peg.2903

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB0346

Phylogenomic databases

eggNOGiCOG1070, Bacteria
HOGENOMiCLU_009281_11_2_6
InParanoidiP11553
KOiK00879
PhylomeDBiP11553

Enzyme and pathway databases

UniPathwayiUPA00563;UER00625
BioCyciEcoCyc:FUCULOKIN-MONOMER
ECOL316407:JW2774-MONOMER
MetaCyc:FUCULOKIN-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P11553

Family and domain databases

HAMAPiMF_00986, Fuculokinase, 1 hit
InterProiView protein in InterPro
IPR043129, ATPase_NBD
IPR000577, Carb_kinase_FGGY
IPR018485, Carb_kinase_FGGY_C
IPR018483, Carb_kinase_FGGY_CS
IPR018484, Carb_kinase_FGGY_N
IPR013450, Fuculokinase
PANTHERiPTHR10196:SF60, PTHR10196:SF60, 1 hit
PfamiView protein in Pfam
PF02782, FGGY_C, 1 hit
PF00370, FGGY_N, 1 hit
PIRSFiPIRSF000538, GlpK, 1 hit
SUPFAMiSSF53067, SSF53067, 2 hits
TIGRFAMsiTIGR02628, fuculo_kin_coli, 1 hit
PROSITEiView protein in PROSITE
PS00933, FGGY_KINASES_1, 1 hit
PS00445, FGGY_KINASES_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFUCK_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P11553
Secondary accession number(s): Q2MA31
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 25, 2017
Last modified: August 12, 2020
This is version 149 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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