FGF3

Functionⁱ

Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal ear development.1 Publication

GO - Molecular functionⁱ

1-phosphatidylinositol-3-kinase activity Source: Reactome
fibroblast growth factor receptor binding Source: InterPro
growth factor activity
Source: ProtInc
Traceable author statementⁱ
- 2470007
phosphatidylinositol-4,5-bisphosphate 3-kinase activity Source: Reactome
protein tyrosine kinase activity Source: Reactome
Ras guanyl-nucleotide exchange factor activity Source: Reactome

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

anatomical structure morphogenesis
Source: ProtInc
Traceable author statementⁱ
- 2470007
cell-cell signaling
Source: ProtInc
Traceable author statementⁱ
- 2470007
cell differentiation Source: UniProtKB-KW
fibroblast growth factor receptor signaling pathway
Source: MGI
Inferred from genetic interactionⁱ
- 8663044
MAPK cascade Source: Reactome
multicellular organism development Source: UniProtKB-KW
negative regulation of cardiac muscle tissue development
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 20702560
positive regulation of cell division Source: UniProtKB-KW
positive regulation of cell proliferation
Source: MGI
Inferred from genetic interactionⁱ
- 8663044
positive regulation of protein kinase B signaling Source: Reactome
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 2470007

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, Growth factor, Mitogen
Biological process	Differentiation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-109704 PI3K Cascade R-HSA-1257604 PIP3 activates AKT signaling R-HSA-190370 FGFR1b ligand binding and activation R-HSA-190377 FGFR2b ligand binding and activation R-HSA-2033519 Activated point mutants of FGFR2 R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-5654219 Phospholipase C-mediated cascade: FGFR1 R-HSA-5654221 Phospholipase C-mediated cascade, FGFR2 R-HSA-5654687 Downstream signaling of activated FGFR1 R-HSA-5654688 SHC-mediated cascade:FGFR1 R-HSA-5654689 PI-3K cascade:FGFR1 R-HSA-5654693 FRS-mediated FGFR1 signaling R-HSA-5654695 PI-3K cascade:FGFR2 R-HSA-5654699 SHC-mediated cascade:FGFR2 R-HSA-5654700 FRS-mediated FGFR2 signaling R-HSA-5654726 Negative regulation of FGFR1 signaling R-HSA-5654727 Negative regulation of FGFR2 signaling R-HSA-5655253 Signaling by FGFR2 in disease R-HSA-5658623 FGFRL1 modulation of FGFR1 signaling R-HSA-5673001 RAF/MAP kinase cascade R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
SignaLinkⁱ	P11487
SIGNORⁱ	P11487

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Fibroblast growth factor 3 Short name: FGF-3 Alternative name(s): Heparin-binding growth factor 3 Short name: HBGF-3 Proto-oncogene Int-2
Gene namesⁱ	Name:FGF3 Synonyms:INT2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000186895.2
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3681 FGF3
MIMⁱ	164950 gene
neXtProtⁱ	NX_P11487

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Deafness with labyrinthine aplasia, microtia and microdontia (LAMM)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionUnique autosomal recessive syndrome characterized by type I microtia, microdontia, and profound congenital deafness associated with a complete absence of inner ear structures (Michel aplasia).

Keywords - Diseaseⁱ

Disease mutation, Proto-oncogene

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2248
GeneReviewsⁱ	FGF3
MalaCards human disease database More...MalaCardsⁱ	FGF3
MIMⁱ	610706 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000186895
Orphanetⁱ	90024 Deafness with labyrinthine aplasia, microtia, and microdontia 99806 Oculootodental syndrome 2791 Otodental syndrome
PharmGKBⁱ	PA28120

Polymorphism and mutation databases

BioMutaⁱ	FGF3
DMDMⁱ	122748

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 17	Sequence analysisAdd BLAST		17
ChainⁱPRO_0000008946	18 – 239	Fibroblast growth factor 3Add BLAST		222

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	65	N-linked (GlcNAc...) asparagineSequence analysis		1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

PaxDbⁱ	P11487
PeptideAtlas More...PeptideAtlasⁱ	P11487
PRIDEⁱ	P11487
ProteomicsDBⁱ	52783

PTM databases

iPTMnetⁱ	P11487
PhosphoSitePlusⁱ	P11487

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000186895 Expressed in 11 organ(s), highest expression level in right hemisphere of cerebellum
CleanExⁱ	HS_FGF3
Genevisibleⁱ	P11487 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA012692

HPAⁱ

HPA012692

Interactionⁱ

Subunit structureⁱ

Interacts with FGFR1 and FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.1 Publication

GO - Molecular functionⁱ

fibroblast growth factor receptor binding Source: InterPro
growth factor activity
Source: ProtInc
Traceable author statementⁱ
- 2470007
Ras guanyl-nucleotide exchange factor activity Source: Reactome

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	108539, 70 interactors
Database of interacting proteins More...DIPⁱ	DIP-4014N
STRINGⁱ	9606.ENSP00000334122

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P11487
SMRⁱ	P11487
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the heparin-binding growth factors family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG3885 Eukaryota ENOG4111IPH LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118859
HOGENOMⁱ	HOG000236341
HOVERGENⁱ	HBG007580
InParanoidⁱ	P11487
KEGG Orthology (KO) More...KOⁱ	K04358
OMAⁱ	YHLQIHP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0NAY
PhylomeDBⁱ	P11487
TreeFamⁱ	TF317805

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00058 FGF, 1 hit
InterProⁱ	View protein in InterPro IPR028232 FGF3 IPR002209 Fibroblast_GF_fam IPR008996 IL1/FGF
PANTHERⁱ	PTHR11486 PTHR11486, 1 hit PTHR11486:SF26 PTHR11486:SF26, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00167 FGF, 1 hit
PRINTSⁱ	PR00263 HBGFFGF
SMARTⁱ	View protein in SMART SM00442 FGF, 1 hit
SUPFAMⁱ	SSF50353 SSF50353, 1 hit
PROSITEⁱ	View protein in PROSITE PS00247 HBGF_FGF, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P11487-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGLIWLLLLS LLEPGWPAAG PGARLRRDAG GRGGVYEHLG GAPRRRKLYC 
        60         70         80         90        100
ATKYHLQLHP SGRVNGSLEN SAYSILEITA VEVGIVAIRG LFSGRYLAMN 
       110        120        130        140        150
KRGRLYASEH YSAECEFVER IHELGYNTYA SRLYRTVSST PGARRQPSAE 
       160        170        180        190        200
RLWYVSVNGK GRPRRGFKTR RTQKSSLFLP RVLDHRDHEM VRQLQSGLPR 
       210        220        230 
PPGKGVQPRR RRQKQSPDNL EPSHVQASRL GSQLEASAH

Length:239

Mass (Da):26,887

Last modified:October 1, 1989 - v1

Checksum:ⁱ8DBEF17D2B2E3C63

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_060492	6	L → P in LAMM; probably impairs secretion. 1 PublicationCorresponds to variant dbSNP:rs121917706EnsemblClinVar.		1
Natural variantⁱVAR_031848	156	S → P in LAMM. 1 PublicationCorresponds to variant dbSNP:rs121917703EnsemblClinVar.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X14445 Genomic DNA Translation: CAA32615.1 BC113739 mRNA Translation: AAI13740.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8195.1
PIRⁱ	S04742
NCBI Reference Sequences More...RefSeqⁱ	NP_005238.1, NM_005247.2
UniGeneⁱ	Hs.37092

Genome annotation databases

Ensemblⁱ	ENST00000334134; ENSP00000334122; ENSG00000186895
GeneIDⁱ	2248
KEGGⁱ	hsa:2248
UCSC genome browser More...UCSCⁱ	uc001oph.4 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P11487	Fibroblast growth factor		PANTR		239	UniRef90_P11487
Fibroblast growth factor		PONAB		239
Fibroblast growth factor		CALJA		239
Fibroblast growth factor		Cebus capucinus imitator		239
Fibroblast growth factor		CERAT		239
+15

Protein	Similar proteins		Species	Score	Length	Source
P11487	Fibroblast growth factor 3		DANRE		256	UniRef50_P48802
Fibroblast growth factor 3		XENLA		237
Fibroblast growth factor		CYPCA		256
Fibroblast growth factor		ORYLA		241
Fibroblast growth factor		Asian bonytongue		249
+145

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X14445 Genomic DNA Translation: CAA32615.1 BC113739 mRNA Translation: AAI13740.1
CCDSⁱ	CCDS8195.1
PIRⁱ	S04742
RefSeqⁱ	NP_005238.1, NM_005247.2
UniGeneⁱ	Hs.37092

3D structure databases

ProteinModelPortalⁱ	P11487
SMRⁱ	P11487
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108539, 70 interactors
DIPⁱ	DIP-4014N
STRINGⁱ	9606.ENSP00000334122

PTM databases

iPTMnetⁱ	P11487
PhosphoSitePlusⁱ	P11487

Polymorphism and mutation databases

BioMutaⁱ	FGF3
DMDMⁱ	122748

Proteomic databases

PaxDbⁱ	P11487
PeptideAtlasⁱ	P11487
PRIDEⁱ	P11487
ProteomicsDBⁱ	52783

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000334134; ENSP00000334122; ENSG00000186895
GeneIDⁱ	2248
KEGGⁱ	hsa:2248
UCSCⁱ	uc001oph.4 human

Organism-specific databases

CTDⁱ	2248
DisGeNETⁱ	2248
EuPathDBⁱ	HostDB:ENSG00000186895.2
GeneCardsⁱ	FGF3
GeneReviewsⁱ	FGF3
HGNCⁱ	HGNC:3681 FGF3
HPAⁱ	HPA012692
MalaCardsⁱ	FGF3
MIMⁱ	164950 gene 610706 phenotype
neXtProtⁱ	NX_P11487
OpenTargetsⁱ	ENSG00000186895
Orphanetⁱ	90024 Deafness with labyrinthine aplasia, microtia, and microdontia 99806 Oculootodental syndrome 2791 Otodental syndrome
PharmGKBⁱ	PA28120
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3885 Eukaryota ENOG4111IPH LUCA
GeneTreeⁱ	ENSGT00760000118859
HOGENOMⁱ	HOG000236341
HOVERGENⁱ	HBG007580
InParanoidⁱ	P11487
KOⁱ	K04358
OMAⁱ	YHLQIHP
OrthoDBⁱ	EOG091G0NAY
PhylomeDBⁱ	P11487
TreeFamⁱ	TF317805

Enzyme and pathway databases

Reactomeⁱ	R-HSA-109704 PI3K Cascade R-HSA-1257604 PIP3 activates AKT signaling R-HSA-190370 FGFR1b ligand binding and activation R-HSA-190377 FGFR2b ligand binding and activation R-HSA-2033519 Activated point mutants of FGFR2 R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-5654219 Phospholipase C-mediated cascade: FGFR1 R-HSA-5654221 Phospholipase C-mediated cascade, FGFR2 R-HSA-5654687 Downstream signaling of activated FGFR1 R-HSA-5654688 SHC-mediated cascade:FGFR1 R-HSA-5654689 PI-3K cascade:FGFR1 R-HSA-5654693 FRS-mediated FGFR1 signaling R-HSA-5654695 PI-3K cascade:FGFR2 R-HSA-5654699 SHC-mediated cascade:FGFR2 R-HSA-5654700 FRS-mediated FGFR2 signaling R-HSA-5654726 Negative regulation of FGFR1 signaling R-HSA-5654727 Negative regulation of FGFR2 signaling R-HSA-5655253 Signaling by FGFR2 in disease R-HSA-5658623 FGFRL1 modulation of FGFR1 signaling R-HSA-5673001 RAF/MAP kinase cascade R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
SignaLinkⁱ	P11487
SIGNORⁱ	P11487

Miscellaneous databases

ChiTaRSⁱ	FGF3 human
GeneWikiⁱ	FGF3
GenomeRNAiⁱ	2248
Protein Ontology More...PROⁱ	PR:P11487
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000186895 Expressed in 11 organ(s), highest expression level in right hemisphere of cerebellum
CleanExⁱ	HS_FGF3
Genevisibleⁱ	P11487 HS

Family and domain databases

CDDⁱ	cd00058 FGF, 1 hit
InterProⁱ	View protein in InterPro IPR028232 FGF3 IPR002209 Fibroblast_GF_fam IPR008996 IL1/FGF
PANTHERⁱ	PTHR11486 PTHR11486, 1 hit PTHR11486:SF26 PTHR11486:SF26, 1 hit
Pfamⁱ	View protein in Pfam PF00167 FGF, 1 hit
PRINTSⁱ	PR00263 HBGFFGF
SMARTⁱ	View protein in SMART SM00442 FGF, 1 hit
SUPFAMⁱ	SSF50353 SSF50353, 1 hit
PROSITEⁱ	View protein in PROSITE PS00247 HBGF_FGF, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FGF3_HUMAN
Accessionⁱ	P11487Primary (citable) accession number: P11487 Secondary accession number(s): Q0VG69
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
	Last sequence update:	October 1, 1989
	Last modified:	September 12, 2018
	This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM

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UniRef

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Supporting data

UniProtKB - P11487 (FGF3_HUMAN)

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Fibroblast growth factor 3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ