RALB

Functionⁱ

Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles (By similarity). Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells (By similarity). Required for suppression of apoptosis (PubMed:17875936). In late stages of cytokinesis, upon completion of the bridge formation between dividing cells, mediates exocyst recruitment to the midbody to drive abscission (PubMed:18756269).By similarity2 Publications

Activity regulationⁱ

Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	21 – 29	GTP	9
Nucleotide bindingⁱ	68 – 72	GTP	5
Nucleotide bindingⁱ	128 – 131	GTP	4
Nucleotide bindingⁱ	158 – 160	GTP	3

GO - Molecular functionⁱ

ATPase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 24056301
GDP binding
Source: UniProtKB
Inferred from direct assayⁱ
- 24056301
GTPase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 19166349
GTP binding
Source: UniProtKB
Inferred from direct assayⁱ
- 19166349
ubiquitin protein ligase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 24056301

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

apoptotic process Source: UniProtKB-KW
cell cycle Source: UniProtKB-KW
cell division Source: UniProtKB-KW
cellular response to exogenous dsRNA
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24056301
cellular response to starvation
Source: UniProtKB
Inferred from direct assayⁱ
- 24056301
negative regulation of protein binding
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24056301
positive regulation of autophagosome assembly
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24056301
positive regulation of protein binding
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24056301
positive regulation of protein phosphorylation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24056301
positive regulation of protein serine/threonine kinase activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24056301
Ras protein signal transduction Source: InterPro
regulation of exocyst assembly Source: UniProtKB
regulation of exocyst localization Source: UniProtKB
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 2120779

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Apoptosis, Cell cycle, Cell division
Ligand	GTP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-171007 p38MAPK events
SIGNORⁱ	P11234

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ras-related protein Ral-B
Gene namesⁱ	Name:RALB
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000144118.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9840 RALB
MIMⁱ	179551 gene
neXtProtⁱ	NX_P11234

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	1 – 11	Missing : No effect on cytokinesis. Impaired cytokinesis, as shown by increased number of binucleate cells; when associated with V-23. 1 PublicationAdd BLAST	11
Mutagenesisⁱ	23	G → V: Impaired cytokinesis, as shown by increased number of binucleate cells. Impaired cytokinesis; when associated with 1-M--S-11 or N-49. No effect on cytokinesis; when associated with R-38, W-48 or E-49. No effect on interaction with EXOC2 and EXOC8. Decreased interaction with EXOC2 and EXOC8; when associated with R-38 or W-48. 1 Publication	1
Mutagenesisⁱ	38	E → R: No effect on cytokinesis. No effect on cytokinesis; when associated with V-23. Decreased interaction with EXOC2 and EXOC8; when associated with V-23. 1 Publication	1
Mutagenesisⁱ	46	T → A: Reduces the binding affinity to EXOC2 effector. 1 Publication	1
Mutagenesisⁱ	46	T → S: Reduces the binding affinity to EXOC2 effector. 1 Publication	1
Mutagenesisⁱ	48	A → W: Impaired abscission, the last step of cytokinesis, as shown by the accumulation of bridged cells. No effect on cytokinesis; when associated with V-23. Decreased interaction with EXOC2 and EXOC8; when associated with V-23. 1 Publication	1
Mutagenesisⁱ	49	D → E: Impaired abscission, the last step of cytokinesis. No effect on cytokinesis; when associated with V-23. 1 Publication	1
Mutagenesisⁱ	49	D → N: No effect on cytokinesis. Impaired cytokinesis, as shown by increased number of binucleate cells; when associated with V-23. 1 Publication	1
Mutagenesisⁱ	72	Q → L: Loss of GTPase activity. 1 Publication	1
Mutagenesisⁱ	203	C → S: Loss of geranylgeranylation and membrane localization. 1 Publication	1
Mutagenesisⁱ	206	L → S: Converts geranyl-geranylation to farnesylation. No effect on membrane localization. Confers resistance to GGTI-induced pancreatic cancer cell apoptosis, but not to GGTI-dependent inhibition of anchorage-independent proliferation. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5899
Open Targets More...OpenTargetsⁱ	ENSG00000144118
PharmGKBⁱ	PA34198

Chemistry databases

ChEMBLⁱ	CHEMBL3879851

ChEMBLⁱ

CHEMBL3879851

Polymorphism and mutation databases

BioMutaⁱ	RALB
DMDMⁱ	131835

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000082698	1 – 203	Ras-related protein Ral-BAdd BLAST		203
PropeptideⁱPRO_0000281349	204 – 206	Removed in mature formBy similarity		3

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	203	Cysteine methyl esterBy similarity		1
Lipidationⁱ	203	S-geranylgeranyl cysteine1 Publication		1

Post-translational modificationⁱ

Prenylation is essential for membrane localization. The geranylgeranylated form and the farnesylated mutant does not undergo alternative prenylation in response to geranylgeranyltransferase I inhibitors (GGTIs) and farnesyltransferase I inhibitors (FTIs).1 Publication

The farnesylated form confers resistance to the proapoptotic and anti-anchorage-dependent growth effects of geranylgeranyltransferase I inhibitors, including GGTI-2417.1 Publication

Keywords - PTMⁱ

Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDⁱ	P11234
PaxDbⁱ	P11234
PeptideAtlas More...PeptideAtlasⁱ	P11234
PRIDEⁱ	P11234
ProteomicsDBⁱ	52727

PTM databases

iPTMnetⁱ	P11234
PhosphoSitePlusⁱ	P11234
SwissPalmⁱ	P11234

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000144118 Expressed in 230 organ(s), highest expression level in frontal cortex
CleanExⁱ	HS_RALB
ExpressionAtlasⁱ	P11234 baseline and differential
Genevisibleⁱ	P11234 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB026010 HPA065232

HPAⁱ

CAB026010
HPA065232

Interactionⁱ

Subunit structureⁱ

Interacts with EXOC2/Sec5 and EXOC8/Exo84 (PubMed:14525976, PubMed:18756269, PubMed:19166349). Interacts (via effector domain) with RALBP1 (PubMed:7673236, PubMed:20696399).5 Publications

GO - Molecular functionⁱ

ATPase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 24056301
ubiquitin protein ligase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 24056301

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111835, 35 interactors
IntActⁱ	P11234, 20 interactors
Molecular INTeraction database More...MINTⁱ	P11234
STRINGⁱ	9606.ENSP00000272519

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	10 – 12	Combined sources	3
Beta strandⁱ	14 – 25	Combined sources	12
Helixⁱ	27 – 36	Combined sources	10
Beta strandⁱ	51 – 56	Combined sources	6
Beta strandⁱ	61 – 68	Combined sources	8
Beta strandⁱ	74 – 77	Combined sources	4
Helixⁱ	78 – 84	Combined sources	7
Beta strandⁱ	87 – 96	Combined sources	10
Helixⁱ	98 – 114	Combined sources	17
Beta strandⁱ	117 – 119	Combined sources	3
Beta strandⁱ	123 – 128	Combined sources	6
Helixⁱ	140 – 148	Combined sources	9
Turnⁱ	149 – 151	Combined sources	3
Beta strandⁱ	154 – 156	Combined sources	3
Turnⁱ	159 – 161	Combined sources	3
Helixⁱ	165 – 179	Combined sources	15
Turnⁱ	180 – 182	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	P11234
SMRⁱ	P11234
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P11234

EvolutionaryTraceⁱ

P11234

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	43 – 51	Effector region		9

Sequence similaritiesⁱ

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0395 Eukaryota COG1100 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00860000133672
HOGENOMⁱ	HOG000233973
HOVERGENⁱ	HBG009351
InParanoidⁱ	P11234
KEGG Orthology (KO) More...KOⁱ	K07835
OMAⁱ	ADEWGVQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0UAU
PhylomeDBⁱ	P11234
TreeFamⁱ	TF312796

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR028412 Ral IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase IPR020849 Small_GTPase_Ras-type
PANTHERⁱ	PTHR24070 PTHR24070, 1 hit PTHR24070:SF199 PTHR24070:SF199, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51421 RAS, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P11234-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAANKSKGQS SLALHKVIMV GSGGVGKSAL TLQFMYDEFV EDYEPTKADS 
        60         70         80         90        100
YRKKVVLDGE EVQIDILDTA GQEDYAAIRD NYFRSGEGFL LVFSITEHES 
       110        120        130        140        150
FTATAEFREQ ILRVKAEEDK IPLLVVGNKS DLEERRQVPV EEARSKAEEW 
       160        170        180        190        200
GVQYVETSAK TRANVDKVFF DLMREIRTKK MSENKDKNGK KSSKNKKSFK 

ERCCLL

Length:206

Mass (Da):23,409

Last modified:July 1, 1989 - v1

Checksum:ⁱE0AC95130FB6452C

GO

Isoform 2 (identifier: P11234-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MKQRQSALQWVICVSQPQKTSEM

« Hide

        10         20         30         40         50
MKQRQSALQW VICVSQPQKT SEMAANKSKG QSSLALHKVI MVGSGGVGKS 
        60         70         80         90        100
ALTLQFMYDE FVEDYEPTKA DSYRKKVVLD GEEVQIDILD TAGQEDYAAI 
       110        120        130        140        150
RDNYFRSGEG FLLVFSITEH ESFTATAEFR EQILRVKAEE DKIPLLVVGN 
       160        170        180        190        200
KSDLEERRQV PVEEARSKAE EWGVQYVETS AKTRANVDKV FFDLMREIRT 
       210        220 
KKMSENKDKN GKKSSKNKKS FKERCCLL

Note: No experimental confirmation available.

Show »

Length:228

Mass (Da):25,967

Checksum:ⁱB36FAF7D688B0861

GO

Isoform 3 (identifier: P11234-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
36-37: YD → NVSKSLAYDKKKYTANKKVEGIL

« Hide

        10         20         30         40         50
MAANKSKGQS SLALHKVIMV GSGGVGKSAL TLQFMNVSKS LAYDKKKYTA 
        60         70         80         90        100
NKKVEGILEF VEDYEPTKAD SYRKKVVLDG EEVQIDILDT AGQEDYAAIR 
       110        120        130        140        150
DNYFRSGEGF LLVFSITEHE SFTATAEFRE QILRVKAEED KIPLLVVGNK 
       160        170        180        190        200
SDLEERRQVP VEEARSKAEE WGVQYVETSA KTRANVDKVF FDLMREIRTK 
       210        220 
KMSENKDKNG KKSSKNKKSF KERCCLL

Note: No experimental confirmation available.

Show »

Length:227

Mass (Da):25,710

Checksum:ⁱ174A6FBCF109A103

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9JYR1	C9JYR1_HUMAN	Ras-related protein Ral-B Ras-related protein Ral-B	RALB	112	Annotation score:
C9J6B1	C9J6B1_HUMAN	Ras-related protein Ral-B Ras-related protein Ral-B	RALB	167	Annotation score:
C9JQB3	C9JQB3_HUMAN	Ras-related protein Ral-B Ras-related protein Ral-B	RALB	171	Annotation score:
F8WEQ6	F8WEQ6_HUMAN	Ras-related protein Ral-B Ras-related protein Ral-B	RALB	46	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_055843	1	M → MKQRQSALQWVICVSQPQKT SEM in isoform 2. 1 Publication		1
Alternative sequenceⁱVSP_055844	36 – 37	YD → NVSKSLAYDKKKYTANKKVE GIL in isoform 3. 1 Publication		2

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X15015 mRNA Translation: CAA33119.1 M35416 mRNA Translation: AAA60250.1 AF493911 mRNA Translation: AAM12625.1 BT006953 mRNA Translation: AAP35599.1 AK127675 mRNA Translation: BAC87080.1 AK303214 mRNA Translation: BAG64302.1 AK312453 mRNA Translation: BAG35360.1 AC012363 Genomic DNA Translation: AAY14800.1 CH471103 Genomic DNA Translation: EAW95240.1 CH471103 Genomic DNA Translation: EAW95242.1 BC018163 mRNA Translation: AAH18163.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2131.1 [P11234-1]
PIRⁱ	S04597 TVHUAB
NCBI Reference Sequences More...RefSeqⁱ	NP_002872.1, NM_002881.2 [P11234-1] XP_005263781.1, XM_005263724.1 XP_005263784.1, XM_005263727.1 [P11234-1] XP_005263785.1, XM_005263728.1 [P11234-1] XP_005263786.1, XM_005263729.2 XP_016860111.1, XM_017004622.1
UniGeneⁱ	Hs.469820

Genome annotation databases

Ensemblⁱ	ENST00000272519; ENSP00000272519; ENSG00000144118 [P11234-1] ENST00000420510; ENSP00000414224; ENSG00000144118 [P11234-1]
GeneIDⁱ	5899
KEGGⁱ	hsa:5899
UCSC genome browser More...UCSCⁱ	uc002tmk.4 human [P11234-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P11234	Ras-related protein Ral-B		PONAB		206	UniRef100_P11234
Uncharacterized protein		PANTR		212
Uncharacterized protein		PANPA		212
Uncharacterized protein		NOMLE		212
V-ral simian leukemia viral oncogene homolog B (Ras related GTP binding protein), isoform CRA_a		HUMAN		206
+3
P11234-2	Uncharacterized protein		PANPA		254	UniRef100_A0A2R9BAM5
Ras-related protein Ral-B (Fragment)		HUMAN		171
RALB isoform 6 (Fragment)		PANTR		171

Protein	Similar proteins		Species	Score	Length	Source
P11234	Ras-related protein Ral-B		PONAB		206	UniRef90_P11234
Uncharacterized protein		PANTR		212
Uncharacterized protein		PANPA		212
Uncharacterized protein		NOMLE		212
V-ral simian leukemia viral oncogene homolog B (Ras related GTP binding protein), isoform CRA_a		HUMAN		206
+15
P11234-2	Ras-related protein ralB-A		XENLA		206	UniRef90_Q9YH09
Ras-related protein Ral-B		MOUSE		206
Ras-related protein Ral-B		RAT		206
Ras-related protein O-RAL		DIPOM		206
Uncharacterized protein		PANPA		254
+97
P11234-3	Uncharacterized protein		MACMU		227	UniRef90_P11234-3
Uncharacterized protein		MACFA		227
ras-related protein Ral-B isoform X1		TURTR		182
UPI0000207E30		HUMAN		195

Protein	Similar proteins		Species	Score	Length	Source
P11234	Ras-related protein Ral-B		PONAB		206	UniRef50_P11234
Ras-related protein Ral-B		MACFA		206
Uncharacterized protein		PANTR		212
Uncharacterized protein		PANPA		212
Uncharacterized protein		NOMLE		212
+41
P11234-2	Ras-related protein ralB-A		XENLA		206	UniRef50_Q9YH09
Ras-related protein Ral-B		RAT		206
Ras-related protein O-RAL		DIPOM		206
Ras-related protein Ral-B		MOUSE		206
Uncharacterized protein		PANPA		254
+285
P11234-3	Uncharacterized protein		MACMU		227	UniRef50_P11234-3
Uncharacterized protein		MACFA		227
ras-related protein Ral-B isoform X1		TURTR		182
RAS like proto-oncogene B		MELGA		230
Ras family protein		OESDE		210
+27

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X15015 mRNA Translation: CAA33119.1 M35416 mRNA Translation: AAA60250.1 AF493911 mRNA Translation: AAM12625.1 BT006953 mRNA Translation: AAP35599.1 AK127675 mRNA Translation: BAC87080.1 AK303214 mRNA Translation: BAG64302.1 AK312453 mRNA Translation: BAG35360.1 AC012363 Genomic DNA Translation: AAY14800.1 CH471103 Genomic DNA Translation: EAW95240.1 CH471103 Genomic DNA Translation: EAW95242.1 BC018163 mRNA Translation: AAH18163.1
CCDSⁱ	CCDS2131.1 [P11234-1]
PIRⁱ	S04597 TVHUAB
RefSeqⁱ	NP_002872.1, NM_002881.2 [P11234-1] XP_005263781.1, XM_005263724.1 XP_005263784.1, XM_005263727.1 [P11234-1] XP_005263785.1, XM_005263728.1 [P11234-1] XP_005263786.1, XM_005263729.2 XP_016860111.1, XM_017004622.1
UniGeneⁱ	Hs.469820

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2KE5	NMR	-	A	12-185	[»]
	2KWI	NMR	-	A	8-185	[»]
ProteinModelPortalⁱ	P11234
SMRⁱ	P11234
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111835, 35 interactors
IntActⁱ	P11234, 20 interactors
MINTⁱ	P11234
STRINGⁱ	9606.ENSP00000272519

Chemistry databases

ChEMBLⁱ	CHEMBL3879851

ChEMBLⁱ

CHEMBL3879851

PTM databases

iPTMnetⁱ	P11234
PhosphoSitePlusⁱ	P11234
SwissPalmⁱ	P11234

Polymorphism and mutation databases

BioMutaⁱ	RALB
DMDMⁱ	131835

Proteomic databases

EPDⁱ	P11234
PaxDbⁱ	P11234
PeptideAtlasⁱ	P11234
PRIDEⁱ	P11234
ProteomicsDBⁱ	52727

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5899
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000272519; ENSP00000272519; ENSG00000144118 [P11234-1] ENST00000420510; ENSP00000414224; ENSG00000144118 [P11234-1]
GeneIDⁱ	5899
KEGGⁱ	hsa:5899
UCSCⁱ	uc002tmk.4 human [P11234-1]

Organism-specific databases

CTDⁱ	5899
DisGeNETⁱ	5899
EuPathDBⁱ	HostDB:ENSG00000144118.13
GeneCardsⁱ	RALB
HGNCⁱ	HGNC:9840 RALB
HPAⁱ	CAB026010 HPA065232
MIMⁱ	179551 gene
neXtProtⁱ	NX_P11234
OpenTargetsⁱ	ENSG00000144118
PharmGKBⁱ	PA34198
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0395 Eukaryota COG1100 LUCA
GeneTreeⁱ	ENSGT00860000133672
HOGENOMⁱ	HOG000233973
HOVERGENⁱ	HBG009351
InParanoidⁱ	P11234
KOⁱ	K07835
OMAⁱ	ADEWGVQ
OrthoDBⁱ	EOG091G0UAU
PhylomeDBⁱ	P11234
TreeFamⁱ	TF312796

Enzyme and pathway databases

Reactomeⁱ	R-HSA-171007 p38MAPK events
SIGNORⁱ	P11234

Miscellaneous databases

ChiTaRSⁱ	RALB human
EvolutionaryTraceⁱ	P11234
GeneWikiⁱ	RALB
GenomeRNAiⁱ	5899
Protein Ontology More...PROⁱ	PR:P11234
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000144118 Expressed in 230 organ(s), highest expression level in frontal cortex
CleanExⁱ	HS_RALB
ExpressionAtlasⁱ	P11234 baseline and differential
Genevisibleⁱ	P11234 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR028412 Ral IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase IPR020849 Small_GTPase_Ras-type
PANTHERⁱ	PTHR24070 PTHR24070, 1 hit PTHR24070:SF199 PTHR24070:SF199, 1 hit
Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51421 RAS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RALB_HUMAN
Accessionⁱ	P11234Primary (citable) accession number: P11234 Secondary accession number(s): B4E040, Q53T32, Q6ZS74
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
	Last sequence update:	July 1, 1989
	Last modified:	November 7, 2018
	This is version 195 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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Supporting data

UniProtKB - P11234 (RALB_HUMAN)

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Ras-related protein Ral-B

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Extracellular region or secreted

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ