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Protein

Alpha-defensin 1

Gene

Defa1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably contributes to the antimicrobial barrier function of the small bowel mucosa. Has antibacterial activity against attenuated mutants of S.typhimurium.

GO - Biological processi

  • cellular response to lipopolysaccharide Source: MGI
  • defense response to bacterium Source: MGI
  • defense response to Gram-negative bacterium Source: MGI
  • defense response to Gram-positive bacterium Source: MGI
  • response to drug Source: MGI

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Defensin

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-defensin 1
Alternative name(s):
Cryptdin-1
Defensin-related cryptdin peptide
Gene namesi
Name:Defa1
Synonyms:Defcr, Defcr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:94880 Defa1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000000681720 – 58Sequence analysisAdd BLAST39
PeptideiPRO_000000681859 – 93Alpha-defensin 1Add BLAST35

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi64 ↔ 92By similarity
Disulfide bondi66 ↔ 81By similarity
Disulfide bondi71 ↔ 91By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PeptideAtlasiP11477
PRIDEiP11477

PTM databases

PhosphoSitePlusiP11477

Expressioni

Tissue specificityi

Paneth cells of the small bowel.

Developmental stagei

Accumulates to high levels in mouse intestinal crypt epithelium during postnatal development.

Gene expression databases

CleanExiMM_DEFA1

Structurei

3D structure databases

ProteinModelPortaliP11477
SMRiP11477
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000233351
HOVERGENiHBG011703
InParanoidiP11477
KOiK05230
PhylomeDBiP11477

Family and domain databases

InterProiView protein in InterPro
IPR006081 Alpha-defensin
IPR016327 Alpha-defensin_pro
IPR006080 Defensin_beta/alpha
IPR002366 Defensin_propep
PANTHERiPTHR11876 PTHR11876, 1 hit
PfamiView protein in Pfam
PF00323 Defensin_1, 1 hit
PF00879 Defensin_propep, 1 hit
PIRSFiPIRSF001875 Alpha-defensin, 1 hit
SMARTiView protein in SMART
SM00048 DEFSN, 1 hit
PROSITEiView protein in PROSITE
PS00269 DEFENSIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11477-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKLVLLFAL VLLGFQVQAD SIQNTDEETK TEEQPGEEDQ AVSVSFGDPE
60 70 80 90
GTSLQEESLR DLVCYCRSRG CKGRERMNGT CRKGHLLYTL CCR
Length:93
Mass (Da):10,461
Last modified:August 1, 1990 - v2
Checksum:i3CD0B6FB9644A22D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3K → T in AAB60675 (PubMed:8188287).Curated1
Sequence conflicti8F → S in AAB60675 (PubMed:8188287).Curated1
Sequence conflicti14G → A in AAB60675 (PubMed:8188287).Curated1
Sequence conflicti21S → P in AAB60675 (PubMed:8188287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33225 mRNA Translation: AAA63296.1
U02995, U02994 Genomic DNA Translation: AAB60675.1
X15617 mRNA Translation: CAA33636.1
PIRiA36438 A43279
RefSeqiNP_034161.2, NM_010031.2
UniGeneiMm.425522

Genome annotation databases

GeneIDi13216
KEGGimmu:13216

Similar proteinsi

Entry informationi

Entry nameiDEFA1_MOUSE
AccessioniPrimary (citable) accession number: P11477
Secondary accession number(s): Q61448
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: August 1, 1990
Last modified: May 10, 2017
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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