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Entry version 223 (13 Feb 2019)
Sequence version 2 (03 Apr 2007)
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Protein

Breakpoint cluster region protein

Gene

BCR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation, Guanine-nucleotide releasing factor, Kinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants
R-HSA-194840 Rho GTPase cycle
R-HSA-5655302 Signaling by FGFR1 in disease

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P11274

SIGNOR Signaling Network Open Resource

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SIGNORi
P11274

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Breakpoint cluster region protein (EC:2.7.11.1)
Alternative name(s):
Renal carcinoma antigen NY-REN-26
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BCR
Synonyms:BCR1, D22S11
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000186716.19

Human Gene Nomenclature Database

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HGNCi
HGNC:1014 BCR

Online Mendelian Inheritance in Man (OMIM)

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MIMi
151410 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P11274

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Leukemia, chronic myeloid (CML)3 Publications
The gene represented in this entry is involved in disease pathogenesis.
Disease descriptionA clonal myeloproliferative disorder of a pluripotent stem cell with a specific cytogenetic abnormality, the Philadelphia chromosome (Ph), involving myeloid, erythroid, megakaryocytic, B-lymphoid, and sometimes T-lymphoid cells, but not marrow fibroblasts.
See also OMIM:608232
A chromosomal aberration involving BCR has been found in patients with chronic myeloid leukemia. Translocation t(9;22)(q34;q11) with ABL1. The translocation produces a BCR-ABL found also in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi177Y → F: Abolishes interaction with FES and GRB2. 2 Publications1
Mutagenesisi1269 – 1271Missing : Abolishes interaction with PDZK1. 1 Publication3
Mutagenesisi1271V → A: Reduces interaction with PDZK1. 1 Publication1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei426 – 427Breakpoint for translocation to form BCR-ABL oncogene2

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNET

More...
DisGeNETi
613

MalaCards human disease database

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MalaCardsi
BCR
MIMi608232 phenotype

Open Targets

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OpenTargetsi
ENSG00000186716

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
521 Chronic myeloid leukemia
261330 Distal 22q11.2 microdeletion syndrome
99860 Precursor B-cell acute lymphoblastic leukemia
99861 Precursor T-cell acute lymphoblastic leukemia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA25321

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL5146

Drug and drug target database

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DrugBanki
DB06616 Bosutinib
DB08901 Ponatinib

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
BCR

Domain mapping of disease mutations (DMDM)

More...
DMDMi
143811366

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000809331 – 1271Breakpoint cluster region proteinAdd BLAST1271

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei122PhosphoserineCombined sources1
Modified residuei139PhosphoserineCombined sources1
Modified residuei177Phosphotyrosine; by HCKCombined sources1 Publication1
Modified residuei202PhosphoserineCombined sources1
Modified residuei215PhosphoserineCombined sources1
Modified residuei222PhosphoserineCombined sources1
Modified residuei236PhosphoserineBy similarity1
Modified residuei246Phosphotyrosine; by FES1 Publication1
Modified residuei356PhosphoserineCombined sources1
Modified residuei377PhosphoserineCombined sources1
Modified residuei382PhosphoserineBy similarity1
Modified residuei385PhosphothreonineBy similarity1
Modified residuei459PhosphoserineCombined sources1
Modified residuei463PhosphoserineCombined sources1
Modified residuei471Omega-N-methylarginineBy similarity1
Modified residuei473PhosphoserineCombined sources1
Modified residuei488PhosphoserineCombined sources1
Modified residuei554PhosphotyrosineCombined sources1
Modified residuei641PhosphothreonineCombined sources1
Modified residuei644PhosphotyrosineCombined sources1
Modified residuei693PhosphothreonineCombined sources1
Modified residuei894PhosphoserineCombined sources1
Modified residuei1264PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylated. Phosphorylated by FES/FPS on tyrosine residues, leading to down-regulation of the BCR kinase activity. Phosphorylation at Tyr-177 by HCK is important for interaction with GRB2.2 Publications

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P11274

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P11274

MaxQB - The MaxQuant DataBase

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MaxQBi
P11274

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P11274

PeptideAtlas

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PeptideAtlasi
P11274

PRoteomics IDEntifications database

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PRIDEi
P11274

ProteomicsDB human proteome resource

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ProteomicsDBi
52729
52730 [P11274-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P11274

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P11274

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000186716 Expressed in 215 organ(s), highest expression level in adenohypophysis

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P11274 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P11274 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB010421
CAB018545
HPA038337

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer. Interacts with PDZK1. May interact with CCPG1 (By similarity). Interacts with FES/FPS, ABL1, PIK3R1 and GRB2. Interacts with HCK. Interacts with SH2D5 (PubMed:25331951).By similarity5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
107083, 81 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
P11274

Protein interaction database and analysis system

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IntActi
P11274, 35 interactors

Molecular INTeraction database

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MINTi
P11274

STRING: functional protein association networks

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STRINGi
9606.ENSP00000303507

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P11274

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11271
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K1FX-ray2.20A/B/C/D/E/F/G/H1-72[»]
2AINNMR-B1266-1271[»]
5N6RNMR-A487-702[»]
5N7EX-ray1.65B487-702[»]
5OC7X-ray1.65A/D704-893[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P11274

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P11274

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P11274

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini498 – 691DHPROSITE-ProRule annotationAdd BLAST194
Domaini708 – 866PHPROSITE-ProRule annotationAdd BLAST159
Domaini870 – 1002C2PROSITE-ProRule annotationAdd BLAST133
Domaini1054 – 1248Rho-GAPPROSITE-ProRule annotationAdd BLAST195

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 426KinaseAdd BLAST426
Regioni197 – 385Binding to ABL SH2-domainAdd BLAST189

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi824 – 827Poly-Leu4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The region involved in binding to ABL1 SH2-domain is rich in serine residues and needs to be Ser/Thr phosphorylated prior to SH2 binding. This region is essential for the activation of the ABL1 tyrosine kinase and transforming potential of the chimeric BCR-ABL oncogene.
The DH domain is involved in interaction with CCPG1.By similarity

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4269 Eukaryota
ENOG410XPGZ LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153491

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000006779

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG004165

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P11274

KEGG Orthology (KO)

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KOi
K08878

Identification of Orthologs from Complete Genome Data

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OMAi
DRIMGKG

Database of Orthologous Groups

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OrthoDBi
762492at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P11274

TreeFam database of animal gene trees

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TreeFami
TF105082

Family and domain databases

Conserved Domains Database

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CDDi
cd00160 RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.555.10, 1 hit
1.20.900.10, 1 hit
2.60.40.150, 1 hit
4.10.280.30, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR037769 Abr/Bcr
IPR015123 Bcr-Abl_oncoprot_oligo
IPR036481 Bcr-Abl_oncoprot_oligo_sf
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR001849 PH_domain
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom

The PANTHER Classification System

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PANTHERi
PTHR23182 PTHR23182, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF09036 Bcr-Abl_Oligo, 1 hit
PF00168 C2, 1 hit
PF00620 RhoGAP, 1 hit
PF00621 RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00239 C2, 1 hit
SM00233 PH, 1 hit
SM00324 RhoGAP, 1 hit
SM00325 RhoGEF, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48065 SSF48065, 1 hit
SSF48350 SSF48350, 1 hit
SSF69036 SSF69036, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50004 C2, 1 hit
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50238 RHOGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P11274-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVDPVGFAEA WKAQFPDSEP PRMELRSVGD IEQELERCKA SIRRLEQEVN
60 70 80 90 100
QERFRMIYLQ TLLAKEKKSY DRQRWGFRRA AQAPDGASEP RASASRPQPA
110 120 130 140 150
PADGADPPPA EEPEARPDGE GSPGKARPGT ARRPGAAASG ERDDRGPPAS
160 170 180 190 200
VAALRSNFER IRKGHGQPGA DAEKPFYVNV EFHHERGLVK VNDKEVSDRI
210 220 230 240 250
SSLGSQAMQM ERKKSQHGAG SSVGDASRPP YRGRSSESSC GVDGDYEDAE
260 270 280 290 300
LNPRFLKDNL IDANGGSRPP WPPLEYQPYQ SIYVGGMMEG EGKGPLLRSQ
310 320 330 340 350
STSEQEKRLT WPRRSYSPRS FEDCGGGYTP DCSSNENLTS SEEDFSSGQS
360 370 380 390 400
SRVSPSPTTY RMFRDKSRSP SQNSQQSFDS SSPPTPQCHK RHRHCPVVVS
410 420 430 440 450
EATIVGVRKT GQIWPNDGEG AFHGDADGSF GTPPGYGCAA DRAEEQRRHQ
460 470 480 490 500
DGLPYIDDSP SSSPHLSSKG RGSRDALVSG ALESTKASEL DLEKGLEMRK
510 520 530 540 550
WVLSGILASE ETYLSHLEAL LLPMKPLKAA ATTSQPVLTS QQIETIFFKV
560 570 580 590 600
PELYEIHKEF YDGLFPRVQQ WSHQQRVGDL FQKLASQLGV YRAFVDNYGV
610 620 630 640 650
AMEMAEKCCQ ANAQFAEISE NLRARSNKDA KDPTTKNSLE TLLYKPVDRV
660 670 680 690 700
TRSTLVLHDL LKHTPASHPD HPLLQDALRI SQNFLSSINE EITPRRQSMT
710 720 730 740 750
VKKGEHRQLL KDSFMVELVE GARKLRHVFL FTDLLLCTKL KKQSGGKTQQ
760 770 780 790 800
YDCKWYIPLT DLSFQMVDEL EAVPNIPLVP DEELDALKIK ISQIKNDIQR
810 820 830 840 850
EKRANKGSKA TERLKKKLSE QESLLLLMSP SMAFRVHSRN GKSYTFLISS
860 870 880 890 900
DYERAEWREN IREQQKKCFR SFSLTSVELQ MLTNSCVKLQ TVHSIPLTIN
910 920 930 940 950
KEDDESPGLY GFLNVIVHSA TGFKQSSNLY CTLEVDSFGY FVNKAKTRVY
960 970 980 990 1000
RDTAEPNWNE EFEIELEGSQ TLRILCYEKC YNKTKIPKED GESTDRLMGK
1010 1020 1030 1040 1050
GQVQLDPQAL QDRDWQRTVI AMNGIEVKLS VKFNSREFSL KRMPSRKQTG
1060 1070 1080 1090 1100
VFGVKIAVVT KRERSKVPYI VRQCVEEIER RGMEEVGIYR VSGVATDIQA
1110 1120 1130 1140 1150
LKAAFDVNNK DVSVMMSEMD VNAIAGTLKL YFRELPEPLF TDEFYPNFAE
1160 1170 1180 1190 1200
GIALSDPVAK ESCMLNLLLS LPEANLLTFL FLLDHLKRVA EKEAVNKMSL
1210 1220 1230 1240 1250
HNLATVFGPT LLRPSEKESK LPANPSQPIT MTDSWSLEVM SQVQVLLYFL
1260 1270
QLEAIPAPDS KRQSILFSTE V
Length:1,271
Mass (Da):142,819
Last modified:April 3, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4BF66FA1E9D205FE
GO
Isoform 2 (identifier: P11274-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     961-1004: Missing.

Note: No experimental confirmation available.
Show »
Length:1,227
Mass (Da):137,729
Checksum:iEFEE4915DE3FE893
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y554H0Y554_HUMAN
Breakpoint cluster region protein
BCR
257Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAE06073 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti287M → I in CAA68676 (PubMed:3285291).Curated1
Sequence conflicti418G → D in CAA68676 (PubMed:3285291).Curated1
Sequence conflicti483E → K in CAA68676 (PubMed:3285291).Curated1
Sequence conflicti560F → S in CAA68676 (PubMed:3285291).Curated1
Sequence conflicti690E → D (PubMed:2407300).Curated1
Sequence conflicti733D → E in CAA26441 (PubMed:3107980).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_041883400S → P in a bladder transitional cell carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041884413I → M1 PublicationCorresponds to variant dbSNP:rs56321828Ensembl.1
Natural variantiVAR_051983558K → T. Corresponds to variant dbSNP:rs4437065Ensembl.1
Natural variantiVAR_041885752D → E1 PublicationCorresponds to variant dbSNP:rs12484731Ensembl.1
Natural variantiVAR_031552796N → S5 PublicationsCorresponds to variant dbSNP:rs140504Ensembl.1
Natural variantiVAR_041886910Y → C1 PublicationCorresponds to variant dbSNP:rs35537221Ensembl.1
Natural variantiVAR_041887949V → I1 PublicationCorresponds to variant dbSNP:rs2229038EnsemblClinVar.1
Natural variantiVAR_0315531037E → K1 PublicationCorresponds to variant dbSNP:rs776552570Ensembl.1
Natural variantiVAR_0418881091V → M1 PublicationCorresponds to variant dbSNP:rs778229520Ensembl.1
Natural variantiVAR_0418891096T → A1 PublicationCorresponds to variant dbSNP:rs745459086Ensembl.1
Natural variantiVAR_0418901104A → G1 PublicationCorresponds to variant dbSNP:rs11558696Ensembl.1
Natural variantiVAR_0418911106D → N1 PublicationCorresponds to variant dbSNP:rs879255379EnsemblClinVar.1
Natural variantiVAR_0315541127T → M. Corresponds to variant dbSNP:rs35812689Ensembl.1
Natural variantiVAR_0418921149A → T1 PublicationCorresponds to variant dbSNP:rs200099830Ensembl.1
Natural variantiVAR_0418931161E → K1 Publication1
Natural variantiVAR_0418941187K → E1 PublicationCorresponds to variant dbSNP:rs1195127922Ensembl.1
Natural variantiVAR_0418951189V → M1 PublicationCorresponds to variant dbSNP:rs55816482Ensembl.1
Natural variantiVAR_0418961204A → G1 PublicationCorresponds to variant dbSNP:rs56265970Ensembl.1
Natural variantiVAR_0418971235W → R1 PublicationCorresponds to variant dbSNP:rs55719322Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_024352961 – 1004Missing in isoform 2. 1 PublicationAdd BLAST44

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y00661 mRNA Translation: CAA68676.1
U07000 Genomic DNA Translation: AAB60388.1
AB209991 mRNA Translation: BAE06073.1 Different initiation.
X02596 mRNA Translation: CAA26441.1
M15025 Genomic DNA Translation: AAA35594.1
X52828 Genomic DNA Translation: CAA37010.1
X52829 Genomic DNA Translation: CAA37011.1
X14676 mRNA Translation: CAA32806.1
M64437 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13806.1 [P11274-1]
CCDS13807.1 [P11274-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
A26664 TVHUA2
A91064 TVHUBR

NCBI Reference Sequences

More...
RefSeqi
NP_004318.3, NM_004327.3 [P11274-1]
NP_067585.2, NM_021574.2 [P11274-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.517461
Hs.684909
Hs.715409

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000305877; ENSP00000303507; ENSG00000186716 [P11274-1]
ENST00000359540; ENSP00000352535; ENSG00000186716 [P11274-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
613

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:613

UCSC genome browser

More...
UCSCi
uc002zww.4 human [P11274-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00661 mRNA Translation: CAA68676.1
U07000 Genomic DNA Translation: AAB60388.1
AB209991 mRNA Translation: BAE06073.1 Different initiation.
X02596 mRNA Translation: CAA26441.1
M15025 Genomic DNA Translation: AAA35594.1
X52828 Genomic DNA Translation: CAA37010.1
X52829 Genomic DNA Translation: CAA37011.1
X14676 mRNA Translation: CAA32806.1
M64437 mRNA No translation available.
CCDSiCCDS13806.1 [P11274-1]
CCDS13807.1 [P11274-2]
PIRiA26664 TVHUA2
A91064 TVHUBR
RefSeqiNP_004318.3, NM_004327.3 [P11274-1]
NP_067585.2, NM_021574.2 [P11274-2]
UniGeneiHs.517461
Hs.684909
Hs.715409

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K1FX-ray2.20A/B/C/D/E/F/G/H1-72[»]
2AINNMR-B1266-1271[»]
5N6RNMR-A487-702[»]
5N7EX-ray1.65B487-702[»]
5OC7X-ray1.65A/D704-893[»]
ProteinModelPortaliP11274
SMRiP11274
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107083, 81 interactors
ELMiP11274
IntActiP11274, 35 interactors
MINTiP11274
STRINGi9606.ENSP00000303507

Chemistry databases

BindingDBiP11274
ChEMBLiCHEMBL5146
DrugBankiDB06616 Bosutinib
DB08901 Ponatinib

PTM databases

iPTMnetiP11274
PhosphoSitePlusiP11274

Polymorphism and mutation databases

BioMutaiBCR
DMDMi143811366

Proteomic databases

EPDiP11274
jPOSTiP11274
MaxQBiP11274
PaxDbiP11274
PeptideAtlasiP11274
PRIDEiP11274
ProteomicsDBi52729
52730 [P11274-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305877; ENSP00000303507; ENSG00000186716 [P11274-1]
ENST00000359540; ENSP00000352535; ENSG00000186716 [P11274-2]
GeneIDi613
KEGGihsa:613
UCSCiuc002zww.4 human [P11274-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
613
DisGeNETi613
EuPathDBiHostDB:ENSG00000186716.19

GeneCards: human genes, protein and diseases

More...
GeneCardsi
BCR

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0016226
HIX0016271
HIX0027936
HIX0041406
HGNCiHGNC:1014 BCR
HPAiCAB010421
CAB018545
HPA038337
MalaCardsiBCR
MIMi151410 gene
608232 phenotype
neXtProtiNX_P11274
OpenTargetsiENSG00000186716
Orphaneti521 Chronic myeloid leukemia
261330 Distal 22q11.2 microdeletion syndrome
99860 Precursor B-cell acute lymphoblastic leukemia
99861 Precursor T-cell acute lymphoblastic leukemia
PharmGKBiPA25321

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4269 Eukaryota
ENOG410XPGZ LUCA
GeneTreeiENSGT00940000153491
HOGENOMiHOG000006779
HOVERGENiHBG004165
InParanoidiP11274
KOiK08878
OMAiDRIMGKG
OrthoDBi762492at2759
PhylomeDBiP11274
TreeFamiTF105082

Enzyme and pathway databases

ReactomeiR-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants
R-HSA-194840 Rho GTPase cycle
R-HSA-5655302 Signaling by FGFR1 in disease
SignaLinkiP11274
SIGNORiP11274

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
BCR human
EvolutionaryTraceiP11274

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
BCR_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
613

Protein Ontology

More...
PROi
PR:P11274

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000186716 Expressed in 215 organ(s), highest expression level in adenohypophysis
ExpressionAtlasiP11274 baseline and differential
GenevisibleiP11274 HS

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
Gene3Di1.10.555.10, 1 hit
1.20.900.10, 1 hit
2.60.40.150, 1 hit
4.10.280.30, 1 hit
InterProiView protein in InterPro
IPR037769 Abr/Bcr
IPR015123 Bcr-Abl_oncoprot_oligo
IPR036481 Bcr-Abl_oncoprot_oligo_sf
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR001849 PH_domain
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
PANTHERiPTHR23182 PTHR23182, 1 hit
PfamiView protein in Pfam
PF09036 Bcr-Abl_Oligo, 1 hit
PF00168 C2, 1 hit
PF00620 RhoGAP, 1 hit
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00233 PH, 1 hit
SM00324 RhoGAP, 1 hit
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
SSF48350 SSF48350, 1 hit
SSF69036 SSF69036, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50238 RHOGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBCR_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P11274
Secondary accession number(s): P78501
, Q12842, Q4LE80, Q6NZI3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: April 3, 2007
Last modified: February 13, 2019
This is version 223 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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