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Protein

Lysosome-associated membrane glycoprotein 1

Gene

Lamp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis.

GO - Molecular functioni

  • enzyme binding Source: MGI
  • protein domain specific binding Source: UniProtKB

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosome-associated membrane glycoprotein 1
Short name:
LAMP-1
Short name:
Lysosome-associated membrane protein 1
Alternative name(s):
120 kDa lysosomal membrane glycoprotein
CD107 antigen-like family member A
LGP-120
Lysosomal membrane glycoprotein A
Short name:
LGP-A
P2B
CD_antigen: CD107a
Gene namesi
Name:Lamp1
Synonyms:Lamp-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:96745 Lamp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 370LumenalSequence analysisAdd BLAST346
Transmembranei371 – 394HelicalPROSITE-ProRule annotationAdd BLAST24
Topological domaini395 – 406CytoplasmicPROSITE-ProRule annotationAdd BLAST12

Keywords - Cellular componenti

Cell membrane, Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 241 PublicationAdd BLAST24
ChainiPRO_000001710525 – 406Lysosome-associated membrane glycoprotein 1Add BLAST382

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi31N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi35 ↔ 74PROSITE-ProRule annotation1 Publication
Glycosylationi52N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi58N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi70N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi78N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi97N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi101N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi115N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi149 ↔ 185PROSITE-ProRule annotation1 Publication
Glycosylationi159N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi177N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi214N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi219N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi222 ↔ 259PROSITE-ProRule annotation1 Publication
Glycosylationi232N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi240N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi252N-linked (GlcNAc...) (high mannose) asparagine1 Publication1
Glycosylationi282N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi296N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi311N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi327 ↔ 364PROSITE-ProRule annotation1 Publication

Post-translational modificationi

O- and N-glycosylated; some of the N-glycans attached to LAMP-1 are polylactosaminoglycans.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP11438
PaxDbiP11438
PeptideAtlasiP11438
PRIDEiP11438

PTM databases

iPTMnetiP11438
PhosphoSitePlusiP11438
UniCarbKBiP11438

Expressioni

Gene expression databases

BgeeiENSMUSG00000031447 Expressed in 304 organ(s), highest expression level in stroma of bone marrow
CleanExiMM_LAMP1
ExpressionAtlasiP11438 baseline and differential
GenevisibleiP11438 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiP11438, 19 interactors
MINTiP11438
STRINGi10090.ENSMUSP00000033824

Structurei

Secondary structure

1406
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP11438
SMRiP11438
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 188First lumenal domainAdd BLAST164
Regioni189 – 218HingeAdd BLAST30
Regioni219 – 370Second lumenal domainAdd BLAST152

Sequence similaritiesi

Belongs to the LAMP family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4818 Eukaryota
ENOG410XQ96 LUCA
GeneTreeiENSGT00530000063068
HOGENOMiHOG000230942
HOVERGENiHBG052303
InParanoidiP11438
KOiK06528
OMAiSKEETRC
OrthoDBiEOG091G09EV
PhylomeDBiP11438
TreeFamiTF316339

Family and domain databases

InterProiView protein in InterPro
IPR018134 LAMP_CS
IPR002000 Lysosome-assoc_membr_glycop
PANTHERiPTHR11506 PTHR11506, 1 hit
PfamiView protein in Pfam
PF01299 Lamp, 1 hit
PRINTSiPR00336 LYSASSOCTDMP
PROSITEiView protein in PROSITE
PS00310 LAMP_1, 2 hits
PS00311 LAMP_2, 1 hit
PS51407 LAMP_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11438-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAPGARRPL LLLLLAGLAH GASALFEVKN NGTTCIMASF SASFLTTYET
60 70 80 90 100
ANGSQIVNIS LPASAEVLKN GSSCGKENVS DPSLTITFGR GYLLTLNFTK
110 120 130 140 150
NTTRYSVQHM YFTYNLSDTE HFPNAISKEI YTMDSTTDIK ADINKAYRCV
160 170 180 190 200
SDIRVYMKNV TVVLRDATIQ AYLSSGNFSK EETHCTQDGP SPTTGPPSPS
210 220 230 240 250
PPLVPTNPTV SKYNVTGNNG TCLLASMALQ LNITYLKKDN KTVTRAFNIS
260 270 280 290 300
PNDTSSGSCG INLVTLKVEN KNRALELQFG MNASSSLFFL QGVRLNMTLP
310 320 330 340 350
DALVPTFSIS NHSLKALQAT VGNSYKCNTE EHIFVSKMLS LNVFSVQVQA
360 370 380 390 400
FKVDSDRFGS VEECVQDGNN MLIPIAVGGA LAGLVLIVLI AYLIGRKRSH

AGYQTI
Length:406
Mass (Da):43,865
Last modified:August 1, 1990 - v2
Checksum:iC1BD373548BB9655
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1 – 10MAAPGARRPL → MRPPRAAAV (PubMed:2676155).Curated10
Sequence conflicti25 – 26LF → IP in AAA39411 (PubMed:3379044).Curated2
Sequence conflicti385V → I (PubMed:2676155).Curated1
Sequence conflicti385V → I (PubMed:3379044).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32015 mRNA Translation: AAA39428.1
M25244 mRNA Translation: AAA39869.1
BC049097 mRNA Translation: AAH49097.1
J03881 mRNA Translation: AAA39411.1
CCDSiCCDS22106.1
PIRiA28067
A60534
RefSeqiNP_001304282.1, NM_001317353.1
NP_034814.2, NM_010684.3
UniGeneiMm.16716

Genome annotation databases

EnsembliENSMUST00000033824; ENSMUSP00000033824; ENSMUSG00000031447
GeneIDi16783
KEGGimmu:16783
UCSCiuc009kxa.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32015 mRNA Translation: AAA39428.1
M25244 mRNA Translation: AAA39869.1
BC049097 mRNA Translation: AAH49097.1
J03881 mRNA Translation: AAA39411.1
CCDSiCCDS22106.1
PIRiA28067
A60534
RefSeqiNP_001304282.1, NM_001317353.1
NP_034814.2, NM_010684.3
UniGeneiMm.16716

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5GV0X-ray1.50A208-370[»]
ProteinModelPortaliP11438
SMRiP11438
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP11438, 19 interactors
MINTiP11438
STRINGi10090.ENSMUSP00000033824

PTM databases

iPTMnetiP11438
PhosphoSitePlusiP11438
UniCarbKBiP11438

Proteomic databases

EPDiP11438
PaxDbiP11438
PeptideAtlasiP11438
PRIDEiP11438

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033824; ENSMUSP00000033824; ENSMUSG00000031447
GeneIDi16783
KEGGimmu:16783
UCSCiuc009kxa.1 mouse

Organism-specific databases

CTDi3916
MGIiMGI:96745 Lamp1

Phylogenomic databases

eggNOGiKOG4818 Eukaryota
ENOG410XQ96 LUCA
GeneTreeiENSGT00530000063068
HOGENOMiHOG000230942
HOVERGENiHBG052303
InParanoidiP11438
KOiK06528
OMAiSKEETRC
OrthoDBiEOG091G09EV
PhylomeDBiP11438
TreeFamiTF316339

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSiLamp1 mouse
PROiPR:P11438
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031447 Expressed in 304 organ(s), highest expression level in stroma of bone marrow
CleanExiMM_LAMP1
ExpressionAtlasiP11438 baseline and differential
GenevisibleiP11438 MM

Family and domain databases

InterProiView protein in InterPro
IPR018134 LAMP_CS
IPR002000 Lysosome-assoc_membr_glycop
PANTHERiPTHR11506 PTHR11506, 1 hit
PfamiView protein in Pfam
PF01299 Lamp, 1 hit
PRINTSiPR00336 LYSASSOCTDMP
PROSITEiView protein in PROSITE
PS00310 LAMP_1, 2 hits
PS00311 LAMP_2, 1 hit
PS51407 LAMP_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLAMP1_MOUSE
AccessioniPrimary (citable) accession number: P11438
Secondary accession number(s): Q62020
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: August 1, 1990
Last modified: November 7, 2018
This is version 158 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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