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Protein

Lysosome-associated membrane glycoprotein 1

Gene

LAMP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis.
Acts as a receptor for Lassa virus protein.1 Publication

GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • protein domain specific binding Source: Ensembl
  • virus receptor activity Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionHost cell receptor for virus entry, Receptor
Biological processHost-virus interaction

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Protein family/group databases

TCDBi9.A.16.1.1 the lysosomal protein import (lpi) family

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosome-associated membrane glycoprotein 1
Short name:
LAMP-1
Short name:
Lysosome-associated membrane protein 1
Alternative name(s):
CD107 antigen-like family member A
CD_antigen: CD107a
Gene namesi
Name:LAMP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000185896.10
HGNCiHGNC:6499 LAMP1
MIMi153330 gene
neXtProtiNX_P11279

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 382LumenalSequence analysisAdd BLAST354
Transmembranei383 – 405HelicalPROSITE-ProRule annotationAdd BLAST23
Topological domaini406 – 417CytoplasmicPROSITE-ProRule annotationAdd BLAST12

Keywords - Cellular componenti

Cell membrane, Endosome, Lysosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi76N → S: Complete loss of interaction with Lassa virus protein GPC. 1 Publication1

Organism-specific databases

DisGeNETi3916
OpenTargetsiENSG00000185896
PharmGKBiPA30283

Polymorphism and mutation databases

BioMutaiLAMP1
DMDMi206729915

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 282 PublicationsAdd BLAST28
ChainiPRO_000001710429 – 417Lysosome-associated membrane glycoprotein 1Add BLAST389

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi37N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi41 ↔ 80PROSITE-ProRule annotation1 Publication
Glycosylationi45N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi62N-linked (GlcNAc...) (polylactosaminoglycan) asparagine2 Publications1
Glycosylationi76N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi84N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi103N-linked (GlcNAc...) asparagine3 Publications1
Glycosylationi107N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi121N-linked (GlcNAc...) (polylactosaminoglycan) asparagine1 Publication1
Glycosylationi130N-linked (GlcNAc...) (polylactosaminoglycan) asparagine1 Publication1
Disulfide bondi155 ↔ 191PROSITE-ProRule annotation1 Publication
Glycosylationi165N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi181N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi197O-linked (GalNAc...) serine; partial1 Publication1
Glycosylationi199O-linked (GalNAc...) threonine1 Publication1
Glycosylationi200O-linked (GalNAc...) threonine1 Publication1
Glycosylationi207O-linked (GalNAc...) serine1 Publication1
Glycosylationi209O-linked (GalNAc...) serine1 Publication1
Glycosylationi211O-linked (GalNAc...) serine1 Publication1
Glycosylationi223N-linked (GlcNAc...) (polylactosaminoglycan) asparagine1 Publication1
Glycosylationi228N-linked (GlcNAc...) (polylactosaminoglycan) asparagine1 Publication1
Disulfide bondi231 ↔ 269PROSITE-ProRule annotation1 Publication
Glycosylationi241N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi249N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi261N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi293N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi322N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi338 ↔ 375PROSITE-ProRule annotation1 Publication

Post-translational modificationi

O- and N-glycosylated; some of the 18 N-linked glycans are polylactosaminoglycans. The glycosylation of N-76 is essential for Lassa virus entry into cells.5 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP11279
MaxQBiP11279
PaxDbiP11279
PeptideAtlasiP11279
PRIDEiP11279
ProteomicsDBi52734
TopDownProteomicsiP11279-1 [P11279-1]

PTM databases

GlyConnecti355
iPTMnetiP11279
PhosphoSitePlusiP11279
SwissPalmiP11279
UniCarbKBiP11279

Expressioni

Gene expression databases

BgeeiENSG00000185896 Expressed in 245 organ(s), highest expression level in nephron tubule
CleanExiHS_LAMP1
ExpressionAtlasiP11279 baseline and differential
GenevisibleiP11279 HS

Organism-specific databases

HPAiCAB004260
HPA014750

Interactioni

Subunit structurei

(Microbial infection) Interacts with Lassa virus protein glycoprotein.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110110, 43 interactors
DIPiDIP-44670N
ELMiP11279
IntActiP11279, 324 interactors
MINTiP11279
STRINGi9606.ENSP00000333298

Structurei

3D structure databases

ProteinModelPortaliP11279
SMRiP11279
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni29 – 194First lumenal domainAdd BLAST166
Regioni195 – 227HingeAdd BLAST33
Regioni228 – 382Second lumenal domainAdd BLAST155

Sequence similaritiesi

Belongs to the LAMP family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4818 Eukaryota
ENOG410XQ96 LUCA
GeneTreeiENSGT00530000063068
HOGENOMiHOG000230942
HOVERGENiHBG052303
InParanoidiP11279
KOiK06528
OMAiSKEETRC
OrthoDBiEOG091G09EV
PhylomeDBiP11279
TreeFamiTF316339

Family and domain databases

InterProiView protein in InterPro
IPR018134 LAMP_CS
IPR002000 Lysosome-assoc_membr_glycop
PANTHERiPTHR11506 PTHR11506, 1 hit
PfamiView protein in Pfam
PF01299 Lamp, 1 hit
PRINTSiPR00336 LYSASSOCTDMP
PROSITEiView protein in PROSITE
PS00310 LAMP_1, 2 hits
PS00311 LAMP_2, 1 hit
PS51407 LAMP_3, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P11279-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAPGSARRP LLLLLLLLLL GLMHCASAAM FMVKNGNGTA CIMANFSAAF
60 70 80 90 100
SVNYDTKSGP KNMTFDLPSD ATVVLNRSSC GKENTSDPSL VIAFGRGHTL
110 120 130 140 150
TLNFTRNATR YSVQLMSFVY NLSDTHLFPN ASSKEIKTVE SITDIRADID
160 170 180 190 200
KKYRCVSGTQ VHMNNVTVTL HDATIQAYLS NSSFSRGETR CEQDRPSPTT
210 220 230 240 250
APPAPPSPSP SPVPKSPSVD KYNVSGTNGT CLLASMGLQL NLTYERKDNT
260 270 280 290 300
TVTRLLNINP NKTSASGSCG AHLVTLELHS EGTTVLLFQF GMNASSSRFF
310 320 330 340 350
LQGIQLNTIL PDARDPAFKA ANGSLRALQA TVGNSYKCNA EEHVRVTKAF
360 370 380 390 400
SVNIFKVWVQ AFKVEGGQFG SVEECLLDEN SMLIPIAVGG ALAGLVLIVL
410
IAYLVGRKRS HAGYQTI
Length:417
Mass (Da):44,882
Last modified:September 23, 2008 - v3
Checksum:i3E0A285744DD6588
GO
Isoform 2 (identifier: P11279-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     135-187: Missing.

Note: No experimental confirmation available.
Show »
Length:364
Mass (Da):38,986
Checksum:iD61B19312DC62CF1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2A → M in AAA60382 (PubMed:3198605).Curated1
Sequence conflicti5G → R in AAA60382 (PubMed:3198605).Curated1
Sequence conflicti16 – 26LLLLLGLMHCA → PVAAARPHALS in AAA60382 (PubMed:3198605).CuratedAdd BLAST11
Sequence conflicti33 – 40VKNGNGTA → MARGGRVR in AAA59524 (PubMed:3131762).Curated8
Sequence conflicti262K → T in AAF66141 (PubMed:8517882).Curated1
Sequence conflicti377Missing in AAF66141 (PubMed:8517882).Curated1
Sequence conflicti382M → T in AAA60382 (PubMed:3198605).Curated1
Sequence conflicti382M → T in AAA59524 (PubMed:3131762).Curated1
Sequence conflicti382M → T in AAF66141 (PubMed:8517882).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_046450309I → T. Corresponds to variant dbSNP:rs9577230Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056032135 – 187Missing in isoform 2. 1 PublicationAdd BLAST53

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04182 mRNA Translation: AAA60382.1
AK301584 mRNA Translation: BAG63075.1
AL136221 Genomic DNA No translation available.
CH471085 Genomic DNA Translation: EAX09202.1
BC006345 mRNA Translation: AAH06345.2
BC007845 mRNA Translation: AAH07845.2
BC021288 mRNA Translation: AAH21288.1
BC093044 mRNA Translation: AAH93044.1
J03263 mRNA Translation: AAA59524.1
AH003113 Genomic DNA Translation: AAF66141.1
CCDSiCCDS41909.1 [P11279-1]
PIRiA31959
RefSeqiNP_005552.3, NM_005561.3 [P11279-1]
UniGeneiHs.494419

Genome annotation databases

EnsembliENST00000332556; ENSP00000333298; ENSG00000185896 [P11279-1]
GeneIDi3916
KEGGihsa:3916
UCSCiuc001vtm.2 human [P11279-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04182 mRNA Translation: AAA60382.1
AK301584 mRNA Translation: BAG63075.1
AL136221 Genomic DNA No translation available.
CH471085 Genomic DNA Translation: EAX09202.1
BC006345 mRNA Translation: AAH06345.2
BC007845 mRNA Translation: AAH07845.2
BC021288 mRNA Translation: AAH21288.1
BC093044 mRNA Translation: AAH93044.1
J03263 mRNA Translation: AAA59524.1
AH003113 Genomic DNA Translation: AAF66141.1
CCDSiCCDS41909.1 [P11279-1]
PIRiA31959
RefSeqiNP_005552.3, NM_005561.3 [P11279-1]
UniGeneiHs.494419

3D structure databases

ProteinModelPortaliP11279
SMRiP11279
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110110, 43 interactors
DIPiDIP-44670N
ELMiP11279
IntActiP11279, 324 interactors
MINTiP11279
STRINGi9606.ENSP00000333298

Protein family/group databases

TCDBi9.A.16.1.1 the lysosomal protein import (lpi) family

PTM databases

GlyConnecti355
iPTMnetiP11279
PhosphoSitePlusiP11279
SwissPalmiP11279
UniCarbKBiP11279

Polymorphism and mutation databases

BioMutaiLAMP1
DMDMi206729915

Proteomic databases

EPDiP11279
MaxQBiP11279
PaxDbiP11279
PeptideAtlasiP11279
PRIDEiP11279
ProteomicsDBi52734
TopDownProteomicsiP11279-1 [P11279-1]

Protocols and materials databases

DNASUi3916
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332556; ENSP00000333298; ENSG00000185896 [P11279-1]
GeneIDi3916
KEGGihsa:3916
UCSCiuc001vtm.2 human [P11279-1]

Organism-specific databases

CTDi3916
DisGeNETi3916
EuPathDBiHostDB:ENSG00000185896.10
GeneCardsiLAMP1
H-InvDBiHIX0030831
HGNCiHGNC:6499 LAMP1
HPAiCAB004260
HPA014750
MIMi153330 gene
neXtProtiNX_P11279
OpenTargetsiENSG00000185896
PharmGKBiPA30283
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4818 Eukaryota
ENOG410XQ96 LUCA
GeneTreeiENSGT00530000063068
HOGENOMiHOG000230942
HOVERGENiHBG052303
InParanoidiP11279
KOiK06528
OMAiSKEETRC
OrthoDBiEOG091G09EV
PhylomeDBiP11279
TreeFamiTF316339

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSiLAMP1 human
GeneWikiiLAMP1
GenomeRNAii3916
PROiPR:P11279
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000185896 Expressed in 245 organ(s), highest expression level in nephron tubule
CleanExiHS_LAMP1
ExpressionAtlasiP11279 baseline and differential
GenevisibleiP11279 HS

Family and domain databases

InterProiView protein in InterPro
IPR018134 LAMP_CS
IPR002000 Lysosome-assoc_membr_glycop
PANTHERiPTHR11506 PTHR11506, 1 hit
PfamiView protein in Pfam
PF01299 Lamp, 1 hit
PRINTSiPR00336 LYSASSOCTDMP
PROSITEiView protein in PROSITE
PS00310 LAMP_1, 2 hits
PS00311 LAMP_2, 1 hit
PS51407 LAMP_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLAMP1_HUMAN
AccessioniPrimary (citable) accession number: P11279
Secondary accession number(s): B4DWL3
, Q8WU33, Q96I40, Q9BRD2, Q9NP13
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: September 23, 2008
Last modified: November 7, 2018
This is version 182 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  6. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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Main funding by: National Institutes of Health

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