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Protein

Pregnancy-specific beta-1-glycoprotein 1

Gene

PSG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • female pregnancy Source: ProtInc
  • leukocyte migration Source: Reactome

Enzyme and pathway databases

ReactomeiR-HSA-202733 Cell surface interactions at the vascular wall

Names & Taxonomyi

Protein namesi
Recommended name:
Pregnancy-specific beta-1-glycoprotein 1
Short name:
PS-beta-G-1
Short name:
PSBG-1
Short name:
Pregnancy-specific glycoprotein 1
Alternative name(s):
CD66 antigen-like family member F
Fetal liver non-specific cross-reactive antigen 1/2
Short name:
FL-NCA-1/2
PSG95
Pregnancy-specific beta-1 glycoprotein C/D
Short name:
PS-beta-C/D
CD_antigen: CD66f
Gene namesi
Name:PSG1
Synonyms:B1G1, PSBG1, PSGGA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000231924.9
HGNCiHGNC:9514 PSG1
MIMi176390 gene
neXtProtiNX_P11464

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi5669
OpenTargetsiENSG00000231924
PharmGKBiPA33861

Polymorphism and mutation databases

BioMutaiPSG1
DMDMi129661

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Add BLAST34
ChainiPRO_000001490835 – 419Pregnancy-specific beta-1-glycoprotein 1Add BLAST385

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi61N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi111N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi169 ↔ 217Curated
Glycosylationi199N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi259N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi262 ↔ 310Curated
Glycosylationi268N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi303N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi354 ↔ 394Curated

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP11464
PaxDbiP11464
PeptideAtlasiP11464
PRIDEiP11464
ProteomicsDBi52775
52776 [P11464-2]
52777 [P11464-3]
52778 [P11464-4]

PTM databases

iPTMnetiP11464
PhosphoSitePlusiP11464

Expressioni

Developmental stagei

PSBG are produced in high quantity during pregnancy.

Gene expression databases

BgeeiENSG00000231924 Expressed in 66 organ(s), highest expression level in placenta
ExpressionAtlasiP11464 baseline and differential
GenevisibleiP11464 HS

Organism-specific databases

HPAiHPA046327

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi111644, 49 interactors
IntActiP11464, 4 interactors
STRINGi9606.ENSP00000244296

Structurei

3D structure databases

ProteinModelPortaliP11464
SMRiP11464
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 144Ig-like V-typeAdd BLAST110
Domaini149 – 234Ig-like C2-type 1Add BLAST86
Domaini240 – 327Ig-like C2-type 2Add BLAST88
Domaini335 – 410Ig-like C2-type 3Add BLAST76

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410JG1N Eukaryota
ENOG410YTW2 LUCA
GeneTreeiENSGT00760000119187
HOVERGENiHBG007922
InParanoidiP11464
KOiK06500
OMAiPRKATET
OrthoDBiEOG091G04T1
PhylomeDBiP11464
TreeFamiTF336859

Family and domain databases

Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF13895 Ig_2, 2 hits
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 4 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 4 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits

Sequences (4+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P11464-1) [UniParc]FASTAAdd to basket
Also known as: PSG-1a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGTLSAPPCT QRIKWKGLLL TASLLNFWNL PTTAQVTIEA EPTKVSEGKD
60 70 80 90 100
VLLLVHNLPQ NLTGYIWYKG QMRDLYHYIT SYVVDGEIII YGPAYSGRET
110 120 130 140 150
AYSNASLLIQ NVTREDAGSY TLHIIKGDDG TRGVTGRFTF TLHLETPKPS
160 170 180 190 200
ISSSNLNPRE TMEAVSLTCD PETPDASYLW WMNGQSLPMT HSLKLSETNR
210 220 230 240 250
TLFLLGVTKY TAGPYECEIR NPVSASRSDP VTLNLLPKLP KPYITINNLN
260 270 280 290 300
PRENKDVLNF TCEPKSENYT YIWWLNGQSL PVSPRVKRPI ENRILILPSV
310 320 330 340 350
TRNETGPYQC EIRDRYGGIR SDPVTLNVLY GPDLPRIYPS FTYYRSGEVL
360 370 380 390 400
YLSCSADSNP PAQYSWTINE KFQLPGQKLF IRHITTKHSG LYVCSVRNSA
410
TGKESSKSMT VEVSDWTVP
Length:419
Mass (Da):47,223
Last modified:October 1, 1989 - v1
Checksum:i5E9855162F0C796D
GO
Isoform 2 (identifier: P11464-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     415-419: DWTVP → AYSSSINYTSGNRN

Show »
Length:428
Mass (Da):48,140
Checksum:i529C21EFDD8C7159
GO
Isoform 3 (identifier: P11464-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     415-419: DWTVP → EAL

Show »
Length:417
Mass (Da):46,937
Checksum:iB3888EBC796D37BB
GO
Isoform 4 (identifier: P11464-4) [UniParc]FASTAAdd to basket
Also known as: PSG-1d

The sequence of this isoform differs from the canonical sequence as follows:
     415-419: DWTVP → GKWIPASLAIGF

Show »
Length:426
Mass (Da):47,866
Checksum:iBF98CAAD8338DD1E
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E9F7G5E9F7_HUMAN
Pregnancy specific beta-1-glycoprot...
PSG1 hCG_1995688
326Annotation score:
M0R235M0R235_HUMAN
Pregnancy specific beta-1-glycoprot...
PSG1 hCG_1995688
324Annotation score:
M0QZQ1M0QZQ1_HUMAN
Pregnancy-specific beta-1-glycoprot...
PSG1
242Annotation score:
M0QY44M0QY44_HUMAN
Pregnancy-specific beta-1-glycoprot...
PSG1
154Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti41 – 43EPT → QPP (PubMed:2783133).Curated3
Sequence conflicti41 – 43EPT → QPP (PubMed:2377620).Curated3
Sequence conflicti41 – 43EPT → QPP (PubMed:3257488).Curated3
Sequence conflicti319I → V (PubMed:2377620).Curated1
Sequence conflicti319I → V (PubMed:3257488).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05606341E → Q. Corresponds to variant dbSNP:rs707744Ensembl.1
Natural variantiVAR_05606443T → P. Corresponds to variant dbSNP:rs707745Ensembl.1
Natural variantiVAR_05606547E → K. Corresponds to variant dbSNP:rs1058956Ensembl.1
Natural variantiVAR_05606663T → A. Corresponds to variant dbSNP:rs1064479Ensembl.1
Natural variantiVAR_05606773R → K. Corresponds to variant dbSNP:rs1064480Ensembl.1
Natural variantiVAR_05606887E → Q. Corresponds to variant dbSNP:rs1058661Ensembl.1
Natural variantiVAR_056069101A → V. Corresponds to variant dbSNP:rs707748Ensembl.1
Natural variantiVAR_059408125I → V. Corresponds to variant dbSNP:rs1058960Ensembl.1
Natural variantiVAR_056070134V → E. Corresponds to variant dbSNP:rs1058671Ensembl.1
Natural variantiVAR_056071197E → K. Corresponds to variant dbSNP:rs1058692Ensembl.1
Natural variantiVAR_056072198T → N. Corresponds to variant dbSNP:rs1058693Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_002550415 – 419DWTVP → AYSSSINYTSGNRN in isoform 2. 1 Publication5
Alternative sequenceiVSP_002549415 – 419DWTVP → EAL in isoform 3. 1 Publication5
Alternative sequenceiVSP_002548415 – 419DWTVP → GKWIPASLAIGF in isoform 4. 6 Publications5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20881 mRNA Translation: AAA52603.1
M20879 mRNA Translation: AAA52602.1
M21822 mRNA Translation: AAA52601.1
M25385 mRNA Translation: AAA36513.1
M34715 mRNA Translation: AAA36511.1
M17908 mRNA Translation: AAA52590.1
M17909 mRNA Translation: AAA52591.1
M33663 mRNA Translation: AAA36517.1
M33664 mRNA Translation: AAA36515.1
J04539 mRNA Translation: AAA60204.1
M37397 mRNA Translation: AAA60960.1
CR450329 mRNA Translation: CAG29325.1
AC005238 Genomic DNA Translation: AAC25488.1
AC005238 Genomic DNA Translation: AAC25489.1
AC005238 Genomic DNA Translation: AAC25490.1
CH471126 Genomic DNA Translation: EAW57156.1
BC022338 mRNA Translation: AAH22338.1
BC058285 mRNA Translation: AAH58285.1
AH007517 Genomic DNA Translation: AAD21020.1
CCDSiCCDS12612.1 [P11464-4]
CCDS54275.1 [P11464-1]
CCDS59392.1 [P11464-3]
CCDS74380.1 [P11464-2]
PIRiA27658
A28277
A33258
A35341
A35964
B33258
C43354
D43354
E32268 A31135
E43354
RefSeqiNP_001171754.1, NM_001184825.1 [P11464-1]
NP_001171755.1, NM_001184826.1 [P11464-3]
NP_001284702.1, NM_001297773.1 [P11464-2]
NP_008836.2, NM_006905.2 [P11464-4]
UniGeneiHs.709192

Genome annotation databases

EnsembliENST00000244296; ENSP00000244296; ENSG00000231924 [P11464-4]
ENST00000312439; ENSP00000308970; ENSG00000231924 [P11464-2]
ENST00000436291; ENSP00000413041; ENSG00000231924 [P11464-1]
ENST00000595356; ENSP00000472610; ENSG00000231924 [P11464-3]
GeneIDi5669
KEGGihsa:5669
UCSCiuc002ouz.3 human [P11464-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20881 mRNA Translation: AAA52603.1
M20879 mRNA Translation: AAA52602.1
M21822 mRNA Translation: AAA52601.1
M25385 mRNA Translation: AAA36513.1
M34715 mRNA Translation: AAA36511.1
M17908 mRNA Translation: AAA52590.1
M17909 mRNA Translation: AAA52591.1
M33663 mRNA Translation: AAA36517.1
M33664 mRNA Translation: AAA36515.1
J04539 mRNA Translation: AAA60204.1
M37397 mRNA Translation: AAA60960.1
CR450329 mRNA Translation: CAG29325.1
AC005238 Genomic DNA Translation: AAC25488.1
AC005238 Genomic DNA Translation: AAC25489.1
AC005238 Genomic DNA Translation: AAC25490.1
CH471126 Genomic DNA Translation: EAW57156.1
BC022338 mRNA Translation: AAH22338.1
BC058285 mRNA Translation: AAH58285.1
AH007517 Genomic DNA Translation: AAD21020.1
CCDSiCCDS12612.1 [P11464-4]
CCDS54275.1 [P11464-1]
CCDS59392.1 [P11464-3]
CCDS74380.1 [P11464-2]
PIRiA27658
A28277
A33258
A35341
A35964
B33258
C43354
D43354
E32268 A31135
E43354
RefSeqiNP_001171754.1, NM_001184825.1 [P11464-1]
NP_001171755.1, NM_001184826.1 [P11464-3]
NP_001284702.1, NM_001297773.1 [P11464-2]
NP_008836.2, NM_006905.2 [P11464-4]
UniGeneiHs.709192

3D structure databases

ProteinModelPortaliP11464
SMRiP11464
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111644, 49 interactors
IntActiP11464, 4 interactors
STRINGi9606.ENSP00000244296

PTM databases

iPTMnetiP11464
PhosphoSitePlusiP11464

Polymorphism and mutation databases

BioMutaiPSG1
DMDMi129661

Proteomic databases

MaxQBiP11464
PaxDbiP11464
PeptideAtlasiP11464
PRIDEiP11464
ProteomicsDBi52775
52776 [P11464-2]
52777 [P11464-3]
52778 [P11464-4]

Protocols and materials databases

DNASUi5669
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000244296; ENSP00000244296; ENSG00000231924 [P11464-4]
ENST00000312439; ENSP00000308970; ENSG00000231924 [P11464-2]
ENST00000436291; ENSP00000413041; ENSG00000231924 [P11464-1]
ENST00000595356; ENSP00000472610; ENSG00000231924 [P11464-3]
GeneIDi5669
KEGGihsa:5669
UCSCiuc002ouz.3 human [P11464-1]

Organism-specific databases

CTDi5669
DisGeNETi5669
EuPathDBiHostDB:ENSG00000231924.9
GeneCardsiPSG1
HGNCiHGNC:9514 PSG1
HPAiHPA046327
MIMi176390 gene
neXtProtiNX_P11464
OpenTargetsiENSG00000231924
PharmGKBiPA33861
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JG1N Eukaryota
ENOG410YTW2 LUCA
GeneTreeiENSGT00760000119187
HOVERGENiHBG007922
InParanoidiP11464
KOiK06500
OMAiPRKATET
OrthoDBiEOG091G04T1
PhylomeDBiP11464
TreeFamiTF336859

Enzyme and pathway databases

ReactomeiR-HSA-202733 Cell surface interactions at the vascular wall

Miscellaneous databases

GeneWikiiPSG1_(gene)
GenomeRNAii5669
PROiPR:P11464
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000231924 Expressed in 66 organ(s), highest expression level in placenta
ExpressionAtlasiP11464 baseline and differential
GenevisibleiP11464 HS

Family and domain databases

Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF13895 Ig_2, 2 hits
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 4 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 4 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPSG1_HUMAN
AccessioniPrimary (citable) accession number: P11464
Secondary accession number(s): O75236
, P11462, P11463, Q15231, Q15241, Q15243, Q16660, Q6ICR4, Q9P1W5, Q9UQ79
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: November 7, 2018
This is version 178 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  6. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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Main funding by: National Institutes of Health

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