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UniProtKB - P11245 (ARY2_HUMAN)
Protein
Arylamine N-acetyltransferase 2
Gene
NAT2
Organism
Homo sapiens (Human)
Status
Functioni
Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.
Catalytic activityi
- EC:2.3.1.5
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 68 | Acyl-thioester intermediate | 1 | |
Binding sitei | 103 | Coenzyme A1 Publication | 1 | |
Binding sitei | 104 | Coenzyme A; via amide nitrogen1 Publication | 1 | |
Active sitei | 107 | 1 | ||
Active sitei | 122 | 1 | ||
Binding sitei | 208 | Coenzyme A1 Publication | 1 | |
Binding sitei | 214 | Coenzyme A1 Publication | 1 | |
Binding sitei | 287 | Coenzyme A1 Publication | 1 |
GO - Molecular functioni
- arylamine N-acetyltransferase activity Source: GO_Central
GO - Biological processi
- xenobiotic metabolic process Source: Reactome
Keywordsi
Molecular function | Acyltransferase, Transferase |
Enzyme and pathway databases
BRENDAi | 2.3.1.5, 2681 |
PathwayCommonsi | P11245 |
Reactomei | R-HSA-156582, Acetylation |
SignaLinki | P11245 |
Names & Taxonomyi
Protein namesi | Recommended name: Arylamine N-acetyltransferase 2 (EC:2.3.1.5)Alternative name(s): Arylamide acetylase 2 N-acetyltransferase type 2 Short name: NAT-2 Polymorphic arylamine N-acetyltransferase Short name: PNAT |
Gene namesi | Name:NAT2 Synonyms:AAC2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7646, NAT2 |
MIMi | 612182, gene |
neXtProti | NX_P11245 |
VEuPathDBi | HostDB:ENSG00000156006 |
Subcellular locationi
Cytoplasm and Cytosol
Cytosol
- cytosol Source: Reactome
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 10 |
MalaCardsi | NAT2 |
MIMi | 243400, phenotype |
Orphaneti | 240887, Isoniazid toxicity |
PharmGKBi | PA18 |
Miscellaneous databases
Pharosi | P11245, Tbio |
Chemistry databases
ChEMBLi | CHEMBL2194 |
DrugBanki | DB00316, Acetaminophen DB00945, Acetylsalicylic acid DB11640, Amifampridine DB01068, Clonazepam DB00250, Dapsone DB04953, Ezogabine DB00951, Isoniazid DB12612, Ozanimod DB09288, Propacetamol DB01015, Sulfamethoxazole |
Genetic variation databases
BioMutai | NAT2 |
DMDMi | 114238 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000107905 | 1 – 290 | Arylamine N-acetyltransferase 2Add BLAST | 290 |
Proteomic databases
MassIVEi | P11245 |
MaxQBi | P11245 |
PaxDbi | P11245 |
PeptideAtlasi | P11245 |
PRIDEi | P11245 |
ProteomicsDBi | 52728 |
PTM databases
iPTMneti | P11245 |
PhosphoSitePlusi | P11245 |
Expressioni
Gene expression databases
Bgeei | ENSG00000156006, Expressed in right lobe of liver and 107 other tissues |
ExpressionAtlasi | P11245, baseline and differential |
Genevisiblei | P11245, HS |
Organism-specific databases
HPAi | ENSG00000156006, Group enriched (intestine, liver) |
Interactioni
Binary interactionsi
P11245
With | #Exp. | IntAct |
---|---|---|
ATM [Q13315] | 2 | EBI-9057228,EBI-495465 |
MBD4 - isoform 2 [O95243-2] | 3 | EBI-9057228,EBI-6448717 |
RAD51 [Q06609] | 4 | EBI-9057228,EBI-297202 |
Protein-protein interaction databases
BioGRIDi | 106528, 23 interactors |
IntActi | P11245, 22 interactors |
MINTi | P11245 |
STRINGi | 9606.ENSP00000286479 |
Miscellaneous databases
RNActi | P11245, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P11245 |
SMRi | P11245 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P11245 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 106 – 107 | Substrate bindingCurated | 2 |
Sequence similaritiesi
Belongs to the arylamine N-acetyltransferase family.Curated
Phylogenomic databases
eggNOGi | ENOG502RD0D, Eukaryota |
HOGENOMi | CLU_049918_3_0_1 |
InParanoidi | P11245 |
OrthoDBi | 1545569at2759 |
PhylomeDBi | P11245 |
TreeFami | TF106311 |
Family and domain databases
InterProi | View protein in InterPro IPR001447, Arylamine_N-AcTrfase IPR038765, Papain-like_cys_pep_sf |
PANTHERi | PTHR11786, PTHR11786, 1 hit |
Pfami | View protein in Pfam PF00797, Acetyltransf_2, 1 hit |
PRINTSi | PR01543, ANATRNSFRASE |
SUPFAMi | SSF54001, SSF54001, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P11245-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDIEAYFERI GYKNSRNKLD LETLTDILEH QIRAVPFENL NMHCGQAMEL
60 70 80 90 100
GLEAIFDHIV RRNRGGWCLQ VNQLLYWALT TIGFQTTMLG GYFYIPPVNK
110 120 130 140 150
YSTGMVHLLL QVTIDGRNYI VDAGSGSSSQ MWQPLELISG KDQPQVPCIF
160 170 180 190 200
CLTEERGIWY LDQIRREQYI TNKEFLNSHL LPKKKHQKIY LFTLEPRTIE
210 220 230 240 250
DFESMNTYLQ TSPTSSFITT SFCSLQTPEG VYCLVGFILT YRKFNYKDNT
260 270 280 290
DLVEFKTLTE EEVEEVLRNI FKISLGRNLV PKPGDGSLTI
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE7EWF9 | E7EWF9_HUMAN | Arylamine N-acetyltransferase | NAT2 | 160 | Annotation score: |
Sequence cautioni
The sequence AAK51711 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 6 | Y → D in CAG28559 (Ref. 13) Curated | 1 | |
Sequence conflicti | 30 | H → T AA sequence (PubMed:2924904).Curated | 1 | |
Sequence conflicti | 286 | G → R in AAG34181 (Ref. 9) Curated | 1 |
Polymorphismi
Polymorphisms in NAT2 are the cause of slow and fast acetylation phenotypes [MIMi:243400] and influence drug therapy response and susceptibility to chemical toxicity or carcinogenicity.1 Publication
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_018853 | 24 | L → I2 PublicationsCorresponds to variant dbSNP:rs45477599Ensembl. | 1 | |
Natural variantiVAR_004608 | 64 | R → Q in allele NAT2*14A, allele NAT2*14B, allele NAT2*14C, allele NAT2*14D, allele NAT2*14E, allele NAT2*14F and allele NAT2*14G; a slow acetylator. 4 PublicationsCorresponds to variant dbSNP:rs1801279EnsemblClinVar. | 1 | |
Natural variantiVAR_009075 | 64 | R → W in allele NAT2*19. Corresponds to variant dbSNP:rs1805158Ensembl. | 1 | |
Natural variantiVAR_004609 | 114 | I → T in allele NAT2*5A, allele NAT2*5B, allele NAT2*5C, allele NAT2*5D, allele NAT2*5E, allele NAT2*5F, allele NAT2*14B and allele NAT2*14E; a slow acetylator. 8 PublicationsCorresponds to variant dbSNP:rs1801280EnsemblClinVar. | 1 | |
Natural variantiVAR_020385 | 122 | D → N1 PublicationCorresponds to variant dbSNP:rs4986996Ensembl. | 1 | |
Natural variantiVAR_046905 | 135 | L → V. Corresponds to variant dbSNP:rs12720065Ensembl. | 1 | |
Natural variantiVAR_020386 | 137 | L → F1 PublicationCorresponds to variant dbSNP:rs4986997Ensembl. | 1 | |
Natural variantiVAR_009076 | 145 | Q → P in allele NAT2*17. 1 PublicationCorresponds to variant dbSNP:rs72554616Ensembl. | 1 | |
Natural variantiVAR_028781 | 193 | T → M1 PublicationCorresponds to variant dbSNP:rs79050330Ensembl. | 1 | |
Natural variantiVAR_004610 | 197 | R → Q in allele NAT2*5E, allele NAT2*6A, allele NAT2*6B, allele NAT2*6C, allele NAT2*6D and allele NAT2*14D; a slow acetylator. 5 PublicationsCorresponds to variant dbSNP:rs1799930EnsemblClinVar. | 1 | |
Natural variantiVAR_028782 | 208 | Y → H1 PublicationCorresponds to variant dbSNP:rs56387565Ensembl. | 1 | |
Natural variantiVAR_018854 | 228 | P → L1 PublicationCorresponds to variant dbSNP:rs45518335Ensembl. | 1 | |
Natural variantiVAR_004611 | 268 | R → K in allele NAT2*5A, allele NAT2*5D, allele NAT2*5E, allele NAT2*6A, allele NAT2*6B, allele NAT2*6D, allele NAT2*7A, allele NAT2*7B, NAT2*14A, allele NAT2*14B, allele NAT2*14D, allele NAT2*17, allele NAT2*18, allele NAT2*19. 8 PublicationsCorresponds to variant dbSNP:rs1208Ensembl. | 1 | |
Natural variantiVAR_061368 | 280 | V → M. Corresponds to variant dbSNP:rs56393504EnsemblClinVar. | 1 | |
Natural variantiVAR_009077 | 282 | K → T in allele NAT2*18. 1 PublicationCorresponds to variant dbSNP:rs56054745Ensembl. | 1 | |
Natural variantiVAR_004612 | 286 | G → E in allele NAT2*7A and allele NAT2*7B; a slow acetylator. 4 PublicationsCorresponds to variant dbSNP:rs1799931EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X14672 Genomic DNA Translation: CAA32802.1 D90040 mRNA Translation: BAA14094.1 D90042 mRNA Translation: BAA14096.1 D10870 Genomic DNA Translation: BAA01640.1 D10871 Genomic DNA Translation: BAA01641.1 D10872 Genomic DNA Translation: BAA01642.1 U23052 Genomic DNA Translation: AAA64584.1 U23434 Genomic DNA Translation: AAA64585.1 DQ305496 Genomic DNA Translation: ABC26032.1 DQ305497 Genomic DNA Translation: ABC26033.1 DQ305498 Genomic DNA Translation: ABC26034.1 DQ305499 Genomic DNA Translation: ABC26035.1 DQ305500 Genomic DNA Translation: ABC26036.1 DQ305501 Genomic DNA Translation: ABC26037.1 DQ305502 Genomic DNA Translation: ABC26038.1 DQ305503 Genomic DNA Translation: ABC26039.1 DQ305504 Genomic DNA Translation: ABC26040.1 DQ305505 Genomic DNA Translation: ABC26041.1 DQ305506 Genomic DNA Translation: ABC26042.1 DQ305507 Genomic DNA Translation: ABC26043.1 DQ305508 Genomic DNA Translation: ABC26044.1 DQ305509 Genomic DNA Translation: ABC26045.1 DQ305510 Genomic DNA Translation: ABC26046.1 DQ305511 Genomic DNA Translation: ABC26047.1 DQ305512 Genomic DNA Translation: ABC26048.1 DQ305513 Genomic DNA Translation: ABC26049.1 DQ305514 Genomic DNA Translation: ABC26050.1 DQ305515 Genomic DNA Translation: ABC26051.1 DQ305516 Genomic DNA Translation: ABC26052.1 DQ305517 Genomic DNA Translation: ABC26053.1 DQ305518 Genomic DNA Translation: ABC26054.1 DQ305519 Genomic DNA Translation: ABC26055.1 DQ305520 Genomic DNA Translation: ABC26056.1 DQ305521 Genomic DNA Translation: ABC26057.1 DQ305522 Genomic DNA Translation: ABC26058.1 DQ305523 Genomic DNA Translation: ABC26059.1 DQ305524 Genomic DNA Translation: ABC26060.1 DQ305525 Genomic DNA Translation: ABC26061.1 DQ305526 Genomic DNA Translation: ABC26062.1 DQ305527 Genomic DNA Translation: ABC26063.1 DQ305528 Genomic DNA Translation: ABC26064.1 DQ305529 Genomic DNA Translation: ABC26065.1 DQ305530 Genomic DNA Translation: ABC26066.1 DQ305531 Genomic DNA Translation: ABC26067.1 DQ305532 Genomic DNA Translation: ABC26068.1 DQ305533 Genomic DNA Translation: ABC26069.1 DQ305534 Genomic DNA Translation: ABC26070.1 DQ305535 Genomic DNA Translation: ABC26071.1 DQ305536 Genomic DNA Translation: ABC26072.1 DQ305537 Genomic DNA Translation: ABC26073.1 DQ305538 Genomic DNA Translation: ABC26074.1 DQ305539 Genomic DNA Translation: ABC26075.1 DQ305540 Genomic DNA Translation: ABC26076.1 DQ305541 Genomic DNA Translation: ABC26077.1 DQ305542 Genomic DNA Translation: ABC26078.1 DQ305543 Genomic DNA Translation: ABC26079.1 DQ305544 Genomic DNA Translation: ABC26080.1 DQ305545 Genomic DNA Translation: ABC26081.1 DQ305546 Genomic DNA Translation: ABC26082.1 DQ305547 Genomic DNA Translation: ABC26083.1 DQ305548 Genomic DNA Translation: ABC26084.1 DQ305549 Genomic DNA Translation: ABC26085.1 DQ305550 Genomic DNA Translation: ABC26086.1 DQ305551 Genomic DNA Translation: ABC26087.1 DQ305552 Genomic DNA Translation: ABC26088.1 DQ305553 Genomic DNA Translation: ABC26089.1 DQ305554 Genomic DNA Translation: ABC26090.1 DQ305555 Genomic DNA Translation: ABC26091.1 DQ305556 Genomic DNA Translation: ABC26092.1 DQ305557 Genomic DNA Translation: ABC26093.1 DQ305558 Genomic DNA Translation: ABC26094.1 DQ305559 Genomic DNA Translation: ABC26095.1 DQ305560 Genomic DNA Translation: ABC26096.1 DQ305561 Genomic DNA Translation: ABC26097.1 DQ305562 Genomic DNA Translation: ABC26098.1 DQ305563 Genomic DNA Translation: ABC26099.1 DQ305564 Genomic DNA Translation: ABC26100.1 DQ305565 Genomic DNA Translation: ABC26101.1 DQ305566 Genomic DNA Translation: ABC26102.1 DQ305567 Genomic DNA Translation: ABC26103.1 DQ305568 Genomic DNA Translation: ABC26104.1 DQ305569 Genomic DNA Translation: ABC26105.1 DQ305570 Genomic DNA Translation: ABC26106.1 DQ305571 Genomic DNA Translation: ABC26107.1 DQ305572 Genomic DNA Translation: ABC26108.1 DQ305573 Genomic DNA Translation: ABC26109.1 DQ305574 Genomic DNA Translation: ABC26110.1 DQ305575 Genomic DNA Translation: ABC26111.1 DQ305576 Genomic DNA Translation: ABC26112.1 DQ305577 Genomic DNA Translation: ABC26113.1 DQ305578 Genomic DNA Translation: ABC26114.1 DQ305579 Genomic DNA Translation: ABC26115.1 DQ305580 Genomic DNA Translation: ABC26116.1 DQ305581 Genomic DNA Translation: ABC26117.1 DQ305582 Genomic DNA Translation: ABC26118.1 DQ305583 Genomic DNA Translation: ABC26119.1 DQ305584 Genomic DNA Translation: ABC26120.1 DQ305585 Genomic DNA Translation: ABC26121.1 DQ305586 Genomic DNA Translation: ABC26122.1 DQ305587 Genomic DNA Translation: ABC26123.1 DQ305588 Genomic DNA Translation: ABC26124.1 DQ305589 Genomic DNA Translation: ABC26125.1 DQ305590 Genomic DNA Translation: ABC26126.1 DQ305591 Genomic DNA Translation: ABC26127.1 DQ305592 Genomic DNA Translation: ABC26128.1 DQ305593 Genomic DNA Translation: ABC26129.1 DQ305594 Genomic DNA Translation: ABC26130.1 DQ305595 Genomic DNA Translation: ABC26131.1 DQ305596 Genomic DNA Translation: ABC26132.1 DQ305597 Genomic DNA Translation: ABC26133.1 DQ305598 Genomic DNA Translation: ABC26134.1 DQ305599 Genomic DNA Translation: ABC26135.1 DQ305600 Genomic DNA Translation: ABC26136.1 DQ305601 Genomic DNA Translation: ABC26137.1 DQ305602 Genomic DNA Translation: ABC26138.1 DQ305603 Genomic DNA Translation: ABC26139.1 DQ305604 Genomic DNA Translation: ABC26140.1 DQ305605 Genomic DNA Translation: ABC26141.1 DQ305606 Genomic DNA Translation: ABC26142.1 DQ305607 Genomic DNA Translation: ABC26143.1 DQ305608 Genomic DNA Translation: ABC26144.1 DQ305609 Genomic DNA Translation: ABC26145.1 DQ305610 Genomic DNA Translation: ABC26146.1 DQ305611 Genomic DNA Translation: ABC26147.1 DQ305612 Genomic DNA Translation: ABC26148.1 DQ305613 Genomic DNA Translation: ABC26149.1 DQ305614 Genomic DNA Translation: ABC26150.1 DQ305615 Genomic DNA Translation: ABC26151.1 DQ305616 Genomic DNA Translation: ABC26152.1 DQ305617 Genomic DNA Translation: ABC26153.1 DQ305618 Genomic DNA Translation: ABC26154.1 DQ305619 Genomic DNA Translation: ABC26155.1 DQ305620 Genomic DNA Translation: ABC26156.1 DQ305621 Genomic DNA Translation: ABC26157.1 DQ305622 Genomic DNA Translation: ABC26158.1 DQ305623 Genomic DNA Translation: ABC26159.1 DQ305624 Genomic DNA Translation: ABC26160.1 DQ305625 Genomic DNA Translation: ABC26161.1 DQ305626 Genomic DNA Translation: ABC26162.1 DQ305627 Genomic DNA Translation: ABC26163.1 DQ305628 Genomic DNA Translation: ABC26164.1 DQ305629 Genomic DNA Translation: ABC26165.1 DQ305630 Genomic DNA Translation: ABC26166.1 DQ305631 Genomic DNA Translation: ABC26167.1 DQ305632 Genomic DNA Translation: ABC26168.1 DQ305633 Genomic DNA Translation: ABC26169.1 DQ305634 Genomic DNA Translation: ABC26170.1 DQ305635 Genomic DNA Translation: ABC26171.1 DQ305636 Genomic DNA Translation: ABC26172.1 DQ305637 Genomic DNA Translation: ABC26173.1 DQ305638 Genomic DNA Translation: ABC26174.1 DQ305639 Genomic DNA Translation: ABC26175.1 DQ305640 Genomic DNA Translation: ABC26176.1 DQ305641 Genomic DNA Translation: ABC26177.1 DQ305642 Genomic DNA Translation: ABC26178.1 DQ305643 Genomic DNA Translation: ABC26179.1 DQ305644 Genomic DNA Translation: ABC26180.1 DQ305645 Genomic DNA Translation: ABC26181.1 DQ305646 Genomic DNA Translation: ABC26182.1 DQ305647 Genomic DNA Translation: ABC26183.1 DQ305648 Genomic DNA Translation: ABC26184.1 DQ305649 Genomic DNA Translation: ABC26185.1 DQ305650 Genomic DNA Translation: ABC26186.1 DQ305651 Genomic DNA Translation: ABC26187.1 DQ305652 Genomic DNA Translation: ABC26188.1 DQ305653 Genomic DNA Translation: ABC26189.1 DQ305654 Genomic DNA Translation: ABC26190.1 DQ305655 Genomic DNA Translation: ABC26191.1 U53473 Genomic DNA Translation: AAA98976.1 AF042740 Genomic DNA Translation: AAC03773.1 AF055874 Genomic DNA Translation: AAC14117.1 AF055875 Genomic DNA Translation: AAC14118.1 AF320309 Genomic DNA Translation: AAG34181.1 AF348074 Genomic DNA Translation: AAK51710.1 AF348075 Genomic DNA Translation: AAK51711.1 Frameshift. AY230251 Genomic DNA Translation: AAO73561.1 AY230252 Genomic DNA Translation: AAO73562.1 CR407631 mRNA Translation: CAG28559.1 AY331807 Genomic DNA Translation: AAP81164.1 AC025062 Genomic DNA No translation available. AC120051 Genomic DNA No translation available. BC015878 mRNA Translation: AAH15878.1 BC067218 mRNA Translation: AAH67218.1 M75163 Genomic DNA Translation: AAA59906.1 |
CCDSi | CCDS6008.1 |
PIRi | B34585 S02788 |
RefSeqi | NP_000006.2, NM_000015.2 XP_016868427.1, XM_017012938.1 |
Genome annotation databases
Ensembli | ENST00000286479.4; ENSP00000286479.3; ENSG00000156006.5 |
GeneIDi | 10 |
KEGGi | hsa:10 |
MANE-Selecti | ENST00000286479.4; ENSP00000286479.3; NM_000015.3; NP_000006.2 |
UCSCi | uc003wyw.2, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
NAT NAT alleles |
NIEHS-SNPs |
SHMPD The Singapore human mutation and polymorphism database |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X14672 Genomic DNA Translation: CAA32802.1 D90040 mRNA Translation: BAA14094.1 D90042 mRNA Translation: BAA14096.1 D10870 Genomic DNA Translation: BAA01640.1 D10871 Genomic DNA Translation: BAA01641.1 D10872 Genomic DNA Translation: BAA01642.1 U23052 Genomic DNA Translation: AAA64584.1 U23434 Genomic DNA Translation: AAA64585.1 DQ305496 Genomic DNA Translation: ABC26032.1 DQ305497 Genomic DNA Translation: ABC26033.1 DQ305498 Genomic DNA Translation: ABC26034.1 DQ305499 Genomic DNA Translation: ABC26035.1 DQ305500 Genomic DNA Translation: ABC26036.1 DQ305501 Genomic DNA Translation: ABC26037.1 DQ305502 Genomic DNA Translation: ABC26038.1 DQ305503 Genomic DNA Translation: ABC26039.1 DQ305504 Genomic DNA Translation: ABC26040.1 DQ305505 Genomic DNA Translation: ABC26041.1 DQ305506 Genomic DNA Translation: ABC26042.1 DQ305507 Genomic DNA Translation: ABC26043.1 DQ305508 Genomic DNA Translation: ABC26044.1 DQ305509 Genomic DNA Translation: ABC26045.1 DQ305510 Genomic DNA Translation: ABC26046.1 DQ305511 Genomic DNA Translation: ABC26047.1 DQ305512 Genomic DNA Translation: ABC26048.1 DQ305513 Genomic DNA Translation: ABC26049.1 DQ305514 Genomic DNA Translation: ABC26050.1 DQ305515 Genomic DNA Translation: ABC26051.1 DQ305516 Genomic DNA Translation: ABC26052.1 DQ305517 Genomic DNA Translation: ABC26053.1 DQ305518 Genomic DNA Translation: ABC26054.1 DQ305519 Genomic DNA Translation: ABC26055.1 DQ305520 Genomic DNA Translation: ABC26056.1 DQ305521 Genomic DNA Translation: ABC26057.1 DQ305522 Genomic DNA Translation: ABC26058.1 DQ305523 Genomic DNA Translation: ABC26059.1 DQ305524 Genomic DNA Translation: ABC26060.1 DQ305525 Genomic DNA Translation: ABC26061.1 DQ305526 Genomic DNA Translation: ABC26062.1 DQ305527 Genomic DNA Translation: ABC26063.1 DQ305528 Genomic DNA Translation: ABC26064.1 DQ305529 Genomic DNA Translation: ABC26065.1 DQ305530 Genomic DNA Translation: ABC26066.1 DQ305531 Genomic DNA Translation: ABC26067.1 DQ305532 Genomic DNA Translation: ABC26068.1 DQ305533 Genomic DNA Translation: ABC26069.1 DQ305534 Genomic DNA Translation: ABC26070.1 DQ305535 Genomic DNA Translation: ABC26071.1 DQ305536 Genomic DNA Translation: ABC26072.1 DQ305537 Genomic DNA Translation: ABC26073.1 DQ305538 Genomic DNA Translation: ABC26074.1 DQ305539 Genomic DNA Translation: ABC26075.1 DQ305540 Genomic DNA Translation: ABC26076.1 DQ305541 Genomic DNA Translation: ABC26077.1 DQ305542 Genomic DNA Translation: ABC26078.1 DQ305543 Genomic DNA Translation: ABC26079.1 DQ305544 Genomic DNA Translation: ABC26080.1 DQ305545 Genomic DNA Translation: ABC26081.1 DQ305546 Genomic DNA Translation: ABC26082.1 DQ305547 Genomic DNA Translation: ABC26083.1 DQ305548 Genomic DNA Translation: ABC26084.1 DQ305549 Genomic DNA Translation: ABC26085.1 DQ305550 Genomic DNA Translation: ABC26086.1 DQ305551 Genomic DNA Translation: ABC26087.1 DQ305552 Genomic DNA Translation: ABC26088.1 DQ305553 Genomic DNA Translation: ABC26089.1 DQ305554 Genomic DNA Translation: ABC26090.1 DQ305555 Genomic DNA Translation: ABC26091.1 DQ305556 Genomic DNA Translation: ABC26092.1 DQ305557 Genomic DNA Translation: ABC26093.1 DQ305558 Genomic DNA Translation: ABC26094.1 DQ305559 Genomic DNA Translation: ABC26095.1 DQ305560 Genomic DNA Translation: ABC26096.1 DQ305561 Genomic DNA Translation: ABC26097.1 DQ305562 Genomic DNA Translation: ABC26098.1 DQ305563 Genomic DNA Translation: ABC26099.1 DQ305564 Genomic DNA Translation: ABC26100.1 DQ305565 Genomic DNA Translation: ABC26101.1 DQ305566 Genomic DNA Translation: ABC26102.1 DQ305567 Genomic DNA Translation: ABC26103.1 DQ305568 Genomic DNA Translation: ABC26104.1 DQ305569 Genomic DNA Translation: ABC26105.1 DQ305570 Genomic DNA Translation: ABC26106.1 DQ305571 Genomic DNA Translation: ABC26107.1 DQ305572 Genomic DNA Translation: ABC26108.1 DQ305573 Genomic DNA Translation: ABC26109.1 DQ305574 Genomic DNA Translation: ABC26110.1 DQ305575 Genomic DNA Translation: ABC26111.1 DQ305576 Genomic DNA Translation: ABC26112.1 DQ305577 Genomic DNA Translation: ABC26113.1 DQ305578 Genomic DNA Translation: ABC26114.1 DQ305579 Genomic DNA Translation: ABC26115.1 DQ305580 Genomic DNA Translation: ABC26116.1 DQ305581 Genomic DNA Translation: ABC26117.1 DQ305582 Genomic DNA Translation: ABC26118.1 DQ305583 Genomic DNA Translation: ABC26119.1 DQ305584 Genomic DNA Translation: ABC26120.1 DQ305585 Genomic DNA Translation: ABC26121.1 DQ305586 Genomic DNA Translation: ABC26122.1 DQ305587 Genomic DNA Translation: ABC26123.1 DQ305588 Genomic DNA Translation: ABC26124.1 DQ305589 Genomic DNA Translation: ABC26125.1 DQ305590 Genomic DNA Translation: ABC26126.1 DQ305591 Genomic DNA Translation: ABC26127.1 DQ305592 Genomic DNA Translation: ABC26128.1 DQ305593 Genomic DNA Translation: ABC26129.1 DQ305594 Genomic DNA Translation: ABC26130.1 DQ305595 Genomic DNA Translation: ABC26131.1 DQ305596 Genomic DNA Translation: ABC26132.1 DQ305597 Genomic DNA Translation: ABC26133.1 DQ305598 Genomic DNA Translation: ABC26134.1 DQ305599 Genomic DNA Translation: ABC26135.1 DQ305600 Genomic DNA Translation: ABC26136.1 DQ305601 Genomic DNA Translation: ABC26137.1 DQ305602 Genomic DNA Translation: ABC26138.1 DQ305603 Genomic DNA Translation: ABC26139.1 DQ305604 Genomic DNA Translation: ABC26140.1 DQ305605 Genomic DNA Translation: ABC26141.1 DQ305606 Genomic DNA Translation: ABC26142.1 DQ305607 Genomic DNA Translation: ABC26143.1 DQ305608 Genomic DNA Translation: ABC26144.1 DQ305609 Genomic DNA Translation: ABC26145.1 DQ305610 Genomic DNA Translation: ABC26146.1 DQ305611 Genomic DNA Translation: ABC26147.1 DQ305612 Genomic DNA Translation: ABC26148.1 DQ305613 Genomic DNA Translation: ABC26149.1 DQ305614 Genomic DNA Translation: ABC26150.1 DQ305615 Genomic DNA Translation: ABC26151.1 DQ305616 Genomic DNA Translation: ABC26152.1 DQ305617 Genomic DNA Translation: ABC26153.1 DQ305618 Genomic DNA Translation: ABC26154.1 DQ305619 Genomic DNA Translation: ABC26155.1 DQ305620 Genomic DNA Translation: ABC26156.1 DQ305621 Genomic DNA Translation: ABC26157.1 DQ305622 Genomic DNA Translation: ABC26158.1 DQ305623 Genomic DNA Translation: ABC26159.1 DQ305624 Genomic DNA Translation: ABC26160.1 DQ305625 Genomic DNA Translation: ABC26161.1 DQ305626 Genomic DNA Translation: ABC26162.1 DQ305627 Genomic DNA Translation: ABC26163.1 DQ305628 Genomic DNA Translation: ABC26164.1 DQ305629 Genomic DNA Translation: ABC26165.1 DQ305630 Genomic DNA Translation: ABC26166.1 DQ305631 Genomic DNA Translation: ABC26167.1 DQ305632 Genomic DNA Translation: ABC26168.1 DQ305633 Genomic DNA Translation: ABC26169.1 DQ305634 Genomic DNA Translation: ABC26170.1 DQ305635 Genomic DNA Translation: ABC26171.1 DQ305636 Genomic DNA Translation: ABC26172.1 DQ305637 Genomic DNA Translation: ABC26173.1 DQ305638 Genomic DNA Translation: ABC26174.1 DQ305639 Genomic DNA Translation: ABC26175.1 DQ305640 Genomic DNA Translation: ABC26176.1 DQ305641 Genomic DNA Translation: ABC26177.1 DQ305642 Genomic DNA Translation: ABC26178.1 DQ305643 Genomic DNA Translation: ABC26179.1 DQ305644 Genomic DNA Translation: ABC26180.1 DQ305645 Genomic DNA Translation: ABC26181.1 DQ305646 Genomic DNA Translation: ABC26182.1 DQ305647 Genomic DNA Translation: ABC26183.1 DQ305648 Genomic DNA Translation: ABC26184.1 DQ305649 Genomic DNA Translation: ABC26185.1 DQ305650 Genomic DNA Translation: ABC26186.1 DQ305651 Genomic DNA Translation: ABC26187.1 DQ305652 Genomic DNA Translation: ABC26188.1 DQ305653 Genomic DNA Translation: ABC26189.1 DQ305654 Genomic DNA Translation: ABC26190.1 DQ305655 Genomic DNA Translation: ABC26191.1 U53473 Genomic DNA Translation: AAA98976.1 AF042740 Genomic DNA Translation: AAC03773.1 AF055874 Genomic DNA Translation: AAC14117.1 AF055875 Genomic DNA Translation: AAC14118.1 AF320309 Genomic DNA Translation: AAG34181.1 AF348074 Genomic DNA Translation: AAK51710.1 AF348075 Genomic DNA Translation: AAK51711.1 Frameshift. AY230251 Genomic DNA Translation: AAO73561.1 AY230252 Genomic DNA Translation: AAO73562.1 CR407631 mRNA Translation: CAG28559.1 AY331807 Genomic DNA Translation: AAP81164.1 AC025062 Genomic DNA No translation available. AC120051 Genomic DNA No translation available. BC015878 mRNA Translation: AAH15878.1 BC067218 mRNA Translation: AAH67218.1 M75163 Genomic DNA Translation: AAA59906.1 |
CCDSi | CCDS6008.1 |
PIRi | B34585 S02788 |
RefSeqi | NP_000006.2, NM_000015.2 XP_016868427.1, XM_017012938.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2PFR | X-ray | 1.92 | A/B | 2-290 | [»] | |
AlphaFoldDBi | P11245 | |||||
SMRi | P11245 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 106528, 23 interactors |
IntActi | P11245, 22 interactors |
MINTi | P11245 |
STRINGi | 9606.ENSP00000286479 |
Chemistry databases
ChEMBLi | CHEMBL2194 |
DrugBanki | DB00316, Acetaminophen DB00945, Acetylsalicylic acid DB11640, Amifampridine DB01068, Clonazepam DB00250, Dapsone DB04953, Ezogabine DB00951, Isoniazid DB12612, Ozanimod DB09288, Propacetamol DB01015, Sulfamethoxazole |
PTM databases
iPTMneti | P11245 |
PhosphoSitePlusi | P11245 |
Genetic variation databases
BioMutai | NAT2 |
DMDMi | 114238 |
Proteomic databases
MassIVEi | P11245 |
MaxQBi | P11245 |
PaxDbi | P11245 |
PeptideAtlasi | P11245 |
PRIDEi | P11245 |
ProteomicsDBi | 52728 |
Protocols and materials databases
Antibodypediai | 22356, 259 antibodies from 27 providers |
DNASUi | 10 |
Genome annotation databases
Ensembli | ENST00000286479.4; ENSP00000286479.3; ENSG00000156006.5 |
GeneIDi | 10 |
KEGGi | hsa:10 |
MANE-Selecti | ENST00000286479.4; ENSP00000286479.3; NM_000015.3; NP_000006.2 |
UCSCi | uc003wyw.2, human |
Organism-specific databases
CTDi | 10 |
DisGeNETi | 10 |
GeneCardsi | NAT2 |
HGNCi | HGNC:7646, NAT2 |
HPAi | ENSG00000156006, Group enriched (intestine, liver) |
MalaCardsi | NAT2 |
MIMi | 243400, phenotype 612182, gene |
neXtProti | NX_P11245 |
Orphaneti | 240887, Isoniazid toxicity |
PharmGKBi | PA18 |
VEuPathDBi | HostDB:ENSG00000156006 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RD0D, Eukaryota |
HOGENOMi | CLU_049918_3_0_1 |
InParanoidi | P11245 |
OrthoDBi | 1545569at2759 |
PhylomeDBi | P11245 |
TreeFami | TF106311 |
Enzyme and pathway databases
BRENDAi | 2.3.1.5, 2681 |
PathwayCommonsi | P11245 |
Reactomei | R-HSA-156582, Acetylation |
SignaLinki | P11245 |
Miscellaneous databases
BioGRID-ORCSi | 10, 11 hits in 1064 CRISPR screens |
ChiTaRSi | NAT2, human |
EvolutionaryTracei | P11245 |
GeneWikii | N-acetyltransferase_2 |
GenomeRNAii | 10 |
Pharosi | P11245, Tbio |
PROi | PR:P11245 |
RNActi | P11245, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000156006, Expressed in right lobe of liver and 107 other tissues |
ExpressionAtlasi | P11245, baseline and differential |
Genevisiblei | P11245, HS |
Family and domain databases
InterProi | View protein in InterPro IPR001447, Arylamine_N-AcTrfase IPR038765, Papain-like_cys_pep_sf |
PANTHERi | PTHR11786, PTHR11786, 1 hit |
Pfami | View protein in Pfam PF00797, Acetyltransf_2, 1 hit |
PRINTSi | PR01543, ANATRNSFRASE |
SUPFAMi | SSF54001, SSF54001, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ARY2_HUMAN | |
Accessioni | P11245Primary (citable) accession number: P11245 Secondary accession number(s): O43637 Q9H220 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | February 23, 2022 | |
Last modified: | May 25, 2022 | |
This is version 191 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families