UniProtKB - P11531 (DMD_MOUSE)
Dystrophin
Dmd
Functioni
Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission.
1 PublicationSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 3306 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 3309 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 3330 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 3333 | ZincPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 3301 – 3357 | ZZ-type; degeneratePROSITE-ProRule annotationAdd BLAST | 57 |
GO - Molecular functioni
- actin binding Source: MGI
- actin filament binding Source: GO_Central
- dystroglycan binding Source: MGI
- integrin binding Source: MGI
- lamin binding Source: MGI
- myosin binding Source: MGI
- nitric-oxide synthase binding Source: BHF-UCL
- PDZ domain binding Source: MGI
- protein-containing complex binding Source: MGI
- structural constituent of muscle Source: MGI
- vinculin binding Source: MGI
- zinc ion binding Source: InterPro
GO - Biological processi
- actin cytoskeleton organization Source: GO_Central
- aging Source: Ensembl
- cardiac muscle cell action potential Source: BHF-UCL
- cardiac muscle contraction Source: MGI
- cellular protein localization Source: BHF-UCL
- cerebral cortex development Source: Ensembl
- establishment of blood-nerve barrier Source: MGI
- establishment of glial blood-brain barrier Source: MGI
- muscle cell cellular homeostasis Source: MGI
- muscle cell development Source: MGI
- muscle organ development Source: MGI
- myotube cell development Source: MGI
- negative regulation of ERK1 and ERK2 cascade Source: MGI
- negative regulation of neuron differentiation Source: MGI
- negative regulation of peptidyl-cysteine S-nitrosylation Source: BHF-UCL
- negative regulation of peptidyl-serine phosphorylation Source: BHF-UCL
- neuron development Source: GO_Central
- neuron projection morphogenesis Source: MGI
- neurotransmitter receptor metabolic process Source: MGI
- nucleus localization Source: MGI
- olfactory nerve structural organization Source: MGI
- peptide biosynthetic process Source: MGI
- positive regulation of cell-matrix adhesion Source: BHF-UCL
- positive regulation of cell population proliferation Source: MGI
- positive regulation of neuron differentiation Source: MGI
- positive regulation of neuron projection development Source: MGI
- positive regulation of sodium ion transmembrane transporter activity Source: BHF-UCL
- protein-containing complex assembly Source: BHF-UCL
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion Source: BHF-UCL
- regulation of cell cycle Source: MGI
- regulation of cellular response to growth factor stimulus Source: MGI
- regulation of gene expression Source: MGI
- regulation of heart rate Source: BHF-UCL
- regulation of membrane potential Source: MGI
- regulation of muscle system process Source: GO_Central
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Source: BHF-UCL
- regulation of ryanodine-sensitive calcium-release channel activity Source: BHF-UCL
- regulation of skeletal muscle contraction Source: BHF-UCL
- regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion Source: BHF-UCL
- regulation of transcription, DNA-templated Source: MGI
- regulation of voltage-gated calcium channel activity Source: BHF-UCL
- response to denervation involved in regulation of muscle adaptation Source: Ensembl
- response to muscle stretch Source: MGI
- response to water deprivation Source: Ensembl
- skeletal muscle tissue development Source: MGI
- skeletal muscle tissue regeneration Source: Ensembl
Keywordsi
Molecular function | Actin-binding |
Ligand | Calcium, Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-390522, Striated Muscle Contraction |
Names & Taxonomyi
Protein namesi | Recommended name: Dystrophin |
Gene namesi | Name:Dmd |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:94909, Dmd |
VEuPathDBi | HostDB:ENSMUSG00000045103 |
Subcellular locationi
Plasma membrane
- sarcolemma 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication
- postsynaptic cell membrane 1 Publication
Cytoskeleton
- cytoskeleton 1 Publication
Note: In muscle cells, sarcolemma localization requires the presence of ANK2, while localization to costameres requires the presence of ANK3. Localizes to neuromuscular junctions (NMJs). In adult muscle, NMJ localization depends upon ANK2 presence, but not in newborn animals.
Cytoskeleton
- cortical actin cytoskeleton Source: GO_Central
- neurofilament Source: MGI
Golgi apparatus
- Golgi apparatus Source: MGI
Mitochondrion
- matrix side of mitochondrial inner membrane Source: MGI
- mitochondrial outer membrane Source: MGI
Nucleus
- nucleus Source: MGI
Plasma Membrane
- dystrophin-associated glycoprotein complex Source: MGI
- filopodium membrane Source: MGI
- plasma membrane Source: MGI
- postsynaptic membrane Source: UniProtKB-SubCell
- sarcolemma Source: MGI
Other locations
- astrocyte projection Source: MGI
- axon Source: MGI
- cell junction Source: MGI
- cell projection Source: MGI
- cell surface Source: MGI
- cell-substrate junction Source: MGI
- costamere Source: MGI
- filopodium Source: MGI
- lamellipodium Source: MGI
- membrane raft Source: MGI
- myofibril Source: MGI
- neuron projection Source: MGI
- neuron projection terminus Source: MGI
- neuronal cell body Source: MGI
- perinuclear region of cytoplasm Source: MGI
- postsynaptic density Source: MGI
- protein-containing complex Source: MGI
- ribosome Source: MGI
- secretory granule Source: MGI
- synapse Source: MGI
- synaptic vesicle membrane Source: MGI
- Z disc Source: MGI
Keywords - Cellular componenti
Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Postsynaptic cell membrane, SynapsePathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076076 | 1 – 3678 | DystrophinAdd BLAST | 3678 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 3476 | PhosphoserineBy similarity | 1 | |
Modified residuei | 3483 | PhosphoserineBy similarity | 1 | |
Modified residuei | 3493 | PhosphoserineBy similarity | 1 | |
Modified residuei | 3605 | PhosphoserineBy similarity | 1 | |
Modified residuei | 3606 | PhosphoserineBy similarity | 1 | |
Modified residuei | 3610 | PhosphoserineCombined sources | 1 | |
Modified residuei | 3616 | PhosphoserineCombined sources | 1 | |
Modified residuei | 3617 | PhosphoserineCombined sources | 1 | |
Modified residuei | 3659 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | P11531 |
jPOSTi | P11531 |
MaxQBi | P11531 |
PaxDbi | P11531 |
PeptideAtlasi | P11531 |
PRIDEi | P11531 |
ProteomicsDBi | 277346 [P11531-1] |
PTM databases
iPTMneti | P11531 |
PhosphoSitePlusi | P11531 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000045103, Expressed in pineal body and 332 other tissues |
ExpressionAtlasi | P11531, baseline and differential |
Genevisiblei | P11531, MM |
Interactioni
Subunit structurei
Interacts with SYNM (PubMed:16777071).
Interacts with the syntrophins SNTG1 and SNTG2.
Interacts with KRT19.
Component of the dystrophin-associated glycoprotein complex which is composed of three subcomplexes: a cytoplasmic complex comprised of DMD (or UTRN), DTNA and a number of syntrophins, such as SNTB1, SNTB2, SNTG1 and SNTG2, the transmembrane dystroglycan complex, and the sarcoglycan-sarcospan complex.
Interacts with DAG1 (betaDAG1) with DMD; the interaction is inhibited by phosphorylation on the PPXY motif of DAG1 (By similarity).
Interacts with SYNM; SNTA1 and SNTB1.
Interacts with CMYA5 (PubMed:20634290). Directly interacts with ANK2 and ANK3; these interactions do not interfere with betaDAG1-binding and are necessary for proper localization in muscle cells (PubMed:19109891).
Identified in a dystroglycan complex that contains at least PRX, DRP2, UTRN, DMD and DAG1 (PubMed:11430802).
Interacts with DTNB (PubMed:10893187).
Interacts with PGM5; the interaction is direct (PubMed:7890770).
By similarity9 PublicationsBinary interactionsi
P11531
With | #Exp. | IntAct |
---|---|---|
Nde1 - isoform 1 [Q9CZA6-1] | 2 | EBI-295928,EBI-15949673 |
Snta1 [Q61234] | 4 | EBI-295928,EBI-295952 |
GO - Molecular functioni
- actin binding Source: MGI
- actin filament binding Source: GO_Central
- dystroglycan binding Source: MGI
- integrin binding Source: MGI
- lamin binding Source: MGI
- myosin binding Source: MGI
- nitric-oxide synthase binding Source: BHF-UCL
- PDZ domain binding Source: MGI
- vinculin binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 199245, 47 interactors |
CORUMi | P11531 |
DIPi | DIP-32899N |
IntActi | P11531, 48 interactors |
MINTi | P11531 |
STRINGi | 10090.ENSMUSP00000109633 |
Miscellaneous databases
RNActi | P11531, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 15 – 119 | Calponin-homology (CH) 1PROSITE-ProRule annotationAdd BLAST | 105 | |
Domaini | 134 – 240 | Calponin-homology (CH) 2PROSITE-ProRule annotationAdd BLAST | 107 | |
Repeati | 341 – 449 | Spectrin 1Add BLAST | 109 | |
Repeati | 450 – 558 | Spectrin 2Add BLAST | 109 | |
Repeati | 561 – 669 | Spectrin 3Add BLAST | 109 | |
Repeati | 721 – 830 | Spectrin 4Add BLAST | 110 | |
Repeati | 832 – 936 | Spectrin 5Add BLAST | 105 | |
Repeati | 945 – 1047 | Spectrin 6Add BLAST | 103 | |
Repeati | 1050 – 1156 | Spectrin 7Add BLAST | 107 | |
Repeati | 1159 – 1265 | Spectrin 8Add BLAST | 107 | |
Repeati | 1268 – 1369 | Spectrin 9Add BLAST | 102 | |
Repeati | 1370 – 1465 | Spectrin 10Add BLAST | 96 | |
Repeati | 1470 – 1570 | Spectrin 11Add BLAST | 101 | |
Repeati | 1573 – 1678 | Spectrin 12Add BLAST | 106 | |
Repeati | 1681 – 1780 | Spectrin 13Add BLAST | 100 | |
Repeati | 1781 – 1876 | Spectrin 14Add BLAST | 96 | |
Repeati | 1879 – 1981 | Spectrin 15Add BLAST | 103 | |
Repeati | 1994 – 2103 | Spectrin 16Add BLAST | 110 | |
Repeati | 2106 – 2210 | Spectrin 17Add BLAST | 105 | |
Repeati | 2213 – 2318 | Spectrin 18Add BLAST | 106 | |
Repeati | 2319 – 2416 | Spectrin 19Add BLAST | 98 | |
Repeati | 2468 – 2570 | Spectrin 20Add BLAST | 103 | |
Repeati | 2573 – 2679 | Spectrin 21Add BLAST | 107 | |
Repeati | 2682 – 2795 | Spectrin 22Add BLAST | 114 | |
Repeati | 2801 – 2923 | Spectrin 23Add BLAST | 123 | |
Repeati | 2928 – 3033 | Spectrin 24Add BLAST | 106 | |
Domaini | 3048 – 3081 | WWPROSITE-ProRule annotationAdd BLAST | 34 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 240 | Actin-bindingAdd BLAST | 240 | |
Regioni | 63 – 72 | ANK2- and ANK-3 binding | 10 | |
Regioni | 313 – 333 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 1417 – 1915 | Interaction with SYNM1 PublicationAdd BLAST | 499 | |
Regioni | 3051 – 3401 | Interaction with SYNM1 PublicationAdd BLAST | 351 | |
Regioni | 3459 – 3511 | Binds to SNTB1By similarityAdd BLAST | 53 | |
Regioni | 3521 – 3547 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 3596 – 3678 | DisorderedSequence analysisAdd BLAST | 83 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 3596 – 3665 | Polar residuesSequence analysisAdd BLAST | 70 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 3301 – 3357 | ZZ-type; degeneratePROSITE-ProRule annotationAdd BLAST | 57 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG4286, Eukaryota |
GeneTreei | ENSGT00940000154342 |
HOGENOMi | CLU_000246_1_0_1 |
InParanoidi | P11531 |
OMAi | LQHPEDN |
OrthoDBi | 72477at2759 |
PhylomeDBi | P11531 |
TreeFami | TF320178 |
Family and domain databases
CDDi | cd00014, CH, 2 hits cd00176, SPEC, 11 hits cd00201, WW, 1 hit |
Gene3Di | 1.10.418.10, 2 hits 3.30.60.90, 1 hit |
InterProi | View protein in InterPro IPR001589, Actinin_actin-bd_CS IPR001715, CH-domain IPR036872, CH_dom_sf IPR035436, Dystrophin/utrophin IPR011992, EF-hand-dom_pair IPR015153, EF-hand_dom_typ1 IPR015154, EF-hand_dom_typ2 IPR018159, Spectrin/alpha-actinin IPR002017, Spectrin_repeat IPR001202, WW_dom IPR036020, WW_dom_sf IPR000433, Znf_ZZ IPR043145, Znf_ZZ_sf |
Pfami | View protein in Pfam PF00307, CH, 2 hits PF09068, EF-hand_2, 1 hit PF09069, EF-hand_3, 1 hit PF00435, Spectrin, 16 hits PF00397, WW, 1 hit PF00569, ZZ, 1 hit |
PIRSFi | PIRSF002341, Dystrophin/utrophin, 1 hit |
SMARTi | View protein in SMART SM00033, CH, 2 hits SM00150, SPEC, 22 hits SM00456, WW, 1 hit SM00291, ZnF_ZZ, 1 hit |
SUPFAMi | SSF47473, SSF47473, 2 hits SSF47576, SSF47576, 1 hit SSF51045, SSF51045, 1 hit |
PROSITEi | View protein in PROSITE PS00019, ACTININ_1, 1 hit PS00020, ACTININ_2, 1 hit PS50021, CH, 2 hits PS01159, WW_DOMAIN_1, 1 hit PS50020, WW_DOMAIN_2, 1 hit PS01357, ZF_ZZ_1, 1 hit PS50135, ZF_ZZ_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry describes 1 produced by isoform ialternative splicing. AlignAdd to basketThis entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLWWEEVEDC YEREDVQKKT FTKWINAQFS KFGKQHIDNL FSDLQDGKRL
60 70 80 90 100
LDLLEGLTGQ KLPKEKGSTR VHALNNVNKA LRVLQKNNVD LVNIGSTDIV
110 120 130 140 150
DGNHKLTLGL IWNIILHWQV KNVMKTIMAG LQQTNSEKIL LSWVRQSTRN
160 170 180 190 200
YPQVNVINFT SSWSDGLALN ALIHSHRPDL FDWNSVVSQH SATQRLEHAF
210 220 230 240 250
NIAKCQLGIE KLLDPEDVAT TYPDKKSILM YITSLFQVLP QQVSIEAIQE
260 270 280 290 300
VEMLPRTSSK VTREEHFQLH HQMHYSQQIT VSLAQGYEQT SSSPKPRFKS
310 320 330 340 350
YAFTQAAYVA TSDSTQSPYP SQHLEAPRDK SLDSSLMETE VNLDSYQTAL
360 370 380 390 400
EEVLSWLLSA EDTLRAQGEI SNDVEEVKEQ FHAHEGFMMD LTSHQGLVGN
410 420 430 440 450
VLQLGSQLVG KGKLSEDEEA EVQEQMNLLN SRWECLRVAS MEKQSKLHKV
460 470 480 490 500
LMDLQNQKLK ELDDWLTKTE ERTKKMEEEP FGPDLEDLKC QVQQHKVLQE
510 520 530 540 550
DLEQEQVRVN SLTHMVVVVD ESSGDHATAA LEEQLKVLGD RWANICRWTE
560 570 580 590 600
DRWIVLQDIL LKWQHFTEEQ CLFSTWLSEK EDAMKNIQTS GFKDQNEMMS
610 620 630 640 650
SLHKISTLKI DLEKKKPTME KLSSLNQDLL SALKNKSVTQ KMEIWMENFA
660 670 680 690 700
QRWDNLTQKL EKSSAQISQA VTTTQPSLTQ TTVMETVTMV TTREQIMVKH
710 720 730 740 750
AQEELPPPPP QKKRQITVDS ELRKRLDVDI TELHSWITRS EAVLQSSEFA
760 770 780 790 800
VYRKEGNISD LQEKVNAIAR EKAEKFRKLQ DASRSAQALV EQMANEGVNA
810 820 830 840 850
ESIRQASEQL NSRWTEFCQL LSERVNWLEY QTNIITFYNQ LQQLEQMTTT
860 870 880 890 900
AENLLKTQST TLSEPTAIKS QLKICKDEVN RLSALQPQIE QLKIQSLQLK
910 920 930 940 950
EKGQGPMFLD ADFVAFTNHF NHIFDGVRAK EKELQTIFDT LPPMRYQETM
960 970 980 990 1000
SSIRTWIQQS ESKLSVPYLS VTEYEIMEER LGKLQALQSS LKEQQNGFNY
1010 1020 1030 1040 1050
LSDTVKEMAK KAPSEICQKY LSEFEEIEGH WKKLSSQLVE SCQKLEEHMN
1060 1070 1080 1090 1100
KLRKFQNHIK TLQKWMAEVD VFLKEEWPAL GDAEILKKQL KQCRLLVGDI
1110 1120 1130 1140 1150
QTIQPSLNSV NEGGQKIKSE AELEFASRLE TELRELNTQW DHICRQVYTR
1160 1170 1180 1190 1200
KEALKAGLDK TVSLQKDLSE MHEWMTQAEE EYLERDFEYK TPDELQTAVE
1210 1220 1230 1240 1250
EMKRAKEEAL QKETKVKLLT ETVNSVIAHA PPSAQEALKK ELETLTTNYQ
1260 1270 1280 1290 1300
WLCTRLNGKC KTLEEVWACW HELLSYLEKA NKWLNEVELK LKTMENVPAG
1310 1320 1330 1340 1350
PEEITEVLES LENLMHHSEE NPNQIRLLAQ TLTDGGVMDE LINEELETFN
1360 1370 1380 1390 1400
SRWRELHEEA VRKQKLLEQS IQSAQEIEKS LHLIQESLEF IDKQLAAYIT
1410 1420 1430 1440 1450
DKVDAAQMPQ EAQKIQSDLT SHEISLEEMK KHNQGKDANQ RVLSQIDVAQ
1460 1470 1480 1490 1500
KKLQDVSMKF RLFQKPANFE QRLEESKMIL DEVKMHLPAL ETKSVEQEVI
1510 1520 1530 1540 1550
QSQLSHCVNL YKSLSEVKSE VEMVIKTGRQ IVQKKQTENP KELDERVTAL
1560 1570 1580 1590 1600
KLHYNELGAK VTERKQQLEK CLKLSRKMRK EMNVLTEWLA ATDTELTKRS
1610 1620 1630 1640 1650
AVEGMPSNLD SEVAWGKATQ KEIEKQKAHL KSVTELGESL KMVLGKKETL
1660 1670 1680 1690 1700
VEDKLSLLNS NWIAVTSRVE EWLNLLLEYQ KHMETFDQNI EQITKWIIHA
1710 1720 1730 1740 1750
DELLDESEKK KPQQKEDILK RLKAEMNDMR PKVDSTRDQA AKLMANRGDH
1760 1770 1780 1790 1800
CRKVVEPQIS ELNRRFAAIS HRIKTGKASI PLKELEQFNS DIQKLLEPLE
1810 1820 1830 1840 1850
AEIQQGVNLK EEDFNKDMSE DNEGTVNELL QRGDNLQQRI TDERKREEIK
1860 1870 1880 1890 1900
IKQQLLQTKH NALKDLRSQR RKKALEISHQ WYQYKRQADD LLKCLDEIEK
1910 1920 1930 1940 1950
KLASLPEPRD ERKLKEIDRE LQKKKEELNA VRRQAEGLSE NGAAMAVEPT
1960 1970 1980 1990 2000
QIQLSKRWRQ IESNFAQFRR LNFAQIHTLH EETMVVTTED MPLDVSYVPS
2010 2020 2030 2040 2050
TYLTEISHIL QALSEVDHLL NTPELCAKDF EDLFKQEESL KNIKDNLQQI
2060 2070 2080 2090 2100
SGRIDIIHKK KTAALQSATS MEKVKVQEAV AQMDFQGEKL HRMYKERQGR
2110 2120 2130 2140 2150
FDRSVEKWRH FHYDMKVFNQ WLNEVEQFFK KTQNPENWEH AKYKWYLKEL
2160 2170 2180 2190 2200
QDGIGQRQAV VRTLNATGEE IIQQSSKTDV NILQEKLGSL SLRWHDICKE
2210 2220 2230 2240 2250
LAERRKRIEE QKNVLSEFQR DLNEFVLWLE EADNIAITPL GDEQQLKEQL
2260 2270 2280 2290 2300
EQVKLLAEEL PLRQGILKQL NETGGAVLVS APIRPEEQDK LEKKLKQTNL
2310 2320 2330 2340 2350
QWIKVSRALP EKQGELEVHL KDFRQLEEQL DHLLLWLSPI RNQLEIYNQP
2360 2370 2380 2390 2400
SQAGPFDIKE IEVTVHGKQA DVERLLSKGQ HLYKEKPSTQ PVKRKLEDLR
2410 2420 2430 2440 2450
SEWEAVNHLL RELRTKQPDR APGLSTTGAS ASQTVTLVTQ SVVTKETVIS
2460 2470 2480 2490 2500
KLEMPSSLLL EVPALADFNR AWTELTDWLS LLDRVIKSQR VMVGDLEDIN
2510 2520 2530 2540 2550
EMIIKQKATL QDLEQRRPQL EELITAAQNL KNKTSNQEAR TIITDRIERI
2560 2570 2580 2590 2600
QIQWDEVQEQ LQNRRQQLNE MLKDSTQWLE AKEEAEQVIG QVRGKLDSWK
2610 2620 2630 2640 2650
EGPHTVDAIQ KKITETKQLA KDLRQRQISV DVANDLALKL LRDYSADDTR
2660 2670 2680 2690 2700
KVHMITENIN TSWGNIHKRV SEQEAALEET HRLLQQFPLD LEKFLSWITE
2710 2720 2730 2740 2750
AETTANVLQD ASRKEKLLED SRGVRELMKP WQDLQGEIET HTDIYHNLDE
2760 2770 2780 2790 2800
NGQKILRSLE GSDEAPLLQR RLDNMNFKWS ELQKKSLNIR SHLEASSDQW
2810 2820 2830 2840 2850
KRLHLSLQEL LVWLQLKDDE LSRQAPIGGD FPAVQKQNDI HRAFKRELKT
2860 2870 2880 2890 2900
KEPVIMSTLE TVRIFLTEQP LEGLEKLYQE PRELPPEERA QNVTRLLRKQ
2910 2920 2930 2940 2950
AEEVNAEWDK LNLRSADWQR KIDEALERLQ ELQEAADELD LKLRQAEVIK
2960 2970 2980 2990 3000
GSWQPVGDLL IDSLQDHLEK VKALRGEIAP LKENVNRVND LAHQLTTLGI
3010 3020 3030 3040 3050
QLSPYNLSTL EDLNTRWRLL QVAVEDRVRQ LHEAHRDFGP ASQHFLSTSV
3060 3070 3080 3090 3100
QGPWERAISP NKVPYYINHE TQTTCWDHPK MTELYQSLAD LNNVRFSAYR
3110 3120 3130 3140 3150
TAMKLRRLQK ALCLDLLSLS AACDALDQHN LKQNDQPMDI LQIINCLTTI
3160 3170 3180 3190 3200
YDRLEQEHNN LVNVPLCVDM CLNWLLNVYD TGRTGRIRVL SFKTGIISLC
3210 3220 3230 3240 3250
KAHLEDKYRY LFKQVASSTG FCDQRRLGLL LHDSIQIPRQ LGEVASFGGS
3260 3270 3280 3290 3300
NIEPSVRSCF QFANNKPEIE AALFLDWMRL EPQSMVWLPV LHRVAAAETA
3310 3320 3330 3340 3350
KHQAKCNICK ECPIIGFRYR SLKHFNYDIC QSCFFSGRVA KGHKMHYPMV
3360 3370 3380 3390 3400
EYCTPTTSGE DVRDFAKVLK NKFRTKRYFA KHPRMGYLPV QTVLEGDNME
3410 3420 3430 3440 3450
TPVTLINFWP VDSAPASSPQ LSHDDTHSRI EHYASRLAEM ENSNGSYLND
3460 3470 3480 3490 3500
SISPNESIDD EHLLIQHYCQ SLNQDSPLSQ PRSPAQILIS LESEERGELE
3510 3520 3530 3540 3550
RILADLEEEN RNLQAEYDRL KQQHEHKGLS PLPSPPEMMP TSPQSPRDAE
3560 3570 3580 3590 3600
LIAEAKLLRQ HKGRLEARMQ ILEDHNKQLE SQLHRLRQLL EQPQAEAKVN
3610 3620 3630 3640 3650
GTTVSSPSTS LQRSDSSQPM LLRVVGSQTS ESMGEEDLLS PPQDTSTGLE
3660 3670
EVMEQLNNSF PSSRGRNAPG KPMREDTM
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A668KLA2 | A0A668KLA2_MOUSE | Dystrophin | Dmd | 2,332 | Annotation score: | ||
A2A9Z1 | A2A9Z1_MOUSE | Dystrophin | Dmd | 604 | Annotation score: | ||
A2A9Z2 | A2A9Z2_MOUSE | Dystrophin | Dmd | 617 | Annotation score: | ||
A0A1Q1PRS4 | A0A1Q1PRS4_MOUSE | Dystrophin | Dmd dmd | 525 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 463 | D → H in AAA37530 (PubMed:3659917).Curated | 1 | |
Sequence conflicti | 677 | S → F in AAA37530 (PubMed:3659917).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M68859 mRNA Translation: AAB02797.1 AL645477 Genomic DNA No translation available. AL645848 Genomic DNA No translation available. AL645857 Genomic DNA No translation available. AL672146 Genomic DNA No translation available. AL731776 Genomic DNA No translation available. AL732449 Genomic DNA No translation available. AL806516 Genomic DNA No translation available. AL808024 Genomic DNA No translation available. AL833800 Genomic DNA No translation available. AL844151 Genomic DNA No translation available. BX000479 Genomic DNA No translation available. BX294443 Genomic DNA No translation available. CR352330 Genomic DNA No translation available. CR382328 Genomic DNA No translation available. X58153 Genomic DNA Translation: CAA41157.1 M18025 mRNA Translation: AAA37530.1 U56724 Genomic DNA Translation: AAB01216.1 U15218 mRNA Translation: AAA87068.1 |
CCDSi | CCDS41047.1 [P11531-1] |
PIRi | S28916 |
RefSeqi | NP_031894.1, NM_007868.6 [P11531-1] |
Genome annotation databases
Ensembli | ENSMUST00000114000; ENSMUSP00000109633; ENSMUSG00000045103 [P11531-1] |
GeneIDi | 13405 |
KEGGi | mmu:13405 |
UCSCi | uc009tri.2, mouse [P11531-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M68859 mRNA Translation: AAB02797.1 AL645477 Genomic DNA No translation available. AL645848 Genomic DNA No translation available. AL645857 Genomic DNA No translation available. AL672146 Genomic DNA No translation available. AL731776 Genomic DNA No translation available. AL732449 Genomic DNA No translation available. AL806516 Genomic DNA No translation available. AL808024 Genomic DNA No translation available. AL833800 Genomic DNA No translation available. AL844151 Genomic DNA No translation available. BX000479 Genomic DNA No translation available. BX294443 Genomic DNA No translation available. CR352330 Genomic DNA No translation available. CR382328 Genomic DNA No translation available. X58153 Genomic DNA Translation: CAA41157.1 M18025 mRNA Translation: AAA37530.1 U56724 Genomic DNA Translation: AAB01216.1 U15218 mRNA Translation: AAA87068.1 |
CCDSi | CCDS41047.1 [P11531-1] |
PIRi | S28916 |
RefSeqi | NP_031894.1, NM_007868.6 [P11531-1] |
3D structure databases
SMRi | P11531 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 199245, 47 interactors |
CORUMi | P11531 |
DIPi | DIP-32899N |
IntActi | P11531, 48 interactors |
MINTi | P11531 |
STRINGi | 10090.ENSMUSP00000109633 |
PTM databases
iPTMneti | P11531 |
PhosphoSitePlusi | P11531 |
Proteomic databases
EPDi | P11531 |
jPOSTi | P11531 |
MaxQBi | P11531 |
PaxDbi | P11531 |
PeptideAtlasi | P11531 |
PRIDEi | P11531 |
ProteomicsDBi | 277346 [P11531-1] |
Protocols and materials databases
Antibodypediai | 476, 632 antibodies from 38 providers |
DNASUi | 13405 |
Genome annotation databases
Ensembli | ENSMUST00000114000; ENSMUSP00000109633; ENSMUSG00000045103 [P11531-1] |
GeneIDi | 13405 |
KEGGi | mmu:13405 |
UCSCi | uc009tri.2, mouse [P11531-1] |
Organism-specific databases
CTDi | 1756 |
MGIi | MGI:94909, Dmd |
VEuPathDBi | HostDB:ENSMUSG00000045103 |
Phylogenomic databases
eggNOGi | KOG4286, Eukaryota |
GeneTreei | ENSGT00940000154342 |
HOGENOMi | CLU_000246_1_0_1 |
InParanoidi | P11531 |
OMAi | LQHPEDN |
OrthoDBi | 72477at2759 |
PhylomeDBi | P11531 |
TreeFami | TF320178 |
Enzyme and pathway databases
Reactomei | R-MMU-390522, Striated Muscle Contraction |
Miscellaneous databases
BioGRID-ORCSi | 13405, 0 hits in 76 CRISPR screens |
ChiTaRSi | Dmd, mouse |
PROi | PR:P11531 |
RNActi | P11531, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000045103, Expressed in pineal body and 332 other tissues |
ExpressionAtlasi | P11531, baseline and differential |
Genevisiblei | P11531, MM |
Family and domain databases
CDDi | cd00014, CH, 2 hits cd00176, SPEC, 11 hits cd00201, WW, 1 hit |
Gene3Di | 1.10.418.10, 2 hits 3.30.60.90, 1 hit |
InterProi | View protein in InterPro IPR001589, Actinin_actin-bd_CS IPR001715, CH-domain IPR036872, CH_dom_sf IPR035436, Dystrophin/utrophin IPR011992, EF-hand-dom_pair IPR015153, EF-hand_dom_typ1 IPR015154, EF-hand_dom_typ2 IPR018159, Spectrin/alpha-actinin IPR002017, Spectrin_repeat IPR001202, WW_dom IPR036020, WW_dom_sf IPR000433, Znf_ZZ IPR043145, Znf_ZZ_sf |
Pfami | View protein in Pfam PF00307, CH, 2 hits PF09068, EF-hand_2, 1 hit PF09069, EF-hand_3, 1 hit PF00435, Spectrin, 16 hits PF00397, WW, 1 hit PF00569, ZZ, 1 hit |
PIRSFi | PIRSF002341, Dystrophin/utrophin, 1 hit |
SMARTi | View protein in SMART SM00033, CH, 2 hits SM00150, SPEC, 22 hits SM00456, WW, 1 hit SM00291, ZnF_ZZ, 1 hit |
SUPFAMi | SSF47473, SSF47473, 2 hits SSF47576, SSF47576, 1 hit SSF51045, SSF51045, 1 hit |
PROSITEi | View protein in PROSITE PS00019, ACTININ_1, 1 hit PS00020, ACTININ_2, 1 hit PS50021, CH, 2 hits PS01159, WW_DOMAIN_1, 1 hit PS50020, WW_DOMAIN_2, 1 hit PS01357, ZF_ZZ_1, 1 hit PS50135, ZF_ZZ_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DMD_MOUSE | |
Accessioni | P11531Primary (citable) accession number: P11531 Secondary accession number(s): A2A9Z0, O35653, Q60703 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1989 |
Last sequence update: | July 27, 2011 | |
Last modified: | May 25, 2022 | |
This is version 208 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot