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Entry version 135 (16 Jan 2019)
Sequence version 1 (01 Oct 1989)
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Protein

Dystrophin

Gene

DMD

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in anchoring the cytoskeleton to the plasma membrane.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri3304 – 3351ZZ-typePROSITE-ProRule annotationAdd BLAST48

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding
LigandCalcium, Metal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dystrophin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DMD
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Postsynaptic cell membrane, Synapse

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000760781 – 3660DystrophinAdd BLAST3660

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P11533

PRoteomics IDEntifications database

More...
PRIDEi
P11533

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9031.ENSGALP00000026200

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P11533

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P11533

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini19 – 123Calponin-homology (CH) 1PROSITE-ProRule annotationAdd BLAST105
Domaini138 – 244Calponin-homology (CH) 2PROSITE-ProRule annotationAdd BLAST107
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati341 – 449Spectrin 1Add BLAST109
Repeati450 – 558Spectrin 2Add BLAST109
Repeati561 – 669Spectrin 3Add BLAST109
Repeati721 – 830Spectrin 4Add BLAST110
Repeati832 – 936Spectrin 5Add BLAST105
Repeati945 – 1047Spectrin 6Add BLAST103
Repeati1050 – 1156Spectrin 7Add BLAST107
Repeati1159 – 1265Spectrin 8Add BLAST107
Repeati1268 – 1369Spectrin 9Add BLAST102
Repeati1470 – 1570Spectrin 10Add BLAST101
Repeati1573 – 1678Spectrin 11Add BLAST106
Repeati1681 – 1782Spectrin 12Add BLAST102
Repeati1879 – 1981Spectrin 13Add BLAST103
Repeati2013 – 2103Spectrin 14Add BLAST91
Repeati2106 – 2211Spectrin 15Add BLAST106
Repeati2214 – 2321Spectrin 16Add BLAST108
Repeati2472 – 2574Spectrin 17Add BLAST103
Repeati2577 – 2683Spectrin 18Add BLAST107
Repeati2686 – 2799Spectrin 19Add BLAST114
Repeati2802 – 2904Spectrin 20Add BLAST103
Repeati2906 – 2928Spectrin 21Add BLAST23
Repeati2931 – 3037Spectrin 22Add BLAST107
Domaini3052 – 3085WWPROSITE-ProRule annotationAdd BLAST34

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 244Actin-bindingAdd BLAST244

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri3304 – 3351ZZ-typePROSITE-ProRule annotationAdd BLAST48

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4286 Eukaryota
COG5069 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231173

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG005495

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P11533

KEGG Orthology (KO)

More...
KOi
K10366

Database of Orthologous Groups

More...
OrthoDBi
72477at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P11533

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014 CH, 2 hits
cd00201 WW, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR016344 Dystrophin
IPR035436 Dystrophin/utrophin
IPR011992 EF-hand-dom_pair
IPR015153 EF-hand_dom_typ1
IPR015154 EF-hand_dom_typ2
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat
IPR001202 WW_dom
IPR036020 WW_dom_sf
IPR000433 Znf_ZZ

The PANTHER Classification System

More...
PANTHERi
PTHR44318:SF1 PTHR44318:SF1, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307 CH, 2 hits
PF09068 EF-hand_2, 1 hit
PF09069 EF-hand_3, 1 hit
PF00435 Spectrin, 17 hits
PF00397 WW, 1 hit
PF00569 ZZ, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002341 Dystrophin/utrophin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033 CH, 2 hits
SM00150 SPEC, 21 hits
SM00456 WW, 1 hit
SM00291 ZnF_ZZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473 SSF47473, 2 hits
SSF47576 SSF47576, 1 hit
SSF51045 SSF51045, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 1 hit
PS01357 ZF_ZZ_1, 1 hit
PS50135 ZF_ZZ_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P11533-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAHVLWYEE VEDDYEREDV QKKTFTKWIN AQFAKCGRRC IEDLFNDFRD
60 70 80 90 100
GRKLLELLEC LTGQKIAKEK GSTRVHALNN VNKALQILQR NNVDLVNIGS
110 120 130 140 150
SDIVDGNHKL TLGLIWNIIL HWQVKDVMKN IMAGLQQTNS EKILLSWVRQ
160 170 180 190 200
STRNYPQVNV INFTSSWSDG LAFNALLHSH RPDLFDWNAV ASQQSPVQRL
210 220 230 240 250
DHAFNIARQH LGIEKLLDPE DVATACPDKK SILMYVTSLF QVLPQQVTME
260 270 280 290 300
AIREVEMLPR HSRVTTEEHI QVHHQQHFSQ EITVNIPQRP SPSPKPRFKS
310 320 330 340 350
YAYAQTAYVI PPDQKRRQVP PQFLETVEKR TYTTTVMRSE MDLDSYQTAL
360 370 380 390 400
EEVLTWLLSA EDALQAQGDI SSDVEVVKEQ FHTHEGFMME LTAHQGRVGN
410 420 430 440 450
VLQVGSQLLA MGKLSDDEEN EIQEQMNLLN SRWESLRVAS MEKQSNLHKI
460 470 480 490 500
LMDLQNQQLA QLADWLTKTE ERTKKIDSEP LGPDLEDLKR QVEEHKAFQD
510 520 530 540 550
DLEQEQVKVN SLTHMVVVVD ENSGDKATAA LEEQLQHFGS RWAAICRWTE
560 570 580 590 600
DRWVLLQDIL RKWQHFAEEQ CLFDAWLTEK EGSLSKIQTS DFKDENEMLT
610 620 630 640 650
SLRKLAILKG DIEMKKQMMS KLKSLSRDLL VAVKNKAVAQ KLESRLENFA
660 670 680 690 700
QRWDSLVQKL ESDSKQVSQA VTTTQTSLTQ TTVMETVTMV TTREQILVKH
710 720 730 740 750
AKEELPPPPP HKKRQLLVDS EIRKRFDSDT TELHSWMTRS EAVLQSPEFA
760 770 780 790 800
IYRKEGNLSD LRERVNAIQR EKPEKYRKLQ DASRSAEALV EQMVNEGLNA
810 820 830 840 850
DNIRQASEQL KSRWIEFCQL LSERLVWLEY QNSIIDFYSQ LQRLEQTAIT
860 870 880 890 900
AENWLKAQPT PATDPATVKI QLEKCKDEII RMSTLQPQIE RLKAQSQALK
910 920 930 940 950
EKEQCPVFLD ADLAAFTSHF KQILADMHTR EKQLQTIFDS LPPARYKDTV
960 970 980 990 1000
TTILSWIQQS ETKVSIPPVA VAEYEIMEQR LGELKALQSS LQEQQKGLKY
1010 1020 1030 1040 1050
LNTTVEDLSR KAPAEVSQKY RSEVELIVGR WKKLSSQLVE HCQKLEDLMT
1060 1070 1080 1090 1100
KLQRFQNDTK TLKKWMAEVD VFLKEEWPAL GDSEALEKQL EQCTALVNDI
1110 1120 1130 1140 1150
QTIQPSLNSV NEIGKKMKRE AEPEFASRIA TELKDLNAQW EHICQQAHAK
1160 1170 1180 1190 1200
KAALKGGLDK TVSLRKDLSE MHEWITQAEE EYLERDFEYK TPEELQKAVE
1210 1220 1230 1240 1250
ELKRAKEDAM QKEVKVKLIT DSVNNFIAKA PPAANEALKK ELDVLITSYQ
1260 1270 1280 1290 1300
RLCSRLNGKC KTLEEVWACW HELLSYLDAE NKWLNEVELK LKATENIQGG
1310 1320 1330 1340 1350
AEEISESLDS LERLMRHPED NRNQIRELAQ TLTDGGILDE LINEKLEKFN
1360 1370 1380 1390 1400
TRWEELQQEA VRRQKSLEQS IQSAQETDKT LRLIQESLAA IDKQLTAYTA
1410 1420 1430 1440 1450
DRVDAAQVPQ EAQKIQSELT SHEISLEEMK KRNRGKESAK RVLSQIDVAQ
1460 1470 1480 1490 1500
KKLQDVSMKF RLFQKPANFE QRLQECKRIL DEVKLQVPKL ETKSVEQEVV
1510 1520 1530 1540 1550
QSHLDHCMKL YKSLSEVKSE VETVIKTGRQ IVQKQQTENP KELDERLTAL
1560 1570 1580 1590 1600
KLQYNELGAK VTEKKQELEK CLKLSRKLRK EINSLTEWLA ATDVELTKRS
1610 1620 1630 1640 1650
AVQGMPSNLD AEIAWGKATR KEIEKRQVQL KNICDLGENL KTVLKGKESL
1660 1670 1680 1690 1700
VEDKLSLLNS NWIAVTSRAE EWLNLLMEYQ KHMEAFDQKV ANVTTWIYRA
1710 1720 1730 1740 1750
EILLDESDKQ KPQQKEETLK RLKAELNDMH PKVDSVRDQA VDLMTNRGDH
1760 1770 1780 1790 1800
CRKVIEPKLS ELNHRFAAIS QRIKSGKPFI PLKELEQFDF DIQKLLEPLE
1810 1820 1830 1840 1850
VEIQQGVNLK EEDFNKDMSE DDESTVKELL QRGDTLQKRI TDERKREEIK
1860 1870 1880 1890 1900
IKQQLLQTKH NALKDLRSQR RKKALEISHQ WYQYKRQADD LMTWLDDIEK
1910 1920 1930 1940 1950
KLASLPDHKD EQKLKEIGGE LEKKKEDLNA VNRQAERLSK DGAAKAVEPT
1960 1970 1980 1990 2000
LVQLSKRWRD FESKFAQFRR LNYAQIQTVL EDTTFVMTES MTVETTYVPS
2010 2020 2030 2040 2050
TYLAEILQLL QALSEVEERL NSPVLQAKDC EDLLKQEECL KNIKDCLGRL
2060 2070 2080 2090 2100
QGHIDIIHSK KTPALQSATP RETANIQDKL TQLNSQWEKV NKMYRDRQAR
2110 2120 2130 2140 2150
FDKSKEKWRL FHCEMKSFNE WLTETEEKLS RAQIEAGDVG HVKTKQFLQE
2160 2170 2180 2190 2200
LQDGIGRQQT VVKTLNVTGE EIIEQSSAAD ANVLKEQLGN LNTRWQEICR
2210 2220 2230 2240 2250
QLVEKRKRIE EEKNILSEFQ EDLNKLILWL EETENVIAIP LEPGNEDQLR
2260 2270 2280 2290 2300
DCLGKVKLRV EELLPHKGIL KRLNETGGTT LGSASLNPER KHKLESTLKE
2310 2320 2330 2340 2350
ASRRLLKVSR DLPEKQKEIE ILLKDFIELN QQINQLTLWI TPVKNQLELY
2360 2370 2380 2390 2400
NQVGQPGAFD IKETEAAVQA KQPNVEEVLS KGCHLYKEKP ATHPVKKKLE
2410 2420 2430 2440 2450
DLNADWKAIN HLILQLKEKP TFGEPALTSP GVLTSGQTVA VDTQARVTKE
2460 2470 2480 2490 2500
TTSFTPEMPS SVLLEVPALA DFNKAWAELT DWLSRLDREI KAQRVTVGDL
2510 2520 2530 2540 2550
DDINDMIIKQ KANMQDLEQR RPQLDELITA AQNLKNKTSN QEARTIITDR
2560 2570 2580 2590 2600
IEKIQSQWDD VHGYLQNRRQ QLHEMQKDST QWLEAKQEAE QVLEQAKAKL
2610 2620 2630 2640 2650
ESWKEISYTV EALKKQNSEL KQFSKEIRQW QMNIEGVNDV ALKPVRDYSA
2660 2670 2680 2690 2700
DDTRKVELMT DNINATWATI NKRVSEREAA LESALLMLQE FYLDLEKFLA
2710 2720 2730 2740 2750
WLTEAETTAN VLQDATHKEK TLEDPQMVRE LMKQWQDLQA EIDAHTDIFH
2760 2770 2780 2790 2800
NLDENGQKIL RSLEGSEDAV LLQRRLDNMN FRWSELRKKS LNIRSHLEAS
2810 2820 2830 2840 2850
TDQWKRLHLS LQELLAWLQL KEDELKQQAP IGGDIPTVQK QNDVHRTFKR
2860 2870 2880 2890 2900
ELKTKEPVIM NALETVRLFL ADQPVEGLEK VYPEPRDLSP EERAQNVTKV
2910 2920 2930 2940 2950
LRRQADDVRT EWDKLNLRSA DWQKKIDDAL ERLQGLQEAM DELDLKLRQA
2960 2970 2980 2990 3000
EAFKGSWQPV GDLLIDSLQD HLEKVKVYRA EMVPLKEKVH QVNELAHRFA
3010 3020 3030 3040 3050
PPDIQLSPYT LSCLEDLNTR WKVLQVAIDE RIRQLHEAHR DFGPTSQHFL
3060 3070 3080 3090 3100
TTSVQGPWER AISPNKVPYY INHETQTTCW DHPKMTELYQ SLADLNNVRF
3110 3120 3130 3140 3150
SAYRTAMKLR RLQKALCLDL LNLSAACDAL DQHNLKQNDQ PMDILQIINC
3160 3170 3180 3190 3200
LTTIYDRLEQ EHNNLVNVPL CVDMCLNWLL NVYDTGRTGR IRVLSFKTGV
3210 3220 3230 3240 3250
VSLCKAHLED KYRYLFKQVA SSTGFCDQRR LGLLLHDSIQ IPRQLGEVAS
3260 3270 3280 3290 3300
FGGSNIEPSV RSCFQFANNK PEIEAALFLD WMRLEPQSMV WLPVLHRVAA
3310 3320 3330 3340 3350
AETAKHQAKC NICKECPIIG FRYRSLKHFN YDICQSCFFS GRVAKGHKMH
3360 3370 3380 3390 3400
YPMVEYCTPT TSGEDVRDFA KVLKNKFRTK RYFAKHPRMG YLPVQTVLEG
3410 3420 3430 3440 3450
DNMETPVTLI NFWPVDSALA EMENSNGSYL NDSISPNESI DDEHLLIQHY
3460 3470 3480 3490 3500
CQSLNQESPL SQPRSPAQIL ISLESEERGE LERILADLEE ENRNLQAEYD
3510 3520 3530 3540 3550
RLKQQHDHKG LSPLPSPPEM MPVSPQSPRD AELIAEAKLL RQHKGRLEAR
3560 3570 3580 3590 3600
MQILEDHNKQ LESQLHRLRQ LLEQPQADAK VNGTTLSSPS TSLQRSDSSQ
3610 3620 3630 3640 3650
PMLLRVVGSQ TSETMGEDDL LSPPQDTSTG LEEVMEQLNN SFPSSRGRNA
3660
PGKPVREATM
Length:3,660
Mass (Da):422,881
Last modified:October 1, 1989 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i85493DAF6D5B6D4A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti1171Missing . 1
Natural varianti1869Q → H. 1
Natural varianti1885K → R. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X13369 mRNA Translation: CAA31746.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S02041

NCBI Reference Sequences

More...
RefSeqi
NP_990630.2, NM_205299.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Gga.718

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
396236

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
gga:396236

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13369 mRNA Translation: CAA31746.1
PIRiS02041
RefSeqiNP_990630.2, NM_205299.2
UniGeneiGga.718

3D structure databases

ProteinModelPortaliP11533
SMRiP11533
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000026200

Proteomic databases

PaxDbiP11533
PRIDEiP11533

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396236
KEGGigga:396236

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
1756

Phylogenomic databases

eggNOGiKOG4286 Eukaryota
COG5069 LUCA
HOGENOMiHOG000231173
HOVERGENiHBG005495
InParanoidiP11533
KOiK10366
OrthoDBi72477at2759
PhylomeDBiP11533

Miscellaneous databases

Protein Ontology

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PROi
PR:P11533

Family and domain databases

CDDicd00014 CH, 2 hits
cd00201 WW, 1 hit
Gene3Di1.10.418.10, 2 hits
InterProiView protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR016344 Dystrophin
IPR035436 Dystrophin/utrophin
IPR011992 EF-hand-dom_pair
IPR015153 EF-hand_dom_typ1
IPR015154 EF-hand_dom_typ2
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat
IPR001202 WW_dom
IPR036020 WW_dom_sf
IPR000433 Znf_ZZ
PANTHERiPTHR44318:SF1 PTHR44318:SF1, 1 hit
PfamiView protein in Pfam
PF00307 CH, 2 hits
PF09068 EF-hand_2, 1 hit
PF09069 EF-hand_3, 1 hit
PF00435 Spectrin, 17 hits
PF00397 WW, 1 hit
PF00569 ZZ, 1 hit
PIRSFiPIRSF002341 Dystrophin/utrophin, 1 hit
SMARTiView protein in SMART
SM00033 CH, 2 hits
SM00150 SPEC, 21 hits
SM00456 WW, 1 hit
SM00291 ZnF_ZZ, 1 hit
SUPFAMiSSF47473 SSF47473, 2 hits
SSF47576 SSF47576, 1 hit
SSF51045 SSF51045, 1 hit
PROSITEiView protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 1 hit
PS01357 ZF_ZZ_1, 1 hit
PS50135 ZF_ZZ_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDMD_CHICK
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P11533
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: January 16, 2019
This is version 135 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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