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Protein

Pregnancy-specific beta-1-glycoprotein 1

Gene

PSG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • female pregnancy Source: ProtInc
  • leukocyte migration Source: Reactome

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-202733 Cell surface interactions at the vascular wall

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pregnancy-specific beta-1-glycoprotein 1
Short name:
PS-beta-G-1
Short name:
PSBG-1
Short name:
Pregnancy-specific glycoprotein 1
Alternative name(s):
CD66 antigen-like family member F
Fetal liver non-specific cross-reactive antigen 1/2
Short name:
FL-NCA-1/2
PSG95
Pregnancy-specific beta-1 glycoprotein C/D
Short name:
PS-beta-C/D
CD_antigen: CD66f
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PSG1
Synonyms:B1G1, PSBG1, PSGGA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000231924.9

Human Gene Nomenclature Database

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HGNCi
HGNC:9514 PSG1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
176390 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P11464

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
5669

Open Targets

More...
OpenTargetsi
ENSG00000231924

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33861

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PSG1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
129661

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 34Add BLAST34
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001490835 – 419Pregnancy-specific beta-1-glycoprotein 1Add BLAST385

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi61N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi111N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi169 ↔ 217Curated
Glycosylationi199N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi259N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi262 ↔ 310Curated
Glycosylationi268N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi303N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi354 ↔ 394Curated

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P11464

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P11464

PeptideAtlas

More...
PeptideAtlasi
P11464

PRoteomics IDEntifications database

More...
PRIDEi
P11464

ProteomicsDB human proteome resource

More...
ProteomicsDBi
52775
52776 [P11464-2]
52777 [P11464-3]
52778 [P11464-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P11464

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P11464

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

PSBG are produced in high quantity during pregnancy.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000231924 Expressed in 66 organ(s), highest expression level in placenta

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P11464 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P11464 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA046327

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111644, 49 interactors

Protein interaction database and analysis system

More...
IntActi
P11464, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000244296

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P11464

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P11464

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini35 – 144Ig-like V-typeAdd BLAST110
Domaini149 – 234Ig-like C2-type 1Add BLAST86
Domaini240 – 327Ig-like C2-type 2Add BLAST88
Domaini335 – 410Ig-like C2-type 3Add BLAST76

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410JG1N Eukaryota
ENOG410YTW2 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153087

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG007922

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P11464

KEGG Orthology (KO)

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KOi
K06500

Identification of Orthologs from Complete Genome Data

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OMAi
PRKATET

Database of Orthologous Groups

More...
OrthoDBi
EOG091G04T1

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P11464

TreeFam database of animal gene trees

More...
TreeFami
TF336859

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13895 Ig_2, 2 hits
PF07686 V-set, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409 IG, 4 hits
SM00408 IGc2, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P11464-1) [UniParc]FASTAAdd to basket
Also known as: PSG-1a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGTLSAPPCT QRIKWKGLLL TASLLNFWNL PTTAQVTIEA EPTKVSEGKD
60 70 80 90 100
VLLLVHNLPQ NLTGYIWYKG QMRDLYHYIT SYVVDGEIII YGPAYSGRET
110 120 130 140 150
AYSNASLLIQ NVTREDAGSY TLHIIKGDDG TRGVTGRFTF TLHLETPKPS
160 170 180 190 200
ISSSNLNPRE TMEAVSLTCD PETPDASYLW WMNGQSLPMT HSLKLSETNR
210 220 230 240 250
TLFLLGVTKY TAGPYECEIR NPVSASRSDP VTLNLLPKLP KPYITINNLN
260 270 280 290 300
PRENKDVLNF TCEPKSENYT YIWWLNGQSL PVSPRVKRPI ENRILILPSV
310 320 330 340 350
TRNETGPYQC EIRDRYGGIR SDPVTLNVLY GPDLPRIYPS FTYYRSGEVL
360 370 380 390 400
YLSCSADSNP PAQYSWTINE KFQLPGQKLF IRHITTKHSG LYVCSVRNSA
410
TGKESSKSMT VEVSDWTVP
Length:419
Mass (Da):47,223
Last modified:October 1, 1989 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5E9855162F0C796D
GO
Isoform 2 (identifier: P11464-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     415-419: DWTVP → AYSSSINYTSGNRN

Show »
Length:428
Mass (Da):48,140
Checksum:i529C21EFDD8C7159
GO
Isoform 3 (identifier: P11464-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     415-419: DWTVP → EAL

Show »
Length:417
Mass (Da):46,937
Checksum:iB3888EBC796D37BB
GO
Isoform 4 (identifier: P11464-4) [UniParc]FASTAAdd to basket
Also known as: PSG-1d

The sequence of this isoform differs from the canonical sequence as follows:
     415-419: DWTVP → GKWIPASLAIGF

Show »
Length:426
Mass (Da):47,866
Checksum:iBF98CAAD8338DD1E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E9F7G5E9F7_HUMAN
Pregnancy specific beta-1-glycoprot...
PSG1 hCG_1995688
326Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R235M0R235_HUMAN
Pregnancy specific beta-1-glycoprot...
PSG1 hCG_1995688
324Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZQ1M0QZQ1_HUMAN
Pregnancy-specific beta-1-glycoprot...
PSG1
242Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QY44M0QY44_HUMAN
Pregnancy-specific beta-1-glycoprot...
PSG1
154Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti41 – 43EPT → QPP (PubMed:2783133).Curated3
Sequence conflicti41 – 43EPT → QPP (PubMed:2377620).Curated3
Sequence conflicti41 – 43EPT → QPP (PubMed:3257488).Curated3
Sequence conflicti319I → V (PubMed:2377620).Curated1
Sequence conflicti319I → V (PubMed:3257488).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05606341E → Q. Corresponds to variant dbSNP:rs707744Ensembl.1
Natural variantiVAR_05606443T → P. Corresponds to variant dbSNP:rs707745Ensembl.1
Natural variantiVAR_05606547E → K. Corresponds to variant dbSNP:rs1058956Ensembl.1
Natural variantiVAR_05606663T → A. Corresponds to variant dbSNP:rs1064479Ensembl.1
Natural variantiVAR_05606773R → K. Corresponds to variant dbSNP:rs1064480Ensembl.1
Natural variantiVAR_05606887E → Q. Corresponds to variant dbSNP:rs1058661Ensembl.1
Natural variantiVAR_056069101A → V. Corresponds to variant dbSNP:rs707748Ensembl.1
Natural variantiVAR_059408125I → V. Corresponds to variant dbSNP:rs1058960Ensembl.1
Natural variantiVAR_056070134V → E. Corresponds to variant dbSNP:rs1058671Ensembl.1
Natural variantiVAR_056071197E → K. Corresponds to variant dbSNP:rs1058692Ensembl.1
Natural variantiVAR_056072198T → N. Corresponds to variant dbSNP:rs1058693Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_002550415 – 419DWTVP → AYSSSINYTSGNRN in isoform 2. 1 Publication5
Alternative sequenceiVSP_002549415 – 419DWTVP → EAL in isoform 3. 1 Publication5
Alternative sequenceiVSP_002548415 – 419DWTVP → GKWIPASLAIGF in isoform 4. 6 Publications5

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M20881 mRNA Translation: AAA52603.1
M20879 mRNA Translation: AAA52602.1
M21822 mRNA Translation: AAA52601.1
M25385 mRNA Translation: AAA36513.1
M34715 mRNA Translation: AAA36511.1
M17908 mRNA Translation: AAA52590.1
M17909 mRNA Translation: AAA52591.1
M33663 mRNA Translation: AAA36517.1
M33664 mRNA Translation: AAA36515.1
J04539 mRNA Translation: AAA60204.1
M37397 mRNA Translation: AAA60960.1
CR450329 mRNA Translation: CAG29325.1
AC005238 Genomic DNA Translation: AAC25488.1
AC005238 Genomic DNA Translation: AAC25489.1
AC005238 Genomic DNA Translation: AAC25490.1
CH471126 Genomic DNA Translation: EAW57156.1
BC022338 mRNA Translation: AAH22338.1
BC058285 mRNA Translation: AAH58285.1
AH007517 Genomic DNA Translation: AAD21020.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12612.1 [P11464-4]
CCDS54275.1 [P11464-1]
CCDS59392.1 [P11464-3]
CCDS74380.1 [P11464-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
A27658
A28277
A33258
A35341
A35964
B33258
C43354
D43354
E32268 A31135
E43354

NCBI Reference Sequences

More...
RefSeqi
NP_001171754.1, NM_001184825.1 [P11464-1]
NP_001171755.1, NM_001184826.1 [P11464-3]
NP_001284702.1, NM_001297773.1 [P11464-2]
NP_008836.2, NM_006905.2 [P11464-4]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.709192

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000244296; ENSP00000244296; ENSG00000231924 [P11464-4]
ENST00000312439; ENSP00000308970; ENSG00000231924 [P11464-2]
ENST00000436291; ENSP00000413041; ENSG00000231924 [P11464-1]
ENST00000595356; ENSP00000472610; ENSG00000231924 [P11464-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
5669

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:5669

UCSC genome browser

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UCSCi
uc002ouz.3 human [P11464-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20881 mRNA Translation: AAA52603.1
M20879 mRNA Translation: AAA52602.1
M21822 mRNA Translation: AAA52601.1
M25385 mRNA Translation: AAA36513.1
M34715 mRNA Translation: AAA36511.1
M17908 mRNA Translation: AAA52590.1
M17909 mRNA Translation: AAA52591.1
M33663 mRNA Translation: AAA36517.1
M33664 mRNA Translation: AAA36515.1
J04539 mRNA Translation: AAA60204.1
M37397 mRNA Translation: AAA60960.1
CR450329 mRNA Translation: CAG29325.1
AC005238 Genomic DNA Translation: AAC25488.1
AC005238 Genomic DNA Translation: AAC25489.1
AC005238 Genomic DNA Translation: AAC25490.1
CH471126 Genomic DNA Translation: EAW57156.1
BC022338 mRNA Translation: AAH22338.1
BC058285 mRNA Translation: AAH58285.1
AH007517 Genomic DNA Translation: AAD21020.1
CCDSiCCDS12612.1 [P11464-4]
CCDS54275.1 [P11464-1]
CCDS59392.1 [P11464-3]
CCDS74380.1 [P11464-2]
PIRiA27658
A28277
A33258
A35341
A35964
B33258
C43354
D43354
E32268 A31135
E43354
RefSeqiNP_001171754.1, NM_001184825.1 [P11464-1]
NP_001171755.1, NM_001184826.1 [P11464-3]
NP_001284702.1, NM_001297773.1 [P11464-2]
NP_008836.2, NM_006905.2 [P11464-4]
UniGeneiHs.709192

3D structure databases

ProteinModelPortaliP11464
SMRiP11464
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111644, 49 interactors
IntActiP11464, 4 interactors
STRINGi9606.ENSP00000244296

PTM databases

iPTMnetiP11464
PhosphoSitePlusiP11464

Polymorphism and mutation databases

BioMutaiPSG1
DMDMi129661

Proteomic databases

MaxQBiP11464
PaxDbiP11464
PeptideAtlasiP11464
PRIDEiP11464
ProteomicsDBi52775
52776 [P11464-2]
52777 [P11464-3]
52778 [P11464-4]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
5669
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000244296; ENSP00000244296; ENSG00000231924 [P11464-4]
ENST00000312439; ENSP00000308970; ENSG00000231924 [P11464-2]
ENST00000436291; ENSP00000413041; ENSG00000231924 [P11464-1]
ENST00000595356; ENSP00000472610; ENSG00000231924 [P11464-3]
GeneIDi5669
KEGGihsa:5669
UCSCiuc002ouz.3 human [P11464-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
5669
DisGeNETi5669
EuPathDBiHostDB:ENSG00000231924.9

GeneCards: human genes, protein and diseases

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GeneCardsi
PSG1
HGNCiHGNC:9514 PSG1
HPAiHPA046327
MIMi176390 gene
neXtProtiNX_P11464
OpenTargetsiENSG00000231924
PharmGKBiPA33861

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410JG1N Eukaryota
ENOG410YTW2 LUCA
GeneTreeiENSGT00940000153087
HOVERGENiHBG007922
InParanoidiP11464
KOiK06500
OMAiPRKATET
OrthoDBiEOG091G04T1
PhylomeDBiP11464
TreeFamiTF336859

Enzyme and pathway databases

ReactomeiR-HSA-202733 Cell surface interactions at the vascular wall

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PSG1_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
5669

Protein Ontology

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PROi
PR:P11464

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000231924 Expressed in 66 organ(s), highest expression level in placenta
ExpressionAtlasiP11464 baseline and differential
GenevisibleiP11464 HS

Family and domain databases

Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF13895 Ig_2, 2 hits
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 4 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 4 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPSG1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P11464
Secondary accession number(s): O75236
, P11462, P11463, Q15231, Q15241, Q15243, Q16660, Q6ICR4, Q9P1W5, Q9UQ79
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: December 5, 2018
This is version 179 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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