UniProtKB - P11277 (SPTB1_HUMAN)
Protein
Spectrin beta chain, erythrocytic
Gene
SPTB
Organism
Homo sapiens (Human)
Status
Functioni
Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.
Miscellaneous
This complex is anchored to the cytoplasmic face of the plasma membrane via another protein, ankyrin, which binds to beta-spectrin and mediates the binding of the whole complex to a transmembrane protein band 3. The interaction of erythrocyte spectrin with other proteins through specific binding domains lead to the formation of an extensive subplasmalemmal meshwork which is thought to be responsible for the maintenance of the biconcave shape of human erythrocytes, for the regulation of plasma membrane components and for the maintenance of the lipid asymmetry of the plasma membrane.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 165 – 166 | (Microbial infection) Cleavage; by P.falciparum SERA61 Publication | 2 | |
Sitei | 167 – 168 | (Microbial infection) Cleavage; by P.falciparum SERA61 Publication | 2 |
GO - Molecular functioni
- actin binding Source: ProtInc
- actin filament binding Source: UniProtKB
- ankyrin binding Source: BHF-UCL
- structural constituent of cytoskeleton Source: InterPro
GO - Biological processi
- actin filament capping Source: UniProtKB-KW
- axon guidance Source: Reactome
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: Reactome
- MAPK cascade Source: Reactome
Keywordsi
Molecular function | Actin capping, Actin-binding |
Enzyme and pathway databases
PathwayCommonsi | P11277 |
Reactomei | R-HSA-375165, NCAM signaling for neurite out-growth R-HSA-445095, Interaction between L1 and Ankyrins R-HSA-5673001, RAF/MAP kinase cascade R-HSA-6807878, COPI-mediated anterograde transport |
Names & Taxonomyi
Protein namesi | Recommended name: Spectrin beta chain, erythrocyticAlternative name(s): Beta-I spectrin |
Gene namesi | Name:SPTB Synonyms:SPTB1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11274, SPTB |
MIMi | 182870, gene |
neXtProti | NX_P11277 |
VEuPathDBi | HostDB:ENSG00000070182.17 |
Subcellular locationi
Cytoskeleton
Other locations
Cytoskeleton
- actin cytoskeleton Source: BHF-UCL
- spectrin Source: ProtInc
- spectrin-associated cytoskeleton Source: BHF-UCL
Cytosol
- cytosol Source: HPA
Plasma Membrane
Other locations
- cell surface Source: UniProtKB
- protein-containing complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPathology & Biotechi
Involvement in diseasei
Elliptocytosis 3 (EL3)4 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous hematologic disorder characterized by variable hemolytic anemia and elliptical or oval red cell shape. Inheritance can be autosomal dominant or autosomal recessive.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_001357 | 2018 | A → G in EL3; Cagliary. 1 PublicationCorresponds to variant dbSNP:rs121918647EnsemblClinVar. | 1 | |
Natural variantiVAR_001358 | 2019 | S → P in EL3; Providence. 1 PublicationCorresponds to variant dbSNP:rs121918648EnsemblClinVar. | 1 | |
Natural variantiVAR_001359 | 2023 | A → V in EL3; Paris. 1 PublicationCorresponds to variant dbSNP:rs367841692Ensembl. | 1 | |
Natural variantiVAR_001360 | 2024 | W → R in EL3; Linguere. 1 PublicationCorresponds to variant dbSNP:rs1225539653Ensembl. | 1 | |
Natural variantiVAR_001361 | 2025 | L → R in EL3; Buffalo. Corresponds to variant dbSNP:rs121918649EnsemblClinVar. | 1 | |
Natural variantiVAR_001362 | 2053 | A → P in EL3; Kayes. 1 PublicationCorresponds to variant dbSNP:rs121918645EnsemblClinVar. | 1 |
Spherocytosis 2 (SPH2)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant form of hereditary spherocytosis, a group of hematologic disorders characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. Clinical manifestations include chronic hemolytic anemia, jaundice, and splenomegaly, with variable severity.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_001352 | 202 | W → R in SPH2; spectrin Kissimmee. 1 PublicationCorresponds to variant dbSNP:rs121918646EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variant, Elliptocytosis, Hereditary hemolytic anemiaOrganism-specific databases
DisGeNETi | 6710 |
MalaCardsi | SPTB |
MIMi | 616649, phenotype 617948, phenotype |
OpenTargetsi | ENSG00000070182 |
Orphaneti | 288, Hereditary elliptocytosis 822, Hereditary spherocytosis |
PharmGKBi | PA36103 |
Miscellaneous databases
Pharosi | P11277, Tbio |
Genetic variation databases
BioMutai | SPTB |
DMDMi | 215274269 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000073459 | 2 – 2137 | Spectrin beta chain, erythrocyticAdd BLAST | 2136 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 36 | PhosphoserineBy similarity | 1 | |
Modified residuei | 104 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1297 | PhosphoserineBy similarity | 1 | |
Modified residuei | 2043 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2073 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 2110 | Phosphothreonine1 Publication | 1 | |
Modified residuei | 2114 | Phosphoserine1 Publication | 1 | |
Modified residuei | 2117 | Phosphoserine1 Publication | 1 | |
Modified residuei | 2123 | PhosphoserineCombined sources1 Publication | 1 | |
Modified residuei | 2125 | PhosphoserineCombined sources1 Publication | 1 | |
Modified residuei | 2128 | Phosphoserine1 Publication | 1 |
Post-translational modificationi
The first phosphorylation event occurs on Ser-2114, followed by Ser-2125, Ser-2123, Ser-2128, Ser-2117, and Thr-2110.1 Publication
(Microbial infection) Probably cleaved by P.falciparum SERA6; the cleavage results in SPTB solubilisation causing the disruption of the actin cytoskeleton and the rupture of the erythrocyte cell membrane releasing the merozoites.1 Publication
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | P11277 |
jPOSTi | P11277 |
MassIVEi | P11277 |
MaxQBi | P11277 |
PaxDbi | P11277 |
PeptideAtlasi | P11277 |
PRIDEi | P11277 |
ProteomicsDBi | 52731 [P11277-1] 52732 [P11277-2] 52733 [P11277-3] |
2D gel databases
SWISS-2DPAGEi | P11277 |
PTM databases
CarbonylDBi | P11277 |
GlyConnecti | 2860, 1 O-Linked glycan (5 sites) |
iPTMneti | P11277 |
MetOSitei | P11277 |
PhosphoSitePlusi | P11277 |
Expressioni
Gene expression databases
Bgeei | ENSG00000070182, Expressed in gastrocnemius and 177 other tissues |
ExpressionAtlasi | P11277, baseline and differential |
Genevisiblei | P11277, HS |
Organism-specific databases
HPAi | ENSG00000070182, Tissue enhanced (bone marrow, brain, skeletal muscle) |
Interactioni
Subunit structurei
Composed of nonhomologous chains, alpha and beta, which aggregate to form dimers, tetramers, and higher polymers.
Binary interactionsi
Hide detailsP11277
With | #Exp. | IntAct |
---|---|---|
APP [P05067] | 6 | EBI-514908,EBI-77613 |
SNAPIN [O95295] | 3 | EBI-514908,EBI-296723 |
SPTA1 [P02549] | 4 | EBI-514908,EBI-375617 |
Csrp3 [P50463] from Rattus norvegicus. | 6 | EBI-514908,EBI-12502290 |
GO - Molecular functioni
- actin binding Source: ProtInc
- actin filament binding Source: UniProtKB
- ankyrin binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 112588, 31 interactors |
DIPi | DIP-1021N |
IntActi | P11277, 23 interactors |
STRINGi | 9606.ENSP00000451752 |
Miscellaneous databases
RNActi | P11277, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P11277 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P11277 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 54 – 158 | Calponin-homology (CH) 1PROSITE-ProRule annotationAdd BLAST | 105 | |
Domaini | 173 – 278 | Calponin-homology (CH) 2PROSITE-ProRule annotationAdd BLAST | 106 | |
Repeati | 303 – 411 | Spectrin 1Sequence analysisAdd BLAST | 109 | |
Repeati | 423 – 525 | Spectrin 2Sequence analysisAdd BLAST | 103 | |
Repeati | 529 – 635 | Spectrin 3Sequence analysisAdd BLAST | 107 | |
Repeati | 638 – 741 | Spectrin 4Sequence analysisAdd BLAST | 104 | |
Repeati | 744 – 846 | Spectrin 5Sequence analysisAdd BLAST | 103 | |
Repeati | 851 – 950 | Spectrin 6Sequence analysisAdd BLAST | 100 | |
Repeati | 956 – 1058 | Spectrin 7Sequence analysisAdd BLAST | 103 | |
Repeati | 1062 – 1165 | Spectrin 8Sequence analysisAdd BLAST | 104 | |
Repeati | 1170 – 1257 | Spectrin 9Sequence analysisAdd BLAST | 88 | |
Repeati | 1275 – 1375 | Spectrin 10Sequence analysisAdd BLAST | 101 | |
Repeati | 1389 – 1465 | Spectrin 11Sequence analysisAdd BLAST | 77 | |
Repeati | 1481 – 1582 | Spectrin 12Sequence analysisAdd BLAST | 102 | |
Repeati | 1585 – 1688 | Spectrin 13Sequence analysisAdd BLAST | 104 | |
Repeati | 1690 – 1793 | Spectrin 14Sequence analysisAdd BLAST | 104 | |
Repeati | 1797 – 1899 | Spectrin 15Sequence analysisAdd BLAST | 103 | |
Repeati | 1906 – 2006 | Spectrin 16Sequence analysisAdd BLAST | 101 | |
Repeati | 2013 – 2075 | Spectrin 17Sequence analysisAdd BLAST | 63 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 2 – 275 | Actin-bindingAdd BLAST | 274 |
Sequence similaritiesi
Belongs to the spectrin family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0517, Eukaryota |
GeneTreei | ENSGT00940000158908 |
HOGENOMi | CLU_000146_1_2_1 |
InParanoidi | P11277 |
OMAi | HRMWESR |
OrthoDBi | 543832at2759 |
PhylomeDBi | P11277 |
TreeFami | TF313446 |
Family and domain databases
CDDi | cd00014, CH, 2 hits |
Gene3Di | 1.10.418.10, 2 hits |
InterProi | View protein in InterPro IPR001589, Actinin_actin-bd_CS IPR001715, CH-domain IPR036872, CH_dom_sf IPR018159, Spectrin/alpha-actinin IPR016343, Spectrin_bsu IPR002017, Spectrin_repeat |
Pfami | View protein in Pfam PF00307, CH, 2 hits PF00435, Spectrin, 17 hits |
PIRSFi | PIRSF002297, Spectrin_beta_subunit, 1 hit |
SMARTi | View protein in SMART SM00033, CH, 2 hits SM00150, SPEC, 17 hits |
SUPFAMi | SSF47576, SSF47576, 1 hit |
PROSITEi | View protein in PROSITE PS00019, ACTININ_1, 1 hit PS00020, ACTININ_2, 1 hit PS50021, CH, 2 hits |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: P11277-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTSATEFENV GNQPPYSRIN ARWDAPDDEL DNDNSSARLF ERSRIKALAD
60 70 80 90 100
EREVVQKKTF TKWVNSHLAR VSCRITDLYK DLRDGRMLIK LLEVLSGEML
110 120 130 140 150
PKPTKGKMRI HCLENVDKAL QFLKEQRVHL ENMGSHDIVD GNHRLVLGLI
160 170 180 190 200
WTIILRFQIQ DIVVQTQEGR ETRSAKDALL LWCQMKTAGY PHVNVTNFTS
210 220 230 240 250
SWKDGLAFNA LIHKHRPDLI DFDKLKDSNA RHNLEHAFNV AERQLGIIPL
260 270 280 290 300
LDPEDVFTEN PDEKSIITYV VAFYHYFSKM KVLAVEGKRV GKVIDHAIET
310 320 330 340 350
EKMIEKYSGL ASDLLTWIEQ TITVLNSRKF ANSLTGVQQQ LQAFSTYRTV
360 370 380 390 400
EKPPKFQEKG NLEVLLFTIQ SRMRANNQKV YTPHDGKLVS DINRAWESLE
410 420 430 440 450
EAEYRRELAL RNELIRQEKL EQLARRFDRK AAMRETWLSE NQRLVAQDNF
460 470 480 490 500
GYDLAAVEAA KKKHEAIETD TAAYEERVRA LEDLAQELEK ENYHDQKRIT
510 520 530 540 550
ARKDNILRLW SYLQELLQSR RQRLETTLAL QKLFQDMLHS IDWMDEIKAH
560 570 580 590 600
LLSAEFGKHL LEVEDLLQKH KLMEADIAIQ GDKVKAITAA TLKFTEGKGY
610 620 630 640 650
QPCDPQVIQD RISHLEQCFE ELSNMAAGRK AQLEQSKRLW KFFWEMDEAE
660 670 680 690 700
SWIKEKEQIY SSLDYGKDLT SVLILQRKHK AFEDELRGLD AHLEQIFQEA
710 720 730 740 750
HGMVARKQFG HPQIEARIKE VSAQWDQLKD LAAFCKKNLQ DAENFFQFQG
760 770 780 790 800
DADDLKAWLQ DAHRLLSGED VGQDEGATRA LGKKHKDFLE ELEESRGVME
810 820 830 840 850
HLEQQAQGFP EEFRDSPDVT HRLQALRELY QQVVAQADLR QQRLQEALDL
860 870 880 890 900
YTVFGETDAC ELWMGEKEKW LAEMEMPDTL EDLEVVQHRF DILDQEMKTL
910 920 930 940 950
MTQIDGVNLA ANSLVESGHP RSREVKQYQD HLNTRWQAFQ TLVSERREAV
960 970 980 990 1000
DSALRVHNYC VDCEETSKWI TDKTKVVEST KDLGRDLAGI IAIQRKLSGL
1010 1020 1030 1040 1050
ERDVAAIQAR VDALERESQQ LMDSHPEQKE DIGQRQKHLE ELWQGLQQSL
1060 1070 1080 1090 1100
QGQEDLLGEV SQLQAFLQDL DDFQAWLSIT QKAVASEDMP ESLPEAEQLL
1110 1120 1130 1140 1150
QQHAGIKDEI DGHQDSYQRV KESGEKVIQG QTDPEYLLLG QRLEGLDTGW
1160 1170 1180 1190 1200
NALGRMWESR SHTLAQCLGF QEFQKDAKQA EAILSNQEYT LAHLEPPDSL
1210 1220 1230 1240 1250
EAAEAGIRKF EDFLGSMENN RDKVLSPVDS GNKLVAEGNL YSDKIKEKVQ
1260 1270 1280 1290 1300
LIEDRHRKNN EKAQEASVLL RDNLELQNFL QNCQELTLWI NDKLLTSQDV
1310 1320 1330 1340 1350
SYDEARNLHN KWLKHQAFVA ELASHEGWLE NIDAEGKQLM DEKPQFTALV
1360 1370 1380 1390 1400
SQKLEALHRL WDELQATTKE KTQHLSAARS SDLRLQTHAD LNKWISAMED
1410 1420 1430 1440 1450
QLRSDDPGKD LTSVNRMLAK LKRVEDQVNV RKEELGELFA QVPSMGEEGG
1460 1470 1480 1490 1500
DADLSIEKRF LDLLEPLGRR KKQLESSRAK LQISRDLEDE TLWVEERLPL
1510 1520 1530 1540 1550
AQSADYGTNL QTVQLFMKKN QTLQNEILGH TPRVEDVLQR GQQLVEAAEI
1560 1570 1580 1590 1600
DCQDLEERLG HLQSSWDRLR EAAAGRLQRL RDANEAQQYY LDADEAEAWI
1610 1620 1630 1640 1650
GEQELYVISD EIPKDEEGAI VMLKRHLRQQ RAVEDYGRNI KQLASRAQGL
1660 1670 1680 1690 1700
LSAGHPEGEQ IIRLQGQVDK HYAGLKDVAE ERKRKLENMY HLFQLKRETD
1710 1720 1730 1740 1750
DLEQWISEKE LVASSPEMGQ DFDHVTLLRD KFRDFARETG AIGQERVDNV
1760 1770 1780 1790 1800
NAFIERLIDA GHSEAATIAE WKDGLNEMWA DLLELIDTRM QLLAASYDLH
1810 1820 1830 1840 1850
RYFYTGAEIL GLIDEKHREL PEDVGLDAST AESFHRVHTA FERELHLLGV
1860 1870 1880 1890 1900
QVQQFQDVAT RLQTAYAGEK AEAIQNKEQE VSAAWQALLD ACAGRRTQLV
1910 1920 1930 1940 1950
DTADKFRFFS MARDLLSWME SIIRQIETQE RPRDVSSVEL LMKYHQGINA
1960 1970 1980 1990 2000
EIETRSKNFS ACLELGESLL QRQHQASEEI REKLQQVMSR RKEMNEKWEA
2010 2020 2030 2040 2050
RWERLRMLLE VCQFSRDASV AEAWLIAQEP YLASGDFGHT VDSVEKLIKR
2060 2070 2080 2090 2100
HEAFEKSTAS WAERFAALEK PTTLELKERQ IAERPAEETG PQEEEGETAG
2110 2120 2130
EAPVSHHAAT ERTSPVSLWS RLSSSWESLQ PEPSHPY
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH0YJE6 | H0YJE6_HUMAN | Spectrin beta chain, erythrocytic | SPTB | 1,028 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 403 | E → G in AAA60578 (PubMed:2195026).Curated | 1 | |
Sequence conflicti | 403 | E → G in AAA60579 (PubMed:2195026).Curated | 1 | |
Sequence conflicti | 612 | I → M in AAA60578 (PubMed:2195026).Curated | 1 | |
Sequence conflicti | 612 | I → M in AAA60579 (PubMed:2195026).Curated | 1 | |
Sequence conflicti | 629 – 631 | RKA → ART in AAA60578 (PubMed:2195026).Curated | 3 | |
Sequence conflicti | 629 – 631 | RKA → ART in AAA60579 (PubMed:2195026).Curated | 3 | |
Sequence conflicti | 958 – 959 | NY → TL in AAA60578 (PubMed:2195026).Curated | 2 | |
Sequence conflicti | 958 – 959 | NY → TL in AAA60579 (PubMed:2195026).Curated | 2 | |
Sequence conflicti | 1031 | D → N in AAA60578 (PubMed:2195026).Curated | 1 | |
Sequence conflicti | 1031 | D → N in AAA60579 (PubMed:2195026).Curated | 1 | |
Sequence conflicti | 1844 – 1845 | EL → DV in AAA60578 (PubMed:2195026).Curated | 2 | |
Sequence conflicti | 1844 – 1845 | EL → DV in AAA60579 (PubMed:2195026).Curated | 2 | |
Sequence conflicti | 1844 – 1845 | EL → DV in AAA63259 (PubMed:2056132).Curated | 2 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_001352 | 202 | W → R in SPH2; spectrin Kissimmee. 1 PublicationCorresponds to variant dbSNP:rs121918646EnsemblClinVar. | 1 | |
Natural variantiVAR_001353 | 439 | S → N1 PublicationCorresponds to variant dbSNP:rs229587EnsemblClinVar. | 1 | |
Natural variantiVAR_061084 | 525 | E → K. Corresponds to variant dbSNP:rs55752508Ensembl. | 1 | |
Natural variantiVAR_038514 | 613 | S → I. Corresponds to variant dbSNP:rs3742601EnsemblClinVar. | 1 | |
Natural variantiVAR_001354 | 1151 | N → D3 PublicationsCorresponds to variant dbSNP:rs77806EnsemblClinVar. | 1 | |
Natural variantiVAR_001355 | 1374 | H → R1 PublicationCorresponds to variant dbSNP:rs10132778EnsemblClinVar. | 1 | |
Natural variantiVAR_001356 | 1403 | R → Q. Corresponds to variant dbSNP:rs17180350EnsemblClinVar. | 1 | |
Natural variantiVAR_038515 | 1408 | G → R. Corresponds to variant dbSNP:rs17245552EnsemblClinVar. | 1 | |
Natural variantiVAR_001357 | 2018 | A → G in EL3; Cagliary. 1 PublicationCorresponds to variant dbSNP:rs121918647EnsemblClinVar. | 1 | |
Natural variantiVAR_001358 | 2019 | S → P in EL3; Providence. 1 PublicationCorresponds to variant dbSNP:rs121918648EnsemblClinVar. | 1 | |
Natural variantiVAR_001359 | 2023 | A → V in EL3; Paris. 1 PublicationCorresponds to variant dbSNP:rs367841692Ensembl. | 1 | |
Natural variantiVAR_001360 | 2024 | W → R in EL3; Linguere. 1 PublicationCorresponds to variant dbSNP:rs1225539653Ensembl. | 1 | |
Natural variantiVAR_001361 | 2025 | L → R in EL3; Buffalo. Corresponds to variant dbSNP:rs121918649EnsemblClinVar. | 1 | |
Natural variantiVAR_001362 | 2053 | A → P in EL3; Kayes. 1 PublicationCorresponds to variant dbSNP:rs121918645EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_007242 | 2074 – 2137 | LELKE…PSHPY → ASRGGRRDSRGGSSFPPCGH RENVPGQSLVSFV in isoform 3. 1 PublicationAdd BLAST | 64 | |
Alternative sequenceiVSP_000719 | 2116 – 2137 | VSLWS…PSHPY → GEEEGTWPQNLQQPPPPGQH KDGQKSTGDERPTTEPLFKV LDTPLSEGDEPATLPAPRDH GQSVQMEGYLGRKHDLEGPN KKASNRSWNNLYCVLRNSEL TFYKDAKNLALGMPYHGEEP LALRHAICEIAANYKKKKHV FKLRLSNGSEWLFHGKDEEE MLSWLQGVSTAINESQSIRV KAQSLPLPSLSGPDASLGKK DKEKRFSFFPKKK in isoform 2. 1 PublicationAdd BLAST | 22 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J05500 mRNA Translation: AAA60578.1 J05500 mRNA Translation: AAA60579.1 AL121774 Genomic DNA No translation available. M37884 mRNA Translation: AAA63259.1 M37885 mRNA Translation: AAA60571.1 M57948 mRNA No translation available. X59510 mRNA Translation: CAA42097.1 X59511 mRNA Translation: CAA42098.1 M18054 mRNA Translation: AAA60572.1 |
CCDSi | CCDS32099.1 [P11277-2] CCDS32100.1 [P11277-1] |
PIRi | A37064, SJHUB |
RefSeqi | NP_000338.3, NM_000347.5 NP_001020029.1, NM_001024858.2 [P11277-2] XP_005268080.1, XM_005268023.4 XP_016877101.1, XM_017021612.1 [P11277-2] XP_016877103.1, XM_017021614.1 |
Genome annotation databases
Ensembli | ENST00000389720; ENSP00000374370; ENSG00000070182 [P11277-1] ENST00000389722; ENSP00000374372; ENSG00000070182 [P11277-2] ENST00000644917; ENSP00000495909; ENSG00000070182 [P11277-2] |
GeneIDi | 6710 |
KEGGi | hsa:6710 |
UCSCi | uc001xhr.4, human [P11277-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J05500 mRNA Translation: AAA60578.1 J05500 mRNA Translation: AAA60579.1 AL121774 Genomic DNA No translation available. M37884 mRNA Translation: AAA63259.1 M37885 mRNA Translation: AAA60571.1 M57948 mRNA No translation available. X59510 mRNA Translation: CAA42097.1 X59511 mRNA Translation: CAA42098.1 M18054 mRNA Translation: AAA60572.1 |
CCDSi | CCDS32099.1 [P11277-2] CCDS32100.1 [P11277-1] |
PIRi | A37064, SJHUB |
RefSeqi | NP_000338.3, NM_000347.5 NP_001020029.1, NM_001024858.2 [P11277-2] XP_005268080.1, XM_005268023.4 XP_016877101.1, XM_017021612.1 [P11277-2] XP_016877103.1, XM_017021614.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1S35 | X-ray | 2.40 | A | 1063-1275 | [»] | |
3EDU | X-ray | 2.10 | A | 1692-1907 | [»] | |
3F57 | X-ray | 2.90 | A/B | 1686-1907 | [»] | |
3KBT | X-ray | 2.75 | A/B | 1583-1906 | [»] | |
3KBU | X-ray | 2.75 | A/B | 1583-1906 | [»] | |
3LBX | X-ray | 2.80 | B | 1902-2084 | [»] | |
SMRi | P11277 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112588, 31 interactors |
DIPi | DIP-1021N |
IntActi | P11277, 23 interactors |
STRINGi | 9606.ENSP00000451752 |
PTM databases
CarbonylDBi | P11277 |
GlyConnecti | 2860, 1 O-Linked glycan (5 sites) |
iPTMneti | P11277 |
MetOSitei | P11277 |
PhosphoSitePlusi | P11277 |
Genetic variation databases
BioMutai | SPTB |
DMDMi | 215274269 |
2D gel databases
SWISS-2DPAGEi | P11277 |
Proteomic databases
EPDi | P11277 |
jPOSTi | P11277 |
MassIVEi | P11277 |
MaxQBi | P11277 |
PaxDbi | P11277 |
PeptideAtlasi | P11277 |
PRIDEi | P11277 |
ProteomicsDBi | 52731 [P11277-1] 52732 [P11277-2] 52733 [P11277-3] |
Protocols and materials databases
ABCDi | P11277, 1 sequenced antibody |
Antibodypediai | 183, 109 antibodies |
Genome annotation databases
Ensembli | ENST00000389720; ENSP00000374370; ENSG00000070182 [P11277-1] ENST00000389722; ENSP00000374372; ENSG00000070182 [P11277-2] ENST00000644917; ENSP00000495909; ENSG00000070182 [P11277-2] |
GeneIDi | 6710 |
KEGGi | hsa:6710 |
UCSCi | uc001xhr.4, human [P11277-1] |
Organism-specific databases
CTDi | 6710 |
DisGeNETi | 6710 |
GeneCardsi | SPTB |
HGNCi | HGNC:11274, SPTB |
HPAi | ENSG00000070182, Tissue enhanced (bone marrow, brain, skeletal muscle) |
MalaCardsi | SPTB |
MIMi | 182870, gene 616649, phenotype 617948, phenotype |
neXtProti | NX_P11277 |
OpenTargetsi | ENSG00000070182 |
Orphaneti | 288, Hereditary elliptocytosis 822, Hereditary spherocytosis |
PharmGKBi | PA36103 |
VEuPathDBi | HostDB:ENSG00000070182.17 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0517, Eukaryota |
GeneTreei | ENSGT00940000158908 |
HOGENOMi | CLU_000146_1_2_1 |
InParanoidi | P11277 |
OMAi | HRMWESR |
OrthoDBi | 543832at2759 |
PhylomeDBi | P11277 |
TreeFami | TF313446 |
Enzyme and pathway databases
PathwayCommonsi | P11277 |
Reactomei | R-HSA-375165, NCAM signaling for neurite out-growth R-HSA-445095, Interaction between L1 and Ankyrins R-HSA-5673001, RAF/MAP kinase cascade R-HSA-6807878, COPI-mediated anterograde transport |
Miscellaneous databases
BioGRID-ORCSi | 6710, 8 hits in 871 CRISPR screens |
ChiTaRSi | SPTB, human |
EvolutionaryTracei | P11277 |
GeneWikii | SPTB |
GenomeRNAii | 6710 |
Pharosi | P11277, Tbio |
PROi | PR:P11277 |
RNActi | P11277, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000070182, Expressed in gastrocnemius and 177 other tissues |
ExpressionAtlasi | P11277, baseline and differential |
Genevisiblei | P11277, HS |
Family and domain databases
CDDi | cd00014, CH, 2 hits |
Gene3Di | 1.10.418.10, 2 hits |
InterProi | View protein in InterPro IPR001589, Actinin_actin-bd_CS IPR001715, CH-domain IPR036872, CH_dom_sf IPR018159, Spectrin/alpha-actinin IPR016343, Spectrin_bsu IPR002017, Spectrin_repeat |
Pfami | View protein in Pfam PF00307, CH, 2 hits PF00435, Spectrin, 17 hits |
PIRSFi | PIRSF002297, Spectrin_beta_subunit, 1 hit |
SMARTi | View protein in SMART SM00033, CH, 2 hits SM00150, SPEC, 17 hits |
SUPFAMi | SSF47576, SSF47576, 1 hit |
PROSITEi | View protein in PROSITE PS00019, ACTININ_1, 1 hit PS00020, ACTININ_2, 1 hit PS50021, CH, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SPTB1_HUMAN | |
Accessioni | P11277Primary (citable) accession number: P11277 Secondary accession number(s): Q15510, Q15519 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | November 25, 2008 | |
Last modified: | February 10, 2021 | |
This is version 214 of the entry and version 5 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families