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Entry version 207 (13 Nov 2019)
Sequence version 6 (14 May 2014)
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Protein

Raf homolog serine/threonine-protein kinase Raf

Gene

Raf

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine/threonine kinase required in the early embryo for the formation of terminal structure (PubMed:3135183, PubMed:8423783). Also required during the proliferation of imaginal cells (PubMed:3135183). May act downstream of Ras85D in the tor signal transduction pathway (PubMed:8423783). During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis (PubMed:19965758).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

In quiescent cells, maintained in an inactive state via an intramolecular interaction between the protein kinase and N-terminal domains (By similarity). Following mitogen-mediated cell activation, binds via its RGB domain to active Ras85D (GTP-bound) which releases the inhibitory intramolecular interaction between the two domains (By similarity). This allows the Dsor1/MEK1-mediated dimerization of ksr and Raf which activates Raf (PubMed:29433126).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi220Zinc 1By similarity1
Metal bindingi236Zinc 2By similarity1
Metal bindingi239Zinc 2By similarity1
Metal bindingi249Zinc 1By similarity1
Metal bindingi252Zinc 1By similarity1
Metal bindingi257Zinc 2By similarity1
Metal bindingi260Zinc 2By similarity1
Metal bindingi268Zinc 1By similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei455ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei548Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri222 – 268Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST47
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi435 – 443ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAllosteric enzyme, Kinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

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BRENDAi
2.7.10.2 1994

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-DME-1295596 Spry regulation of FGF signaling
R-DME-170968 Frs2-mediated activation
R-DME-209190 Phosphorylation of CI
R-DME-209214 Phosphorylation of SMO
R-DME-392517 Rap1 signalling
R-DME-430116 GP1b-IX-V activation signalling
R-DME-432553 Phosphorylation of PER and TIM
R-DME-5621575 CD209 (DC-SIGN) signaling
R-DME-5673000 RAF activation
R-DME-5674135 MAP2K and MAPK activation
R-DME-5674499 Negative feedback regulation of MAPK pathway
R-DME-5675221 Negative regulation of MAPK pathway

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P11346

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Raf homolog serine/threonine-protein kinase Raf1 Publication (EC:2.7.11.1By similarity)
Short name:
D-Raf1 Publication
Short name:
dRAF-11 Publication
Alternative name(s):
Protein pole-holeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Raf1 PublicationImported
Synonyms:phImported, phlImported
ORF Names:CG2845Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

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FlyBasei
FBgn0003079 Raf

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

RNAi-mediated knockdown in the prothoracic gland (PG) delays the onset of pupariation by prolonging the L3 larval stage.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000861941 – 739Raf homolog serine/threonine-protein kinase RafAdd BLAST739

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei346Phosphoserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Extensively phosphorylated 1 to 2 hours after egg laying.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

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PRIDEi
P11346

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P11346

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed both maternally and zygotically. Zygotically expressed throughout embryogenesis.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
FBgn0003079 Expressed in 37 organ(s), highest expression level in embryo

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P11346 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with Dsor1/MEK1 and ksr; Dsor1 binding to ksr probably promotes ksr and Raf dimerization and ksr-mediated Raf transactivation.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
57758, 149 interactors

Database of interacting proteins

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DIPi
DIP-29769N

Protein interaction database and analysis system

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IntActi
P11346, 6 interactors

Molecular INTeraction database

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MINTi
P11346

STRING: functional protein association networks

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STRINGi
7227.FBpp0305946

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P11346

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini141 – 212RBDPROSITE-ProRule annotationAdd BLAST72
Domaini429 – 690Protein kinasePROSITE-ProRule annotationAdd BLAST262

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili50 – 86Sequence analysisAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi303 – 327Ser-richAdd BLAST25

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri222 – 268Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST47

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

Ensembl GeneTree

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GeneTreei
ENSGT00940000171269

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P11346

KEGG Orthology (KO)

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KOi
K04365

Identification of Orthologs from Complete Genome Data

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OMAi
NDIVFDF

Database of Orthologous Groups

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OrthoDBi
243095at2759

Family and domain databases

Conserved Domains Database

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CDDi
cd00029 C1, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR002219 PE/DAG-bd
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR003116 RBD_dom
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008271 Ser/Thr_kinase_AS
IPR029071 Ubiquitin-like_domsf

Pfam protein domain database

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Pfami
View protein in Pfam
PF00130 C1_1, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PF02196 RBD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00109 C1, 1 hit
SM00455 RBD, 1 hit
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF54236 SSF54236, 1 hit
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS50898 RBD, 1 hit
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P11346-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSESSTEGD SDLYDPLAEE LHNVQLVKHV TRENIDALNA KFANLQEPPA
60 70 80 90 100
MYLIEYQELT SKLHELEAKE QELMERLNSQ DQQEDSSLVE RFKEQPHYQN
110 120 130 140 150
QTQILQQQRQ LARVHHGNDL TDSLGSQPGS QCGTLTRQPK ILLRAHLPNQ
160 170 180 190 200
QRTSVEVISG VRLCDALMKA LKLRQLTPDM CEVSTTHSGR HIIPWHTDIG
210 220 230 240 250
TLHVEEIFVR LLDKFPIRTH IKHQIIRKTF FSLVFCEGCR RLLFTGFYCS
260 270 280 290 300
QCNFRFHQRC ANRVPMLCQP FPMDSYYQLL LAENPDNGVG FPGRGTAVRF
310 320 330 340 350
NMSSRSRSRR CSSSGSSSSS KPPSSSSGNH RQGRPPRISQ DDRSNSAPNV
360 370 380 390 400
CINNIRSVTS EVQRSLIMQA RPPLPHPCTD HSNSTQASPT STLKHNRPRA
410 420 430 440 450
RSADESNKNL LLRDAKSSEE NWNILAEEIL IGPRIGSGSF GTVYRAHWHG
460 470 480 490 500
PVAVKTLNVK TPSPAQLQAF KNEVAMLKKT RHCNILLFMG CVSKPSLAIV
510 520 530 540 550
TQWCEGSSLY KHVHVSETKF KLNTLIDIGR QVAQGMDYLH AKNIIHRDLK
560 570 580 590 600
SNNIFLHEDL SVKIGDFGLA TAKTRWSGEK QANQPTGSIL WMAPEVIRMQ
610 620 630 640 650
ELNPYSFQSD VYAFGIVMYE LLAECLPYGH ISNKDQILFM VGRGLLRPDM
660 670 680 690 700
SQVRSDAPQA LKRLAEDCIK YTPKDRPLFR PLLNMLENML RTLPKIHRSA
710 720 730
SEPNLTQSQL QNDEFLYLPS PKTPVNFNNF QFFGSAGNI
Length:739
Mass (Da):83,729
Last modified:May 14, 2014 - v6
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB685A895D05048C1
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA30166 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB72239 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti118N → T in CAA30166 (PubMed:3135183).Curated1
Sequence conflicti453A → P in CAA30166 (PubMed:3135183).Curated1
Sequence conflicti478 – 480KKT → RKA in M16598 (PubMed:3037346).Curated3
Sequence conflicti529G → R in M16598 (PubMed:3037346).Curated1
Sequence conflicti658 – 661PQAL → RRHS in CAA30166 (PubMed:3135183).Curated4

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti322P → L in strain: AA1. 1 Publication1
Natural varianti327S → T in strain: KLH4 and KLH6. 1 Publication1
Natural varianti360S → R in strain: Reids2. 1 Publication1
Natural varianti465A → T in strain: 5-17-88b#5. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X07181 Genomic DNA Translation: CAA30166.1 Sequence problems.
AE014298 Genomic DNA Translation: AAF45774.1
AE014298 Genomic DNA Translation: ABW09328.3
AL133503 Genomic DNA Translation: CAB72239.1 Sequence problems.
AY089490 mRNA Translation: AAL90228.1
AY135031 Genomic DNA Translation: AAN17541.1
AY135032 Genomic DNA Translation: AAN17542.1
AY135033 Genomic DNA Translation: AAN17543.1
AY135034 Genomic DNA Translation: AAN17544.1
AY135035 Genomic DNA Translation: AAN17545.1
AY135036 Genomic DNA Translation: AAN17546.1
AY135037 Genomic DNA Translation: AAN17547.1
AY135038 Genomic DNA Translation: AAN17548.1
AY135039 Genomic DNA Translation: AAN17549.1
AY135040 Genomic DNA Translation: AAN17550.1
AY135041 Genomic DNA Translation: AAN17551.1
AY135042 Genomic DNA Translation: AAN17552.1
AY135043 Genomic DNA Translation: AAN17553.1
AY135044 Genomic DNA Translation: AAN17554.1
AY135045 Genomic DNA Translation: AAN17555.1
AY135046 Genomic DNA Translation: AAN17556.1
AY135047 Genomic DNA Translation: AAN17557.1
AY135048 Genomic DNA Translation: AAN17558.1
AY135049 Genomic DNA Translation: AAN17559.1
AY135050 Genomic DNA Translation: AAN17560.1
AY135051 Genomic DNA Translation: AAN17561.1
AY135052 Genomic DNA Translation: AAN17562.1
M16598 Genomic DNA No translation available.

Protein sequence database of the Protein Information Resource

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PIRi
S00393 TVFFDF

NCBI Reference Sequences

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RefSeqi
NP_001096867.3, NM_001103397.3
NP_525047.1, NM_080308.4

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0070401; FBpp0070385; FBgn0003079
FBtr0344007; FBpp0310458; FBgn0003079

Database of genes from NCBI RefSeq genomes

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GeneIDi
31221

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG2845

UCSC genome browser

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UCSCi
CG2845-RB d. melanogaster
CG2845-RC d. melanogaster

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07181 Genomic DNA Translation: CAA30166.1 Sequence problems.
AE014298 Genomic DNA Translation: AAF45774.1
AE014298 Genomic DNA Translation: ABW09328.3
AL133503 Genomic DNA Translation: CAB72239.1 Sequence problems.
AY089490 mRNA Translation: AAL90228.1
AY135031 Genomic DNA Translation: AAN17541.1
AY135032 Genomic DNA Translation: AAN17542.1
AY135033 Genomic DNA Translation: AAN17543.1
AY135034 Genomic DNA Translation: AAN17544.1
AY135035 Genomic DNA Translation: AAN17545.1
AY135036 Genomic DNA Translation: AAN17546.1
AY135037 Genomic DNA Translation: AAN17547.1
AY135038 Genomic DNA Translation: AAN17548.1
AY135039 Genomic DNA Translation: AAN17549.1
AY135040 Genomic DNA Translation: AAN17550.1
AY135041 Genomic DNA Translation: AAN17551.1
AY135042 Genomic DNA Translation: AAN17552.1
AY135043 Genomic DNA Translation: AAN17553.1
AY135044 Genomic DNA Translation: AAN17554.1
AY135045 Genomic DNA Translation: AAN17555.1
AY135046 Genomic DNA Translation: AAN17556.1
AY135047 Genomic DNA Translation: AAN17557.1
AY135048 Genomic DNA Translation: AAN17558.1
AY135049 Genomic DNA Translation: AAN17559.1
AY135050 Genomic DNA Translation: AAN17560.1
AY135051 Genomic DNA Translation: AAN17561.1
AY135052 Genomic DNA Translation: AAN17562.1
M16598 Genomic DNA No translation available.
PIRiS00393 TVFFDF
RefSeqiNP_001096867.3, NM_001103397.3
NP_525047.1, NM_080308.4

3D structure databases

SMRiP11346
ModBaseiSearch...

Protein-protein interaction databases

BioGridi57758, 149 interactors
DIPiDIP-29769N
IntActiP11346, 6 interactors
MINTiP11346
STRINGi7227.FBpp0305946

PTM databases

iPTMnetiP11346

Proteomic databases

PRIDEiP11346

Genome annotation databases

EnsemblMetazoaiFBtr0070401; FBpp0070385; FBgn0003079
FBtr0344007; FBpp0310458; FBgn0003079
GeneIDi31221
KEGGidme:Dmel_CG2845
UCSCiCG2845-RB d. melanogaster
CG2845-RC d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
31221
FlyBaseiFBgn0003079 Raf

Phylogenomic databases

GeneTreeiENSGT00940000171269
InParanoidiP11346
KOiK04365
OMAiNDIVFDF
OrthoDBi243095at2759

Enzyme and pathway databases

BRENDAi2.7.10.2 1994
ReactomeiR-DME-1295596 Spry regulation of FGF signaling
R-DME-170968 Frs2-mediated activation
R-DME-209190 Phosphorylation of CI
R-DME-209214 Phosphorylation of SMO
R-DME-392517 Rap1 signalling
R-DME-430116 GP1b-IX-V activation signalling
R-DME-432553 Phosphorylation of PER and TIM
R-DME-5621575 CD209 (DC-SIGN) signaling
R-DME-5673000 RAF activation
R-DME-5674135 MAP2K and MAPK activation
R-DME-5674499 Negative feedback regulation of MAPK pathway
R-DME-5675221 Negative regulation of MAPK pathway
SignaLinkiP11346

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
phr fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
31221

Protein Ontology

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PROi
PR:P11346

Gene expression databases

BgeeiFBgn0003079 Expressed in 37 organ(s), highest expression level in embryo
GenevisibleiP11346 DM

Family and domain databases

CDDicd00029 C1, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR002219 PE/DAG-bd
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR003116 RBD_dom
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008271 Ser/Thr_kinase_AS
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF00130 C1_1, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PF02196 RBD, 1 hit
SMARTiView protein in SMART
SM00109 C1, 1 hit
SM00455 RBD, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS50898 RBD, 1 hit
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKRAF1_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P11346
Secondary accession number(s): A8JUV5
, Q0KHW7, Q8I086, Q8I0D9, Q8ISE1, Q8ISE2, Q8ISE3, Q9NEH9, Q9W4Z3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: May 14, 2014
Last modified: November 13, 2019
This is version 207 of the entry and version 6 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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