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Protein

Medium-chain specific acyl-CoA dehydrogenase, mitochondrial

Gene

ACADM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acyl-CoA dehydrogenase specific for acyl chain lengths of 4 to 16 that catalyzes the initial step of fatty acid beta-oxidation. Utilizes the electron transfer flavoprotein (ETF) as an electron acceptor to transfer electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).1 Publication

Miscellaneous

A number of straight-chain acyl-CoA dehydrogenases of different substrate specificities are present in mammalian tissues.

Catalytic activityi

A medium-chain acyl-CoA + electron-transfer flavoprotein = a medium-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein.

Cofactori

FAD1 Publication

Pathwayi: mitochondrial fatty acid beta-oxidation

This protein is involved in the pathway mitochondrial fatty acid beta-oxidation, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway mitochondrial fatty acid beta-oxidation and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei167Substrate; via carbonyl oxygen1
Binding sitei216Substrate1
Active sitei401Proton acceptor1
Binding sitei402Substrate; via amide nitrogen1
Binding sitei413Substrate1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi158 – 167FAD1 Publication10
Nucleotide bindingi191 – 193FAD1 Publication3
Nucleotide bindingi306 – 308FAD1 Publication3
Nucleotide bindingi316 – 317FAD1 Publication2
Nucleotide bindingi374 – 378FAD1 Publication5
Nucleotide bindingi403 – 405FAD1 Publication3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid metabolism, Lipid metabolism
LigandFAD, Flavoprotein

Enzyme and pathway databases

BioCyciMetaCyc:HS04089-MONOMER
ReactomeiR-HSA-1989781 PPARA activates gene expression
R-HSA-77288 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids
R-HSA-77346 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA
R-HSA-77348 Beta oxidation of octanoyl-CoA to hexanoyl-CoA
SABIO-RKiP11310
UniPathwayi
UPA00660

Chemistry databases

SwissLipidsiSLP:000001334

Names & Taxonomyi

Protein namesi
Recommended name:
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (EC:1.3.8.7)
Short name:
MCAD
Gene namesi
Name:ACADM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000117054.13
HGNCiHGNC:89 ACADM
MIMi607008 gene
neXtProtiNX_P11310

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Involvement in diseasei

Acyl-CoA dehydrogenase medium-chain deficiency (ACADMD)16 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn inborn error of mitochondrial fatty acid beta-oxidation which causes fasting hypoglycemia, hepatic dysfunction and encephalopathy, often resulting in death in infancy.
See also OMIM:201450
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00031753R → C in ACADMD. Corresponds to variant dbSNP:rs398123072EnsemblClinVar.1
Natural variantiVAR_01369867Y → H in ACADMD; mild. 1 PublicationCorresponds to variant dbSNP:rs121434280EnsemblClinVar.1
Natural variantiVAR_01595478I → T in ACADMD. 1 PublicationCorresponds to variant dbSNP:rs398123074EnsemblClinVar.1
Natural variantiVAR_000318115 – 116Missing in ACADMD. 1 Publication2
Natural variantiVAR_015955116C → Y in ACADMD. 1 PublicationCorresponds to variant dbSNP:rs875989859EnsemblClinVar.1
Natural variantiVAR_015956121T → I in ACADMD. 1 PublicationCorresponds to variant dbSNP:rs121434283EnsemblClinVar.1
Natural variantiVAR_000319149M → I in ACADMD. 1 PublicationCorresponds to variant dbSNP:rs121434277EnsemblClinVar.1
Natural variantiVAR_000320193T → A in ACADMD; the thermostability is markedly decreased. 2 PublicationsCorresponds to variant dbSNP:rs121434279EnsemblClinVar.1
Natural variantiVAR_000321195G → R in ACADMD. 1 PublicationCorresponds to variant dbSNP:rs121434278EnsemblClinVar.1
Natural variantiVAR_015957206R → L in ACADMD. 1 Publication1
Natural variantiVAR_000322244C → R in ACADMD. 1 PublicationCorresponds to variant dbSNP:rs121434276EnsemblClinVar.1
Natural variantiVAR_013699245S → L in ACADMD. 1 PublicationCorresponds to variant dbSNP:rs121434281EnsemblClinVar.1
Natural variantiVAR_000323267G → R in ACADMD. 1 PublicationCorresponds to variant dbSNP:rs121434274EnsemblClinVar.1
Natural variantiVAR_013700281R → T in ACADMD; mild or benign clinical phenotype. 1 PublicationCorresponds to variant dbSNP:rs121434282EnsemblClinVar.1
Natural variantiVAR_015958310G → R in ACADMD. 1 PublicationCorresponds to variant dbSNP:rs747268471EnsemblClinVar.1
Natural variantiVAR_000324326M → T in ACADMD. 1 PublicationCorresponds to variant dbSNP:rs786204631EnsemblClinVar.1
Natural variantiVAR_000325329K → E in ACADMD; most common variant. 6 PublicationsCorresponds to variant dbSNP:rs77931234Ensembl.1
Natural variantiVAR_000326336S → R in ACADMD. 1 Publication1
Natural variantiVAR_015959352Y → C in ACADMD. 1 Publication1
Natural variantiVAR_000327375I → T in ACADMD. 1 PublicationCorresponds to variant dbSNP:rs121434275EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi86L → M: Strongly reduced rate of electron transfer to ETF. 1 Publication1
Mutagenesisi98L → W: Strongly reduced rate of electron transfer to ETF. 1 Publication1
Mutagenesisi100L → Y: Strongly reduced rate of electron transfer to ETF. 1 Publication1
Mutagenesisi108I → M: Strongly reduced rate of electron transfer to ETF. 1 Publication1
Mutagenesisi191W → A: Loss of electron transfer to ETF. 1 Publication1
Mutagenesisi191W → F: Reduces rate of electron transfer to ETF about six-fold. 1 Publication1
Mutagenesisi237E → A: Strongly reduced rate of electron transfer to ETF. 2 Publications1
Mutagenesisi384E → A: Reduces rate of electron transfer to ETF three-fold. 2 Publications1
Mutagenesisi384E → Q: Reduces rate of electron transfer to ETF two-fold. 2 Publications1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi34
GeneReviewsiACADM
MalaCardsiACADM
MIMi201450 phenotype
OpenTargetsiENSG00000117054
Orphaneti42 Medium chain acyl-CoA dehydrogenase deficiency
PharmGKBiPA24425

Chemistry databases

DrugBankiDB03415 3-Thiaoctanoyl-Coenzyme A
DB03147 Flavin adenine dinucleotide
DB02910 Octanoyl-Coenzyme A

Polymorphism and mutation databases

BioMutaiACADM
DMDMi113017

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 25MitochondrionAdd BLAST25
ChainiPRO_000000050226 – 421Medium-chain specific acyl-CoA dehydrogenase, mitochondrialAdd BLAST396

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei69N6-acetyllysine; alternateBy similarity1
Modified residuei69N6-succinyllysine; alternateBy similarity1
Modified residuei179N6-succinyllysineBy similarity1
Modified residuei212N6-acetyllysine; alternateBy similarity1
Modified residuei212N6-succinyllysine; alternateBy similarity1
Modified residuei217N6-acetyllysine; alternateBy similarity1
Modified residuei217N6-succinyllysine; alternateBy similarity1
Modified residuei259N6-acetyllysine; alternateBy similarity1
Modified residuei259N6-succinyllysine; alternateBy similarity1
Modified residuei271N6-acetyllysine; alternateBy similarity1
Modified residuei271N6-succinyllysine; alternateBy similarity1
Modified residuei279N6-acetyllysineCombined sources1
Modified residuei301N6-acetyllysineCombined sources1
Modified residuei351PhosphothreonineBy similarity1

Post-translational modificationi

Acetylation at Lys-307 and Lys-311 in proximity of the cofactor-binding sites reduces catalytic activity (By similarity). These sites are deacetylated by SIRT3.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP11310
MaxQBiP11310
PaxDbiP11310
PeptideAtlasiP11310
PRIDEiP11310
ProteomicsDBi52743
52744 [P11310-2]

2D gel databases

REPRODUCTION-2DPAGEiIPI00005040
UCD-2DPAGEiP11310

PTM databases

iPTMnetiP11310
PhosphoSitePlusiP11310
SwissPalmiP11310

Expressioni

Gene expression databases

BgeeiENSG00000117054 Expressed in 237 organ(s), highest expression level in skeletal muscle tissue of rectus abdominis
CleanExiHS_ACADM
ExpressionAtlasiP11310 baseline and differential
GenevisibleiP11310 HS

Organism-specific databases

HPAiHPA006198
HPA026542

Interactioni

Subunit structurei

Homotetramer. Interacts with the heterodimeric electron transfer flavoprotein ETF.3 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi106552, 50 interactors
DIPiDIP-34281N
IntActiP11310, 14 interactors
MINTiP11310
STRINGi9606.ENSP00000409612

Structurei

Secondary structure

1421
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP11310
SMRiP11310
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP11310

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni278 – 281Substrate binding4

Sequence similaritiesi

Belongs to the acyl-CoA dehydrogenase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0140 Eukaryota
COG1960 LUCA
GeneTreeiENSGT00760000119007
HOGENOMiHOG000131659
HOVERGENiHBG000224
InParanoidiP11310
KOiK00249
PhylomeDBiP11310
TreeFamiTF105020

Family and domain databases

CDDicd01157 MCAD, 1 hit
Gene3Di1.10.540.10, 1 hit
InterProiView protein in InterPro
IPR006089 Acyl-CoA_DH_CS
IPR006091 Acyl-CoA_Oxase/DH_cen-dom
IPR036250 AcylCo_DH-like_C
IPR009075 AcylCo_DH/oxidase_C
IPR013786 AcylCoA_DH/ox_N
IPR037069 AcylCoA_DH/ox_N_sf
IPR009100 AcylCoA_DH/oxidase_NM_dom
IPR034180 MCAD
PfamiView protein in Pfam
PF00441 Acyl-CoA_dh_1, 1 hit
PF02770 Acyl-CoA_dh_M, 1 hit
PF02771 Acyl-CoA_dh_N, 1 hit
SUPFAMiSSF47203 SSF47203, 1 hit
SSF56645 SSF56645, 1 hit
PROSITEiView protein in PROSITE
PS00072 ACYL_COA_DH_1, 1 hit
PS00073 ACYL_COA_DH_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P11310-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAGFGRCCR VLRSISRFHW RSQHTKANRQ REPGLGFSFE FTEQQKEFQA
60 70 80 90 100
TARKFAREEI IPVAAEYDKT GEYPVPLIRR AWELGLMNTH IPENCGGLGL
110 120 130 140 150
GTFDACLISE ELAYGCTGVQ TAIEGNSLGQ MPIIIAGNDQ QKKKYLGRMT
160 170 180 190 200
EEPLMCAYCV TEPGAGSDVA GIKTKAEKKG DEYIINGQKM WITNGGKANW
210 220 230 240 250
YFLLARSDPD PKAPANKAFT GFIVEADTPG IQIGRKELNM GQRCSDTRGI
260 270 280 290 300
VFEDVKVPKE NVLIGDGAGF KVAMGAFDKT RPVVAAGAVG LAQRALDEAT
310 320 330 340 350
KYALERKTFG KLLVEHQAIS FMLAEMAMKV ELARMSYQRA AWEVDSGRRN
360 370 380 390 400
TYYASIAKAF AGDIANQLAT DAVQILGGNG FNTEYPVEKL MRDAKIYQIY
410 420
EGTSQIQRLI VAREHIDKYK N
Length:421
Mass (Da):46,588
Last modified:July 1, 1989 - v1
Checksum:i7CD0B5832410581B
GO
Isoform 2 (identifier: P11310-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     10-10: R → RCSLQ

Show »
Length:425
Mass (Da):47,020
Checksum:iC6A133404E1B6E70
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T4U5Q5T4U5_HUMAN
Acyl-Coenzyme A dehydrogenase, C-4 ...
ACADM hCG_22915
454Annotation score:
B7Z9I1B7Z9I1_HUMAN
Medium-chain-specific acyl-CoA dehy...
ACADM
385Annotation score:
E9PJM9E9PJM9_HUMAN
Medium-chain-specific acyl-CoA dehy...
ACADM
104Annotation score:
E9PRX4E9PRX4_HUMAN
Medium-chain-specific acyl-CoA dehy...
ACADM
76Annotation score:
H0YDT5H0YDT5_HUMAN
Medium-chain-specific acyl-CoA dehy...
ACADM
67Annotation score:
E9PQA8E9PQA8_HUMAN
Medium-chain-specific acyl-CoA dehy...
ACADM
45Annotation score:
E9PLN7E9PLN7_HUMAN
Medium-chain-specific acyl-CoA dehy...
ACADM
50Annotation score:
E9PIX8E9PIX8_HUMAN
Acyl-CoA dehydrogenase C-4 to C-12 ...
ACADM
47Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti356I → T in AAF63626 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00031753R → C in ACADMD. Corresponds to variant dbSNP:rs398123072EnsemblClinVar.1
Natural variantiVAR_01369867Y → H in ACADMD; mild. 1 PublicationCorresponds to variant dbSNP:rs121434280EnsemblClinVar.1
Natural variantiVAR_01595478I → T in ACADMD. 1 PublicationCorresponds to variant dbSNP:rs398123074EnsemblClinVar.1
Natural variantiVAR_000318115 – 116Missing in ACADMD. 1 Publication2
Natural variantiVAR_015955116C → Y in ACADMD. 1 PublicationCorresponds to variant dbSNP:rs875989859EnsemblClinVar.1
Natural variantiVAR_015956121T → I in ACADMD. 1 PublicationCorresponds to variant dbSNP:rs121434283EnsemblClinVar.1
Natural variantiVAR_035716132P → R in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs875989854EnsemblClinVar.1
Natural variantiVAR_000319149M → I in ACADMD. 1 PublicationCorresponds to variant dbSNP:rs121434277EnsemblClinVar.1
Natural variantiVAR_000320193T → A in ACADMD; the thermostability is markedly decreased. 2 PublicationsCorresponds to variant dbSNP:rs121434279EnsemblClinVar.1
Natural variantiVAR_000321195G → R in ACADMD. 1 PublicationCorresponds to variant dbSNP:rs121434278EnsemblClinVar.1
Natural variantiVAR_015957206R → L in ACADMD. 1 Publication1
Natural variantiVAR_000322244C → R in ACADMD. 1 PublicationCorresponds to variant dbSNP:rs121434276EnsemblClinVar.1
Natural variantiVAR_013699245S → L in ACADMD. 1 PublicationCorresponds to variant dbSNP:rs121434281EnsemblClinVar.1
Natural variantiVAR_000323267G → R in ACADMD. 1 PublicationCorresponds to variant dbSNP:rs121434274EnsemblClinVar.1
Natural variantiVAR_013700281R → T in ACADMD; mild or benign clinical phenotype. 1 PublicationCorresponds to variant dbSNP:rs121434282EnsemblClinVar.1
Natural variantiVAR_015958310G → R in ACADMD. 1 PublicationCorresponds to variant dbSNP:rs747268471EnsemblClinVar.1
Natural variantiVAR_000324326M → T in ACADMD. 1 PublicationCorresponds to variant dbSNP:rs786204631EnsemblClinVar.1
Natural variantiVAR_000325329K → E in ACADMD; most common variant. 6 PublicationsCorresponds to variant dbSNP:rs77931234Ensembl.1
Natural variantiVAR_000326336S → R in ACADMD. 1 Publication1
Natural variantiVAR_015959352Y → C in ACADMD. 1 Publication1
Natural variantiVAR_000327375I → T in ACADMD. 1 PublicationCorresponds to variant dbSNP:rs121434275EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03842010R → RCSLQ in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16827 mRNA Translation: AAA51566.1
M91432
, M91421, M91422, M91423, M91425, M91426, M91427, M91428, M91429, M91430, M91431 Genomic DNA Translation: AAA59567.1
AF251043 mRNA Translation: AAF63626.1
AK312629 mRNA Translation: BAG35514.1
AL357314 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06401.1
BC005377 mRNA Translation: AAH05377.1
M60505 Genomic DNA Translation: AAB59625.1
CCDSiCCDS44165.1 [P11310-2]
CCDS668.1 [P11310-1]
PIRiA29031 DEHUCM
RefSeqiNP_000007.1, NM_000016.5 [P11310-1]
NP_001120800.1, NM_001127328.2 [P11310-2]
UniGeneiHs.445040

Genome annotation databases

EnsembliENST00000370841; ENSP00000359878; ENSG00000117054 [P11310-1]
ENST00000420607; ENSP00000409612; ENSG00000117054 [P11310-2]
GeneIDi34
KEGGihsa:34
UCSCiuc001dgw.6 human [P11310-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16827 mRNA Translation: AAA51566.1
M91432
, M91421, M91422, M91423, M91425, M91426, M91427, M91428, M91429, M91430, M91431 Genomic DNA Translation: AAA59567.1
AF251043 mRNA Translation: AAF63626.1
AK312629 mRNA Translation: BAG35514.1
AL357314 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06401.1
BC005377 mRNA Translation: AAH05377.1
M60505 Genomic DNA Translation: AAB59625.1
CCDSiCCDS44165.1 [P11310-2]
CCDS668.1 [P11310-1]
PIRiA29031 DEHUCM
RefSeqiNP_000007.1, NM_000016.5 [P11310-1]
NP_001120800.1, NM_001127328.2 [P11310-2]
UniGeneiHs.445040

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EGCX-ray2.60A/B/C/D26-421[»]
1EGDX-ray2.40A/B/C/D26-421[»]
1EGEX-ray2.75A/B/C/D26-421[»]
1T9GX-ray2.90A/B/C/D26-421[»]
2A1TX-ray2.80A/B/C/D1-421[»]
4P13X-ray1.73A/B/C/D35-421[»]
ProteinModelPortaliP11310
SMRiP11310
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106552, 50 interactors
DIPiDIP-34281N
IntActiP11310, 14 interactors
MINTiP11310
STRINGi9606.ENSP00000409612

Chemistry databases

DrugBankiDB03415 3-Thiaoctanoyl-Coenzyme A
DB03147 Flavin adenine dinucleotide
DB02910 Octanoyl-Coenzyme A
SwissLipidsiSLP:000001334

PTM databases

iPTMnetiP11310
PhosphoSitePlusiP11310
SwissPalmiP11310

Polymorphism and mutation databases

BioMutaiACADM
DMDMi113017

2D gel databases

REPRODUCTION-2DPAGEiIPI00005040
UCD-2DPAGEiP11310

Proteomic databases

EPDiP11310
MaxQBiP11310
PaxDbiP11310
PeptideAtlasiP11310
PRIDEiP11310
ProteomicsDBi52743
52744 [P11310-2]

Protocols and materials databases

DNASUi34
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370841; ENSP00000359878; ENSG00000117054 [P11310-1]
ENST00000420607; ENSP00000409612; ENSG00000117054 [P11310-2]
GeneIDi34
KEGGihsa:34
UCSCiuc001dgw.6 human [P11310-1]

Organism-specific databases

CTDi34
DisGeNETi34
EuPathDBiHostDB:ENSG00000117054.13
GeneCardsiACADM
GeneReviewsiACADM
HGNCiHGNC:89 ACADM
HPAiHPA006198
HPA026542
MalaCardsiACADM
MIMi201450 phenotype
607008 gene
neXtProtiNX_P11310
OpenTargetsiENSG00000117054
Orphaneti42 Medium chain acyl-CoA dehydrogenase deficiency
PharmGKBiPA24425
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0140 Eukaryota
COG1960 LUCA
GeneTreeiENSGT00760000119007
HOGENOMiHOG000131659
HOVERGENiHBG000224
InParanoidiP11310
KOiK00249
PhylomeDBiP11310
TreeFamiTF105020

Enzyme and pathway databases

UniPathwayi
UPA00660

BioCyciMetaCyc:HS04089-MONOMER
ReactomeiR-HSA-1989781 PPARA activates gene expression
R-HSA-77288 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids
R-HSA-77346 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA
R-HSA-77348 Beta oxidation of octanoyl-CoA to hexanoyl-CoA
SABIO-RKiP11310

Miscellaneous databases

ChiTaRSiACADM human
EvolutionaryTraceiP11310
GenomeRNAii34
PROiPR:P11310
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000117054 Expressed in 237 organ(s), highest expression level in skeletal muscle tissue of rectus abdominis
CleanExiHS_ACADM
ExpressionAtlasiP11310 baseline and differential
GenevisibleiP11310 HS

Family and domain databases

CDDicd01157 MCAD, 1 hit
Gene3Di1.10.540.10, 1 hit
InterProiView protein in InterPro
IPR006089 Acyl-CoA_DH_CS
IPR006091 Acyl-CoA_Oxase/DH_cen-dom
IPR036250 AcylCo_DH-like_C
IPR009075 AcylCo_DH/oxidase_C
IPR013786 AcylCoA_DH/ox_N
IPR037069 AcylCoA_DH/ox_N_sf
IPR009100 AcylCoA_DH/oxidase_NM_dom
IPR034180 MCAD
PfamiView protein in Pfam
PF00441 Acyl-CoA_dh_1, 1 hit
PF02770 Acyl-CoA_dh_M, 1 hit
PF02771 Acyl-CoA_dh_N, 1 hit
SUPFAMiSSF47203 SSF47203, 1 hit
SSF56645 SSF56645, 1 hit
PROSITEiView protein in PROSITE
PS00072 ACYL_COA_DH_1, 1 hit
PS00073 ACYL_COA_DH_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiACADM_HUMAN
AccessioniPrimary (citable) accession number: P11310
Secondary accession number(s): Q5T4U4, Q9NYF1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: September 12, 2018
This is version 208 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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