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Protein

Transcriptional regulator ERG

Gene

ERG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi318 – 398ETSPROSITE-ProRule annotationAdd BLAST81

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P11308

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P11308

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcriptional regulator ERG
Alternative name(s):
Transforming protein ERG
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ERG
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000157554.18

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3446 ERG

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
165080 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P11308

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Ewing sarcoma (ES)1 Publication
The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving ERG has been found in patients with Erwing sarcoma. Translocation t(21;22)(q22;q12) with EWSR1.1 Publication
Disease descriptionA highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors.
See also OMIM:612219
Chromosomal aberrations involving ERG have been found in acute myeloid leukemia (AML). Translocation t(16;21)(p11;q22) with FUS (PubMed:8187069). Translocation t(X;21)(q25-26;q22) with ELF4 (PubMed:16303180).2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei469 – 470Breakpoint for translocation to form ELF4-ERG oncogene2

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNET

More...
DisGeNETi
2078

MalaCards human disease database

More...
MalaCardsi
ERG
MIMi612219 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000157554

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
319 Ewing sarcoma
370334 Extraskeletal Ewing sarcoma

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27858

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1293191

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ERG

Domain mapping of disease mutations (DMDM)

More...
DMDMi
152031600

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002041031 – 486Transcriptional regulator ERGAdd BLAST486

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei55PhosphoserineBy similarity1
Modified residuei88PhosphoserineBy similarity1
Modified residuei103PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki289Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P11308

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P11308

PeptideAtlas

More...
PeptideAtlasi
P11308

PRoteomics IDEntifications database

More...
PRIDEi
P11308

ProteomicsDB human proteome resource

More...
ProteomicsDBi
52735
52736 [P11308-1]
52737 [P11308-2]
52738 [P11308-4]
52739 [P11308-5]
52740 [P11308-6]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P11308-6 [P11308-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P11308

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P11308

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000157554 Expressed in 197 organ(s), highest expression level in tendon of biceps brachii

CleanEx database of gene expression profiles

More...
CleanExi
HS_ERG

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P11308 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P11308 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB018377
HPA046598

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with SETDB1.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108389, 94 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P11308

Database of interacting proteins

More...
DIPi
DIP-31028N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
P11308

Protein interaction database and analysis system

More...
IntActi
P11308, 17 interactors

Molecular INTeraction database

More...
MINTi
P11308

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000381891

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P11308

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1486
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SXENMR-A115-208[»]
4IRGX-ray1.70A313-412[»]
4IRHX-ray2.10A287-412[»]
4IRIX-ray2.77A287-412[»]
5YBCX-ray2.50A/C317-408[»]
5YBDX-ray2.77A/X317-406[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P11308

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P11308

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P11308

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini120 – 206PNTPROSITE-ProRule annotationAdd BLAST87

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ETS family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3806 Eukaryota
ENOG410Z0ZF LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160662

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG001553

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P11308

KEGG Orthology (KO)

More...
KOi
K09435

Identification of Orthologs from Complete Genome Data

More...
OMAi
EYGQTSK

Database of Orthologous Groups

More...
OrthoDBi
1568974at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P11308

TreeFam database of animal gene trees

More...
TreeFami
TF350537

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000418 Ets_dom
IPR003118 Pointed_dom
IPR013761 SAM/pointed_sf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00178 Ets, 1 hit
PF02198 SAM_PNT, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00454 ETSDOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00413 ETS, 1 hit
SM00251 SAM_PNT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785 SSF46785, 1 hit
SSF47769 SSF47769, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00345 ETS_DOMAIN_1, 1 hit
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit
PS51433 PNT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform ERG-3 (identifier: P11308-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIQTVPDPAA HIKEALSVVS EDQSLFECAY GTPHLAKTEM TASSSSDYGQ
60 70 80 90 100
TSKMSPRVPQ QDWLSQPPAR VTIKMECNPS QVNGSRNSPD ECSVAKGGKM
110 120 130 140 150
VGSPDTVGMN YGSYMEEKHM PPPNMTTNER RVIVPADPTL WSTDHVRQWL
160 170 180 190 200
EWAVKEYGLP DVNILLFQNI DGKELCKMTK DDFQRLTPSY NADILLSHLH
210 220 230 240 250
YLRETPLPHL TSDDVDKALQ NSPRLMHARN TGGAAFIFPN TSVYPEATQR
260 270 280 290 300
ITTRPDLPYE PPRRSAWTGH GHPTPQSKAA QPSPSTVPKT EDQRPQLDPY
310 320 330 340 350
QILGPTSSRL ANPGSGQIQL WQFLLELLSD SSNSSCITWE GTNGEFKMTD
360 370 380 390 400
PDEVARRWGE RKSKPNMNYD KLSRALRYYY DKNIMTKVHG KRYAYKFDFH
410 420 430 440 450
GIAQALQPHP PESSLYKYPS DLPYMGSYHA HPQKMNFVAP HPPALPVTSS
460 470 480
SFFAAPNPYW NSPTGGIYPN TRLPTSHMPS HLGTYY
Length:486
Mass (Da):54,608
Last modified:July 10, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA0B548DFAE25029E
GO
Isoform ERG-2 (identifier: P11308-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     232-255: Missing.

Show »
Length:462
Mass (Da):52,031
Checksum:iB29F14B0F5C2C697
GO
Isoform ERG-1 (identifier: P11308-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-99: Missing.
     232-255: Missing.

Show »
Length:363
Mass (Da):41,397
Checksum:iB77B652BEBAFDAFA
GO
Isoform 5 (identifier: P11308-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MIQTVPDPAAH → MAST

Show »
Length:479
Mass (Da):53,838
Checksum:iA5069C393E409483
GO
Isoform 7 (identifier: P11308-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     315-317: SGQ → WTQ
     318-486: Missing.

Show »
Length:317
Mass (Da):35,286
Checksum:iA30FAAD4E5E119CC
GO
Isoform 8 (identifier: P11308-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     256-325: DLPYEPPRRS...GQIQLWQFLL → GTKTPLCDLF...KTTLKELRAD
     326-486: Missing.

Show »
Length:325
Mass (Da):36,541
Checksum:iCF149350960CCE05
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B5MDW0B5MDW0_HUMAN
Erythroblast transformation-specifi...
ERG
455Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DG41A0A0C4DG41_HUMAN
Transcriptional regulator ERG
ERG
387Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8MZ24A8MZ24_HUMAN
Transcriptional regulator ERG
ERG
463Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8MX39A8MX39_HUMAN
Transcriptional regulator ERG
ERG
456Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A088AWP2A0A088AWP2_HUMAN
Transcriptional regulator ERG
ERG
220Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0014691 – 99Missing in isoform ERG-1. 2 PublicationsAdd BLAST99
Alternative sequenceiVSP_0265841 – 11MIQTVPDPAAH → MAST in isoform 5. 2 PublicationsAdd BLAST11
Alternative sequenceiVSP_026579232 – 255Missing in isoform ERG-1 and isoform ERG-2. 3 PublicationsAdd BLAST24
Alternative sequenceiVSP_026580256 – 325DLPYE…WQFLL → GTKTPLCDLFIERHPRCPAE IRALSHVIQRELIPELKPVP DSLILPLLIWRLNPLKPFHS KTTLKELRAD in isoform 8. CuratedAdd BLAST70
Alternative sequenceiVSP_026582315 – 317SGQ → WTQ in isoform 7. 1 Publication3
Alternative sequenceiVSP_026583318 – 486Missing in isoform 7. 1 PublicationAdd BLAST169
Alternative sequenceiVSP_026581326 – 486Missing in isoform 8. CuratedAdd BLAST161

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M17254 mRNA Translation: AAA52398.1
M21535 mRNA Translation: AAA35811.1
AY204741 mRNA Translation: AAP41719.1
AY204742 mRNA Translation: AAP41720.1
AK300395 mRNA Translation: BAG62127.1
AK303518 mRNA Translation: BAG64546.1
BC040168 mRNA Translation: AAH40168.1
S68130 mRNA Translation: AAB29724.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13657.1 [P11308-1]
CCDS13658.1 [P11308-4]
CCDS46648.1 [P11308-3]
CCDS58789.1 [P11308-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
A94294 TVHUEG

NCBI Reference Sequences

More...
RefSeqi
NP_001129626.1, NM_001136154.1 [P11308-3]
NP_001129627.1, NM_001136155.1
NP_001230357.1, NM_001243428.1 [P11308-3]
NP_001230358.1, NM_001243429.1 [P11308-2]
NP_001230361.1, NM_001243432.2 [P11308-5]
NP_001278320.1, NM_001291391.1 [P11308-6]
NP_004440.1, NM_004449.4 [P11308-1]
NP_891548.1, NM_182918.3 [P11308-4]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.473819

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000288319; ENSP00000288319; ENSG00000157554 [P11308-4]
ENST00000398897; ENSP00000381871; ENSG00000157554 [P11308-2]
ENST00000398911; ENSP00000381882; ENSG00000157554 [P11308-1]
ENST00000398919; ENSP00000381891; ENSG00000157554 [P11308-3]
ENST00000417133; ENSP00000414150; ENSG00000157554 [P11308-3]
ENST00000442448; ENSP00000394694; ENSG00000157554 [P11308-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
2078

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:2078

UCSC genome browser

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UCSCi
uc002yxa.4 human [P11308-3]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17254 mRNA Translation: AAA52398.1
M21535 mRNA Translation: AAA35811.1
AY204741 mRNA Translation: AAP41719.1
AY204742 mRNA Translation: AAP41720.1
AK300395 mRNA Translation: BAG62127.1
AK303518 mRNA Translation: BAG64546.1
BC040168 mRNA Translation: AAH40168.1
S68130 mRNA Translation: AAB29724.1
CCDSiCCDS13657.1 [P11308-1]
CCDS13658.1 [P11308-4]
CCDS46648.1 [P11308-3]
CCDS58789.1 [P11308-2]
PIRiA94294 TVHUEG
RefSeqiNP_001129626.1, NM_001136154.1 [P11308-3]
NP_001129627.1, NM_001136155.1
NP_001230357.1, NM_001243428.1 [P11308-3]
NP_001230358.1, NM_001243429.1 [P11308-2]
NP_001230361.1, NM_001243432.2 [P11308-5]
NP_001278320.1, NM_001291391.1 [P11308-6]
NP_004440.1, NM_004449.4 [P11308-1]
NP_891548.1, NM_182918.3 [P11308-4]
UniGeneiHs.473819

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SXENMR-A115-208[»]
4IRGX-ray1.70A313-412[»]
4IRHX-ray2.10A287-412[»]
4IRIX-ray2.77A287-412[»]
5YBCX-ray2.50A/C317-408[»]
5YBDX-ray2.77A/X317-406[»]
ProteinModelPortaliP11308
SMRiP11308
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108389, 94 interactors
CORUMiP11308
DIPiDIP-31028N
ELMiP11308
IntActiP11308, 17 interactors
MINTiP11308
STRINGi9606.ENSP00000381891

Chemistry databases

BindingDBiP11308
ChEMBLiCHEMBL1293191

PTM databases

iPTMnetiP11308
PhosphoSitePlusiP11308

Polymorphism and mutation databases

BioMutaiERG
DMDMi152031600

Proteomic databases

jPOSTiP11308
PaxDbiP11308
PeptideAtlasiP11308
PRIDEiP11308
ProteomicsDBi52735
52736 [P11308-1]
52737 [P11308-2]
52738 [P11308-4]
52739 [P11308-5]
52740 [P11308-6]
TopDownProteomicsiP11308-6 [P11308-6]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
2078
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000288319; ENSP00000288319; ENSG00000157554 [P11308-4]
ENST00000398897; ENSP00000381871; ENSG00000157554 [P11308-2]
ENST00000398911; ENSP00000381882; ENSG00000157554 [P11308-1]
ENST00000398919; ENSP00000381891; ENSG00000157554 [P11308-3]
ENST00000417133; ENSP00000414150; ENSG00000157554 [P11308-3]
ENST00000442448; ENSP00000394694; ENSG00000157554 [P11308-1]
GeneIDi2078
KEGGihsa:2078
UCSCiuc002yxa.4 human [P11308-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2078
DisGeNETi2078
EuPathDBiHostDB:ENSG00000157554.18

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ERG
HGNCiHGNC:3446 ERG
HPAiCAB018377
HPA046598
MalaCardsiERG
MIMi165080 gene
612219 phenotype
neXtProtiNX_P11308
OpenTargetsiENSG00000157554
Orphaneti319 Ewing sarcoma
370334 Extraskeletal Ewing sarcoma
PharmGKBiPA27858

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3806 Eukaryota
ENOG410Z0ZF LUCA
GeneTreeiENSGT00940000160662
HOVERGENiHBG001553
InParanoidiP11308
KOiK09435
OMAiEYGQTSK
OrthoDBi1568974at2759
PhylomeDBiP11308
TreeFamiTF350537

Enzyme and pathway databases

SignaLinkiP11308
SIGNORiP11308

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ERG human
EvolutionaryTraceiP11308

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ERG_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
2078

Protein Ontology

More...
PROi
PR:P11308

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000157554 Expressed in 197 organ(s), highest expression level in tendon of biceps brachii
CleanExiHS_ERG
ExpressionAtlasiP11308 baseline and differential
GenevisibleiP11308 HS

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000418 Ets_dom
IPR003118 Pointed_dom
IPR013761 SAM/pointed_sf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00178 Ets, 1 hit
PF02198 SAM_PNT, 1 hit
PRINTSiPR00454 ETSDOMAIN
SMARTiView protein in SMART
SM00413 ETS, 1 hit
SM00251 SAM_PNT, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF47769 SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS00345 ETS_DOMAIN_1, 1 hit
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit
PS51433 PNT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiERG_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P11308
Secondary accession number(s): B4DTW5
, B4E0T4, Q16113, Q6XXX4, Q6XXX5, Q8IXK9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 10, 2007
Last modified: January 16, 2019
This is version 199 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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