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Protein

Cytochrome P450 2A6

Gene

CYP2A6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity.6 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.23 µM for coumarin2 Publications
  2. KM=530 µM for 1,4-cineole2 Publications
  1. Vmax=3.5 nmol/min/nmol enzyme toward 2-exo-hydroxy-1,4-cineole2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei107SubstrateCurated1
Binding sitei297Substrate1
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi439Iron (heme axial ligand)1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding, NADP

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS10343-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.14.14.1 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-211981 Xenobiotics
R-HSA-211999 CYP2E1 reactions

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P11509

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytochrome P450 2A6 (EC:1.14.13.-)
Alternative name(s):
1,4-cineole 2-exo-monooxygenase
CYPIIA6
Coumarin 7-hydroxylase
Cytochrome P450 IIA3
Cytochrome P450(I)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CYP2A6
Synonyms:CYP2A3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000255974.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2610 CYP2A6

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
122720 gene+phenotype

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P11509

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi208I → S: Increases phenacetin O-deethylation activity 10 fold; when associated with F-300 and A-301. Increases phenacetin O-deethylation activity 38 fold; when associated with F-300; A-301 and G-369. 1 Publication1
Mutagenesisi213S → A: No effect on phenacetin O-deethylation activity. 1 Publication1
Mutagenesisi300I → F: Increases phenacetin O-deethylation activity 3 fold. Increases phenacetin O-deethylation activity 8 fold; when associated with A-301. Increases phenacetin O-deethylation activity 10 fold; when associated with S-208 and A-301. Increases phenacetin O-deethylation activity 12 fold; when associated with A-301 and G-369. Increases phenacetin O-deethylation activity 38 fold; when associated with S-208; A-301 and G-369. 1 Publication1
Mutagenesisi301G → A: Slightly decreases phenacetin O-deethylation activity. Increases phenacetin O-deethylation activity 8 fold; when associated with F-300. Increases phenacetin O-deethylation activity 10 fold; when associated with S-208 and F-300. Increases phenacetin O-deethylation activity 12 fold; when associated with F-300 and G-369. Increases phenacetin O-deethylation activity 38 fold; when associated with S-208; F-300 and G-369. 1 Publication1
Mutagenesisi369S → G: Increases phenacetin O-deethylation activity 3 fold. Increases phenacetin O-deethylation activity 38 fold; when associated with S-208; F-300 and A-301. 1 Publication1
Mutagenesisi372R → H: Increases phenacetin O-deethylation activity 2 fold. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
1548

MalaCards human disease database

More...
MalaCardsi
CYP2A6
MIMi122720 gene+phenotype

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA121

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5282

Drug and drug target database

More...
DrugBanki
DB07621 (5-(PYRIDIN-3-YL)FURAN-2-YL)METHANAMINE
DB04665 2H-1-BENZOPYRAN-2-ONE
DB00316 Acetaminophen
DB01118 Amiodarone
DB00381 Amlodipine
DB01351 Amobarbital
DB00182 Amphetamine
DB01435 Antipyrine
DB01274 Arformoterol
DB00972 Azelastine
DB00207 Azithromycin
DB00921 Buprenorphine
DB01156 Bupropion
DB00356 Chlorzoxazone
DB00568 Cinnarizine
DB00604 Cisapride
DB00636 Clofibrate
DB00882 Clomifene
DB00257 Clotrimazole
DB00363 Clozapine
DB00531 Cyclophosphamide
DB06292 Dapagliflozin
DB01151 Desipramine
DB01234 Dexamethasone
DB01191 Dexfenfluramine
DB00255 Diethylstilbestrol
DB00470 Dronabinol
DB00216 Eletriptan
DB04953 Ezogabine
DB04841 Flunarizine
DB01544 Flunitrazepam
DB00544 Fluorouracil
DB00690 Flurazepam
DB01213 Fomepizole
DB00983 Formoterol
DB01159 Halothane
DB01181 Ifosfamide
DB00951 Isoniazid
DB01026 Ketoconazole
DB01006 Letrozole
DB00281 Lidocaine
DB04871 Lorcaserin
DB01043 Memantine
DB00170 Menadione
DB00763 Methimazole
DB00553 Methoxsalen
DB01028 Methoxyflurane
DB01011 Metyrapone
DB01110 Miconazole
DB00471 Montelukast
DB07617 N-METHYL(5-(PYRIDIN-3-YL)FURAN-2-YL)METHANAMINE
DB00238 Nevirapine
DB00184 Nicotine
DB01115 Nifedipine
DB06712 Nilvadipine
DB01059 Norfloxacin
DB00312 Pentobarbital
DB03783 Phenacetin
DB01174 Phenobarbital
DB01085 Pilocarpine
DB04977 Plitidepsin
DB00860 Prednisolone
DB00396 Progesterone
DB00818 Propofol
DB01045 Rifampicin
DB00412 Rosiglitazone
DB01037 Selegiline
DB01236 Sevoflurane
DB06729 Sulfaphenazole
DB00675 Tamoxifen
DB00752 Tranylcypromine
DB00755 Tretinoin
DB01361 Troleandomycin
DB00313 Valproic Acid
DB09068 Vortioxetine
DB00495 Zidovudine

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
1321

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
CYP2A6

Domain mapping of disease mutations (DMDM)

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DMDMi
308153612

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000516681 – 494Cytochrome P450 2A6Add BLAST494

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P11509

PeptideAtlas

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PeptideAtlasi
P11509

PRoteomics IDEntifications database

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PRIDEi
P11509

ProteomicsDB human proteome resource

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ProteomicsDBi
52786

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P11509

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P11509

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Liver.2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By phenobarbital and dexamethasone.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000255974 Expressed in 157 organ(s), highest expression level in right lobe of liver

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P11509 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P11509 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA046713
HPA047262

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
107927, 4 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000301141

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P11509

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1494
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P11509

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P11509

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P11509

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0156 Eukaryota
COG2124 LUCA

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG015789

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P11509

KEGG Orthology (KO)

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KOi
K17683

Database for complete collections of gene phylogenies

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PhylomeDBi
P11509

TreeFam database of animal gene trees

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TreeFami
TF352043

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.630.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR008067 Cyt_P450_E_grp-I_CYP2A-like
IPR036396 Cyt_P450_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00067 p450, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00463 EP450I
PR01684 EP450ICYP2A
PR00385 P450

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48264 SSF48264, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P11509-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLASGMLLVA LLVCLTVMVL MSVWQQRKSK GKLPPGPTPL PFIGNYLQLN
60 70 80 90 100
TEQMYNSLMK ISERYGPVFT IHLGPRRVVV LCGHDAVREA LVDQAEEFSG
110 120 130 140 150
RGEQATFDWV FKGYGVVFSN GERAKQLRRF SIATLRDFGV GKRGIEERIQ
160 170 180 190 200
EEAGFLIDAL RGTGGANIDP TFFLSRTVSN VISSIVFGDR FDYKDKEFLS
210 220 230 240 250
LLRMMLGIFQ FTSTSTGQLY EMFSSVMKHL PGPQQQAFQL LQGLEDFIAK
260 270 280 290 300
KVEHNQRTLD PNSPRDFIDS FLIRMQEEEK NPNTEFYLKN LVMTTLNLFI
310 320 330 340 350
GGTETVSTTL RYGFLLLMKH PEVEAKVHEE IDRVIGKNRQ PKFEDRAKMP
360 370 380 390 400
YMEAVIHEIQ RFGDVIPMSL ARRVKKDTKF RDFFLPKGTE VFPMLGSVLR
410 420 430 440 450
DPSFFSNPQD FNPQHFLNEK GQFKKSDAFV PFSIGKRNCF GEGLARMELF
460 470 480 490
LFFTTVMQNF RLKSSQSPKD IDVSPKHVGF ATIPRNYTMS FLPR
Length:494
Mass (Da):56,501
Last modified:October 5, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8C05CBF0EFC698AF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R2Z4M0R2Z4_HUMAN
Cytochrome P450 2A6
CYP2A6
65Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA52147 differs from that shown. Numerous conflicts and frameshifts.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti3 – 7Missing in CAA32097 (PubMed:2726448).Curated5
Sequence conflicti255N → K in CAA32097 (PubMed:2726448).Curated1
Sequence conflicti326K → Q in CAA32097 (PubMed:2726448).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0183305G → R in allele CYP2A6*13. 2 PublicationsCorresponds to variant dbSNP:rs28399434Ensembl.1
Natural variantiVAR_01833129S → N in allele CYP2A6*14. 3 PublicationsCorresponds to variant dbSNP:rs28399435Ensembl.1
Natural variantiVAR_055035110V → L in allele CYP2A6*24; increases phenacetin O-deethylation activity 4 fold. 2 PublicationsCorresponds to variant dbSNP:rs72549435Ensembl.1
Natural variantiVAR_024711118F → L in allele CYP2A6*25 and allele CYP2A6*26. 2 PublicationsCorresponds to variant dbSNP:rs28399440Ensembl.1
Natural variantiVAR_055036128R → L in allele CYP2A6*26. 1 Publication1
Natural variantiVAR_011577128R → Q in allele CYP2A6*6; loss of activity. 2 PublicationsCorresponds to variant dbSNP:rs4986891Ensembl.1
Natural variantiVAR_055037131S → A in allele CYP2A6*26. 1 PublicationCorresponds to variant dbSNP:rs59552350Ensembl.1
Natural variantiVAR_001249160L → H in allele CYP2A6*2; unable to catalyze 7-hydroxylation of coumarin; causes switching from coumarin 7-hydroxylation to 3-hydroxylation. 5 PublicationsCorresponds to variant dbSNP:rs1801272EnsemblClinVar.1
Natural variantiVAR_018332194K → E in allele CYP2A6*15. 1 Publication1
Natural variantiVAR_055034203R → C in allele CYP2A6*23; greatly reduced activity toward nicotine C-oxidation as well as reduced coumarin 7-hydroxylation. 2 PublicationsCorresponds to variant dbSNP:rs56256500Ensembl.1
Natural variantiVAR_018333203R → S in allele CYP2A6*16. 2 PublicationsCorresponds to variant dbSNP:rs56256500Ensembl.1
Natural variantiVAR_024712224S → P1 PublicationCorresponds to variant dbSNP:rs28399447EnsemblClinVar.1
Natural variantiVAR_059149292V → M. Corresponds to variant dbSNP:rs2644906Ensembl.1
Natural variantiVAR_048448294T → S. Corresponds to variant dbSNP:rs4997557Ensembl.1
Natural variantiVAR_024713365V → M in allele CYP2A6*17; increases phenacetin O-deethylation activity 2 fold. 4 PublicationsCorresponds to variant dbSNP:rs28399454Ensembl.1
Natural variantiVAR_055033392F → Y9 PublicationsCorresponds to variant dbSNP:rs1809810Ensembl.1
Natural variantiVAR_024714418N → D in allele CYP2A6*28. 3 PublicationsCorresponds to variant dbSNP:rs28399463Ensembl.1
Natural variantiVAR_018375419E → D in allele CYP2A6*28. 4 PublicationsCorresponds to variant dbSNP:rs8192730Ensembl.1
Natural variantiVAR_055038438N → Y in allele CYP2A6*24. 1 Publication1
Natural variantiVAR_011578471I → T in allele CYP2A6*7. 3 PublicationsCorresponds to variant dbSNP:rs5031016Ensembl.1
Natural variantiVAR_024715476K → R2 PublicationsCorresponds to variant dbSNP:rs6413474Ensembl.1
Natural variantiVAR_008356479G → V in allele CYP2A6*5; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs5031017Ensembl.1
Natural variantiVAR_011579485R → L in allele CYP2A6*8. 2 PublicationsCorresponds to variant dbSNP:rs28399468Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X13897 mRNA Translation: CAA32097.1
X13929 mRNA Translation: CAA32117.1
X13930 mRNA Translation: CAA32118.1
M33318 mRNA Translation: AAA52067.1
AF182275 mRNA Translation: AAF13600.1
AK312964 mRNA Translation: BAG35803.1
EU135979 Genomic DNA Translation: ABV02584.1
FJ440681 Genomic DNA Translation: ACK44068.1
AC008537 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW57012.1
BC096253 mRNA Translation: AAH96253.3
BC096254 mRNA Translation: AAH96254.1
BC096255 mRNA Translation: AAH96255.1
BC096256 mRNA Translation: AAH96256.1
AF326721 Genomic DNA Translation: AAG45229.1
K03192 mRNA Translation: AAA52147.1 Sequence problems.

The Consensus CDS (CCDS) project

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CCDSi
CCDS12568.1

Protein sequence database of the Protein Information Resource

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PIRi
A00190 O4HUPB
S04698 O4HUA6

NCBI Reference Sequences

More...
RefSeqi
NP_000753.3, NM_000762.5

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.250615

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000301141; ENSP00000301141; ENSG00000255974

Database of genes from NCBI RefSeq genomes

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GeneIDi
1548

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:1548

UCSC genome browser

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UCSCi
uc002opl.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Cytochrome P450 Allele Nomenclature Committee

CYP2A6 alleles

NIEHS-SNPs
Wikipedia

CYP2A6 entry

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13897 mRNA Translation: CAA32097.1
X13929 mRNA Translation: CAA32117.1
X13930 mRNA Translation: CAA32118.1
M33318 mRNA Translation: AAA52067.1
AF182275 mRNA Translation: AAF13600.1
AK312964 mRNA Translation: BAG35803.1
EU135979 Genomic DNA Translation: ABV02584.1
FJ440681 Genomic DNA Translation: ACK44068.1
AC008537 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW57012.1
BC096253 mRNA Translation: AAH96253.3
BC096254 mRNA Translation: AAH96254.1
BC096255 mRNA Translation: AAH96255.1
BC096256 mRNA Translation: AAH96256.1
AF326721 Genomic DNA Translation: AAG45229.1
K03192 mRNA Translation: AAA52147.1 Sequence problems.
CCDSiCCDS12568.1
PIRiA00190 O4HUPB
S04698 O4HUA6
RefSeqiNP_000753.3, NM_000762.5
UniGeneiHs.250615

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Z10X-ray1.90A/B/C/D29-494[»]
1Z11X-ray2.05A/B/C/D29-494[»]
2FDUX-ray1.85A/B/C/D29-494[»]
2FDVX-ray1.65A/B/C/D29-494[»]
2FDWX-ray2.05A/B/C/D29-494[»]
2FDYX-ray1.95A/B/C/D29-494[»]
3EBSX-ray2.15A/B/C/D29-494[»]
3T3QX-ray2.10A/B/C/D29-494[»]
3T3RX-ray2.40A/B/C/D29-494[»]
4EJJX-ray2.30A/B/C/D29-494[»]
4RUIX-ray2.61A/B/C/D/E/F29-494[»]
ProteinModelPortaliP11509
SMRiP11509
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107927, 4 interactors
STRINGi9606.ENSP00000301141

Chemistry databases

BindingDBiP11509
ChEMBLiCHEMBL5282
DrugBankiDB07621 (5-(PYRIDIN-3-YL)FURAN-2-YL)METHANAMINE
DB04665 2H-1-BENZOPYRAN-2-ONE
DB00316 Acetaminophen
DB01118 Amiodarone
DB00381 Amlodipine
DB01351 Amobarbital
DB00182 Amphetamine
DB01435 Antipyrine
DB01274 Arformoterol
DB00972 Azelastine
DB00207 Azithromycin
DB00921 Buprenorphine
DB01156 Bupropion
DB00356 Chlorzoxazone
DB00568 Cinnarizine
DB00604 Cisapride
DB00636 Clofibrate
DB00882 Clomifene
DB00257 Clotrimazole
DB00363 Clozapine
DB00531 Cyclophosphamide
DB06292 Dapagliflozin
DB01151 Desipramine
DB01234 Dexamethasone
DB01191 Dexfenfluramine
DB00255 Diethylstilbestrol
DB00470 Dronabinol
DB00216 Eletriptan
DB04953 Ezogabine
DB04841 Flunarizine
DB01544 Flunitrazepam
DB00544 Fluorouracil
DB00690 Flurazepam
DB01213 Fomepizole
DB00983 Formoterol
DB01159 Halothane
DB01181 Ifosfamide
DB00951 Isoniazid
DB01026 Ketoconazole
DB01006 Letrozole
DB00281 Lidocaine
DB04871 Lorcaserin
DB01043 Memantine
DB00170 Menadione
DB00763 Methimazole
DB00553 Methoxsalen
DB01028 Methoxyflurane
DB01011 Metyrapone
DB01110 Miconazole
DB00471 Montelukast
DB07617 N-METHYL(5-(PYRIDIN-3-YL)FURAN-2-YL)METHANAMINE
DB00238 Nevirapine
DB00184 Nicotine
DB01115 Nifedipine
DB06712 Nilvadipine
DB01059 Norfloxacin
DB00312 Pentobarbital
DB03783 Phenacetin
DB01174 Phenobarbital
DB01085 Pilocarpine
DB04977 Plitidepsin
DB00860 Prednisolone
DB00396 Progesterone
DB00818 Propofol
DB01045 Rifampicin
DB00412 Rosiglitazone
DB01037 Selegiline
DB01236 Sevoflurane
DB06729 Sulfaphenazole
DB00675 Tamoxifen
DB00752 Tranylcypromine
DB00755 Tretinoin
DB01361 Troleandomycin
DB00313 Valproic Acid
DB09068 Vortioxetine
DB00495 Zidovudine
GuidetoPHARMACOLOGYi1321

PTM databases

iPTMnetiP11509
PhosphoSitePlusiP11509

Polymorphism and mutation databases

BioMutaiCYP2A6
DMDMi308153612

Proteomic databases

PaxDbiP11509
PeptideAtlasiP11509
PRIDEiP11509
ProteomicsDBi52786

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1548
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301141; ENSP00000301141; ENSG00000255974
GeneIDi1548
KEGGihsa:1548
UCSCiuc002opl.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1548
DisGeNETi1548
EuPathDBiHostDB:ENSG00000255974.6

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CYP2A6
HGNCiHGNC:2610 CYP2A6
HPAiHPA046713
HPA047262
MalaCardsiCYP2A6
MIMi122720 gene+phenotype
neXtProtiNX_P11509
PharmGKBiPA121

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
HOVERGENiHBG015789
InParanoidiP11509
KOiK17683
PhylomeDBiP11509
TreeFamiTF352043

Enzyme and pathway databases

BioCyciMetaCyc:HS10343-MONOMER
BRENDAi1.14.14.1 2681
ReactomeiR-HSA-211981 Xenobiotics
R-HSA-211999 CYP2E1 reactions
SABIO-RKiP11509

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CYP2A6 human
EvolutionaryTraceiP11509

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CYP2A6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
1548

Protein Ontology

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PROi
PR:P11509

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000255974 Expressed in 157 organ(s), highest expression level in right lobe of liver
ExpressionAtlasiP11509 baseline and differential
GenevisibleiP11509 HS

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR008067 Cyt_P450_E_grp-I_CYP2A-like
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR01684 EP450ICYP2A
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCP2A6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P11509
Secondary accession number(s): A7YAE5
, B2R7F6, P00190, P10890, Q16803, Q4VAT9, Q4VAU0, Q4VAU1, Q9H1Z7, Q9UCU0, Q9UK48
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 5, 2010
Last modified: December 5, 2018
This is version 210 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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