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Protein

DeltaKappa-actitoxin-Avd4a

Gene
N/A
Organism
Anemonia sulcata (Mediterranean snakelocks sea anemone)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a gating modifier on both Kv and Nav ion channels. Voltage-dependently inhibits voltage-gated potassium channels Kv3 (Kv3.1/KCNC1, Kv3.2/KCNC2 and Kv3.4/KCNC4) and slows inactivation of the voltage-gated sodium channel Nav1.7/SCN9A (PubMed:16177043, PubMed:22442564, PubMed:9506974). Inhibits all Kv3.1, Kv3.2 and Kv3.4 by about 50% when tested at a voltage of +40 mV (45%, 48% and 56%, respectively). May act by binding residues in voltage-sensing domains S3b and S4 of Kv3 (PubMed:16177043). Tests have been done on human Nav1.7/SCN9A (expressed in HEK293 cells) (EC(50)=3 nM) and rat SCG neurons that mostly carry Nav1.7 channels (EC(50)=300 nM) (PubMed:22442564). This toxin also reduces blood pressure (Ref. 1).4 Publications

Miscellaneous

This toxin does not have effect on Nav1.1/SCN1A and Nav1.6/SCN8A sodium channels (PubMed:22442564). It has little or no functional effect on cardiac muscle, as well as on skeletal muscle myotubes, suggesting lack of functional interaction with Nav1.4/SCN4A or Nav1.5/SCN5A (PubMed:9506974).2 Publications

Caution

Opinions are divided on whether Anemonia viridis (Forsskal, 1775) and Anemonia sulcata (Pennant, 1777) are separate species.Curated

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin, Voltage-gated sodium channel impairing toxin

Protein family/group databases

TCDBi8.B.11.1.3 the sea anemone peptide toxin (apetx) family

Names & Taxonomyi

Protein namesi
Recommended name:
DeltaKappa-actitoxin-Avd4a1 Publication
Short name:
DeltaKappa-AITX-Avd4a1 Publication
Alternative name(s):
Antihypertensive protein BDS-1
Blood depressing substance I1 Publication
Short name:
BDS-I1 Publication
OrganismiAnemonia sulcata (Mediterranean snakelocks sea anemone)
Taxonomic identifieri6108 [NCBI]
Taxonomic lineageiEukaryotaMetazoaCnidariaAnthozoaHexacoralliaActiniariaActiniidaeAnemonia

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nematocyst, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002215411 – 43DeltaKappa-actitoxin-Avd4a2 PublicationsAdd BLAST43

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi4 ↔ 391 Publication
Disulfide bondi6 ↔ 321 Publication
Disulfide bondi22 ↔ 401 Publication

Keywords - PTMi

Disulfide bond

Structurei

Secondary structure

143
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP11494
SMRiP11494
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP11494

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di2.20.20.10, 1 hit
InterProiView protein in InterPro
IPR012414 BDS_K_chnl_tox
IPR023355 Myo_ane_neurotoxin_sf
PfamiView protein in Pfam
PF07936 Defensin_4, 1 hit

Sequencei

Sequence statusi: Complete.

P11494-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40 
AAPCFCSGKP GRGDLWILRG TCPGGYGYTS NCYKWPNICC YPH
Length:43
Mass (Da):4,714
Last modified:October 1, 1989 - v1
Checksum:i7C17846E88E2F1D8
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti18L → F. 1

Sequence databases

PIRiA33041

Similar proteinsi

Cross-referencesi

Sequence databases

PIRiA33041

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BDSNMR-A1-43[»]
2BDSNMR-A1-43[»]
ProteinModelPortaliP11494
SMRiP11494
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi8.B.11.1.3 the sea anemone peptide toxin (apetx) family

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP11494

Family and domain databases

Gene3Di2.20.20.10, 1 hit
InterProiView protein in InterPro
IPR012414 BDS_K_chnl_tox
IPR023355 Myo_ane_neurotoxin_sf
PfamiView protein in Pfam
PF07936 Defensin_4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBDS1_ANESU
AccessioniPrimary (citable) accession number: P11494
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: December 20, 2017
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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