UniProtKB - P11511 (CP19A_HUMAN)
Aromatase
CYP19A1
Functioni
A cytochrome P450 monooxygenase that catalyzes the conversion of C19 androgens, androst-4-ene-3,17-dione (androstenedione) and testosterone to the C18 estrogens, estrone and estradiol, respectively (PubMed:27702664, PubMed:2848247).
Catalyzes three successive oxidations of C19 androgens: two conventional oxidations at C19 yielding 19-hydroxy and 19-oxo/19-aldehyde derivatives, followed by a third oxidative aromatization step that involves C1-beta hydrogen abstraction combined with cleavage of the C10-C19 bond to yield a phenolic A ring and formic acid (PubMed:20385561).
Alternatively, the third oxidative reaction yields a 19-norsteroid and formic acid. Converts dihydrotestosterone to delta1,10-dehydro 19-nordihydrotestosterone and may play a role in homeostasis of this potent androgen (PubMed:22773874).
Also displays 2-hydroxylase activity toward estrone (PubMed:22773874).
Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:20385561, PubMed:22773874).
4 PublicationsCatalytic activityi
- 3 O2 + 3 reduced [NADPH—hemoprotein reductase] + testosterone = 17β-estradiol + formate + 4 H+ + 4 H2O + 3 oxidized [NADPH—hemoprotein reductase]1 PublicationEC:1.14.14.141 PublicationThis reaction proceeds in the forward1 Publication direction.
- androst-4-ene-3,17-dione + 3 O2 + 3 reduced [NADPH—hemoprotein reductase] = estrone + formate + 4 H+ + 4 H2O + 3 oxidized [NADPH—hemoprotein reductase]2 PublicationsEC:1.14.14.142 PublicationsThis reaction proceeds in the forward2 Publications direction.
- androst-4-ene-3,17-dione + O2 + reduced [NADPH—hemoprotein reductase] = 19-hydroxyandrost-4-ene-3,17-dione + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 19-hydroxyandrost-4-ene-3,17-dione + O2 + reduced [NADPH—hemoprotein reductase] = 19-oxo-androst-4-ene-3,17-dione + H+ + 2 H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 19-oxo-androst-4-ene-3,17-dione + O2 + reduced [NADPH—hemoprotein reductase] = estrone + formate + 2 H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- estrone + O2 + reduced [NADPH—hemoprotein reductase] = 2-hydroxyestrone + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 17β-hydroxy-5α-androstan-3-one + O2 + reduced [NADPH—hemoprotein reductase] = 17β,19-dihydroxy-3-oxo-5α-androstanone + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 17β,19-dihydroxy-3-oxo-5α-androstanone + O2 + reduced [NADPH—hemoprotein reductase] = 17β-hydroxy-3,19-dioxo-5α-androstanone + H+ + 2 H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- 17β-hydroxy-3,19-dioxo-5α-androstanone + O2 + reduced [NADPH—hemoprotein reductase] = 17β-hydroxy-3-oxo-19-nor-5α-androst-1-ene + formate + 2 H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
Cofactori
Kineticsi
- KM=0.46 µM for androst-4-ene-3,17-dione1 Publication
- KM=0.044 µM for androst-4-ene-3,17-dione (19-hydroxylation)1 Publication
- KM=21 µM for 19-hydroxyandrost-4-ene-3,17-dione1 Publication
- KM=18 µM for 19-oxo-androst-4-ene-3,17-dione1 Publication
- KM=2.7 µM for estrone (2-hydroxylation)1 Publication
- KM=3.8 µM for 17beta-hydroxy-5alpha-androstan-3-one (19-hydroxylation)1 Publication
- KM=3.2 µM for 17beta,19-dihydroxy-3-oxo-5alpha-androstanone1 Publication
- KM=7.6 µM for 17beta-hydroxy-3,19-dioxo-5alpha-androstanone1 Publication
: Steroid hormone biosynthesis Pathwayi
This protein is involved in Steroid hormone biosynthesis.2 PublicationsView all proteins of this organism that are known to be involved in Steroid hormone biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 309 | Substrate | 1 | |
Binding sitei | 374 | Substrate; via amide nitrogen | 1 | |
Metal bindingi | 437 | Iron (heme axial ligand)Combined sources1 Publication | 1 |
GO - Molecular functioni
- aromatase activity Source: UniProtKB
- electron transfer activity Source: UniProtKB
- heme binding Source: UniProtKB
- iron ion binding Source: InterPro
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Source: UniProtKB
- oxygen binding Source: ProtInc
- steroid hydroxylase activity Source: Reactome
GO - Biological processi
- androgen catabolic process Source: CAFA
- estrogen biosynthetic process Source: Reactome
- female genitalia development Source: Ensembl
- female gonad development Source: GO_Central
- mammary gland development Source: Ensembl
- negative regulation of chronic inflammatory response Source: Ensembl
- negative regulation of macrophage chemotaxis Source: Ensembl
- positive regulation of estradiol secretion Source: CAFA
- prostate gland growth Source: Ensembl
- response to estradiol Source: GO_Central
- steroid biosynthetic process Source: ProtInc
- sterol metabolic process Source: Reactome
- syncytium formation Source: ARUK-UCL
- testosterone biosynthetic process Source: Ensembl
- uterus development Source: Ensembl
Keywordsi
Molecular function | Monooxygenase, Oxidoreductase |
Biological process | Lipid metabolism |
Ligand | Heme, Iron, Metal-binding |
Enzyme and pathway databases
BRENDAi | 1.14.14.14, 2681 |
PathwayCommonsi | P11511 |
Reactomei | R-HSA-193144, Estrogen biosynthesis R-HSA-211976, Endogenous sterols R-HSA-5579030, Defective CYP19A1 causes AEXS |
SABIO-RKi | P11511 |
SignaLinki | P11511 |
SIGNORi | P11511 |
Chemistry databases
SwissLipidsi | SLP:000001716 |
Names & Taxonomyi
Protein namesi | Recommended name: Aromatase1 Publication (EC:1.14.14.142 Publications)Alternative name(s): CYPXIX Cytochrome P-450AROM Cytochrome P450 19A11 Publication Estrogen synthase |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2594, CYP19A1 |
MIMi | 107910, gene |
neXtProti | NX_P11511 |
VEuPathDBi | HostDB:ENSG00000137869 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein Curated
- Microsome membrane 1 Publication; Multi-pass membrane protein Curated
Endoplasmic reticulum
- endoplasmic reticulum Source: LIFEdb
- endoplasmic reticulum membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: ProtInc
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 19 – 39 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 303 – 323 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, MicrosomePathology & Biotechi
Involvement in diseasei
Aromatase excess syndrome (AEXS)
Aromatase deficiency (AROD)4 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_072784 | 192 | R → H in AROD; strongly reduced aromatase activity; 81% reduction of androstenedione metabolism compared to wild-type. 1 PublicationCorresponds to variant dbSNP:rs765057534Ensembl. | 1 | |
Natural variantiVAR_016962 | 365 | R → Q in AROD; 0.4% of wild-type activity. 1 PublicationCorresponds to variant dbSNP:rs80051519EnsemblClinVar. | 1 | |
Natural variantiVAR_016963 | 375 | R → C in AROD. 1 PublicationCorresponds to variant dbSNP:rs121434536EnsemblClinVar. | 1 | |
Natural variantiVAR_016964 | 435 | R → C in AROD; 1.1% of wild-type activity. 1 PublicationCorresponds to variant dbSNP:rs121434534EnsemblClinVar. | 1 | |
Natural variantiVAR_016965 | 437 | C → Y in AROD; complete loss of activity. 1 PublicationCorresponds to variant dbSNP:rs78310315EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variant, PseudohermaphroditismOrganism-specific databases
DisGeNETi | 1588 |
MalaCardsi | CYP19A1 |
MIMi | 139300, phenotype 613546, phenotype |
OpenTargetsi | ENSG00000137869 |
Orphaneti | 91, Aromatase deficiency 178345, Aromatase excess syndrome |
PharmGKBi | PA27091 |
Miscellaneous databases
Pharosi | P11511, Tclin |
Chemistry databases
ChEMBLi | CHEMBL1978 |
DrugBanki | DB02342, 2-Methoxyestradiol DB00357, Aminoglutethimide DB01217, Anastrozole DB00443, Betamethasone DB04794, Bifonazole DB06719, Buserelin DB00389, Carbimazole DB00269, Chlorotrianisene DB00856, Chlorphenesin DB04839, Cyproterone acetate DB01406, Danazol DB00255, Diethylstilbestrol DB00858, Drostanolone DB01127, Econazole DB14598, Edetate calcium disodium anhydrous DB14600, Edetate disodium anhydrous DB00974, Edetic acid DB06423, Endostatin DB00655, Estrone DB00926, Etretinate DB00990, Exemestane DB04539, Glyphosate DB01026, Ketoconazole DB01006, Letrozole DB00358, Mefloquine DB01065, Melatonin DB00333, Methadone DB06710, Methyltestosterone DB01110, Miconazole DB05749, MPI-674 DB08804, Nandrolone decanoate DB03467, Naringenin DB00184, Nicotine DB09389, Norgestrel DB01229, Paclitaxel DB05804, Prasterone sulfate DB00481, Raloxifene DB05875, Sar9, Met (O2)11-Substance P DB02901, Stanolone DB06147, Sulfathiazole DB00675, Tamoxifen DB00894, Testolactone DB00624, Testosterone DB13943, Testosterone cypionate DB13944, Testosterone enanthate DB13946, Testosterone undecanoate DB01007, Tioconazole DB00197, Troglitazone |
DrugCentrali | P11511 |
GuidetoPHARMACOLOGYi | 1362 |
Genetic variation databases
BioMutai | CYP19A1 |
DMDMi | 117293 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000051955 | 1 – 503 | AromataseAdd BLAST | 503 |
Post-translational modificationi
Proteomic databases
MassIVEi | P11511 |
PaxDbi | P11511 |
PeptideAtlasi | P11511 |
PRIDEi | P11511 |
ProteomicsDBi | 52787 [P11511-1] 71189 |
PTM databases
iPTMneti | P11511 |
PhosphoSitePlusi | P11511 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000137869, Expressed in chorionic villus and 116 other tissues |
ExpressionAtlasi | P11511, baseline and differential |
Genevisiblei | P11511, HS |
Organism-specific databases
HPAi | ENSG00000137869, Tissue enriched (placenta) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 107960, 40 interactors |
IntActi | P11511, 6 interactors |
MINTi | P11511 |
STRINGi | 9606.ENSP00000379683 |
Chemistry databases
BindingDBi | P11511 |
Miscellaneous databases
RNActi | P11511, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P11511 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P11511 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0157, Eukaryota |
GeneTreei | ENSGT00840000129915 |
HOGENOMi | CLU_041874_0_0_1 |
InParanoidi | P11511 |
OMAi | VRPFFMK |
PhylomeDBi | P11511 |
TreeFami | TF352039 |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVLEMLNPIH YNITSIVPEA MPAATMPVLL LTGLFLLVWN YEGTSSIPGP
60 70 80 90 100
GYCMGIGPLI SHGRFLWMGI GSACNYYNRV YGEFMRVWIS GEETLIISKS
110 120 130 140 150
SSMFHIMKHN HYSSRFGSKL GLQCIGMHEK GIIFNNNPEL WKTTRPFFMK
160 170 180 190 200
ALSGPGLVRM VTVCAESLKT HLDRLEEVTN ESGYVDVLTL LRRVMLDTSN
210 220 230 240 250
TLFLRIPLDE SAIVVKIQGY FDAWQALLIK PDIFFKISWL YKKYEKSVKD
260 270 280 290 300
LKDAIEVLIA EKRRRISTEE KLEECMDFAT ELILAEKRGD LTRENVNQCI
310 320 330 340 350
LEMLIAAPDT MSVSLFFMLF LIAKHPNVEE AIIKEIQTVI GERDIKIDDI
360 370 380 390 400
QKLKVMENFI YESMRYQPVV DLVMRKALED DVIDGYPVKK GTNIILNIGR
410 420 430 440 450
MHRLEFFPKP NEFTLENFAK NVPYRYFQPF GFGPRGCAGK YIAMVMMKAI
460 470 480 490 500
LVTLLRRFHV KTLQGQCVES IQKIHDLSLH PDETKNMLEM IFTPRNSDRC
LEH
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PGZ6 | E9PGZ6_HUMAN | Aromatase | CYP19A1 | 166 | Annotation score: | ||
H0YK57 | H0YK57_HUMAN | Aromatase | CYP19A1 | 138 | Annotation score: | ||
H0YKN1 | H0YKN1_HUMAN | Aromatase | CYP19A1 | 172 | Annotation score: | ||
H0YLS2 | H0YLS2_HUMAN | Aromatase | CYP19A1 | 164 | Annotation score: | ||
H0YLP1 | H0YLP1_HUMAN | Aromatase | CYP19A1 | 283 | Annotation score: | ||
H0YNJ7 | H0YNJ7_HUMAN | Aromatase | CYP19A1 | 244 | Annotation score: | ||
E7EQ08 | E7EQ08_HUMAN | Aromatase | CYP19A1 | 352 | Annotation score: | ||
E7EPL6 | E7EPL6_HUMAN | Aromatase | CYP19A1 | 242 | Annotation score: | ||
A0A087WVQ0 | A0A087WVQ0_HUMAN | Aromatase | CYP19A1 | 41 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 496 | N → S in AAA35557 (PubMed:2973313).Curated | 1 | |
Sequence conflicti | 496 | N → S in CAA31929 (PubMed:2973313).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_023428 | 39 | W → R2 PublicationsCorresponds to variant dbSNP:rs2236722EnsemblClinVar. | 1 | |
Natural variantiVAR_072784 | 192 | R → H in AROD; strongly reduced aromatase activity; 81% reduction of androstenedione metabolism compared to wild-type. 1 PublicationCorresponds to variant dbSNP:rs765057534Ensembl. | 1 | |
Natural variantiVAR_023429 | 201 | T → M2 PublicationsCorresponds to variant dbSNP:rs28757184EnsemblClinVar. | 1 | |
Natural variantiVAR_018406 | 264 | R → C 1.6 fold decrease in affinity for androstenedione substrate; slightly affects PKA-mediated reduction in catalytic activity as measured in vitro by estrone synthesis from androstenedione (49% decrease compared with 36% for the wild-type protein); no effect on PKG/PRKG1-mediated reduction in catalytic activity in vitro. 6 PublicationsCorresponds to variant dbSNP:rs700519EnsemblClinVar. | 1 | |
Natural variantiVAR_077526 | 264 | R → H 2.5 fold decrease in affinity for androstenedione substrate; slightly affects PKA-mediated reduction in catalytic activity as measured by estrone synthesis from androstenedione in vitro (28% decrease compared with 36% for the wild-type protein) and PKG/PRKG1-mediated reduction in catalytic activity in vitro (15% decrease compared with 30% for the wild-type protein). 1 PublicationCorresponds to variant dbSNP:rs2304462Ensembl. | 1 | |
Natural variantiVAR_079486 | 314 | S → P Found in deaf patients; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_016962 | 365 | R → Q in AROD; 0.4% of wild-type activity. 1 PublicationCorresponds to variant dbSNP:rs80051519EnsemblClinVar. | 1 | |
Natural variantiVAR_016963 | 375 | R → C in AROD. 1 PublicationCorresponds to variant dbSNP:rs121434536EnsemblClinVar. | 1 | |
Natural variantiVAR_054152 | 375 | R → L1 PublicationCorresponds to variant dbSNP:rs762631156Ensembl. | 1 | |
Natural variantiVAR_016964 | 435 | R → C in AROD; 1.1% of wild-type activity. 1 PublicationCorresponds to variant dbSNP:rs121434534EnsemblClinVar. | 1 | |
Natural variantiVAR_016965 | 437 | C → Y in AROD; complete loss of activity. 1 PublicationCorresponds to variant dbSNP:rs78310315EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055583 | 210 – 218 | ESAIVVKIQ → GTEIFTLTS in isoform 2. 1 Publication | 9 | |
Alternative sequenceiVSP_055584 | 219 – 503 | Missing in isoform 2. 1 PublicationAdd BLAST | 285 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000396402; ENSP00000379683; ENSG00000137869 ENST00000396404; ENSP00000379685; ENSG00000137869 ENST00000405913; ENSP00000383930; ENSG00000137869 [P11511-2] ENST00000557858; ENSP00000452627; ENSG00000137869 [P11511-2] ENST00000559878; ENSP00000453149; ENSG00000137869 |
GeneIDi | 1588 |
KEGGi | hsa:1588 |
MANE-Selecti | ENST00000396402.6; ENSP00000379683.1; NM_000103.4; NP_000094.2 |
UCSCi | uc001zyz.5, human [P11511-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Aromatase entry |
NIEHS-SNPs |
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3EQM | X-ray | 2.90 | A | 1-503 | [»] | |
3S79 | X-ray | 2.75 | A | 1-503 | [»] | |
3S7S | X-ray | 3.21 | A | 1-503 | [»] | |
4GL5 | X-ray | 3.48 | A | 1-503 | [»] | |
4GL7 | X-ray | 3.90 | A | 1-503 | [»] | |
4KQ8 | X-ray | 3.29 | A | 45-503 | [»] | |
5JKV | X-ray | 2.75 | A | 1-503 | [»] | |
5JKW | X-ray | 3.00 | A | 1-503 | [»] | |
5JL6 | X-ray | 3.00 | A | 1-503 | [»] | |
5JL7 | X-ray | 3.10 | A | 1-503 | [»] | |
5JL9 | X-ray | 3.10 | A | 1-503 | [»] | |
SMRi | P11511 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107960, 40 interactors |
IntActi | P11511, 6 interactors |
MINTi | P11511 |
STRINGi | 9606.ENSP00000379683 |
Chemistry databases
BindingDBi | P11511 |
ChEMBLi | CHEMBL1978 |
DrugBanki | DB02342, 2-Methoxyestradiol DB00357, Aminoglutethimide DB01217, Anastrozole DB00443, Betamethasone DB04794, Bifonazole DB06719, Buserelin DB00389, Carbimazole DB00269, Chlorotrianisene DB00856, Chlorphenesin DB04839, Cyproterone acetate DB01406, Danazol DB00255, Diethylstilbestrol DB00858, Drostanolone DB01127, Econazole DB14598, Edetate calcium disodium anhydrous DB14600, Edetate disodium anhydrous DB00974, Edetic acid DB06423, Endostatin DB00655, Estrone DB00926, Etretinate DB00990, Exemestane DB04539, Glyphosate DB01026, Ketoconazole DB01006, Letrozole DB00358, Mefloquine DB01065, Melatonin DB00333, Methadone DB06710, Methyltestosterone DB01110, Miconazole DB05749, MPI-674 DB08804, Nandrolone decanoate DB03467, Naringenin DB00184, Nicotine DB09389, Norgestrel DB01229, Paclitaxel DB05804, Prasterone sulfate DB00481, Raloxifene DB05875, Sar9, Met (O2)11-Substance P DB02901, Stanolone DB06147, Sulfathiazole DB00675, Tamoxifen DB00894, Testolactone DB00624, Testosterone DB13943, Testosterone cypionate DB13944, Testosterone enanthate DB13946, Testosterone undecanoate DB01007, Tioconazole DB00197, Troglitazone |
DrugCentrali | P11511 |
GuidetoPHARMACOLOGYi | 1362 |
SwissLipidsi | SLP:000001716 |
PTM databases
iPTMneti | P11511 |
PhosphoSitePlusi | P11511 |
Genetic variation databases
BioMutai | CYP19A1 |
DMDMi | 117293 |
Proteomic databases
MassIVEi | P11511 |
PaxDbi | P11511 |
PeptideAtlasi | P11511 |
PRIDEi | P11511 |
ProteomicsDBi | 52787 [P11511-1] 71189 |
Protocols and materials databases
ABCDi | P11511, 1 sequenced antibody |
Antibodypediai | 4371, 674 antibodies from 41 providers |
DNASUi | 1588 |
Genome annotation databases
Ensembli | ENST00000396402; ENSP00000379683; ENSG00000137869 ENST00000396404; ENSP00000379685; ENSG00000137869 ENST00000405913; ENSP00000383930; ENSG00000137869 [P11511-2] ENST00000557858; ENSP00000452627; ENSG00000137869 [P11511-2] ENST00000559878; ENSP00000453149; ENSG00000137869 |
GeneIDi | 1588 |
KEGGi | hsa:1588 |
MANE-Selecti | ENST00000396402.6; ENSP00000379683.1; NM_000103.4; NP_000094.2 |
UCSCi | uc001zyz.5, human [P11511-1] |
Organism-specific databases
CTDi | 1588 |
DisGeNETi | 1588 |
GeneCardsi | CYP19A1 |
HGNCi | HGNC:2594, CYP19A1 |
HPAi | ENSG00000137869, Tissue enriched (placenta) |
MalaCardsi | CYP19A1 |
MIMi | 107910, gene 139300, phenotype 613546, phenotype |
neXtProti | NX_P11511 |
OpenTargetsi | ENSG00000137869 |
Orphaneti | 91, Aromatase deficiency 178345, Aromatase excess syndrome |
PharmGKBi | PA27091 |
VEuPathDBi | HostDB:ENSG00000137869 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0157, Eukaryota |
GeneTreei | ENSGT00840000129915 |
HOGENOMi | CLU_041874_0_0_1 |
InParanoidi | P11511 |
OMAi | VRPFFMK |
PhylomeDBi | P11511 |
TreeFami | TF352039 |
Enzyme and pathway databases
BRENDAi | 1.14.14.14, 2681 |
PathwayCommonsi | P11511 |
Reactomei | R-HSA-193144, Estrogen biosynthesis R-HSA-211976, Endogenous sterols R-HSA-5579030, Defective CYP19A1 causes AEXS |
SABIO-RKi | P11511 |
SignaLinki | P11511 |
SIGNORi | P11511 |
Miscellaneous databases
BioGRID-ORCSi | 1588, 4 hits in 1038 CRISPR screens |
ChiTaRSi | CYP19A1, human |
EvolutionaryTracei | P11511 |
GeneWikii | Aromatase |
GenomeRNAii | 1588 |
Pharosi | P11511, Tclin |
PROi | PR:P11511 |
RNActi | P11511, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000137869, Expressed in chorionic villus and 116 other tissues |
ExpressionAtlasi | P11511, baseline and differential |
Genevisiblei | P11511, HS |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CP19A_HUMAN | |
Accessioni | P11511Primary (citable) accession number: P11511 Secondary accession number(s): Q16731 Q8IYJ7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1989 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 23, 2022 | |
This is version 224 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families