CYP19A1

Functionⁱ

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Catalytic activityⁱ

Testosterone + 3 [reduced NADPH--hemoprotein reductase] + 3 O₂ = 17-beta-estradiol + formate + 4 H₂O + 3 [oxidized NADPH--hemoprotein reductase].1 Publication

Androst-4-ene-3,17-dione + 3 [reduced NADPH--hemoprotein reductase] + 3 O₂ = estrone + formate + 4 H₂O + 3 [oxidized NADPH--hemoprotein reductase].1 Publication

Cofactorⁱ

heme

Kineticsⁱ

K_M=
0.46 µM for androstenedione
1 Publication
Manual assertion based on experiment inⁱ
- Ref.26
  "Impact of R264C and R264H polymorphisms in human aromatase function."
  Baravalle R., Di Nardo G., Bandino A., Barone I., Catalano S., Ando S., Gilardi G.
  J. Steroid Biochem. Mol. Biol. 167:23-32(2017) [PubMed] [Europe PMC] [Abstract]
  Cited for: CHARACTERIZATION OF VARIANTS CYS-264 AND HIS-264, PHOSPHORYLATION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES.

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	309	Substrate	1
Binding siteⁱ	374	Substrate; via amide nitrogen	1
Metal bindingⁱ	437	Iron (heme axial ligand)	1

GO - Molecular functionⁱ

aromatase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 19129847
electron transfer activity
Source: UniProtKB
Traceable author statementⁱ
- 2848247
heme binding
Source: UniProtKB
Inferred from direct assayⁱ
- 19129847
iron ion binding Source: InterPro
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Source: UniProtKB
Traceable author statementⁱ
- 1371509
oxygen binding
Source: ProtInc
Traceable author statementⁱ
- 2848247
steroid hydroxylase activity Source: Reactome

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

androgen catabolic process
Source: CAFA
Inferred from direct assayⁱ
- 26482249
estrogen biosynthetic process Source: Reactome
female genitalia development Source: Ensembl
female gonad development Source: Ensembl
mammary gland development Source: Ensembl
negative regulation of chronic inflammatory response Source: Ensembl
negative regulation of macrophage chemotaxis Source: Ensembl
positive regulation of estradiol secretion
Source: CAFA
Inferred from direct assayⁱ
- 26482249
prostate gland growth Source: Ensembl
steroid biosynthetic process
Source: ProtInc
Traceable author statementⁱ
- 2848247
sterol metabolic process Source: Reactome
testosterone biosynthetic process Source: Ensembl
uterus development Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Monooxygenase, Oxidoreductase
Ligand	Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS06413-MONOMER
BRENDAⁱ	1.14.14.14 2681
Reactomeⁱ	R-HSA-193144 Estrogen biosynthesis R-HSA-211976 Endogenous sterols R-HSA-5579030 Defective CYP19A1 causes Aromatase excess syndrome (AEXS)
SABIO-RKⁱ	P11511
SIGNORⁱ	P11511

Chemistry databases

SwissLipidsⁱ	SLP:000001716

SwissLipidsⁱ

SLP:000001716

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Aromatase (EC:1.14.14.141 Publication) Alternative name(s): CYPXIX Cytochrome P-450AROM Cytochrome P450 19A1 Estrogen synthase
Gene namesⁱ	Name:CYP19A1 Synonyms:ARO1, CYAR, CYP19
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 15

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000137869.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2594 CYP19A1
MIMⁱ	107910 gene
neXtProtⁱ	NX_P11511

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Aromatase excess syndrome (AEXS)

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal dominant disorder characterized by increased extraglandular aromatization of steroids that presents with heterosexual precocity in males and isosexual precocity in females.

Aromatase deficiency (AROD)4 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA rare disease in which fetal androgens are not converted into estrogens due to placental aromatase deficiency. Thus, pregnant women exhibit a hirsutism, which spontaneously resolves after post-partum. At birth, female babies present with pseudohermaphroditism due to virilization of extern genital organs. In adult females, manifestations include delay of puberty, breast hypoplasia and primary amenorrhoea with multicystic ovaries.

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_072784	192	R → H in AROD; strongly reduced aromatase activity; 81% reduction of androstenedione metabolism compared to wild-type. 1 PublicationCorresponds to variant dbSNP:rs765057534Ensembl.	1
Natural variantⁱVAR_016962	365	R → Q in AROD; 0.4% of wild-type activity. 1 PublicationCorresponds to variant dbSNP:rs80051519EnsemblClinVar.	1
Natural variantⁱVAR_016963	375	R → C in AROD. 1 PublicationCorresponds to variant dbSNP:rs121434536EnsemblClinVar.	1
Natural variantⁱVAR_016964	435	R → C in AROD; 1.1% of wild-type activity. 1 PublicationCorresponds to variant dbSNP:rs121434534EnsemblClinVar.	1
Natural variantⁱVAR_016965	437	C → Y in AROD; complete loss of activity. 1 PublicationCorresponds to variant dbSNP:rs78310315EnsemblClinVar.	1

Keywords - Diseaseⁱ

Disease mutation, Pseudohermaphroditism

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1588
MalaCards human disease database More...MalaCardsⁱ	CYP19A1
MIMⁱ	139300 phenotype 613546 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000137869
Orphanetⁱ	91 Aromatase deficiency 178345 Aromatase excess syndrome
PharmGKBⁱ	PA27091

Chemistry databases

ChEMBLⁱ	CHEMBL1978
Drug and drug target database More...DrugBankⁱ	DB02342 2-Methoxyestradiol DB00357 Aminoglutethimide DB01217 Anastrozole DB05338 atamestane-plus-toremifene DB00443 Betamethasone DB04794 Bifonazole DB06719 Buserelin DB00389 Carbimazole DB00269 Chlorotrianisene DB00856 Chlorphenesin DB00882 Clomifene DB00257 Clotrimazole DB04839 Cyproterone acetate DB01406 Danazol DB05804 dehydroepiandrosterone sulfate DB01234 Dexamethasone DB00255 Diethylstilbestrol DB02901 Dihydrotestosterone DB00917 Dinoprostone DB00858 Drostanolone DB01127 Econazole DB00974 Edetic Acid DB00292 Etomidate DB00926 Etretinate DB00990 Exemestane DB01026 Ketoconazole DB01006 Letrozole DB01227 Levomethadyl Acetate DB00367 Levonorgestrel DB00358 Mefloquine DB01065 Melatonin DB00333 Methadone DB06710 Methyltestosterone DB01110 Miconazole DB05749 MPI-674 DB08804 Nandrolone decanoate DB00984 Nandrolone phenpropionate DB00184 Nicotine DB09389 Norgestrel DB01229 Paclitaxel DB00481 Raloxifene DB05875 substance P DB06147 Sulfathiazole DB00675 Tamoxifen DB00857 Terbinafine DB00894 Testolactone DB00624 Testosterone DB01007 Tioconazole DB00072 Trastuzumab DB00197 Troglitazone
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	1362

Polymorphism and mutation databases

BioMutaⁱ	CYP19A1
DMDMⁱ	117293

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000051955	1 – 503	AromataseAdd BLAST		503

Post-translational modificationⁱ

Phosphorylated in vitro by PKA and PKG/PRKG1. These phosphorylations inhibit the catalytic activity as measured by estrone synthesis from androstenedione (36% decrease for PKA and 30% for PKG/PRKG1).1 Publication

Proteomic databases

PaxDbⁱ	P11511
PeptideAtlas More...PeptideAtlasⁱ	P11511
PRIDEⁱ	P11511
ProteomicsDBⁱ	52787

PTM databases

iPTMnetⁱ	P11511
PhosphoSitePlusⁱ	P11511

Expressionⁱ

Tissue specificityⁱ

Widely expressed, including in adult and fetal brain, placenta, skin fibroblasts, adipose tissue and gonads.4 Publications

Gene expression databases

Bgeeⁱ	ENSG00000137869 Expressed in 91 organ(s), highest expression level in chorionic villus
CleanExⁱ	HS_CYP19A1
ExpressionAtlasⁱ	P11511 baseline and differential
Genevisibleⁱ	P11511 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB000355 HPA051194

HPAⁱ

CAB000355
HPA051194

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	107960, 7 interactors
IntActⁱ	P11511, 1 interactor
Molecular INTeraction database More...MINTⁱ	P11511
STRINGⁱ	9606.ENSP00000260433

Chemistry databases

BindingDBⁱ

P11511

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	54 – 56	Combined sources	3
Helixⁱ	57 – 68	Combined sources	12
Helixⁱ	70 – 80	Combined sources	11
Beta strandⁱ	83 – 97	Combined sources	15
Helixⁱ	100 – 108	Combined sources	9
Helixⁱ	110 – 112	Combined sources	3
Helixⁱ	119 – 125	Combined sources	7
Beta strandⁱ	130 – 132	Combined sources	3
Helixⁱ	138 – 151	Combined sources	14
Helixⁱ	155 – 172	Combined sources	18
Helixⁱ	173 – 177	Combined sources	5
Beta strandⁱ	183 – 185	Combined sources	3
Helixⁱ	187 – 203	Combined sources	17
Helixⁱ	210 – 227	Combined sources	18
Helixⁱ	232 – 236	Combined sources	5
Helixⁱ	238 – 240	Combined sources	3
Helixⁱ	242 – 267	Combined sources	26
Turnⁱ	270 – 275	Combined sources	6
Helixⁱ	278 – 287	Combined sources	10
Turnⁱ	288 – 290	Combined sources	3
Helixⁱ	293 – 324	Combined sources	32
Helixⁱ	326 – 339	Combined sources	14
Turnⁱ	340 – 342	Combined sources	3
Helixⁱ	347 – 349	Combined sources	3
Turnⁱ	350 – 352	Combined sources	3
Helixⁱ	354 – 366	Combined sources	13
Beta strandⁱ	373 – 376	Combined sources	4
Beta strandⁱ	381 – 383	Combined sources	3
Beta strandⁱ	386 – 388	Combined sources	3
Beta strandⁱ	393 – 396	Combined sources	4
Helixⁱ	398 – 401	Combined sources	4
Turnⁱ	402 – 404	Combined sources	3
Helixⁱ	415 – 418	Combined sources	4
Turnⁱ	424 – 426	Combined sources	3
Helixⁱ	433 – 435	Combined sources	3
Helixⁱ	440 – 455	Combined sources	16
Beta strandⁱ	458 – 463	Combined sources	6
Turnⁱ	468 – 470	Combined sources	3
Beta strandⁱ	473 – 481	Combined sources	9
Beta strandⁱ	483 – 485	Combined sources	3
Beta strandⁱ	490 – 494	Combined sources	5

Show more details

3D structure databases

ProteinModelPortalⁱ	P11511
SMRⁱ	P11511
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P11511

EvolutionaryTraceⁱ

P11511

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0157 Eukaryota COG2124 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00840000129915
HOGENOMⁱ	HOG000111912
HOVERGENⁱ	HBG050750
InParanoidⁱ	P11511
KEGG Orthology (KO) More...KOⁱ	K07434
OMAⁱ	MRRIMLD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G056R
PhylomeDBⁱ	P11511
TreeFamⁱ	TF352039

Family and domain databases

Gene3Dⁱ	1.10.630.10, 1 hit
InterProⁱ	View protein in InterPro IPR001128 Cyt_P450 IPR017972 Cyt_P450_CS IPR002401 Cyt_P450_E_grp-I IPR036396 Cyt_P450_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00067 p450, 1 hit
PRINTSⁱ	PR00463 EP450I PR00385 P450
SUPFAMⁱ	SSF48264 SSF48264, 1 hit
PROSITEⁱ	View protein in PROSITE PS00086 CYTOCHROME_P450, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P11511-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVLEMLNPIH YNITSIVPEA MPAATMPVLL LTGLFLLVWN YEGTSSIPGP 
        60         70         80         90        100
GYCMGIGPLI SHGRFLWMGI GSACNYYNRV YGEFMRVWIS GEETLIISKS 
       110        120        130        140        150
SSMFHIMKHN HYSSRFGSKL GLQCIGMHEK GIIFNNNPEL WKTTRPFFMK 
       160        170        180        190        200
ALSGPGLVRM VTVCAESLKT HLDRLEEVTN ESGYVDVLTL LRRVMLDTSN 
       210        220        230        240        250
TLFLRIPLDE SAIVVKIQGY FDAWQALLIK PDIFFKISWL YKKYEKSVKD 
       260        270        280        290        300
LKDAIEVLIA EKRRRISTEE KLEECMDFAT ELILAEKRGD LTRENVNQCI 
       310        320        330        340        350
LEMLIAAPDT MSVSLFFMLF LIAKHPNVEE AIIKEIQTVI GERDIKIDDI 
       360        370        380        390        400
QKLKVMENFI YESMRYQPVV DLVMRKALED DVIDGYPVKK GTNIILNIGR 
       410        420        430        440        450
MHRLEFFPKP NEFTLENFAK NVPYRYFQPF GFGPRGCAGK YIAMVMMKAI 
       460        470        480        490        500
LVTLLRRFHV KTLQGQCVES IQKIHDLSLH PDETKNMLEM IFTPRNSDRC 

LEH

Length:503

Mass (Da):57,883

Last modified:January 23, 2007 - v3

Checksum:ⁱ9BD9B28651D9A69A

GO

Isoform 2 (identifier: P11511-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
210-218: ESAIVVKIQ → GTEIFTLTS
219-503: Missing.

« Hide

        10         20         30         40         50
MVLEMLNPIH YNITSIVPEA MPAATMPVLL LTGLFLLVWN YEGTSSIPGP 
        60         70         80         90        100
GYCMGIGPLI SHGRFLWMGI GSACNYYNRV YGEFMRVWIS GEETLIISKS 
       110        120        130        140        150
SSMFHIMKHN HYSSRFGSKL GLQCIGMHEK GIIFNNNPEL WKTTRPFFMK 
       160        170        180        190        200
ALSGPGLVRM VTVCAESLKT HLDRLEEVTN ESGYVDVLTL LRRVMLDTSN 
       210 
TLFLRIPLDG TEIFTLTS

Note: No experimental confirmation available.

Show »

Length:218

Mass (Da):24,518

Checksum:ⁱ9C15EFD1B411087C

GO

Computationally mapped potential isoform sequencesⁱ

There are 9 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0YK57	H0YK57_HUMAN	Aromatase Aromatase	CYP19A1	138	Annotation score:
E9PGZ6	E9PGZ6_HUMAN	Aromatase Aromatase	CYP19A1	166	Annotation score:
H0YKN1	H0YKN1_HUMAN	Aromatase Aromatase	CYP19A1	172	Annotation score:
H0YLS2	H0YLS2_HUMAN	Aromatase Aromatase	CYP19A1	164	Annotation score:
E7EQ08	E7EQ08_HUMAN	Aromatase Aromatase	CYP19A1	352	Annotation score:
H0YNJ7	H0YNJ7_HUMAN	Aromatase Aromatase	CYP19A1	244	Annotation score:
H0YLP1	H0YLP1_HUMAN	Aromatase Aromatase	CYP19A1	283	Annotation score:
E7EPL6	E7EPL6_HUMAN	Aromatase Aromatase	CYP19A1	242	Annotation score:
A0A087WVQ0	A0A087WVQ0_HUMAN	Aromatase Aromatase	CYP19A1	41	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	496	N → S in AAA35557 (PubMed:2973313).Curated		1
Sequence conflictⁱ	496	N → S in CAA31929 (PubMed:2973313).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_023428	39	W → R2 PublicationsCorresponds to variant dbSNP:rs2236722EnsemblClinVar.	1
Natural variantⁱVAR_072784	192	R → H in AROD; strongly reduced aromatase activity; 81% reduction of androstenedione metabolism compared to wild-type. 1 PublicationCorresponds to variant dbSNP:rs765057534Ensembl.	1
Natural variantⁱVAR_023429	201	T → M2 PublicationsCorresponds to variant dbSNP:rs28757184EnsemblClinVar.	1
Natural variantⁱVAR_018406	264	R → C 1.6 fold decrease in affinity for androstenedione substrate; slightly affects PKA-mediated reduction in catalytic activity as measured in vitro by estrone synthesis from androstenedione (49% decrease compared with 36% for the wild-type protein); no effect on PKG/PRKG1-mediated reduction in catalytic activity in vitro. 6 PublicationsCorresponds to variant dbSNP:rs700519EnsemblClinVar.	1
Natural variantⁱVAR_077526	264	R → H 2.5 fold decrease in affinity for androstenedione substrate; slightly affects PKA-mediated reduction in catalytic activity as measured by estrone synthesis from androstenedione in vitro (28% decrease compared with 36% for the wild-type protein) and PKG/PRKG1-mediated reduction in catalytic activity in vitro (15% decrease compared with 30% for the wild-type protein). 1 PublicationCorresponds to variant dbSNP:rs2304462Ensembl.	1
Natural variantⁱVAR_079486	314	S → P Found in deaf patients; unknown pathological significance. 1 Publication	1
Natural variantⁱVAR_016962	365	R → Q in AROD; 0.4% of wild-type activity. 1 PublicationCorresponds to variant dbSNP:rs80051519EnsemblClinVar.	1
Natural variantⁱVAR_016963	375	R → C in AROD. 1 PublicationCorresponds to variant dbSNP:rs121434536EnsemblClinVar.	1
Natural variantⁱVAR_054152	375	R → L1 Publication	1
Natural variantⁱVAR_016964	435	R → C in AROD; 1.1% of wild-type activity. 1 PublicationCorresponds to variant dbSNP:rs121434534EnsemblClinVar.	1
Natural variantⁱVAR_016965	437	C → Y in AROD; complete loss of activity. 1 PublicationCorresponds to variant dbSNP:rs78310315EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_055583	210 – 218	ESAIVVKIQ → GTEIFTLTS in isoform 2. 1 Publication		9
Alternative sequenceⁱVSP_055584	219 – 503	Missing in isoform 2. 1 PublicationAdd BLAST		285

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M22246 mRNA Translation: AAA35557.1 X13589 mRNA Translation: CAA31929.1 M18856 mRNA Translation: AAA35556.1 J04127 mRNA Translation: AAA52132.1 Y07508 mRNA Translation: CAA68807.1 M30804 M30803 Genomic DNA Translation: AAA35728.1 AY957953 Genomic DNA Translation: AAX44046.1 AC012169 Genomic DNA No translation available. AC020891 Genomic DNA No translation available. BC035714 mRNA Translation: AAH35714.1 BC107785 mRNA Translation: AAI07786.1 M28420 mRNA Translation: AAA52141.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10139.1 [P11511-1]
PIRⁱ	A34451 O4HU19
NCBI Reference Sequences More...RefSeqⁱ	NP_000094.2, NM_000103.3 [P11511-1] NP_001334177.1, NM_001347248.1 [P11511-1] NP_001334178.1, NM_001347249.1 [P11511-1] NP_001334179.1, NM_001347250.1 [P11511-1] NP_001334180.1, NM_001347251.1 [P11511-1] NP_001334181.1, NM_001347252.1 [P11511-1] NP_001334182.1, NM_001347253.1 [P11511-1] NP_001334183.1, NM_001347254.1 [P11511-1] NP_001334184.1, NM_001347255.1 [P11511-1] NP_001334185.1, NM_001347256.1 [P11511-1] NP_112503.1, NM_031226.2 [P11511-1]
UniGeneⁱ	Hs.260074 Hs.641200

Genome annotation databases

Ensemblⁱ	ENST00000396402; ENSP00000379683; ENSG00000137869 [P11511-1] ENST00000396404; ENSP00000379685; ENSG00000137869 [P11511-1] ENST00000405913; ENSP00000383930; ENSG00000137869 [P11511-2] ENST00000557858; ENSP00000452627; ENSG00000137869 [P11511-2] ENST00000559878; ENSP00000453149; ENSG00000137869 [P11511-1]
GeneIDⁱ	1588
KEGGⁱ	hsa:1588
UCSC genome browser More...UCSCⁱ	uc001zyz.5 human [P11511-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P11511	Cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a		HUMAN		503	UniRef100_P11511
Uncharacterized protein		PANPA		503
CYP19A1 isoform 2 (Fragment)		PANTR		242
Aromatase (Fragment)		MACFA		83
Aromatase (Fragment)		HUMAN		242
+9
P11511-2	CYP19A1 isoform 11		PANTR		218	UniRef100_A0A2J8NSX6

Protein	Similar proteins		Species	Score	Length	Source
P11511	Aromatase		CALJA		503	UniRef90_P11511
Cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a		HUMAN		503
Uncharacterized protein		PANPA		503
CYP19A1 isoform 2 (Fragment)		PANTR		242
Aromatase (Fragment)		MACFA		83
+65
P11511-2	CYP19A1 protein		HUMAN		181	UniRef90_Q8TCA4
CYP19A1 isoform 11		PANTR		218
CYP19A1 isoform 13		PONAB		218

Protein	Similar proteins		Species	Score	Length	Source
P11511	Aromatase		RAT		508	UniRef50_P22443
Aromatase		MOUSE		503
Aromatase 3		PIG		501
Aromatase		CALJA		503
Brain aromatase		CARAU		510
+533
P11511-2	Uncharacterized protein		MACMU		244	UniRef50_A0A1D5QZ23
Aromatase (Fragment)		HUMAN		244
CYP19A1 isoform 9 (Fragment)		PONAB		244
CYP19A1 isoform 8 (Fragment)		PANTR		244
Aromatase cytochrome P450		BOVIN		218
+6

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

Aromatase entry

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M22246 mRNA Translation: AAA35557.1 X13589 mRNA Translation: CAA31929.1 M18856 mRNA Translation: AAA35556.1 J04127 mRNA Translation: AAA52132.1 Y07508 mRNA Translation: CAA68807.1 M30804 M30803 Genomic DNA Translation: AAA35728.1 AY957953 Genomic DNA Translation: AAX44046.1 AC012169 Genomic DNA No translation available. AC020891 Genomic DNA No translation available. BC035714 mRNA Translation: AAH35714.1 BC107785 mRNA Translation: AAI07786.1 M28420 mRNA Translation: AAA52141.1
CCDSⁱ	CCDS10139.1 [P11511-1]
PIRⁱ	A34451 O4HU19
RefSeqⁱ	NP_000094.2, NM_000103.3 [P11511-1] NP_001334177.1, NM_001347248.1 [P11511-1] NP_001334178.1, NM_001347249.1 [P11511-1] NP_001334179.1, NM_001347250.1 [P11511-1] NP_001334180.1, NM_001347251.1 [P11511-1] NP_001334181.1, NM_001347252.1 [P11511-1] NP_001334182.1, NM_001347253.1 [P11511-1] NP_001334183.1, NM_001347254.1 [P11511-1] NP_001334184.1, NM_001347255.1 [P11511-1] NP_001334185.1, NM_001347256.1 [P11511-1] NP_112503.1, NM_031226.2 [P11511-1]
UniGeneⁱ	Hs.260074 Hs.641200

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1TQA	model	-	A	53-495	[»]
	3EQM	X-ray	2.90	A	1-503	[»]
	3S79	X-ray	2.75	A	1-503	[»]
	3S7S	X-ray	3.21	A	1-503	[»]
	4GL5	X-ray	3.48	A	1-503	[»]
	4GL7	X-ray	3.90	A	1-503	[»]
	4KQ8	X-ray	3.29	A	45-503	[»]
	5JKV	X-ray	2.75	A	1-503	[»]
	5JKW	X-ray	3.00	A	1-503	[»]
	5JL6	X-ray	3.00	A	1-503	[»]
	5JL7	X-ray	3.10	A	1-503	[»]
	5JL9	X-ray	3.10	A	1-503	[»]
ProteinModelPortalⁱ	P11511
SMRⁱ	P11511
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107960, 7 interactors
IntActⁱ	P11511, 1 interactor
MINTⁱ	P11511
STRINGⁱ	9606.ENSP00000260433

Chemistry databases

BindingDBⁱ	P11511
ChEMBLⁱ	CHEMBL1978
DrugBankⁱ	DB02342 2-Methoxyestradiol DB00357 Aminoglutethimide DB01217 Anastrozole DB05338 atamestane-plus-toremifene DB00443 Betamethasone DB04794 Bifonazole DB06719 Buserelin DB00389 Carbimazole DB00269 Chlorotrianisene DB00856 Chlorphenesin DB00882 Clomifene DB00257 Clotrimazole DB04839 Cyproterone acetate DB01406 Danazol DB05804 dehydroepiandrosterone sulfate DB01234 Dexamethasone DB00255 Diethylstilbestrol DB02901 Dihydrotestosterone DB00917 Dinoprostone DB00858 Drostanolone DB01127 Econazole DB00974 Edetic Acid DB00292 Etomidate DB00926 Etretinate DB00990 Exemestane DB01026 Ketoconazole DB01006 Letrozole DB01227 Levomethadyl Acetate DB00367 Levonorgestrel DB00358 Mefloquine DB01065 Melatonin DB00333 Methadone DB06710 Methyltestosterone DB01110 Miconazole DB05749 MPI-674 DB08804 Nandrolone decanoate DB00984 Nandrolone phenpropionate DB00184 Nicotine DB09389 Norgestrel DB01229 Paclitaxel DB00481 Raloxifene DB05875 substance P DB06147 Sulfathiazole DB00675 Tamoxifen DB00857 Terbinafine DB00894 Testolactone DB00624 Testosterone DB01007 Tioconazole DB00072 Trastuzumab DB00197 Troglitazone
GuidetoPHARMACOLOGYⁱ	1362
SwissLipidsⁱ	SLP:000001716

PTM databases

iPTMnetⁱ	P11511
PhosphoSitePlusⁱ	P11511

Polymorphism and mutation databases

BioMutaⁱ	CYP19A1
DMDMⁱ	117293

Proteomic databases

PaxDbⁱ	P11511
PeptideAtlasⁱ	P11511
PRIDEⁱ	P11511
ProteomicsDBⁱ	52787

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1588
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000396402; ENSP00000379683; ENSG00000137869 [P11511-1] ENST00000396404; ENSP00000379685; ENSG00000137869 [P11511-1] ENST00000405913; ENSP00000383930; ENSG00000137869 [P11511-2] ENST00000557858; ENSP00000452627; ENSG00000137869 [P11511-2] ENST00000559878; ENSP00000453149; ENSG00000137869 [P11511-1]
GeneIDⁱ	1588
KEGGⁱ	hsa:1588
UCSCⁱ	uc001zyz.5 human [P11511-1]

Organism-specific databases

CTDⁱ	1588
DisGeNETⁱ	1588
EuPathDBⁱ	HostDB:ENSG00000137869.13
GeneCardsⁱ	CYP19A1
HGNCⁱ	HGNC:2594 CYP19A1
HPAⁱ	CAB000355 HPA051194
MalaCardsⁱ	CYP19A1
MIMⁱ	107910 gene 139300 phenotype 613546 phenotype
neXtProtⁱ	NX_P11511
OpenTargetsⁱ	ENSG00000137869
Orphanetⁱ	91 Aromatase deficiency 178345 Aromatase excess syndrome
PharmGKBⁱ	PA27091
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0157 Eukaryota COG2124 LUCA
GeneTreeⁱ	ENSGT00840000129915
HOGENOMⁱ	HOG000111912
HOVERGENⁱ	HBG050750
InParanoidⁱ	P11511
KOⁱ	K07434
OMAⁱ	MRRIMLD
OrthoDBⁱ	EOG091G056R
PhylomeDBⁱ	P11511
TreeFamⁱ	TF352039

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS06413-MONOMER
BRENDAⁱ	1.14.14.14 2681
Reactomeⁱ	R-HSA-193144 Estrogen biosynthesis R-HSA-211976 Endogenous sterols R-HSA-5579030 Defective CYP19A1 causes Aromatase excess syndrome (AEXS)
SABIO-RKⁱ	P11511
SIGNORⁱ	P11511

Miscellaneous databases

ChiTaRSⁱ	CYP19A1 human
EvolutionaryTraceⁱ	P11511
GeneWikiⁱ	Aromatase
GenomeRNAiⁱ	1588
Protein Ontology More...PROⁱ	PR:P11511
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000137869 Expressed in 91 organ(s), highest expression level in chorionic villus
CleanExⁱ	HS_CYP19A1
ExpressionAtlasⁱ	P11511 baseline and differential
Genevisibleⁱ	P11511 HS

Family and domain databases

Gene3Dⁱ	1.10.630.10, 1 hit
InterProⁱ	View protein in InterPro IPR001128 Cyt_P450 IPR017972 Cyt_P450_CS IPR002401 Cyt_P450_E_grp-I IPR036396 Cyt_P450_sf
Pfamⁱ	View protein in Pfam PF00067 p450, 1 hit
PRINTSⁱ	PR00463 EP450I PR00385 P450
SUPFAMⁱ	SSF48264 SSF48264, 1 hit
PROSITEⁱ	View protein in PROSITE PS00086 CYTOCHROME_P450, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CP19A_HUMAN
Accessionⁱ	P11511Primary (citable) accession number: P11511 Secondary accession number(s): Q16731 , Q3B764, Q58FA0, Q8IYJ7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
	Last sequence update:	January 23, 2007
	Last modified:	September 12, 2018
	This is version 203 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM

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UniProtKB - P11511 (CP19A_HUMAN)

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Aromatase

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Aromatase excess syndrome (AEXS)

Keywords - Diseasei

Organism-specific databases

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<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

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<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

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<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

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<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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Keywords - Coding sequence diversityi

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Functionⁱ

Kineticsⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ