Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Fibroblast growth factor 3

Gene

FGF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal ear development.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Growth factor, Mitogen
Biological processDifferentiation

Enzyme and pathway databases

ReactomeiR-HSA-109704 PI3K Cascade
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-190370 FGFR1b ligand binding and activation
R-HSA-190377 FGFR2b ligand binding and activation
R-HSA-2033519 Activated point mutants of FGFR2
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-5654219 Phospholipase C-mediated cascade: FGFR1
R-HSA-5654221 Phospholipase C-mediated cascade, FGFR2
R-HSA-5654687 Downstream signaling of activated FGFR1
R-HSA-5654688 SHC-mediated cascade:FGFR1
R-HSA-5654689 PI-3K cascade:FGFR1
R-HSA-5654693 FRS-mediated FGFR1 signaling
R-HSA-5654695 PI-3K cascade:FGFR2
R-HSA-5654699 SHC-mediated cascade:FGFR2
R-HSA-5654700 FRS-mediated FGFR2 signaling
R-HSA-5654726 Negative regulation of FGFR1 signaling
R-HSA-5654727 Negative regulation of FGFR2 signaling
R-HSA-5655253 Signaling by FGFR2 in disease
R-HSA-5658623 FGFRL1 modulation of FGFR1 signaling
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
SignaLinkiP11487
SIGNORiP11487

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 3
Short name:
FGF-3
Alternative name(s):
Heparin-binding growth factor 3
Short name:
HBGF-3
Proto-oncogene Int-2
Gene namesi
Name:FGF3
Synonyms:INT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000186895.2
HGNCiHGNC:3681 FGF3
MIMi164950 gene
neXtProtiNX_P11487

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Deafness with labyrinthine aplasia, microtia and microdontia (LAMM)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionUnique autosomal recessive syndrome characterized by type I microtia, microdontia, and profound congenital deafness associated with a complete absence of inner ear structures (Michel aplasia).
See also OMIM:610706
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0604926L → P in LAMM; probably impairs secretion. 1 PublicationCorresponds to variant dbSNP:rs121917706EnsemblClinVar.1
Natural variantiVAR_031848156S → P in LAMM. 1 PublicationCorresponds to variant dbSNP:rs121917703EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Proto-oncogene

Organism-specific databases

DisGeNETi2248
GeneReviewsiFGF3
MalaCardsiFGF3
MIMi610706 phenotype
OpenTargetsiENSG00000186895
Orphaneti90024 Deafness with labyrinthine aplasia, microtia, and microdontia
99806 Oculootodental syndrome
2791 Otodental syndrome
PharmGKBiPA28120

Polymorphism and mutation databases

BioMutaiFGF3
DMDMi122748

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000000894618 – 239Fibroblast growth factor 3Add BLAST222

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi65N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP11487
PeptideAtlasiP11487
PRIDEiP11487
ProteomicsDBi52783

PTM databases

iPTMnetiP11487
PhosphoSitePlusiP11487

Expressioni

Gene expression databases

BgeeiENSG00000186895 Expressed in 11 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_FGF3
GenevisibleiP11487 HS

Organism-specific databases

HPAiHPA012692

Interactioni

Subunit structurei

Interacts with FGFR1 and FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108539, 70 interactors
DIPiDIP-4014N
STRINGi9606.ENSP00000334122

Structurei

3D structure databases

ProteinModelPortaliP11487
SMRiP11487
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3885 Eukaryota
ENOG4111IPH LUCA
GeneTreeiENSGT00760000118859
HOGENOMiHOG000236341
HOVERGENiHBG007580
InParanoidiP11487
KOiK04358
OMAiYHLQIHP
OrthoDBiEOG091G0NAY
PhylomeDBiP11487
TreeFamiTF317805

Family and domain databases

CDDicd00058 FGF, 1 hit
InterProiView protein in InterPro
IPR028232 FGF3
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF
PANTHERiPTHR11486 PTHR11486, 1 hit
PTHR11486:SF26 PTHR11486:SF26, 1 hit
PfamiView protein in Pfam
PF00167 FGF, 1 hit
PRINTSiPR00263 HBGFFGF
SMARTiView protein in SMART
SM00442 FGF, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00247 HBGF_FGF, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11487-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLIWLLLLS LLEPGWPAAG PGARLRRDAG GRGGVYEHLG GAPRRRKLYC
60 70 80 90 100
ATKYHLQLHP SGRVNGSLEN SAYSILEITA VEVGIVAIRG LFSGRYLAMN
110 120 130 140 150
KRGRLYASEH YSAECEFVER IHELGYNTYA SRLYRTVSST PGARRQPSAE
160 170 180 190 200
RLWYVSVNGK GRPRRGFKTR RTQKSSLFLP RVLDHRDHEM VRQLQSGLPR
210 220 230
PPGKGVQPRR RRQKQSPDNL EPSHVQASRL GSQLEASAH
Length:239
Mass (Da):26,887
Last modified:October 1, 1989 - v1
Checksum:i8DBEF17D2B2E3C63
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0604926L → P in LAMM; probably impairs secretion. 1 PublicationCorresponds to variant dbSNP:rs121917706EnsemblClinVar.1
Natural variantiVAR_031848156S → P in LAMM. 1 PublicationCorresponds to variant dbSNP:rs121917703EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14445 Genomic DNA Translation: CAA32615.1
BC113739 mRNA Translation: AAI13740.1
CCDSiCCDS8195.1
PIRiS04742
RefSeqiNP_005238.1, NM_005247.2
UniGeneiHs.37092

Genome annotation databases

EnsembliENST00000334134; ENSP00000334122; ENSG00000186895
GeneIDi2248
KEGGihsa:2248
UCSCiuc001oph.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14445 Genomic DNA Translation: CAA32615.1
BC113739 mRNA Translation: AAI13740.1
CCDSiCCDS8195.1
PIRiS04742
RefSeqiNP_005238.1, NM_005247.2
UniGeneiHs.37092

3D structure databases

ProteinModelPortaliP11487
SMRiP11487
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108539, 70 interactors
DIPiDIP-4014N
STRINGi9606.ENSP00000334122

PTM databases

iPTMnetiP11487
PhosphoSitePlusiP11487

Polymorphism and mutation databases

BioMutaiFGF3
DMDMi122748

Proteomic databases

PaxDbiP11487
PeptideAtlasiP11487
PRIDEiP11487
ProteomicsDBi52783

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334134; ENSP00000334122; ENSG00000186895
GeneIDi2248
KEGGihsa:2248
UCSCiuc001oph.4 human

Organism-specific databases

CTDi2248
DisGeNETi2248
EuPathDBiHostDB:ENSG00000186895.2
GeneCardsiFGF3
GeneReviewsiFGF3
HGNCiHGNC:3681 FGF3
HPAiHPA012692
MalaCardsiFGF3
MIMi164950 gene
610706 phenotype
neXtProtiNX_P11487
OpenTargetsiENSG00000186895
Orphaneti90024 Deafness with labyrinthine aplasia, microtia, and microdontia
99806 Oculootodental syndrome
2791 Otodental syndrome
PharmGKBiPA28120
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3885 Eukaryota
ENOG4111IPH LUCA
GeneTreeiENSGT00760000118859
HOGENOMiHOG000236341
HOVERGENiHBG007580
InParanoidiP11487
KOiK04358
OMAiYHLQIHP
OrthoDBiEOG091G0NAY
PhylomeDBiP11487
TreeFamiTF317805

Enzyme and pathway databases

ReactomeiR-HSA-109704 PI3K Cascade
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-190370 FGFR1b ligand binding and activation
R-HSA-190377 FGFR2b ligand binding and activation
R-HSA-2033519 Activated point mutants of FGFR2
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-5654219 Phospholipase C-mediated cascade: FGFR1
R-HSA-5654221 Phospholipase C-mediated cascade, FGFR2
R-HSA-5654687 Downstream signaling of activated FGFR1
R-HSA-5654688 SHC-mediated cascade:FGFR1
R-HSA-5654689 PI-3K cascade:FGFR1
R-HSA-5654693 FRS-mediated FGFR1 signaling
R-HSA-5654695 PI-3K cascade:FGFR2
R-HSA-5654699 SHC-mediated cascade:FGFR2
R-HSA-5654700 FRS-mediated FGFR2 signaling
R-HSA-5654726 Negative regulation of FGFR1 signaling
R-HSA-5654727 Negative regulation of FGFR2 signaling
R-HSA-5655253 Signaling by FGFR2 in disease
R-HSA-5658623 FGFRL1 modulation of FGFR1 signaling
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
SignaLinkiP11487
SIGNORiP11487

Miscellaneous databases

ChiTaRSiFGF3 human
GeneWikiiFGF3
GenomeRNAii2248
PROiPR:P11487
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000186895 Expressed in 11 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_FGF3
GenevisibleiP11487 HS

Family and domain databases

CDDicd00058 FGF, 1 hit
InterProiView protein in InterPro
IPR028232 FGF3
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF
PANTHERiPTHR11486 PTHR11486, 1 hit
PTHR11486:SF26 PTHR11486:SF26, 1 hit
PfamiView protein in Pfam
PF00167 FGF, 1 hit
PRINTSiPR00263 HBGFFGF
SMARTiView protein in SMART
SM00442 FGF, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00247 HBGF_FGF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFGF3_HUMAN
AccessioniPrimary (citable) accession number: P11487
Secondary accession number(s): Q0VG69
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: September 12, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again