UniProtKB - P11473 (VDR_HUMAN)
Vitamin D3 receptor
VDR
Functioni
Caution
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 143 | Vitamin D3 | 1 | |
Binding sitei | 305 | Vitamin D3 | 1 | |
Binding sitei | 397 | Vitamin D3 | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 21 – 96 | Nuclear receptorPROSITE-ProRule annotationAdd BLAST | 76 | |
Zinc fingeri | 24 – 44 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 60 – 84 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- calcitriol binding Source: UniProtKB
- DNA binding Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- lithocholic acid binding Source: UniProtKB
- lithocholic acid receptor activity Source: UniProtKB
- nuclear receptor activity Source: UniProtKB
- retinoid X receptor binding Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- zinc ion binding Source: InterPro
GO - Biological processi
- bile acid signaling pathway Source: UniProtKB
- cell differentiation Source: GO_Central
- cell morphogenesis Source: UniProtKB
- cholesterol homeostasis Source: GO_Central
- decidualization Source: BHF-UCL
- lipid homeostasis Source: GO_Central
- lipid metabolic process Source: GO_Central
- multicellular organism development Source: GO_Central
- negative regulation of cell population proliferation Source: BHF-UCL
- negative regulation of gene expression Source: ARUK-UCL
- negative regulation of keratinocyte proliferation Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: MGI
- negative regulation of transcription by RNA polymerase II Source: BHF-UCL
- positive regulation of gene expression Source: UniProtKB
- positive regulation of keratinocyte differentiation Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- positive regulation of vitamin D 24-hydroxylase activity Source: BHF-UCL
- regulation of calcidiol 1-monooxygenase activity Source: BHF-UCL
- transcription initiation from RNA polymerase II promoter Source: Reactome
- vitamin D metabolic process Source: Reactome
- vitamin D receptor signaling pathway Source: BHF-UCL
Keywordsi
Molecular function | DNA-binding, Receptor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | P11473 |
Reactomei | R-HSA-196791, Vitamin D (calciferol) metabolism R-HSA-383280, Nuclear Receptor transcription pathway R-HSA-4090294, SUMOylation of intracellular receptors |
SignaLinki | P11473 |
SIGNORi | P11473 |
Protein family/group databases
MoonDBi | P11473, Predicted |
TCDBi | 9.B.208.1.1, the vitamin d3 receptor (vdr) family |
Chemistry databases
SwissLipidsi | SLP:000001571 |
Names & Taxonomyi
Protein namesi | Recommended name: Vitamin D3 receptorShort name: VDR Alternative name(s): 1,25-dihydroxyvitamin D3 receptor Nuclear receptor subfamily 1 group I member 1 |
Gene namesi | Name:VDR Synonyms:NR1I1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12679, VDR |
MIMi | 601769, gene |
neXtProti | NX_P11473 |
VEuPathDBi | HostDB:ENSG00000111424.10 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Nucleus
- nuclear chromatin Source: NTNU_SB
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- receptor complex Source: BHF-UCL
- RNA polymerase II transcription regulator complex Source: BHF-UCL
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Involvement in diseasei
Rickets vitamin D-dependent 2A (VDDR2A)12 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_004656 | 33 | G → D in VDDR2A. 1 PublicationCorresponds to variant dbSNP:rs121909790EnsemblClinVar. | 1 | |
Natural variantiVAR_004657 | 35 | H → Q in VDDR2A. 1 Publication | 1 | |
Natural variantiVAR_004658 | 45 | K → E in VDDR2A. 1 Publication | 1 | |
Natural variantiVAR_004659 | 46 | G → D in VDDR2A. 1 PublicationCorresponds to variant dbSNP:rs121909797EnsemblClinVar. | 1 | |
Natural variantiVAR_004660 | 47 | F → I in VDDR2A. 1 Publication | 1 | |
Natural variantiVAR_004661 | 50 | R → Q in VDDR2A. 1 PublicationCorresponds to variant dbSNP:rs121909794EnsemblClinVar. | 1 | |
Natural variantiVAR_004662 | 73 | R → Q in VDDR2A. 1 PublicationCorresponds to variant dbSNP:rs121909791EnsemblClinVar. | 1 | |
Natural variantiVAR_004663 | 80 | R → Q in VDDR2A. 2 PublicationsCorresponds to variant dbSNP:rs121909793EnsemblClinVar. | 1 | |
Natural variantiVAR_079325 | 152 – 427 | Missing in VDDR2A; loss of calcitriol receptor activity; loss of affinity for calcitriol; no effect on ligand-independent localization to the nucleus. 2 PublicationsCorresponds to variant dbSNP:rs121909795Add BLAST | 276 | |
Natural variantiVAR_004664 | 274 | R → L in VDDR2A; loss of calcitriol receptor activity; decreased affinity for calcitriol by a factor of 1000; no effect on interaction with RXRA; changed interaction with NCOR1; loss of interaction with NCOA1; no effect on sequence-specific DNA-binding. 2 PublicationsCorresponds to variant dbSNP:rs121909796EnsemblClinVar. | 1 | |
Natural variantiVAR_004665 | 305 | H → Q in VDDR2A; loss of calcitriol receptor activity; no effect on interaction with RXRA; changed interaction with NCOR1; loss of interaction with NCOA1; no effect on sequence-specific DNA-binding. 2 PublicationsCorresponds to variant dbSNP:rs121909798EnsemblClinVar. | 1 | |
Natural variantiVAR_004666 | 314 | I → S in VDDR2A. 1 PublicationCorresponds to variant dbSNP:rs121909799EnsemblClinVar. | 1 | |
Natural variantiVAR_079326 | 346 | V → M in VDDR2A; decreased calcitriol receptor activity; decreased affinity for calcitriol; decreased ligand-independent localization to the nucleus; loss of interaction with RXRA; decreased interaction with NCOR1; decreased interaction with NCOA1; decreased sequence-specific DNA-binding. 2 PublicationsCorresponds to variant dbSNP:rs267607169EnsemblClinVar. | 1 | |
Natural variantiVAR_079327 | 360 | S → P in VDDR2A; loss of calcitriol receptor activity; loss of affinity for calcitriol; decreased ligand-independent localization to the nucleus; loss of interaction with RXRA; loss of interaction with NCOR1; loss of interaction with NCOA1; loss of sequence-specific DNA-binding. 1 Publication | 1 | |
Natural variantiVAR_004667 | 391 | R → C in VDDR2A. 1 PublicationCorresponds to variant dbSNP:rs121909800EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 47 – 48 | FF → AA: Abolishes nuclear export. 1 Publication | 2 | |
Mutagenesisi | 61 – 62 | PF → AA: Promotes heterodimerization with RXRA; when associated with A-75. 1 Publication | 2 | |
Mutagenesisi | 75 | H → A: Promotes heterodimerization with RXRA; when associated with A-61 and A-62. 1 Publication | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 7421 |
MalaCardsi | VDR |
MIMi | 277440, phenotype 607948, phenotype |
OpenTargetsi | ENSG00000111424 |
Orphaneti | 93160, Hypocalcemic vitamin D-resistant rickets |
PharmGKBi | PA37301 |
Miscellaneous databases
Pharosi | P11473, Tclin |
Chemistry databases
ChEMBLi | CHEMBL1977 |
DrugBanki | DB07530, (1R,3R)-5-[(2E)-3-{(1S,3R)-2,2,3-trimethyl-3-[6,6,6-trifluoro-5-hydroxy-5-(trifluoromethyl)hex-3-yn-1-yl]cyclopentyl}prop-2-en-1-ylidene]cyclohexane-1,3-diol DB08742, 1,3-CYCLOHEXANEDIOL, 4-METHYLENE-5-[(2E)-[(1S,3AS,7AS)-OCTAHYDRO-1-(5-HYDROXY-5-METHYL-1,3-HEXADIYNYL)-7A-METHYL-4H-INDEN-4-YLIDENE]ETHYLIDENE]-, (1R,3S,5Z) DB01436, Alfacalcidol DB04891, Becocalcidiol DB00146, Calcifediol DB02300, Calcipotriol DB00136, Calcitriol DB00169, Cholecalciferol DB04540, Cholesterol DB05024, CTA018 DB11672, Curcumin DB14635, Curcumin sulfate DB01070, Dihydrotachysterol DB06410, Doxercalciferol DB05295, Eldecalcitol DB06194, Elocalcitol DB00153, Ergocalciferol DB04796, Inecalcitol DB03451, Lexacalcitol DB00910, Paricalcitol DB04258, Seocalcitol DB11094, Vitamin D |
DrugCentrali | P11473 |
GuidetoPHARMACOLOGYi | 605 |
Genetic variation databases
BioMutai | VDR |
DMDMi | 137617 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000053542 | 1 – 427 | Vitamin D3 receptorAdd BLAST | 427 |
Proteomic databases
EPDi | P11473 |
jPOSTi | P11473 |
MassIVEi | P11473 |
MaxQBi | P11473 |
PaxDbi | P11473 |
PeptideAtlasi | P11473 |
PRIDEi | P11473 |
ProteomicsDBi | 32456 52780 [P11473-1] |
PTM databases
iPTMneti | P11473 |
PhosphoSitePlusi | P11473 |
Expressioni
Gene expression databases
Bgeei | ENSG00000111424, Expressed in tibia and 195 other tissues |
ExpressionAtlasi | P11473, baseline and differential |
Genevisiblei | P11473, HS |
Organism-specific databases
HPAi | ENSG00000111424, Tissue enhanced (intestine, parathyroid gland) |
Interactioni
Subunit structurei
Homodimer in the absence of bound vitamin D3 (PubMed:11980721). Heterodimer with RXRA after vitamin D3 binding (PubMed:15225774, PubMed:11980721, PubMed:10678179).
Interacts with MED1, NCOA1, NCOA2, NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes (PubMed:10866662, PubMed:15728261, PubMed:28698609, PubMed:9267036).
Interacts with the corepressor NCOR1 (PubMed:28698609).
Interacts with SNW1 (PubMed:9632709).
Interacts with IRX4, the interaction does not affect its transactivation activity (PubMed:22323358).
Interacts with CRY1 (By similarity).
Interacts with CRY2 in a ligand-dependent manner (By similarity).
By similarity9 PublicationsBinary interactionsi
Hide detailsP11473
Isoform 2 [P11473-2]
GO - Molecular functioni
- retinoid X receptor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 113264, 103 interactors |
ComplexPortali | CPX-631, RXRalpha-VDR nuclear hormone receptor complex CPX-871, RXRbeta-VDR nuclear hormone receptor complex |
CORUMi | P11473 |
DIPi | DIP-32624N |
ELMi | P11473 |
IntActi | P11473, 34 interactors |
MINTi | P11473 |
STRINGi | 9606.ENSP00000447173 |
Chemistry databases
BindingDBi | P11473 |
Miscellaneous databases
RNActi | P11473, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P11473 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P11473 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 127 – 423 | NR LBDPROSITE-ProRule annotationAdd BLAST | 297 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 97 – 126 | HingeAdd BLAST | 30 | |
Regioni | 227 – 237 | Vitamin D3 bindingAdd BLAST | 11 | |
Regioni | 271 – 278 | Vitamin D3 binding | 8 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 416 – 424 | 9aaTAD1 Publication | 9 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 24 – 44 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 60 – 84 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00940000155473 |
InParanoidi | P11473 |
OMAi | YADFTQF |
OrthoDBi | 297114at2759 |
PhylomeDBi | P11473 |
TreeFami | TF316304 |
Family and domain databases
CDDi | cd06955, NR_DBD_VDR, 1 hit |
DisProti | DP00184 |
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR042153, DBD_VDR IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR000324, VitD_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR00398, STRDHORMONER PR00047, STROIDFINGER PR00350, VITAMINDR |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEAMAASTSL PDPGDFDRNV PRICGVCGDR ATGFHFNAMT CEGCKGFFRR
60 70 80 90 100
SMKRKALFTC PFNGDCRITK DNRRHCQACR LKRCVDIGMM KEFILTDEEV
110 120 130 140 150
QRKREMILKR KEEEALKDSL RPKLSEEQQR IIAILLDAHH KTYDPTYSDF
160 170 180 190 200
CQFRPPVRVN DGGGSHPSRP NSRHTPSFSG DSSSSCSDHC ITSSDMMDSS
210 220 230 240 250
SFSNLDLSEE DSDDPSVTLE LSQLSMLPHL ADLVSYSIQK VIGFAKMIPG
260 270 280 290 300
FRDLTSEDQI VLLKSSAIEV IMLRSNESFT MDDMSWTCGN QDYKYRVSDV
310 320 330 340 350
TKAGHSLELI EPLIKFQVGL KKLNLHEEEH VLLMAICIVS PDRPGVQDAA
360 370 380 390 400
LIEAIQDRLS NTLQTYIRCR HPPPGSHLLY AKMIQKLADL RSLNEEHSKQ
410 420
YRCLSFQPEC SMKLTPLVLE VFGNEIS
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A5K1VW50 | A0A5K1VW50_HUMAN | 1,25-dihydroxyvitamin D3 receptor | VDR | 494 | Annotation score: | ||
F8VRJ4 | F8VRJ4_HUMAN | 1,25-dihydroxyvitamin D3 receptor | VDR | 250 | Annotation score: | ||
F8VVY8 | F8VVY8_HUMAN | Vitamin D3 receptor | VDR | 106 | Annotation score: | ||
F8VPF8 | F8VPF8_HUMAN | Vitamin D3 receptor | VDR | 101 | Annotation score: | ||
F8VXQ9 | F8VXQ9_HUMAN | Vitamin D3 receptor | VDR | 49 | Annotation score: |
Sequence cautioni
Polymorphismi
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_004656 | 33 | G → D in VDDR2A. 1 PublicationCorresponds to variant dbSNP:rs121909790EnsemblClinVar. | 1 | |
Natural variantiVAR_004657 | 35 | H → Q in VDDR2A. 1 Publication | 1 | |
Natural variantiVAR_004658 | 45 | K → E in VDDR2A. 1 Publication | 1 | |
Natural variantiVAR_004659 | 46 | G → D in VDDR2A. 1 PublicationCorresponds to variant dbSNP:rs121909797EnsemblClinVar. | 1 | |
Natural variantiVAR_004660 | 47 | F → I in VDDR2A. 1 Publication | 1 | |
Natural variantiVAR_004661 | 50 | R → Q in VDDR2A. 1 PublicationCorresponds to variant dbSNP:rs121909794EnsemblClinVar. | 1 | |
Natural variantiVAR_004662 | 73 | R → Q in VDDR2A. 1 PublicationCorresponds to variant dbSNP:rs121909791EnsemblClinVar. | 1 | |
Natural variantiVAR_004663 | 80 | R → Q in VDDR2A. 2 PublicationsCorresponds to variant dbSNP:rs121909793EnsemblClinVar. | 1 | |
Natural variantiVAR_079325 | 152 – 427 | Missing in VDDR2A; loss of calcitriol receptor activity; loss of affinity for calcitriol; no effect on ligand-independent localization to the nucleus. 2 PublicationsCorresponds to variant dbSNP:rs121909795Add BLAST | 276 | |
Natural variantiVAR_029309 | 230 | L → V1 PublicationCorresponds to variant dbSNP:rs11574090Ensembl. | 1 | |
Natural variantiVAR_004664 | 274 | R → L in VDDR2A; loss of calcitriol receptor activity; decreased affinity for calcitriol by a factor of 1000; no effect on interaction with RXRA; changed interaction with NCOR1; loss of interaction with NCOA1; no effect on sequence-specific DNA-binding. 2 PublicationsCorresponds to variant dbSNP:rs121909796EnsemblClinVar. | 1 | |
Natural variantiVAR_004665 | 305 | H → Q in VDDR2A; loss of calcitriol receptor activity; no effect on interaction with RXRA; changed interaction with NCOR1; loss of interaction with NCOA1; no effect on sequence-specific DNA-binding. 2 PublicationsCorresponds to variant dbSNP:rs121909798EnsemblClinVar. | 1 | |
Natural variantiVAR_004666 | 314 | I → S in VDDR2A. 1 PublicationCorresponds to variant dbSNP:rs121909799EnsemblClinVar. | 1 | |
Natural variantiVAR_079326 | 346 | V → M in VDDR2A; decreased calcitriol receptor activity; decreased affinity for calcitriol; decreased ligand-independent localization to the nucleus; loss of interaction with RXRA; decreased interaction with NCOR1; decreased interaction with NCOA1; decreased sequence-specific DNA-binding. 2 PublicationsCorresponds to variant dbSNP:rs267607169EnsemblClinVar. | 1 | |
Natural variantiVAR_079327 | 360 | S → P in VDDR2A; loss of calcitriol receptor activity; loss of affinity for calcitriol; decreased ligand-independent localization to the nucleus; loss of interaction with RXRA; loss of interaction with NCOR1; loss of interaction with NCOA1; loss of sequence-specific DNA-binding. 1 Publication | 1 | |
Natural variantiVAR_029310 | 362 | T → I1 PublicationCorresponds to variant dbSNP:rs11574115EnsemblClinVar. | 1 | |
Natural variantiVAR_004667 | 391 | R → C in VDDR2A. 1 PublicationCorresponds to variant dbSNP:rs121909800EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_047218 | 1 | M → MEWRNKKRSDWLSMVLRTAG VEEAFGSEVSVRPHRRAPLG STYLPPAPSGM in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03258 mRNA Translation: AAA61273.1 X67482 mRNA Translation: CAA47824.1 AF026260 mRNA Translation: AAB95155.1 AB002168 Genomic DNA Translation: BAA83389.1 AY342401 Genomic DNA Translation: AAP88938.1 Sequence problems. AK312267 mRNA Translation: BAG35198.1 AC004466 Genomic DNA No translation available. AC121338 Genomic DNA No translation available. CH471111 Genomic DNA Translation: EAW57960.1 CH471111 Genomic DNA Translation: EAW57961.1 BC060832 mRNA Translation: AAH60832.1 Different initiation. M65208 mRNA Translation: AAA61274.1 AY827087 Genomic DNA Translation: AAV85448.1 |
CCDSi | CCDS55820.1 [P11473-2] CCDS8757.1 [P11473-1] |
PIRi | A28200 |
RefSeqi | NP_000367.1, NM_000376.2 [P11473-1] NP_001017535.1, NM_001017535.1 [P11473-1] NP_001017536.1, NM_001017536.1 [P11473-2] XP_006719650.1, XM_006719587.3 XP_011537022.1, XM_011538720.2 [P11473-1] |
Genome annotation databases
Ensembli | ENST00000395324; ENSP00000378734; ENSG00000111424 [P11473-1] ENST00000549336; ENSP00000449573; ENSG00000111424 [P11473-1] ENST00000550325; ENSP00000447173; ENSG00000111424 [P11473-2] |
GeneIDi | 7421 |
KEGGi | hsa:7421 |
UCSCi | uc001rql.4, human [P11473-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
SHMPD The Singapore human mutation and polymorphism database |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03258 mRNA Translation: AAA61273.1 X67482 mRNA Translation: CAA47824.1 AF026260 mRNA Translation: AAB95155.1 AB002168 Genomic DNA Translation: BAA83389.1 AY342401 Genomic DNA Translation: AAP88938.1 Sequence problems. AK312267 mRNA Translation: BAG35198.1 AC004466 Genomic DNA No translation available. AC121338 Genomic DNA No translation available. CH471111 Genomic DNA Translation: EAW57960.1 CH471111 Genomic DNA Translation: EAW57961.1 BC060832 mRNA Translation: AAH60832.1 Different initiation. M65208 mRNA Translation: AAA61274.1 AY827087 Genomic DNA Translation: AAV85448.1 |
CCDSi | CCDS55820.1 [P11473-2] CCDS8757.1 [P11473-1] |
PIRi | A28200 |
RefSeqi | NP_000367.1, NM_000376.2 [P11473-1] NP_001017535.1, NM_001017535.1 [P11473-1] NP_001017536.1, NM_001017536.1 [P11473-2] XP_006719650.1, XM_006719587.3 XP_011537022.1, XM_011538720.2 [P11473-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1DB1 | X-ray | 1.80 | A | 118-427 | [»] | |
1IE8 | X-ray | 1.52 | A | 118-427 | [»] | |
1IE9 | X-ray | 1.40 | A | 118-427 | [»] | |
1KB2 | X-ray | 2.70 | A/B | 16-125 | [»] | |
1KB4 | X-ray | 2.80 | A/B | 16-125 | [»] | |
1KB6 | X-ray | 2.70 | A/B | 16-125 | [»] | |
1S0Z | X-ray | 2.50 | A | 118-427 | [»] | |
1S19 | X-ray | 2.10 | A | 118-427 | [»] | |
1TXI | X-ray | 1.90 | A | 118-427 | [»] | |
1YNW | X-ray | 3.00 | A | 16-125 | [»] | |
2HAM | X-ray | 1.90 | A | 118-427 | [»] | |
2HAR | X-ray | 1.90 | A | 118-427 | [»] | |
2HAS | X-ray | 1.96 | A | 118-427 | [»] | |
2HB7 | X-ray | 1.80 | A | 118-427 | [»] | |
2HB8 | X-ray | 2.00 | A | 118-427 | [»] | |
3A2I | X-ray | 3.27 | A | 118-427 | [»] | |
3A2J | X-ray | 2.70 | A | 118-427 | [»] | |
3A3Z | X-ray | 1.72 | X | 118-427 | [»] | |
3A40 | X-ray | 1.45 | X | 118-427 | [»] | |
3A78 | X-ray | 1.90 | A | 118-427 | [»] | |
3AUQ | X-ray | 2.64 | A | 118-427 | [»] | |
3AUR | X-ray | 2.21 | A | 118-427 | [»] | |
3AX8 | X-ray | 2.60 | A | 118-427 | [»] | |
3AZ1 | X-ray | 1.50 | A | 120-423 | [»] | |
3AZ2 | X-ray | 1.69 | A | 120-423 | [»] | |
3AZ3 | X-ray | 1.36 | A | 120-423 | [»] | |
3B0T | X-ray | 1.30 | A | 120-423 | [»] | |
3CS4 | X-ray | 2.00 | A | 118-427 | [»] | |
3CS6 | X-ray | 1.80 | A | 118-427 | [»] | |
3KPZ | X-ray | 1.90 | A | 118-427 | [»] | |
3M7R | X-ray | 1.80 | A | 120-423 | [»] | |
3OGT | X-ray | 1.75 | A | 118-427 | [»] | |
3P8X | X-ray | 1.70 | A | 118-164 | [»] | |
A | 217-427 | [»] | ||||
3TKC | X-ray | 1.75 | A | 118-427 | [»] | |
3VHW | X-ray | 2.43 | A | 118-427 | [»] | |
3W0A | X-ray | 1.80 | A | 120-423 | [»] | |
3W0C | X-ray | 1.90 | A | 120-423 | [»] | |
3W0Y | X-ray | 1.98 | A | 120-423 | [»] | |
3WGP | X-ray | 2.00 | A | 120-423 | [»] | |
3WWR | X-ray | 3.18 | A | 118-427 | [»] | |
3X31 | X-ray | 2.11 | A | 118-427 | [»] | |
3X36 | X-ray | 1.93 | A | 118-427 | [»] | |
4G2I | X-ray | 1.80 | A | 118-427 | [»] | |
4ITE | X-ray | 2.49 | A | 118-427 | [»] | |
4ITF | X-ray | 2.84 | A | 118-427 | [»] | |
5GT4 | X-ray | 1.83 | A | 118-423 | [»] | |
5V39 | X-ray | 2.20 | A | 119-425 | [»] | |
5YSY | X-ray | 2.00 | A | 118-423 | [»] | |
5YT2 | X-ray | 2.00 | A | 118-423 | [»] | |
SMRi | P11473 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 113264, 103 interactors |
ComplexPortali | CPX-631, RXRalpha-VDR nuclear hormone receptor complex CPX-871, RXRbeta-VDR nuclear hormone receptor complex |
CORUMi | P11473 |
DIPi | DIP-32624N |
ELMi | P11473 |
IntActi | P11473, 34 interactors |
MINTi | P11473 |
STRINGi | 9606.ENSP00000447173 |
Chemistry databases
BindingDBi | P11473 |
ChEMBLi | CHEMBL1977 |
DrugBanki | DB07530, (1R,3R)-5-[(2E)-3-{(1S,3R)-2,2,3-trimethyl-3-[6,6,6-trifluoro-5-hydroxy-5-(trifluoromethyl)hex-3-yn-1-yl]cyclopentyl}prop-2-en-1-ylidene]cyclohexane-1,3-diol DB08742, 1,3-CYCLOHEXANEDIOL, 4-METHYLENE-5-[(2E)-[(1S,3AS,7AS)-OCTAHYDRO-1-(5-HYDROXY-5-METHYL-1,3-HEXADIYNYL)-7A-METHYL-4H-INDEN-4-YLIDENE]ETHYLIDENE]-, (1R,3S,5Z) DB01436, Alfacalcidol DB04891, Becocalcidiol DB00146, Calcifediol DB02300, Calcipotriol DB00136, Calcitriol DB00169, Cholecalciferol DB04540, Cholesterol DB05024, CTA018 DB11672, Curcumin DB14635, Curcumin sulfate DB01070, Dihydrotachysterol DB06410, Doxercalciferol DB05295, Eldecalcitol DB06194, Elocalcitol DB00153, Ergocalciferol DB04796, Inecalcitol DB03451, Lexacalcitol DB00910, Paricalcitol DB04258, Seocalcitol DB11094, Vitamin D |
DrugCentrali | P11473 |
GuidetoPHARMACOLOGYi | 605 |
SwissLipidsi | SLP:000001571 |
Protein family/group databases
MoonDBi | P11473, Predicted |
TCDBi | 9.B.208.1.1, the vitamin d3 receptor (vdr) family |
PTM databases
iPTMneti | P11473 |
PhosphoSitePlusi | P11473 |
Genetic variation databases
BioMutai | VDR |
DMDMi | 137617 |
Proteomic databases
EPDi | P11473 |
jPOSTi | P11473 |
MassIVEi | P11473 |
MaxQBi | P11473 |
PaxDbi | P11473 |
PeptideAtlasi | P11473 |
PRIDEi | P11473 |
ProteomicsDBi | 32456 52780 [P11473-1] |
Protocols and materials databases
Antibodypediai | 3902, 775 antibodies |
DNASUi | 7421 |
Genome annotation databases
Ensembli | ENST00000395324; ENSP00000378734; ENSG00000111424 [P11473-1] ENST00000549336; ENSP00000449573; ENSG00000111424 [P11473-1] ENST00000550325; ENSP00000447173; ENSG00000111424 [P11473-2] |
GeneIDi | 7421 |
KEGGi | hsa:7421 |
UCSCi | uc001rql.4, human [P11473-1] |
Organism-specific databases
CTDi | 7421 |
DisGeNETi | 7421 |
GeneCardsi | VDR |
HGNCi | HGNC:12679, VDR |
HPAi | ENSG00000111424, Tissue enhanced (intestine, parathyroid gland) |
MalaCardsi | VDR |
MIMi | 277440, phenotype 601769, gene 607948, phenotype |
neXtProti | NX_P11473 |
OpenTargetsi | ENSG00000111424 |
Orphaneti | 93160, Hypocalcemic vitamin D-resistant rickets |
PharmGKBi | PA37301 |
VEuPathDBi | HostDB:ENSG00000111424.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00940000155473 |
InParanoidi | P11473 |
OMAi | YADFTQF |
OrthoDBi | 297114at2759 |
PhylomeDBi | P11473 |
TreeFami | TF316304 |
Enzyme and pathway databases
PathwayCommonsi | P11473 |
Reactomei | R-HSA-196791, Vitamin D (calciferol) metabolism R-HSA-383280, Nuclear Receptor transcription pathway R-HSA-4090294, SUMOylation of intracellular receptors |
SignaLinki | P11473 |
SIGNORi | P11473 |
Miscellaneous databases
BioGRID-ORCSi | 7421, 6 hits in 894 CRISPR screens |
ChiTaRSi | VDR, human |
EvolutionaryTracei | P11473 |
GeneWikii | Calcitriol_receptor |
GenomeRNAii | 7421 |
Pharosi | P11473, Tclin |
PROi | PR:P11473 |
RNActi | P11473, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000111424, Expressed in tibia and 195 other tissues |
ExpressionAtlasi | P11473, baseline and differential |
Genevisiblei | P11473, HS |
Family and domain databases
CDDi | cd06955, NR_DBD_VDR, 1 hit |
DisProti | DP00184 |
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR042153, DBD_VDR IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR000324, VitD_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR00398, STRDHORMONER PR00047, STROIDFINGER PR00350, VITAMINDR |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | VDR_HUMAN | |
Accessioni | P11473Primary (citable) accession number: P11473 Secondary accession number(s): B2R5Q1, G3V1V9, Q5PSV3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1989 |
Last sequence update: | October 1, 1989 | |
Last modified: | February 10, 2021 | |
This is version 242 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families