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Entry version 108 (16 Oct 2019)
Sequence version 2 (01 Feb 2005)
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Protein

LINE-1 retrotransposable element ORF2 protein

Gene

Pol

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has a reverse transcriptase activity required for target-primed reverse transcription of the LINE-1 element mRNA, a crucial step in LINE-1 retrotransposition. Has also an endonuclease activity that allows the introduction of nicks in the chromosomal target DNA. Cleaves DNA in AT-rich regions between a 5' stretch of purines and a 3' stretch of pyrimidines, corresponding to sites of LINE-1 integration in the genome.

Miscellaneous

An active LINE-1 encodes for 2 proteins translated from a single RNA containing two non-overlapping ORFs, ORF1 and ORF2. ORF2p is described in that entry as a representative of all ORF2p potentially expressed by active elements in mouse genome. ORF1p is described in the related entry AC P11260.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi607Magnesium; catalyticPROSITE-ProRule annotation1
Metal bindingi709Magnesium; catalyticPROSITE-ProRule annotation1
Metal bindingi710Magnesium; catalyticPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEndonuclease, Hydrolase, Multifunctional enzyme, Nuclease, Nucleotidyltransferase, RNA-directed DNA polymerase, Transferase
Biological processDNA recombination
LigandMagnesium, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
LINE-1 retrotransposable element ORF2 protein
Short name:
ORF2p
Alternative name(s):
Long interspersed element-1
Short name:
L1
Retrovirus-related Pol polyprotein LINE-1
Including the following 2 domains:
Reverse transcriptase (EC:2.7.7.49)
Endonuclease (EC:3.1.21.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pol
Synonyms:Gm17492
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000585091 – 1281LINE-1 retrotransposable element ORF2 proteinAdd BLAST1281

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P11369

PRoteomics IDEntifications database

More...
PRIDEi
P11369

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P11369

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P11369

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MOV10.

1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000137421

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P11369

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini505 – 780Reverse transcriptasePROSITE-ProRule annotationAdd BLAST276
Domaini1247 – 1266DUF1725Add BLAST20

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 245Endonuclease activityBy similarityAdd BLAST245

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J1P7 Eukaryota
ENOG41120A8 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P11369

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.60.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013544 DUF1725
IPR036691 Endo/exonu/phosph_ase_sf
IPR005135 Endo/exonuclease/phosphatase
IPR000477 RT_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08333 DUF1725, 1 hit
PF03372 Exo_endo_phos, 1 hit
PF00078 RVT_1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56219 SSF56219, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50878 RT_POL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P11369-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPTLTTKIKG SNNYFSLISL NINGLNSPIK RHRLTDWLHK QDPTFCCLQE
60 70 80 90 100
THLREKDRHY LRVKGWKTIF QANGLKKQAG VAILISDKID FQPKVIKKDK
110 120 130 140 150
EGHFILIKGK ILQEELSILN IYAPNARAAT FIRDTLVKLK AYIAPHTIIV
160 170 180 190 200
GDFNTPLSSK DRSWKQKLNR DTVKLTEVMK QMDLTDIYRT FYPKTKGYTF
210 220 230 240 250
FSAPHGTFSK IDHIIGHKTG LNRYKNIEIV PCILSDHHGL RLIFNNNINN
260 270 280 290 300
GKPTFTWKLN NTLLNDTLVK EGIKKEIKDF LEFNENEATT YPNLWDTMKA
310 320 330 340 350
FLRGKLIALS ASKKKRETAH TSSLTTHLKA LEKKEANSPK RSRRQEIIKL
360 370 380 390 400
RGEINQVETR RTIQRINQTR SWFFEKINKI DKPLARLTKG HRDKILINKI
410 420 430 440 450
RNEKGDITTD PEEIQNTIRS FYKRLYSTKL ENLDEMDKFL DRYQVPKLNQ
460 470 480 490 500
DQVDHLNSPI SPKEIEAVIN SLPTKKSPGP DGFSAEFYQT FKEDLIPILH
510 520 530 540 550
KLFHKIEVEG TLPNSFYEAT ITLIPKPQKD PTKIENFRPI SLMNIDAKIL
560 570 580 590 600
NKILANRIQE HIKAIIHPDQ VGFIPGMQGW FNIRKSINVI HYINKLKDKN
610 620 630 640 650
HMIISLDAEK AFDKIQHPFM IKVLERSGIQ GPYLNMIKAI YSKPVANIKV
660 670 680 690 700
NGEKLEAIPL KSGTRQGCPL SPYLFNIVLE VLARAIRQQK EIKGIQIGKE
710 720 730 740 750
EVKISLLADD MIVYISDPKN STRELLNLIN SFGEVVGYKI NSNKSMAFLY
760 770 780 790 800
TKNKQAEKEI RETTPFSIVT NNIKYLGVTL TKEVKDLYDK NFKSLKKEIK
810 820 830 840 850
EDLRRWKDLP CSWIGRINIV KMAILPKAIY RFNAIPIKIP TQFFNELEGA
860 870 880 890 900
ICKFVWNNKK PRIAKSLLKD KRTSGGITMP DLKLYYRAIV IKTAWYWYRD
910 920 930 940 950
RQVDQWNRIE DPEMNPHTYG HLIFDKGAKT IQWKKDSIFN NWCWHNWLLS
960 970 980 990 1000
CRRMRIDPYL SPCTKVKSKW IKELHIKPET LKLIEEKVGK SLEDMGTGEK
1010 1020 1030 1040 1050
FLNRTAMACA VRSRIDKWDL MKLQSFCKAK DTVNKTKRPP TDWERIFTYP
1060 1070 1080 1090 1100
KSDRGLISNI YKELKKVDFR KSNNPIKKWG SELNKEFSPE EYRMAEKHLK
1110 1120 1130 1140 1150
KCSTSLIIRE MQIKTTLRFH LTPVRMAKIK NSGDSRCWRG CGERGTLLHC
1160 1170 1180 1190 1200
WWECRLVQPL WKSVWRFLRK LDIVLPEDPA IPLLGIYPED APTGKKDTCS
1210 1220 1230 1240 1250
TMFIAALFII ARSWKEPRCP STEEWIQKMW YIYTMEYYSA IKKNEFMKFL
1260 1270 1280
AKWMDLEGII LSEVTHSQRN SHNMYSLISG Y
Length:1,281
Mass (Da):149,581
Last modified:February 1, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA6D2894DA364AB19
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA27363 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti86S → L in AAA67727 (PubMed:7533116).Curated1
Sequence conflicti246N → K in CAA27363 (PubMed:3008107).Curated1
Sequence conflicti359T → K in AAA67727 (PubMed:7533116).Curated1
Sequence conflicti707L → F in AAA67727 (PubMed:7533116).Curated1
Sequence conflicti736V → A in AAA67727 (PubMed:7533116).Curated1
Sequence conflicti761R → W in AAA67727 (PubMed:7533116).Curated1
Sequence conflicti928A → D in AAA67727 (PubMed:7533116).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M13002 Genomic DNA Translation: AAA66024.1
U15647 mRNA Translation: AAA67727.1
X03725 Genomic DNA Translation: CAA27363.1 Frameshift.

Protein sequence database of the Protein Information Resource

More...
PIRi
B58927 GNMSLL

Genome annotation databases

UCSC genome browser

More...
UCSCi
uc029qyg.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13002 Genomic DNA Translation: AAA66024.1
U15647 mRNA Translation: AAA67727.1
X03725 Genomic DNA Translation: CAA27363.1 Frameshift.
PIRiB58927 GNMSLL

3D structure databases

SMRiP11369
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000137421

PTM databases

PhosphoSitePlusiP11369
SwissPalmiP11369

Proteomic databases

PaxDbiP11369
PRIDEiP11369

Genome annotation databases

UCSCiuc029qyg.1 mouse

Phylogenomic databases

eggNOGiENOG410J1P7 Eukaryota
ENOG41120A8 LUCA
InParanoidiP11369

Family and domain databases

Gene3Di3.60.10.10, 1 hit
InterProiView protein in InterPro
IPR013544 DUF1725
IPR036691 Endo/exonu/phosph_ase_sf
IPR005135 Endo/exonuclease/phosphatase
IPR000477 RT_dom
PfamiView protein in Pfam
PF08333 DUF1725, 1 hit
PF03372 Exo_endo_phos, 1 hit
PF00078 RVT_1, 1 hit
SUPFAMiSSF56219 SSF56219, 1 hit
PROSITEiView protein in PROSITE
PS50878 RT_POL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLORF2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P11369
Secondary accession number(s): Q60713, Q61787
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: February 1, 2005
Last modified: October 16, 2019
This is version 108 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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