UniProtKB - P11279 (LAMP1_HUMAN)
Lysosome-associated membrane glycoprotein 1
LAMP1
Functioni
Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, autophagy, and cholesterol homeostasis (By similarity).
Plays also an important role in NK-cells cytotoxicity (PubMed:23632890, PubMed:2022921).
Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule (PubMed:23632890).
In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content (PubMed:23847195).
Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis.
By similarity3 Publications(Microbial infection) Acts as a receptor for Lassa virus glycoprotein (PubMed:24970085).
Promotes also fusion of the virus with host membrane in less acidic endosomes (PubMed:29295909).
2 Publications(Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F.
1 PublicationGO - Molecular functioni
- enzyme binding Source: UniProtKB
- protein domain specific binding Source: Ensembl
- virus receptor activity Source: UniProtKB-KW
GO - Biological processi
- establishment of protein localization to organelle Source: UniProtKB
- Golgi to lysosome transport Source: UniProtKB
- granzyme-mediated programmed cell death signaling pathway Source: GO_Central
- positive regulation of natural killer cell degranulation Source: UniProtKB
- positive regulation of natural killer cell mediated cytotoxicity Source: UniProtKB
- protein stabilization Source: CAFA
- regulation of organelle transport along microtubule Source: UniProtKB
Keywordsi
Molecular function | Host cell receptor for virus entry, Receptor |
Biological process | Host-virus interaction |
Enzyme and pathway databases
PathwayCommonsi | P11279 |
Reactomei | R-HSA-6798695, Neutrophil degranulation |
SignaLinki | P11279 |
Protein family/group databases
TCDBi | 9.A.16.1.1, the lysosomal protein import (lpi) family |
Names & Taxonomyi
Protein namesi | Recommended name: Lysosome-associated membrane glycoprotein 1CuratedShort name: LAMP-1 Short name: Lysosome-associated membrane protein 1 Alternative name(s): CD107 antigen-like family member A CD_antigen: CD107a |
Gene namesi | Name:LAMP1Imported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6499, LAMP1 |
MIMi | 153330, gene |
neXtProti | NX_P11279 |
VEuPathDBi | HostDB:ENSG00000185896 |
Subcellular locationi
Endosome
- Endosome membrane ; Single-pass type I membrane protein Sequence analysis
- Late endosome membrane 1 Publication; Single-pass type I membrane protein Sequence analysis
Plasma membrane
- Cell membrane 2 Publications; Single-pass type I membrane protein Sequence analysis
Lysosome
- Lysosome membrane 2 Publications; Single-pass type I membrane protein Sequence analysis
- Cytolytic granule membrane 2 Publications; Single-pass type I membrane protein Sequence analysis
Note: This protein shuttles between lysosomes, endosomes, and the plasma membrane (By similarity). Colocalizes with OSBPL1A at the late endosome (PubMed:16176980).By similarity2 Publications
Cytosol
- cytosol Source: GOC
Endosome
- endosome membrane Source: UniProtKB
- late endosome Source: UniProtKB
- late endosome membrane Source: GO_Central
- multivesicular body Source: Ensembl
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Lysosome
- autolysosome Source: Ensembl
- azurophil granule membrane Source: Reactome
- cytolytic granule membrane Source: UniProtKB
- lysosomal membrane Source: UniProtKB
- lysosome Source: UniProtKB
- phagolysosome membrane Source: Ensembl
Plasma Membrane
- external side of plasma membrane Source: Ensembl
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: UniProtKB
- sarcolemma Source: Ensembl
Other locations
- autophagosome membrane Source: Ensembl
- cytoplasm Source: MGI
- ficolin-1-rich granule membrane Source: Reactome
- melanosome Source: Ensembl
- membrane Source: UniProtKB
- perinuclear region of cytoplasm Source: AgBase
- synaptic vesicle Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 29 – 382 | LumenalSequence analysisAdd BLAST | 354 | |
Transmembranei | 383 – 405 | HelicalPROSITE-ProRule annotationAdd BLAST | 23 | |
Topological domaini | 406 – 417 | CytoplasmicPROSITE-ProRule annotationAdd BLAST | 12 |
Keywords - Cellular componenti
Cell membrane, Endosome, Lysosome, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 76 | N → S: Complete loss of interaction with Lassa virus protein GPC. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 3916 |
OpenTargetsi | ENSG00000185896 |
PharmGKBi | PA30283 |
Miscellaneous databases
Pharosi | P11279, Tbio |
Genetic variation databases
BioMutai | LAMP1 |
DMDMi | 206729915 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 28 | 2 PublicationsAdd BLAST | 28 | |
ChainiPRO_0000017104 | 29 – 417 | Lysosome-associated membrane glycoprotein 1Add BLAST | 389 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 37 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 41 ↔ 80 | PROSITE-ProRule annotation1 Publication | ||
Glycosylationi | 45 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 62 | N-linked (GlcNAc...) (polylactosaminoglycan) asparagine2 Publications | 1 | |
Glycosylationi | 76 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Glycosylationi | 84 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 103 | N-linked (GlcNAc...) asparagine3 Publications | 1 | |
Glycosylationi | 107 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 121 | N-linked (GlcNAc...) (polylactosaminoglycan) asparagine1 Publication | 1 | |
Glycosylationi | 130 | N-linked (GlcNAc...) (polylactosaminoglycan) asparagine1 Publication | 1 | |
Disulfide bondi | 155 ↔ 191 | PROSITE-ProRule annotation1 Publication | ||
Glycosylationi | 165 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Glycosylationi | 181 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Glycosylationi | 197 | O-linked (GalNAc...) serine; partial1 Publication | 1 | |
Glycosylationi | 199 | O-linked (GalNAc...) threonine1 Publication | 1 | |
Glycosylationi | 200 | O-linked (GalNAc...) threonine1 Publication | 1 | |
Glycosylationi | 207 | O-linked (GalNAc...) serine1 Publication | 1 | |
Glycosylationi | 209 | O-linked (GalNAc...) serine1 Publication | 1 | |
Glycosylationi | 211 | O-linked (GalNAc...) serine1 Publication | 1 | |
Glycosylationi | 223 | N-linked (GlcNAc...) (polylactosaminoglycan) asparagine1 Publication | 1 | |
Glycosylationi | 228 | N-linked (GlcNAc...) (polylactosaminoglycan) asparagine1 Publication | 1 | |
Disulfide bondi | 231 ↔ 269 | PROSITE-ProRule annotation1 Publication | ||
Glycosylationi | 241 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 249 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Glycosylationi | 261 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Glycosylationi | 293 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 322 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 338 ↔ 375 | PROSITE-ProRule annotation1 Publication |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | P11279 |
jPOSTi | P11279 |
MassIVEi | P11279 |
MaxQBi | P11279 |
PaxDbi | P11279 |
PeptideAtlasi | P11279 |
PRIDEi | P11279 |
ProteomicsDBi | 52734 [P11279-1] 5353 |
TopDownProteomicsi | P11279-1 [P11279-1] |
PTM databases
GlyConnecti | 355, 114 N-Linked glycans (10 sites), 3 O-Linked glycans |
GlyGeni | P11279, 29 sites, 166 N-linked glycans (10 sites), 11 O-linked glycans (7 sites) |
iPTMneti | P11279 |
PhosphoSitePlusi | P11279 |
SwissPalmi | P11279 |
Expressioni
Gene expression databases
Bgeei | ENSG00000185896, Expressed in nephron tubule and 258 other tissues |
ExpressionAtlasi | P11279, baseline and differential |
Genevisiblei | P11279, HS |
Organism-specific databases
HPAi | ENSG00000185896, Low tissue specificity |
Interactioni
Subunit structurei
(Microbial infection) Interacts with Lassa virus protein glycoprotein.
1 Publication(Microbial infection) Interacts with mumps virus protein F; this interaction promotes protein F cleavage by FURIN.
1 PublicationBinary interactionsi
P11279
GO - Molecular functioni
- enzyme binding Source: UniProtKB
- protein domain specific binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 110110, 553 interactors |
DIPi | DIP-44670N |
ELMi | P11279 |
IntActi | P11279, 345 interactors |
MINTi | P11279 |
STRINGi | 9606.ENSP00000333298 |
Miscellaneous databases
RNActi | P11279, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 29 – 194 | First lumenal domainAdd BLAST | 166 | |
Regioni | 184 – 221 | DisorderedSequence analysisAdd BLAST | 38 | |
Regioni | 195 – 227 | HingeAdd BLAST | 33 | |
Regioni | 228 – 382 | Second lumenal domainAdd BLAST | 155 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 198 – 215 | Pro residuesSequence analysisAdd BLAST | 18 |
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4818, Eukaryota |
GeneTreei | ENSGT00950000182899 |
HOGENOMi | CLU_055379_2_0_1 |
InParanoidi | P11279 |
OMAi | ETRCKQD |
OrthoDBi | 993446at2759 |
PhylomeDBi | P11279 |
TreeFami | TF316339 |
Family and domain databases
InterProi | View protein in InterPro IPR018134, LAMP_CS IPR002000, Lysosome-assoc_membr_glycop |
PANTHERi | PTHR11506, PTHR11506, 1 hit |
Pfami | View protein in Pfam PF01299, Lamp, 1 hit |
PRINTSi | PR00336, LYSASSOCTDMP |
PROSITEi | View protein in PROSITE PS00310, LAMP_1, 2 hits PS00311, LAMP_2, 1 hit PS51407, LAMP_3, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAPGSARRP LLLLLLLLLL GLMHCASAAM FMVKNGNGTA CIMANFSAAF
60 70 80 90 100
SVNYDTKSGP KNMTFDLPSD ATVVLNRSSC GKENTSDPSL VIAFGRGHTL
110 120 130 140 150
TLNFTRNATR YSVQLMSFVY NLSDTHLFPN ASSKEIKTVE SITDIRADID
160 170 180 190 200
KKYRCVSGTQ VHMNNVTVTL HDATIQAYLS NSSFSRGETR CEQDRPSPTT
210 220 230 240 250
APPAPPSPSP SPVPKSPSVD KYNVSGTNGT CLLASMGLQL NLTYERKDNT
260 270 280 290 300
TVTRLLNINP NKTSASGSCG AHLVTLELHS EGTTVLLFQF GMNASSSRFF
310 320 330 340 350
LQGIQLNTIL PDARDPAFKA ANGSLRALQA TVGNSYKCNA EEHVRVTKAF
360 370 380 390 400
SVNIFKVWVQ AFKVEGGQFG SVEECLLDEN SMLIPIAVGG ALAGLVLIVL
410
IAYLVGRKRS HAGYQTI
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 2 | A → M in AAA60382 (PubMed:3198605).Curated | 1 | |
Sequence conflicti | 5 | G → R in AAA60382 (PubMed:3198605).Curated | 1 | |
Sequence conflicti | 16 – 26 | LLLLLGLMHCA → PVAAARPHALS in AAA60382 (PubMed:3198605).CuratedAdd BLAST | 11 | |
Sequence conflicti | 33 – 40 | VKNGNGTA → MARGGRVR in AAA59524 (PubMed:3131762).Curated | 8 | |
Sequence conflicti | 262 | K → T in AAF66141 (PubMed:8517882).Curated | 1 | |
Sequence conflicti | 377 | Missing in AAF66141 (PubMed:8517882).Curated | 1 | |
Sequence conflicti | 382 | M → T in AAA60382 (PubMed:3198605).Curated | 1 | |
Sequence conflicti | 382 | M → T in AAA59524 (PubMed:3131762).Curated | 1 | |
Sequence conflicti | 382 | M → T in AAF66141 (PubMed:8517882).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_046450 | 309 | I → T. Corresponds to variant dbSNP:rs9577230Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056032 | 135 – 187 | Missing in isoform 2. 1 PublicationAdd BLAST | 53 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J04182 mRNA Translation: AAA60382.1 AK301584 mRNA Translation: BAG63075.1 AL136221 Genomic DNA No translation available. CH471085 Genomic DNA Translation: EAX09202.1 BC006345 mRNA Translation: AAH06345.2 BC007845 mRNA Translation: AAH07845.2 BC021288 mRNA Translation: AAH21288.1 BC093044 mRNA Translation: AAH93044.1 J03263 mRNA Translation: AAA59524.1 AH003113 Genomic DNA Translation: AAF66141.1 |
CCDSi | CCDS41909.1 [P11279-1] |
PIRi | A31959 |
RefSeqi | NP_005552.3, NM_005561.3 [P11279-1] |
Genome annotation databases
Ensembli | ENST00000332556; ENSP00000333298; ENSG00000185896 |
GeneIDi | 3916 |
KEGGi | hsa:3916 |
MANE-Selecti | ENST00000332556.5; ENSP00000333298.4; NM_005561.4; NP_005552.3 |
UCSCi | uc001vtm.2, human [P11279-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J04182 mRNA Translation: AAA60382.1 AK301584 mRNA Translation: BAG63075.1 AL136221 Genomic DNA No translation available. CH471085 Genomic DNA Translation: EAX09202.1 BC006345 mRNA Translation: AAH06345.2 BC007845 mRNA Translation: AAH07845.2 BC021288 mRNA Translation: AAH21288.1 BC093044 mRNA Translation: AAH93044.1 J03263 mRNA Translation: AAA59524.1 AH003113 Genomic DNA Translation: AAF66141.1 |
CCDSi | CCDS41909.1 [P11279-1] |
PIRi | A31959 |
RefSeqi | NP_005552.3, NM_005561.3 [P11279-1] |
3D structure databases
SMRi | P11279 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 110110, 553 interactors |
DIPi | DIP-44670N |
ELMi | P11279 |
IntActi | P11279, 345 interactors |
MINTi | P11279 |
STRINGi | 9606.ENSP00000333298 |
Protein family/group databases
TCDBi | 9.A.16.1.1, the lysosomal protein import (lpi) family |
PTM databases
GlyConnecti | 355, 114 N-Linked glycans (10 sites), 3 O-Linked glycans |
GlyGeni | P11279, 29 sites, 166 N-linked glycans (10 sites), 11 O-linked glycans (7 sites) |
iPTMneti | P11279 |
PhosphoSitePlusi | P11279 |
SwissPalmi | P11279 |
Genetic variation databases
BioMutai | LAMP1 |
DMDMi | 206729915 |
Proteomic databases
EPDi | P11279 |
jPOSTi | P11279 |
MassIVEi | P11279 |
MaxQBi | P11279 |
PaxDbi | P11279 |
PeptideAtlasi | P11279 |
PRIDEi | P11279 |
ProteomicsDBi | 52734 [P11279-1] 5353 |
TopDownProteomicsi | P11279-1 [P11279-1] |
Protocols and materials databases
ABCDi | P11279, 10 sequenced antibodies |
Antibodypediai | 2703, 1407 antibodies from 51 providers |
DNASUi | 3916 |
Genome annotation databases
Ensembli | ENST00000332556; ENSP00000333298; ENSG00000185896 |
GeneIDi | 3916 |
KEGGi | hsa:3916 |
MANE-Selecti | ENST00000332556.5; ENSP00000333298.4; NM_005561.4; NP_005552.3 |
UCSCi | uc001vtm.2, human [P11279-1] |
Organism-specific databases
CTDi | 3916 |
DisGeNETi | 3916 |
GeneCardsi | LAMP1 |
HGNCi | HGNC:6499, LAMP1 |
HPAi | ENSG00000185896, Low tissue specificity |
MIMi | 153330, gene |
neXtProti | NX_P11279 |
OpenTargetsi | ENSG00000185896 |
PharmGKBi | PA30283 |
VEuPathDBi | HostDB:ENSG00000185896 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4818, Eukaryota |
GeneTreei | ENSGT00950000182899 |
HOGENOMi | CLU_055379_2_0_1 |
InParanoidi | P11279 |
OMAi | ETRCKQD |
OrthoDBi | 993446at2759 |
PhylomeDBi | P11279 |
TreeFami | TF316339 |
Enzyme and pathway databases
PathwayCommonsi | P11279 |
Reactomei | R-HSA-6798695, Neutrophil degranulation |
SignaLinki | P11279 |
Miscellaneous databases
BioGRID-ORCSi | 3916, 9 hits in 1047 CRISPR screens |
ChiTaRSi | LAMP1, human |
GeneWikii | LAMP1 |
GenomeRNAii | 3916 |
Pharosi | P11279, Tbio |
PROi | PR:P11279 |
RNActi | P11279, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000185896, Expressed in nephron tubule and 258 other tissues |
ExpressionAtlasi | P11279, baseline and differential |
Genevisiblei | P11279, HS |
Family and domain databases
InterProi | View protein in InterPro IPR018134, LAMP_CS IPR002000, Lysosome-assoc_membr_glycop |
PANTHERi | PTHR11506, PTHR11506, 1 hit |
Pfami | View protein in Pfam PF01299, Lamp, 1 hit |
PRINTSi | PR00336, LYSASSOCTDMP |
PROSITEi | View protein in PROSITE PS00310, LAMP_1, 2 hits PS00311, LAMP_2, 1 hit PS51407, LAMP_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | LAMP1_HUMAN | |
Accessioni | P11279Primary (citable) accession number: P11279 Secondary accession number(s): B4DWL3 Q9NP13 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | September 23, 2008 | |
Last modified: | February 23, 2022 | |
This is version 205 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families