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UniProtKB - P11442 (CLH1_RAT)

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Protein

Clathrin heavy chain 1

Gene

Cltc

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network (By similarity). Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577,PubMed:16968737). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (By similarity). Plays a role in early autophagosome formation (By similarity).By similarity2 Publications

GO - Molecular functioni

  • ankyrin binding Source: RGD
  • clathrin light chain binding Source: InterPro
  • heat shock protein binding Source: RGD
  • peptide binding Source: RGD
  • protein C-terminus binding Source: RGD
  • structural molecule activity Source: InterPro
View the complete GO annotation on QuickGO ...

GO - Biological processi

  • autophagy Source: UniProtKB-KW
  • clathrin coat assembly Source: InterPro
  • Golgi organization Source: RGD
  • intracellular protein transport Source: InterPro
  • mitotic cell cycle Source: UniProtKB
  • negative regulation of hyaluronan biosynthetic process Source: UniProtKB
  • receptor-mediated endocytosis Source: UniProtKB
View the complete GO annotation on QuickGO ...

Keywordsi

Biological processAutophagy

Names & Taxonomyi

Protein namesi
Recommended name:
Clathrin heavy chain 1
Gene namesi
Name:Cltc
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2364 Cltc

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Coated pit, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00002057802 – 1675Clathrin heavy chain 1Add BLAST1674

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1
Modified residuei67PhosphoserineBy similarity1
Modified residuei105PhosphothreonineCombined sources1
Modified residuei184PhosphotyrosineBy similarity1
Modified residuei394PhosphothreonineCombined sources1
Modified residuei634PhosphotyrosineBy similarity1
Modified residuei737N6-succinyllysineBy similarity1
Modified residuei856N6-acetyllysineBy similarity1
Modified residuei899PhosphotyrosineBy similarity1
Modified residuei1167PhosphoserineBy similarity1
Modified residuei1206PhosphotyrosineBy similarity1
Modified residuei1229PhosphoserineBy similarity1
Modified residuei1441N6-acetyllysine; alternateBy similarity1
Modified residuei1441N6-succinyllysine; alternateBy similarity1
Modified residuei1477PhosphotyrosineBy similarity1
Modified residuei1487PhosphotyrosineBy similarity1
Modified residuei1494PhosphoserineCombined sources1
Modified residuei1501N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP11442
PRIDEiP11442

2D gel databases

World-2DPAGEi0004:P11442

PTM databases

iPTMnetiP11442
PhosphoSitePlusiP11442

Interactioni

Subunit structurei

Clathrin triskelions, composed of 3 heavy chains and 3 light chains, are the basic subunits of the clathrin coat (PubMed:16968737). In the presence of light chains, hub assembly is influenced by both the pH and the concentration of calcium (By similarity). Interacts with HIP1 (By similarity). Interacts with DENND1A, DENND1B and DENND1C (By similarity). Interacts with OCRL (By similarity). Interacts with ERBB2 (By similarity). Interacts with FKBP6 (By similarity). Interacts with CKAP5 and TACC3 forming the TACC3/ch-TOG/clathrin complex located at spindle inter-microtubules bridges; the complex implicates clathrin triskelions; TACC3 and CLTC are proposed to form a composite microtubule interaction surface (By similarity). Interacts with ATG16L1 (via N-terminus) (By similarity). Interacts with RFTN1; the interaction occurs in response to pathogens (By similarity). Interacts with USP2 isoform 2 (By similarity).By similarity1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • ankyrin binding Source: RGD
  • clathrin light chain binding Source: InterPro
  • heat shock protein binding Source: RGD
  • protein C-terminus binding Source: RGD
View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi248464, 13 interactors
CORUMiP11442
DIPiDIP-36966N
IntActiP11442, 10 interactors
MINTiP11442
STRINGi10116.ENSRNOP00000005987

Structurei

Secondary structure

11675
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 14Combined sources8
Helixi15 – 18Combined sources4
Helixi22 – 24Combined sources3
Turni27 – 29Combined sources3
Beta strandi30 – 34Combined sources5
Beta strandi37 – 42Combined sources6
Beta strandi49 – 54Combined sources6
Beta strandi62 – 65Combined sources4
Beta strandi71 – 73Combined sources3
Beta strandi75 – 78Combined sources4
Beta strandi80 – 84Combined sources5
Beta strandi87 – 92Combined sources6
Turni93 – 96Combined sources4
Beta strandi97 – 103Combined sources7
Beta strandi110 – 115Combined sources6
Beta strandi118 – 122Combined sources5
Beta strandi124 – 135Combined sources12
Beta strandi139 – 143Combined sources5
Helixi146 – 148Combined sources3
Beta strandi152 – 158Combined sources7
Beta strandi162 – 173Combined sources12
Beta strandi176 – 186Combined sources11
Beta strandi191 – 194Combined sources4
Beta strandi197 – 205Combined sources9
Beta strandi210 – 220Combined sources11
Beta strandi227 – 232Combined sources6
Beta strandi246 – 249Combined sources4
Beta strandi261 – 267Combined sources7
Turni268 – 271Combined sources4
Beta strandi272 – 277Combined sources6
Beta strandi280 – 286Combined sources7
Turni287 – 289Combined sources3
Beta strandi292 – 297Combined sources6
Beta strandi303 – 309Combined sources7
Turni310 – 313Combined sources4
Beta strandi314 – 319Combined sources6
Turni320 – 322Combined sources3
Beta strandi323 – 329Combined sources7
Turni331 – 333Combined sources3
Helixi334 – 340Combined sources7
Helixi345 – 354Combined sources10
Helixi361 – 373Combined sources13
Helixi377 – 386Combined sources10
Helixi388 – 390Combined sources3
Helixi395 – 401Combined sources7
Helixi413 – 424Combined sources12
Helixi429 – 441Combined sources13
Helixi445 – 454Combined sources10
Helixi461 – 470Combined sources10
Helixi473 – 482Combined sources10

3D structure databases

ProteinModelPortaliP11442
SMRiP11442
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP11442

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati537 – 683CHCR 1Add BLAST147
Repeati686 – 828CHCR 2Add BLAST143
Repeati833 – 972CHCR 3Add BLAST140
Repeati979 – 1124CHCR 4Add BLAST146
Repeati1128 – 1269CHCR 5Add BLAST142
Repeati1274 – 1420CHCR 6Add BLAST147
Repeati1423 – 1566CHCR 7Add BLAST144

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 479Globular terminal domainAdd BLAST478
Regioni24 – 67WD40-like repeat 1Add BLAST44
Regioni68 – 107WD40-like repeat 2Add BLAST40
Regioni108 – 149WD40-like repeat 3Add BLAST42
Regioni150 – 195WD40-like repeat 4Add BLAST46
Regioni196 – 257WD40-like repeat 5Add BLAST62
Regioni258 – 301WD40-like repeat 6Add BLAST44
Regioni302 – 330WD40-like repeat 7Add BLAST29
Regioni449 – 465Binding site for the uncoating ATPase, involved in lattice disassemblySequence analysisAdd BLAST17
Regioni480 – 523Flexible linkerAdd BLAST44
Regioni524 – 1675Heavy chain armAdd BLAST1152
Regioni524 – 634Distal segmentAdd BLAST111
Regioni639 – 1675Proximal segmentAdd BLAST1037
Regioni1213 – 1522Involved in binding clathrin light chainBy similarityAdd BLAST310
Regioni1550 – 1675TrimerizationBy similarityAdd BLAST126

Domaini

The N-terminal seven-bladed beta-propeller is formed by WD40-like repeats, and projects inward from the polyhedral outer clathrin coat. It constitutes a major protein-protein interaction node.

Sequence similaritiesi

Belongs to the clathrin heavy chain family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0985 Eukaryota
ENOG410XPH1 LUCA
HOGENOMiHOG000188877
HOVERGENiHBG005344
InParanoidiP11442
KOiK04646
PhylomeDBiP11442

Family and domain databases

Gene3Di1.25.40.10, 4 hits
2.130.10.110, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR000547 Clathrin_H-chain/VPS_repeat
IPR015348 Clathrin_H-chain_linker_core
IPR016025 Clathrin_H-chain_N
IPR022365 Clathrin_H-chain_propeller_rpt
IPR016341 Clathrin_heavy_chain
IPR011990 TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF00637 Clathrin, 7 hits
PF09268 Clathrin-link, 1 hit
PF01394 Clathrin_propel, 5 hits
PIRSFiPIRSF002290 Clathrin_H_chain, 1 hit
SMARTiView protein in SMART
SM00299 CLH, 7 hits
SUPFAMiSSF48371 SSF48371, 6 hits
SSF50989 SSF50989, 1 hit
PROSITEiView protein in PROSITE
PS50236 CHCR, 7 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11442-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQILPIRFQ EHLQLQNLGI NPANIGFSTL TMESDKFICI REKVGEQAQV 
        60         70         80         90        100
VIIDMNDPSN PIRRPISADS AIMNPASKVI ALKAGKTLQI FNIEMKSKMK 
       110        120        130        140        150
AHTMTDDVTF WKWISLNTVA LVTDNAVYHW SMEGESQPVK MFDRHSSLAG 
       160        170        180        190        200
CQIINYRTDA KQKWLLLTGI SAQQNRVVGA MQLYSVDRKV SQPIEGHAAS 
       210        220        230        240        250
FAQFKMEGNA EESTLFCFAV RGQAGGKLHI IEVGTPPTGN QPFPKKAVDV 
       260        270        280        290        300
FFPPEAQNDF PVAMQISEKH DVVFLITKYG YIHLYDLETG TCIYMNRISG 
       310        320        330        340        350
ETIFVTAPHE ATAGIIGVNR KGQVLSVCVE EENIIPYITN VLQNPDLALR 
       360        370        380        390        400
MAVRNNLAGA EELFARKFNA LFAQGNYSEA AKVAANAPKG ILRTPDTIRR 
       410        420        430        440        450
FQSVPAQPGQ TSPLLQYFGI LLDQGQLNKY ESLELCRPVL QQGRKQLLEK 
       460        470        480        490        500
WLKEDKLECS EELGDLVKSV DPTLALSVYL RANVPNKVIQ CFAETGQVQK 
       510        520        530        540        550
IVLYAKKVGY TPDWIFLLRN VMRISPDQGQ QFAQMLVQDE EPLADITQIV 
       560        570        580        590        600
DVFMEYNLIQ QCTAFLLDAL KNNRPSEGPL QTRLLEMNLM HAPQVADAIL 
       610        620        630        640        650
GNQMFTHYDR AHIAQLCEKA GLLQRALEHF TDLYDIKRAV VHTHLLNPEW 
       660        670        680        690        700
LVNYFGSLSV EDSLECLRAM LSANIRQNLQ IWVQVASKYH EQLSTQSLIE 
       710        720        730        740        750
LFESFKSFEG LFYFLGSIVN FSQDPDVHFK YIQAACKTGQ IKEVERICRE 
       760        770        780        790        800
SNCYDPERVK NFLKEAKLTD QLPLIIVCDR FDFVHDLVLY LYRNSLQKYI 
       810        820        830        840        850
EIYVQKVNPS RLPVVIGGLL DVDCSEDVIK NLILVVRGQF STDELVAEVE 
       860        870        880        890        900
KRNRLKLLLP WLEARIHEGC EEPATHNALA KIYIDSNNNP ERFLRENPYY 
       910        920        930        940        950
DSRVVGKYCE KRDPHLACVA YERGQCDLEL INVCNENSLF KSLSRYLVRR 
       960        970        980        990       1000
KDPELWGSVL LESNPYRRPL IDQVVQTALS ETQDPEEVSV TVKAFMTADL 
      1010       1020       1030       1040       1050
PNELIELLEK IVLDNSVFSE HRNLQNLLIL TAIKADRTRV MEYINRLDNY 
      1060       1070       1080       1090       1100
DAPDIANIAI SNELFEEAFA IFRKFDVNTS AVQVLIEHIG NLDRAYEFAE 
      1110       1120       1130       1140       1150
RCNEPAVWSQ LAKAQLQKGM VKEAIDSYIK ADDPSSYMEV VQAANTSGNW 
      1160       1170       1180       1190       1200
EELVKYLQMA RKKARESYVE TELIFALAKT NRLAELEEFI NGPNNAHIQQ 
      1210       1220       1230       1240       1250
VGDRCYDEKM YDAAKLLYNN VSNFGRLAST LVHLGEYQAA VDGARKANST 
      1260       1270       1280       1290       1300
RTWKEVCFAC VDGKEFRLAQ MCGLHIVVHA DELEELINYY QDRGYFEELI 
      1310       1320       1330       1340       1350
TMLEAALGLE RAHMGMFTEL AILYSKFKPQ KMREHLELFW SRVNIPKVLR 
      1360       1370       1380       1390       1400
AAEQAHLWAE LVFLYDKYEE YDNAIITMMN HPTDAWKEGQ FKDIITKVAN 
      1410       1420       1430       1440       1450
VELYYKAIQF YLEFKPLLLN DLLMVLSPRL AHTRAVNYFS KVKQLPLVKP 
      1460       1470       1480       1490       1500
YLRSVQNHNN KSVNESLNNL FITEEDYQAL RTSIDAYDNF DNISLAQRLE 
      1510       1520       1530       1540       1550
KHELIEFRRI AAYLFKGNNR WKQSVELCKK DSLYKDAMQY ASESKDTELA 
      1560       1570       1580       1590       1600
EELLQWFLQE EKRECFGACL FTCYDLLRPD VVLETAWRHN IMDFAMPYFI 
      1610       1620       1630       1640       1650
QVMKEYLTKV DKLDASESLR KEEEQATETQ PIVYGQPQLM LTAGPSVAVP 
      1660       1670 
PQAPFGYGYT APPYGQPQPG FGYSM
Length:1,675
Mass (Da):191,599
Last modified:January 23, 2007 - v3
Checksum:iC10F54C7ED8C5A61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03583 mRNA Translation: AAA40874.1
PIRiA39941 LRRTH
RefSeqiNP_062172.1, NM_019299.1
UniGeneiRn.3589

Genome annotation databases

GeneIDi54241
KEGGirno:54241

Similar proteinsi

Entry informationi

Entry nameiCLH1_RAT
AccessioniPrimary (citable) accession number: P11442
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 23, 2007
Last modified: July 18, 2018
This is version 160 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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