UniProtKB - P11446 (ARGC_ECOLI)
Protein
N-acetyl-gamma-glutamyl-phosphate reductase
Gene
argC
Organism
Escherichia coli (strain K12)
Status
Functioni
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.UniRule annotation1 Publication
Catalytic activityi
- N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = H+ + N-acetyl-L-glutamyl 5-phosphate + NADPHUniRule annotation1 PublicationEC:1.2.1.38UniRule annotation1 Publication
: L-arginine biosynthesis Pathwayi
This protein is involved in step 3 of the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate.UniRule annotation1 PublicationProteins known to be involved in the 4 steps of the subpathway in this organism are:
- Amino-acid acetyltransferase (argA), Amino-acid acetyltransferase (argA)
- Acetylglutamate kinase (argB), Acetylglutamate kinase (argB)
- N-acetyl-gamma-glutamyl-phosphate reductase (argC), N-acetyl-gamma-glutamyl-phosphate reductase (argC)
- Acetylornithine/succinyldiaminopimelate aminotransferase (argD), Acetylornithine/succinyldiaminopimelate aminotransferase (argD)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 154 | UniRule annotation | 1 |
GO - Molecular functioni
- N-acetyl-gamma-glutamyl-phosphate reductase activity Source: EcoCyc
- NAD binding Source: InterPro
- protein dimerization activity Source: InterPro
GO - Biological processi
- arginine biosynthetic process Source: EcoCyc
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Amino-acid biosynthesis, Arginine biosynthesis |
Ligand | NADP |
Enzyme and pathway databases
BioCyci | EcoCyc:N-ACETYLGLUTPREDUCT-MONOMER MetaCyc:N-ACETYLGLUTPREDUCT-MONOMER |
BRENDAi | 1.2.1.38, 2026 |
UniPathwayi | UPA00068;UER00108 |
Names & Taxonomyi
Protein namesi | Recommended name: N-acetyl-gamma-glutamyl-phosphate reductaseUniRule annotationCurated (EC:1.2.1.38UniRule annotation1 Publication)Short name: AGPRUniRule annotationCurated Alternative name(s): N-acetyl-glutamate semialdehyde dehydrogenase1 PublicationUniRule annotation Short name: NAGSA dehydrogenase1 PublicationUniRule annotation |
Gene namesi | Name:argCUniRule annotation Ordered Locus Names:b3958, JW3930 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm UniRule annotation
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000112401 | 1 – 334 | N-acetyl-gamma-glutamyl-phosphate reductaseAdd BLAST | 334 |
Proteomic databases
PaxDbi | P11446 |
PRIDEi | P11446 |
Interactioni
GO - Molecular functioni
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
BioGRIDi | 4262190, 6 interactors 852751, 1 interactor |
IntActi | P11446, 1 interactor |
STRINGi | 511145.b3958 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG0002, Bacteria |
HOGENOMi | CLU_006384_0_1_6 |
InParanoidi | P11446 |
PhylomeDBi | P11446 |
Family and domain databases
HAMAPi | MF_00150, ArgC_type1, 1 hit |
InterProi | View protein in InterPro IPR023013, AGPR_AS IPR000706, AGPR_type-1 IPR036291, NAD(P)-bd_dom_sf IPR000534, Semialdehyde_DH_NAD-bd IPR012280, Semialdhyde_DH_dimer_dom |
Pfami | View protein in Pfam PF01118, Semialdhyde_dh, 1 hit PF02774, Semialdhyde_dhC, 1 hit |
SMARTi | View protein in SMART SM00859, Semialdhyde_dh, 1 hit |
SUPFAMi | SSF51735, SSF51735, 1 hit |
TIGRFAMsi | TIGR01850, argC, 1 hit |
PROSITEi | View protein in PROSITE PS01224, ARGC, 1 hit |
i Sequence
Sequence statusi: Complete.
P11446-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLNTLIVGAS GYAGAELVTY VNRHPHMNIT ALTVSAQSND AGKLISDLHP
60 70 80 90 100
QLKGIVDLPL QPMSDISEFS PGVDVVFLAT AHEVSHDLAP QFLEAGCVVF
110 120 130 140 150
DLSGAFRVND ATFYEKYYGF THQYPELLEQ AAYGLAEWCG NKLKEANLIA
160 170 180 190 200
VPGCYPTAAQ LALKPLIDAD LLDLNQWPVI NATSGVSGAG RKAAISNSFC
210 220 230 240 250
EVSLQPYGVF THRHQPEIAT HLGADVIFTP HLGNFPRGIL ETITCRLKSG
260 270 280 290 300
VTQAQVAQVL QQAYAHKPLV RLYDKGVPAL KNVVGLPFCD IGFAVQGEHL
310 320 330
IIVATEDNLL KGAAAQAVQC ANIRFGYAET QSLI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M21446 Genomic DNA Translation: AAA23477.1 U00006 Genomic DNA Translation: AAC43064.1 U00096 Genomic DNA Translation: AAC76940.1 AP009048 Genomic DNA Translation: BAE77353.1 J01587 Genomic DNA Translation: AAB59146.1 X55417 Genomic DNA No translation available. |
PIRi | JT0332, RDECEP |
RefSeqi | NP_418393.1, NC_000913.3 WP_000935370.1, NZ_STEB01000037.1 |
Genome annotation databases
EnsemblBacteriai | AAC76940; AAC76940; b3958 BAE77353; BAE77353; BAE77353 |
GeneIDi | 57732202 948455 |
KEGGi | ecj:JW3930 eco:b3958 |
PATRICi | fig|1411691.4.peg.2747 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M21446 Genomic DNA Translation: AAA23477.1 U00006 Genomic DNA Translation: AAC43064.1 U00096 Genomic DNA Translation: AAC76940.1 AP009048 Genomic DNA Translation: BAE77353.1 J01587 Genomic DNA Translation: AAB59146.1 X55417 Genomic DNA No translation available. |
PIRi | JT0332, RDECEP |
RefSeqi | NP_418393.1, NC_000913.3 WP_000935370.1, NZ_STEB01000037.1 |
3D structure databases
SMRi | P11446 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4262190, 6 interactors 852751, 1 interactor |
IntActi | P11446, 1 interactor |
STRINGi | 511145.b3958 |
Proteomic databases
PaxDbi | P11446 |
PRIDEi | P11446 |
Genome annotation databases
EnsemblBacteriai | AAC76940; AAC76940; b3958 BAE77353; BAE77353; BAE77353 |
GeneIDi | 57732202 948455 |
KEGGi | ecj:JW3930 eco:b3958 |
PATRICi | fig|1411691.4.peg.2747 |
Organism-specific databases
EchoBASEi | EB0063 |
Phylogenomic databases
eggNOGi | COG0002, Bacteria |
HOGENOMi | CLU_006384_0_1_6 |
InParanoidi | P11446 |
PhylomeDBi | P11446 |
Enzyme and pathway databases
UniPathwayi | UPA00068;UER00108 |
BioCyci | EcoCyc:N-ACETYLGLUTPREDUCT-MONOMER MetaCyc:N-ACETYLGLUTPREDUCT-MONOMER |
BRENDAi | 1.2.1.38, 2026 |
Miscellaneous databases
PROi | PR:P11446 |
Family and domain databases
HAMAPi | MF_00150, ArgC_type1, 1 hit |
InterProi | View protein in InterPro IPR023013, AGPR_AS IPR000706, AGPR_type-1 IPR036291, NAD(P)-bd_dom_sf IPR000534, Semialdehyde_DH_NAD-bd IPR012280, Semialdhyde_DH_dimer_dom |
Pfami | View protein in Pfam PF01118, Semialdhyde_dh, 1 hit PF02774, Semialdhyde_dhC, 1 hit |
SMARTi | View protein in SMART SM00859, Semialdhyde_dh, 1 hit |
SUPFAMi | SSF51735, SSF51735, 1 hit |
TIGRFAMsi | TIGR01850, argC, 1 hit |
PROSITEi | View protein in PROSITE PS01224, ARGC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ARGC_ECOLI | |
Accessioni | P11446Primary (citable) accession number: P11446 Secondary accession number(s): Q2M8Q3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1989 |
Last sequence update: | October 1, 1989 | |
Last modified: | February 10, 2021 | |
This is version 169 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families