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Protein

Ubiquitin-like protein 4A

Gene

UBL4A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20676083, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20676083, PubMed:28104892, PubMed:25535373). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome (PubMed:28104892). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303).5 Publications

GO - Molecular functioni

  • chaperone binding Source: BHF-UCL
  • ubiquitin-like protein transferase activity Source: ProtInc

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-like protein 4ACurated
Alternative name(s):
Ubiquitin-like protein GDX
Gene namesi
Name:UBL4AImported
Synonyms:DXS254E, GDX, UBL4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000102178.12
HGNCiHGNC:12505 UBL4A
MIMi312070 gene
neXtProtiNX_P11441

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi43L → A: Reduces tail-anchored proteins delivery. 1 Publication1
Mutagenesisi48K → R: Loss of polyubiquitination by AMFR. 1 Publication1
Mutagenesisi102V → E or K: No effect on interaction with BAG6. 1 Publication1
Mutagenesisi105R → E: No effect on interaction with BAG6. 1 Publication1
Mutagenesisi106H → E: Strongly inhibits interaction with BAG6. 1 Publication1
Mutagenesisi107F → E or K: Strongly inhibits interaction with BAG6. 1 Publication1
Mutagenesisi123Y → E: No effect on interaction with BAG6. 1 Publication1
Mutagenesisi130L → E or K: No effect on interaction with BAG6. 1 Publication1

Organism-specific databases

DisGeNETi8266
OpenTargetsiENSG00000102178
PharmGKBiPA37152

Polymorphism and mutation databases

DMDMi136662

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001148641 – 157Ubiquitin-like protein 4AAdd BLAST157

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki48Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei90PhosphoserineCombined sources1

Post-translational modificationi

Polyubiquitinated. Ubiquitination by AMFR and deubiquitination by USP13 may regulate the interaction between the BAG6/BAT3 complex and SGTA and therefore may regulate client proteins fate.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP11441
MaxQBiP11441
PaxDbiP11441
PeptideAtlasiP11441
PRIDEiP11441
ProteomicsDBi52774

PTM databases

iPTMnetiP11441
PhosphoSitePlusiP11441

Expressioni

Gene expression databases

BgeeiENSG00000102178 Expressed in 213 organ(s), highest expression level in muscle of leg
CleanExiHS_UBL4A
ExpressionAtlasiP11441 baseline and differential
GenevisibleiP11441 HS

Organism-specific databases

HPAiHPA003617

Interactioni

Subunit structurei

Component of the BAG6/BAT3 complex, at least composed of BAG6, UBL4A and GET4/TRC35 (PubMed:20676083, PubMed:25535373). Interacts with BAG6; the interaction is direct and required for UBL4A protein stability (PubMed:25713138, PubMed:25535373). Interacts with USP13; may be indirect via BAG6 (PubMed:24424410).4 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi113885, 308 interactors
ComplexPortaliCPX-132 BAT3 complex
IntActiP11441, 51 interactors
MINTiP11441
STRINGi9606.ENSP00000358674

Structurei

Secondary structure

1157
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP11441
SMRiP11441
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP11441

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 76Ubiquitin-likePROSITE-ProRule annotationAdd BLAST76

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni96 – 138Required and sufficient for interaction with BAG62 PublicationsAdd BLAST43

Phylogenomic databases

eggNOGiKOG0001 Eukaryota
COG5272 LUCA
GeneTreeiENSGT00730000111022
HOGENOMiHOG000006827
HOVERGENiHBG072205
InParanoidiP11441
OMAiYPGIKDG
PhylomeDBiP11441
TreeFamiTF354228

Family and domain databases

InterProiView protein in InterPro
IPR019956 Ubiquitin
IPR029071 Ubiquitin-like_domsf
IPR019954 Ubiquitin_CS
IPR000626 Ubiquitin_dom
PfamiView protein in Pfam
PF00240 ubiquitin, 1 hit
PRINTSiPR00348 UBIQUITIN
SMARTiView protein in SMART
SM00213 UBQ, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS00299 UBIQUITIN_1, 1 hit
PS50053 UBIQUITIN_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P11441-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQLTVKALQG RECSLQVPED ELVSTLKQLV SEKLNVPVRQ QRLLFKGKAL
60 70 80 90 100
ADGKRLSDYS IGPNSKLNLV VKPLEKVLLE EGEAQRLADS PPPQVWQLIS
110 120 130 140 150
KVLARHFSAA DASRVLEQLQ RDYERSLSRL TLDDIERLAS RFLHPEVTET

MEKGFSK
Length:157
Mass (Da):17,777
Last modified:October 1, 1989 - v1
Checksum:i9D6EE2D20D2C4C60
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5HY81Q5HY81_HUMAN
Ubiquitin-like protein 4A
UBL4A
180Annotation score:
F8WB70F8WB70_HUMAN
Ubiquitin-like protein 4A
UBL4A
103Annotation score:
F8WCT8F8WCT8_HUMAN
Ubiquitin-like protein 4A
UBL4A
33Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03589 Genomic DNA Translation: AAA36790.1
L44140 Genomic DNA Translation: AAA92650.1
BX664739 Genomic DNA No translation available.
CH471172 Genomic DNA Translation: EAW72700.1
BC043346 mRNA Translation: AAH43346.1
BC053589 mRNA Translation: AAH53589.1
CCDSiCCDS14754.1
PIRiA31084
RefSeqiNP_055050.1, NM_014235.4
UniGeneiHs.76480

Genome annotation databases

EnsembliENST00000369660; ENSP00000358674; ENSG00000102178
GeneIDi8266
KEGGihsa:8266
UCSCiuc004flo.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03589 Genomic DNA Translation: AAA36790.1
L44140 Genomic DNA Translation: AAA92650.1
BX664739 Genomic DNA No translation available.
CH471172 Genomic DNA Translation: EAW72700.1
BC043346 mRNA Translation: AAH43346.1
BC053589 mRNA Translation: AAH53589.1
CCDSiCCDS14754.1
PIRiA31084
RefSeqiNP_055050.1, NM_014235.4
UniGeneiHs.76480

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DZINMR-A1-74[»]
4WWRX-ray2.00B/D/F/H93-139[»]
4X86X-ray1.85A95-147[»]
ProteinModelPortaliP11441
SMRiP11441
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113885, 308 interactors
ComplexPortaliCPX-132 BAT3 complex
IntActiP11441, 51 interactors
MINTiP11441
STRINGi9606.ENSP00000358674

PTM databases

iPTMnetiP11441
PhosphoSitePlusiP11441

Polymorphism and mutation databases

DMDMi136662

Proteomic databases

EPDiP11441
MaxQBiP11441
PaxDbiP11441
PeptideAtlasiP11441
PRIDEiP11441
ProteomicsDBi52774

Protocols and materials databases

DNASUi8266
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369660; ENSP00000358674; ENSG00000102178
GeneIDi8266
KEGGihsa:8266
UCSCiuc004flo.4 human

Organism-specific databases

CTDi8266
DisGeNETi8266
EuPathDBiHostDB:ENSG00000102178.12
GeneCardsiUBL4A
HGNCiHGNC:12505 UBL4A
HPAiHPA003617
MIMi312070 gene
neXtProtiNX_P11441
OpenTargetsiENSG00000102178
PharmGKBiPA37152
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0001 Eukaryota
COG5272 LUCA
GeneTreeiENSGT00730000111022
HOGENOMiHOG000006827
HOVERGENiHBG072205
InParanoidiP11441
OMAiYPGIKDG
PhylomeDBiP11441
TreeFamiTF354228

Miscellaneous databases

EvolutionaryTraceiP11441
GeneWikiiUBL4A
GenomeRNAii8266
PROiPR:P11441
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000102178 Expressed in 213 organ(s), highest expression level in muscle of leg
CleanExiHS_UBL4A
ExpressionAtlasiP11441 baseline and differential
GenevisibleiP11441 HS

Family and domain databases

InterProiView protein in InterPro
IPR019956 Ubiquitin
IPR029071 Ubiquitin-like_domsf
IPR019954 Ubiquitin_CS
IPR000626 Ubiquitin_dom
PfamiView protein in Pfam
PF00240 ubiquitin, 1 hit
PRINTSiPR00348 UBIQUITIN
SMARTiView protein in SMART
SM00213 UBQ, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS00299 UBIQUITIN_1, 1 hit
PS50053 UBIQUITIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUBL4A_HUMAN
AccessioniPrimary (citable) accession number: P11441
Secondary accession number(s): Q5HY80
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: September 12, 2018
This is version 172 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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