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UniProtKB - P11487 (FGF3_HUMAN)

Entry version 176 (25 May 2022)
Sequence version 1 (01 Oct 1989)
Previous versions | rss
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Protein

Fibroblast growth factor 3

Gene

FGF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal ear development.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Growth factor, Mitogen
Biological processDifferentiation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P11487

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-109704, PI3K Cascade
R-HSA-1257604, PIP3 activates AKT signaling
R-HSA-190370, FGFR1b ligand binding and activation
R-HSA-190377, FGFR2b ligand binding and activation
R-HSA-2033519, Activated point mutants of FGFR2
R-HSA-2219530, Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-5654219, Phospholipase C-mediated cascade: FGFR1
R-HSA-5654221, Phospholipase C-mediated cascade, FGFR2
R-HSA-5654687, Downstream signaling of activated FGFR1
R-HSA-5654688, SHC-mediated cascade:FGFR1
R-HSA-5654689, PI-3K cascade:FGFR1
R-HSA-5654693, FRS-mediated FGFR1 signaling
R-HSA-5654695, PI-3K cascade:FGFR2
R-HSA-5654699, SHC-mediated cascade:FGFR2
R-HSA-5654700, FRS-mediated FGFR2 signaling
R-HSA-5654726, Negative regulation of FGFR1 signaling
R-HSA-5654727, Negative regulation of FGFR2 signaling
R-HSA-5655253, Signaling by FGFR2 in disease
R-HSA-5658623, FGFRL1 modulation of FGFR1 signaling
R-HSA-5673001, RAF/MAP kinase cascade
R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P11487

SIGNOR Signaling Network Open Resource

More...SIGNORi		P11487

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fibroblast growth factor 3
Short name:
FGF-3
Alternative name(s):
Heparin-binding growth factor 3
Short name:
HBGF-3
Proto-oncogene Int-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FGF3
Synonyms:INT2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:3681, FGF3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		164950, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P11487

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000186895

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Deafness with labyrinthine aplasia, microtia and microdontia (LAMM)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionUnique autosomal recessive syndrome characterized by type I microtia, microdontia, and profound congenital deafness associated with a complete absence of inner ear structures (Michel aplasia).
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0604926L → P in LAMM; probably impairs secretion. 1 PublicationCorresponds to variant dbSNP:rs121917706EnsemblClinVar.1
Natural variantiVAR_031848156S → P in LAMM. 1 PublicationCorresponds to variant dbSNP:rs121917703EnsemblClinVar.1

Keywords - Diseasei

Disease variant, Proto-oncogene

Organism-specific databases

DisGeNET

More...DisGeNETi		2248

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		FGF3

MalaCards human disease database

More...MalaCardsi		FGF3
MIMi610706, phenotype

Open Targets

More...OpenTargetsi		ENSG00000186895

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		90024, Deafness with labyrinthine aplasia, microtia, and microdontia
99806, Oculootodental syndrome
2791, Otodental syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA28120

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P11487, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		FGF3

Domain mapping of disease mutations (DMDM)

More...DMDMi		122748

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 17Sequence analysisAdd BLAST17
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000894618 – 239Fibroblast growth factor 3Add BLAST222

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi65N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P11487

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P11487

PeptideAtlas

More...PeptideAtlasi		P11487

PRoteomics IDEntifications database

More...PRIDEi		P11487

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		52783

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P11487, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P11487

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P11487

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000186895, Expressed in right hemisphere of cerebellum and 17 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P11487, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000186895, Tissue enriched (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with FGFR1 and FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.

1 Publication

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		108539, 64 interactors

Database of interacting proteins

More...DIPi		DIP-4014N

Protein interaction database and analysis system

More...IntActi		P11487, 52 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000334122

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P11487, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P11487

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P11487

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni193 – 239DisorderedSequence analysisAdd BLAST47

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi219 – 239Polar residuesSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the heparin-binding growth factors family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3885, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161128

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_081609_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P11487

Identification of Orthologs from Complete Genome Data

More...OMAi		TLLQEPW

Database of Orthologous Groups

More...OrthoDBi		1157770at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P11487

TreeFam database of animal gene trees

More...TreeFami		TF317805

Family and domain databases

Conserved Domains Database

More...CDDi		cd00058, FGF, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR028232, FGF3
IPR002209, Fibroblast_GF_fam
IPR008996, IL1/FGF

The PANTHER Classification System

More...PANTHERi		PTHR11486, PTHR11486, 1 hit
PTHR11486:SF26, PTHR11486:SF26, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00167, FGF, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00263, HBGFFGF

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00442, FGF, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50353, SSF50353, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00247, HBGF_FGF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P11487-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLIWLLLLS LLEPGWPAAG PGARLRRDAG GRGGVYEHLG GAPRRRKLYC 
        60         70         80         90        100
ATKYHLQLHP SGRVNGSLEN SAYSILEITA VEVGIVAIRG LFSGRYLAMN 
       110        120        130        140        150
KRGRLYASEH YSAECEFVER IHELGYNTYA SRLYRTVSST PGARRQPSAE 
       160        170        180        190        200
RLWYVSVNGK GRPRRGFKTR RTQKSSLFLP RVLDHRDHEM VRQLQSGLPR 
       210        220        230 
PPGKGVQPRR RRQKQSPDNL EPSHVQASRL GSQLEASAH
Length:239
Mass (Da):26,887
Last modified:October 1, 1989 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8DBEF17D2B2E3C63
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0604926L → P in LAMM; probably impairs secretion. 1 PublicationCorresponds to variant dbSNP:rs121917706EnsemblClinVar.1
Natural variantiVAR_031848156S → P in LAMM. 1 PublicationCorresponds to variant dbSNP:rs121917703EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X14445 Genomic DNA Translation: CAA32615.1
BC113739 mRNA Translation: AAI13740.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS8195.1

Protein sequence database of the Protein Information Resource

More...PIRi		S04742

NCBI Reference Sequences

More...RefSeqi		NP_005238.1, NM_005247.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000334134.4; ENSP00000334122.2; ENSG00000186895.4

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2248

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:2248

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000334134.4; ENSP00000334122.2; NM_005247.4; NP_005238.1

UCSC genome browser

More...UCSCi		uc001oph.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14445 Genomic DNA Translation: CAA32615.1
BC113739 mRNA Translation: AAI13740.1
CCDSiCCDS8195.1
PIRiS04742
RefSeqiNP_005238.1, NM_005247.2

3D structure databases

AlphaFoldDBiP11487
SMRiP11487
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi108539, 64 interactors
DIPiDIP-4014N
IntActiP11487, 52 interactors
STRINGi9606.ENSP00000334122

PTM databases

GlyGeniP11487, 1 site
iPTMnetiP11487
PhosphoSitePlusiP11487

Genetic variation databases

BioMutaiFGF3
DMDMi122748

Proteomic databases

MassIVEiP11487
PaxDbiP11487
PeptideAtlasiP11487
PRIDEiP11487
ProteomicsDBi52783

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2164, 218 antibodies from 27 providers

The DNASU plasmid repository

More...DNASUi		2248

Genome annotation databases

EnsembliENST00000334134.4; ENSP00000334122.2; ENSG00000186895.4
GeneIDi2248
KEGGihsa:2248
MANE-SelectiENST00000334134.4; ENSP00000334122.2; NM_005247.4; NP_005238.1
UCSCiuc001oph.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2248
DisGeNETi2248

GeneCards: human genes, protein and diseases

More...GeneCardsi		FGF3
GeneReviewsiFGF3
HGNCiHGNC:3681, FGF3
HPAiENSG00000186895, Tissue enriched (brain)
MalaCardsiFGF3
MIMi164950, gene
610706, phenotype
neXtProtiNX_P11487
OpenTargetsiENSG00000186895
Orphaneti90024, Deafness with labyrinthine aplasia, microtia, and microdontia
99806, Oculootodental syndrome
2791, Otodental syndrome
PharmGKBiPA28120
VEuPathDBiHostDB:ENSG00000186895

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3885, Eukaryota
GeneTreeiENSGT00940000161128
HOGENOMiCLU_081609_1_0_1
InParanoidiP11487
OMAiTLLQEPW
OrthoDBi1157770at2759
PhylomeDBiP11487
TreeFamiTF317805

Enzyme and pathway databases

PathwayCommonsiP11487
ReactomeiR-HSA-109704, PI3K Cascade
R-HSA-1257604, PIP3 activates AKT signaling
R-HSA-190370, FGFR1b ligand binding and activation
R-HSA-190377, FGFR2b ligand binding and activation
R-HSA-2033519, Activated point mutants of FGFR2
R-HSA-2219530, Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-5654219, Phospholipase C-mediated cascade: FGFR1
R-HSA-5654221, Phospholipase C-mediated cascade, FGFR2
R-HSA-5654687, Downstream signaling of activated FGFR1
R-HSA-5654688, SHC-mediated cascade:FGFR1
R-HSA-5654689, PI-3K cascade:FGFR1
R-HSA-5654693, FRS-mediated FGFR1 signaling
R-HSA-5654695, PI-3K cascade:FGFR2
R-HSA-5654699, SHC-mediated cascade:FGFR2
R-HSA-5654700, FRS-mediated FGFR2 signaling
R-HSA-5654726, Negative regulation of FGFR1 signaling
R-HSA-5654727, Negative regulation of FGFR2 signaling
R-HSA-5655253, Signaling by FGFR2 in disease
R-HSA-5658623, FGFRL1 modulation of FGFR1 signaling
R-HSA-5673001, RAF/MAP kinase cascade
R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
SignaLinkiP11487
SIGNORiP11487

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		2248, 8 hits in 1062 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		FGF3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		2248
PharosiP11487, Tbio

Protein Ontology

More...PROi		PR:P11487
RNActiP11487, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000186895, Expressed in right hemisphere of cerebellum and 17 other tissues
GenevisibleiP11487, HS

Family and domain databases

CDDicd00058, FGF, 1 hit
InterProiView protein in InterPro
IPR028232, FGF3
IPR002209, Fibroblast_GF_fam
IPR008996, IL1/FGF
PANTHERiPTHR11486, PTHR11486, 1 hit
PTHR11486:SF26, PTHR11486:SF26, 1 hit
PfamiView protein in Pfam
PF00167, FGF, 1 hit
PRINTSiPR00263, HBGFFGF
SMARTiView protein in SMART
SM00442, FGF, 1 hit
SUPFAMiSSF50353, SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00247, HBGF_FGF, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFGF3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P11487
Secondary accession number(s): Q0VG69
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: May 25, 2022
This is version 176 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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