UniProtKB - P11420 (DA_DROME)
Protein
Protein daughterless
Gene
da
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Daughterless/Achaete-scute complex heterodimers act as transcriptional activators of neural cell fates and are involved in sex determination.
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: FlyBase
- DNA-binding transcription factor activity Source: FlyBase
- protein heterodimerization activity Source: UniProtKB
- protein homodimerization activity Source: FlyBase
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific DNA binding Source: FlyBase
- transcription factor binding Source: FlyBase
GO - Biological processi
- chaeta morphogenesis Source: FlyBase
- female sex determination Source: FlyBase
- hindgut development Source: FlyBase
- Malpighian tubule tip cell differentiation Source: FlyBase
- neuroblast fate determination Source: FlyBase
- neuroendocrine cell differentiation Source: FlyBase
- neuron fate commitment Source: FlyBase
- oogenesis Source: FlyBase
- ovarian follicle cell development Source: FlyBase
- positive regulation of transcription, DNA-templated Source: FlyBase
- positive regulation of transcription by RNA polymerase II Source: FlyBase
- protein stabilization Source: FlyBase
- regulation of transcription by RNA polymerase II Source: GO_Central
- sensory organ development Source: FlyBase
- somatic stem cell population maintenance Source: FlyBase
Keywordsi
Molecular function | Activator, Developmental protein, DNA-binding |
Biological process | Differentiation, Neurogenesis, Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-DME-525793, Myogenesis R-DME-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs |
SignaLinki | P11420 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein daughterless |
Gene namesi | Name:da ORF Names:CG5102 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0267821, da |
Subcellular locationi
Nucleus
Nucleus
- nucleus Source: FlyBase
Other locations
- transcription regulator complex Source: FlyBase
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000127166 | 1 – 710 | Protein daughterlessAdd BLAST | 710 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 43 | Phosphoserine1 Publication | 1 | |
Modified residuei | 535 | Phosphoserine1 Publication | 1 | |
Modified residuei | 536 | Phosphoserine1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | P11420 |
PTM databases
iPTMneti | P11420 |
Expressioni
Tissue specificityi
Ubiquitous.
Gene expression databases
Bgeei | FBgn0000413, Expressed in cleaving embryo and 37 other tissues |
ExpressionAtlasi | P11420, baseline and differential |
Genevisiblei | P11420, DM |
Interactioni
Subunit structurei
Homodimer. Efficient DNA binding requires dimerization with another bHLH protein.
Interacts with Amos.
Interacts (via bHLH motif) with sisA and sc.
Interacts with dpn (via bHLH motif).
1 PublicationGO - Molecular functioni
- protein heterodimerization activity Source: UniProtKB
- protein homodimerization activity Source: FlyBase
- transcription factor binding Source: FlyBase
Protein-protein interaction databases
BioGRIDi | 60497, 56 interactors |
DIPi | DIP-50N |
IntActi | P11420, 25 interactors |
STRINGi | 7227.FBpp0304504 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 198 – 226 | His-richAdd BLAST | 29 | |
Repeati | 227 – 256 | His-richAdd BLAST | 30 | |
Domaini | 554 – 607 | bHLHPROSITE-ProRule annotationAdd BLAST | 54 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 609 – 632 | Class A specific domainAdd BLAST | 24 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG3910, Eukaryota |
GeneTreei | ENSGT00940000168822 |
HOGENOMi | CLU_387465_0_0_1 |
InParanoidi | P11420 |
OMAi | HTMASVF |
OrthoDBi | 571132at2759 |
PhylomeDBi | P11420 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
P11420-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATSDDEPMH LYEVFQNCFN KIANKQPTGT VGADRGGGGG YHSPYGSLGV
60 70 80 90 100
ENGMYPSDFN SMHDTVNGGN NRYANASTVD QYFDSAAAGS GGAWCQPQMS
110 120 130 140 150
SANSYMGQSA YQNSGPLSGH SIDQQQQQVH QADGLGMGGG GGGGVGADGM
160 170 180 190 200
HCPVTTGLPP ISSFRPTSGG IGGPGAGQQA PVNVNVNPPA VFNSPQAHNH
210 220 230 240 250
NHTVQAQHSA LSTAGPLGHH SLNHTPHAHS HTLPLPHALP HGHTLPHPHH
260 270 280 290 300
SQQNSPAVQS SDAFSGAGAS VKVAGAGNSS AAALRQQMYM PADQSISSFG
310 320 330 340 350
SNPSTPVNSP PPLTQSVVGG GGEPSVSGGS GWGHSVLNGG PSSSYASEMV
360 370 380 390 400
PVSSLHTMAS VFQGVRMEER LDDALNVLRN HCEPEMLAGV NQSLASIDNI
410 420 430 440 450
DALTSFVPNS PSHLGSGGNS GSVSNTSNAA LVHEVLALGA AAAAGTSGQS
460 470 480 490 500
VGGAGSLASL KLDRSASTSL PKQTKKRKEH TAISNSVPAG VSTTSSLTSL
510 520 530 540 550
DISDTKPTSS IESSNSGLQQ HSQGKGTKRP RRYCSSADED DDAEPAVKAI
560 570 580 590 600
REKERRQANN ARERIRIRDI NEALKELGRM CMTHLKSDKP QTKLGILNMA
610 620 630 640 650
VEVIMTLEQQ VRERNLNPKA ACLKRREEEK AEDGPKLSAQ HHMIPQPQQV
660 670 680 690 700
GGTPGSSYHS QPAQLVPPSS QTISTMTISL PVNQANNGLP PHLQQQQQQQ
710
SQLGHAQLPQ
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC8VV95 | C8VV95_DROME | Daughterless, isoform B | da 5102, bHLHb22, DA, Da, da-RA | 710 | Annotation score: | ||
A0A4D6K5Q8 | A0A4D6K5Q8_DROME | Daughterless, isoform D | da 5102, bHLHb22, DA, Da, Dmel\CG5102 | 775 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03148 mRNA Translation: AAA28442.1 Y00221 mRNA Translation: CAA68368.1 AE014134 Genomic DNA Translation: AAF52934.2 |
PIRi | S06891, A31641 |
RefSeqi | NP_001260340.1, NM_001273411.1 NP_001260341.1, NM_001273412.1 NP_477189.1, NM_057841.4 |
Genome annotation databases
EnsemblMetazoai | FBtr0080008; FBpp0079598; FBgn0267821 FBtr0332195; FBpp0304504; FBgn0267821 FBtr0332196; FBpp0304505; FBgn0267821 |
GeneIDi | 34413 |
KEGGi | dme:Dmel_CG5102 |
UCSCi | CG5102-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03148 mRNA Translation: AAA28442.1 Y00221 mRNA Translation: CAA68368.1 AE014134 Genomic DNA Translation: AAF52934.2 |
PIRi | S06891, A31641 |
RefSeqi | NP_001260340.1, NM_001273411.1 NP_001260341.1, NM_001273412.1 NP_477189.1, NM_057841.4 |
3D structure databases
SMRi | P11420 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 60497, 56 interactors |
DIPi | DIP-50N |
IntActi | P11420, 25 interactors |
STRINGi | 7227.FBpp0304504 |
PTM databases
iPTMneti | P11420 |
Proteomic databases
PaxDbi | P11420 |
Genome annotation databases
EnsemblMetazoai | FBtr0080008; FBpp0079598; FBgn0267821 FBtr0332195; FBpp0304504; FBgn0267821 FBtr0332196; FBpp0304505; FBgn0267821 |
GeneIDi | 34413 |
KEGGi | dme:Dmel_CG5102 |
UCSCi | CG5102-RA, d. melanogaster |
Organism-specific databases
CTDi | 13130 |
FlyBasei | FBgn0267821, da |
Phylogenomic databases
eggNOGi | KOG3910, Eukaryota |
GeneTreei | ENSGT00940000168822 |
HOGENOMi | CLU_387465_0_0_1 |
InParanoidi | P11420 |
OMAi | HTMASVF |
OrthoDBi | 571132at2759 |
PhylomeDBi | P11420 |
Enzyme and pathway databases
Reactomei | R-DME-525793, Myogenesis R-DME-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs |
SignaLinki | P11420 |
Miscellaneous databases
BioGRID-ORCSi | 34413, 0 hits in 3 CRISPR screens |
GenomeRNAii | 34413 |
PROi | PR:P11420 |
Gene expression databases
Bgeei | FBgn0000413, Expressed in cleaving embryo and 37 other tissues |
ExpressionAtlasi | P11420, baseline and differential |
Genevisiblei | P11420, DM |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DA_DROME | |
Accessioni | P11420Primary (citable) accession number: P11420 Secondary accession number(s): Q9VKX3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1989 |
Last sequence update: | October 1, 1989 | |
Last modified: | April 7, 2021 | |
This is version 201 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase