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Protein

Fibroblast growth factor 4

Gene

Fgf4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Is essential for survival of the postimplantation mouse embryo. Required for normal limb and cardiac valve development during embryogenesis.

GO - Molecular functioni

GO - Biological processi

  • apoptotic process involved in morphogenesis Source: MGI
  • cartilage condensation Source: MGI
  • cellular response to leukemia inhibitory factor Source: MGI
  • chondroblast differentiation Source: MGI
  • cranial suture morphogenesis Source: MGI
  • embryonic hindlimb morphogenesis Source: MGI
  • embryonic limb morphogenesis Source: MGI
  • fibroblast growth factor receptor signaling pathway Source: MGI
  • mesenchymal cell proliferation Source: MGI
  • negative regulation of apoptotic process Source: MGI
  • odontogenesis of dentin-containing tooth Source: MGI
  • positive regulation of cell division Source: UniProtKB-KW
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of ERK1 and ERK2 cascade Source: MGI
  • positive regulation of gene expression Source: MGI
  • positive regulation of protein phosphorylation Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • regulation of endothelial cell chemotaxis to fibroblast growth factor Source: MGI
  • regulation of gene expression Source: MGI
  • stem cell population maintenance Source: MGI

Keywordsi

Molecular functionDevelopmental protein, Growth factor, Mitogen
Biological processDifferentiation

Enzyme and pathway databases

ReactomeiR-MMU-109704 PI3K Cascade
R-MMU-1257604 PIP3 activates AKT signaling
R-MMU-190322 FGFR4 ligand binding and activation
R-MMU-190372 FGFR3c ligand binding and activation
R-MMU-190373 FGFR1c ligand binding and activation
R-MMU-190375 FGFR2c ligand binding and activation
R-MMU-5654219 Phospholipase C-mediated cascade: FGFR1
R-MMU-5654221 Phospholipase C-mediated cascade, FGFR2
R-MMU-5654227 Phospholipase C-mediated cascade, FGFR3
R-MMU-5654228 Phospholipase C-mediated cascade, FGFR4
R-MMU-5654687 Downstream signaling of activated FGFR1
R-MMU-5654688 SHC-mediated cascade:FGFR1
R-MMU-5654689 PI-3K cascade:FGFR1
R-MMU-5654693 FRS-mediated FGFR1 signaling
R-MMU-5654695 PI-3K cascade:FGFR2
R-MMU-5654699 SHC-mediated cascade:FGFR2
R-MMU-5654700 FRS-mediated FGFR2 signaling
R-MMU-5654704 SHC-mediated cascade:FGFR3
R-MMU-5654706 FRS-mediated FGFR3 signaling
R-MMU-5654710 PI-3K cascade:FGFR3
R-MMU-5654712 FRS-mediated FGFR4 signaling
R-MMU-5654719 SHC-mediated cascade:FGFR4
R-MMU-5654720 PI-3K cascade:FGFR4
R-MMU-5654726 Negative regulation of FGFR1 signaling
R-MMU-5654727 Negative regulation of FGFR2 signaling
R-MMU-5654732 Negative regulation of FGFR3 signaling
R-MMU-5654733 Negative regulation of FGFR4 signaling
R-MMU-5658623 FGFRL1 modulation of FGFR1 signaling
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 4
Short name:
FGF-4
Alternative name(s):
Heparin-binding growth factor 4
Short name:
HBGF-4
K-fibroblast growth factor
Gene namesi
Name:Fgf4
Synonyms:Fgf-4, Kfgf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:95518 Fgf4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000000895430 – 202Fibroblast growth factor 4Add BLAST173

Proteomic databases

PaxDbiP11403
PeptideAtlasiP11403
PRIDEiP11403

PTM databases

iPTMnetiP11403
PhosphoSitePlusiP11403

Expressioni

Tissue specificityi

Expressed in the blastocyst inner cell mass and later in distinct embryonic tissues.

Gene expression databases

BgeeiENSMUSG00000050917
CleanExiMM_FGF4
ExpressionAtlasiP11403 baseline and differential
GenevisibleiP11403 MM

Interactioni

Subunit structurei

Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056752

Structurei

3D structure databases

ProteinModelPortaliP11403
SMRiP11403
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3885 Eukaryota
ENOG4111IPH LUCA
GeneTreeiENSGT00760000118859
HOGENOMiHOG000236341
HOVERGENiHBG007580
InParanoidiP11403
KOiK04358
OMAiYNAYESH
OrthoDBiEOG091G0NAY
TreeFamiTF317805

Family and domain databases

CDDicd00058 FGF, 1 hit
InterProiView protein in InterPro
IPR028239 FGF4
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF
PANTHERiPTHR11486 PTHR11486, 1 hit
PTHR11486:SF31 PTHR11486:SF31, 1 hit
PfamiView protein in Pfam
PF00167 FGF, 1 hit
PRINTSiPR00263 HBGFFGF
SMARTiView protein in SMART
SM00442 FGF, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00247 HBGF_FGF, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11403-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKRGPTTGT LLPRVLLALV VALADRGTAA PNGTRHAELG HGWDGLVARS
60 70 80 90 100
LARLPVAAQP PQAAVRSGAG DYLLGLKRLR RLYCNVGIGF HLQVLPDGRI
110 120 130 140 150
GGVHADTRDS LLELSPVQRG VVSIFGVASR FFVAMSSRGK LFGVPFFTDE
160 170 180 190 200
CKFKEILLPN NYNAYESYAY PGMFMALSKN GRTKKGNRVS PTMKVTHFLP

RL
Length:202
Mass (Da):21,919
Last modified:October 3, 2012 - v2
Checksum:i62D4563AF7D9AA31
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti167S → A in CAA32967 (PubMed:2740210).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14849 Genomic DNA Translation: CAA32967.1
M30642 mRNA Translation: AAA37619.1
AK082814 mRNA Translation: BAC38631.1
AC149593 Genomic DNA No translation available.
AC161763 Genomic DNA No translation available.
CH466531 Genomic DNA Translation: EDL18271.1
BC104312 mRNA Translation: AAI04313.1
BC104313 mRNA Translation: AAI04314.1
CCDSiCCDS22052.1
PIRiS04741 TVMSHS
RefSeqiNP_034332.2, NM_010202.6
UniGeneiMm.4956

Genome annotation databases

EnsembliENSMUST00000060336; ENSMUSP00000056752; ENSMUSG00000050917
GeneIDi14175
KEGGimmu:14175
UCSCiuc009kqq.1 mouse

Similar proteinsi

Entry informationi

Entry nameiFGF4_MOUSE
AccessioniPrimary (citable) accession number: P11403
Secondary accession number(s): P15657, Q542N0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: October 3, 2012
Last modified: March 28, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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