UniProtKB - P11413 (G6PD_HUMAN)
Glucose-6-phosphate 1-dehydrogenase
G6PD
Functioni
Miscellaneous
Catalytic activityi
Kineticsi
- KM=7.07 µM for NADP1 Publication
- KM=52 µM for glucose 6-phosphate1 Publication
: pentose phosphate pathway Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).4 PublicationsProteins known to be involved in the 3 steps of the subpathway in this organism are:
- Glucose-6-phosphate 1-dehydrogenase (G6PD), Glucose-6-phosphate 1-dehydrogenase, GDH/6PGL endoplasmic bifunctional protein (H6PD), Glucose-6-phosphate 1-dehydrogenase (G6PD), Glucose-6-phosphate 1-dehydrogenase (G6PD), Glucose-6-phosphate 1-dehydrogenase (G6PD), Glucose-6-phosphate 1-dehydrogenase, Glucose-6-phosphate 1-dehydrogenase (G6PD), Glucose-6-phosphate 1-dehydrogenase, Glucose-6-phosphate 1-dehydrogenase (G6PD), Glucose-6-phosphate 1-dehydrogenase, Glucose-6-phosphate 1-dehydrogenase (G6PD)
- 6-phosphogluconolactonase (PGLS), 6-phosphogluconolactonase (HEL-S-304), GDH/6PGL endoplasmic bifunctional protein (H6PD), 6-phosphogluconolactonase (PGLS), 6-phosphogluconolactonase (PGLS)
- 6-phosphogluconate dehydrogenase, decarboxylating, Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating) (PGD), 6-phosphogluconate dehydrogenase, decarboxylating, 6-phosphogluconate dehydrogenase, decarboxylating (PGD), Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating) (PGD), Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating), Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating) (PGD), Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 72 | NADP 1Combined sources2 Publications | 1 | |
Binding sitei | 147 | NADP 1Combined sources2 Publications | 1 | |
Binding sitei | 171 | NADP 1; via carbonyl oxygenCombined sources2 Publications | 1 | |
Binding sitei | 171 | SubstrateCombined sources1 Publication | 1 | |
Binding sitei | 239 | SubstrateCombined sources1 Publication | 1 | |
Binding sitei | 258 | SubstrateCombined sources1 Publication | 1 | |
Active sitei | 263 | Proton acceptorBy similarity | 1 | |
Binding sitei | 357 | NADP 2Combined sources2 Publications | 1 | |
Binding sitei | 360 | SubstrateCombined sources1 Publication | 1 | |
Binding sitei | 365 | SubstrateCombined sources1 Publication | 1 | |
Binding sitei | 366 | NADP 2Combined sources2 Publications | 1 | |
Binding sitei | 370 | NADP 2Combined sources2 Publications | 1 | |
Binding sitei | 393 | NADP 2Combined sources2 Publications | 1 | |
Binding sitei | 395 | SubstrateCombined sources1 Publication | 1 | |
Binding sitei | 487 | NADP 2Combined sources2 Publications | 1 | |
Binding sitei | 503 | NADP 2Combined sources2 Publications | 1 | |
Binding sitei | 509 | NADP 2Combined sources2 Publications | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 38 – 45 | NADP 1Combined sources2 Publications | 8 | |
Nucleotide bindingi | 401 – 403 | NADP 2Combined sources2 Publications | 3 | |
Nucleotide bindingi | 421 – 423 | NADP 2Combined sources2 Publications | 3 |
GO - Molecular functioni
- glucose-6-phosphate dehydrogenase activity Source: UniProtKB
- glucose binding Source: BHF-UCL
- identical protein binding Source: IntAct
- NADP binding Source: BHF-UCL
- protein homodimerization activity Source: BHF-UCL
GO - Biological processi
- cellular response to oxidative stress Source: BHF-UCL
- cholesterol biosynthetic process Source: BHF-UCL
- erythrocyte maturation Source: BHF-UCL
- glucose 6-phosphate metabolic process Source: UniProtKB
- glucose metabolic process Source: UniProtKB-KW
- glutathione metabolic process Source: BHF-UCL
- lipid metabolic process Source: BHF-UCL
- NADPH regeneration Source: BHF-UCL
- NADP metabolic process Source: UniProtKB
- negative regulation of cell growth involved in cardiac muscle cell development Source: Ensembl
- negative regulation of protein glutathionylation Source: BHF-UCL
- negative regulation of reactive oxygen species metabolic process Source: Ensembl
- pentose biosynthetic process Source: BHF-UCL
- pentose-phosphate shunt Source: BHF-UCL
- pentose-phosphate shunt, oxidative branch Source: BHF-UCL
- positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel Source: Ensembl
- regulation of neuron apoptotic process Source: Ensembl
- response to ethanol Source: Ensembl
- response to food Source: Ensembl
- response to iron(III) ion Source: Ensembl
- response to organic cyclic compound Source: Ensembl
- ribose phosphate biosynthetic process Source: BHF-UCL
- substantia nigra development Source: UniProtKB
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Carbohydrate metabolism, Glucose metabolism |
Ligand | NADP |
Enzyme and pathway databases
BioCyci | MetaCyc:HS08467-MONOMER |
BRENDAi | 1.1.1.49, 2681 |
PathwayCommonsi | P11413 |
Reactomei | R-HSA-5628897, TP53 Regulates Metabolic Genes R-HSA-71336, Pentose phosphate pathway |
SABIO-RKi | P11413 |
SIGNORi | P11413 |
UniPathwayi | UPA00115;UER00408 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:G6PD |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4057, G6PD |
MIMi | 305900, gene |
neXtProti | NX_P11413 |
VEuPathDBi | HostDB:ENSG00000160211.15 |
Subcellular locationi
Cytoplasm and Cytosol
- cytosol 1 Publication
Other locations
- Membrane ; Peripheral membrane protein 1 Publication
Cytoskeleton
- centriolar satellite Source: HPA
Cytosol
- cytosol Source: BHF-UCL
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nucleus Source: Ensembl
Plasma Membrane
- cytoplasmic side of plasma membrane Source: BHF-UCL
Other locations
- cytoplasm Source: LIFEdb
- intracellular membrane-bounded organelle Source: HPA
- membrane Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, MembranePathology & Biotechi
Involvement in diseasei
Anemia, non-spherocytic hemolytic, due to G6PD deficiency (NSHA)19 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_002451 | 32 | H → R in NSHA; Gahoe; class III; frequent in Chinese. 1 PublicationCorresponds to variant dbSNP:rs137852340Ensembl. | 1 | |
Natural variantiVAR_002452 | 35 | Missing in NSHA; Sunderland; class I. | 1 | |
Natural variantiVAR_002453 | 44 | A → G in NSHA; Orissa; class III; frequent in Indian tribal populations. 1 PublicationCorresponds to variant dbSNP:rs78478128Ensembl. | 1 | |
Natural variantiVAR_002454 | 48 | I → T in NSHA; Aures; class II. 1 PublicationCorresponds to variant dbSNP:rs76645461Ensembl. | 1 | |
Natural variantiVAR_002455 | 58 | D → N in NSHA; Metaponto; class III. Corresponds to variant dbSNP:rs137852315Ensembl. | 1 | |
Natural variantiVAR_002456 | 68 | V → M in NSHA; A(-) type I; class III; frequent in African population. 4 PublicationsCorresponds to variant dbSNP:rs1050828Ensembl. | 1 | |
Natural variantiVAR_002457 | 70 | Y → H in NSHA; Namoru; 4% activity. Corresponds to variant dbSNP:rs137852349Ensembl. | 1 | |
Natural variantiVAR_002458 | 75 | L → P in NSHA; Swansea; class I. 1 Publication | 1 | |
Natural variantiVAR_002460 | 81 | R → C in NSHA; Konan/Ube; class III. Corresponds to variant dbSNP:rs138687036Ensembl. | 1 | |
Natural variantiVAR_002459 | 81 | R → H in NSHA; Lagosanto; class III. Corresponds to variant dbSNP:rs782308266Ensembl. | 1 | |
Natural variantiVAR_002461 | 106 | S → C in NSHA; Vancouver; class I. Corresponds to variant dbSNP:rs267606835EnsemblClinVar. | 1 | |
Natural variantiVAR_002463 | 128 | L → P in NSHA; Vanua Lava; 4% activity. Corresponds to variant dbSNP:rs78365220EnsemblClinVar. | 1 | |
Natural variantiVAR_002465 | 156 | E → K in NSHA; Ilesha; class III. Corresponds to variant dbSNP:rs137852313Ensembl. | 1 | |
Natural variantiVAR_002467 | 163 | G → D in NSHA; Plymouth; class I. 1 Publication | 1 | |
Natural variantiVAR_002466 | 163 | G → S in NSHA; Mahidol; class III; associated with reduced density of Plasmodium vivax but not Plasmodium falciparum in Southeast Asians; reduced activity. Corresponds to variant dbSNP:rs137852314Ensembl. | 1 | |
Natural variantiVAR_002468 | 165 | N → D in NSHA; Chinese-3; class II. Corresponds to variant dbSNP:rs137852331Ensembl. | 1 | |
Natural variantiVAR_002469 | 166 | R → H in NSHA; Naone; 1% activity. | 1 | |
Natural variantiVAR_002470 | 176 | D → G in NSHA; Shinshu; class I. 1 Publication | 1 | |
Natural variantiVAR_002471 | 181 | D → V in NSHA; Santa Maria; class I. Corresponds to variant dbSNP:rs5030872Ensembl. | 1 | |
Natural variantiVAR_002472 | 182 | R → W in NSHA; Vancouver; class I. Corresponds to variant dbSNP:rs267606836EnsemblClinVar. | 1 | |
Natural variantiVAR_002473 | 188 | S → F in NSHA; Sassari/Cagliari; class II; frequent in the Mediterranean. 1 PublicationCorresponds to variant dbSNP:rs5030868Ensembl. | 1 | |
Natural variantiVAR_002475 | 198 | R → P in NSHA; Santiago; class I. 1 PublicationCorresponds to variant dbSNP:rs137852332Ensembl. | 1 | |
Natural variantiVAR_075555 | 198 | R → S in NSHA; Herlev; loss of glucose-6-phosphate dehydrogenase activity. 1 Publication | 1 | |
Natural variantiVAR_002476 | 212 | M → V in NSHA; Sibari; class III. Corresponds to variant dbSNP:rs782754619Ensembl. | 1 | |
Natural variantiVAR_002477 | 213 | V → L in NSHA; Minnesota; class I. Corresponds to variant dbSNP:rs137852326Ensembl. | 1 | |
Natural variantiVAR_002478 | 216 | F → L in NSHA; Harilaou; class I. Corresponds to variant dbSNP:rs137852319Ensembl. | 1 | |
Natural variantiVAR_002480 | 227 | R → L in NSHA; A- type 2; class III. Corresponds to variant dbSNP:rs137852328EnsemblClinVar. | 1 | |
Natural variantiVAR_002481 | 242 – 243 | Missing in NSHA; Stonybrook; class I. | 2 | |
Natural variantiVAR_002482 | 257 | R → G in NSHA; Wayne; class I. | 1 | |
Natural variantiVAR_002483 | 274 | E → K in NSHA; Corum; class I. 1 Publication | 1 | |
Natural variantiVAR_002484 | 278 | S → F in NSHA; Wexham; class I. 1 Publication | 1 | |
Natural variantiVAR_002485 | 279 | T → S in NSHA; Chinese-1; class II. | 1 | |
Natural variantiVAR_002486 | 282 | D → H in NSHA; Seattle; class III. 1 PublicationCorresponds to variant dbSNP:rs137852318Ensembl. | 1 | |
Natural variantiVAR_002487 | 285 | R → H in NSHA; Montalbano; class III. Corresponds to variant dbSNP:rs74575103Ensembl. | 1 | |
Natural variantiVAR_002488 | 291 | V → M in NSHA; Viangchan/Jammu; class II. Corresponds to variant dbSNP:rs137852327Ensembl. | 1 | |
Natural variantiVAR_002489 | 317 | E → K in NSHA; Kalyan/Kerala; class III. 1 PublicationCorresponds to variant dbSNP:rs137852339Ensembl. | 1 | |
Natural variantiVAR_081896 | 321 | G → V in NSHA; Bhavnagar; decreased enzyme stability. 1 Publication | 1 | |
Natural variantiVAR_002490 | 323 | L → P in NSHA; A- type 3; class III. Corresponds to variant dbSNP:rs76723693EnsemblClinVar. | 1 | |
Natural variantiVAR_002491 | 335 | A → T in NSHA; Chatham; class III. Corresponds to variant dbSNP:rs5030869Ensembl. | 1 | |
Natural variantiVAR_002494 | 363 | N → K in NSHA; Loma Linda; class I. Corresponds to variant dbSNP:rs137852329Ensembl. | 1 | |
Natural variantiVAR_002495 | 385 | C → R in NSHA; Tomah; class I. Corresponds to variant dbSNP:rs137852322Ensembl. | 1 | |
Natural variantiVAR_002496 | 386 | K → E in NSHA; Iowa; class I. Corresponds to variant dbSNP:rs137852320Ensembl. | 1 | |
Natural variantiVAR_002498 | 387 | R → C in NSHA; Guadajalara and Mount Sinai; class I. 2 PublicationsCorresponds to variant dbSNP:rs137852334Ensembl. | 1 | |
Natural variantiVAR_002497 | 387 | R → H in NSHA; Beverly Hills; class I. Corresponds to variant dbSNP:rs137852321Ensembl. | 1 | |
Natural variantiVAR_002499 | 393 | R → H in NSHA; Nashville/Anaheim; class I. 1 PublicationCorresponds to variant dbSNP:rs137852316Ensembl. | 1 | |
Natural variantiVAR_002500 | 394 | V → L in NSHA; Alhambra; class I. 1 PublicationCorresponds to variant dbSNP:rs137852335Ensembl. | 1 | |
Natural variantiVAR_002501 | 396 | P → L in NSHA; Bari; class I. 1 PublicationCorresponds to variant dbSNP:rs1557229683EnsemblClinVar. | 1 | |
Natural variantiVAR_002502 | 398 | E → K in NSHA; Puerto Limon; class I. Corresponds to variant dbSNP:rs137852325EnsemblClinVar. | 1 | |
Natural variantiVAR_002503 | 410 | G → C in NSHA; Riverside; class I. Corresponds to variant dbSNP:rs137852323Ensembl. | 1 | |
Natural variantiVAR_002504 | 410 | G → D in NSHA; Japan; class I. 1 PublicationCorresponds to variant dbSNP:rs137852336Ensembl. | 1 | |
Natural variantiVAR_002505 | 416 | E → K in NSHA; Tokyo; class I. | 1 | |
Natural variantiVAR_002506 | 439 | R → P in NSHA; Pawnee; class I. 1 PublicationCorresponds to variant dbSNP:rs137852337Ensembl. | 1 | |
Natural variantiVAR_002507 | 440 | L → F in NSHA; Telti/Kobe; class I. Corresponds to variant dbSNP:rs1557229599EnsemblClinVar. | 1 | |
Natural variantiVAR_002508 | 447 | G → R in NSHA; Santiago de Cuba; class I. Corresponds to variant dbSNP:rs137852317Ensembl. | 1 | |
Natural variantiVAR_002509 | 449 | Q → H in NSHA; Cassano; class II. | 1 | |
Natural variantiVAR_002510 | 454 | R → C in NSHA; Chinese-II/Maewo/Union; class II; <1% activity. 1 PublicationCorresponds to variant dbSNP:rs398123546EnsemblClinVar. | 1 | |
Natural variantiVAR_002511 | 454 | R → H in NSHA; Andalus; class I. Corresponds to variant dbSNP:rs137852324Ensembl. | 1 | |
Natural variantiVAR_002512 | 459 | R → L in NSHA; Canton; class II; frequent in China. Corresponds to variant dbSNP:rs72554665Ensembl. | 1 | |
Natural variantiVAR_002513 | 459 | R → P in NSHA; Cosenza; class II. Corresponds to variant dbSNP:rs72554665Ensembl. | 1 | |
Natural variantiVAR_002515 | 488 | G → V in NSHA; Campinas; class I. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 171 | K → Q: Inhibits catalytic activity. Does not impair dimerization. 1 Publication | 1 | |
Mutagenesisi | 171 | K → R: Inhibits catalytic activity. Does not impair dimerization. 1 Publication | 1 | |
Mutagenesisi | 386 | K → Q: Impairs dimerization and reduces catalytic activity. 1 Publication | 1 | |
Mutagenesisi | 386 | K → R: Does not impair dimerization and catalytic activity. 1 Publication | 1 | |
Mutagenesisi | 403 | K → Q: Impairs dimerization and reduces catalytic activity in cells under oxidative stress. 1 Publication | 1 | |
Mutagenesisi | 403 | K → R: Does not impair dimerization and catalytic activity. 1 Publication | 1 |
Keywords - Diseasei
Disease variant, Hereditary hemolytic anemiaOrganism-specific databases
DisGeNETi | 2539 |
MalaCardsi | G6PD |
MIMi | 300908, phenotype |
OpenTargetsi | ENSG00000160211 |
Orphaneti | 466026, Class I glucose-6-phosphate dehydrogenase deficiency 362, NON RARE IN EUROPE: Glucose-6-phosphate-dehydrogenase deficiency |
PharmGKBi | PA28469 |
Miscellaneous databases
Pharosi | P11413, Tchem |
Chemistry databases
ChEMBLi | CHEMBL5347 |
DrugBanki | DB05107, 16-Bromoepiandrosterone DB11638, Artenimol DB03085, Glycolic acid DB03461, Nicotinamide adenine dinucleotide phosphate |
DrugCentrali | P11413 |
Genetic variation databases
BioMutai | G6PD |
DMDMi | 116242483 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources2 Publications | |||
ChainiPRO_0000068083 | 2 – 515 | Glucose-6-phosphate 1-dehydrogenaseAdd BLAST | 514 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources1 Publication | 1 | ||
Modified residuei | 8 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 10 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 89 | N6-acetyllysineCombined sources | 1 | ||
Modified residuei | 171 | N6-acetyllysineCombined sources | 1 | ||
Modified residuei | 403 | N6-acetyllysineCombined sources1 Publication | 1 | ||
Modified residuei | 432 | N6-acetyllysineCombined sources | 1 | ||
Modified residuei | 497 | N6-acetyllysineCombined sources | 1 | ||
Modified residuei | 503 | PhosphotyrosineCombined sources | 1 | ||
Isoform 3 (identifier: P11413-3) | |||||
Modified residuei | 26 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
CPTACi | CPTAC-204 CPTAC-205 |
EPDi | P11413 |
jPOSTi | P11413 |
MassIVEi | P11413 |
MaxQBi | P11413 |
PaxDbi | P11413 |
PeptideAtlasi | P11413 |
PRIDEi | P11413 |
ProteomicsDBi | 52771 [P11413-1] 52772 [P11413-2] 52773 [P11413-3] |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00289800 |
SWISS-2DPAGEi | P11413 |
PTM databases
iPTMneti | P11413 |
MetOSitei | P11413 |
PhosphoSitePlusi | P11413 |
SwissPalmi | P11413 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000160211, Expressed in blood and 186 other tissues |
ExpressionAtlasi | P11413, baseline and differential |
Genevisiblei | P11413, HS |
Organism-specific databases
HPAi | ENSG00000160211, Tissue enhanced (testis) |
Interactioni
Subunit structurei
Binary interactionsi
Hide detailsP11413
With | #Exp. | IntAct |
---|---|---|
itself | 3 | EBI-4289891,EBI-4289891 |
HSPB1 [P04792] | 2 | EBI-4289891,EBI-352682 |
SIRT2 [Q8IXJ6] | 3 | EBI-4289891,EBI-477232 |
GO - Molecular functioni
- identical protein binding Source: IntAct
- protein homodimerization activity Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 108814, 107 interactors |
IntActi | P11413, 23 interactors |
MINTi | P11413 |
STRINGi | 9606.ENSP00000377192 |
Chemistry databases
BindingDBi | P11413 |
Miscellaneous databases
RNActi | P11413, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P11413 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P11413 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 201 – 205 | Substrate bindingCombined sources1 Publication | 5 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0563, Eukaryota |
GeneTreei | ENSGT00530000063435 |
HOGENOMi | CLU_013524_2_3_1 |
InParanoidi | P11413 |
OMAi | VEICVYE |
OrthoDBi | 383995at2759 |
PhylomeDBi | P11413 |
TreeFami | TF300584 |
Family and domain databases
HAMAPi | MF_00966, G6PD, 1 hit |
InterProi | View protein in InterPro IPR001282, G6P_DH IPR019796, G6P_DH_AS IPR022675, G6P_DH_C IPR022674, G6P_DH_NAD-bd IPR036291, NAD(P)-bd_dom_sf |
PANTHERi | PTHR23429, PTHR23429, 1 hit |
Pfami | View protein in Pfam PF02781, G6PD_C, 1 hit PF00479, G6PD_N, 1 hit |
PIRSFi | PIRSF000110, G6PD, 1 hit |
PRINTSi | PR00079, G6PDHDRGNASE |
SUPFAMi | SSF51735, SSF51735, 1 hit |
TIGRFAMsi | TIGR00871, zwf, 1 hit |
PROSITEi | View protein in PROSITE PS00069, G6P_DEHYDROGENASE, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAEQVALSRT QVCGILREEL FQGDAFHQSD THIFIIMGAS GDLAKKKIYP
60 70 80 90 100
TIWWLFRDGL LPENTFIVGY ARSRLTVADI RKQSEPFFKA TPEEKLKLED
110 120 130 140 150
FFARNSYVAG QYDDAASYQR LNSHMNALHL GSQANRLFYL ALPPTVYEAV
160 170 180 190 200
TKNIHESCMS QIGWNRIIVE KPFGRDLQSS DRLSNHISSL FREDQIYRID
210 220 230 240 250
HYLGKEMVQN LMVLRFANRI FGPIWNRDNI ACVILTFKEP FGTEGRGGYF
260 270 280 290 300
DEFGIIRDVM QNHLLQMLCL VAMEKPASTN SDDVRDEKVK VLKCISEVQA
310 320 330 340 350
NNVVLGQYVG NPDGEGEATK GYLDDPTVPR GSTTATFAAV VLYVENERWD
360 370 380 390 400
GVPFILRCGK ALNERKAEVR LQFHDVAGDI FHQQCKRNEL VIRVQPNEAV
410 420 430 440 450
YTKMMTKKPG MFFNPEESEL DLTYGNRYKN VKLPDAYERL ILDVFCGSQM
460 470 480 490 500
HFVRSDELRE AWRIFTPLLH QIELEKPKPI PYIYGSRGPT EADELMKRVG
510
FQYEGTYKWV NPHKL
The sequence of this isoform differs from the canonical sequence as follows:
257-257: R → RGPGRQGGSGSESCSLSLGSLVWGPHALEPGEQGGELRRALASSVPR
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE7EUI8 | E7EUI8_HUMAN | Glucose-6-phosphate 1-dehydrogenase | G6PD | 338 | Annotation score: | ||
E7EM57 | E7EM57_HUMAN | Glucose-6-phosphate 1-dehydrogenase | G6PD | 320 | Annotation score: | ||
E9PD92 | E9PD92_HUMAN | Glucose-6-phosphate 1-dehydrogenase | G6PD | 256 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 11 | Q → H in CAA27309 (PubMed:3515319).Curated | 1 | |
Sequence conflicti | 11 | Q → H in AAA63175 (PubMed:2428611).Curated | 1 | |
Sequence conflicti | 11 | Q → H in AAA52500 (PubMed:2836867).Curated | 1 | |
Sequence conflicti | 435 – 436 | DA → EP in AAA52499 (PubMed:3012556).Curated | 2 |
Polymorphismi
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_002450 | 12 | V → L in Sinnai. 1 Publication | 1 | |
Natural variantiVAR_002451 | 32 | H → R in NSHA; Gahoe; class III; frequent in Chinese. 1 PublicationCorresponds to variant dbSNP:rs137852340Ensembl. | 1 | |
Natural variantiVAR_002452 | 35 | Missing in NSHA; Sunderland; class I. | 1 | |
Natural variantiVAR_002453 | 44 | A → G in NSHA; Orissa; class III; frequent in Indian tribal populations. 1 PublicationCorresponds to variant dbSNP:rs78478128Ensembl. | 1 | |
Natural variantiVAR_002454 | 48 | I → T in NSHA; Aures; class II. 1 PublicationCorresponds to variant dbSNP:rs76645461Ensembl. | 1 | |
Natural variantiVAR_002455 | 58 | D → N in NSHA; Metaponto; class III. Corresponds to variant dbSNP:rs137852315Ensembl. | 1 | |
Natural variantiVAR_002456 | 68 | V → M in NSHA; A(-) type I; class III; frequent in African population. 4 PublicationsCorresponds to variant dbSNP:rs1050828Ensembl. | 1 | |
Natural variantiVAR_002457 | 70 | Y → H in NSHA; Namoru; 4% activity. Corresponds to variant dbSNP:rs137852349Ensembl. | 1 | |
Natural variantiVAR_002458 | 75 | L → P in NSHA; Swansea; class I. 1 Publication | 1 | |
Natural variantiVAR_002460 | 81 | R → C in NSHA; Konan/Ube; class III. Corresponds to variant dbSNP:rs138687036Ensembl. | 1 | |
Natural variantiVAR_002459 | 81 | R → H in NSHA; Lagosanto; class III. Corresponds to variant dbSNP:rs782308266Ensembl. | 1 | |
Natural variantiVAR_002461 | 106 | S → C in NSHA; Vancouver; class I. Corresponds to variant dbSNP:rs267606835EnsemblClinVar. | 1 | |
Natural variantiVAR_002462 | 126 | N → D Found in Santa Maria and Mount Sinai; associated with C-387 in Mount Sinai; class IV and class I. 7 PublicationsCorresponds to variant dbSNP:rs1050829Ensembl. | 1 | |
Natural variantiVAR_002463 | 128 | L → P in NSHA; Vanua Lava; 4% activity. Corresponds to variant dbSNP:rs78365220EnsemblClinVar. | 1 | |
Natural variantiVAR_002464 | 131 | G → V in Chinese-4. Corresponds to variant dbSNP:rs137852341Ensembl. | 1 | |
Natural variantiVAR_002465 | 156 | E → K in NSHA; Ilesha; class III. Corresponds to variant dbSNP:rs137852313Ensembl. | 1 | |
Natural variantiVAR_002467 | 163 | G → D in NSHA; Plymouth; class I. 1 Publication | 1 | |
Natural variantiVAR_002466 | 163 | G → S in NSHA; Mahidol; class III; associated with reduced density of Plasmodium vivax but not Plasmodium falciparum in Southeast Asians; reduced activity. Corresponds to variant dbSNP:rs137852314Ensembl. | 1 | |
Natural variantiVAR_002468 | 165 | N → D in NSHA; Chinese-3; class II. Corresponds to variant dbSNP:rs137852331Ensembl. | 1 | |
Natural variantiVAR_002469 | 166 | R → H in NSHA; Naone; 1% activity. | 1 | |
Natural variantiVAR_002470 | 176 | D → G in NSHA; Shinshu; class I. 1 Publication | 1 | |
Natural variantiVAR_002471 | 181 | D → V in NSHA; Santa Maria; class I. Corresponds to variant dbSNP:rs5030872Ensembl. | 1 | |
Natural variantiVAR_002472 | 182 | R → W in NSHA; Vancouver; class I. Corresponds to variant dbSNP:rs267606836EnsemblClinVar. | 1 | |
Natural variantiVAR_081894 | 184 | S → F in Dindori; class II; 5% of activity. 1 PublicationCorresponds to variant dbSNP:rs782315572Ensembl. | 1 | |
Natural variantiVAR_002473 | 188 | S → F in NSHA; Sassari/Cagliari; class II; frequent in the Mediterranean. 1 PublicationCorresponds to variant dbSNP:rs5030868Ensembl. | 1 | |
Natural variantiVAR_002474 | 198 | R → C in Coimbra; class II. 1 PublicationCorresponds to variant dbSNP:rs137852330Ensembl. | 1 | |
Natural variantiVAR_081895 | 198 | R → H in Nilgiris; class II. 2 PublicationsCorresponds to variant dbSNP:rs137852332Ensembl. | 1 | |
Natural variantiVAR_002475 | 198 | R → P in NSHA; Santiago; class I. 1 PublicationCorresponds to variant dbSNP:rs137852332Ensembl. | 1 | |
Natural variantiVAR_075555 | 198 | R → S in NSHA; Herlev; loss of glucose-6-phosphate dehydrogenase activity. 1 Publication | 1 | |
Natural variantiVAR_002476 | 212 | M → V in NSHA; Sibari; class III. Corresponds to variant dbSNP:rs782754619Ensembl. | 1 | |
Natural variantiVAR_002477 | 213 | V → L in NSHA; Minnesota; class I. Corresponds to variant dbSNP:rs137852326Ensembl. | 1 | |
Natural variantiVAR_002478 | 216 | F → L in NSHA; Harilaou; class I. Corresponds to variant dbSNP:rs137852319Ensembl. | 1 | |
Natural variantiVAR_002480 | 227 | R → L in NSHA; A- type 2; class III. Corresponds to variant dbSNP:rs137852328EnsemblClinVar. | 1 | |
Natural variantiVAR_002479 | 227 | R → Q in Mexico City; class III. 1 PublicationCorresponds to variant dbSNP:rs137852328EnsemblClinVar. | 1 | |
Natural variantiVAR_002481 | 242 – 243 | Missing in NSHA; Stonybrook; class I. | 2 | |
Natural variantiVAR_002482 | 257 | R → G in NSHA; Wayne; class I. | 1 | |
Natural variantiVAR_002483 | 274 | E → K in NSHA; Corum; class I. 1 Publication | 1 | |
Natural variantiVAR_002484 | 278 | S → F in NSHA; Wexham; class I. 1 Publication | 1 | |
Natural variantiVAR_002485 | 279 | T → S in NSHA; Chinese-1; class II. | 1 | |
Natural variantiVAR_002486 | 282 | D → H in NSHA; Seattle; class III. 1 PublicationCorresponds to variant dbSNP:rs137852318Ensembl. | 1 | |
Natural variantiVAR_002487 | 285 | R → H in NSHA; Montalbano; class III. Corresponds to variant dbSNP:rs74575103Ensembl. | 1 | |
Natural variantiVAR_002488 | 291 | V → M in NSHA; Viangchan/Jammu; class II. Corresponds to variant dbSNP:rs137852327Ensembl. | 1 | |
Natural variantiVAR_002489 | 317 | E → K in NSHA; Kalyan/Kerala; class III. 1 PublicationCorresponds to variant dbSNP:rs137852339Ensembl. | 1 | |
Natural variantiVAR_081896 | 321 | G → V in NSHA; Bhavnagar; decreased enzyme stability. 1 Publication | 1 | |
Natural variantiVAR_020535 | 322 | Y → H in Rehovot. 1 PublicationCorresponds to variant dbSNP:rs137852347Ensembl. | 1 | |
Natural variantiVAR_002490 | 323 | L → P in NSHA; A- type 3; class III. Corresponds to variant dbSNP:rs76723693EnsemblClinVar. | 1 | |
Natural variantiVAR_002491 | 335 | A → T in NSHA; Chatham; class III. Corresponds to variant dbSNP:rs5030869Ensembl. | 1 | |
Natural variantiVAR_002492 | 342 | L → F in Chinese-5. Corresponds to variant dbSNP:rs137852342Ensembl. | 1 | |
Natural variantiVAR_002493 | 353 | P → S in Ierapetra; class II. 1 PublicationCorresponds to variant dbSNP:rs137852333Ensembl. | 1 | |
Natural variantiVAR_002494 | 363 | N → K in NSHA; Loma Linda; class I. Corresponds to variant dbSNP:rs137852329Ensembl. | 1 | |
Natural variantiVAR_002495 | 385 | C → R in NSHA; Tomah; class I. Corresponds to variant dbSNP:rs137852322Ensembl. | 1 | |
Natural variantiVAR_002496 | 386 | K → E in NSHA; Iowa; class I. Corresponds to variant dbSNP:rs137852320Ensembl. | 1 | |
Natural variantiVAR_002498 | 387 | R → C in NSHA; Guadajalara and Mount Sinai; class I. 2 PublicationsCorresponds to variant dbSNP:rs137852334Ensembl. | 1 | |
Natural variantiVAR_002497 | 387 | R → H in NSHA; Beverly Hills; class I. Corresponds to variant dbSNP:rs137852321Ensembl. | 1 | |
Natural variantiVAR_002499 | 393 | R → H in NSHA; Nashville/Anaheim; class I. 1 PublicationCorresponds to variant dbSNP:rs137852316Ensembl. | 1 | |
Natural variantiVAR_002500 | 394 | V → L in NSHA; Alhambra; class I. 1 PublicationCorresponds to variant dbSNP:rs137852335Ensembl. | 1 | |
Natural variantiVAR_002501 | 396 | P → L in NSHA; Bari; class I. 1 PublicationCorresponds to variant dbSNP:rs1557229683EnsemblClinVar. | 1 | |
Natural variantiVAR_002502 | 398 | E → K in NSHA; Puerto Limon; class I. Corresponds to variant dbSNP:rs137852325EnsemblClinVar. | 1 | |
Natural variantiVAR_002503 | 410 | G → C in NSHA; Riverside; class I. Corresponds to variant dbSNP:rs137852323Ensembl. | 1 | |
Natural variantiVAR_002504 | 410 | G → D in NSHA; Japan; class I. 1 PublicationCorresponds to variant dbSNP:rs137852336Ensembl. | 1 | |
Natural variantiVAR_002505 | 416 | E → K in NSHA; Tokyo; class I. | 1 | |
Natural variantiVAR_002506 | 439 | R → P in NSHA; Pawnee; class I. 1 PublicationCorresponds to variant dbSNP:rs137852337Ensembl. | 1 | |
Natural variantiVAR_002507 | 440 | L → F in NSHA; Telti/Kobe; class I. Corresponds to variant dbSNP:rs1557229599EnsemblClinVar. | 1 | |
Natural variantiVAR_002508 | 447 | G → R in NSHA; Santiago de Cuba; class I. Corresponds to variant dbSNP:rs137852317Ensembl. | 1 | |
Natural variantiVAR_002509 | 449 | Q → H in NSHA; Cassano; class II. | 1 | |
Natural variantiVAR_002510 | 454 | R → C in NSHA; Chinese-II/Maewo/Union; class II; <1% activity. 1 PublicationCorresponds to variant dbSNP:rs398123546EnsemblClinVar. | 1 | |
Natural variantiVAR_002511 | 454 | R → H in NSHA; Andalus; class I. Corresponds to variant dbSNP:rs137852324Ensembl. | 1 | |
Natural variantiVAR_002512 | 459 | R → L in NSHA; Canton; class II; frequent in China. Corresponds to variant dbSNP:rs72554665Ensembl. | 1 | |
Natural variantiVAR_002513 | 459 | R → P in NSHA; Cosenza; class II. Corresponds to variant dbSNP:rs72554665Ensembl. | 1 | |
Natural variantiVAR_002514 | 463 | R → H in Kaiping; class II. 1 PublicationCorresponds to variant dbSNP:rs72554664Ensembl. | 1 | |
Natural variantiVAR_002515 | 488 | G → V in NSHA; Campinas; class I. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_037802 | 1 | M → MGRRGSAPGNGRTLRGCERG GRRRRSADSVM in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_001592 | 257 | R → RGPGRQGGSGSESCSLSLGS LVWGPHALEPGEQGGELRRA LASSVPR in isoform Long. Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X03674 mRNA Translation: CAA27309.1 M65234 , M26749, M26750, M65225, M65226, M65227, M65228, M65229, M65230, M65231, M65233, M65232 Genomic DNA Translation: AAA63175.1 Different initiation. M21248 mRNA Translation: AAA52500.1 M19866 mRNA Translation: AAA52501.1 X55448 Genomic DNA Translation: CAA39089.1 L44140 Genomic DNA Translation: AAA92653.1 AF277315 Genomic DNA Translation: AAL27011.1 CH471172 Genomic DNA Translation: EAW72682.1 CH471172 Genomic DNA Translation: EAW72686.1 BC000337 mRNA Translation: AAH00337.1 M27940 mRNA Translation: AAA52504.1 S58359 mRNA Translation: AAB26169.1 X53815 Genomic DNA Translation: CAA37811.1 S64462 Genomic DNA Translation: AAB20299.1 AY158096 Genomic DNA Translation: AAN76367.1 AY158097 Genomic DNA Translation: AAN76368.1 AY158098 Genomic DNA Translation: AAN76369.1 AY158099 Genomic DNA Translation: AAN76370.1 AY158100 Genomic DNA Translation: AAN76371.1 AY158101 Genomic DNA Translation: AAN76372.1 AY158102 Genomic DNA Translation: AAN76373.1 AY158103 Genomic DNA Translation: AAN76374.1 AY158104 Genomic DNA Translation: AAN76375.1 AY158105 Genomic DNA Translation: AAN76376.1 AY158106 Genomic DNA Translation: AAN76377.1 AY158107 Genomic DNA Translation: AAN76378.1 AY158108 Genomic DNA Translation: AAN76379.1 AY158109 Genomic DNA Translation: AAN76380.1 AY158110 Genomic DNA Translation: AAN76381.1 AY158111 Genomic DNA Translation: AAN76382.1 AY158112 Genomic DNA Translation: AAN76383.1 AY158113 Genomic DNA Translation: AAN76384.1 AY158114 Genomic DNA Translation: AAN76385.1 AY158115 Genomic DNA Translation: AAN76386.1 AY158116 Genomic DNA Translation: AAN76387.1 AY158117 Genomic DNA Translation: AAN76388.1 AY158118 Genomic DNA Translation: AAN76389.1 AY158119 Genomic DNA Translation: AAN76390.1 AY158120 Genomic DNA Translation: AAN76391.1 AY158121 Genomic DNA Translation: AAN76392.1 AY158122 Genomic DNA Translation: AAN76393.1 AY158123 Genomic DNA Translation: AAN76394.1 AY158124 Genomic DNA Translation: AAN76395.1 AY158125 Genomic DNA Translation: AAN76396.1 AY158126 Genomic DNA Translation: AAN76397.1 AY158127 Genomic DNA Translation: AAN76398.1 AY158128 Genomic DNA Translation: AAN76399.1 AY158129 Genomic DNA Translation: AAN76400.1 AY158130 Genomic DNA Translation: AAN76401.1 AY158131 Genomic DNA Translation: AAN76402.1 AY158132 Genomic DNA Translation: AAN76403.1 AY158133 Genomic DNA Translation: AAN76404.1 AY158134 Genomic DNA Translation: AAN76405.1 AY158135 Genomic DNA Translation: AAN76406.1 AY158136 Genomic DNA Translation: AAN76407.1 AY158137 Genomic DNA Translation: AAN76408.1 AY158138 Genomic DNA Translation: AAN76409.1 AY158139 Genomic DNA Translation: AAN76410.1 AY158140 Genomic DNA Translation: AAN76411.1 AY158141 Genomic DNA Translation: AAN76412.1 AY158142 Genomic DNA Translation: AAN76413.1 M12996 mRNA Translation: AAA52499.1 M23423 Genomic DNA Translation: AAB59390.1 |
CCDSi | CCDS44023.1 [P11413-1] |
PIRi | A40309, DEHUG6 |
RefSeqi | NP_000393.4, NM_000402.4 [P11413-3] NP_001035810.1, NM_001042351.2 [P11413-1] |
Genome annotation databases
Ensembli | ENST00000369620; ENSP00000358633; ENSG00000160211 [P11413-2] ENST00000393562; ENSP00000377192; ENSG00000160211 [P11413-1] ENST00000393564; ENSP00000377194; ENSG00000160211 [P11413-1] |
GeneIDi | 2539 |
KEGGi | hsa:2539 |
UCSCi | uc004flx.3, human [P11413-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
G6PDdb G6PD mutation database |
SHMPD The Singapore human mutation and polymorphism database |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X03674 mRNA Translation: CAA27309.1 M65234 , M26749, M26750, M65225, M65226, M65227, M65228, M65229, M65230, M65231, M65233, M65232 Genomic DNA Translation: AAA63175.1 Different initiation. M21248 mRNA Translation: AAA52500.1 M19866 mRNA Translation: AAA52501.1 X55448 Genomic DNA Translation: CAA39089.1 L44140 Genomic DNA Translation: AAA92653.1 AF277315 Genomic DNA Translation: AAL27011.1 CH471172 Genomic DNA Translation: EAW72682.1 CH471172 Genomic DNA Translation: EAW72686.1 BC000337 mRNA Translation: AAH00337.1 M27940 mRNA Translation: AAA52504.1 S58359 mRNA Translation: AAB26169.1 X53815 Genomic DNA Translation: CAA37811.1 S64462 Genomic DNA Translation: AAB20299.1 AY158096 Genomic DNA Translation: AAN76367.1 AY158097 Genomic DNA Translation: AAN76368.1 AY158098 Genomic DNA Translation: AAN76369.1 AY158099 Genomic DNA Translation: AAN76370.1 AY158100 Genomic DNA Translation: AAN76371.1 AY158101 Genomic DNA Translation: AAN76372.1 AY158102 Genomic DNA Translation: AAN76373.1 AY158103 Genomic DNA Translation: AAN76374.1 AY158104 Genomic DNA Translation: AAN76375.1 AY158105 Genomic DNA Translation: AAN76376.1 AY158106 Genomic DNA Translation: AAN76377.1 AY158107 Genomic DNA Translation: AAN76378.1 AY158108 Genomic DNA Translation: AAN76379.1 AY158109 Genomic DNA Translation: AAN76380.1 AY158110 Genomic DNA Translation: AAN76381.1 AY158111 Genomic DNA Translation: AAN76382.1 AY158112 Genomic DNA Translation: AAN76383.1 AY158113 Genomic DNA Translation: AAN76384.1 AY158114 Genomic DNA Translation: AAN76385.1 AY158115 Genomic DNA Translation: AAN76386.1 AY158116 Genomic DNA Translation: AAN76387.1 AY158117 Genomic DNA Translation: AAN76388.1 AY158118 Genomic DNA Translation: AAN76389.1 AY158119 Genomic DNA Translation: AAN76390.1 AY158120 Genomic DNA Translation: AAN76391.1 AY158121 Genomic DNA Translation: AAN76392.1 AY158122 Genomic DNA Translation: AAN76393.1 AY158123 Genomic DNA Translation: AAN76394.1 AY158124 Genomic DNA Translation: AAN76395.1 AY158125 Genomic DNA Translation: AAN76396.1 AY158126 Genomic DNA Translation: AAN76397.1 AY158127 Genomic DNA Translation: AAN76398.1 AY158128 Genomic DNA Translation: AAN76399.1 AY158129 Genomic DNA Translation: AAN76400.1 AY158130 Genomic DNA Translation: AAN76401.1 AY158131 Genomic DNA Translation: AAN76402.1 AY158132 Genomic DNA Translation: AAN76403.1 AY158133 Genomic DNA Translation: AAN76404.1 AY158134 Genomic DNA Translation: AAN76405.1 AY158135 Genomic DNA Translation: AAN76406.1 AY158136 Genomic DNA Translation: AAN76407.1 AY158137 Genomic DNA Translation: AAN76408.1 AY158138 Genomic DNA Translation: AAN76409.1 AY158139 Genomic DNA Translation: AAN76410.1 AY158140 Genomic DNA Translation: AAN76411.1 AY158141 Genomic DNA Translation: AAN76412.1 AY158142 Genomic DNA Translation: AAN76413.1 M12996 mRNA Translation: AAA52499.1 M23423 Genomic DNA Translation: AAB59390.1 |
CCDSi | CCDS44023.1 [P11413-1] |
PIRi | A40309, DEHUG6 |
RefSeqi | NP_000393.4, NM_000402.4 [P11413-3] NP_001035810.1, NM_001042351.2 [P11413-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1QKI | X-ray | 3.00 | A/B/C/D/E/F/G/H | 2-515 | [»] | |
2BH9 | X-ray | 2.50 | A | 27-515 | [»] | |
2BHL | X-ray | 2.90 | A/B | 28-515 | [»] | |
5UKW | X-ray | 2.65 | A | 29-511 | [»] | |
6E07 | X-ray | 2.60 | B/C/F/L/N/Q/T/W | 1-515 | [»] | |
6E08 | X-ray | 1.90 | L | 1-515 | [»] | |
6JYU | X-ray | 1.89 | A | 29-513 | [»] | |
SMRi | P11413 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108814, 107 interactors |
IntActi | P11413, 23 interactors |
MINTi | P11413 |
STRINGi | 9606.ENSP00000377192 |
Chemistry databases
BindingDBi | P11413 |
ChEMBLi | CHEMBL5347 |
DrugBanki | DB05107, 16-Bromoepiandrosterone DB11638, Artenimol DB03085, Glycolic acid DB03461, Nicotinamide adenine dinucleotide phosphate |
DrugCentrali | P11413 |
PTM databases
iPTMneti | P11413 |
MetOSitei | P11413 |
PhosphoSitePlusi | P11413 |
SwissPalmi | P11413 |
Genetic variation databases
BioMutai | G6PD |
DMDMi | 116242483 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00289800 |
SWISS-2DPAGEi | P11413 |
Proteomic databases
CPTACi | CPTAC-204 CPTAC-205 |
EPDi | P11413 |
jPOSTi | P11413 |
MassIVEi | P11413 |
MaxQBi | P11413 |
PaxDbi | P11413 |
PeptideAtlasi | P11413 |
PRIDEi | P11413 |
ProteomicsDBi | 52771 [P11413-1] 52772 [P11413-2] 52773 [P11413-3] |
Protocols and materials databases
Antibodypediai | 352, 731 antibodies |
DNASUi | 2539 |
Genome annotation databases
Ensembli | ENST00000369620; ENSP00000358633; ENSG00000160211 [P11413-2] ENST00000393562; ENSP00000377192; ENSG00000160211 [P11413-1] ENST00000393564; ENSP00000377194; ENSG00000160211 [P11413-1] |
GeneIDi | 2539 |
KEGGi | hsa:2539 |
UCSCi | uc004flx.3, human [P11413-1] |
Organism-specific databases
CTDi | 2539 |
DisGeNETi | 2539 |
GeneCardsi | G6PD |
HGNCi | HGNC:4057, G6PD |
HPAi | ENSG00000160211, Tissue enhanced (testis) |
MalaCardsi | G6PD |
MIMi | 300908, phenotype 305900, gene |
neXtProti | NX_P11413 |
OpenTargetsi | ENSG00000160211 |
Orphaneti | 466026, Class I glucose-6-phosphate dehydrogenase deficiency 362, NON RARE IN EUROPE: Glucose-6-phosphate-dehydrogenase deficiency |
PharmGKBi | PA28469 |
VEuPathDBi | HostDB:ENSG00000160211.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0563, Eukaryota |
GeneTreei | ENSGT00530000063435 |
HOGENOMi | CLU_013524_2_3_1 |
InParanoidi | P11413 |
OMAi | VEICVYE |
OrthoDBi | 383995at2759 |
PhylomeDBi | P11413 |
TreeFami | TF300584 |
Enzyme and pathway databases
UniPathwayi | UPA00115;UER00408 |
BioCyci | MetaCyc:HS08467-MONOMER |
BRENDAi | 1.1.1.49, 2681 |
PathwayCommonsi | P11413 |
Reactomei | R-HSA-5628897, TP53 Regulates Metabolic Genes R-HSA-71336, Pentose phosphate pathway |
SABIO-RKi | P11413 |
SIGNORi | P11413 |
Miscellaneous databases
BioGRID-ORCSi | 2539, 55 hits in 633 CRISPR screens |
ChiTaRSi | G6PD, human |
EvolutionaryTracei | P11413 |
GeneWikii | Glucose-6-phosphate_dehydrogenase |
GenomeRNAii | 2539 |
Pharosi | P11413, Tchem |
PROi | PR:P11413 |
RNActi | P11413, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000160211, Expressed in blood and 186 other tissues |
ExpressionAtlasi | P11413, baseline and differential |
Genevisiblei | P11413, HS |
Family and domain databases
HAMAPi | MF_00966, G6PD, 1 hit |
InterProi | View protein in InterPro IPR001282, G6P_DH IPR019796, G6P_DH_AS IPR022675, G6P_DH_C IPR022674, G6P_DH_NAD-bd IPR036291, NAD(P)-bd_dom_sf |
PANTHERi | PTHR23429, PTHR23429, 1 hit |
Pfami | View protein in Pfam PF02781, G6PD_C, 1 hit PF00479, G6PD_N, 1 hit |
PIRSFi | PIRSF000110, G6PD, 1 hit |
PRINTSi | PR00079, G6PDHDRGNASE |
SUPFAMi | SSF51735, SSF51735, 1 hit |
TIGRFAMsi | TIGR00871, zwf, 1 hit |
PROSITEi | View protein in PROSITE PS00069, G6P_DEHYDROGENASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G6PD_HUMAN | |
Accessioni | P11413Primary (citable) accession number: P11413 Secondary accession number(s): D3DWX9 Q96PQ2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1989 |
Last sequence update: | January 23, 2007 | |
Last modified: | April 7, 2021 | |
This is version 256 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families