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Protein

Secretin

Gene

Sct

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Stimulates formation of NaHCO3-rich pancreatic juice and secretion of NaHCO3-rich bile and inhibits HCl production by the stomach.

GO - Molecular functioni

  • G-protein coupled receptor binding Source: Ensembl
  • hormone activity Source: UniProtKB-KW
  • protein N-terminus binding Source: RGD
  • signaling receptor binding Source: RGD

GO - Biological processi

  • brain development Source: RGD
  • embryonic digestive tract development Source: RGD
  • negative regulation of gastrin-induced gastric acid secretion Source: RGD
  • positive regulation of cAMP-mediated signaling Source: RGD
  • positive regulation of pancreatic juice secretion Source: RGD
  • positive regulation of somatostatin secretion Source: RGD

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-RNO-418555 G alpha (s) signalling events
R-RNO-420092 Glucagon-type ligand receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Secretin
Gene namesi
Name:Sct
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi3643 Sct

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000001143222 – 3110
PeptideiPRO_000001143333 – 59SecretinAdd BLAST27
PropeptideiPRO_000001143463 – 134Add BLAST72

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei59Valine amide1 Publication1
Modified residuei63PhosphoserineCombined sources1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Phosphoprotein

Proteomic databases

PaxDbiP11384

PTM databases

iPTMnetiP11384
PhosphoSitePlusiP11384

Expressioni

Gene expression databases

BgeeiENSRNOG00000017873
GenevisibleiP11384 RN

Interactioni

GO - Molecular functioni

  • G-protein coupled receptor binding Source: Ensembl
  • hormone activity Source: UniProtKB-KW
  • protein N-terminus binding Source: RGD
  • signaling receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024094

Structurei

3D structure databases

SMRiP11384
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucagon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JG0Y Eukaryota
ENOG4111AMM LUCA
GeneTreeiENSGT00390000002624
HOGENOMiHOG000133017
HOVERGENiHBG017786
InParanoidiP11384
KOiK05263
OMAiMPILQAW
OrthoDBiEOG091G12NH
PhylomeDBiP11384
TreeFamiTF338215

Family and domain databases

InterProiView protein in InterPro
IPR000532 Glucagon_GIP_secretin_VIP
IPR015675 Prosecretin
PANTHERiPTHR17378 PTHR17378, 1 hit
PfamiView protein in Pfam
PF00123 Hormone_2, 1 hit
SMARTiView protein in SMART
SM00070 GLUCA, 1 hit
PROSITEiView protein in PROSITE
PS00260 GLUCAGON, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11384-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPLLPTPPL LLLLLLLLSS SFVLPAPPRT PRHSDGTFTS ELSRLQDSAR
60 70 80 90 100
LQRLLQGLVG KRSEEDTENI PENSVARPKP LEDQLCLLWS NTQALQDWLL
110 120 130
PRLSLDGSLS LWLPPGPRPA VDHSEWTETT RQPR
Length:134
Mass (Da):15,072
Last modified:April 1, 1990 - v2
Checksum:iD9FA1A4C1F7C86E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31495 mRNA Translation: AAA42126.1
M64033 Genomic DNA Translation: AAA42128.1
M63984 Genomic DNA Translation: AAA42127.1
PIRiA40886 A40959
RefSeqiNP_073161.1, NM_022670.2
XP_006230580.1, XM_006230518.3
UniGeneiRn.9919

Genome annotation databases

EnsembliENSRNOT00000024094; ENSRNOP00000024094; ENSRNOG00000017873
GeneIDi24769
KEGGirno:24769
UCSCiRGD:3643 rat

Similar proteinsi

Entry informationi

Entry nameiSECR_RAT
AccessioniPrimary (citable) accession number: P11384
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: April 1, 1990
Last modified: June 20, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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