ESRRA

Functionⁱ

Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle.6 Publications

Manual assertion based on experiment inⁱ

Ref.5
"The orphan nuclear receptor estrogen-related receptor alpha is a transcriptional regulator of the human medium-chain acyl coenzyme A dehydrogenase gene."
Sladek R., Bader J.-A., Giguere V.
Mol. Cell. Biol. 17:5400-5409(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
Ref.6
"The transcriptional coactivator PGC-1 regulates the expression and activity of the orphan nuclear receptor estrogen-related receptor alpha (ERRalpha)."
Schreiber S.N., Knutti D., Brogli K., Uhlmann T., Kralli A.
J. Biol. Chem. 278:9013-9018(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH PPARGC1A, INDUCTION, FUNCTION.
Ref.7
"A single nucleotide in an estrogen-related receptor alpha site can dictate mode of binding and peroxisome proliferator-activated receptor gamma coactivator 1alpha activation of target promoters."
Barry J.B., Laganiere J., Giguere V.
Mol. Endocrinol. 20:302-310(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: DNA-BINDING SPECIFICITY, INTERACTION WITH PPARGC1A, HOMODIMERIZATION, FUNCTION, MUTAGENESIS OF SER-118 AND THR-124.
Ref.8
"Phosphorylation-dependent sumoylation of estrogen-related receptor alpha1."
Vu E.H., Kraus R.J., Mertz J.E.
Biochemistry 46:9795-9804(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: SUMOYLATION AT LYS-14 AND LYS-403, PHOSPHORYLATION AT SER-19 AND SER-22, FUNCTION, MUTAGENESIS OF LYS-14; SER-19; SER-22; LYS-403; LEU-413 AND LEU-418.
Ref.9
"Phosphorylation-dependent sumoylation regulates estrogen-related receptor-alpha and -gamma transcriptional activity through a synergy control motif."
Tremblay A.M., Wilson B.J., Yang X.-J., Giguere V.
Mol. Endocrinol. 22:570-584(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: SUMOYLATION AT LYS-14 AND LYS-403, PHOSPHORYLATION AT SER-19 AND SER-22, INTERACTION WITH PIAS4, FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF LYS-14; SER-19; SER-22 AND LYS-403.
Ref.13
"Peroxisome proliferator-activated receptor gamma coactivator 1 (PGC-1)- and estrogen-related receptor (ERR)-induced regulator in muscle 1 (Perm1) is a tissue-specific regulator of oxidative capacity in skeletal muscle cells."
Cho Y., Hazen B.C., Russell A.P., Kralli A.
J. Biol. Chem. 288:25207-25218(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	124	Required for DNA-dependent dimerization		1

Regions

Feature key	Position(s)	DescriptionActions	Length
DNA bindingⁱ	76 – 151	Nuclear receptorPROSITE-ProRule annotationAdd BLAST	76
Zinc fingerⁱ	79 – 99	NR C4-typePROSITE-ProRule annotationAdd BLAST	21
Zinc fingerⁱ	115 – 134	NR C4-typePROSITE-ProRule annotationAdd BLAST	20

GO - Molecular functionⁱ

DNA binding
Source: ProtInc
Traceable author statementⁱ
- 9286700
DNA-binding transcription factor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 21190936
nuclear receptor activity
Source: ProtInc
Traceable author statementⁱ
- 9286700
protein domain specific binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 11984006
RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
sequence-specific DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 23836911
steroid binding Source: InterPro
steroid hormone receptor activity Source: InterPro
transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl
transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cartilage development Source: Ensembl
mitochondrion organization Source: Reactome
positive regulation of cellular response to insulin stimulus Source: Ensembl
positive regulation of transcription by RNA polymerase II Source: BHF-UCL
regulation of cell proliferation Source: Ensembl
regulation of osteoblast differentiation Source: Ensembl
regulation of osteoclast differentiation Source: Ensembl
regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23836911
response to estradiol Source: Ensembl
transcription initiation from RNA polymerase II promoter Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, Receptor
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1989781 PPARA activates gene expression R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis R-HSA-383280 Nuclear Receptor transcription pathway R-HSA-8939902 Regulation of RUNX2 expression and activity
SignaLinkⁱ	P11474
SIGNORⁱ	P11474

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Steroid hormone receptor ERR1 Alternative name(s): Estrogen receptor-like 1 Estrogen-related receptor alpha Short name: ERR-alpha Nuclear receptor subfamily 3 group B member 1
Gene namesⁱ	Name:ESRRA Synonyms:ERR1, ESRL1, NR3B1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000173153.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3471 ESRRA
MIMⁱ	601998 gene
neXtProtⁱ	NX_P11474

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	14	K → R: Some loss of sumoylation. Complete loss of sumoylation; when associated with R-403. 2 Publications	1
Mutagenesisⁱ	19	S → A: 50% loss of phosphorylation but represses transactivation activity in the absence of coactivator. Almost complete loss of phosphorylation and 2-fold loss of repression of transactivation activity in response to coactivator; when associated with A-22. 2 Publications	1
Mutagenesisⁱ	19	S → D: Represses transactivation activity in response to coactivator as for wild type; when associated with D-22. 2 Publications	1
Mutagenesisⁱ	22	S → A: 15% loss of phosphorylation but little transactivating activity. Almost complete loss of phosphorylation and 2-fold loss of repression of transactivation activity in the presence of coactivator; when associated with A-19. 2 Publications	1
Mutagenesisⁱ	22	S → D: Represses transactivation activity in response to coactivator as for wild type; when associated with D-19. 2 Publications	1
Mutagenesisⁱ	118	S → A: Binds DNA as a monomer or as a dimer as for wild type. No effect on interaction with PPARGC1A. 1 Publication	1
Mutagenesisⁱ	124	T → A: Binds DNA predominantly as a monomer. Loss of interaction with PPARGC1A. 1 Publication	1
Mutagenesisⁱ	129	K → R: Abolishes acetylation by PCAF/KAT2B; when associated with R-138, R-160 and R-162. 1 Publication	1
Mutagenesisⁱ	138	K → R: Abolishes acetylation by PCAF/KAT2B; when associated with R-129, R-160 and R-162. 1 Publication	1
Mutagenesisⁱ	160	K → R: Abolishes acetylation by PCAF/KAT2B; when associated with R-129, R-138 and R-162. 1 Publication	1
Mutagenesisⁱ	162	K → R: Abolishes acetylation by PCAF/KAT2B; when associated with R-129, R-138 and R-160. 1 Publication	1
Mutagenesisⁱ	258 – 262	MSVLQ → VSVLE: Almost complete loss of interaction to L2 or to L3 of PPARGC1A. 1 Publication	5
Mutagenesisⁱ	259	S → H: Little effect on binding L2 of PPARGC1A. Greatly reduced binding to L3 of PPARGC1A. 1 Publication	1
Mutagenesisⁱ	315	R → A: Almost complete loss of interaction to L2 or to L3 of PPARGC1A. 1 Publication	1
Mutagenesisⁱ	338	D → A: Almost complete loss of interaction to L2 or to L3 of PPARGC1A. 1 Publication	1
Mutagenesisⁱ	341	H → A: Little effect on binding L3 of PPARGC1A. 1 Publication	1
Mutagenesisⁱ	343	E → A: No effect on binding L3 of PPARGC1A. 1 Publication	1
Mutagenesisⁱ	403	K → R: Decrease in sumoylation. No effect on transcriptional activity. Complete loss of sumoylation; when associated with R-14. 2 Publications	1
Mutagenesisⁱ	413	L → A: Loss of coactivation activity; when associated with A-418. Loss of increased response to coactivator; when associated with A-19 and A-418. 1 Publication	1
Mutagenesisⁱ	418	L → A: Loss of coactivation activity; when associated with A-413. Loss of increased response to coactivator activity; when associated with A-19 and A-413. 1 Publication	1
Mutagenesisⁱ	421 – 423	Missing : Greatly reduced interaction with L3 motif of PPARGC1A. Less effect on binding to L2 motif of PPARGC1A. 1 Publication	3
Mutagenesisⁱ	423	D → A: Little effect on binding L3 of PPARGC1A.	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2101
Open Targets More...OpenTargetsⁱ	ENSG00000173153
PharmGKBⁱ	PA27887

Chemistry databases

ChEMBLⁱ	CHEMBL3429
Drug and drug target database More...DrugBankⁱ	DB06833 1-CYCLOHEXYL-N-{[1-(4-METHYLPHENYL)-1H-INDOL-3-YL]METHYL}METHANAMINE DB00197 Troglitazone
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	622

Polymorphism and mutation databases

DMDMⁱ	215274146

DMDMⁱ

215274146

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000053660	1 – 423	Steroid hormone receptor ERR1Add BLAST		423

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Cross-linkⁱ	14	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)2 Publications
Modified residueⁱ	19	PhosphoserineCombined sources2 Publications	1
Modified residueⁱ	22	PhosphoserineCombined sources2 Publications	1
Modified residueⁱ	129	N6-acetyllysine; by PCAF/KAT2B1 Publication	1
Modified residueⁱ	138	N6-acetyllysine; by PCAF/KAT2B1 Publication	1
Modified residueⁱ	160	N6-acetyllysine; by PCAF/KAT2B1 Publication	1
Modified residueⁱ	162	N6-acetyllysine; by PCAF/KAT2B1 Publication	1
Cross-linkⁱ	189	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	403	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate2 Publications
Cross-linkⁱ	403	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources

Post-translational modificationⁱ

Phosphorylation on Ser-19 enhances sumoylation on Lys-14 increasing repression of transcriptional activity.2 Publications

Sumoylated with SUMO2. Main site is Lys-14 which is enhanced by phosphorylation on Ser-19, cofactor activation, and by interaction with PIAS4. Sumoylation enhances repression of transcriptional activity, but has no effect on subcellular location nor on DNA binding.2 Publications

Reversibly acetylated. Acetylation by PCAF/KAT2 at Lys-129, Lys-138, Lys-160 and Lys-162 and PCAF/KAT2 decreases transcriptional activity probably by inhibiting DNA-binding activity; deacetylation involves SIRT1 and HDAC8 and increases DNA-binding.1 Publication

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P11474
PaxDbⁱ	P11474
PeptideAtlas More...PeptideAtlasⁱ	P11474
PRIDEⁱ	P11474
ProteomicsDBⁱ	52781 52782 [P11474-2]

PTM databases

iPTMnetⁱ	P11474
PhosphoSitePlusⁱ	P11474

Expressionⁱ

Inductionⁱ

Induced by PGC1alpha in a number of specific cell types including heart, kidney and muscle.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000173153 Expressed in 207 organ(s), highest expression level in apex of heart
CleanExⁱ	HS_ESRRA
ExpressionAtlasⁱ	P11474 baseline and differential
Genevisibleⁱ	P11474 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA053785

HPAⁱ

HPA053785

Interactionⁱ

Subunit structureⁱ

Binds DNA as a monomer or a homodimer. Interacts (via the AF2 domain) with coactivator PPARGC1A (via the L3 motif); the interaction greatly enhances transcriptional activity of genes involved in energy metabolism. Interacts with PIAS4; the interaction enhances sumoylation. Interacts with MAPK15; promotes re-localization of ESRRA to the cytoplasm through a XPO1-dependent mechanism then inhibits ESRRA transcriptional activity.5 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
HIF1A	Q16665	3	EBI-372412,EBI-447269
PIAS4	Q8N2W9	3	EBI-372412,EBI-473160
PPARGC1A	Q9UBK2	19	EBI-372412,EBI-765486

GO - Molecular functionⁱ

protein domain specific binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 11984006

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	108405, 38 interactors
Database of interacting proteins More...DIPⁱ	DIP-35053N
IntActⁱ	P11474, 28 interactors
Molecular INTeraction database More...MINTⁱ	P11474
STRINGⁱ	9606.ENSP00000000442

Chemistry databases

BindingDBⁱ

P11474

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	195 – 204	Combined sources	10
Helixⁱ	224 – 244	Combined sources	21
Helixⁱ	249 – 251	Combined sources	3
Helixⁱ	254 – 277	Combined sources	24
Beta strandⁱ	280 – 282	Combined sources	3
Beta strandⁱ	284 – 287	Combined sources	4
Beta strandⁱ	290 – 292	Combined sources	3
Helixⁱ	294 – 299	Combined sources	6
Turnⁱ	300 – 304	Combined sources	5
Helixⁱ	305 – 317	Combined sources	13
Turnⁱ	318 – 320	Combined sources	3
Helixⁱ	323 – 335	Combined sources	13
Helixⁱ	345 – 364	Combined sources	20
Helixⁱ	377 – 382	Combined sources	6
Helixⁱ	385 – 400	Combined sources	16
Helixⁱ	404 – 406	Combined sources	3
Helixⁱ	410 – 421	Combined sources	12

Show more details

3D structure databases

ProteinModelPortalⁱ	P11474
SMRⁱ	P11474
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P11474

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	193 – 421	NR LBDPROSITE-ProRule annotationAdd BLAST		229

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 76	Repressor domainAdd BLAST		76
Regionⁱ	403 – 423	AF-2 domainAdd BLAST		21

Sequence similaritiesⁱ

Belongs to the nuclear hormone receptor family. NR3 subfamily.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	79 – 99	NR C4-typePROSITE-ProRule annotationAdd BLAST		21
Zinc fingerⁱ	115 – 134	NR C4-typePROSITE-ProRule annotationAdd BLAST		20

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG3575 Eukaryota ENOG410XRZC LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118887
HOGENOMⁱ	HOG000233467
HOVERGENⁱ	HBG108344
InParanoidⁱ	P11474
KEGG Orthology (KO) More...KOⁱ	K08552
OMAⁱ	CHPGHKE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0DYP
PhylomeDBⁱ	P11474
TreeFamⁱ	TF323751

Family and domain databases

Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR035500 NHR_like_dom_sf IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR027289 Oest-rel_rcp IPR024178 Oest_rcpt/oest-rel_rcp IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit
PIRSFⁱ	PIRSF002527 ER-like_NR, 1 hit PIRSF500939 ERR1-2-3, 1 hit
PRINTSⁱ	PR00398 STRDHORMONER PR00047 STROIDFINGER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 2 hits
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P11474-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSQVVGIEP LYIKAEPASP DSPKGSSETE TEPPVALAPG PAPTRCLPGH 
        60         70         80         90        100
KEEEDGEGAG PGEQGGGKLV LSSLPKRLCL VCGDVASGYH YGVASCEACK 
       110        120        130        140        150
AFFKRTIQGS IEYSCPASNE CEITKRRRKA CQACRFTKCL RVGMLKEGVR 
       160        170        180        190        200
LDRVRGGRQK YKRRPEVDPL PFPGPFPAGP LAVAGGPRKT AAPVNALVSH 
       210        220        230        240        250
LLVVEPEKLY AMPDPAGPDG HLPAVATLCD LFDREIVVTI SWAKSIPGFS 
       260        270        280        290        300
SLSLSDQMSV LQSVWMEVLV LGVAQRSLPL QDELAFAEDL VLDEEGARAA 
       310        320        330        340        350
GLGELGAALL QLVRRLQALR LEREEYVLLK ALALANSDSV HIEDAEAVEQ 
       360        370        380        390        400
LREALHEALL EYEAGRAGPG GGAERRRAGR LLLTLPLLRQ TAGKVLAHFY 
       410        420 
GVKLEGKVPM HKLFLEMLEA MMD

Length:423

Mass (Da):45,510

Last modified:November 25, 2008 - v3

Checksum:ⁱBAE62DAF0BE6BA96

GO

Isoform 2 (identifier: P11474-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
191-191: Missing.

« Hide

        10         20         30         40         50
MSSQVVGIEP LYIKAEPASP DSPKGSSETE TEPPVALAPG PAPTRCLPGH 
        60         70         80         90        100
KEEEDGEGAG PGEQGGGKLV LSSLPKRLCL VCGDVASGYH YGVASCEACK 
       110        120        130        140        150
AFFKRTIQGS IEYSCPASNE CEITKRRRKA CQACRFTKCL RVGMLKEGVR 
       160        170        180        190        200
LDRVRGGRQK YKRRPEVDPL PFPGPFPAGP LAVAGGPRKT APVNALVSHL 
       210        220        230        240        250
LVVEPEKLYA MPDPAGPDGH LPAVATLCDL FDREIVVTIS WAKSIPGFSS 
       260        270        280        290        300
LSLSDQMSVL QSVWMEVLVL GVAQRSLPLQ DELAFAEDLV LDEEGARAAG 
       310        320        330        340        350
LGELGAALLQ LVRRLQALRL EREEYVLLKA LALANSDSVH IEDAEAVEQL 
       360        370        380        390        400
REALHEALLE YEAGRAGPGG GAERRRAGRL LLTLPLLRQT AGKVLAHFYG 
       410        420 
VKLEGKVPMH KLFLEMLEAM MD

Note: No experimental confirmation available.

Show »

Length:422

Mass (Da):45,439

Checksum:ⁱ482E152354383842

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F5GWT5	F5GWT5_HUMAN	Steroid hormone receptor ERR1 Steroid hormone receptor ERR1	ESRRA	109	Annotation score:
H0YGT3	H0YGT3_HUMAN	Steroid hormone receptor ERR1 Steroid hormone receptor ERR1	ESRRA	198	Annotation score:
F5H0E9	F5H0E9_HUMAN	Steroid hormone receptor ERR1 Steroid hormone receptor ERR1	ESRRA	162	Annotation score:

Sequence cautionⁱ

The sequence AAB17015 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence CAA35778 differs from that shown. Reason: Frameshift at positions 345 and 354.Curated

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_035756	191	Missing in isoform 2. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X51416 mRNA Translation: CAA35778.1 Frameshift. L38487 mRNA Translation: AAB17015.1 Different initiation. AP001453 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS41667.1 [P11474-1] CCDS60830.1 [P11474-2]
PIRⁱ	A29345
NCBI Reference Sequences More...RefSeqⁱ	NP_001269379.1, NM_001282450.1 [P11474-1] NP_001269380.1, NM_001282451.1 [P11474-2] NP_004442.3, NM_004451.4 [P11474-1]
UniGeneⁱ	Hs.110849

Genome annotation databases

Ensemblⁱ	ENST00000000442; ENSP00000000442; ENSG00000173153 [P11474-1] ENST00000405666; ENSP00000384851; ENSG00000173153 [P11474-1] ENST00000406310; ENSP00000385971; ENSG00000173153 [P11474-2]
GeneIDⁱ	2101
KEGGⁱ	hsa:2101
UCSC genome browser More...UCSCⁱ	uc001nzr.3 human [P11474-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P11474	ESRRA protein		HUMAN		423	UniRef100_P11474
ESRRA isoform 1		PANTR		423
ESRRA isoform 2		PONAB		423
Uncharacterized protein		PAPAN		423
ESRRA protein (Fragment)		HUMAN		320
+4
P11474-2	ESRRA isoform 2		PANTR		422	UniRef100_K7DJ98
steroid hormone receptor ERR1 isoform X1		Yangtze finless porpoise		584
Estrogen related receptor alpha		CERAT		422
Uncharacterized protein		COLAP		422
ESRRA isoform 1		PONAB		422
+7

Protein	Similar proteins		Species	Score	Length	Source
P11474	Steroid hormone receptor ERR1		CANLF		422	UniRef90_P11474
ESRRA protein		HUMAN		423
ESRRA isoform 1		PANTR		423
ESRRA isoform 2		PONAB		423
Uncharacterized protein		PAPAN		423
+75
P11474-2	ESRRA isoform 2		PANTR		422	UniRef90_K7DJ98
steroid hormone receptor ERR1 isoform X1		Yangtze finless porpoise		584
Estrogen related receptor alpha		CERAT		422
Uncharacterized protein		COLAP		422
ESRRA isoform 1		PONAB		422
+27

Protein	Similar proteins		Species	Score	Length	Source
P11474	Steroid hormone receptor ERR1		CANLF		422	UniRef50_P11474
ESRRA protein		HUMAN		423
ESRRA isoform 1		PANTR		423
ESRRA isoform 2		PONAB		423
Uncharacterized protein		PAPAN		423
+102
P11474-2	Steroid hormone receptor ERR1		MOUSE		422	UniRef50_O08580
Steroid hormone receptor ERR1		RAT		422
Steroid hormone receptor ERR1		CANLF		613
steroid hormone receptor ERR1 isoform X4		ODORO		212
steroid hormone receptor ERR1 isoform X5		Enhydra lutris kenyoni		212
+102

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X51416 mRNA Translation: CAA35778.1 Frameshift. L38487 mRNA Translation: AAB17015.1 Different initiation. AP001453 Genomic DNA No translation available.
CCDSⁱ	CCDS41667.1 [P11474-1] CCDS60830.1 [P11474-2]
PIRⁱ	A29345
RefSeqⁱ	NP_001269379.1, NM_001282450.1 [P11474-1] NP_001269380.1, NM_001282451.1 [P11474-2] NP_004442.3, NM_004451.4 [P11474-1]
UniGeneⁱ	Hs.110849

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1XB7	X-ray	2.50	A	194-423	[»]
	2PJL	X-ray	2.30	A/B	193-423	[»]
	3D24	X-ray	2.11	A/C	192-423	[»]
	3K6P	X-ray	2.00	A	193-423	[»]
ProteinModelPortalⁱ	P11474
SMRⁱ	P11474
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108405, 38 interactors
DIPⁱ	DIP-35053N
IntActⁱ	P11474, 28 interactors
MINTⁱ	P11474
STRINGⁱ	9606.ENSP00000000442

Chemistry databases

BindingDBⁱ	P11474
ChEMBLⁱ	CHEMBL3429
DrugBankⁱ	DB06833 1-CYCLOHEXYL-N-{[1-(4-METHYLPHENYL)-1H-INDOL-3-YL]METHYL}METHANAMINE DB00197 Troglitazone
GuidetoPHARMACOLOGYⁱ	622

PTM databases

iPTMnetⁱ	P11474
PhosphoSitePlusⁱ	P11474

Polymorphism and mutation databases

DMDMⁱ	215274146

DMDMⁱ

215274146

Proteomic databases

EPDⁱ	P11474
PaxDbⁱ	P11474
PeptideAtlasⁱ	P11474
PRIDEⁱ	P11474
ProteomicsDBⁱ	52781 52782 [P11474-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	2101
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000000442; ENSP00000000442; ENSG00000173153 [P11474-1] ENST00000405666; ENSP00000384851; ENSG00000173153 [P11474-1] ENST00000406310; ENSP00000385971; ENSG00000173153 [P11474-2]
GeneIDⁱ	2101
KEGGⁱ	hsa:2101
UCSCⁱ	uc001nzr.3 human [P11474-1]

Organism-specific databases

CTDⁱ	2101
DisGeNETⁱ	2101
EuPathDBⁱ	HostDB:ENSG00000173153.13
GeneCardsⁱ	ESRRA
HGNCⁱ	HGNC:3471 ESRRA
HPAⁱ	HPA053785
MIMⁱ	601998 gene
neXtProtⁱ	NX_P11474
OpenTargetsⁱ	ENSG00000173153
PharmGKBⁱ	PA27887
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3575 Eukaryota ENOG410XRZC LUCA
GeneTreeⁱ	ENSGT00760000118887
HOGENOMⁱ	HOG000233467
HOVERGENⁱ	HBG108344
InParanoidⁱ	P11474
KOⁱ	K08552
OMAⁱ	CHPGHKE
OrthoDBⁱ	EOG091G0DYP
PhylomeDBⁱ	P11474
TreeFamⁱ	TF323751

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1989781 PPARA activates gene expression R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis R-HSA-383280 Nuclear Receptor transcription pathway R-HSA-8939902 Regulation of RUNX2 expression and activity
SignaLinkⁱ	P11474
SIGNORⁱ	P11474

Miscellaneous databases

EvolutionaryTraceⁱ	P11474
GeneWikiⁱ	Estrogen-related_receptor_alpha
GenomeRNAiⁱ	2101
Protein Ontology More...PROⁱ	PR:P11474
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000173153 Expressed in 207 organ(s), highest expression level in apex of heart
CleanExⁱ	HS_ESRRA
ExpressionAtlasⁱ	P11474 baseline and differential
Genevisibleⁱ	P11474 HS

Family and domain databases

Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR035500 NHR_like_dom_sf IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR027289 Oest-rel_rcp IPR024178 Oest_rcpt/oest-rel_rcp IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA
Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit
PIRSFⁱ	PIRSF002527 ER-like_NR, 1 hit PIRSF500939 ERR1-2-3, 1 hit
PRINTSⁱ	PR00398 STRDHORMONER PR00047 STROIDFINGER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 2 hits
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ERR1_HUMAN
Accessionⁱ	P11474Primary (citable) accession number: P11474 Secondary accession number(s): Q14514
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
	Last sequence update:	November 25, 2008
	Last modified:	October 10, 2018
	This is version 206 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - P11474 (ERR1_HUMAN)

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Steroid hormone receptor ERR1

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Sequence databases

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Protocols and materials databases

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Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ