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Entry version 200 (12 Aug 2020)
Sequence version 2 (01 Feb 1996)
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Protein

Cell division control protein 24

Gene

CDC24

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Promotes the exchange of CDC42-bound GDP by GTP. Controls the polarity of calmodulin, and the calcium regulatory process of bud emergence. CDC24 may be involved in the initial selection and organization of the budding site.1 Publication

Miscellaneous

Present with 1010 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • Rho guanyl-nucleotide exchange factor activity Source: SGD

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-28849-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cell division control protein 24
Alternative name(s):
Calcium regulatory protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CDC24
Synonyms:CLS4
Ordered Locus Names:YAL041W
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:YAL041W

Saccharomyces Genome Database

More...
SGDi
S000000039, CDC24

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000809341 – 854Cell division control protein 24Add BLAST854

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P11433

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P11433

PRoteomics IDEntifications database

More...
PRIDEi
P11433

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P11433

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with AXL2.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
31724, 697 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-3462, CLA4-BEM1-CDC24 polarity complex
CPX-977, CDC24-FAR1-Gbetagamma complex

Database of interacting proteins

More...
DIPi
DIP-2228N

Protein interaction database and analysis system

More...
IntActi
P11433, 41 interactors

Molecular INTeraction database

More...
MINTi
P11433

STRING: functional protein association networks

More...
STRINGi
4932.YAL041W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P11433, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1854
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P11433

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P11433

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini135 – 246Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST112
Domaini278 – 454DHPROSITE-ProRule annotationAdd BLAST177
Domaini478 – 668PHPROSITE-ProRule annotationAdd BLAST191
Domaini761 – 854PB1PROSITE-ProRule annotationAdd BLAST94

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi494 – 600Ser/Thr-richAdd BLAST107
Compositional biasi681 – 778Ser/Thr-richAdd BLAST98

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3519, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000174094

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007879_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P11433

KEGG Orthology (KO)

More...
KOi
K11236

Identification of Orthologs from Complete Genome Data

More...
OMAi
GYRIAKF

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13246, PH_Scd1, 1 hit
cd00160, RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 1 hit
1.20.900.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010481, Cdc24/Scd1_N
IPR033511, Cdc24/Scd1_PH_dom
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR001331, GDS_CDC24_CS
IPR000270, PB1_dom
IPR001849, PH_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06395, CDC24, 1 hit
PF00621, RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033, CH, 1 hit
SM00666, PB1, 1 hit
SM00233, PH, 1 hit
SM00325, RhoGEF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48065, SSF48065, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50021, CH, 1 hit
PS00741, DH_1, 1 hit
PS50010, DH_2, 1 hit
PS51745, PB1, 1 hit
PS50003, PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P11433-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAIQTRFASG TSLSDLKPKP SATSISIPMQ NVMNKPVTEQ DSLFHICANI
60 70 80 90 100
RKRLEVLPQL KPFLQLAYQS SEVLSERQSL LLSQKQHQEL LKSNGANRDS
110 120 130 140 150
SDLAPTLRSS SISTATSLMS MEGISYTNSN PSATPNMEDT LLTFSMGILP
160 170 180 190 200
ITMDCDPVTQ LSQLFQQGAP LCILFNSVKP QFKLPVIASD DLKVCKKSIY
210 220 230 240 250
DFILGCKKHF AFNDEELFTI SDVFANSTSQ LVKVLEVVET LMNSSPTIFP
260 270 280 290 300
SKSKTQQIMN AENQHRHQPQ QSSKKHNEYV KIIKEFVATE RKYVHDLEIL
310 320 330 340 350
DKYRQQLLDS NLITSEELYM LFPNLGDAID FQRRFLISLE INALVEPSKQ
360 370 380 390 400
RIGALFMHSK HFFKLYEPWS IGQNAAIEFL SSTLHKMRVD ESQRFIINNK
410 420 430 440 450
LELQSFLYKP VQRLCRYPLL VKELLAESSD DNNTKELEAA LDISKNIARS
460 470 480 490 500
INENQRRTEN HQVVKKLYGR VVNWKGYRIS KFGELLYFDK VFISTTNSSS
510 520 530 540 550
EPEREFEVYL FEKIIILFSE VVTKKSASSL ILKKKSSTSA SISASNITDN
560 570 580 590 600
NGSPHHSYHK RHSNSSSSNN IHLSSSSAAA IIHSSTNSSD NNSNNSSSSS
610 620 630 640 650
LFKLSANEPK LDLRGRIMIM NLNQIIPQNN RSLNITWESI KEQGNFLLKF
660 670 680 690 700
KNEETRDNWS SCLQQLIHDL KNEQFKARHH SSTSTTSSTA KSSSMMSPTT
710 720 730 740 750
TMNTPNHHNS RQTHDSMASF SSSHMKRVSD VLPKRRTTSS SFESEIKSIS
760 770 780 790 800
ENFKNSIPES SILFRISYNN NSNNTSSSEI FTLLVEKVWN FDDLIMAINS
810 820 830 840 850
KISNTHNNNI SPITKIKYQD EDGDFVVLGS DEDWNVAKEM LAENNEKFLN

IRLY
Length:854
Mass (Da):96,940
Last modified:February 1, 1996 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i856BCAF4EB0A67D1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M16809 Genomic DNA Translation: AAA82871.1
U12980 Genomic DNA Translation: AAC04990.1
BK006935 Genomic DNA Translation: DAA06945.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A27477

NCBI Reference Sequences

More...
RefSeqi
NP_009359.1, NM_001178186.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YAL041W_mRNA; YAL041W; YAL041W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
851190

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YAL041W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16809 Genomic DNA Translation: AAA82871.1
U12980 Genomic DNA Translation: AAC04990.1
BK006935 Genomic DNA Translation: DAA06945.1
PIRiA27477
RefSeqiNP_009359.1, NM_001178186.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PQSNMR-A778-854[»]
1Q1ONMR-A761-854[»]
1TZ1NMR-A780-854[»]
2KFJNMR-A761-854[»]
2KFKNMR-B761-854[»]
SMRiP11433
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi31724, 697 interactors
ComplexPortaliCPX-3462, CLA4-BEM1-CDC24 polarity complex
CPX-977, CDC24-FAR1-Gbetagamma complex
DIPiDIP-2228N
IntActiP11433, 41 interactors
MINTiP11433
STRINGi4932.YAL041W

PTM databases

iPTMnetiP11433

Proteomic databases

MaxQBiP11433
PaxDbiP11433
PRIDEiP11433

Genome annotation databases

EnsemblFungiiYAL041W_mRNA; YAL041W; YAL041W
GeneIDi851190
KEGGisce:YAL041W

Organism-specific databases

EuPathDBiFungiDB:YAL041W
SGDiS000000039, CDC24

Phylogenomic databases

eggNOGiKOG3519, Eukaryota
GeneTreeiENSGT00940000174094
HOGENOMiCLU_007879_0_0_1
InParanoidiP11433
KOiK11236
OMAiGYRIAKF

Enzyme and pathway databases

BioCyciYEAST:G3O-28849-MONOMER

Miscellaneous databases

EvolutionaryTraceiP11433

Protein Ontology

More...
PROi
PR:P11433
RNActiP11433, protein

Family and domain databases

CDDicd13246, PH_Scd1, 1 hit
cd00160, RhoGEF, 1 hit
Gene3Di1.10.418.10, 1 hit
1.20.900.10, 1 hit
InterProiView protein in InterPro
IPR010481, Cdc24/Scd1_N
IPR033511, Cdc24/Scd1_PH_dom
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR001331, GDS_CDC24_CS
IPR000270, PB1_dom
IPR001849, PH_domain
PfamiView protein in Pfam
PF06395, CDC24, 1 hit
PF00621, RhoGEF, 1 hit
SMARTiView protein in SMART
SM00033, CH, 1 hit
SM00666, PB1, 1 hit
SM00233, PH, 1 hit
SM00325, RhoGEF, 1 hit
SUPFAMiSSF48065, SSF48065, 1 hit
PROSITEiView protein in PROSITE
PS50021, CH, 1 hit
PS00741, DH_1, 1 hit
PS50010, DH_2, 1 hit
PS51745, PB1, 1 hit
PS50003, PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCDC24_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P11433
Secondary accession number(s): D6VPH5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: February 1, 1996
Last modified: August 12, 2020
This is version 200 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names
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