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Protein

Pregnancy-specific beta-1-glycoprotein 2

Gene

PSG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • cell migration Source: UniProtKB
  • female pregnancy Source: UniProtKB

Enzyme and pathway databases

ReactomeiR-HSA-202733 Cell surface interactions at the vascular wall

Names & Taxonomyi

Protein namesi
Recommended name:
Pregnancy-specific beta-1-glycoprotein 2
Short name:
PS-beta-G-2
Short name:
PSBG-2
Short name:
Pregnancy-specific glycoprotein 2
Alternative name(s):
Pregnancy-specific beta-1 glycoprotein E
Short name:
PS-beta-E
Gene namesi
Name:PSG2
Synonyms:PSBG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000242221.8
HGNCiHGNC:9519 PSG2
MIMi176391 gene
neXtProtiNX_P11465

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi5670
OpenTargetsiENSG00000242221
PharmGKBiPA33864

Polymorphism and mutation databases

BioMutaiPSG2
DMDMi108935879

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Add BLAST34
ChainiPRO_000001490935 – 335Pregnancy-specific beta-1-glycoprotein 2Add BLAST301

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi61N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi111N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi169 ↔ 217Curated
Glycosylationi199N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi261 ↔ 301Curated

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP11465
PeptideAtlasiP11465
PRIDEiP11465
ProteomicsDBi52779

PTM databases

iPTMnetiP11465
PhosphoSitePlusiP11465

Expressioni

Gene expression databases

BgeeiENSG00000242221 Expressed in 56 organ(s), highest expression level in placenta
CleanExiHS_PSG2
ExpressionAtlasiP11465 baseline and differential
GenevisibleiP11465 HS

Interactioni

Protein-protein interaction databases

BioGridi111645, 2 interactors
IntActiP11465, 1 interactor
MINTiP11465
STRINGi9606.ENSP00000385706

Structurei

3D structure databases

ProteinModelPortaliP11465
SMRiP11465
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 144Ig-like V-typeAdd BLAST110
Domaini147 – 234Ig-like C2-type 1Add BLAST88
Domaini239 – 317Ig-like C2-type 2Add BLAST79

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410KC7S Eukaryota
ENOG4110P8V LUCA
GeneTreeiENSGT00760000119187
HOGENOMiHOG000233417
HOVERGENiHBG007922
InParanoidiP11465
KOiK06500
OMAiINEGDEY
OrthoDBiEOG091G0AMM
PhylomeDBiP11465
TreeFamiTF336859

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF13895 Ig_2, 1 hit
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P11465-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGPLSAPPCT EHIKWKGLLV TASLLNFWNL PTTAQVTIEA QPPKVSEGKD
60 70 80 90 100
VLLLVHNLPQ NLTGYIWYKG QIRDLYHYIT SYVVDGQIII YGPAYSGRET
110 120 130 140 150
AYSNASLLIQ NVTREDAGSY TLHIIKRGDG TRGVTGYFTF TLYLETPKPS
160 170 180 190 200
ISSSNLNPRE AMETVILTCD PETPDTSYQW WMNGQSLPMT HRFQLSETNR
210 220 230 240 250
TLFLFGVTKY TAGPYECEIR NSGSASRSDP VTLNLLHGPD LPRIHPSYTN
260 270 280 290 300
YRSGDNLYLS CFANSNPPAQ YSWTINGKFQ QSGQNLFIPQ ITTKHSGLYV
310 320 330
CSVRNSATGE ESSTSLTVKV SASTRIGLLP LLNPT
Length:335
Mass (Da):37,216
Last modified:June 13, 2006 - v2
Checksum:iC47AFC14DED9C0F8
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MR77A0A0A0MR77_HUMAN
Pregnancy-specific beta-1-glycoprot...
PSG2
117Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti310E → Q in AAA52604 (PubMed:3260773).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01603920V → L1 PublicationCorresponds to variant dbSNP:rs3887660Ensembl.1
Natural variantiVAR_049918176T → A. Corresponds to variant dbSNP:rs16976431Ensembl.1
Natural variantiVAR_049919179Q → L. Corresponds to variant dbSNP:rs1058086Ensembl.1
Natural variantiVAR_049920335T → R. Corresponds to variant dbSNP:rs1064937Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20882 mRNA Translation: AAA52604.1
AC005791 Genomic DNA Translation: AAC62831.1
AC024077 Genomic DNA No translation available.
BC022316 mRNA Translation: AAH22316.1
AH007518 Genomic DNA Translation: AAD21021.1
CCDSiCCDS12616.1
RefSeqiNP_112536.2, NM_031246.3
UniGeneiHs.709200

Genome annotation databases

EnsembliENST00000406487; ENSP00000385706; ENSG00000242221
GeneIDi5670
KEGGihsa:5670
UCSCiuc002ovr.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20882 mRNA Translation: AAA52604.1
AC005791 Genomic DNA Translation: AAC62831.1
AC024077 Genomic DNA No translation available.
BC022316 mRNA Translation: AAH22316.1
AH007518 Genomic DNA Translation: AAD21021.1
CCDSiCCDS12616.1
RefSeqiNP_112536.2, NM_031246.3
UniGeneiHs.709200

3D structure databases

ProteinModelPortaliP11465
SMRiP11465
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111645, 2 interactors
IntActiP11465, 1 interactor
MINTiP11465
STRINGi9606.ENSP00000385706

PTM databases

iPTMnetiP11465
PhosphoSitePlusiP11465

Polymorphism and mutation databases

BioMutaiPSG2
DMDMi108935879

Proteomic databases

PaxDbiP11465
PeptideAtlasiP11465
PRIDEiP11465
ProteomicsDBi52779

Protocols and materials databases

DNASUi5670
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000406487; ENSP00000385706; ENSG00000242221
GeneIDi5670
KEGGihsa:5670
UCSCiuc002ovr.4 human

Organism-specific databases

CTDi5670
DisGeNETi5670
EuPathDBiHostDB:ENSG00000242221.8
GeneCardsiPSG2
HGNCiHGNC:9519 PSG2
MIMi176391 gene
neXtProtiNX_P11465
OpenTargetsiENSG00000242221
PharmGKBiPA33864
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KC7S Eukaryota
ENOG4110P8V LUCA
GeneTreeiENSGT00760000119187
HOGENOMiHOG000233417
HOVERGENiHBG007922
InParanoidiP11465
KOiK06500
OMAiINEGDEY
OrthoDBiEOG091G0AMM
PhylomeDBiP11465
TreeFamiTF336859

Enzyme and pathway databases

ReactomeiR-HSA-202733 Cell surface interactions at the vascular wall

Miscellaneous databases

GeneWikiiPSG2
GenomeRNAii5670
PROiPR:P11465
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000242221 Expressed in 56 organ(s), highest expression level in placenta
CleanExiHS_PSG2
ExpressionAtlasiP11465 baseline and differential
GenevisibleiP11465 HS

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF13895 Ig_2, 1 hit
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPSG2_HUMAN
AccessioniPrimary (citable) accession number: P11465
Secondary accession number(s): Q8TCD9, Q9UEA4, Q9UQ78
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: June 13, 2006
Last modified: November 7, 2018
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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