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UniProtKB - P11279 (LAMP1_HUMAN)

Entry version 205 (23 Feb 2022)
Sequence version 3 (23 Sep 2008)
Previous versions | rss
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Protein

Lysosome-associated membrane glycoprotein 1

Gene

LAMP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, autophagy, and cholesterol homeostasis (By similarity).

Plays also an important role in NK-cells cytotoxicity (PubMed:23632890, PubMed:2022921).

Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule (PubMed:23632890).

In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content (PubMed:23847195).

Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis.

By similarity3 Publications

(Microbial infection) Acts as a receptor for Lassa virus glycoprotein (PubMed:24970085).

Promotes also fusion of the virus with host membrane in less acidic endosomes (PubMed:29295909).

2 Publications

(Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHost cell receptor for virus entry, Receptor
Biological processHost-virus interaction

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P11279

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6798695, Neutrophil degranulation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P11279

Protein family/group databases

Transport Classification Database

More...TCDBi		9.A.16.1.1, the lysosomal protein import (lpi) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lysosome-associated membrane glycoprotein 1Curated
Short name:
LAMP-1
Short name:
Lysosome-associated membrane protein 1
Alternative name(s):
CD107 antigen-like family member A
CD_antigen: CD107a
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LAMP1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6499, LAMP1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		153330, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P11279

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000185896

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini29 – 382LumenalSequence analysisAdd BLAST354
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei383 – 405HelicalPROSITE-ProRule annotationAdd BLAST23
Topological domaini406 – 417CytoplasmicPROSITE-ProRule annotationAdd BLAST12

Keywords - Cellular componenti

Cell membrane, Endosome, Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi76N → S: Complete loss of interaction with Lassa virus protein GPC. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		3916

Open Targets

More...OpenTargetsi		ENSG00000185896

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30283

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P11279, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		LAMP1

Domain mapping of disease mutations (DMDM)

More...DMDMi		206729915

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 282 PublicationsAdd BLAST28
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001710429 – 417Lysosome-associated membrane glycoprotein 1Add BLAST389

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi37N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi41 ↔ 80PROSITE-ProRule annotation1 Publication
Glycosylationi45N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi62N-linked (GlcNAc...) (polylactosaminoglycan) asparagine2 Publications1
Glycosylationi76N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi84N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi103N-linked (GlcNAc...) asparagine3 Publications1
Glycosylationi107N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi121N-linked (GlcNAc...) (polylactosaminoglycan) asparagine1 Publication1
Glycosylationi130N-linked (GlcNAc...) (polylactosaminoglycan) asparagine1 Publication1
Disulfide bondi155 ↔ 191PROSITE-ProRule annotation1 Publication
Glycosylationi165N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi181N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi197O-linked (GalNAc...) serine; partial1 Publication1
Glycosylationi199O-linked (GalNAc...) threonine1 Publication1
Glycosylationi200O-linked (GalNAc...) threonine1 Publication1
Glycosylationi207O-linked (GalNAc...) serine1 Publication1
Glycosylationi209O-linked (GalNAc...) serine1 Publication1
Glycosylationi211O-linked (GalNAc...) serine1 Publication1
Glycosylationi223N-linked (GlcNAc...) (polylactosaminoglycan) asparagine1 Publication1
Glycosylationi228N-linked (GlcNAc...) (polylactosaminoglycan) asparagine1 Publication1
Disulfide bondi231 ↔ 269PROSITE-ProRule annotation1 Publication
Glycosylationi241N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi249N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi261N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi293N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi322N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi338 ↔ 375PROSITE-ProRule annotation1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

O- and N-glycosylated; some of the 18 N-linked glycans are polylactosaminoglycans. The glycosylation of N-76 is essential for Lassa virus entry into cells.5 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P11279

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P11279

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P11279

MaxQB - The MaxQuant DataBase

More...MaxQBi		P11279

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P11279

PeptideAtlas

More...PeptideAtlasi		P11279

PRoteomics IDEntifications database

More...PRIDEi		P11279

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		52734 [P11279-1]
5353

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P11279-1 [P11279-1]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		355, 114 N-Linked glycans (10 sites), 3 O-Linked glycans

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P11279, 29 sites, 166 N-linked glycans (10 sites), 11 O-linked glycans (7 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P11279

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P11279

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P11279

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000185896, Expressed in nephron tubule and 258 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P11279, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P11279, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000185896, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

(Microbial infection) Interacts with Lassa virus protein glycoprotein.

1 Publication

(Microbial infection) Interacts with mumps virus protein F; this interaction promotes protein F cleavage by FURIN.

1 Publication

Interacts with ABCB9; this interaction strongly stabilizes ABCB9 and protects ABCB9 against lysosomal degradation (PubMed:22641697).

Interacts with FURIN (PubMed:32295904).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110110, 553 interactors

Database of interacting proteins

More...DIPi		DIP-44670N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		P11279

Protein interaction database and analysis system

More...IntActi		P11279, 345 interactors

Molecular INTeraction database

More...MINTi		P11279

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000333298

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P11279, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P11279

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni29 – 194First lumenal domainAdd BLAST166
Regioni184 – 221DisorderedSequence analysisAdd BLAST38
Regioni195 – 227HingeAdd BLAST33
Regioni228 – 382Second lumenal domainAdd BLAST155

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi198 – 215Pro residuesSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LAMP family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4818, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182899

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_055379_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P11279

Identification of Orthologs from Complete Genome Data

More...OMAi		ETRCKQD

Database of Orthologous Groups

More...OrthoDBi		993446at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P11279

TreeFam database of animal gene trees

More...TreeFami		TF316339

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR018134, LAMP_CS
IPR002000, Lysosome-assoc_membr_glycop

The PANTHER Classification System

More...PANTHERi		PTHR11506, PTHR11506, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01299, Lamp, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00336, LYSASSOCTDMP

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00310, LAMP_1, 2 hits
PS00311, LAMP_2, 1 hit
PS51407, LAMP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P11279-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAPGSARRP LLLLLLLLLL GLMHCASAAM FMVKNGNGTA CIMANFSAAF 
        60         70         80         90        100
SVNYDTKSGP KNMTFDLPSD ATVVLNRSSC GKENTSDPSL VIAFGRGHTL 
       110        120        130        140        150
TLNFTRNATR YSVQLMSFVY NLSDTHLFPN ASSKEIKTVE SITDIRADID 
       160        170        180        190        200
KKYRCVSGTQ VHMNNVTVTL HDATIQAYLS NSSFSRGETR CEQDRPSPTT 
       210        220        230        240        250
APPAPPSPSP SPVPKSPSVD KYNVSGTNGT CLLASMGLQL NLTYERKDNT 
       260        270        280        290        300
TVTRLLNINP NKTSASGSCG AHLVTLELHS EGTTVLLFQF GMNASSSRFF 
       310        320        330        340        350
LQGIQLNTIL PDARDPAFKA ANGSLRALQA TVGNSYKCNA EEHVRVTKAF 
       360        370        380        390        400
SVNIFKVWVQ AFKVEGGQFG SVEECLLDEN SMLIPIAVGG ALAGLVLIVL 
       410 
IAYLVGRKRS HAGYQTI
Length:417
Mass (Da):44,882
Last modified:September 23, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3E0A285744DD6588
GO
Isoform 2 (identifier: P11279-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     135-187: Missing.

Show »
Length:364
Mass (Da):38,986
Checksum:iD61B19312DC62CF1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2A → M in AAA60382 (PubMed:3198605).Curated1
Sequence conflicti5G → R in AAA60382 (PubMed:3198605).Curated1
Sequence conflicti16 – 26LLLLLGLMHCA → PVAAARPHALS in AAA60382 (PubMed:3198605).CuratedAdd BLAST11
Sequence conflicti33 – 40VKNGNGTA → MARGGRVR in AAA59524 (PubMed:3131762).Curated8
Sequence conflicti262K → T in AAF66141 (PubMed:8517882).Curated1
Sequence conflicti377Missing in AAF66141 (PubMed:8517882).Curated1
Sequence conflicti382M → T in AAA60382 (PubMed:3198605).Curated1
Sequence conflicti382M → T in AAA59524 (PubMed:3131762).Curated1
Sequence conflicti382M → T in AAF66141 (PubMed:8517882).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_046450309I → T. Corresponds to variant dbSNP:rs9577230Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_056032135 – 187Missing in isoform 2. 1 PublicationAdd BLAST53

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
J04182 mRNA Translation: AAA60382.1
AK301584 mRNA Translation: BAG63075.1
AL136221 Genomic DNA No translation available.
CH471085 Genomic DNA Translation: EAX09202.1
BC006345 mRNA Translation: AAH06345.2
BC007845 mRNA Translation: AAH07845.2
BC021288 mRNA Translation: AAH21288.1
BC093044 mRNA Translation: AAH93044.1
J03263 mRNA Translation: AAA59524.1
AH003113 Genomic DNA Translation: AAF66141.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS41909.1 [P11279-1]

Protein sequence database of the Protein Information Resource

More...PIRi		A31959

NCBI Reference Sequences

More...RefSeqi		NP_005552.3, NM_005561.3 [P11279-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000332556; ENSP00000333298; ENSG00000185896

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3916

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3916

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000332556.5; ENSP00000333298.4; NM_005561.4; NP_005552.3

UCSC genome browser

More...UCSCi		uc001vtm.2, human [P11279-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04182 mRNA Translation: AAA60382.1
AK301584 mRNA Translation: BAG63075.1
AL136221 Genomic DNA No translation available.
CH471085 Genomic DNA Translation: EAX09202.1
BC006345 mRNA Translation: AAH06345.2
BC007845 mRNA Translation: AAH07845.2
BC021288 mRNA Translation: AAH21288.1
BC093044 mRNA Translation: AAH93044.1
J03263 mRNA Translation: AAA59524.1
AH003113 Genomic DNA Translation: AAF66141.1
CCDSiCCDS41909.1 [P11279-1]
PIRiA31959
RefSeqiNP_005552.3, NM_005561.3 [P11279-1]

3D structure databases

SMRiP11279
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi110110, 553 interactors
DIPiDIP-44670N
ELMiP11279
IntActiP11279, 345 interactors
MINTiP11279
STRINGi9606.ENSP00000333298

Protein family/group databases

TCDBi9.A.16.1.1, the lysosomal protein import (lpi) family

PTM databases

GlyConnecti355, 114 N-Linked glycans (10 sites), 3 O-Linked glycans
GlyGeniP11279, 29 sites, 166 N-linked glycans (10 sites), 11 O-linked glycans (7 sites)
iPTMnetiP11279
PhosphoSitePlusiP11279
SwissPalmiP11279

Genetic variation databases

BioMutaiLAMP1
DMDMi206729915

Proteomic databases

EPDiP11279
jPOSTiP11279
MassIVEiP11279
MaxQBiP11279
PaxDbiP11279
PeptideAtlasiP11279
PRIDEiP11279
ProteomicsDBi52734 [P11279-1]
5353
TopDownProteomicsiP11279-1 [P11279-1]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P11279, 10 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2703, 1407 antibodies from 51 providers

The DNASU plasmid repository

More...DNASUi		3916

Genome annotation databases

EnsembliENST00000332556; ENSP00000333298; ENSG00000185896
GeneIDi3916
KEGGihsa:3916
MANE-SelectiENST00000332556.5; ENSP00000333298.4; NM_005561.4; NP_005552.3
UCSCiuc001vtm.2, human [P11279-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3916
DisGeNETi3916

GeneCards: human genes, protein and diseases

More...GeneCardsi		LAMP1
HGNCiHGNC:6499, LAMP1
HPAiENSG00000185896, Low tissue specificity
MIMi153330, gene
neXtProtiNX_P11279
OpenTargetsiENSG00000185896
PharmGKBiPA30283
VEuPathDBiHostDB:ENSG00000185896

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4818, Eukaryota
GeneTreeiENSGT00950000182899
HOGENOMiCLU_055379_2_0_1
InParanoidiP11279
OMAiETRCKQD
OrthoDBi993446at2759
PhylomeDBiP11279
TreeFamiTF316339

Enzyme and pathway databases

PathwayCommonsiP11279
ReactomeiR-HSA-6798695, Neutrophil degranulation
SignaLinkiP11279

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3916, 9 hits in 1047 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		LAMP1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		LAMP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3916
PharosiP11279, Tbio

Protein Ontology

More...PROi		PR:P11279
RNActiP11279, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000185896, Expressed in nephron tubule and 258 other tissues
ExpressionAtlasiP11279, baseline and differential
GenevisibleiP11279, HS

Family and domain databases

InterProiView protein in InterPro
IPR018134, LAMP_CS
IPR002000, Lysosome-assoc_membr_glycop
PANTHERiPTHR11506, PTHR11506, 1 hit
PfamiView protein in Pfam
PF01299, Lamp, 1 hit
PRINTSiPR00336, LYSASSOCTDMP
PROSITEiView protein in PROSITE
PS00310, LAMP_1, 2 hits
PS00311, LAMP_2, 1 hit
PS51407, LAMP_3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLAMP1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P11279
Secondary accession number(s): B4DWL3
, Q8WU33, Q96I40, Q9BRD2, Q9NP13
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: September 23, 2008
Last modified: February 23, 2022
This is version 205 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families
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