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Entry version 223 (29 Sep 2021)
Sequence version 3 (23 Jan 2007)
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Protein

Aromatase

Gene

CYP19A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

A cytochrome P450 monooxygenase that catalyzes the conversion of C19 androgens, androst-4-ene-3,17-dione (androstenedione) and testosterone to the C18 estrogens, estrone and estradiol, respectively (PubMed:27702664, PubMed:2848247).

Catalyzes three successive oxidations of C19 androgens: two conventional oxidations at C19 yielding 19-hydroxy and 19-oxo/19-aldehyde derivatives, followed by a third oxidative aromatization step that involves C1-beta hydrogen abstraction combined with cleavage of the C10-C19 bond to yield a phenolic A ring and formic acid (PubMed:20385561).

Alternatively, the third oxidative reaction yields a 19-norsteroid and formic acid. Converts dihydrotestosterone to delta1,10-dehydro 19-nordihydrotestosterone and may play a role in homeostasis of this potent androgen (PubMed:22773874).

Also displays 2-hydroxylase activity toward estrone (PubMed:22773874).

Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:20385561, PubMed:22773874).

4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

heme1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 0.060 sec(-1) with androst-4-ene-3,17-dione as substrate (PubMed:20385561). kcat is 0.13 sec(-1) with 19-oxo-androst-4-ene-3,17-dione (PubMed:20385561). kcat is 0.42 sec(-1) with androst-4-ene-3,17-dione as substrate (PubMed:20385561). kcat is 0.046 min(-1) with estrone as substrate (PubMed:22773874). kcat is 0.27 min(-1) with 17beta-hydroxy-5alpha-androstan-3-one as substrate (PubMed:22773874). kcat is 0.32 min(-1) with 17beta,19-dihydroxy-3-oxo-5alpha-androstanone as substrate (PubMed:22773874). kcat is 0.77 min(-1) with 17beta-hydroxy-3,19-dioxo-5alpha-androstanone as substrate (PubMed:22773874).2 Publications
  1. KM=0.46 µM for androst-4-ene-3,17-dione1 Publication
  2. KM=0.044 µM for androst-4-ene-3,17-dione (19-hydroxylation)1 Publication
  3. KM=21 µM for 19-hydroxyandrost-4-ene-3,17-dione1 Publication
  4. KM=18 µM for 19-oxo-androst-4-ene-3,17-dione1 Publication
  5. KM=2.7 µM for estrone (2-hydroxylation)1 Publication
  6. KM=3.8 µM for 17beta-hydroxy-5alpha-androstan-3-one (19-hydroxylation)1 Publication
  7. KM=3.2 µM for 17beta,19-dihydroxy-3-oxo-5alpha-androstanone1 Publication
  8. KM=7.6 µM for 17beta-hydroxy-3,19-dioxo-5alpha-androstanone1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: Steroid hormone biosynthesis

This protein is involved in Steroid hormone biosynthesis.2 Publications
View all proteins of this organism that are known to be involved in Steroid hormone biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei309Substrate1
Binding sitei374Substrate; via amide nitrogen1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi437Iron (heme axial ligand)Combined sources1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
Biological processLipid metabolism
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
MetaCyc:HS06413-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.14.14.14, 2681

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
P11511

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-193144, Estrogen biosynthesis
R-HSA-211976, Endogenous sterols
R-HSA-5579030, Defective CYP19A1 causes AEXS

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P11511

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P11511

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001716

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Aromatase1 Publication (EC:1.14.14.142 Publications)
Alternative name(s):
CYPXIX
Cytochrome P-450AROM
Cytochrome P450 19A11 Publication
Estrogen synthase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CYP19A11 PublicationImported
Synonyms:ARO1, CYAR, CYP19
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2594, CYP19A1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
107910, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P11511

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000137869

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei19 – 39HelicalSequence analysisAdd BLAST21
Transmembranei303 – 323HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Aromatase excess syndrome (AEXS)
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant disorder characterized by increased extraglandular aromatization of steroids that presents with heterosexual precocity in males and isosexual precocity in females.
Related information in OMIM
Aromatase deficiency (AROD)4 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA rare disease in which fetal androgens are not converted into estrogens due to placental aromatase deficiency. Thus, pregnant women exhibit a hirsutism, which spontaneously resolves after post-partum. At birth, female babies present with pseudohermaphroditism due to virilization of extern genital organs. In adult females, manifestations include delay of puberty, breast hypoplasia and primary amenorrhoea with multicystic ovaries.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_072784192R → H in AROD; strongly reduced aromatase activity; 81% reduction of androstenedione metabolism compared to wild-type. 1 PublicationCorresponds to variant dbSNP:rs765057534Ensembl.1
Natural variantiVAR_016962365R → Q in AROD; 0.4% of wild-type activity. 1 PublicationCorresponds to variant dbSNP:rs80051519EnsemblClinVar.1
Natural variantiVAR_016963375R → C in AROD. 1 PublicationCorresponds to variant dbSNP:rs121434536EnsemblClinVar.1
Natural variantiVAR_016964435R → C in AROD; 1.1% of wild-type activity. 1 PublicationCorresponds to variant dbSNP:rs121434534EnsemblClinVar.1
Natural variantiVAR_016965437C → Y in AROD; complete loss of activity. 1 PublicationCorresponds to variant dbSNP:rs78310315EnsemblClinVar.1

Keywords - Diseasei

Disease variant, Pseudohermaphroditism

Organism-specific databases

DisGeNET

More...
DisGeNETi
1588

MalaCards human disease database

More...
MalaCardsi
CYP19A1
MIMi139300, phenotype
613546, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000137869

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
91, Aromatase deficiency
178345, Aromatase excess syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA27091

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
P11511, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL1978

Drug and drug target database

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DrugBanki
DB02342, 2-Methoxyestradiol
DB00357, Aminoglutethimide
DB01217, Anastrozole
DB00443, Betamethasone
DB04794, Bifonazole
DB06719, Buserelin
DB00389, Carbimazole
DB00269, Chlorotrianisene
DB00856, Chlorphenesin
DB04839, Cyproterone acetate
DB01406, Danazol
DB00255, Diethylstilbestrol
DB00858, Drostanolone
DB01127, Econazole
DB14598, Edetate calcium disodium anhydrous
DB14600, Edetate disodium anhydrous
DB00974, Edetic acid
DB06423, Endostatin
DB00655, Estrone
DB00926, Etretinate
DB00990, Exemestane
DB04539, Glyphosate
DB01026, Ketoconazole
DB01006, Letrozole
DB00358, Mefloquine
DB01065, Melatonin
DB00333, Methadone
DB06710, Methyltestosterone
DB01110, Miconazole
DB05749, MPI-674
DB08804, Nandrolone decanoate
DB03467, Naringenin
DB00184, Nicotine
DB09389, Norgestrel
DB01229, Paclitaxel
DB05804, Prasterone sulfate
DB00481, Raloxifene
DB05875, Sar9, Met (O2)11-Substance P
DB02901, Stanolone
DB06147, Sulfathiazole
DB00675, Tamoxifen
DB00894, Testolactone
DB00624, Testosterone
DB13943, Testosterone cypionate
DB13944, Testosterone enanthate
DB13946, Testosterone undecanoate
DB01007, Tioconazole
DB00197, Troglitazone

DrugCentral

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DrugCentrali
P11511

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
1362

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
CYP19A1

Domain mapping of disease mutations (DMDM)

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DMDMi
117293

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000519551 – 503AromataseAdd BLAST503

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated in vitro by PKA and PKG/PRKG1. These phosphorylations inhibit the catalytic activity as measured by estrone synthesis from androstenedione (36% decrease for PKA and 30% for PKG/PRKG1).1 Publication

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P11511

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P11511

PeptideAtlas

More...
PeptideAtlasi
P11511

PRoteomics IDEntifications database

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PRIDEi
P11511

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
52787 [P11511-1]
71189

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P11511

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P11511

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed, including in adult and fetal brain, placenta, skin fibroblasts, adipose tissue and gonads.4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000137869, Expressed in chorionic villus and 116 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P11511, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P11511, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000137869, Tissue enriched (placenta)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
107960, 8 interactors

Protein interaction database and analysis system

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IntActi
P11511, 6 interactors

Molecular INTeraction database

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MINTi
P11511

STRING: functional protein association networks

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STRINGi
9606.ENSP00000379683

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P11511

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P11511, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1503
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P11511

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P11511

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0157, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00840000129915

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_041874_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P11511

Identification of Orthologs from Complete Genome Data

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OMAi
VRPFFMK

Database for complete collections of gene phylogenies

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PhylomeDBi
P11511

TreeFam database of animal gene trees

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TreeFami
TF352039

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.630.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001128, Cyt_P450
IPR017972, Cyt_P450_CS
IPR002401, Cyt_P450_E_grp-I
IPR036396, Cyt_P450_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00067, p450, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00463, EP450I
PR00385, P450

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48264, SSF48264, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00086, CYTOCHROME_P450, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P11511-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVLEMLNPIH YNITSIVPEA MPAATMPVLL LTGLFLLVWN YEGTSSIPGP
60 70 80 90 100
GYCMGIGPLI SHGRFLWMGI GSACNYYNRV YGEFMRVWIS GEETLIISKS
110 120 130 140 150
SSMFHIMKHN HYSSRFGSKL GLQCIGMHEK GIIFNNNPEL WKTTRPFFMK
160 170 180 190 200
ALSGPGLVRM VTVCAESLKT HLDRLEEVTN ESGYVDVLTL LRRVMLDTSN
210 220 230 240 250
TLFLRIPLDE SAIVVKIQGY FDAWQALLIK PDIFFKISWL YKKYEKSVKD
260 270 280 290 300
LKDAIEVLIA EKRRRISTEE KLEECMDFAT ELILAEKRGD LTRENVNQCI
310 320 330 340 350
LEMLIAAPDT MSVSLFFMLF LIAKHPNVEE AIIKEIQTVI GERDIKIDDI
360 370 380 390 400
QKLKVMENFI YESMRYQPVV DLVMRKALED DVIDGYPVKK GTNIILNIGR
410 420 430 440 450
MHRLEFFPKP NEFTLENFAK NVPYRYFQPF GFGPRGCAGK YIAMVMMKAI
460 470 480 490 500
LVTLLRRFHV KTLQGQCVES IQKIHDLSLH PDETKNMLEM IFTPRNSDRC

LEH
Length:503
Mass (Da):57,883
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9BD9B28651D9A69A
GO
Isoform 2 (identifier: P11511-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     210-218: ESAIVVKIQ → GTEIFTLTS
     219-503: Missing.

Show »
Length:218
Mass (Da):24,518
Checksum:i9C15EFD1B411087C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PGZ6E9PGZ6_HUMAN
Aromatase
CYP19A1
166Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YK57H0YK57_HUMAN
Aromatase
CYP19A1
138Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YKN1H0YKN1_HUMAN
Aromatase
CYP19A1
172Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YLS2H0YLS2_HUMAN
Aromatase
CYP19A1
164Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EQ08E7EQ08_HUMAN
Aromatase
CYP19A1
352Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YLP1H0YLP1_HUMAN
Aromatase
CYP19A1
283Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YNJ7H0YNJ7_HUMAN
Aromatase
CYP19A1
244Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EPL6E7EPL6_HUMAN
Aromatase
CYP19A1
242Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WVQ0A0A087WVQ0_HUMAN
Aromatase
CYP19A1
41Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti496N → S in AAA35557 (PubMed:2973313).Curated1
Sequence conflicti496N → S in CAA31929 (PubMed:2973313).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02342839W → R2 PublicationsCorresponds to variant dbSNP:rs2236722EnsemblClinVar.1
Natural variantiVAR_072784192R → H in AROD; strongly reduced aromatase activity; 81% reduction of androstenedione metabolism compared to wild-type. 1 PublicationCorresponds to variant dbSNP:rs765057534Ensembl.1
Natural variantiVAR_023429201T → M2 PublicationsCorresponds to variant dbSNP:rs28757184EnsemblClinVar.1
Natural variantiVAR_018406264R → C 1.6 fold decrease in affinity for androstenedione substrate; slightly affects PKA-mediated reduction in catalytic activity as measured in vitro by estrone synthesis from androstenedione (49% decrease compared with 36% for the wild-type protein); no effect on PKG/PRKG1-mediated reduction in catalytic activity in vitro. 6 PublicationsCorresponds to variant dbSNP:rs700519EnsemblClinVar.1
Natural variantiVAR_077526264R → H 2.5 fold decrease in affinity for androstenedione substrate; slightly affects PKA-mediated reduction in catalytic activity as measured by estrone synthesis from androstenedione in vitro (28% decrease compared with 36% for the wild-type protein) and PKG/PRKG1-mediated reduction in catalytic activity in vitro (15% decrease compared with 30% for the wild-type protein). 1 PublicationCorresponds to variant dbSNP:rs2304462Ensembl.1
Natural variantiVAR_079486314S → P Found in deaf patients; unknown pathological significance. 1 Publication1
Natural variantiVAR_016962365R → Q in AROD; 0.4% of wild-type activity. 1 PublicationCorresponds to variant dbSNP:rs80051519EnsemblClinVar.1
Natural variantiVAR_016963375R → C in AROD. 1 PublicationCorresponds to variant dbSNP:rs121434536EnsemblClinVar.1
Natural variantiVAR_054152375R → L1 PublicationCorresponds to variant dbSNP:rs762631156Ensembl.1
Natural variantiVAR_016964435R → C in AROD; 1.1% of wild-type activity. 1 PublicationCorresponds to variant dbSNP:rs121434534EnsemblClinVar.1
Natural variantiVAR_016965437C → Y in AROD; complete loss of activity. 1 PublicationCorresponds to variant dbSNP:rs78310315EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_055583210 – 218ESAIVVKIQ → GTEIFTLTS in isoform 2. 1 Publication9
Alternative sequenceiVSP_055584219 – 503Missing in isoform 2. 1 PublicationAdd BLAST285

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M22246 mRNA Translation: AAA35557.1
X13589 mRNA Translation: CAA31929.1
M18856 mRNA Translation: AAA35556.1
J04127 mRNA Translation: AAA52132.1
Y07508 mRNA Translation: CAA68807.1
M30804 M30803 Genomic DNA Translation: AAA35728.1
AY957953 Genomic DNA Translation: AAX44046.1
AC012169 Genomic DNA No translation available.
AC020891 Genomic DNA No translation available.
BC035714 mRNA Translation: AAH35714.1
BC107785 mRNA Translation: AAI07786.1
M28420 mRNA Translation: AAA52141.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10139.1 [P11511-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
A34451, O4HU19

NCBI Reference Sequences

More...
RefSeqi
NP_000094.2, NM_000103.3 [P11511-1]
NP_001334177.1, NM_001347248.1 [P11511-1]
NP_001334178.1, NM_001347249.1 [P11511-1]
NP_001334179.1, NM_001347250.1 [P11511-1]
NP_001334180.1, NM_001347251.1 [P11511-1]
NP_001334181.1, NM_001347252.1 [P11511-1]
NP_001334182.1, NM_001347253.1 [P11511-1]
NP_001334183.1, NM_001347254.1 [P11511-1]
NP_001334184.1, NM_001347255.1 [P11511-1]
NP_001334185.1, NM_001347256.1 [P11511-1]
NP_112503.1, NM_031226.2 [P11511-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000396402; ENSP00000379683; ENSG00000137869 [P11511-1]
ENST00000396404; ENSP00000379685; ENSG00000137869 [P11511-1]
ENST00000405913; ENSP00000383930; ENSG00000137869 [P11511-2]
ENST00000557858; ENSP00000452627; ENSG00000137869 [P11511-2]
ENST00000559878; ENSP00000453149; ENSG00000137869 [P11511-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1588

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1588

UCSC genome browser

More...
UCSCi
uc001zyz.5, human [P11511-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Aromatase entry

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22246 mRNA Translation: AAA35557.1
X13589 mRNA Translation: CAA31929.1
M18856 mRNA Translation: AAA35556.1
J04127 mRNA Translation: AAA52132.1
Y07508 mRNA Translation: CAA68807.1
M30804 M30803 Genomic DNA Translation: AAA35728.1
AY957953 Genomic DNA Translation: AAX44046.1
AC012169 Genomic DNA No translation available.
AC020891 Genomic DNA No translation available.
BC035714 mRNA Translation: AAH35714.1
BC107785 mRNA Translation: AAI07786.1
M28420 mRNA Translation: AAA52141.1
CCDSiCCDS10139.1 [P11511-1]
PIRiA34451, O4HU19
RefSeqiNP_000094.2, NM_000103.3 [P11511-1]
NP_001334177.1, NM_001347248.1 [P11511-1]
NP_001334178.1, NM_001347249.1 [P11511-1]
NP_001334179.1, NM_001347250.1 [P11511-1]
NP_001334180.1, NM_001347251.1 [P11511-1]
NP_001334181.1, NM_001347252.1 [P11511-1]
NP_001334182.1, NM_001347253.1 [P11511-1]
NP_001334183.1, NM_001347254.1 [P11511-1]
NP_001334184.1, NM_001347255.1 [P11511-1]
NP_001334185.1, NM_001347256.1 [P11511-1]
NP_112503.1, NM_031226.2 [P11511-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TQAmodel-A53-495[»]
3EQMX-ray2.90A1-503[»]
3S79X-ray2.75A1-503[»]
3S7SX-ray3.21A1-503[»]
4GL5X-ray3.48A1-503[»]
4GL7X-ray3.90A1-503[»]
4KQ8X-ray3.29A45-503[»]
5JKVX-ray2.75A1-503[»]
5JKWX-ray3.00A1-503[»]
5JL6X-ray3.00A1-503[»]
5JL7X-ray3.10A1-503[»]
5JL9X-ray3.10A1-503[»]
SMRiP11511
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107960, 8 interactors
IntActiP11511, 6 interactors
MINTiP11511
STRINGi9606.ENSP00000379683

Chemistry databases

BindingDBiP11511
ChEMBLiCHEMBL1978
DrugBankiDB02342, 2-Methoxyestradiol
DB00357, Aminoglutethimide
DB01217, Anastrozole
DB00443, Betamethasone
DB04794, Bifonazole
DB06719, Buserelin
DB00389, Carbimazole
DB00269, Chlorotrianisene
DB00856, Chlorphenesin
DB04839, Cyproterone acetate
DB01406, Danazol
DB00255, Diethylstilbestrol
DB00858, Drostanolone
DB01127, Econazole
DB14598, Edetate calcium disodium anhydrous
DB14600, Edetate disodium anhydrous
DB00974, Edetic acid
DB06423, Endostatin
DB00655, Estrone
DB00926, Etretinate
DB00990, Exemestane
DB04539, Glyphosate
DB01026, Ketoconazole
DB01006, Letrozole
DB00358, Mefloquine
DB01065, Melatonin
DB00333, Methadone
DB06710, Methyltestosterone
DB01110, Miconazole
DB05749, MPI-674
DB08804, Nandrolone decanoate
DB03467, Naringenin
DB00184, Nicotine
DB09389, Norgestrel
DB01229, Paclitaxel
DB05804, Prasterone sulfate
DB00481, Raloxifene
DB05875, Sar9, Met (O2)11-Substance P
DB02901, Stanolone
DB06147, Sulfathiazole
DB00675, Tamoxifen
DB00894, Testolactone
DB00624, Testosterone
DB13943, Testosterone cypionate
DB13944, Testosterone enanthate
DB13946, Testosterone undecanoate
DB01007, Tioconazole
DB00197, Troglitazone
DrugCentraliP11511
GuidetoPHARMACOLOGYi1362
SwissLipidsiSLP:000001716

PTM databases

iPTMnetiP11511
PhosphoSitePlusiP11511

Genetic variation databases

BioMutaiCYP19A1
DMDMi117293

Proteomic databases

MassIVEiP11511
PaxDbiP11511
PeptideAtlasiP11511
PRIDEiP11511
ProteomicsDBi52787 [P11511-1]
71189

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
P11511, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
4371, 672 antibodies

The DNASU plasmid repository

More...
DNASUi
1588

Genome annotation databases

EnsembliENST00000396402; ENSP00000379683; ENSG00000137869 [P11511-1]
ENST00000396404; ENSP00000379685; ENSG00000137869 [P11511-1]
ENST00000405913; ENSP00000383930; ENSG00000137869 [P11511-2]
ENST00000557858; ENSP00000452627; ENSG00000137869 [P11511-2]
ENST00000559878; ENSP00000453149; ENSG00000137869 [P11511-1]
GeneIDi1588
KEGGihsa:1588
UCSCiuc001zyz.5, human [P11511-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1588
DisGeNETi1588

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CYP19A1
HGNCiHGNC:2594, CYP19A1
HPAiENSG00000137869, Tissue enriched (placenta)
MalaCardsiCYP19A1
MIMi107910, gene
139300, phenotype
613546, phenotype
neXtProtiNX_P11511
OpenTargetsiENSG00000137869
Orphaneti91, Aromatase deficiency
178345, Aromatase excess syndrome
PharmGKBiPA27091
VEuPathDBiHostDB:ENSG00000137869

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0157, Eukaryota
GeneTreeiENSGT00840000129915
HOGENOMiCLU_041874_0_0_1
InParanoidiP11511
OMAiVRPFFMK
PhylomeDBiP11511
TreeFamiTF352039

Enzyme and pathway databases

BioCyciMetaCyc:HS06413-MONOMER
BRENDAi1.14.14.14, 2681
PathwayCommonsiP11511
ReactomeiR-HSA-193144, Estrogen biosynthesis
R-HSA-211976, Endogenous sterols
R-HSA-5579030, Defective CYP19A1 causes AEXS
SABIO-RKiP11511
SIGNORiP11511

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
1588, 4 hits in 1009 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CYP19A1, human
EvolutionaryTraceiP11511

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Aromatase

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1588
PharosiP11511, Tclin

Protein Ontology

More...
PROi
PR:P11511
RNActiP11511, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000137869, Expressed in chorionic villus and 116 other tissues
ExpressionAtlasiP11511, baseline and differential
GenevisibleiP11511, HS

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128, Cyt_P450
IPR017972, Cyt_P450_CS
IPR002401, Cyt_P450_E_grp-I
IPR036396, Cyt_P450_sf
PfamiView protein in Pfam
PF00067, p450, 1 hit
PRINTSiPR00463, EP450I
PR00385, P450
SUPFAMiSSF48264, SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086, CYTOCHROME_P450, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCP19A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P11511
Secondary accession number(s): Q16731
, Q3B764, Q58FA0, Q8IYJ7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 23, 2007
Last modified: September 29, 2021
This is version 223 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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