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Protein

Tyrosinase

Gene

Tyr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone (PubMed:2494997, PubMed:2517217, PubMed:1537333).3 Publications

Catalytic activityi

2 L-dopa + O2 = 2 dopaquinone + 2 H2O.1 Publication
L-tyrosine + O2 = dopaquinone + H2O.1 Publication

Cofactori

Cu2+By similarityNote: Binds 2 copper ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi180Copper ABy similarity1
Metal bindingi202Copper ABy similarity1
Metal bindingi211Copper ABy similarity1
Metal bindingi363Copper BBy similarity1
Metal bindingi367Copper BBy similarity1
Metal bindingi390Copper BBy similarity1

GO - Molecular functioni

GO - Biological processi

  • cell proliferation Source: MGI
  • melanin biosynthetic process Source: MGI
  • pigmentation Source: MGI
  • response to cAMP Source: Ensembl
  • response to UV Source: GO_Central
  • response to vitamin D Source: GO_Central
  • thymus development Source: MGI

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
Biological processMelanin biosynthesis
LigandCopper, Metal-binding

Enzyme and pathway databases

BRENDAi1.14.18.1 3474
ReactomeiR-MMU-5662702 Melanin biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosinase (EC:1.14.18.1)
Alternative name(s):
Albino locus protein
Monophenol monooxygenase
Gene namesi
Name:Tyr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:98880 Tyr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 476Lumenal, melanosomeSequence analysisAdd BLAST458
Transmembranei477 – 497HelicalSequence analysisAdd BLAST21
Topological domaini498 – 533CytoplasmicSequence analysisAdd BLAST36

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Defects in Tyr result in various forms of albinism. Himalayan strain tyrosinase is temperature-sensitive.4 Publications

Keywords - Diseasei

Albinism, Disease mutation

Chemistry databases

ChEMBLiCHEMBL5346

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000003588019 – 533TyrosinaseAdd BLAST515

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi86N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi111N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi161N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi230N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi337N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi371N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP11344
PRIDEiP11344

PTM databases

PhosphoSitePlusiP11344

Expressioni

Gene expression databases

BgeeiENSMUSG00000004651 Expressed in 82 organ(s), highest expression level in iris
CleanExiMM_TYR
ExpressionAtlasiP11344 baseline and differential
GenevisibleiP11344 MM

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Tyrp1P071472EBI-821603,EBI-821614

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204394, 7 interactors
ELMiP11344
IntActiP11344, 1 interactor
STRINGi10090.ENSMUSP00000004770

Chemistry databases

BindingDBiP11344

Structurei

3D structure databases

ProteinModelPortaliP11344
SMRiP11344
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi503 – 508Poly-Lys6

Sequence similaritiesi

Belongs to the tyrosinase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEZU Eukaryota
ENOG410Y42I LUCA
GeneTreeiENSGT00500000044790
HOGENOMiHOG000118376
HOVERGENiHBG003553
InParanoidiP11344
KOiK00505
OMAiPNCTEKR
OrthoDBiEOG091G03YR
PhylomeDBiP11344
TreeFamiTF315865

Family and domain databases

Gene3Di1.10.1280.10, 1 hit
InterProiView protein in InterPro
IPR002227 Tyrosinase_Cu-bd
IPR008922 Unchr_di-copper_centre
PfamiView protein in Pfam
PF00264 Tyrosinase, 1 hit
PRINTSiPR00092 TYROSINASE
SUPFAMiSSF48056 SSF48056, 1 hit
PROSITEiView protein in PROSITE
PS00497 TYROSINASE_1, 1 hit
PS00498 TYROSINASE_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P11344-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFLAVLYCLL WSFQISDGHF PRACASSKNL LAKECCPPWM GDGSPCGQLS
60 70 80 90 100
GRGSCQDILL SSAPSGPQFP FKGVDDRESW PSVFYNRTCQ CSGNFMGFNC
110 120 130 140 150
GNCKFGFGGP NCTEKRVLIR RNIFDLSVSE KNKFFSYLTL AKHTISSVYV
160 170 180 190 200
IPTGTYGQMN NGSTPMFNDI NIYDLFVWMH YYVSRDTLLG GSEIWRDIDF
210 220 230 240 250
AHEAPGFLPW HRLFLLLWEQ EIRELTGDEN FTVPYWDWRD AENCDICTDE
260 270 280 290 300
YLGGRHPENP NLLSPASFFS SWQIICSRSE EYNSHQVLCD GTPEGPLLRN
310 320 330 340 350
PGNHDKAKTP RLPSSADVEF CLSLTQYESG SMDRTANFSF RNTLEGFASP
360 370 380 390 400
LTGIADPSQS SMHNALHIFM NGTMSQVQGS ANDPIFLLHH AFVDSIFEQW
410 420 430 440 450
LRRHRPLLEV YPEANAPIGH NRDSYMVPFI PLYRNGDFFI TSKDLGYDYS
460 470 480 490 500
YLQESDPGFY RNYIEPYLEQ ASRIWPWLLG AALVGAVIAA ALSGLSSRLC
510 520 530
LQKKKKKKQP QEERQPLLMD KDDYHSLLYQ SHL
Length:533
Mass (Da):60,606
Last modified:May 29, 2007 - v3
Checksum:iA4C109A97CBD5D6A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A140LIB9A0A140LIB9_MOUSE
Tyrosinase
Tyr
158Annotation score:

Sequence cautioni

The sequence BAA00079 differs from that shown.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti40M → I in AAA37806 (PubMed:2567165).Curated1
Sequence conflicti197D → Q in AAA37806 (PubMed:2567165).Curated1
Sequence conflicti264S → I in CAA31273 (PubMed:3141148).Curated1
Sequence conflicti346G → V in AAA40516 (PubMed:3134020).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti103C → S in albino mice. 3 Publications1
Natural varianti420H → R in strain: Himalayan. 1 Publication1
Natural varianti482A → T in chinchilla mice. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00440 mRNA Translation: BAA00341.1
D00131 mRNA Translation: BAA00079.1 Sequence problems.
M20234 mRNA Translation: AAA40516.1
X12782 mRNA Translation: CAA31273.1
M26729 mRNA Translation: AAA37806.1
M24560 mRNA Translation: AAA40517.1
D00439 Genomic DNA Translation: BAA00340.1
X51743 Genomic DNA Translation: CAA36033.1
CCDSiCCDS52304.1
PIRiA27711 YRMSCS
RefSeqiNP_035791.1, NM_011661.5
UniGeneiMm.238127

Genome annotation databases

EnsembliENSMUST00000004770; ENSMUSP00000004770; ENSMUSG00000004651
GeneIDi22173
KEGGimmu:22173
UCSCiuc009ifo.1 mouse

Similar proteinsi

Cross-referencesi

Web resourcesi

Protein Spotlight

Snowy stardom - Issue 49 of August 2004

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00440 mRNA Translation: BAA00341.1
D00131 mRNA Translation: BAA00079.1 Sequence problems.
M20234 mRNA Translation: AAA40516.1
X12782 mRNA Translation: CAA31273.1
M26729 mRNA Translation: AAA37806.1
M24560 mRNA Translation: AAA40517.1
D00439 Genomic DNA Translation: BAA00340.1
X51743 Genomic DNA Translation: CAA36033.1
CCDSiCCDS52304.1
PIRiA27711 YRMSCS
RefSeqiNP_035791.1, NM_011661.5
UniGeneiMm.238127

3D structure databases

ProteinModelPortaliP11344
SMRiP11344
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204394, 7 interactors
ELMiP11344
IntActiP11344, 1 interactor
STRINGi10090.ENSMUSP00000004770

Chemistry databases

BindingDBiP11344
ChEMBLiCHEMBL5346

PTM databases

PhosphoSitePlusiP11344

Proteomic databases

PaxDbiP11344
PRIDEiP11344

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000004770; ENSMUSP00000004770; ENSMUSG00000004651
GeneIDi22173
KEGGimmu:22173
UCSCiuc009ifo.1 mouse

Organism-specific databases

CTDi7299
MGIiMGI:98880 Tyr

Phylogenomic databases

eggNOGiENOG410IEZU Eukaryota
ENOG410Y42I LUCA
GeneTreeiENSGT00500000044790
HOGENOMiHOG000118376
HOVERGENiHBG003553
InParanoidiP11344
KOiK00505
OMAiPNCTEKR
OrthoDBiEOG091G03YR
PhylomeDBiP11344
TreeFamiTF315865

Enzyme and pathway databases

BRENDAi1.14.18.1 3474
ReactomeiR-MMU-5662702 Melanin biosynthesis

Miscellaneous databases

PROiPR:P11344
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000004651 Expressed in 82 organ(s), highest expression level in iris
CleanExiMM_TYR
ExpressionAtlasiP11344 baseline and differential
GenevisibleiP11344 MM

Family and domain databases

Gene3Di1.10.1280.10, 1 hit
InterProiView protein in InterPro
IPR002227 Tyrosinase_Cu-bd
IPR008922 Unchr_di-copper_centre
PfamiView protein in Pfam
PF00264 Tyrosinase, 1 hit
PRINTSiPR00092 TYROSINASE
SUPFAMiSSF48056 SSF48056, 1 hit
PROSITEiView protein in PROSITE
PS00497 TYROSINASE_1, 1 hit
PS00498 TYROSINASE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTYRO_MOUSE
AccessioniPrimary (citable) accession number: P11344
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: May 29, 2007
Last modified: November 7, 2018
This is version 177 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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