CHRM1

Functionⁱ

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

GO - Molecular functionⁱ

drug binding Source: Ensembl
G protein-coupled acetylcholine receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
G protein-coupled receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
G protein-coupled serotonin receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
neurotransmitter receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential Source: Ensembl
phosphatidylinositol phospholipase C activity
Source: ProtInc
Traceable author statementⁱ
- 9614217

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cell proliferation
Source: ProtInc
Traceable author statementⁱ
- 1905013
cellular protein modification process
Source: ProtInc
Traceable author statementⁱ
- 1411529
chemical synaptic transmission
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cognition Source: InterPro
G protein-coupled acetylcholine receptor signaling pathway
Source: ProtInc
Traceable author statementⁱ
- 8139539
G protein-coupled receptor signaling pathway Source: Reactome
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
nervous system development
Source: ProtInc
Traceable author statementⁱ
- 2739737
neuromuscular synaptic transmission Source: Ensembl
phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway
Source: ProtInc
Traceable author statementⁱ
- 8139539
positive regulation of cell proliferation
Source: ProtInc
Traceable author statementⁱ
- 2739737
positive regulation of intracellular protein transport Source: Ensembl
positive regulation of ion transport
Source: MGI
Inferred from genetic interactionⁱ
- 14657398
protein kinase C-activating G protein-coupled receptor signaling pathway
Source: ProtInc
Traceable author statementⁱ
- 9603968
regulation of locomotion Source: Ensembl
saliva secretion Source: InterPro
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 3443095
- 9614217

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactomeⁱ	R-HSA-390648 Muscarinic acetylcholine receptors R-HSA-416476 G alpha (q) signalling events

Reactomeⁱ

R-HSA-390648 Muscarinic acetylcholine receptors
R-HSA-416476 G alpha (q) signalling events

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Muscarinic acetylcholine receptor M1
Gene namesⁱ	Name:CHRM1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000168539.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1950 CHRM1
MIMⁱ	118510 gene
neXtProtⁱ	NX_P11229

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 24	ExtracellularSequence analysisAdd BLAST	24
Transmembraneⁱ	25 – 47	Helical; Name=1By similarityAdd BLAST	23
Topological domainⁱ	48 – 61	CytoplasmicSequence analysisAdd BLAST	14
Transmembraneⁱ	62 – 82	Helical; Name=2By similarityAdd BLAST	21
Topological domainⁱ	83 – 99	ExtracellularSequence analysisAdd BLAST	17
Transmembraneⁱ	100 – 121	Helical; Name=3By similarityAdd BLAST	22
Topological domainⁱ	122 – 141	CytoplasmicSequence analysisAdd BLAST	20
Transmembraneⁱ	142 – 164	Helical; Name=4By similarityAdd BLAST	23
Topological domainⁱ	165 – 186	ExtracellularSequence analysisAdd BLAST	22
Transmembraneⁱ	187 – 209	Helical; Name=5By similarityAdd BLAST	23
Topological domainⁱ	210 – 366	CytoplasmicSequence analysisAdd BLAST	157
Transmembraneⁱ	367 – 387	Helical; Name=6By similarityAdd BLAST	21
Topological domainⁱ	388 – 401	ExtracellularSequence analysisAdd BLAST	14
Transmembraneⁱ	402 – 421	Helical; Name=7By similarityAdd BLAST	20
Topological domainⁱ	422 – 460	CytoplasmicSequence analysisAdd BLAST	39

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1128
Open Targets More...OpenTargetsⁱ	ENSG00000168539
PharmGKBⁱ	PA26484

Chemistry databases

ChEMBLⁱ	CHEMBL216
Drug and drug target database More...DrugBankⁱ	DB08897 Aclidinium DB05766 ACP-104 DB05752 ALKS 27 DB00321 Amitriptyline DB00543 Amoxapine DB00517 Anisotropine Methylbromide DB04365 Arecoline DB01238 Aripiprazole DB00572 Atropine DB00245 Benzatropine DB00767 Benzquinamide DB00810 Biperiden DB00835 Brompheniramine DB00354 Buclizine DB00411 Carbachol DB00185 Cevimeline DB00477 Chlorpromazine DB01239 Chlorprothixene DB00568 Cinnarizine DB00215 Citalopram DB00771 Clidinium DB00363 Clozapine DB00907 Cocaine DB00785 Cryptenamine DB00979 Cyclopentolate DB00942 Cycrimine DB00434 Cyproheptadine DB00496 Darifenacin DB01151 Desipramine DB00804 Dicyclomine DB01231 Diphenidol DB00280 Disopyramide DB01142 Doxepin DB00366 Doxylamine DB01175 Escitalopram DB00392 Ethopropazine DB06702 Fesoterodine DB01148 Flavoxate DB00875 Flupentixol DB00986 Glycopyrronium DB00725 Homatropine Methylbromide DB00424 Hyoscyamine DB00458 Imipramine DB00332 Ipratropium bromide DB01221 Ketamine DB00408 Loxapine DB00934 Maprotiline DB04843 Mepenzolate DB00940 Methantheline DB01403 Methotrimeprazine DB00462 Methylscopolamine bromide DB00340 Metixene DB01233 Metoclopramide DB00805 Minaprine DB01618 Molindone DB05152 NGX267 DB00622 Nicardipine DB00540 Nortriptyline DB00334 Olanzapine DB01062 Oxybutynin DB00383 Oxyphencyclimine DB00219 Oxyphenonium DB00715 Paroxetine DB00454 Pethidine DB01085 Pilocarpine DB00670 Pirenzepine DB00387 Procyclidine DB00420 Promazine DB01069 Promethazine DB00782 Propantheline DB00777 Propiomazine DB01224 Quetiapine DB00747 Scopolamine DB01591 Solifenacin DB00202 Succinylcholine DB00342 Terfenadine DB01409 Tiotropium DB01036 Tolterodine DB00505 Tridihexethyl DB00508 Triflupromazine DB00376 Trihexyphenidyl DB00726 Trimipramine DB00809 Tropicamide DB00209 Trospium DB09076 Umeclidinium DB00246 Ziprasidone
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	13

Polymorphism and mutation databases

BioMutaⁱ	CHRM1
DMDMⁱ	113118

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000069015	1 – 460	Muscarinic acetylcholine receptor M1Add BLAST		460

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	2	N-linked (GlcNAc...) asparagineCurated	1
Glycosylationⁱ	12	N-linked (GlcNAc...) asparagineCurated	1
Disulfide bondⁱ	98 ↔ 178	PROSITE-ProRule annotation
Modified residueⁱ	230	PhosphothreonineBy similarity	1
Modified residueⁱ	428	PhosphothreonineSequence analysis	1
Modified residueⁱ	451	PhosphoserineSequence analysis	1
Modified residueⁱ	455	PhosphothreonineSequence analysis	1
Modified residueⁱ	457	PhosphoserineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	P11229
PeptideAtlas More...PeptideAtlasⁱ	P11229
PRIDEⁱ	P11229
ProteomicsDBⁱ	52724

PTM databases

iPTMnetⁱ	P11229
PhosphoSitePlusⁱ	P11229

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000168539 Expressed in 80 organ(s), highest expression level in anterior cingulate cortex
CleanExⁱ	HS_CHRM1
ExpressionAtlasⁱ	P11229 baseline and differential
Genevisibleⁱ	P11229 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB022366 HPA014101

HPAⁱ

CAB022366
HPA014101

Interactionⁱ

Subunit structureⁱ

Interacts with GPRASP2.1 Publication

Protein-protein interaction databases

BioGridⁱ	107550, 3 interactors
IntActⁱ	P11229, 5 interactors
Molecular INTeraction database More...MINTⁱ	P11229
STRINGⁱ	9606.ENSP00000306490

Chemistry databases

BindingDBⁱ

P11229

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	22 – 52	Combined sources	31
Helixⁱ	54 – 56	Combined sources	3
Helixⁱ	59 – 76	Combined sources	18
Helixⁱ	78 – 88	Combined sources	11
Helixⁱ	95 – 128	Combined sources	34
Turnⁱ	130 – 133	Combined sources	4
Helixⁱ	134 – 136	Combined sources	3
Helixⁱ	139 – 168	Combined sources	30
Helixⁱ	186 – 196	Combined sources	11
Helixⁱ	198 – 212	Combined sources	15
Helixⁱ	215 – 218	Combined sources	4
Helixⁱ	358 – 390	Combined sources	33
Beta strandⁱ	391 – 393	Combined sources	3
Helixⁱ	397 – 406	Combined sources	10
Helixⁱ	409 – 421	Combined sources	13
Helixⁱ	425 – 433	Combined sources	9

Show more details

3D structure databases

ProteinModelPortalⁱ	P11229
SMRⁱ	P11229
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM1 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG4220 Eukaryota ENOG410YCQR LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00780000121874
HOGENOMⁱ	HOG000231484
HOVERGENⁱ	HBG105720
InParanoidⁱ	P11229
KEGG Orthology (KO) More...KOⁱ	K04129
OMAⁱ	RCCRTPR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06VI
PhylomeDBⁱ	P11229
TreeFamⁱ	TF320495

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd15049 7tmA_mAChR, 1 hit
InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR002228 Musac_Ach_M1_rcpt IPR000995 Musac_Ach_rcpt
PANTHERⁱ	PTHR43914:SF7 PTHR43914:SF7, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR00243 MUSCARINICR PR00538 MUSCRINICM1R
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: P11229-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNTSAPPAVS PNITVLAPGK GPWQVAFIGI TTGLLSLATV TGNLLVLISF 
        60         70         80         90        100
KVNTELKTVN NYFLLSLACA DLIIGTFSMN LYTTYLLMGH WALGTLACDL 
       110        120        130        140        150
WLALDYVASN ASVMNLLLIS FDRYFSVTRP LSYRAKRTPR RAALMIGLAW 
       160        170        180        190        200
LVSFVLWAPA ILFWQYLVGE RTVLAGQCYI QFLSQPIITF GTAMAAFYLP 
       210        220        230        240        250
VTVMCTLYWR IYRETENRAR ELAALQGSET PGKGGGSSSS SERSQPGAEG 
       260        270        280        290        300
SPETPPGRCC RCCRAPRLLQ AYSWKEEEEE DEGSMESLTS SEGEEPGSEV 
       310        320        330        340        350
VIKMPMVDPE AQAPTKQPPR SSPNTVKRPT KKGRDRAGKG QKPRGKEQLA 
       360        370        380        390        400
KRKTFSLVKE KKAARTLSAI LLAFILTWTP YNIMVLVSTF CKDCVPETLW 
       410        420        430        440        450
ELGYWLCYVN STINPMCYAL CNKAFRDTFR LLLLCRWDKR RWRKIPKRPG 
       460
SVHRTPSRQC

Length:460

Mass (Da):51,421

Last modified:November 1, 1990 - v2

Checksum:ⁱ567C20F63541C8D0

GO

Isoform 2 (identifier: P11229-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
455-460: Missing.

« Hide

        10         20         30         40         50
MNTSAPPAVS PNITVLAPGK GPWQVAFIGI TTGLLSLATV TGNLLVLISF 
        60         70         80         90        100
KVNTELKTVN NYFLLSLACA DLIIGTFSMN LYTTYLLMGH WALGTLACDL 
       110        120        130        140        150
WLALDYVASN ASVMNLLLIS FDRYFSVTRP LSYRAKRTPR RAALMIGLAW 
       160        170        180        190        200
LVSFVLWAPA ILFWQYLVGE RTVLAGQCYI QFLSQPIITF GTAMAAFYLP 
       210        220        230        240        250
VTVMCTLYWR IYRETENRAR ELAALQGSET PGKGGGSSSS SERSQPGAEG 
       260        270        280        290        300
SPETPPGRCC RCCRAPRLLQ AYSWKEEEEE DEGSMESLTS SEGEEPGSEV 
       310        320        330        340        350
VIKMPMVDPE AQAPTKQPPR SSPNTVKRPT KKGRDRAGKG QKPRGKEQLA 
       360        370        380        390        400
KRKTFSLVKE KKAARTLSAI LLAFILTWTP YNIMVLVSTF CKDCVPETLW 
       410        420        430        440        450
ELGYWLCYVN STINPMCYAL CNKAFRDTFR LLLLCRWDKR RWRKIPKRPG 

SVHR

Note: No experimental confirmation available.

Show »

Length:454

Mass (Da):50,748

Checksum:ⁱ68D02A29898C8D92

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	F5GZF8	F5GZF8_HUMAN		Muscarinic acetylcholine receptor Muscarinic acetylcholine receptor	CHRM1	134	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	173	V → M in CAA33334 (PubMed:3443095).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056651	455 – 460	Missing in isoform 2. 1 Publication		6

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y00508 Genomic DNA Translation: CAA68560.1 X52068 Genomic DNA Translation: CAA36291.1 X15263 Genomic DNA Translation: CAA33334.1 AF385587 mRNA Translation: AAK68112.1 AF498915 mRNA Translation: AAM18938.1 AP000438 Genomic DNA No translation available. BC007740 mRNA Translation: AAH07740.1 BC022984 mRNA Translation: AAH22984.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8040.1 [P11229-1]
PIRⁱ	S09508
NCBI Reference Sequences More...RefSeqⁱ	NP_000729.2, NM_000738.2 [P11229-1] XP_011543044.1, XM_011544742.2 [P11229-1]
UniGeneⁱ	Hs.632119

Genome annotation databases

Ensemblⁱ	ENST00000306960; ENSP00000306490; ENSG00000168539 [P11229-1] ENST00000543973; ENSP00000441188; ENSG00000168539 [P11229-2]
GeneIDⁱ	1128
KEGGⁱ	hsa:1128
UCSC genome browser More...UCSCⁱ	uc058cqg.1 human [P11229-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P11229	Muscarinic acetylcholine receptor		HUMAN		460	UniRef100_P11229
Muscarinic acetylcholine receptor		PANTR		460
Muscarinic acetylcholine receptor		PONAB		460
Muscarinic acetylcholine receptor		COLAP		460
Muscarinic acetylcholine receptor		RHIRO		460
+6

Protein	Similar proteins		Species	Score	Length	Source
P11229	Muscarinic acetylcholine receptor M1		MACMU		460	UniRef90_P11229
Muscarinic acetylcholine receptor M1		MOUSE		460
Muscarinic acetylcholine receptor M1		PIG		460
Muscarinic acetylcholine receptor M1		PONAB		460
Muscarinic acetylcholine receptor M1		RAT		460
+105

Protein	Similar proteins		Species	Score	Length	Source
P11229	Muscarinic acetylcholine receptor M1		PIG		460	UniRef50_P11229
Muscarinic acetylcholine receptor M1		RAT		460
Muscarinic acetylcholine receptor M1		MACMU		460
Muscarinic acetylcholine receptor M1		MOUSE		460
Muscarinic acetylcholine receptor M1		PONAB		460
+115

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y00508 Genomic DNA Translation: CAA68560.1 X52068 Genomic DNA Translation: CAA36291.1 X15263 Genomic DNA Translation: CAA33334.1 AF385587 mRNA Translation: AAK68112.1 AF498915 mRNA Translation: AAM18938.1 AP000438 Genomic DNA No translation available. BC007740 mRNA Translation: AAH07740.1 BC022984 mRNA Translation: AAH22984.1
CCDSⁱ	CCDS8040.1 [P11229-1]
PIRⁱ	S09508
RefSeqⁱ	NP_000729.2, NM_000738.2 [P11229-1] XP_011543044.1, XM_011544742.2 [P11229-1]
UniGeneⁱ	Hs.632119

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5CXV	X-ray	2.70	A	2-218	[»]
				A	355-460	[»]
ProteinModelPortalⁱ	P11229
SMRⁱ	P11229
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107550, 3 interactors
IntActⁱ	P11229, 5 interactors
MINTⁱ	P11229
STRINGⁱ	9606.ENSP00000306490

Chemistry databases

BindingDBⁱ	P11229
ChEMBLⁱ	CHEMBL216
DrugBankⁱ	DB08897 Aclidinium DB05766 ACP-104 DB05752 ALKS 27 DB00321 Amitriptyline DB00543 Amoxapine DB00517 Anisotropine Methylbromide DB04365 Arecoline DB01238 Aripiprazole DB00572 Atropine DB00245 Benzatropine DB00767 Benzquinamide DB00810 Biperiden DB00835 Brompheniramine DB00354 Buclizine DB00411 Carbachol DB00185 Cevimeline DB00477 Chlorpromazine DB01239 Chlorprothixene DB00568 Cinnarizine DB00215 Citalopram DB00771 Clidinium DB00363 Clozapine DB00907 Cocaine DB00785 Cryptenamine DB00979 Cyclopentolate DB00942 Cycrimine DB00434 Cyproheptadine DB00496 Darifenacin DB01151 Desipramine DB00804 Dicyclomine DB01231 Diphenidol DB00280 Disopyramide DB01142 Doxepin DB00366 Doxylamine DB01175 Escitalopram DB00392 Ethopropazine DB06702 Fesoterodine DB01148 Flavoxate DB00875 Flupentixol DB00986 Glycopyrronium DB00725 Homatropine Methylbromide DB00424 Hyoscyamine DB00458 Imipramine DB00332 Ipratropium bromide DB01221 Ketamine DB00408 Loxapine DB00934 Maprotiline DB04843 Mepenzolate DB00940 Methantheline DB01403 Methotrimeprazine DB00462 Methylscopolamine bromide DB00340 Metixene DB01233 Metoclopramide DB00805 Minaprine DB01618 Molindone DB05152 NGX267 DB00622 Nicardipine DB00540 Nortriptyline DB00334 Olanzapine DB01062 Oxybutynin DB00383 Oxyphencyclimine DB00219 Oxyphenonium DB00715 Paroxetine DB00454 Pethidine DB01085 Pilocarpine DB00670 Pirenzepine DB00387 Procyclidine DB00420 Promazine DB01069 Promethazine DB00782 Propantheline DB00777 Propiomazine DB01224 Quetiapine DB00747 Scopolamine DB01591 Solifenacin DB00202 Succinylcholine DB00342 Terfenadine DB01409 Tiotropium DB01036 Tolterodine DB00505 Tridihexethyl DB00508 Triflupromazine DB00376 Trihexyphenidyl DB00726 Trimipramine DB00809 Tropicamide DB00209 Trospium DB09076 Umeclidinium DB00246 Ziprasidone
GuidetoPHARMACOLOGYⁱ	13

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

iPTMnetⁱ	P11229
PhosphoSitePlusⁱ	P11229

Polymorphism and mutation databases

BioMutaⁱ	CHRM1
DMDMⁱ	113118

Proteomic databases

PaxDbⁱ	P11229
PeptideAtlasⁱ	P11229
PRIDEⁱ	P11229
ProteomicsDBⁱ	52724

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1128
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000306960; ENSP00000306490; ENSG00000168539 [P11229-1] ENST00000543973; ENSP00000441188; ENSG00000168539 [P11229-2]
GeneIDⁱ	1128
KEGGⁱ	hsa:1128
UCSCⁱ	uc058cqg.1 human [P11229-1]

Organism-specific databases

CTDⁱ	1128
DisGeNETⁱ	1128
EuPathDBⁱ	HostDB:ENSG00000168539.3
GeneCardsⁱ	CHRM1
HGNCⁱ	HGNC:1950 CHRM1
HPAⁱ	CAB022366 HPA014101
MIMⁱ	118510 gene
neXtProtⁱ	NX_P11229
OpenTargetsⁱ	ENSG00000168539
PharmGKBⁱ	PA26484
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4220 Eukaryota ENOG410YCQR LUCA
GeneTreeⁱ	ENSGT00780000121874
HOGENOMⁱ	HOG000231484
HOVERGENⁱ	HBG105720
InParanoidⁱ	P11229
KOⁱ	K04129
OMAⁱ	RCCRTPR
OrthoDBⁱ	EOG091G06VI
PhylomeDBⁱ	P11229
TreeFamⁱ	TF320495

Enzyme and pathway databases

Reactomeⁱ	R-HSA-390648 Muscarinic acetylcholine receptors R-HSA-416476 G alpha (q) signalling events

Reactomeⁱ

R-HSA-390648 Muscarinic acetylcholine receptors
R-HSA-416476 G alpha (q) signalling events

Miscellaneous databases

GeneWikiⁱ	Muscarinic_acetylcholine_receptor_M1
GenomeRNAiⁱ	1128
Protein Ontology More...PROⁱ	PR:P11229
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000168539 Expressed in 80 organ(s), highest expression level in anterior cingulate cortex
CleanExⁱ	HS_CHRM1
ExpressionAtlasⁱ	P11229 baseline and differential
Genevisibleⁱ	P11229 HS

Family and domain databases

CDDⁱ	cd15049 7tmA_mAChR, 1 hit
InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR002228 Musac_Ach_M1_rcpt IPR000995 Musac_Ach_rcpt
PANTHERⁱ	PTHR43914:SF7 PTHR43914:SF7, 1 hit
Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR00243 MUSCARINICR PR00538 MUSCRINICM1R
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ACM1_HUMAN
Accessionⁱ	P11229Primary (citable) accession number: P11229 Secondary accession number(s): Q96RH1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
	Last sequence update:	November 1, 1990
	Last modified:	November 7, 2018
	This is version 191 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries

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UniProtKB - P11229 (ACM1_HUMAN)

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Muscarinic acetylcholine receptor M1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ