LAMP1

Functionⁱ

Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis.

Acts as a receptor for Lassa virus protein.1 Publication

GO - Molecular functionⁱ

enzyme binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 22641697
protein domain specific binding Source: Ensembl
virus receptor activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

autophagic cell death Source: Ensembl
establishment of protein localization to organelle
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23632890
Golgi to lysosome transport
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23632890
granzyme-mediated apoptotic signaling pathway
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23632890
neutrophil degranulation Source: Reactome
positive regulation of natural killer cell degranulation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23632890
positive regulation of natural killer cell mediated cytotoxicity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23632890
protein stabilization Source: UniProtKB
regulation of organelle transport along microtubule
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23632890

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Host cell receptor for virus entry, Receptor
Biological process	Host-virus interaction

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6798695 Neutrophil degranulation

Reactomeⁱ

R-HSA-6798695 Neutrophil degranulation

Protein family/group databases

TCDBⁱ	9.A.16.1.1 the lysosomal protein import (lpi) family

TCDBⁱ

9.A.16.1.1 the lysosomal protein import (lpi) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Lysosome-associated membrane glycoprotein 1 Short name: LAMP-1 Short name: Lysosome-associated membrane protein 1 Alternative name(s): CD107 antigen-like family member A CD_antigen: CD107a
Gene namesⁱ	Name:LAMP1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 13

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000185896.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6499 LAMP1
MIMⁱ	153330 gene
neXtProtⁱ	NX_P11279

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	29 – 382	LumenalSequence analysisAdd BLAST	354
Transmembraneⁱ	383 – 405	HelicalPROSITE-ProRule annotationAdd BLAST	23
Topological domainⁱ	406 – 417	CytoplasmicPROSITE-ProRule annotationAdd BLAST	12

Keywords - Cellular componentⁱ

Cell membrane, Endosome, Lysosome, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	76	N → S: Complete loss of interaction with Lassa virus protein GPC. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3916
Open Targets More...OpenTargetsⁱ	ENSG00000185896
PharmGKBⁱ	PA30283

Polymorphism and mutation databases

BioMutaⁱ	LAMP1
DMDMⁱ	206729915

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 28	2 PublicationsAdd BLAST		28
ChainⁱPRO_0000017104	29 – 417	Lysosome-associated membrane glycoprotein 1Add BLAST		389

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	37	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	41 ↔ 80	PROSITE-ProRule annotation1 Publication
Glycosylationⁱ	45	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	62	N-linked (GlcNAc...) (polylactosaminoglycan) asparagine2 Publications	1
Glycosylationⁱ	76	N-linked (GlcNAc...) asparagine2 Publications	1
Glycosylationⁱ	84	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	103	N-linked (GlcNAc...) asparagine3 Publications	1
Glycosylationⁱ	107	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	121	N-linked (GlcNAc...) (polylactosaminoglycan) asparagine1 Publication	1
Glycosylationⁱ	130	N-linked (GlcNAc...) (polylactosaminoglycan) asparagine1 Publication	1
Disulfide bondⁱ	155 ↔ 191	PROSITE-ProRule annotation1 Publication
Glycosylationⁱ	165	N-linked (GlcNAc...) asparagine2 Publications	1
Glycosylationⁱ	181	N-linked (GlcNAc...) asparagine2 Publications	1
Glycosylationⁱ	197	O-linked (GalNAc...) serine; partial1 Publication	1
Glycosylationⁱ	199	O-linked (GalNAc...) threonine1 Publication	1
Glycosylationⁱ	200	O-linked (GalNAc...) threonine1 Publication	1
Glycosylationⁱ	207	O-linked (GalNAc...) serine1 Publication	1
Glycosylationⁱ	209	O-linked (GalNAc...) serine1 Publication	1
Glycosylationⁱ	211	O-linked (GalNAc...) serine1 Publication	1
Glycosylationⁱ	223	N-linked (GlcNAc...) (polylactosaminoglycan) asparagine1 Publication	1
Glycosylationⁱ	228	N-linked (GlcNAc...) (polylactosaminoglycan) asparagine1 Publication	1
Disulfide bondⁱ	231 ↔ 269	PROSITE-ProRule annotation1 Publication
Glycosylationⁱ	241	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	249	N-linked (GlcNAc...) asparagine2 Publications	1
Glycosylationⁱ	261	N-linked (GlcNAc...) asparagine2 Publications	1
Glycosylationⁱ	293	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	322	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	338 ↔ 375	PROSITE-ProRule annotation1 Publication

Post-translational modificationⁱ

O- and N-glycosylated; some of the 18 N-linked glycans are polylactosaminoglycans. The glycosylation of N-76 is essential for Lassa virus entry into cells.5 Publications

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

EPDⁱ	P11279
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P11279
PaxDbⁱ	P11279
PeptideAtlas More...PeptideAtlasⁱ	P11279
PRIDEⁱ	P11279
ProteomicsDBⁱ	52734
TopDownProteomicsⁱ	P11279-1 [P11279-1]

PTM databases

GlyConnectⁱ	355
iPTMnetⁱ	P11279
PhosphoSitePlusⁱ	P11279
SwissPalmⁱ	P11279
UniCarbKBⁱ	P11279

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000185896 Expressed in 245 organ(s), highest expression level in nephron tubule
CleanExⁱ	HS_LAMP1
ExpressionAtlasⁱ	P11279 baseline and differential
Genevisibleⁱ	P11279 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB004260 HPA014750

HPAⁱ

CAB004260
HPA014750

Interactionⁱ

Subunit structureⁱ

(Microbial infection) Interacts with Lassa virus protein glycoprotein.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
GPC	P08669	4	EBI-2805407,EBI-8411266	From Lassa virus (strain Mouse/Sierra Leone/Josiah/1976).
RRAGB	Q5VZM2	2	EBI-2805407,EBI-993049

GO - Molecular functionⁱ

enzyme binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 22641697
protein domain specific binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	110110, 43 interactors
Database of interacting proteins More...DIPⁱ	DIP-44670N
ELMⁱ	P11279
IntActⁱ	P11279, 324 interactors
Molecular INTeraction database More...MINTⁱ	P11279
STRINGⁱ	9606.ENSP00000333298

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P11279
SMRⁱ	P11279
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	29 – 194	First lumenal domainAdd BLAST	166
Regionⁱ	195 – 227	HingeAdd BLAST	33
Regionⁱ	228 – 382	Second lumenal domainAdd BLAST	155

Sequence similaritiesⁱ

Belongs to the LAMP family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG4818 Eukaryota ENOG410XQ96 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063068
HOGENOMⁱ	HOG000230942
HOVERGENⁱ	HBG052303
InParanoidⁱ	P11279
KEGG Orthology (KO) More...KOⁱ	K06528
OMAⁱ	SKEETRC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09EV
PhylomeDBⁱ	P11279
TreeFamⁱ	TF316339

Family and domain databases

InterProⁱ	View protein in InterPro IPR018134 LAMP_CS IPR002000 Lysosome-assoc_membr_glycop
PANTHERⁱ	PTHR11506 PTHR11506, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01299 Lamp, 1 hit
PRINTSⁱ	PR00336 LYSASSOCTDMP
PROSITEⁱ	View protein in PROSITE PS00310 LAMP_1, 2 hits PS00311 LAMP_2, 1 hit PS51407 LAMP_3, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: P11279-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPGSARRP LLLLLLLLLL GLMHCASAAM FMVKNGNGTA CIMANFSAAF 
        60         70         80         90        100
SVNYDTKSGP KNMTFDLPSD ATVVLNRSSC GKENTSDPSL VIAFGRGHTL 
       110        120        130        140        150
TLNFTRNATR YSVQLMSFVY NLSDTHLFPN ASSKEIKTVE SITDIRADID 
       160        170        180        190        200
KKYRCVSGTQ VHMNNVTVTL HDATIQAYLS NSSFSRGETR CEQDRPSPTT 
       210        220        230        240        250
APPAPPSPSP SPVPKSPSVD KYNVSGTNGT CLLASMGLQL NLTYERKDNT 
       260        270        280        290        300
TVTRLLNINP NKTSASGSCG AHLVTLELHS EGTTVLLFQF GMNASSSRFF 
       310        320        330        340        350
LQGIQLNTIL PDARDPAFKA ANGSLRALQA TVGNSYKCNA EEHVRVTKAF 
       360        370        380        390        400
SVNIFKVWVQ AFKVEGGQFG SVEECLLDEN SMLIPIAVGG ALAGLVLIVL 
       410 
IAYLVGRKRS HAGYQTI

Length:417

Mass (Da):44,882

Last modified:September 23, 2008 - v3

Checksum:ⁱ3E0A285744DD6588

GO

Isoform 2 (identifier: P11279-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
135-187: Missing.

« Hide

        10         20         30         40         50
MAAPGSARRP LLLLLLLLLL GLMHCASAAM FMVKNGNGTA CIMANFSAAF 
        60         70         80         90        100
SVNYDTKSGP KNMTFDLPSD ATVVLNRSSC GKENTSDPSL VIAFGRGHTL 
       110        120        130        140        150
TLNFTRNATR YSVQLMSFVY NLSDTHLFPN ASSKETRCEQ DRPSPTTAPP 
       160        170        180        190        200
APPSPSPSPV PKSPSVDKYN VSGTNGTCLL ASMGLQLNLT YERKDNTTVT 
       210        220        230        240        250
RLLNINPNKT SASGSCGAHL VTLELHSEGT TVLLFQFGMN ASSSRFFLQG 
       260        270        280        290        300
IQLNTILPDA RDPAFKAANG SLRALQATVG NSYKCNAEEH VRVTKAFSVN 
       310        320        330        340        350
IFKVWVQAFK VEGGQFGSVE ECLLDENSML IPIAVGGALA GLVLIVLIAY 
       360 
LVGRKRSHAG YQTI

Note: No experimental confirmation available.

Show »

Length:364

Mass (Da):38,986

Checksum:ⁱD61B19312DC62CF1

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	2	A → M in AAA60382 (PubMed:3198605).Curated	1
Sequence conflictⁱ	5	G → R in AAA60382 (PubMed:3198605).Curated	1
Sequence conflictⁱ	16 – 26	LLLLLGLMHCA → PVAAARPHALS in AAA60382 (PubMed:3198605).CuratedAdd BLAST	11
Sequence conflictⁱ	33 – 40	VKNGNGTA → MARGGRVR in AAA59524 (PubMed:3131762).Curated	8
Sequence conflictⁱ	262	K → T in AAF66141 (PubMed:8517882).Curated	1
Sequence conflictⁱ	377	Missing in AAF66141 (PubMed:8517882).Curated	1
Sequence conflictⁱ	382	M → T in AAA60382 (PubMed:3198605).Curated	1
Sequence conflictⁱ	382	M → T in AAA59524 (PubMed:3131762).Curated	1
Sequence conflictⁱ	382	M → T in AAF66141 (PubMed:8517882).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_046450	309	I → T. Corresponds to variant dbSNP:rs9577230Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056032	135 – 187	Missing in isoform 2. 1 PublicationAdd BLAST		53

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J04182 mRNA Translation: AAA60382.1 AK301584 mRNA Translation: BAG63075.1 AL136221 Genomic DNA No translation available. CH471085 Genomic DNA Translation: EAX09202.1 BC006345 mRNA Translation: AAH06345.2 BC007845 mRNA Translation: AAH07845.2 BC021288 mRNA Translation: AAH21288.1 BC093044 mRNA Translation: AAH93044.1 J03263 mRNA Translation: AAA59524.1 AH003113 Genomic DNA Translation: AAF66141.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS41909.1 [P11279-1]
PIRⁱ	A31959
NCBI Reference Sequences More...RefSeqⁱ	NP_005552.3, NM_005561.3 [P11279-1]
UniGeneⁱ	Hs.494419

Genome annotation databases

Ensemblⁱ	ENST00000332556; ENSP00000333298; ENSG00000185896 [P11279-1]
GeneIDⁱ	3916
KEGGⁱ	hsa:3916
UCSC genome browser More...UCSCⁱ	uc001vtm.2 human [P11279-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P11279	Lysosomal-associated membrane protein 1, isoform CRA_a		HUMAN		417	UniRef100_P11279
cDNA FLJ35079 fis, clone PLACE6005283, highly similar to Lysosome-associated membrane glycoprotein 1		HUMAN		395

Protein	Similar proteins		Species	Score	Length	Source
P11279	Lysosomal-associated membrane protein 1, isoform CRA_a		HUMAN		417	UniRef90_P11279
Lysosomal-associated membrane protein 1		PANTR		481
Uncharacterized protein		PANPA		465
Lysosomal associated membrane protein 1		GORGO		465
Uncharacterized protein		MACMU		463
+44

Protein	Similar proteins		Species	Score	Length	Source
P11279	Lysosome-associated membrane glycoprotein 1		CRIGR		407	UniRef50_P11279
Lysosome-associated membrane glycoprotein 1	)	MOUSE		406
Lysosome-associated membrane glycoprotein 1		RAT		407
Lysosome-associated membrane glycoprotein 1		BOVIN		409
Lysosomal-associated membrane protein 1, isoform CRA_a		HUMAN		417
+170
P11279-2	lysosome-associated membrane glycoprotein 1		DIPOR		406	UniRef50_P11279-2
UPI00020E408A		PANTR		364
UPI000DC16E09		THEGE		363

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J04182 mRNA Translation: AAA60382.1 AK301584 mRNA Translation: BAG63075.1 AL136221 Genomic DNA No translation available. CH471085 Genomic DNA Translation: EAX09202.1 BC006345 mRNA Translation: AAH06345.2 BC007845 mRNA Translation: AAH07845.2 BC021288 mRNA Translation: AAH21288.1 BC093044 mRNA Translation: AAH93044.1 J03263 mRNA Translation: AAA59524.1 AH003113 Genomic DNA Translation: AAF66141.1
CCDSⁱ	CCDS41909.1 [P11279-1]
PIRⁱ	A31959
RefSeqⁱ	NP_005552.3, NM_005561.3 [P11279-1]
UniGeneⁱ	Hs.494419

3D structure databases

ProteinModelPortalⁱ	P11279
SMRⁱ	P11279
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110110, 43 interactors
DIPⁱ	DIP-44670N
ELMⁱ	P11279
IntActⁱ	P11279, 324 interactors
MINTⁱ	P11279
STRINGⁱ	9606.ENSP00000333298

Protein family/group databases

TCDBⁱ	9.A.16.1.1 the lysosomal protein import (lpi) family

TCDBⁱ

9.A.16.1.1 the lysosomal protein import (lpi) family

PTM databases

GlyConnectⁱ	355
iPTMnetⁱ	P11279
PhosphoSitePlusⁱ	P11279
SwissPalmⁱ	P11279
UniCarbKBⁱ	P11279

Polymorphism and mutation databases

BioMutaⁱ	LAMP1
DMDMⁱ	206729915

Proteomic databases

EPDⁱ	P11279
MaxQBⁱ	P11279
PaxDbⁱ	P11279
PeptideAtlasⁱ	P11279
PRIDEⁱ	P11279
ProteomicsDBⁱ	52734
TopDownProteomicsⁱ	P11279-1 [P11279-1]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3916
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000332556; ENSP00000333298; ENSG00000185896 [P11279-1]
GeneIDⁱ	3916
KEGGⁱ	hsa:3916
UCSCⁱ	uc001vtm.2 human [P11279-1]

Organism-specific databases

CTDⁱ	3916
DisGeNETⁱ	3916
EuPathDBⁱ	HostDB:ENSG00000185896.10
GeneCardsⁱ	LAMP1
H-InvDBⁱ	HIX0030831
HGNCⁱ	HGNC:6499 LAMP1
HPAⁱ	CAB004260 HPA014750
MIMⁱ	153330 gene
neXtProtⁱ	NX_P11279
OpenTargetsⁱ	ENSG00000185896
PharmGKBⁱ	PA30283
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4818 Eukaryota ENOG410XQ96 LUCA
GeneTreeⁱ	ENSGT00530000063068
HOGENOMⁱ	HOG000230942
HOVERGENⁱ	HBG052303
InParanoidⁱ	P11279
KOⁱ	K06528
OMAⁱ	SKEETRC
OrthoDBⁱ	EOG091G09EV
PhylomeDBⁱ	P11279
TreeFamⁱ	TF316339

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6798695 Neutrophil degranulation

Reactomeⁱ

R-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSⁱ	LAMP1 human
GeneWikiⁱ	LAMP1
GenomeRNAiⁱ	3916
Protein Ontology More...PROⁱ	PR:P11279
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000185896 Expressed in 245 organ(s), highest expression level in nephron tubule
CleanExⁱ	HS_LAMP1
ExpressionAtlasⁱ	P11279 baseline and differential
Genevisibleⁱ	P11279 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR018134 LAMP_CS IPR002000 Lysosome-assoc_membr_glycop
PANTHERⁱ	PTHR11506 PTHR11506, 1 hit
Pfamⁱ	View protein in Pfam PF01299 Lamp, 1 hit
PRINTSⁱ	PR00336 LYSASSOCTDMP
PROSITEⁱ	View protein in PROSITE PS00310 LAMP_1, 2 hits PS00311 LAMP_2, 1 hit PS51407 LAMP_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LAMP1_HUMAN
Accessionⁱ	P11279Primary (citable) accession number: P11279 Secondary accession number(s): B4DWL3 , Q8WU33, Q96I40, Q9BRD2, Q9NP13
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
	Last sequence update:	September 23, 2008
	Last modified:	November 7, 2018
	This is version 182 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM
Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries

UniProtKB

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UniProtKB - P11279 (LAMP1_HUMAN)

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Lysosome-associated membrane glycoprotein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Lysosome

Plasma membrane

Endosome

Cytosol

Endosome

Extracellular region or secreted

Lysosome

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ