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Protein

Fatty acid-binding protein, heart

Gene

Fabp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei127Fatty acidBy similarity1
Binding sitei129Fatty acidBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-MMU-163560 Triglyceride catabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid-binding protein, heart
Alternative name(s):
Fatty acid-binding protein 3
Heart-type fatty acid-binding protein
Short name:
H-FABP
Mammary-derived growth inhibitor
Short name:
MDGI
Gene namesi
Name:Fabp3
Synonyms:Fabph1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:95476 Fabp3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000673222 – 133Fatty acid-binding protein, heartAdd BLAST132

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei8PhosphothreonineBy similarity1
Modified residuei20Phosphotyrosine; by Tyr-kinasesBy similarity1
Modified residuei23PhosphoserineBy similarity1
Modified residuei30PhosphothreonineBy similarity1
Modified residuei83PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP11404
PeptideAtlasiP11404
PRIDEiP11404

2D gel databases

REPRODUCTION-2DPAGEiIPI00230124
P11404
SWISS-2DPAGEiP11404
UCD-2DPAGEiP11404

PTM databases

iPTMnetiP11404
PhosphoSitePlusiP11404

Expressioni

Gene expression databases

BgeeiENSMUSG00000028773 Expressed in 76 organ(s), highest expression level in heart
CleanExiMM_FABP3
ExpressionAtlasiP11404 baseline and differential
GenevisibleiP11404 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199582, 1 interactor
IntActiP11404, 7 interactors
MINTiP11404
STRINGi10090.ENSMUSP00000070709

Structurei

3D structure databases

ProteinModelPortaliP11404
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015 Eukaryota
ENOG4111US8 LUCA
GeneTreeiENSGT00760000118898
HOGENOMiHOG000004829
HOVERGENiHBG005633
InParanoidiP11404
KOiK08752
OMAiTIIIKTH
OrthoDBiEOG091G0QSV
PhylomeDBiP11404
TreeFamiTF316894

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR000463 Fatty_acid-bd
IPR031259 ILBP
IPR000566 Lipocln_cytosolic_FA-bd_dom
PANTHERiPTHR11955 PTHR11955, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PRINTSiPR00178 FATTYACIDBP
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00214 FABP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11404-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADAFVGTWK LVDSKNFDDY MKSLGVGFAT RQVASMTKPT TIIEKNGDTI
60 70 80 90 100
TIKTQSTFKN TEINFQLGIE FDEVTADDRK VKSLVTLDGG KLIHVQKWNG
110 120 130
QETTLTRELV DGKLILTLTH GSVVSTRTYE KEA
Length:133
Mass (Da):14,819
Last modified:January 23, 2007 - v5
Checksum:iF78BFF5A7533DD9A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34A → G in CAA33084 (PubMed:2740224).Curated1
Sequence conflicti99N → D in CAA33084 (PubMed:2740224).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14961 mRNA Translation: CAA33084.1
U02884 Genomic DNA Translation: AAA61933.1
U02883 mRNA Translation: AAA03445.1
BC002082 mRNA Translation: AAH02082.1
CCDSiCCDS18709.1
PIRiPC4011
RefSeqiNP_034304.1, NM_010174.1
UniGeneiMm.388886

Genome annotation databases

EnsembliENSMUST00000070532; ENSMUSP00000070709; ENSMUSG00000028773
GeneIDi14077
KEGGimmu:14077
UCSCiuc008uzd.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14961 mRNA Translation: CAA33084.1
U02884 Genomic DNA Translation: AAA61933.1
U02883 mRNA Translation: AAA03445.1
BC002082 mRNA Translation: AAH02082.1
CCDSiCCDS18709.1
PIRiPC4011
RefSeqiNP_034304.1, NM_010174.1
UniGeneiMm.388886

3D structure databases

ProteinModelPortaliP11404
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199582, 1 interactor
IntActiP11404, 7 interactors
MINTiP11404
STRINGi10090.ENSMUSP00000070709

PTM databases

iPTMnetiP11404
PhosphoSitePlusiP11404

2D gel databases

REPRODUCTION-2DPAGEiIPI00230124
P11404
SWISS-2DPAGEiP11404
UCD-2DPAGEiP11404

Proteomic databases

PaxDbiP11404
PeptideAtlasiP11404
PRIDEiP11404

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000070532; ENSMUSP00000070709; ENSMUSG00000028773
GeneIDi14077
KEGGimmu:14077
UCSCiuc008uzd.1 mouse

Organism-specific databases

CTDi2170
MGIiMGI:95476 Fabp3

Phylogenomic databases

eggNOGiKOG4015 Eukaryota
ENOG4111US8 LUCA
GeneTreeiENSGT00760000118898
HOGENOMiHOG000004829
HOVERGENiHBG005633
InParanoidiP11404
KOiK08752
OMAiTIIIKTH
OrthoDBiEOG091G0QSV
PhylomeDBiP11404
TreeFamiTF316894

Enzyme and pathway databases

ReactomeiR-MMU-163560 Triglyceride catabolism

Miscellaneous databases

PROiPR:P11404
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028773 Expressed in 76 organ(s), highest expression level in heart
CleanExiMM_FABP3
ExpressionAtlasiP11404 baseline and differential
GenevisibleiP11404 MM

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR000463 Fatty_acid-bd
IPR031259 ILBP
IPR000566 Lipocln_cytosolic_FA-bd_dom
PANTHERiPTHR11955 PTHR11955, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PRINTSiPR00178 FATTYACIDBP
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00214 FABP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFABPH_MOUSE
AccessioniPrimary (citable) accession number: P11404
Secondary accession number(s): Q91W23
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 167 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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