Protein daughterless

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• bHLH transcription factor binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: FlyBase <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "bHLH proteins encoded by the Enhancer of split complex of Drosophila negatively interfere with transcriptional activation mediated by proneural genes."
    Oellers N., Dehio M., Knust E.
    Mol Gen Genet 244:465-473(1994) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity Source: FlyBaseInferred from direct assayⁱ
  • "Transcriptional activation by heterodimers of the achaete-scute and daughterless gene products of Drosophila."
    Cabrera C.V., Alonso M.C.
    EMBO J 10:2965-2973(1991) [PubMed] [Europe PMC] [Abstract]
• protein heterodimerization activity Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Dimerization partners determine the activity of the Twist bHLH protein during Drosophila mesoderm development."
    Castanon I., Von Stetina S., Kass J., Baylies M.K.
    Development 128:3145-3159(2001) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: FlyBaseInferred from physical interactionⁱ
  • "The Drosophila extramacrochaetae protein antagonizes sequence-specific DNA binding by daughterless/achaete-scute protein complexes."
    Van Doren M., Ellis H.M., Posakony J.W.
    Development 113:245-255(1991) [PubMed] [Europe PMC] [Abstract]
  • "Regulation of scute function by extramacrochaete in vitro and in vivo."
    Cabrera C.V., Alonso M.C., Huikeshoven H.
    Development 120:3595-3603(1994) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• sequence-specific DNA binding Source: FlyBaseInferred from direct assayⁱ
  • "Target specificities of Drosophila enhancer of split basic helix-loop-helix proteins."
    Jennings B.H., Tyler D.M., Bray S.J.
    Mol Cell Biol 19:4600-4610(1999) [PubMed] [Europe PMC] [Abstract]
  • "The Drosophila extramacrochaetae protein antagonizes sequence-specific DNA binding by daughterless/achaete-scute protein complexes."
    Van Doren M., Ellis H.M., Posakony J.W.
    Development 113:245-255(1991) [PubMed] [Europe PMC] [Abstract]
  • "Regulation of scute function by extramacrochaete in vitro and in vivo."
    Cabrera C.V., Alonso M.C., Huikeshoven H.
    Development 120:3595-3603(1994) [PubMed] [Europe PMC] [Abstract]
• transcription factor binding Source: FlyBase <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Two modes of recruitment of E(spl) repressors onto target genes."
    Giagtzoglou N., Alifragis P., Koumbanakis K.A., Delidakis C.
    Development 130:259-270(2003) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• chaeta morphogenesis Source: FlyBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Evidence that nervy, the Drosophila homolog of ETO/MTG8, promotes mechanosensory organ development by enhancing Notch signaling."
    Wildonger J., Mann R.S.
    Dev Biol 286:507-520(2005) [PubMed] [Europe PMC] [Abstract]
• female sex determination Source: FlyBaseInferred from mutant phenotypeⁱ
  • "The m6A pathway facilitates sex determination in Drosophila."
    Kan L., Grozhik A.V., Vedanayagam J., Patil D.P., Pang N., Lim K.S., Huang Y.C., Joseph B., Lin C.J., Despic V., Guo J., Yan D., Kondo S., Deng W.M., Dedon P.C., Jaffrey S.R., Lai E.C.
    Nat. Commun. 8:15737-15737(2017) [PubMed] [Europe PMC] [Abstract]
• hindgut development Source: FlyBaseInferred from mutant phenotypeⁱ
  • "E and ID proteins regulate cell chirality and left-right asymmetric development in Drosophila."
    Ishibashi T., Hatori R., Maeda R., Nakamura M., Taguchi T., Matsuyama Y., Matsuno K.
    Genes Cells 24:214-230(2019) [PubMed] [Europe PMC] [Abstract]
• Malpighian tubule tip cell differentiation Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Sequential fates in a single cell are established by the neurogenic cascade in the Malpighian tubules of Drosophila."
    Hoch M., Broadie K., Jackle H., Skaer H.
    Development 120:3439-3450(1994) [PubMed] [Europe PMC] [Abstract]
• neuroblast fate determination Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Drosophila optic lobe neuroblasts triggered by a wave of proneural gene expression that is negatively regulated by JAK/STAT."
    Yasugi T., Umetsu D., Murakami S., Sato M., Tabata T.
    Development 135:1471-1480(2008) [PubMed] [Europe PMC] [Abstract]
• neuroendocrine cell differentiation Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Specification of Drosophila corpora cardiaca neuroendocrine cells from mesoderm is regulated by Notch signaling."
    Park S., Bustamante E.L., Antonova J., McLean G.W., Kim S.K.
    PLoS Genet 7:e1002241-e1002241(2011) [PubMed] [Europe PMC] [Abstract]
• neuron fate commitment Source: FlyBaseInferred from mutant phenotypeⁱ
  • "A network of broadly expressed HLH genes regulates tissue-specific cell fates."
    Bhattacharya A., Baker N.E.
    Cell 147:881-892(2011) [PubMed] [Europe PMC] [Abstract]
• oogenesis Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Daughterless coordinates somatic cell proliferation, differentiation and germline cyst survival during follicle formation in Drosophila."
    Smith J.E., Cummings C.A., Cronmiller C.
    Development 129:3255-3267(2002) [PubMed] [Europe PMC] [Abstract]
• ovarian follicle cell development Source: FlyBaseInferred from mutant phenotypeⁱ
  • "The daughterless gene functions together with Notch and Delta in the control of ovarian follicle development in Drosophila."
    Cummings C.A., Cronmiller C.
    Development 120:381-394(1994) [PubMed] [Europe PMC] [Abstract]
• positive regulation of neuron differentiation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription, DNA-templated Source: FlyBaseInferred from direct assayⁱ
  • "Transcriptional activation by heterodimers of the achaete-scute and daughterless gene products of Drosophila."
    Cabrera C.V., Alonso M.C.
    EMBO J 10:2965-2973(1991) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Groucho restricts rhomboid expression and couples EGFR activation with R8 selection during Drosophila photoreceptor differentiation."
    Zhang T., Du W.
    Dev Biol 407:246-255(2015) [PubMed] [Europe PMC] [Abstract]
  • "The regulation and function of the helix-loop-helix gene, asense, in Drosophila neural precursors."
    Jarman A.P., Brand M., Jan L.Y., Jan Y.N.
    Development 119:19-29(1993) [PubMed] [Europe PMC] [Abstract]
• protein stabilization Source: FlyBaseInferred from direct assayⁱ
  • "Regulation of the Drosophila ID protein Extra macrochaetae by proneural dimerization partners."
    Li K., Baker N.E.
    Elife 7:0-0(2018) [PubMed] [Europe PMC] [Abstract]
• sensory organ development Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Senseless and Daughterless confer neuronal identity to epithelial cells in the Drosophila wing margin."
    Jafar-Nejad H., Tien A.C., Acar M., Bellen H.J.
    Development 133:1683-1692(2006) [PubMed] [Europe PMC] [Abstract]
• somatic stem cell population maintenance Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Transcriptional control of stem cell maintenance in the Drosophila intestine."
    Bardin A.J., Perdigoto C.N., Southall T.D., Brand A.H., Schweisguth F.
    Development 137:705-714(2010) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• bHLH transcription factor binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• protein heterodimerization activity Source: UniProtKBInferred from physical interactionⁱ
  • "Dimerization partners determine the activity of the Twist bHLH protein during Drosophila mesoderm development."
    Castanon I., Von Stetina S., Kass J., Baylies M.K.
    Development 128:3145-3159(2001) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: FlyBaseInferred from physical interactionⁱ
  • "The Drosophila extramacrochaetae protein antagonizes sequence-specific DNA binding by daughterless/achaete-scute protein complexes."
    Van Doren M., Ellis H.M., Posakony J.W.
    Development 113:245-255(1991) [PubMed] [Europe PMC] [Abstract]
  • "Regulation of scute function by extramacrochaete in vitro and in vivo."
    Cabrera C.V., Alonso M.C., Huikeshoven H.
    Development 120:3595-3603(1994) [PubMed] [Europe PMC] [Abstract]
• transcription factor binding Source: FlyBaseInferred from genetic interactionⁱ
  • "Two modes of recruitment of E(spl) repressors onto target genes."
    Giagtzoglou N., Alifragis P., Koumbanakis K.A., Delidakis C.
    Development 130:259-270(2003) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MATSDDEPMH LYEVFQNCFN KIANKQPTGT VGADRGGGGG YHSPYGSLGV 
        60         70         80         90        100
ENGMYPSDFN SMHDTVNGGN NRYANASTVD QYFDSAAAGS GGAWCQPQMS 
       110        120        130        140        150
SANSYMGQSA YQNSGPLSGH SIDQQQQQVH QADGLGMGGG GGGGVGADGM 
       160        170        180        190        200
HCPVTTGLPP ISSFRPTSGG IGGPGAGQQA PVNVNVNPPA VFNSPQAHNH 
       210        220        230        240        250
NHTVQAQHSA LSTAGPLGHH SLNHTPHAHS HTLPLPHALP HGHTLPHPHH 
       260        270        280        290        300
SQQNSPAVQS SDAFSGAGAS VKVAGAGNSS AAALRQQMYM PADQSISSFG 
       310        320        330        340        350
SNPSTPVNSP PPLTQSVVGG GGEPSVSGGS GWGHSVLNGG PSSSYASEMV 
       360        370        380        390        400
PVSSLHTMAS VFQGVRMEER LDDALNVLRN HCEPEMLAGV NQSLASIDNI 
       410        420        430        440        450
DALTSFVPNS PSHLGSGGNS GSVSNTSNAA LVHEVLALGA AAAAGTSGQS 
       460        470        480        490        500
VGGAGSLASL KLDRSASTSL PKQTKKRKEH TAISNSVPAG VSTTSSLTSL 
       510        520        530        540        550
DISDTKPTSS IESSNSGLQQ HSQGKGTKRP RRYCSSADED DDAEPAVKAI 
       560        570        580        590        600
REKERRQANN ARERIRIRDI NEALKELGRM CMTHLKSDKP QTKLGILNMA 
       610        620        630        640        650
VEVIMTLEQQ VRERNLNPKA ACLKRREEEK AEDGPKLSAQ HHMIPQPQQV 
       660        670        680        690        700
GGTPGSSYHS QPAQLVPPSS QTISTMTISL PVNQANNGLP PHLQQQQQQQ 
       710
SQLGHAQLPQ                                             

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Drosophila
   Drosophila: entries, gene names and cross-references to FlyBase