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UniProtKB - P11413 (G6PD_HUMAN)

Entry version 258 (29 Sep 2021)
Sequence version 4 (23 Jan 2007)
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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

G6PD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis.

4 Publications

Miscellaneous

Binds two molecules of NADP. The first one is a cosubstrate (bound to the N-terminal domain), the second is bound to the C-terminal domain and functions as a structural element.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=7.07 µM for NADP1 Publication
  2. KM=52 µM for glucose 6-phosphate1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).4 Publications This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei72NADP 1Combined sources2 Publications1
Binding sitei147NADP 1Combined sources2 Publications1
Binding sitei171NADP 1; via carbonyl oxygenCombined sources2 Publications1
Binding sitei171SubstrateCombined sources1 Publication1
Binding sitei239SubstrateCombined sources1 Publication1
Binding sitei258SubstrateCombined sources1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei263Proton acceptorBy similarity1
Binding sitei357NADP 2Combined sources2 Publications1
Binding sitei360SubstrateCombined sources1 Publication1
Binding sitei365SubstrateCombined sources1 Publication1
Binding sitei366NADP 2Combined sources2 Publications1
Binding sitei370NADP 2Combined sources2 Publications1
Binding sitei393NADP 2Combined sources2 Publications1
Binding sitei395SubstrateCombined sources1 Publication1
Binding sitei487NADP 2Combined sources2 Publications1
Binding sitei503NADP 2Combined sources2 Publications1
Binding sitei509NADP 2Combined sources2 Publications1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi38 – 45NADP 1Combined sources2 Publications8
Nucleotide bindingi401 – 403NADP 2Combined sources2 Publications3
Nucleotide bindingi421 – 423NADP 2Combined sources2 Publications3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processCarbohydrate metabolism, Glucose metabolism
LigandNADP

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS08467-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		1.1.1.49, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P11413

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-5628897, TP53 Regulates Metabolic Genes
R-HSA-71336, Pentose phosphate pathway

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		P11413

SIGNOR Signaling Network Open Resource

More...SIGNORi		P11413

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00115;UER00408

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.493 Publications)
Short name:
G6PD
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:G6PD
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:4057, G6PD

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		305900, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P11413

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000160211

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Anemia, non-spherocytic hemolytic, due to G6PD deficiency (NSHA)19 Publications
The disease is caused by variants affecting the gene represented in this entry. Deficiency of G6PD is associated with hemolytic anemia in two different situations. First, in areas in which malaria has been endemic, G6PD-deficiency alleles have reached high frequencies (1% to 50%) and deficient individuals, though essentially asymptomatic in the steady state, have a high risk of acute hemolytic attacks. Secondly, sporadic cases of G6PD deficiency occur at a very low frequencies, and they usually present a more severe phenotype. Several types of NSHA are recognized. Class-I variants are associated with severe NSHA; class-II have an activity <10% of normal; class-III have an activity of 10% to 60% of normal; class-IV have near normal activity.
Disease descriptionA disease characterized by G6PD deficiency, acute hemolytic anemia, fatigue, back pain, and jaundice. In most patients, the disease is triggered by an exogenous agent, such as some drugs, food, or infection. Increased unconjugated bilirubin, lactate dehydrogenase, and reticulocytosis are markers of the disorder. Although G6PD deficiency can be life-threatening, most patients are asymptomatic throughout their life.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00245132H → R in NSHA; Gahoe; class III; frequent in Chinese. 1 PublicationCorresponds to variant dbSNP:rs137852340Ensembl.1
Natural variantiVAR_00245235Missing in NSHA; Sunderland; class I. 1
Natural variantiVAR_00245344A → G in NSHA; Orissa; class III; frequent in Indian tribal populations. 1 PublicationCorresponds to variant dbSNP:rs78478128Ensembl.1
Natural variantiVAR_00245448I → T in NSHA; Aures; class II. 1 PublicationCorresponds to variant dbSNP:rs76645461Ensembl.1
Natural variantiVAR_00245558D → N in NSHA; Metaponto; class III. Corresponds to variant dbSNP:rs137852315Ensembl.1
Natural variantiVAR_00245668V → M in NSHA; A(-) type I; class III; frequent in African population. 4 PublicationsCorresponds to variant dbSNP:rs1050828Ensembl.1
Natural variantiVAR_00245770Y → H in NSHA; Namoru; 4% activity. Corresponds to variant dbSNP:rs137852349Ensembl.1
Natural variantiVAR_00245875L → P in NSHA; Swansea; class I. 1 Publication1
Natural variantiVAR_00246081R → C in NSHA; Konan/Ube; class III. Corresponds to variant dbSNP:rs138687036Ensembl.1
Natural variantiVAR_00245981R → H in NSHA; Lagosanto; class III. Corresponds to variant dbSNP:rs782308266Ensembl.1
Natural variantiVAR_002461106S → C in NSHA; Vancouver; class I. Corresponds to variant dbSNP:rs267606835EnsemblClinVar.1
Natural variantiVAR_002463128L → P in NSHA; Vanua Lava; 4% activity. Corresponds to variant dbSNP:rs78365220EnsemblClinVar.1
Natural variantiVAR_002465156E → K in NSHA; Ilesha; class III. Corresponds to variant dbSNP:rs137852313Ensembl.1
Natural variantiVAR_002467163G → D in NSHA; Plymouth; class I. 1 Publication1
Natural variantiVAR_002466163G → S in NSHA; Mahidol; class III; associated with reduced density of Plasmodium vivax but not Plasmodium falciparum in Southeast Asians; reduced activity. Corresponds to variant dbSNP:rs137852314Ensembl.1
Natural variantiVAR_002468165N → D in NSHA; Chinese-3; class II. Corresponds to variant dbSNP:rs137852331Ensembl.1
Natural variantiVAR_002469166R → H in NSHA; Naone; 1% activity. 1
Natural variantiVAR_002470176D → G in NSHA; Shinshu; class I. 1 Publication1
Natural variantiVAR_002471181D → V in NSHA; Santa Maria; class I. Corresponds to variant dbSNP:rs5030872Ensembl.1
Natural variantiVAR_002472182R → W in NSHA; Vancouver; class I. Corresponds to variant dbSNP:rs267606836EnsemblClinVar.1
Natural variantiVAR_002473188S → F in NSHA; Sassari/Cagliari; class II; frequent in the Mediterranean. 1 PublicationCorresponds to variant dbSNP:rs5030868Ensembl.1
Natural variantiVAR_002475198R → P in NSHA; Santiago; class I. 1 PublicationCorresponds to variant dbSNP:rs137852332Ensembl.1
Natural variantiVAR_075555198R → S in NSHA; Herlev; loss of glucose-6-phosphate dehydrogenase activity. 1 Publication1
Natural variantiVAR_002476212M → V in NSHA; Sibari; class III. Corresponds to variant dbSNP:rs782754619Ensembl.1
Natural variantiVAR_002477213V → L in NSHA; Minnesota; class I. Corresponds to variant dbSNP:rs137852326Ensembl.1
Natural variantiVAR_002478216F → L in NSHA; Harilaou; class I. Corresponds to variant dbSNP:rs137852319Ensembl.1
Natural variantiVAR_002480227R → L in NSHA; A- type 2; class III. Corresponds to variant dbSNP:rs137852328EnsemblClinVar.1
Natural variantiVAR_002481242 – 243Missing in NSHA; Stonybrook; class I. 2
Natural variantiVAR_002482257R → G in NSHA; Wayne; class I. 1
Natural variantiVAR_002483274E → K in NSHA; Corum; class I. 1 Publication1
Natural variantiVAR_002484278S → F in NSHA; Wexham; class I. 1 Publication1
Natural variantiVAR_002485279T → S in NSHA; Chinese-1; class II. 1
Natural variantiVAR_002486282D → H in NSHA; Seattle; class III. 1 PublicationCorresponds to variant dbSNP:rs137852318Ensembl.1
Natural variantiVAR_002487285R → H in NSHA; Montalbano; class III. Corresponds to variant dbSNP:rs74575103Ensembl.1
Natural variantiVAR_002488291V → M in NSHA; Viangchan/Jammu; class II. Corresponds to variant dbSNP:rs137852327Ensembl.1
Natural variantiVAR_002489317E → K in NSHA; Kalyan/Kerala; class III. 1 PublicationCorresponds to variant dbSNP:rs137852339Ensembl.1
Natural variantiVAR_081896321G → V in NSHA; Bhavnagar; decreased enzyme stability. 1 Publication1
Natural variantiVAR_002490323L → P in NSHA; A- type 3; class III. Corresponds to variant dbSNP:rs76723693EnsemblClinVar.1
Natural variantiVAR_002491335A → T in NSHA; Chatham; class III. Corresponds to variant dbSNP:rs5030869Ensembl.1
Natural variantiVAR_002494363N → K in NSHA; Loma Linda; class I. Corresponds to variant dbSNP:rs137852329Ensembl.1
Natural variantiVAR_002495385C → R in NSHA; Tomah; class I. Corresponds to variant dbSNP:rs137852322Ensembl.1
Natural variantiVAR_002496386K → E in NSHA; Iowa; class I. Corresponds to variant dbSNP:rs137852320Ensembl.1
Natural variantiVAR_002498387R → C in NSHA; Guadajalara and Mount Sinai; class I. 2 PublicationsCorresponds to variant dbSNP:rs137852334Ensembl.1
Natural variantiVAR_002497387R → H in NSHA; Beverly Hills; class I. Corresponds to variant dbSNP:rs137852321Ensembl.1
Natural variantiVAR_002499393R → H in NSHA; Nashville/Anaheim; class I. 1 PublicationCorresponds to variant dbSNP:rs137852316Ensembl.1
Natural variantiVAR_002500394V → L in NSHA; Alhambra; class I. 1 PublicationCorresponds to variant dbSNP:rs137852335Ensembl.1
Natural variantiVAR_002501396P → L in NSHA; Bari; class I. 1 PublicationCorresponds to variant dbSNP:rs1557229683EnsemblClinVar.1
Natural variantiVAR_002502398E → K in NSHA; Puerto Limon; class I. Corresponds to variant dbSNP:rs137852325EnsemblClinVar.1
Natural variantiVAR_002503410G → C in NSHA; Riverside; class I. Corresponds to variant dbSNP:rs137852323Ensembl.1
Natural variantiVAR_002504410G → D in NSHA; Japan; class I. 1 PublicationCorresponds to variant dbSNP:rs137852336Ensembl.1
Natural variantiVAR_002505416E → K in NSHA; Tokyo; class I. 1
Natural variantiVAR_002506439R → P in NSHA; Pawnee; class I. 1 PublicationCorresponds to variant dbSNP:rs137852337Ensembl.1
Natural variantiVAR_002507440L → F in NSHA; Telti/Kobe; class I. Corresponds to variant dbSNP:rs1557229599EnsemblClinVar.1
Natural variantiVAR_002508447G → R in NSHA; Santiago de Cuba; class I. Corresponds to variant dbSNP:rs137852317Ensembl.1
Natural variantiVAR_002509449Q → H in NSHA; Cassano; class II. 1
Natural variantiVAR_002510454R → C in NSHA; Chinese-II/Maewo/Union; class II; <1% activity. 1 PublicationCorresponds to variant dbSNP:rs398123546EnsemblClinVar.1
Natural variantiVAR_002511454R → H in NSHA; Andalus; class I. Corresponds to variant dbSNP:rs137852324Ensembl.1
Natural variantiVAR_002512459R → L in NSHA; Canton; class II; frequent in China. Corresponds to variant dbSNP:rs72554665Ensembl.1
Natural variantiVAR_002513459R → P in NSHA; Cosenza; class II. Corresponds to variant dbSNP:rs72554665Ensembl.1
Natural variantiVAR_002515488G → V in NSHA; Campinas; class I. 1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi171K → Q: Inhibits catalytic activity. Does not impair dimerization. 1 Publication1
Mutagenesisi171K → R: Inhibits catalytic activity. Does not impair dimerization. 1 Publication1
Mutagenesisi386K → Q: Impairs dimerization and reduces catalytic activity. 1 Publication1
Mutagenesisi386K → R: Does not impair dimerization and catalytic activity. 1 Publication1
Mutagenesisi403K → Q: Impairs dimerization and reduces catalytic activity in cells under oxidative stress. 1 Publication1
Mutagenesisi403K → R: Does not impair dimerization and catalytic activity. 1 Publication1

Keywords - Diseasei

Disease variant, Hereditary hemolytic anemia

Organism-specific databases

DisGeNET

More...DisGeNETi		2539

MalaCards human disease database

More...MalaCardsi		G6PD
MIMi300908, phenotype

Open Targets

More...OpenTargetsi		ENSG00000160211

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		466026, Class I glucose-6-phosphate dehydrogenase deficiency
362, NON RARE IN EUROPE: Glucose-6-phosphate-dehydrogenase deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA28469

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P11413, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL5347

Drug and drug target database

More...DrugBanki		DB05107, 16-Bromoepiandrosterone
DB11638, Artenimol
DB03085, Glycolic acid
DB03461, Nicotinamide adenine dinucleotide phosphate

DrugCentral

More...DrugCentrali		P11413

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		G6PD

Domain mapping of disease mutations (DMDM)

More...DMDMi		116242483

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources2 Publications
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000680832 – 515Glucose-6-phosphate 1-dehydrogenaseAdd BLAST514

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei8PhosphoserineCombined sources1
Modified residuei10PhosphothreonineCombined sources1
Modified residuei89N6-acetyllysineCombined sources1
Modified residuei171N6-acetyllysineCombined sources1
Modified residuei403N6-acetyllysineCombined sources1 Publication1
Modified residuei432N6-acetyllysineCombined sources1
Modified residuei497N6-acetyllysineCombined sources1
Modified residuei503PhosphotyrosineCombined sources1
Isoform 3 (identifier: P11413-3)
Modified residuei26PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Acetylated by ELP3 at Lys-403; acetylation inhibits its homodimerization and enzyme activity. Deacetylated by SIRT2 at Lys-403; deacetylation stimulates its enzyme activity.2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-204
CPTAC-205

Encyclopedia of Proteome Dynamics

More...EPDi		P11413

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P11413

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P11413

MaxQB - The MaxQuant DataBase

More...MaxQBi		P11413

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P11413

PeptideAtlas

More...PeptideAtlasi		P11413

PRoteomics IDEntifications database

More...PRIDEi		P11413

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		52771 [P11413-1]
52772 [P11413-2]
52773 [P11413-3]

2D gel databases

REPRODUCTION-2DPAGE

More...REPRODUCTION-2DPAGEi		IPI00289800

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...SWISS-2DPAGEi		P11413

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P11413, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P11413

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P11413

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P11413

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P11413

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform Long is found in lymphoblasts, granulocytes and sperm.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000160211, Expressed in blood and 187 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P11413, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P11413, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000160211, Tissue enhanced (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer; dimer of dimers (PubMed:24769394, PubMed:10745013, PubMed:15858258).

Interacts with SIRT2; the interaction is enhanced by H2O2 treatment (PubMed:24769394).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		108814, 108 interactors

Protein interaction database and analysis system

More...IntActi		P11413, 25 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000377192

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P11413

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P11413, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1515
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P11413

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P11413

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni201 – 205Substrate bindingCombined sources1 Publication5

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glucose-6-phosphate dehydrogenase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0563, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00530000063435

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_013524_2_3_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P11413

Identification of Orthologs from Complete Genome Data

More...OMAi		VEICVYE

Database of Orthologous Groups

More...OrthoDBi		383995at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P11413

TreeFam database of animal gene trees

More...TreeFami		TF300584

Family and domain databases

HAMAP database of protein families

More...HAMAPi		MF_00966, G6PD, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001282, G6P_DH
IPR019796, G6P_DH_AS
IPR022675, G6P_DH_C
IPR022674, G6P_DH_NAD-bd
IPR036291, NAD(P)-bd_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR23429, PTHR23429, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02781, G6PD_C, 1 hit
PF00479, G6PD_N, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000110, G6PD, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00079, G6PDHDRGNASE

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF51735, SSF51735, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00871, zwf, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00069, G6P_DEHYDROGENASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform Short (identifier: P11413-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEQVALSRT QVCGILREEL FQGDAFHQSD THIFIIMGAS GDLAKKKIYP 
        60         70         80         90        100
TIWWLFRDGL LPENTFIVGY ARSRLTVADI RKQSEPFFKA TPEEKLKLED 
       110        120        130        140        150
FFARNSYVAG QYDDAASYQR LNSHMNALHL GSQANRLFYL ALPPTVYEAV 
       160        170        180        190        200
TKNIHESCMS QIGWNRIIVE KPFGRDLQSS DRLSNHISSL FREDQIYRID 
       210        220        230        240        250
HYLGKEMVQN LMVLRFANRI FGPIWNRDNI ACVILTFKEP FGTEGRGGYF 
       260        270        280        290        300
DEFGIIRDVM QNHLLQMLCL VAMEKPASTN SDDVRDEKVK VLKCISEVQA 
       310        320        330        340        350
NNVVLGQYVG NPDGEGEATK GYLDDPTVPR GSTTATFAAV VLYVENERWD 
       360        370        380        390        400
GVPFILRCGK ALNERKAEVR LQFHDVAGDI FHQQCKRNEL VIRVQPNEAV 
       410        420        430        440        450
YTKMMTKKPG MFFNPEESEL DLTYGNRYKN VKLPDAYERL ILDVFCGSQM 
       460        470        480        490        500
HFVRSDELRE AWRIFTPLLH QIELEKPKPI PYIYGSRGPT EADELMKRVG 
       510 
FQYEGTYKWV NPHKL
Length:515
Mass (Da):59,257
Last modified:January 23, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF2B775340640A96F
GO
Isoform Long (identifier: P11413-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     257-257: R → RGPGRQGGSGSESCSLSLGSLVWGPHALEPGEQGGELRRALASSVPR

Show »
Length:561
Mass (Da):63,827
Checksum:iA6759ACCB3CDF921
GO
Isoform 3 (identifier: P11413-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGRRGSAPGNGRTLRGCERGGRRRRSADSVM

Show »
Length:545
Mass (Da):62,468
Checksum:iCFE3675547A5672F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EUI8E7EUI8_HUMAN
Glucose-6-phosphate 1-dehydrogenase
G6PD
338Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EM57E7EM57_HUMAN
Glucose-6-phosphate 1-dehydrogenase
G6PD
320Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PD92E9PD92_HUMAN
Glucose-6-phosphate 1-dehydrogenase
G6PD
256Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA63175 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti11Q → H in CAA27309 (PubMed:3515319).Curated1
Sequence conflicti11Q → H in AAA63175 (PubMed:2428611).Curated1
Sequence conflicti11Q → H in AAA52500 (PubMed:2836867).Curated1
Sequence conflicti435 – 436DA → EP in AAA52499 (PubMed:3012556).Curated2

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

The sequence shown is that of variant B, the most common variant.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00245012V → L in Sinnai. 1 Publication1
Natural variantiVAR_00245132H → R in NSHA; Gahoe; class III; frequent in Chinese. 1 PublicationCorresponds to variant dbSNP:rs137852340Ensembl.1
Natural variantiVAR_00245235Missing in NSHA; Sunderland; class I. 1
Natural variantiVAR_00245344A → G in NSHA; Orissa; class III; frequent in Indian tribal populations. 1 PublicationCorresponds to variant dbSNP:rs78478128Ensembl.1
Natural variantiVAR_00245448I → T in NSHA; Aures; class II. 1 PublicationCorresponds to variant dbSNP:rs76645461Ensembl.1
Natural variantiVAR_00245558D → N in NSHA; Metaponto; class III. Corresponds to variant dbSNP:rs137852315Ensembl.1
Natural variantiVAR_00245668V → M in NSHA; A(-) type I; class III; frequent in African population. 4 PublicationsCorresponds to variant dbSNP:rs1050828Ensembl.1
Natural variantiVAR_00245770Y → H in NSHA; Namoru; 4% activity. Corresponds to variant dbSNP:rs137852349Ensembl.1
Natural variantiVAR_00245875L → P in NSHA; Swansea; class I. 1 Publication1
Natural variantiVAR_00246081R → C in NSHA; Konan/Ube; class III. Corresponds to variant dbSNP:rs138687036Ensembl.1
Natural variantiVAR_00245981R → H in NSHA; Lagosanto; class III. Corresponds to variant dbSNP:rs782308266Ensembl.1
Natural variantiVAR_002461106S → C in NSHA; Vancouver; class I. Corresponds to variant dbSNP:rs267606835EnsemblClinVar.1
Natural variantiVAR_002462126N → D Found in Santa Maria and Mount Sinai; associated with C-387 in Mount Sinai; class IV and class I. 7 PublicationsCorresponds to variant dbSNP:rs1050829Ensembl.1
Natural variantiVAR_002463128L → P in NSHA; Vanua Lava; 4% activity. Corresponds to variant dbSNP:rs78365220EnsemblClinVar.1
Natural variantiVAR_002464131G → V in Chinese-4. Corresponds to variant dbSNP:rs137852341Ensembl.1
Natural variantiVAR_002465156E → K in NSHA; Ilesha; class III. Corresponds to variant dbSNP:rs137852313Ensembl.1
Natural variantiVAR_002467163G → D in NSHA; Plymouth; class I. 1 Publication1
Natural variantiVAR_002466163G → S in NSHA; Mahidol; class III; associated with reduced density of Plasmodium vivax but not Plasmodium falciparum in Southeast Asians; reduced activity. Corresponds to variant dbSNP:rs137852314Ensembl.1
Natural variantiVAR_002468165N → D in NSHA; Chinese-3; class II. Corresponds to variant dbSNP:rs137852331Ensembl.1
Natural variantiVAR_002469166R → H in NSHA; Naone; 1% activity. 1
Natural variantiVAR_002470176D → G in NSHA; Shinshu; class I. 1 Publication1
Natural variantiVAR_002471181D → V in NSHA; Santa Maria; class I. Corresponds to variant dbSNP:rs5030872Ensembl.1
Natural variantiVAR_002472182R → W in NSHA; Vancouver; class I. Corresponds to variant dbSNP:rs267606836EnsemblClinVar.1
Natural variantiVAR_081894184S → F in Dindori; class II; 5% of activity. 1 PublicationCorresponds to variant dbSNP:rs782315572Ensembl.1
Natural variantiVAR_002473188S → F in NSHA; Sassari/Cagliari; class II; frequent in the Mediterranean. 1 PublicationCorresponds to variant dbSNP:rs5030868Ensembl.1
Natural variantiVAR_002474198R → C in Coimbra; class II. 1 PublicationCorresponds to variant dbSNP:rs137852330Ensembl.1
Natural variantiVAR_081895198R → H in Nilgiris; class II. 2 PublicationsCorresponds to variant dbSNP:rs137852332Ensembl.1
Natural variantiVAR_002475198R → P in NSHA; Santiago; class I. 1 PublicationCorresponds to variant dbSNP:rs137852332Ensembl.1
Natural variantiVAR_075555198R → S in NSHA; Herlev; loss of glucose-6-phosphate dehydrogenase activity. 1 Publication1
Natural variantiVAR_002476212M → V in NSHA; Sibari; class III. Corresponds to variant dbSNP:rs782754619Ensembl.1
Natural variantiVAR_002477213V → L in NSHA; Minnesota; class I. Corresponds to variant dbSNP:rs137852326Ensembl.1
Natural variantiVAR_002478216F → L in NSHA; Harilaou; class I. Corresponds to variant dbSNP:rs137852319Ensembl.1
Natural variantiVAR_002480227R → L in NSHA; A- type 2; class III. Corresponds to variant dbSNP:rs137852328EnsemblClinVar.1
Natural variantiVAR_002479227R → Q in Mexico City; class III. 1 PublicationCorresponds to variant dbSNP:rs137852328EnsemblClinVar.1
Natural variantiVAR_002481242 – 243Missing in NSHA; Stonybrook; class I. 2
Natural variantiVAR_002482257R → G in NSHA; Wayne; class I. 1
Natural variantiVAR_002483274E → K in NSHA; Corum; class I. 1 Publication1
Natural variantiVAR_002484278S → F in NSHA; Wexham; class I. 1 Publication1
Natural variantiVAR_002485279T → S in NSHA; Chinese-1; class II. 1
Natural variantiVAR_002486282D → H in NSHA; Seattle; class III. 1 PublicationCorresponds to variant dbSNP:rs137852318Ensembl.1
Natural variantiVAR_002487285R → H in NSHA; Montalbano; class III. Corresponds to variant dbSNP:rs74575103Ensembl.1
Natural variantiVAR_002488291V → M in NSHA; Viangchan/Jammu; class II. Corresponds to variant dbSNP:rs137852327Ensembl.1
Natural variantiVAR_002489317E → K in NSHA; Kalyan/Kerala; class III. 1 PublicationCorresponds to variant dbSNP:rs137852339Ensembl.1
Natural variantiVAR_081896321G → V in NSHA; Bhavnagar; decreased enzyme stability. 1 Publication1
Natural variantiVAR_020535322Y → H in Rehovot. 1 PublicationCorresponds to variant dbSNP:rs137852347Ensembl.1
Natural variantiVAR_002490323L → P in NSHA; A- type 3; class III. Corresponds to variant dbSNP:rs76723693EnsemblClinVar.1
Natural variantiVAR_002491335A → T in NSHA; Chatham; class III. Corresponds to variant dbSNP:rs5030869Ensembl.1
Natural variantiVAR_002492342L → F in Chinese-5. Corresponds to variant dbSNP:rs137852342Ensembl.1
Natural variantiVAR_002493353P → S in Ierapetra; class II. 1 PublicationCorresponds to variant dbSNP:rs137852333Ensembl.1
Natural variantiVAR_002494363N → K in NSHA; Loma Linda; class I. Corresponds to variant dbSNP:rs137852329Ensembl.1
Natural variantiVAR_002495385C → R in NSHA; Tomah; class I. Corresponds to variant dbSNP:rs137852322Ensembl.1
Natural variantiVAR_002496386K → E in NSHA; Iowa; class I. Corresponds to variant dbSNP:rs137852320Ensembl.1
Natural variantiVAR_002498387R → C in NSHA; Guadajalara and Mount Sinai; class I. 2 PublicationsCorresponds to variant dbSNP:rs137852334Ensembl.1
Natural variantiVAR_002497387R → H in NSHA; Beverly Hills; class I. Corresponds to variant dbSNP:rs137852321Ensembl.1
Natural variantiVAR_002499393R → H in NSHA; Nashville/Anaheim; class I. 1 PublicationCorresponds to variant dbSNP:rs137852316Ensembl.1
Natural variantiVAR_002500394V → L in NSHA; Alhambra; class I. 1 PublicationCorresponds to variant dbSNP:rs137852335Ensembl.1
Natural variantiVAR_002501396P → L in NSHA; Bari; class I. 1 PublicationCorresponds to variant dbSNP:rs1557229683EnsemblClinVar.1
Natural variantiVAR_002502398E → K in NSHA; Puerto Limon; class I. Corresponds to variant dbSNP:rs137852325EnsemblClinVar.1
Natural variantiVAR_002503410G → C in NSHA; Riverside; class I. Corresponds to variant dbSNP:rs137852323Ensembl.1
Natural variantiVAR_002504410G → D in NSHA; Japan; class I. 1 PublicationCorresponds to variant dbSNP:rs137852336Ensembl.1
Natural variantiVAR_002505416E → K in NSHA; Tokyo; class I. 1
Natural variantiVAR_002506439R → P in NSHA; Pawnee; class I. 1 PublicationCorresponds to variant dbSNP:rs137852337Ensembl.1
Natural variantiVAR_002507440L → F in NSHA; Telti/Kobe; class I. Corresponds to variant dbSNP:rs1557229599EnsemblClinVar.1
Natural variantiVAR_002508447G → R in NSHA; Santiago de Cuba; class I. Corresponds to variant dbSNP:rs137852317Ensembl.1
Natural variantiVAR_002509449Q → H in NSHA; Cassano; class II. 1
Natural variantiVAR_002510454R → C in NSHA; Chinese-II/Maewo/Union; class II; <1% activity. 1 PublicationCorresponds to variant dbSNP:rs398123546EnsemblClinVar.1
Natural variantiVAR_002511454R → H in NSHA; Andalus; class I. Corresponds to variant dbSNP:rs137852324Ensembl.1
Natural variantiVAR_002512459R → L in NSHA; Canton; class II; frequent in China. Corresponds to variant dbSNP:rs72554665Ensembl.1
Natural variantiVAR_002513459R → P in NSHA; Cosenza; class II. Corresponds to variant dbSNP:rs72554665Ensembl.1
Natural variantiVAR_002514463R → H in Kaiping; class II. 1 PublicationCorresponds to variant dbSNP:rs72554664Ensembl.1
Natural variantiVAR_002515488G → V in NSHA; Campinas; class I. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0378021M → MGRRGSAPGNGRTLRGCERG GRRRRSADSVM in isoform 3. 1 Publication1
Alternative sequenceiVSP_001592257R → RGPGRQGGSGSESCSLSLGS LVWGPHALEPGEQGGELRRA LASSVPR in isoform Long. Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X03674 mRNA Translation: CAA27309.1
M65234 M65232 Genomic DNA Translation: AAA63175.1 Different initiation.
M21248 mRNA Translation: AAA52500.1
M19866 mRNA Translation: AAA52501.1
X55448 Genomic DNA Translation: CAA39089.1
L44140 Genomic DNA Translation: AAA92653.1
AF277315 Genomic DNA Translation: AAL27011.1
CH471172 Genomic DNA Translation: EAW72682.1
CH471172 Genomic DNA Translation: EAW72686.1
BC000337 mRNA Translation: AAH00337.1
M27940 mRNA Translation: AAA52504.1
S58359 mRNA Translation: AAB26169.1
X53815 Genomic DNA Translation: CAA37811.1
S64462 Genomic DNA Translation: AAB20299.1
AY158096 Genomic DNA Translation: AAN76367.1
AY158097 Genomic DNA Translation: AAN76368.1
AY158098 Genomic DNA Translation: AAN76369.1
AY158099 Genomic DNA Translation: AAN76370.1
AY158100 Genomic DNA Translation: AAN76371.1
AY158101 Genomic DNA Translation: AAN76372.1
AY158102 Genomic DNA Translation: AAN76373.1
AY158103 Genomic DNA Translation: AAN76374.1
AY158104 Genomic DNA Translation: AAN76375.1
AY158105 Genomic DNA Translation: AAN76376.1
AY158106 Genomic DNA Translation: AAN76377.1
AY158107 Genomic DNA Translation: AAN76378.1
AY158108 Genomic DNA Translation: AAN76379.1
AY158109 Genomic DNA Translation: AAN76380.1
AY158110 Genomic DNA Translation: AAN76381.1
AY158111 Genomic DNA Translation: AAN76382.1
AY158112 Genomic DNA Translation: AAN76383.1
AY158113 Genomic DNA Translation: AAN76384.1
AY158114 Genomic DNA Translation: AAN76385.1
AY158115 Genomic DNA Translation: AAN76386.1
AY158116 Genomic DNA Translation: AAN76387.1
AY158117 Genomic DNA Translation: AAN76388.1
AY158118 Genomic DNA Translation: AAN76389.1
AY158119 Genomic DNA Translation: AAN76390.1
AY158120 Genomic DNA Translation: AAN76391.1
AY158121 Genomic DNA Translation: AAN76392.1
AY158122 Genomic DNA Translation: AAN76393.1
AY158123 Genomic DNA Translation: AAN76394.1
AY158124 Genomic DNA Translation: AAN76395.1
AY158125 Genomic DNA Translation: AAN76396.1
AY158126 Genomic DNA Translation: AAN76397.1
AY158127 Genomic DNA Translation: AAN76398.1
AY158128 Genomic DNA Translation: AAN76399.1
AY158129 Genomic DNA Translation: AAN76400.1
AY158130 Genomic DNA Translation: AAN76401.1
AY158131 Genomic DNA Translation: AAN76402.1
AY158132 Genomic DNA Translation: AAN76403.1
AY158133 Genomic DNA Translation: AAN76404.1
AY158134 Genomic DNA Translation: AAN76405.1
AY158135 Genomic DNA Translation: AAN76406.1
AY158136 Genomic DNA Translation: AAN76407.1
AY158137 Genomic DNA Translation: AAN76408.1
AY158138 Genomic DNA Translation: AAN76409.1
AY158139 Genomic DNA Translation: AAN76410.1
AY158140 Genomic DNA Translation: AAN76411.1
AY158141 Genomic DNA Translation: AAN76412.1
AY158142 Genomic DNA Translation: AAN76413.1
M12996 mRNA Translation: AAA52499.1
M23423 Genomic DNA Translation: AAB59390.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS44023.1 [P11413-1]

Protein sequence database of the Protein Information Resource

More...PIRi		A40309, DEHUG6

NCBI Reference Sequences

More...RefSeqi		NP_000393.4, NM_000402.4 [P11413-3]
NP_001035810.1, NM_001042351.2 [P11413-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000369620; ENSP00000358633; ENSG00000160211 [P11413-2]
ENST00000393562; ENSP00000377192; ENSG00000160211 [P11413-1]
ENST00000393564; ENSP00000377194; ENSG00000160211 [P11413-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2539

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:2539

UCSC genome browser

More...UCSCi		uc004flx.3, human [P11413-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

G6PDdb

G6PD mutation database

SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03674 mRNA Translation: CAA27309.1
M65234 M65232 Genomic DNA Translation: AAA63175.1 Different initiation.
M21248 mRNA Translation: AAA52500.1
M19866 mRNA Translation: AAA52501.1
X55448 Genomic DNA Translation: CAA39089.1
L44140 Genomic DNA Translation: AAA92653.1
AF277315 Genomic DNA Translation: AAL27011.1
CH471172 Genomic DNA Translation: EAW72682.1
CH471172 Genomic DNA Translation: EAW72686.1
BC000337 mRNA Translation: AAH00337.1
M27940 mRNA Translation: AAA52504.1
S58359 mRNA Translation: AAB26169.1
X53815 Genomic DNA Translation: CAA37811.1
S64462 Genomic DNA Translation: AAB20299.1
AY158096 Genomic DNA Translation: AAN76367.1
AY158097 Genomic DNA Translation: AAN76368.1
AY158098 Genomic DNA Translation: AAN76369.1
AY158099 Genomic DNA Translation: AAN76370.1
AY158100 Genomic DNA Translation: AAN76371.1
AY158101 Genomic DNA Translation: AAN76372.1
AY158102 Genomic DNA Translation: AAN76373.1
AY158103 Genomic DNA Translation: AAN76374.1
AY158104 Genomic DNA Translation: AAN76375.1
AY158105 Genomic DNA Translation: AAN76376.1
AY158106 Genomic DNA Translation: AAN76377.1
AY158107 Genomic DNA Translation: AAN76378.1
AY158108 Genomic DNA Translation: AAN76379.1
AY158109 Genomic DNA Translation: AAN76380.1
AY158110 Genomic DNA Translation: AAN76381.1
AY158111 Genomic DNA Translation: AAN76382.1
AY158112 Genomic DNA Translation: AAN76383.1
AY158113 Genomic DNA Translation: AAN76384.1
AY158114 Genomic DNA Translation: AAN76385.1
AY158115 Genomic DNA Translation: AAN76386.1
AY158116 Genomic DNA Translation: AAN76387.1
AY158117 Genomic DNA Translation: AAN76388.1
AY158118 Genomic DNA Translation: AAN76389.1
AY158119 Genomic DNA Translation: AAN76390.1
AY158120 Genomic DNA Translation: AAN76391.1
AY158121 Genomic DNA Translation: AAN76392.1
AY158122 Genomic DNA Translation: AAN76393.1
AY158123 Genomic DNA Translation: AAN76394.1
AY158124 Genomic DNA Translation: AAN76395.1
AY158125 Genomic DNA Translation: AAN76396.1
AY158126 Genomic DNA Translation: AAN76397.1
AY158127 Genomic DNA Translation: AAN76398.1
AY158128 Genomic DNA Translation: AAN76399.1
AY158129 Genomic DNA Translation: AAN76400.1
AY158130 Genomic DNA Translation: AAN76401.1
AY158131 Genomic DNA Translation: AAN76402.1
AY158132 Genomic DNA Translation: AAN76403.1
AY158133 Genomic DNA Translation: AAN76404.1
AY158134 Genomic DNA Translation: AAN76405.1
AY158135 Genomic DNA Translation: AAN76406.1
AY158136 Genomic DNA Translation: AAN76407.1
AY158137 Genomic DNA Translation: AAN76408.1
AY158138 Genomic DNA Translation: AAN76409.1
AY158139 Genomic DNA Translation: AAN76410.1
AY158140 Genomic DNA Translation: AAN76411.1
AY158141 Genomic DNA Translation: AAN76412.1
AY158142 Genomic DNA Translation: AAN76413.1
M12996 mRNA Translation: AAA52499.1
M23423 Genomic DNA Translation: AAB59390.1
CCDSiCCDS44023.1 [P11413-1]
PIRiA40309, DEHUG6
RefSeqiNP_000393.4, NM_000402.4 [P11413-3]
NP_001035810.1, NM_001042351.2 [P11413-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QKIX-ray3.00A/B/C/D/E/F/G/H2-515[»]
2BH9X-ray2.50A27-515[»]
2BHLX-ray2.90A/B28-515[»]
5UKWX-ray2.65A29-511[»]
6E07X-ray2.60B/C/F/L/N/Q/T/W1-515[»]
6E08X-ray1.90L1-515[»]
6JYUX-ray1.89A29-513[»]
6VA0X-ray3.10A1-515[»]
6VA7X-ray3.07A1-515[»]
6VA8X-ray3.95A1-515[»]
6VA9X-ray3.95A1-515[»]
6VAQX-ray2.95A1-515[»]
SMRiP11413
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi108814, 108 interactors
IntActiP11413, 25 interactors
STRINGi9606.ENSP00000377192

Chemistry databases

BindingDBiP11413
ChEMBLiCHEMBL5347
DrugBankiDB05107, 16-Bromoepiandrosterone
DB11638, Artenimol
DB03085, Glycolic acid
DB03461, Nicotinamide adenine dinucleotide phosphate
DrugCentraliP11413

PTM databases

GlyGeniP11413, 1 site, 1 O-linked glycan (1 site)
iPTMnetiP11413
MetOSiteiP11413
PhosphoSitePlusiP11413
SwissPalmiP11413

Genetic variation databases

BioMutaiG6PD
DMDMi116242483

2D gel databases

REPRODUCTION-2DPAGEiIPI00289800
SWISS-2DPAGEiP11413

Proteomic databases

CPTACiCPTAC-204
CPTAC-205
EPDiP11413
jPOSTiP11413
MassIVEiP11413
MaxQBiP11413
PaxDbiP11413
PeptideAtlasiP11413
PRIDEiP11413
ProteomicsDBi52771 [P11413-1]
52772 [P11413-2]
52773 [P11413-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		352, 741 antibodies

The DNASU plasmid repository

More...DNASUi		2539

Genome annotation databases

EnsembliENST00000369620; ENSP00000358633; ENSG00000160211 [P11413-2]
ENST00000393562; ENSP00000377192; ENSG00000160211 [P11413-1]
ENST00000393564; ENSP00000377194; ENSG00000160211 [P11413-1]
GeneIDi2539
KEGGihsa:2539
UCSCiuc004flx.3, human [P11413-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2539
DisGeNETi2539

GeneCards: human genes, protein and diseases

More...GeneCardsi		G6PD
HGNCiHGNC:4057, G6PD
HPAiENSG00000160211, Tissue enhanced (testis)
MalaCardsiG6PD
MIMi300908, phenotype
305900, gene
neXtProtiNX_P11413
OpenTargetsiENSG00000160211
Orphaneti466026, Class I glucose-6-phosphate dehydrogenase deficiency
362, NON RARE IN EUROPE: Glucose-6-phosphate-dehydrogenase deficiency
PharmGKBiPA28469
VEuPathDBiHostDB:ENSG00000160211

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0563, Eukaryota
GeneTreeiENSGT00530000063435
HOGENOMiCLU_013524_2_3_1
InParanoidiP11413
OMAiVEICVYE
OrthoDBi383995at2759
PhylomeDBiP11413
TreeFamiTF300584

Enzyme and pathway databases

UniPathwayiUPA00115;UER00408
BioCyciMetaCyc:HS08467-MONOMER
BRENDAi1.1.1.49, 2681
PathwayCommonsiP11413
ReactomeiR-HSA-5628897, TP53 Regulates Metabolic Genes
R-HSA-71336, Pentose phosphate pathway
SABIO-RKiP11413
SIGNORiP11413

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		2539, 59 hits in 656 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		G6PD, human
EvolutionaryTraceiP11413

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Glucose-6-phosphate_dehydrogenase

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		2539
PharosiP11413, Tchem

Protein Ontology

More...PROi		PR:P11413
RNActiP11413, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000160211, Expressed in blood and 187 other tissues
ExpressionAtlasiP11413, baseline and differential
GenevisibleiP11413, HS

Family and domain databases

HAMAPiMF_00966, G6PD, 1 hit
InterProiView protein in InterPro
IPR001282, G6P_DH
IPR019796, G6P_DH_AS
IPR022675, G6P_DH_C
IPR022674, G6P_DH_NAD-bd
IPR036291, NAD(P)-bd_dom_sf
PANTHERiPTHR23429, PTHR23429, 1 hit
PfamiView protein in Pfam
PF02781, G6PD_C, 1 hit
PF00479, G6PD_N, 1 hit
PIRSFiPIRSF000110, G6PD, 1 hit
PRINTSiPR00079, G6PDHDRGNASE
SUPFAMiSSF51735, SSF51735, 1 hit
TIGRFAMsiTIGR00871, zwf, 1 hit
PROSITEiView protein in PROSITE
PS00069, G6P_DEHYDROGENASE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG6PD_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P11413
Secondary accession number(s): D3DWX9
, Q16000, Q16765, Q8IU70, Q8IU88, Q8IUA6, Q96PQ2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 23, 2007
Last modified: September 29, 2021
This is version 258 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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