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UniProtKB - P11277 (SPTB1_HUMAN)

Protein

Spectrin beta chain, erythrocytic

Gene

SPTB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.

Miscellaneous

This complex is anchored to the cytoplasmic face of the plasma membrane via another protein, ankyrin, which binds to beta-spectrin and mediates the binding of the whole complex to a transmembrane protein band 3. The interaction of erythrocyte spectrin with other proteins through specific binding domains lead to the formation of an extensive subplasmalemmal meshwork which is thought to be responsible for the maintenance of the biconcave shape of human erythrocytes, for the regulation of plasma membrane components and for the maintenance of the lipid asymmetry of the plasma membrane.

GO - Molecular functioni

  • actin binding Source: ProtInc
  • actin filament binding Source: UniProtKB
  • ankyrin binding Source: BHF-UCL
  • Ras guanyl-nucleotide exchange factor activity Source: Reactome
  • structural constituent of cytoskeleton Source: InterPro
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionActin capping, Actin-binding

Enzyme and pathway databases

ReactomeiR-HSA-375165 NCAM signaling for neurite out-growth
R-HSA-445095 Interaction between L1 and Ankyrins
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6807878 COPI-mediated anterograde transport

Names & Taxonomyi

Protein namesi
Recommended name:
Spectrin beta chain, erythrocytic
Alternative name(s):
Beta-I spectrin
Gene namesi
Name:SPTB
Synonyms:SPTB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000070182.17
HGNCiHGNC:11274 SPTB
MIMi182870 gene
neXtProtiNX_P11277

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Involvement in diseasei

Elliptocytosis 3 (EL3)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous hematologic disorder characterized by variable hemolytic anemia and elliptical or oval red cell shape. Inheritance can be autosomal dominant or autosomal recessive.
See also OMIM:617948
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0013572018A → G in EL3; Cagliary. 1 PublicationCorresponds to variant dbSNP:rs121918647EnsemblClinVar.1
Natural variantiVAR_0013582019S → P in EL3; Providence. 1 PublicationCorresponds to variant dbSNP:rs121918648EnsemblClinVar.1
Natural variantiVAR_0013592023A → V in EL3; Paris. 1 PublicationCorresponds to variant dbSNP:rs367841692Ensembl.1
Natural variantiVAR_0013602024W → R in EL3; Linguere. 1 PublicationCorresponds to variant dbSNP:rs1225539653Ensembl.1
Natural variantiVAR_0013612025L → R in EL3; Buffalo. Corresponds to variant dbSNP:rs121918649EnsemblClinVar.1
Natural variantiVAR_0013622053A → P in EL3; Kayes. 1 PublicationCorresponds to variant dbSNP:rs121918645EnsemblClinVar.1
Spherocytosis 2 (SPH2)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant form of hereditary spherocytosis, a group of hematologic disorders characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. Clinical manifestations include chronic hemolytic anemia, jaundice, and splenomegaly, with variable severity.
See also OMIM:616649
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_001352202W → R in SPH2; spectrin Kissimmee. 1 PublicationCorresponds to variant dbSNP:rs121918646EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Elliptocytosis, Hereditary hemolytic anemia

Organism-specific databases

DisGeNETi6710
MalaCardsiSPTB
MIMi616649 phenotype
617948 phenotype
OpenTargetsiENSG00000070182
Orphaneti288 Hereditary elliptocytosis
822 Hereditary spherocytosis
PharmGKBiPA36103

Polymorphism and mutation databases

BioMutaiSPTB
DMDMi215274269

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000734592 – 2137Spectrin beta chain, erythrocyticAdd BLAST2136

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei36PhosphoserineBy similarity1
Modified residuei104PhosphothreonineCombined sources1
Modified residuei1297PhosphoserineBy similarity1
Modified residuei2043PhosphoserineCombined sources1
Modified residuei2073PhosphothreonineCombined sources1
Modified residuei2110Phosphothreonine1 Publication1
Modified residuei2114Phosphoserine1 Publication1
Modified residuei2117Phosphoserine1 Publication1
Modified residuei2123PhosphoserineCombined sources1 Publication1
Modified residuei2125PhosphoserineCombined sources1 Publication1
Modified residuei2128Phosphoserine1 Publication1

Post-translational modificationi

The first phosphorylation event occurs on Ser-2114, followed by Ser-2125, Ser-2123, Ser-2128, Ser-2117, and Thr-2110.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP11277
MaxQBiP11277
PaxDbiP11277
PeptideAtlasiP11277
PRIDEiP11277
ProteomicsDBi52731
52732 [P11277-2]
52733 [P11277-3]

2D gel databases

SWISS-2DPAGEiP11277

PTM databases

CarbonylDBiP11277
iPTMnetiP11277
PhosphoSitePlusiP11277

Expressioni

Gene expression databases

BgeeiENSG00000070182 Expressed in 165 organ(s), highest expression level in gastrocnemius
CleanExiHS_SPTB
ExpressionAtlasiP11277 baseline and differential
GenevisibleiP11277 HS

Organism-specific databases

HPAiCAB015169
CAB016232
HPA003394
HPA003398

Interactioni

Subunit structurei

Composed of nonhomologous chains, alpha and beta, which aggregate to form dimers, tetramers, and higher polymers.

Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi112588, 27 interactors
DIPiDIP-1021N
IntActiP11277, 10 interactors
STRINGi9606.ENSP00000374372

Structurei

Secondary structure

12137
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP11277
SMRiP11277
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP11277

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 158Calponin-homology (CH) 1PROSITE-ProRule annotationAdd BLAST105
Domaini173 – 278Calponin-homology (CH) 2PROSITE-ProRule annotationAdd BLAST106
Repeati303 – 411Spectrin 1Sequence analysisAdd BLAST109
Repeati423 – 525Spectrin 2Sequence analysisAdd BLAST103
Repeati529 – 635Spectrin 3Sequence analysisAdd BLAST107
Repeati638 – 741Spectrin 4Sequence analysisAdd BLAST104
Repeati744 – 846Spectrin 5Sequence analysisAdd BLAST103
Repeati851 – 950Spectrin 6Sequence analysisAdd BLAST100
Repeati956 – 1058Spectrin 7Sequence analysisAdd BLAST103
Repeati1062 – 1165Spectrin 8Sequence analysisAdd BLAST104
Repeati1170 – 1257Spectrin 9Sequence analysisAdd BLAST88
Repeati1275 – 1375Spectrin 10Sequence analysisAdd BLAST101
Repeati1389 – 1465Spectrin 11Sequence analysisAdd BLAST77
Repeati1481 – 1582Spectrin 12Sequence analysisAdd BLAST102
Repeati1585 – 1688Spectrin 13Sequence analysisAdd BLAST104
Repeati1690 – 1793Spectrin 14Sequence analysisAdd BLAST104
Repeati1797 – 1899Spectrin 15Sequence analysisAdd BLAST103
Repeati1906 – 2006Spectrin 16Sequence analysisAdd BLAST101
Repeati2013 – 2075Spectrin 17Sequence analysisAdd BLAST63

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 275Actin-bindingAdd BLAST274

Sequence similaritiesi

Belongs to the spectrin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0517 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00760000118813
HOGENOMiHOG000007281
HOVERGENiHBG057912
InParanoidiP11277
KOiK06115
OMAiHRMHAAF
OrthoDBiEOG091G003V
PhylomeDBiP11277
TreeFamiTF313446

Family and domain databases

CDDicd00014 CH, 2 hits
Gene3Di1.10.418.10, 2 hits
InterProiView protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR018159 Spectrin/alpha-actinin
IPR016343 Spectrin_bsu
IPR002017 Spectrin_repeat
PfamiView protein in Pfam
PF00307 CH, 2 hits
PF00435 Spectrin, 17 hits
PIRSFiPIRSF002297 Spectrin_beta_subunit, 1 hit
SMARTiView protein in SMART
SM00033 CH, 2 hits
SM00150 SPEC, 17 hits
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P11277-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTSATEFENV GNQPPYSRIN ARWDAPDDEL DNDNSSARLF ERSRIKALAD 
        60         70         80         90        100
EREVVQKKTF TKWVNSHLAR VSCRITDLYK DLRDGRMLIK LLEVLSGEML 
       110        120        130        140        150
PKPTKGKMRI HCLENVDKAL QFLKEQRVHL ENMGSHDIVD GNHRLVLGLI 
       160        170        180        190        200
WTIILRFQIQ DIVVQTQEGR ETRSAKDALL LWCQMKTAGY PHVNVTNFTS 
       210        220        230        240        250
SWKDGLAFNA LIHKHRPDLI DFDKLKDSNA RHNLEHAFNV AERQLGIIPL 
       260        270        280        290        300
LDPEDVFTEN PDEKSIITYV VAFYHYFSKM KVLAVEGKRV GKVIDHAIET 
       310        320        330        340        350
EKMIEKYSGL ASDLLTWIEQ TITVLNSRKF ANSLTGVQQQ LQAFSTYRTV 
       360        370        380        390        400
EKPPKFQEKG NLEVLLFTIQ SRMRANNQKV YTPHDGKLVS DINRAWESLE 
       410        420        430        440        450
EAEYRRELAL RNELIRQEKL EQLARRFDRK AAMRETWLSE NQRLVAQDNF 
       460        470        480        490        500
GYDLAAVEAA KKKHEAIETD TAAYEERVRA LEDLAQELEK ENYHDQKRIT 
       510        520        530        540        550
ARKDNILRLW SYLQELLQSR RQRLETTLAL QKLFQDMLHS IDWMDEIKAH 
       560        570        580        590        600
LLSAEFGKHL LEVEDLLQKH KLMEADIAIQ GDKVKAITAA TLKFTEGKGY 
       610        620        630        640        650
QPCDPQVIQD RISHLEQCFE ELSNMAAGRK AQLEQSKRLW KFFWEMDEAE 
       660        670        680        690        700
SWIKEKEQIY SSLDYGKDLT SVLILQRKHK AFEDELRGLD AHLEQIFQEA 
       710        720        730        740        750
HGMVARKQFG HPQIEARIKE VSAQWDQLKD LAAFCKKNLQ DAENFFQFQG 
       760        770        780        790        800
DADDLKAWLQ DAHRLLSGED VGQDEGATRA LGKKHKDFLE ELEESRGVME 
       810        820        830        840        850
HLEQQAQGFP EEFRDSPDVT HRLQALRELY QQVVAQADLR QQRLQEALDL 
       860        870        880        890        900
YTVFGETDAC ELWMGEKEKW LAEMEMPDTL EDLEVVQHRF DILDQEMKTL 
       910        920        930        940        950
MTQIDGVNLA ANSLVESGHP RSREVKQYQD HLNTRWQAFQ TLVSERREAV 
       960        970        980        990       1000
DSALRVHNYC VDCEETSKWI TDKTKVVEST KDLGRDLAGI IAIQRKLSGL 
      1010       1020       1030       1040       1050
ERDVAAIQAR VDALERESQQ LMDSHPEQKE DIGQRQKHLE ELWQGLQQSL 
      1060       1070       1080       1090       1100
QGQEDLLGEV SQLQAFLQDL DDFQAWLSIT QKAVASEDMP ESLPEAEQLL 
      1110       1120       1130       1140       1150
QQHAGIKDEI DGHQDSYQRV KESGEKVIQG QTDPEYLLLG QRLEGLDTGW 
      1160       1170       1180       1190       1200
NALGRMWESR SHTLAQCLGF QEFQKDAKQA EAILSNQEYT LAHLEPPDSL 
      1210       1220       1230       1240       1250
EAAEAGIRKF EDFLGSMENN RDKVLSPVDS GNKLVAEGNL YSDKIKEKVQ 
      1260       1270       1280       1290       1300
LIEDRHRKNN EKAQEASVLL RDNLELQNFL QNCQELTLWI NDKLLTSQDV 
      1310       1320       1330       1340       1350
SYDEARNLHN KWLKHQAFVA ELASHEGWLE NIDAEGKQLM DEKPQFTALV 
      1360       1370       1380       1390       1400
SQKLEALHRL WDELQATTKE KTQHLSAARS SDLRLQTHAD LNKWISAMED 
      1410       1420       1430       1440       1450
QLRSDDPGKD LTSVNRMLAK LKRVEDQVNV RKEELGELFA QVPSMGEEGG 
      1460       1470       1480       1490       1500
DADLSIEKRF LDLLEPLGRR KKQLESSRAK LQISRDLEDE TLWVEERLPL 
      1510       1520       1530       1540       1550
AQSADYGTNL QTVQLFMKKN QTLQNEILGH TPRVEDVLQR GQQLVEAAEI 
      1560       1570       1580       1590       1600
DCQDLEERLG HLQSSWDRLR EAAAGRLQRL RDANEAQQYY LDADEAEAWI 
      1610       1620       1630       1640       1650
GEQELYVISD EIPKDEEGAI VMLKRHLRQQ RAVEDYGRNI KQLASRAQGL 
      1660       1670       1680       1690       1700
LSAGHPEGEQ IIRLQGQVDK HYAGLKDVAE ERKRKLENMY HLFQLKRETD 
      1710       1720       1730       1740       1750
DLEQWISEKE LVASSPEMGQ DFDHVTLLRD KFRDFARETG AIGQERVDNV 
      1760       1770       1780       1790       1800
NAFIERLIDA GHSEAATIAE WKDGLNEMWA DLLELIDTRM QLLAASYDLH 
      1810       1820       1830       1840       1850
RYFYTGAEIL GLIDEKHREL PEDVGLDAST AESFHRVHTA FERELHLLGV 
      1860       1870       1880       1890       1900
QVQQFQDVAT RLQTAYAGEK AEAIQNKEQE VSAAWQALLD ACAGRRTQLV 
      1910       1920       1930       1940       1950
DTADKFRFFS MARDLLSWME SIIRQIETQE RPRDVSSVEL LMKYHQGINA 
      1960       1970       1980       1990       2000
EIETRSKNFS ACLELGESLL QRQHQASEEI REKLQQVMSR RKEMNEKWEA 
      2010       2020       2030       2040       2050
RWERLRMLLE VCQFSRDASV AEAWLIAQEP YLASGDFGHT VDSVEKLIKR 
      2060       2070       2080       2090       2100
HEAFEKSTAS WAERFAALEK PTTLELKERQ IAERPAEETG PQEEEGETAG 
      2110       2120       2130 
EAPVSHHAAT ERTSPVSLWS RLSSSWESLQ PEPSHPY
Length:2,137
Mass (Da):246,468
Last modified:November 25, 2008 - v5
Checksum:i311AE5CD53237610
GO
Isoform 2 (identifier: P11277-2) [UniParc]FASTAAdd to basket
Also known as: Muscle-specific

The sequence of this isoform differs from the canonical sequence as follows:
     2116-2137: VSLWSRLSSSWESLQPEPSHPY → GEEEGTWPQN...KRFSFFPKKK

Show »
Length:2,328
Mass (Da):267,826
Checksum:i5C3709E99F70B8D0
GO
Isoform 3 (identifier: P11277-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2074-2137: LELKERQIAE...SLQPEPSHPY → ASRGGRRDSRGGSSFPPCGHRENVPGQSLVSFV

Note: Due to exon skipping.
Show »
Length:2,106
Mass (Da):242,802
Checksum:iE48305033176AE98
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YJE6H0YJE6_HUMAN
Spectrin beta chain, erythrocytic
SPTB
1,028Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti403E → G in AAA60578 (PubMed:2195026).Curated1
Sequence conflicti403E → G in AAA60579 (PubMed:2195026).Curated1
Sequence conflicti612I → M in AAA60578 (PubMed:2195026).Curated1
Sequence conflicti612I → M in AAA60579 (PubMed:2195026).Curated1
Sequence conflicti629 – 631RKA → ART in AAA60578 (PubMed:2195026).Curated3
Sequence conflicti629 – 631RKA → ART in AAA60579 (PubMed:2195026).Curated3
Sequence conflicti958 – 959NY → TL in AAA60578 (PubMed:2195026).Curated2
Sequence conflicti958 – 959NY → TL in AAA60579 (PubMed:2195026).Curated2
Sequence conflicti1031D → N in AAA60578 (PubMed:2195026).Curated1
Sequence conflicti1031D → N in AAA60579 (PubMed:2195026).Curated1
Sequence conflicti1844 – 1845EL → DV in AAA60578 (PubMed:2195026).Curated2
Sequence conflicti1844 – 1845EL → DV in AAA60579 (PubMed:2195026).Curated2
Sequence conflicti1844 – 1845EL → DV in AAA63259 (PubMed:2056132).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_001352202W → R in SPH2; spectrin Kissimmee. 1 PublicationCorresponds to variant dbSNP:rs121918646EnsemblClinVar.1
Natural variantiVAR_001353439S → N1 PublicationCorresponds to variant dbSNP:rs229587EnsemblClinVar.1
Natural variantiVAR_061084525E → K. Corresponds to variant dbSNP:rs55752508Ensembl.1
Natural variantiVAR_038514613S → I. Corresponds to variant dbSNP:rs3742601EnsemblClinVar.1
Natural variantiVAR_0013541151N → D3 PublicationsCorresponds to variant dbSNP:rs77806EnsemblClinVar.1
Natural variantiVAR_0013551374H → R1 PublicationCorresponds to variant dbSNP:rs10132778EnsemblClinVar.1
Natural variantiVAR_0013561403R → Q. Corresponds to variant dbSNP:rs17180350EnsemblClinVar.1
Natural variantiVAR_0385151408G → R. Corresponds to variant dbSNP:rs17245552EnsemblClinVar.1
Natural variantiVAR_0013572018A → G in EL3; Cagliary. 1 PublicationCorresponds to variant dbSNP:rs121918647EnsemblClinVar.1
Natural variantiVAR_0013582019S → P in EL3; Providence. 1 PublicationCorresponds to variant dbSNP:rs121918648EnsemblClinVar.1
Natural variantiVAR_0013592023A → V in EL3; Paris. 1 PublicationCorresponds to variant dbSNP:rs367841692Ensembl.1
Natural variantiVAR_0013602024W → R in EL3; Linguere. 1 PublicationCorresponds to variant dbSNP:rs1225539653Ensembl.1
Natural variantiVAR_0013612025L → R in EL3; Buffalo. Corresponds to variant dbSNP:rs121918649EnsemblClinVar.1
Natural variantiVAR_0013622053A → P in EL3; Kayes. 1 PublicationCorresponds to variant dbSNP:rs121918645EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0072422074 – 2137LELKE…PSHPY → ASRGGRRDSRGGSSFPPCGH RENVPGQSLVSFV in isoform 3. 1 PublicationAdd BLAST64
Alternative sequenceiVSP_0007192116 – 2137VSLWS…PSHPY → GEEEGTWPQNLQQPPPPGQH KDGQKSTGDERPTTEPLFKV LDTPLSEGDEPATLPAPRDH GQSVQMEGYLGRKHDLEGPN KKASNRSWNNLYCVLRNSEL TFYKDAKNLALGMPYHGEEP LALRHAICEIAANYKKKKHV FKLRLSNGSEWLFHGKDEEE MLSWLQGVSTAINESQSIRV KAQSLPLPSLSGPDASLGKK DKEKRFSFFPKKK in isoform 2. 1 PublicationAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05500 mRNA Translation: AAA60578.1
J05500 mRNA Translation: AAA60579.1
AL121774 Genomic DNA No translation available.
M37884 mRNA Translation: AAA63259.1
M37885 mRNA Translation: AAA60571.1
M57948 mRNA No translation available.
X59510 mRNA Translation: CAA42097.1
X59511 mRNA Translation: CAA42098.1
M18054 mRNA Translation: AAA60572.1
CCDSiCCDS32099.1 [P11277-2]
CCDS32100.1 [P11277-1]
PIRiA37064 SJHUB
RefSeqiNP_000338.3, NM_000347.5
NP_001020029.1, NM_001024858.2 [P11277-2]
XP_005268080.1, XM_005268023.4
XP_016877101.1, XM_017021612.1 [P11277-2]
XP_016877103.1, XM_017021614.1
UniGeneiHs.417303

Genome annotation databases

EnsembliENST00000389720; ENSP00000374370; ENSG00000070182 [P11277-1]
ENST00000389721; ENSP00000374371; ENSG00000070182 [P11277-1]
ENST00000389722; ENSP00000374372; ENSG00000070182 [P11277-2]
ENST00000556626; ENSP00000451752; ENSG00000070182 [P11277-2]
ENST00000644917; ENSP00000495909; ENSG00000070182 [P11277-2]
GeneIDi6710
KEGGihsa:6710
UCSCiuc001xhr.4 human [P11277-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05500 mRNA Translation: AAA60578.1
J05500 mRNA Translation: AAA60579.1
AL121774 Genomic DNA No translation available.
M37884 mRNA Translation: AAA63259.1
M37885 mRNA Translation: AAA60571.1
M57948 mRNA No translation available.
X59510 mRNA Translation: CAA42097.1
X59511 mRNA Translation: CAA42098.1
M18054 mRNA Translation: AAA60572.1
CCDSiCCDS32099.1 [P11277-2]
CCDS32100.1 [P11277-1]
PIRiA37064 SJHUB
RefSeqiNP_000338.3, NM_000347.5
NP_001020029.1, NM_001024858.2 [P11277-2]
XP_005268080.1, XM_005268023.4
XP_016877101.1, XM_017021612.1 [P11277-2]
XP_016877103.1, XM_017021614.1
UniGeneiHs.417303

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1S35X-ray2.40A1063-1275[»]
3EDUX-ray2.10A1692-1907[»]
3F57X-ray2.90A/B1686-1907[»]
3KBTX-ray2.75A/B1583-1906[»]
3KBUX-ray2.75A/B1583-1906[»]
3LBXX-ray2.80B1902-2084[»]
ProteinModelPortaliP11277
SMRiP11277
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112588, 27 interactors
DIPiDIP-1021N
IntActiP11277, 10 interactors
STRINGi9606.ENSP00000374372

PTM databases

CarbonylDBiP11277
iPTMnetiP11277
PhosphoSitePlusiP11277

Polymorphism and mutation databases

BioMutaiSPTB
DMDMi215274269

2D gel databases

SWISS-2DPAGEiP11277

Proteomic databases

EPDiP11277
MaxQBiP11277
PaxDbiP11277
PeptideAtlasiP11277
PRIDEiP11277
ProteomicsDBi52731
52732 [P11277-2]
52733 [P11277-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000389720; ENSP00000374370; ENSG00000070182 [P11277-1]
ENST00000389721; ENSP00000374371; ENSG00000070182 [P11277-1]
ENST00000389722; ENSP00000374372; ENSG00000070182 [P11277-2]
ENST00000556626; ENSP00000451752; ENSG00000070182 [P11277-2]
ENST00000644917; ENSP00000495909; ENSG00000070182 [P11277-2]
GeneIDi6710
KEGGihsa:6710
UCSCiuc001xhr.4 human [P11277-1]

Organism-specific databases

CTDi6710
DisGeNETi6710
EuPathDBiHostDB:ENSG00000070182.17
GeneCardsiSPTB
HGNCiHGNC:11274 SPTB
HPAiCAB015169
CAB016232
HPA003394
HPA003398
MalaCardsiSPTB
MIMi182870 gene
616649 phenotype
617948 phenotype
neXtProtiNX_P11277
OpenTargetsiENSG00000070182
Orphaneti288 Hereditary elliptocytosis
822 Hereditary spherocytosis
PharmGKBiPA36103
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0517 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00760000118813
HOGENOMiHOG000007281
HOVERGENiHBG057912
InParanoidiP11277
KOiK06115
OMAiHRMHAAF
OrthoDBiEOG091G003V
PhylomeDBiP11277
TreeFamiTF313446

Enzyme and pathway databases

ReactomeiR-HSA-375165 NCAM signaling for neurite out-growth
R-HSA-445095 Interaction between L1 and Ankyrins
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6807878 COPI-mediated anterograde transport

Miscellaneous databases

ChiTaRSiSPTB human
EvolutionaryTraceiP11277
GeneWikiiSPTB
GenomeRNAii6710
PROiPR:P11277
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000070182 Expressed in 165 organ(s), highest expression level in gastrocnemius
CleanExiHS_SPTB
ExpressionAtlasiP11277 baseline and differential
GenevisibleiP11277 HS

Family and domain databases

CDDicd00014 CH, 2 hits
Gene3Di1.10.418.10, 2 hits
InterProiView protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR018159 Spectrin/alpha-actinin
IPR016343 Spectrin_bsu
IPR002017 Spectrin_repeat
PfamiView protein in Pfam
PF00307 CH, 2 hits
PF00435 Spectrin, 17 hits
PIRSFiPIRSF002297 Spectrin_beta_subunit, 1 hit
SMARTiView protein in SMART
SM00033 CH, 2 hits
SM00150 SPEC, 17 hits
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSPTB1_HUMAN
AccessioniPrimary (citable) accession number: P11277
Secondary accession number(s): Q15510, Q15519
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 25, 2008
Last modified: November 7, 2018
This is version 198 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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