NAT2

Functionⁱ

Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.

Catalytic activityⁱ

Acetyl-CoA + an arylamine = CoA + an N-acetylarylamine.

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	68	Acyl-thioester intermediate	1
Binding siteⁱ	103	Coenzyme A1 Publication	1
Binding siteⁱ	104	Coenzyme A; via amide nitrogen1 Publication	1
Active siteⁱ	107		1
Active siteⁱ	122		1
Binding siteⁱ	208	Coenzyme A1 Publication	1
Binding siteⁱ	214	Coenzyme A1 Publication	1
Binding siteⁱ	287	Coenzyme A1 Publication	1

GO - Molecular functionⁱ

arylamine N-acetyltransferase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

xenobiotic metabolic process Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Acyltransferase, Transferase

Molecular function

Acyltransferase, Transferase

Enzyme and pathway databases

BRENDAⁱ	2.3.1.5 2681
Reactomeⁱ	R-HSA-156582 Acetylation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Arylamine N-acetyltransferase 2 (EC:2.3.1.5) Alternative name(s): Arylamide acetylase 2 N-acetyltransferase type 2 Short name: NAT-2 Polymorphic arylamine N-acetyltransferase Short name: PNAT
Gene namesⁱ	Name:NAT2 Synonyms:AAC2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 8

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000156006.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7646 NAT2
MIMⁱ	612182 gene
neXtProtⁱ	NX_P11245

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10
MalaCards human disease database More...MalaCardsⁱ	NAT2
MIMⁱ	243400 phenotype
Orphanetⁱ	240887 Isoniazid toxicity
PharmGKBⁱ	PA18

Chemistry databases

ChEMBLⁱ	CHEMBL2194
Drug and drug target database More...DrugBankⁱ	DB00316 Acetaminophen DB01068 Clonazepam DB00250 Dapsone DB04953 Ezogabine DB00951 Isoniazid DB01015 Sulfamethoxazole

Polymorphism and mutation databases

BioMutaⁱ	NAT2
DMDMⁱ	114238

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000107905	1 – 290	Arylamine N-acetyltransferase 2Add BLAST		290

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P11245
PaxDbⁱ	P11245
PeptideAtlas More...PeptideAtlasⁱ	P11245
PRIDEⁱ	P11245
ProteomicsDBⁱ	52728

PTM databases

iPTMnetⁱ	P11245
PhosphoSitePlusⁱ	P11245

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000156006 Expressed in 83 organ(s), highest expression level in liver
CleanExⁱ	HS_NAT2
ExpressionAtlasⁱ	P11245 baseline and differential
Genevisibleⁱ	P11245 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA043704

HPAⁱ

HPA043704

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
ATM	Q13315	2	EBI-9057228,EBI-495465
RAD51	Q06609	4	EBI-9057228,EBI-297202

Protein-protein interaction databases

BioGridⁱ	106528, 20 interactors
IntActⁱ	P11245, 19 interactors
Molecular INTeraction database More...MINTⁱ	P11245
STRINGⁱ	9606.ENSP00000286479

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	2 – 9	Combined sources	8
Helixⁱ	21 – 34	Combined sources	14
Helixⁱ	40 – 43	Combined sources	4
Helixⁱ	52 – 59	Combined sources	8
Helixⁱ	68 – 82	Combined sources	15
Beta strandⁱ	85 – 95	Combined sources	11
Helixⁱ	96 – 98	Combined sources	3
Beta strandⁱ	107 – 114	Combined sources	8
Beta strandⁱ	117 – 121	Combined sources	5
Helixⁱ	127 – 129	Combined sources	3
Beta strandⁱ	142 – 144	Combined sources	3
Beta strandⁱ	149 – 155	Combined sources	7
Beta strandⁱ	158 – 164	Combined sources	7
Beta strandⁱ	167 – 171	Combined sources	5
Helixⁱ	173 – 175	Combined sources	3
Beta strandⁱ	185 – 192	Combined sources	8
Helixⁱ	199 – 202	Combined sources	4
Helixⁱ	203 – 211	Combined sources	9
Helixⁱ	216 – 219	Combined sources	4
Beta strandⁱ	222 – 226	Combined sources	5
Beta strandⁱ	228 – 235	Combined sources	8
Beta strandⁱ	238 – 247	Combined sources	10
Beta strandⁱ	250 – 257	Combined sources	8
Helixⁱ	260 – 269	Combined sources	10
Beta strandⁱ	285 – 288	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	P11245
SMRⁱ	P11245
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P11245

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	106 – 107	Substrate bindingCurated		2

Sequence similaritiesⁱ

Belongs to the arylamine N-acetyltransferase family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IFD6 Eukaryota COG2162 LUCA
HOVERGENⁱ	HBG000165
InParanoidⁱ	P11245
KEGG Orthology (KO) More...KOⁱ	K00622
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0CO6
PhylomeDBⁱ	P11245
TreeFamⁱ	TF106311

Family and domain databases

InterProⁱ	View protein in InterPro IPR001447 Arylamine_N-AcTrfase IPR038765 Papain_like_cys_pep_sf
PANTHERⁱ	PTHR11786 PTHR11786, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00797 Acetyltransf_2, 1 hit
PRINTSⁱ	PR01543 ANATRNSFRASE
SUPFAMⁱ	SSF54001 SSF54001, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P11245-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDIEAYFERI GYKNSRNKLD LETLTDILEH QIRAVPFENL NMHCGQAMEL 
        60         70         80         90        100
GLEAIFDHIV RRNRGGWCLQ VNQLLYWALT TIGFQTTMLG GYFYIPPVNK 
       110        120        130        140        150
YSTGMVHLLL QVTIDGRNYI VDAGSGSSSQ MWQPLELISG KDQPQVPCIF 
       160        170        180        190        200
CLTEERGIWY LDQIRREQYI TNKEFLNSHL LPKKKHQKIY LFTLEPRTIE 
       210        220        230        240        250
DFESMNTYLQ TSPTSSFITT SFCSLQTPEG VYCLVGFILT YRKFNYKDNT 
       260        270        280        290
DLVEFKTLTE EEVEEVLKNI FKISLGRNLV PKPGDGSLTI

Length:290

Mass (Da):33,542

Last modified:July 1, 1989 - v1

Checksum:ⁱ63EE3BC2107F12B9

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	E7EWF9	E7EWF9_HUMAN		Arylamine N-acetyltransferase 2 Arylamine N-acetyltransferase 2	NAT2	160	Annotation score:

Sequence cautionⁱ

The sequence AAK51711 differs from that shown. Reason: Frameshift at position 287.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	6	Y → D in CAG28559 (Ref. 13) Curated	1
Sequence conflictⁱ	30	H → T AA sequence (PubMed:2924904).Curated	1
Sequence conflictⁱ	286	G → R in AAG34181 (Ref. 9) Curated	1

Polymorphismⁱ

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_018853	24	L → I2 PublicationsCorresponds to variant dbSNP:rs45477599Ensembl.	1
Natural variantⁱVAR_004608	64	R → Q in allele NAT214A, allele NAT214B, allele NAT214C, allele NAT214D, allele NAT214E, allele NAT214F and allele NAT2*14G; a slow acetylator. 4 PublicationsCorresponds to variant dbSNP:rs1801279EnsemblClinVar.	1
Natural variantⁱVAR_009075	64	R → W in allele NAT2*19. Corresponds to variant dbSNP:rs1805158Ensembl.	1
Natural variantⁱVAR_004609	114	I → T in allele NAT25A, allele NAT25B, allele NAT25C, allele NAT25D, allele NAT25E, allele NAT25F, allele NAT214B and allele NAT214E; a slow acetylator. 8 PublicationsCorresponds to variant dbSNP:rs1801280EnsemblClinVar.	1
Natural variantⁱVAR_020385	122	D → N1 PublicationCorresponds to variant dbSNP:rs4986996Ensembl.	1
Natural variantⁱVAR_046905	135	L → V. Corresponds to variant dbSNP:rs12720065Ensembl.	1
Natural variantⁱVAR_020386	137	L → F1 PublicationCorresponds to variant dbSNP:rs4986997Ensembl.	1
Natural variantⁱVAR_009076	145	Q → P in allele NAT2*17. 1 Publication	1
Natural variantⁱVAR_028781	193	T → M1 Publication	1
Natural variantⁱVAR_004610	197	R → Q in allele NAT25E, allele NAT26A, allele NAT26B, allele NAT26C, allele NAT26D and allele NAT214D; a slow acetylator. 5 PublicationsCorresponds to variant dbSNP:rs1799930EnsemblClinVar.	1
Natural variantⁱVAR_028782	208	Y → H1 PublicationCorresponds to variant dbSNP:rs56387565Ensembl.	1
Natural variantⁱVAR_018854	228	P → L1 PublicationCorresponds to variant dbSNP:rs45518335Ensembl.	1
Natural variantⁱVAR_004611	268	K → R in allele NAT25B, allele NAT25C, allele NAT25F, allele NAT26C, allele NAT212A, allele NAT214B, allele NAT214C, allele NAT214E, allele NAT214F and allele NAT214G. 8 PublicationsCorresponds to variant dbSNP:rs1208Ensembl.	1
Natural variantⁱVAR_061368	280	V → M. Corresponds to variant dbSNP:rs56393504Ensembl.	1
Natural variantⁱVAR_009077	282	K → T in allele NAT2*18. 1 PublicationCorresponds to variant dbSNP:rs56054745Ensembl.	1
Natural variantⁱVAR_004612	286	G → E in allele NAT27A and allele NAT27B; a slow acetylator. 4 PublicationsCorresponds to variant dbSNP:rs1799931EnsemblClinVar.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X14672 Genomic DNA Translation: CAA32802.1 D90040 mRNA Translation: BAA14094.1 D90042 mRNA Translation: BAA14096.1 D10870 Genomic DNA Translation: BAA01640.1 D10871 Genomic DNA Translation: BAA01641.1 D10872 Genomic DNA Translation: BAA01642.1 U23052 Genomic DNA Translation: AAA64584.1 U23434 Genomic DNA Translation: AAA64585.1 DQ305496 Genomic DNA Translation: ABC26032.1 DQ305497 Genomic DNA Translation: ABC26033.1 DQ305498 Genomic DNA Translation: ABC26034.1 DQ305499 Genomic DNA Translation: ABC26035.1 DQ305500 Genomic DNA Translation: ABC26036.1 DQ305501 Genomic DNA Translation: ABC26037.1 DQ305502 Genomic DNA Translation: ABC26038.1 DQ305503 Genomic DNA Translation: ABC26039.1 DQ305504 Genomic DNA Translation: ABC26040.1 DQ305505 Genomic DNA Translation: ABC26041.1 DQ305506 Genomic DNA Translation: ABC26042.1 DQ305507 Genomic DNA Translation: ABC26043.1 DQ305508 Genomic DNA Translation: ABC26044.1 DQ305509 Genomic DNA Translation: ABC26045.1 DQ305510 Genomic DNA Translation: ABC26046.1 DQ305511 Genomic DNA Translation: ABC26047.1 DQ305512 Genomic DNA Translation: ABC26048.1 DQ305513 Genomic DNA Translation: ABC26049.1 DQ305514 Genomic DNA Translation: ABC26050.1 DQ305515 Genomic DNA Translation: ABC26051.1 DQ305516 Genomic DNA Translation: ABC26052.1 DQ305517 Genomic DNA Translation: ABC26053.1 DQ305518 Genomic DNA Translation: ABC26054.1 DQ305519 Genomic DNA Translation: ABC26055.1 DQ305520 Genomic DNA Translation: ABC26056.1 DQ305521 Genomic DNA Translation: ABC26057.1 DQ305522 Genomic DNA Translation: ABC26058.1 DQ305523 Genomic DNA Translation: ABC26059.1 DQ305524 Genomic DNA Translation: ABC26060.1 DQ305525 Genomic DNA Translation: ABC26061.1 DQ305526 Genomic DNA Translation: ABC26062.1 DQ305527 Genomic DNA Translation: ABC26063.1 DQ305528 Genomic DNA Translation: ABC26064.1 DQ305529 Genomic DNA Translation: ABC26065.1 DQ305530 Genomic DNA Translation: ABC26066.1 DQ305531 Genomic DNA Translation: ABC26067.1 DQ305532 Genomic DNA Translation: ABC26068.1 DQ305533 Genomic DNA Translation: ABC26069.1 DQ305534 Genomic DNA Translation: ABC26070.1 DQ305535 Genomic DNA Translation: ABC26071.1 DQ305536 Genomic DNA Translation: ABC26072.1 DQ305537 Genomic DNA Translation: ABC26073.1 DQ305538 Genomic DNA Translation: ABC26074.1 DQ305539 Genomic DNA Translation: ABC26075.1 DQ305540 Genomic DNA Translation: ABC26076.1 DQ305541 Genomic DNA Translation: ABC26077.1 DQ305542 Genomic DNA Translation: ABC26078.1 DQ305543 Genomic DNA Translation: ABC26079.1 DQ305544 Genomic DNA Translation: ABC26080.1 DQ305545 Genomic DNA Translation: ABC26081.1 DQ305546 Genomic DNA Translation: ABC26082.1 DQ305547 Genomic DNA Translation: ABC26083.1 DQ305548 Genomic DNA Translation: ABC26084.1 DQ305549 Genomic DNA Translation: ABC26085.1 DQ305550 Genomic DNA Translation: ABC26086.1 DQ305551 Genomic DNA Translation: ABC26087.1 DQ305552 Genomic DNA Translation: ABC26088.1 DQ305553 Genomic DNA Translation: ABC26089.1 DQ305554 Genomic DNA Translation: ABC26090.1 DQ305555 Genomic DNA Translation: ABC26091.1 DQ305556 Genomic DNA Translation: ABC26092.1 DQ305557 Genomic DNA Translation: ABC26093.1 DQ305558 Genomic DNA Translation: ABC26094.1 DQ305559 Genomic DNA Translation: ABC26095.1 DQ305560 Genomic DNA Translation: ABC26096.1 DQ305561 Genomic DNA Translation: ABC26097.1 DQ305562 Genomic DNA Translation: ABC26098.1 DQ305563 Genomic DNA Translation: ABC26099.1 DQ305564 Genomic DNA Translation: ABC26100.1 DQ305565 Genomic DNA Translation: ABC26101.1 DQ305566 Genomic DNA Translation: ABC26102.1 DQ305567 Genomic DNA Translation: ABC26103.1 DQ305568 Genomic DNA Translation: ABC26104.1 DQ305569 Genomic DNA Translation: ABC26105.1 DQ305570 Genomic DNA Translation: ABC26106.1 DQ305571 Genomic DNA Translation: ABC26107.1 DQ305572 Genomic DNA Translation: ABC26108.1 DQ305573 Genomic DNA Translation: ABC26109.1 DQ305574 Genomic DNA Translation: ABC26110.1 DQ305575 Genomic DNA Translation: ABC26111.1 DQ305576 Genomic DNA Translation: ABC26112.1 DQ305577 Genomic DNA Translation: ABC26113.1 DQ305578 Genomic DNA Translation: ABC26114.1 DQ305579 Genomic DNA Translation: ABC26115.1 DQ305580 Genomic DNA Translation: ABC26116.1 DQ305581 Genomic DNA Translation: ABC26117.1 DQ305582 Genomic DNA Translation: ABC26118.1 DQ305583 Genomic DNA Translation: ABC26119.1 DQ305584 Genomic DNA Translation: ABC26120.1 DQ305585 Genomic DNA Translation: ABC26121.1 DQ305586 Genomic DNA Translation: ABC26122.1 DQ305587 Genomic DNA Translation: ABC26123.1 DQ305588 Genomic DNA Translation: ABC26124.1 DQ305589 Genomic DNA Translation: ABC26125.1 DQ305590 Genomic DNA Translation: ABC26126.1 DQ305591 Genomic DNA Translation: ABC26127.1 DQ305592 Genomic DNA Translation: ABC26128.1 DQ305593 Genomic DNA Translation: ABC26129.1 DQ305594 Genomic DNA Translation: ABC26130.1 DQ305595 Genomic DNA Translation: ABC26131.1 DQ305596 Genomic DNA Translation: ABC26132.1 DQ305597 Genomic DNA Translation: ABC26133.1 DQ305598 Genomic DNA Translation: ABC26134.1 DQ305599 Genomic DNA Translation: ABC26135.1 DQ305600 Genomic DNA Translation: ABC26136.1 DQ305601 Genomic DNA Translation: ABC26137.1 DQ305602 Genomic DNA Translation: ABC26138.1 DQ305603 Genomic DNA Translation: ABC26139.1 DQ305604 Genomic DNA Translation: ABC26140.1 DQ305605 Genomic DNA Translation: ABC26141.1 DQ305606 Genomic DNA Translation: ABC26142.1 DQ305607 Genomic DNA Translation: ABC26143.1 DQ305608 Genomic DNA Translation: ABC26144.1 DQ305609 Genomic DNA Translation: ABC26145.1 DQ305610 Genomic DNA Translation: ABC26146.1 DQ305611 Genomic DNA Translation: ABC26147.1 DQ305612 Genomic DNA Translation: ABC26148.1 DQ305613 Genomic DNA Translation: ABC26149.1 DQ305614 Genomic DNA Translation: ABC26150.1 DQ305615 Genomic DNA Translation: ABC26151.1 DQ305616 Genomic DNA Translation: ABC26152.1 DQ305617 Genomic DNA Translation: ABC26153.1 DQ305618 Genomic DNA Translation: ABC26154.1 DQ305619 Genomic DNA Translation: ABC26155.1 DQ305620 Genomic DNA Translation: ABC26156.1 DQ305621 Genomic DNA Translation: ABC26157.1 DQ305622 Genomic DNA Translation: ABC26158.1 DQ305623 Genomic DNA Translation: ABC26159.1 DQ305624 Genomic DNA Translation: ABC26160.1 DQ305625 Genomic DNA Translation: ABC26161.1 DQ305626 Genomic DNA Translation: ABC26162.1 DQ305627 Genomic DNA Translation: ABC26163.1 DQ305628 Genomic DNA Translation: ABC26164.1 DQ305629 Genomic DNA Translation: ABC26165.1 DQ305630 Genomic DNA Translation: ABC26166.1 DQ305631 Genomic DNA Translation: ABC26167.1 DQ305632 Genomic DNA Translation: ABC26168.1 DQ305633 Genomic DNA Translation: ABC26169.1 DQ305634 Genomic DNA Translation: ABC26170.1 DQ305635 Genomic DNA Translation: ABC26171.1 DQ305636 Genomic DNA Translation: ABC26172.1 DQ305637 Genomic DNA Translation: ABC26173.1 DQ305638 Genomic DNA Translation: ABC26174.1 DQ305639 Genomic DNA Translation: ABC26175.1 DQ305640 Genomic DNA Translation: ABC26176.1 DQ305641 Genomic DNA Translation: ABC26177.1 DQ305642 Genomic DNA Translation: ABC26178.1 DQ305643 Genomic DNA Translation: ABC26179.1 DQ305644 Genomic DNA Translation: ABC26180.1 DQ305645 Genomic DNA Translation: ABC26181.1 DQ305646 Genomic DNA Translation: ABC26182.1 DQ305647 Genomic DNA Translation: ABC26183.1 DQ305648 Genomic DNA Translation: ABC26184.1 DQ305649 Genomic DNA Translation: ABC26185.1 DQ305650 Genomic DNA Translation: ABC26186.1 DQ305651 Genomic DNA Translation: ABC26187.1 DQ305652 Genomic DNA Translation: ABC26188.1 DQ305653 Genomic DNA Translation: ABC26189.1 DQ305654 Genomic DNA Translation: ABC26190.1 DQ305655 Genomic DNA Translation: ABC26191.1 U53473 Genomic DNA Translation: AAA98976.1 AF042740 Genomic DNA Translation: AAC03773.1 AF055874 Genomic DNA Translation: AAC14117.1 AF055875 Genomic DNA Translation: AAC14118.1 AF320309 Genomic DNA Translation: AAG34181.1 AF348074 Genomic DNA Translation: AAK51710.1 AF348075 Genomic DNA Translation: AAK51711.1 Frameshift. AY230251 Genomic DNA Translation: AAO73561.1 AY230252 Genomic DNA Translation: AAO73562.1 CR407631 mRNA Translation: CAG28559.1 AY331807 Genomic DNA Translation: AAP81164.1 AC025062 Genomic DNA No translation available. AC120051 Genomic DNA No translation available. BC015878 mRNA Translation: AAH15878.1 BC067218 mRNA Translation: AAH67218.1 M75163 Genomic DNA Translation: AAA59906.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6008.1
PIRⁱ	B34585 S02788
NCBI Reference Sequences More...RefSeqⁱ	NP_000006.2, NM_000015.2 XP_016868427.1, XM_017012938.1
UniGeneⁱ	Hs.2

Genome annotation databases

Ensemblⁱ	ENST00000286479; ENSP00000286479; ENSG00000156006
GeneIDⁱ	10
KEGGⁱ	hsa:10
UCSC genome browser More...UCSCⁱ	uc003wyw.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P11245	Arylamine N-acetyltransferase 2		HUMAN		290	UniRef100_P11245
Arylamine N-acetyltransferase 2 (Fragment)		HUMAN		147

Protein	Similar proteins		Species	Score	Length	Source
P11245	Arylamine N-acetyltransferase 2		HUMAN		290	UniRef90_P11245
Uncharacterized protein		NOMLE		290
N-acetyltransferase 2 (Arylamine N-acetyltransferase)		PANTR		290
N-acetyltransferase 2		PONAB		290
Arylamine N-acetyltransferase 2 (Fragment)		NOMGA		290
+44

Protein	Similar proteins		Species	Score	Length	Source
P11245	Arylamine N-acetyltransferase 1		MESAU		290	UniRef50_P11245
Arylamine N-acetyltransferase 2		HUMAN		290
N-acetyltransferase 2 (Arylamine N-acetyltransferase)		PANTR		290
Uncharacterized protein		NOMLE		290
N-acetyltransferase 2		PONAB		290
+54

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

NAT

NAT alleles

NIEHS-SNPs

SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X14672 Genomic DNA Translation: CAA32802.1 D90040 mRNA Translation: BAA14094.1 D90042 mRNA Translation: BAA14096.1 D10870 Genomic DNA Translation: BAA01640.1 D10871 Genomic DNA Translation: BAA01641.1 D10872 Genomic DNA Translation: BAA01642.1 U23052 Genomic DNA Translation: AAA64584.1 U23434 Genomic DNA Translation: AAA64585.1 DQ305496 Genomic DNA Translation: ABC26032.1 DQ305497 Genomic DNA Translation: ABC26033.1 DQ305498 Genomic DNA Translation: ABC26034.1 DQ305499 Genomic DNA Translation: ABC26035.1 DQ305500 Genomic DNA Translation: ABC26036.1 DQ305501 Genomic DNA Translation: ABC26037.1 DQ305502 Genomic DNA Translation: ABC26038.1 DQ305503 Genomic DNA Translation: ABC26039.1 DQ305504 Genomic DNA Translation: ABC26040.1 DQ305505 Genomic DNA Translation: ABC26041.1 DQ305506 Genomic DNA Translation: ABC26042.1 DQ305507 Genomic DNA Translation: ABC26043.1 DQ305508 Genomic DNA Translation: ABC26044.1 DQ305509 Genomic DNA Translation: ABC26045.1 DQ305510 Genomic DNA Translation: ABC26046.1 DQ305511 Genomic DNA Translation: ABC26047.1 DQ305512 Genomic DNA Translation: ABC26048.1 DQ305513 Genomic DNA Translation: ABC26049.1 DQ305514 Genomic DNA Translation: ABC26050.1 DQ305515 Genomic DNA Translation: ABC26051.1 DQ305516 Genomic DNA Translation: ABC26052.1 DQ305517 Genomic DNA Translation: ABC26053.1 DQ305518 Genomic DNA Translation: ABC26054.1 DQ305519 Genomic DNA Translation: ABC26055.1 DQ305520 Genomic DNA Translation: ABC26056.1 DQ305521 Genomic DNA Translation: ABC26057.1 DQ305522 Genomic DNA Translation: ABC26058.1 DQ305523 Genomic DNA Translation: ABC26059.1 DQ305524 Genomic DNA Translation: ABC26060.1 DQ305525 Genomic DNA Translation: ABC26061.1 DQ305526 Genomic DNA Translation: ABC26062.1 DQ305527 Genomic DNA Translation: ABC26063.1 DQ305528 Genomic DNA Translation: ABC26064.1 DQ305529 Genomic DNA Translation: ABC26065.1 DQ305530 Genomic DNA Translation: ABC26066.1 DQ305531 Genomic DNA Translation: ABC26067.1 DQ305532 Genomic DNA Translation: ABC26068.1 DQ305533 Genomic DNA Translation: ABC26069.1 DQ305534 Genomic DNA Translation: ABC26070.1 DQ305535 Genomic DNA Translation: ABC26071.1 DQ305536 Genomic DNA Translation: ABC26072.1 DQ305537 Genomic DNA Translation: ABC26073.1 DQ305538 Genomic DNA Translation: ABC26074.1 DQ305539 Genomic DNA Translation: ABC26075.1 DQ305540 Genomic DNA Translation: ABC26076.1 DQ305541 Genomic DNA Translation: ABC26077.1 DQ305542 Genomic DNA Translation: ABC26078.1 DQ305543 Genomic DNA Translation: ABC26079.1 DQ305544 Genomic DNA Translation: ABC26080.1 DQ305545 Genomic DNA Translation: ABC26081.1 DQ305546 Genomic DNA Translation: ABC26082.1 DQ305547 Genomic DNA Translation: ABC26083.1 DQ305548 Genomic DNA Translation: ABC26084.1 DQ305549 Genomic DNA Translation: ABC26085.1 DQ305550 Genomic DNA Translation: ABC26086.1 DQ305551 Genomic DNA Translation: ABC26087.1 DQ305552 Genomic DNA Translation: ABC26088.1 DQ305553 Genomic DNA Translation: ABC26089.1 DQ305554 Genomic DNA Translation: ABC26090.1 DQ305555 Genomic DNA Translation: ABC26091.1 DQ305556 Genomic DNA Translation: ABC26092.1 DQ305557 Genomic DNA Translation: ABC26093.1 DQ305558 Genomic DNA Translation: ABC26094.1 DQ305559 Genomic DNA Translation: ABC26095.1 DQ305560 Genomic DNA Translation: ABC26096.1 DQ305561 Genomic DNA Translation: ABC26097.1 DQ305562 Genomic DNA Translation: ABC26098.1 DQ305563 Genomic DNA Translation: ABC26099.1 DQ305564 Genomic DNA Translation: ABC26100.1 DQ305565 Genomic DNA Translation: ABC26101.1 DQ305566 Genomic DNA Translation: ABC26102.1 DQ305567 Genomic DNA Translation: ABC26103.1 DQ305568 Genomic DNA Translation: ABC26104.1 DQ305569 Genomic DNA Translation: ABC26105.1 DQ305570 Genomic DNA Translation: ABC26106.1 DQ305571 Genomic DNA Translation: ABC26107.1 DQ305572 Genomic DNA Translation: ABC26108.1 DQ305573 Genomic DNA Translation: ABC26109.1 DQ305574 Genomic DNA Translation: ABC26110.1 DQ305575 Genomic DNA Translation: ABC26111.1 DQ305576 Genomic DNA Translation: ABC26112.1 DQ305577 Genomic DNA Translation: ABC26113.1 DQ305578 Genomic DNA Translation: ABC26114.1 DQ305579 Genomic DNA Translation: ABC26115.1 DQ305580 Genomic DNA Translation: ABC26116.1 DQ305581 Genomic DNA Translation: ABC26117.1 DQ305582 Genomic DNA Translation: ABC26118.1 DQ305583 Genomic DNA Translation: ABC26119.1 DQ305584 Genomic DNA Translation: ABC26120.1 DQ305585 Genomic DNA Translation: ABC26121.1 DQ305586 Genomic DNA Translation: ABC26122.1 DQ305587 Genomic DNA Translation: ABC26123.1 DQ305588 Genomic DNA Translation: ABC26124.1 DQ305589 Genomic DNA Translation: ABC26125.1 DQ305590 Genomic DNA Translation: ABC26126.1 DQ305591 Genomic DNA Translation: ABC26127.1 DQ305592 Genomic DNA Translation: ABC26128.1 DQ305593 Genomic DNA Translation: ABC26129.1 DQ305594 Genomic DNA Translation: ABC26130.1 DQ305595 Genomic DNA Translation: ABC26131.1 DQ305596 Genomic DNA Translation: ABC26132.1 DQ305597 Genomic DNA Translation: ABC26133.1 DQ305598 Genomic DNA Translation: ABC26134.1 DQ305599 Genomic DNA Translation: ABC26135.1 DQ305600 Genomic DNA Translation: ABC26136.1 DQ305601 Genomic DNA Translation: ABC26137.1 DQ305602 Genomic DNA Translation: ABC26138.1 DQ305603 Genomic DNA Translation: ABC26139.1 DQ305604 Genomic DNA Translation: ABC26140.1 DQ305605 Genomic DNA Translation: ABC26141.1 DQ305606 Genomic DNA Translation: ABC26142.1 DQ305607 Genomic DNA Translation: ABC26143.1 DQ305608 Genomic DNA Translation: ABC26144.1 DQ305609 Genomic DNA Translation: ABC26145.1 DQ305610 Genomic DNA Translation: ABC26146.1 DQ305611 Genomic DNA Translation: ABC26147.1 DQ305612 Genomic DNA Translation: ABC26148.1 DQ305613 Genomic DNA Translation: ABC26149.1 DQ305614 Genomic DNA Translation: ABC26150.1 DQ305615 Genomic DNA Translation: ABC26151.1 DQ305616 Genomic DNA Translation: ABC26152.1 DQ305617 Genomic DNA Translation: ABC26153.1 DQ305618 Genomic DNA Translation: ABC26154.1 DQ305619 Genomic DNA Translation: ABC26155.1 DQ305620 Genomic DNA Translation: ABC26156.1 DQ305621 Genomic DNA Translation: ABC26157.1 DQ305622 Genomic DNA Translation: ABC26158.1 DQ305623 Genomic DNA Translation: ABC26159.1 DQ305624 Genomic DNA Translation: ABC26160.1 DQ305625 Genomic DNA Translation: ABC26161.1 DQ305626 Genomic DNA Translation: ABC26162.1 DQ305627 Genomic DNA Translation: ABC26163.1 DQ305628 Genomic DNA Translation: ABC26164.1 DQ305629 Genomic DNA Translation: ABC26165.1 DQ305630 Genomic DNA Translation: ABC26166.1 DQ305631 Genomic DNA Translation: ABC26167.1 DQ305632 Genomic DNA Translation: ABC26168.1 DQ305633 Genomic DNA Translation: ABC26169.1 DQ305634 Genomic DNA Translation: ABC26170.1 DQ305635 Genomic DNA Translation: ABC26171.1 DQ305636 Genomic DNA Translation: ABC26172.1 DQ305637 Genomic DNA Translation: ABC26173.1 DQ305638 Genomic DNA Translation: ABC26174.1 DQ305639 Genomic DNA Translation: ABC26175.1 DQ305640 Genomic DNA Translation: ABC26176.1 DQ305641 Genomic DNA Translation: ABC26177.1 DQ305642 Genomic DNA Translation: ABC26178.1 DQ305643 Genomic DNA Translation: ABC26179.1 DQ305644 Genomic DNA Translation: ABC26180.1 DQ305645 Genomic DNA Translation: ABC26181.1 DQ305646 Genomic DNA Translation: ABC26182.1 DQ305647 Genomic DNA Translation: ABC26183.1 DQ305648 Genomic DNA Translation: ABC26184.1 DQ305649 Genomic DNA Translation: ABC26185.1 DQ305650 Genomic DNA Translation: ABC26186.1 DQ305651 Genomic DNA Translation: ABC26187.1 DQ305652 Genomic DNA Translation: ABC26188.1 DQ305653 Genomic DNA Translation: ABC26189.1 DQ305654 Genomic DNA Translation: ABC26190.1 DQ305655 Genomic DNA Translation: ABC26191.1 U53473 Genomic DNA Translation: AAA98976.1 AF042740 Genomic DNA Translation: AAC03773.1 AF055874 Genomic DNA Translation: AAC14117.1 AF055875 Genomic DNA Translation: AAC14118.1 AF320309 Genomic DNA Translation: AAG34181.1 AF348074 Genomic DNA Translation: AAK51710.1 AF348075 Genomic DNA Translation: AAK51711.1 Frameshift. AY230251 Genomic DNA Translation: AAO73561.1 AY230252 Genomic DNA Translation: AAO73562.1 CR407631 mRNA Translation: CAG28559.1 AY331807 Genomic DNA Translation: AAP81164.1 AC025062 Genomic DNA No translation available. AC120051 Genomic DNA No translation available. BC015878 mRNA Translation: AAH15878.1 BC067218 mRNA Translation: AAH67218.1 M75163 Genomic DNA Translation: AAA59906.1
CCDSⁱ	CCDS6008.1
PIRⁱ	B34585 S02788
RefSeqⁱ	NP_000006.2, NM_000015.2 XP_016868427.1, XM_017012938.1
UniGeneⁱ	Hs.2

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2PFR	X-ray	1.92	A/B	2-290	[»]
ProteinModelPortalⁱ	P11245
SMRⁱ	P11245
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	106528, 20 interactors
IntActⁱ	P11245, 19 interactors
MINTⁱ	P11245
STRINGⁱ	9606.ENSP00000286479

Chemistry databases

ChEMBLⁱ	CHEMBL2194
DrugBankⁱ	DB00316 Acetaminophen DB01068 Clonazepam DB00250 Dapsone DB04953 Ezogabine DB00951 Isoniazid DB01015 Sulfamethoxazole

PTM databases

iPTMnetⁱ	P11245
PhosphoSitePlusⁱ	P11245

Polymorphism and mutation databases

BioMutaⁱ	NAT2
DMDMⁱ	114238

Proteomic databases

MaxQBⁱ	P11245
PaxDbⁱ	P11245
PeptideAtlasⁱ	P11245
PRIDEⁱ	P11245
ProteomicsDBⁱ	52728

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	10
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000286479; ENSP00000286479; ENSG00000156006
GeneIDⁱ	10
KEGGⁱ	hsa:10
UCSCⁱ	uc003wyw.2 human

Organism-specific databases

CTDⁱ	10
DisGeNETⁱ	10
EuPathDBⁱ	HostDB:ENSG00000156006.4
GeneCardsⁱ	NAT2
HGNCⁱ	HGNC:7646 NAT2
HPAⁱ	HPA043704
MalaCardsⁱ	NAT2
MIMⁱ	243400 phenotype 612182 gene
neXtProtⁱ	NX_P11245
Orphanetⁱ	240887 Isoniazid toxicity
PharmGKBⁱ	PA18
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IFD6 Eukaryota COG2162 LUCA
HOVERGENⁱ	HBG000165
InParanoidⁱ	P11245
KOⁱ	K00622
OrthoDBⁱ	EOG091G0CO6
PhylomeDBⁱ	P11245
TreeFamⁱ	TF106311

Enzyme and pathway databases

BRENDAⁱ	2.3.1.5 2681
Reactomeⁱ	R-HSA-156582 Acetylation

Miscellaneous databases

EvolutionaryTraceⁱ	P11245
GeneWikiⁱ	N-acetyltransferase_2
GenomeRNAiⁱ	10
Protein Ontology More...PROⁱ	PR:P11245
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000156006 Expressed in 83 organ(s), highest expression level in liver
CleanExⁱ	HS_NAT2
ExpressionAtlasⁱ	P11245 baseline and differential
Genevisibleⁱ	P11245 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR001447 Arylamine_N-AcTrfase IPR038765 Papain_like_cys_pep_sf
PANTHERⁱ	PTHR11786 PTHR11786, 1 hit
Pfamⁱ	View protein in Pfam PF00797 Acetyltransf_2, 1 hit
PRINTSⁱ	PR01543 ANATRNSFRASE
SUPFAMⁱ	SSF54001 SSF54001, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ARY2_HUMAN
Accessionⁱ	P11245Primary (citable) accession number: P11245 Secondary accession number(s): O43637 Q9H220
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
	Last sequence update:	July 1, 1989
	Last modified:	November 7, 2018
	This is version 171 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM

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UniProtKB - P11245 (ARY2_HUMAN)

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Arylamine N-acetyltransferase 2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

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3D structure databases

Miscellaneous databases

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Phylogenomic databases

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<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

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Keywords - Coding sequence diversityi

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ