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UniProtKB - P11498 (PYC_HUMAN)

Entry version 218 (16 Oct 2019)
Sequence version 2 (01 Oct 1996)
Previous versions | rss
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Protein

Pyruvate carboxylase, mitochondrial

Gene

PC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei152ATPBy similarity1
Binding sitei236ATPBy similarity1
Binding sitei271ATPBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei328By similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi572Manganese1 Publication1
Binding sitei644Substrate1
Metal bindingi741Manganese; via carbamate group1 Publication1
Metal bindingi771Manganese; via tele nitrogen1 Publication1
Metal bindingi773Manganese; via tele nitrogen1 Publication1
Binding sitei908Substrate1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase, Multifunctional enzyme
Biological processGluconeogenesis, Lipid biosynthesis, Lipid metabolism
LigandATP-binding, Biotin, Manganese, Metal-binding, Nucleotide-binding, Pyruvate

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS10697-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		6.4.1.1 2681

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-196780 Biotin transport and metabolism
R-HSA-3371599 Defective HLCS causes multiple carboxylase deficiency
R-HSA-70263 Gluconeogenesis

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		P11498

SIGNOR Signaling Network Open Resource

More...SIGNORi		P11498

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00138

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pyruvate carboxylase, mitochondrial (EC:6.4.1.1)
Alternative name(s):
Pyruvic carboxylase
Short name:
PCB
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PC
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:8636 PC

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		608786 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P11498

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Pyruvate carboxylase deficiency (PC deficiency)
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionLeads to lactic acidosis, mental retardation and death. It occurs in three forms: mild or type A, severe neonatal or type B, and a very mild lacticacidemia.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_015199145V → A in PC deficiency; mild. 2 PublicationsCorresponds to variant dbSNP:rs28940591EnsemblClinVar.1
Natural variantiVAR_058957156R → Q in PC deficiency. 1 PublicationCorresponds to variant dbSNP:rs119103241EnsemblClinVar.1
Natural variantiVAR_058958270R → W in PC deficiency. 1 PublicationCorresponds to variant dbSNP:rs1258494752Ensembl.1
Natural variantiVAR_058959304Y → C in PC deficiency. 1 Publication1
Natural variantiVAR_015200451R → C in PC deficiency; mild. 2 PublicationsCorresponds to variant dbSNP:rs113994143EnsemblClinVar.1
Natural variantiVAR_058960583R → L in PC deficiency. 1 PublicationCorresponds to variant dbSNP:rs119103242EnsemblClinVar.1
Natural variantiVAR_008095610A → T in PC deficiency; mild. 2 PublicationsCorresponds to variant dbSNP:rs28940589EnsemblClinVar.1
Natural variantiVAR_058961631R → Q in PC deficiency. 1 PublicationCorresponds to variant dbSNP:rs113994145EnsemblClinVar.1
Natural variantiVAR_008096743M → I in PC deficiency; mild. 2 PublicationsCorresponds to variant dbSNP:rs28940590EnsemblClinVar.1
Natural variantiVAR_0589621131 – 1133Missing in PC deficiency. 1 Publication3

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1077F → A or E: Loss of tetramerization and enzyme activity, resulting in an inactive homodimer. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...DisGeNETi		5091

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		PC

MalaCards human disease database

More...MalaCardsi		PC
MIMi266150 phenotype

Open Targets

More...OpenTargetsi		ENSG00000173599

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		353320 Pyruvate carboxylase deficiency, benign type
353308 Pyruvate carboxylase deficiency, infantile type
353314 Pyruvate carboxylase deficiency, severe neonatal type

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA32975

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P11498

Chemistry databases

Drug and drug target database

More...DrugBanki		DB07497 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL
DB00121 Biotin
DB00119 Pyruvic acid

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PC

Domain mapping of disease mutations (DMDM)

More...DMDMi		1709947

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 20MitochondrionSequence analysisAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000284021 – 1178Pyruvate carboxylase, mitochondrialAdd BLAST1158

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei35N6-acetyllysineBy similarity1
Modified residuei39N6-acetyllysineBy similarity1
Modified residuei79N6-acetyllysine; alternateBy similarity1
Modified residuei79N6-succinyllysine; alternateBy similarity1
Modified residuei148N6-acetyllysineBy similarity1
Modified residuei152N6-acetyllysineBy similarity1
Modified residuei241N6-acetyllysineBy similarity1
Modified residuei297N6-acetyllysineBy similarity1
Modified residuei319N6-acetyllysineBy similarity1
Modified residuei434N6-acetyllysineBy similarity1
Modified residuei442N6-succinyllysineBy similarity1
Modified residuei589N6-acetyllysineBy similarity1
Modified residuei661N6-acetyllysineBy similarity1
Modified residuei717N6-acetyllysineBy similarity1
Modified residuei741N6-carboxylysine1 Publication1
Modified residuei748N6-acetyllysineBy similarity1
Modified residuei892N6-acetyllysineBy similarity1
Modified residuei969N6-acetyllysineBy similarity1
Modified residuei992N6-acetyllysineBy similarity1
Modified residuei1003PhosphothreonineBy similarity1
Modified residuei1061N6-acetyllysineBy similarity1
Modified residuei1090N6-acetyllysineCombined sources1
Modified residuei1124N6-acetyllysineBy similarity1
Modified residuei1144N6-biotinyllysinePROSITE-ProRule annotation2 Publications1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Acetylation of Lys-748 might play a role in catalytic activity regulation.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P11498

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P11498

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P11498

MaxQB - The MaxQuant DataBase

More...MaxQBi		P11498

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P11498

PeptideAtlas

More...PeptideAtlasi		P11498

PRoteomics IDEntifications database

More...PRIDEi		P11498

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		4659
52785 [P11498-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P11498

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P11498

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P11498

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000173599 Expressed in 160 organ(s), highest expression level in right lobe of liver

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P11498 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P11498 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		CAB033742
HPA043922
HPA058765

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer (PubMed:18297087).

Interacts (via the biotin carboxylation domain) with SIRT4 (PubMed:23438705).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		111124, 81 interactors

Database of interacting proteins

More...DIPi		DIP-46372N

Protein interaction database and analysis system

More...IntActi		P11498, 30 interactors

Molecular INTeraction database

More...MINTi		P11498

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000377532

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11178
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P11498

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P11498

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini36 – 486Biotin carboxylationAdd BLAST451
Domaini156 – 353ATP-graspPROSITE-ProRule annotationAdd BLAST198
Domaini563 – 832Pyruvate carboxyltransferasePROSITE-ProRule annotationAdd BLAST270
Domaini1109 – 1178Biotinyl-bindingPROSITE-ProRule annotationAdd BLAST70

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni571 – 575Substrate binding5

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IU5D Eukaryota
COG1038 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00900000141164

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000282801

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P11498

KEGG Orthology (KO)

More...KOi		K01958

Database of Orthologous Groups

More...OrthoDBi		254436at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P11498

TreeFam database of animal gene trees

More...TreeFami		TF300535

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.20.20.70, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013785 Aldolase_TIM
IPR011761 ATP-grasp
IPR005481 BC-like_N
IPR001882 Biotin_BS
IPR011764 Biotin_carboxylation_dom
IPR005482 Biotin_COase_C
IPR000089 Biotin_lipoyl
IPR003379 Carboxylase_cons_dom
IPR005479 CbamoylP_synth_lsu-like_ATP-bd
IPR016185 PreATP-grasp_dom_sf
IPR000891 PYR_CT
IPR005930 Pyruv_COase
IPR011054 Rudment_hybrid_motif
IPR011053 Single_hybrid_motif

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02785 Biotin_carb_C, 1 hit
PF00289 Biotin_carb_N, 1 hit
PF00364 Biotin_lipoyl, 1 hit
PF02786 CPSase_L_D2, 1 hit
PF00682 HMGL-like, 1 hit
PF02436 PYC_OADA, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF001594 Pyruv_carbox, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00878 Biotin_carb_C, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF51230 SSF51230, 1 hit
SSF51246 SSF51246, 1 hit
SSF52440 SSF52440, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01235 pyruv_carbox, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS50979 BC, 1 hit
PS00188 BIOTIN, 1 hit
PS50968 BIOTINYL_LIPOYL, 1 hit
PS50991 PYR_CT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P11498-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLKFRTVHGG LRLLGIRRTS TAPAASPNVR RLEYKPIKKV MVANRGEIAI 
        60         70         80         90        100
RVFRACTELG IRTVAIYSEQ DTGQMHRQKA DEAYLIGRGL APVQAYLHIP 
       110        120        130        140        150
DIIKVAKENN VDAVHPGYGF LSERADFAQA CQDAGVRFIG PSPEVVRKMG 
       160        170        180        190        200
DKVEARAIAI AAGVPVVPGT DAPITSLHEA HEFSNTYGFP IIFKAAYGGG 
       210        220        230        240        250
GRGMRVVHSY EELEENYTRA YSEALAAFGN GALFVEKFIE KPRHIEVQIL 
       260        270        280        290        300
GDQYGNILHL YERDCSIQRR HQKVVEIAPA AHLDPQLRTR LTSDSVKLAK 
       310        320        330        340        350
QVGYENAGTV EFLVDRHGKH YFIEVNSRLQ VEHTVTEEIT DVDLVHAQIH 
       360        370        380        390        400
VAEGRSLPDL GLRQENIRIN GCAIQCRVTT EDPARSFQPD TGRIEVFRSG 
       410        420        430        440        450
EGMGIRLDNA SAFQGAVISP HYDSLLVKVI AHGKDHPTAA TKMSRALAEF 
       460        470        480        490        500
RVRGVKTNIA FLQNVLNNQQ FLAGTVDTQF IDENPELFQL RPAQNRAQKL 
       510        520        530        540        550
LHYLGHVMVN GPTTPIPVKA SPSPTDPVVP AVPIGPPPAG FRDILLREGP 
       560        570        580        590        600
EGFARAVRNH PGLLLMDTTF RDAHQSLLAT RVRTHDLKKI APYVAHNFSK 
       610        620        630        640        650
LFSMENWGGA TFDVAMRFLY ECPWRRLQEL RELIPNIPFQ MLLRGANAVG 
       660        670        680        690        700
YTNYPDNVVF KFCEVAKENG MDVFRVFDSL NYLPNMLLGM EAAGSAGGVV 
       710        720        730        740        750
EAAISYTGDV ADPSRTKYSL QYYMGLAEEL VRAGTHILCI KDMAGLLKPT 
       760        770        780        790        800
ACTMLVSSLR DRFPDLPLHI HTHDTSGAGV AAMLACAQAG ADVVDVAADS 
       810        820        830        840        850
MSGMTSQPSM GALVACTRGT PLDTEVPMER VFDYSEYWEG ARGLYAAFDC 
       860        870        880        890        900
TATMKSGNSD VYENEIPGGQ YTNLHFQAHS MGLGSKFKEV KKAYVEANQM 
       910        920        930        940        950
LGDLIKVTPS SKIVGDLAQF MVQNGLSRAE AEAQAEELSF PRSVVEFLQG 
       960        970        980        990       1000
YIGVPHGGFP EPFRSKVLKD LPRVEGRPGA SLPPLDLQAL EKELVDRHGE 
      1010       1020       1030       1040       1050
EVTPEDVLSA AMYPDVFAHF KDFTATFGPL DSLNTRLFLQ GPKIAEEFEV 
      1060       1070       1080       1090       1100
ELERGKTLHI KALAVSDLNR AGQRQVFFEL NGQLRSILVK DTQAMKEMHF 
      1110       1120       1130       1140       1150
HPKALKDVKG QIGAPMPGKV IDIKVVAGAK VAKGQPLCVL SAMKMETVVT 
      1160       1170 
SPMEGTVRKV HVTKDMTLEG DDLILEIE
Length:1,178
Mass (Da):129,634
Last modified:October 1, 1996 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i381F527553A20095
GO
Isoform 2 (identifier: P11498-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     457-529: TNIAFLQNVL...ASPSPTDPVV → VRRHQAQPLA...STEVSPTILL
     530-1178: Missing.

Note: No experimental confirmation available.
Show »
Length:529
Mass (Da):57,925
Checksum:i35B87A653BF6F9C3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A494C016A0A494C016_HUMAN
Pyruvate carboxylase, mitochondrial
PC
631Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PRE7E9PRE7_HUMAN
Pyruvate carboxylase, mitochondrial
PC
489Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C0T2A0A494C0T2_HUMAN
Pyruvate carboxylase, mitochondrial
PC
531Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C101A0A494C101_HUMAN
Pyruvate carboxylase, mitochondrial
PC
483Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494BZT5A0A494BZT5_HUMAN
Pyruvate carboxylase, mitochondrial
PC
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti225 – 226LA → WP in AAB31500 (PubMed:8048912).Curated2
Sequence conflicti352A → S in AAA82937 (Ref. 3) Curated1
Sequence conflicti385 – 386RS → PT in AAB31500 (PubMed:8048912).Curated2
Sequence conflicti486 – 487EL → DV in AAB31500 (PubMed:8048912).Curated2
Sequence conflicti638P → R in AAB31500 (PubMed:8048912).Curated1
Sequence conflicti729E → A in AAB31500 (PubMed:8048912).Curated1
Sequence conflicti774 – 775DT → AP in AAB31500 (PubMed:8048912).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04841676H → L. Corresponds to variant dbSNP:rs7104156EnsemblClinVar.1
Natural variantiVAR_015199145V → A in PC deficiency; mild. 2 PublicationsCorresponds to variant dbSNP:rs28940591EnsemblClinVar.1
Natural variantiVAR_058957156R → Q in PC deficiency. 1 PublicationCorresponds to variant dbSNP:rs119103241EnsemblClinVar.1
Natural variantiVAR_058958270R → W in PC deficiency. 1 PublicationCorresponds to variant dbSNP:rs1258494752Ensembl.1
Natural variantiVAR_058959304Y → C in PC deficiency. 1 Publication1
Natural variantiVAR_015200451R → C in PC deficiency; mild. 2 PublicationsCorresponds to variant dbSNP:rs113994143EnsemblClinVar.1
Natural variantiVAR_058960583R → L in PC deficiency. 1 PublicationCorresponds to variant dbSNP:rs119103242EnsemblClinVar.1
Natural variantiVAR_008095610A → T in PC deficiency; mild. 2 PublicationsCorresponds to variant dbSNP:rs28940589EnsemblClinVar.1
Natural variantiVAR_058961631R → Q in PC deficiency. 1 PublicationCorresponds to variant dbSNP:rs113994145EnsemblClinVar.1
Natural variantiVAR_008096743M → I in PC deficiency; mild. 2 PublicationsCorresponds to variant dbSNP:rs28940590EnsemblClinVar.1
Natural variantiVAR_0589621131 – 1133Missing in PC deficiency. 1 Publication3

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_056358457 – 529TNIAF…TDPVV → VRRHQAQPLAAALGRPCGQE ARRPQAAVTAPTGPGSPTLV RVPPAARVLSSRLGGPSQTT PETSTEVSPTILL in isoform 2. 1 PublicationAdd BLAST73
Alternative sequenceiVSP_056359530 – 1178Missing in isoform 2. 1 PublicationAdd BLAST649

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U04641 mRNA Translation: AAA99537.1
S72370 mRNA Translation: AAB31500.1
U30891 mRNA Translation: AAA82937.1
AK297705 mRNA Translation: BAG60062.1
AP000485 Genomic DNA No translation available.
AP003176 Genomic DNA No translation available.
BC011617 mRNA Translation: AAH11617.1
M26122 mRNA Translation: AAA36423.1
K02282 mRNA Translation: AAA60033.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS8152.1 [P11498-1]

Protein sequence database of the Protein Information Resource

More...PIRi		G01933 JC2460

NCBI Reference Sequences

More...RefSeqi		NP_000911.2, NM_000920.3 [P11498-1]
NP_001035806.1, NM_001040716.1 [P11498-1]
NP_071504.2, NM_022172.2 [P11498-1]
XP_005274088.1, XM_005274031.4 [P11498-1]
XP_005274089.1, XM_005274032.4 [P11498-1]
XP_006718641.1, XM_006718578.3 [P11498-1]
XP_011543388.1, XM_011545086.2 [P11498-1]
XP_016873357.1, XM_017017868.1 [P11498-1]
XP_016873358.1, XM_017017869.1 [P11498-1]
XP_016873359.1, XM_017017870.1 [P11498-1]
XP_016873360.1, XM_017017871.1 [P11498-1]
XP_016873361.1, XM_017017872.1 [P11498-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000393955; ENSP00000377527; ENSG00000173599 [P11498-1]
ENST00000393958; ENSP00000377530; ENSG00000173599 [P11498-1]
ENST00000393960; ENSP00000377532; ENSG00000173599 [P11498-1]
ENST00000524491; ENSP00000434192; ENSG00000173599 [P11498-2]
ENST00000529047; ENSP00000435905; ENSG00000173599 [P11498-1]
ENST00000651036; ENSP00000498406; ENSG00000173599 [P11498-1]
ENST00000651854; ENSP00000498994; ENSG00000173599 [P11498-1]
ENST00000652125; ENSP00000498302; ENSG00000173599 [P11498-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5091

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5091

UCSC genome browser

More...UCSCi		uc001ojn.2 human [P11498-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Pyruvate carboxylase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04641 mRNA Translation: AAA99537.1
S72370 mRNA Translation: AAB31500.1
U30891 mRNA Translation: AAA82937.1
AK297705 mRNA Translation: BAG60062.1
AP000485 Genomic DNA No translation available.
AP003176 Genomic DNA No translation available.
BC011617 mRNA Translation: AAH11617.1
M26122 mRNA Translation: AAA36423.1
K02282 mRNA Translation: AAA60033.1
CCDSiCCDS8152.1 [P11498-1]
PIRiG01933 JC2460
RefSeqiNP_000911.2, NM_000920.3 [P11498-1]
NP_001035806.1, NM_001040716.1 [P11498-1]
NP_071504.2, NM_022172.2 [P11498-1]
XP_005274088.1, XM_005274031.4 [P11498-1]
XP_005274089.1, XM_005274032.4 [P11498-1]
XP_006718641.1, XM_006718578.3 [P11498-1]
XP_011543388.1, XM_011545086.2 [P11498-1]
XP_016873357.1, XM_017017868.1 [P11498-1]
XP_016873358.1, XM_017017869.1 [P11498-1]
XP_016873359.1, XM_017017870.1 [P11498-1]
XP_016873360.1, XM_017017871.1 [P11498-1]
XP_016873361.1, XM_017017872.1 [P11498-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BG3X-ray2.80A/B/C/D482-1178[»]
3BG9X-ray3.00A/B/C/D482-1178[»]
SMRiP11498
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi111124, 81 interactors
DIPiDIP-46372N
IntActiP11498, 30 interactors
MINTiP11498
STRINGi9606.ENSP00000377532

Chemistry databases

DrugBankiDB07497 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL
DB00121 Biotin
DB00119 Pyruvic acid

PTM databases

iPTMnetiP11498
PhosphoSitePlusiP11498
SwissPalmiP11498

Polymorphism and mutation databases

BioMutaiPC
DMDMi1709947

Proteomic databases

EPDiP11498
jPOSTiP11498
MassIVEiP11498
MaxQBiP11498
PaxDbiP11498
PeptideAtlasiP11498
PRIDEiP11498
ProteomicsDBi4659
52785 [P11498-1]

Genome annotation databases

EnsembliENST00000393955; ENSP00000377527; ENSG00000173599 [P11498-1]
ENST00000393958; ENSP00000377530; ENSG00000173599 [P11498-1]
ENST00000393960; ENSP00000377532; ENSG00000173599 [P11498-1]
ENST00000524491; ENSP00000434192; ENSG00000173599 [P11498-2]
ENST00000529047; ENSP00000435905; ENSG00000173599 [P11498-1]
ENST00000651036; ENSP00000498406; ENSG00000173599 [P11498-1]
ENST00000651854; ENSP00000498994; ENSG00000173599 [P11498-1]
ENST00000652125; ENSP00000498302; ENSG00000173599 [P11498-1]
GeneIDi5091
KEGGihsa:5091
UCSCiuc001ojn.2 human [P11498-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5091
DisGeNETi5091

GeneCards: human genes, protein and diseases

More...GeneCardsi		PC
GeneReviewsiPC
HGNCiHGNC:8636 PC
HPAiCAB033742
HPA043922
HPA058765
MalaCardsiPC
MIMi266150 phenotype
608786 gene
neXtProtiNX_P11498
OpenTargetsiENSG00000173599
Orphaneti353320 Pyruvate carboxylase deficiency, benign type
353308 Pyruvate carboxylase deficiency, infantile type
353314 Pyruvate carboxylase deficiency, severe neonatal type
PharmGKBiPA32975

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IU5D Eukaryota
COG1038 LUCA
GeneTreeiENSGT00900000141164
HOGENOMiHOG000282801
InParanoidiP11498
KOiK01958
OrthoDBi254436at2759
PhylomeDBiP11498
TreeFamiTF300535

Enzyme and pathway databases

UniPathwayiUPA00138
BioCyciMetaCyc:HS10697-MONOMER
BRENDAi6.4.1.1 2681
ReactomeiR-HSA-196780 Biotin transport and metabolism
R-HSA-3371599 Defective HLCS causes multiple carboxylase deficiency
R-HSA-70263 Gluconeogenesis
SABIO-RKiP11498
SIGNORiP11498

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PC human
EvolutionaryTraceiP11498

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5091
PharosiP11498

Protein Ontology

More...PROi		PR:P11498

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000173599 Expressed in 160 organ(s), highest expression level in right lobe of liver
ExpressionAtlasiP11498 baseline and differential
GenevisibleiP11498 HS

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR011761 ATP-grasp
IPR005481 BC-like_N
IPR001882 Biotin_BS
IPR011764 Biotin_carboxylation_dom
IPR005482 Biotin_COase_C
IPR000089 Biotin_lipoyl
IPR003379 Carboxylase_cons_dom
IPR005479 CbamoylP_synth_lsu-like_ATP-bd
IPR016185 PreATP-grasp_dom_sf
IPR000891 PYR_CT
IPR005930 Pyruv_COase
IPR011054 Rudment_hybrid_motif
IPR011053 Single_hybrid_motif
PfamiView protein in Pfam
PF02785 Biotin_carb_C, 1 hit
PF00289 Biotin_carb_N, 1 hit
PF00364 Biotin_lipoyl, 1 hit
PF02786 CPSase_L_D2, 1 hit
PF00682 HMGL-like, 1 hit
PF02436 PYC_OADA, 1 hit
PIRSFiPIRSF001594 Pyruv_carbox, 1 hit
SMARTiView protein in SMART
SM00878 Biotin_carb_C, 1 hit
SUPFAMiSSF51230 SSF51230, 1 hit
SSF51246 SSF51246, 1 hit
SSF52440 SSF52440, 1 hit
TIGRFAMsiTIGR01235 pyruv_carbox, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS50979 BC, 1 hit
PS00188 BIOTIN, 1 hit
PS50968 BIOTINYL_LIPOYL, 1 hit
PS50991 PYR_CT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPYC_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P11498
Secondary accession number(s): B4DN00, Q16705
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1996
Last modified: October 16, 2019
This is version 218 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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