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UniProtKB - P11229 (ACM1_HUMAN)

Entry version 214 (25 May 2022)
Sequence version 2 (01 Nov 1990)
Previous versions | rss
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Protein

Muscarinic acetylcholine receptor M1

Gene

CHRM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei170Subtype-specific residue that binds to snake venom muscarinic toxin 71 Publication1
Sitei172Binds to snake venom muscarinic toxin 71 Publication1
Sitei174Subtype-specific residue that binds to snake venom muscarinic toxin 71 Publication1
Sitei397Subtype-specific residue that binds to snake venom muscarinic toxin 71 Publication1
Sitei401Subtype-specific residue that binds to snake venom muscarinic toxin 71 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P11229

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-390648, Muscarinic acetylcholine receptors
R-HSA-416476, G alpha (q) signalling events

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P11229

SIGNOR Signaling Network Open Resource

More...SIGNORi		P11229

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Muscarinic acetylcholine receptor M1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CHRM1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:1950, CHRM1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		118510, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P11229

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000168539

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 22ExtracellularCombined sources1 PublicationAdd BLAST22
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei23 – 48Helical; Name=1Combined sources1 PublicationAdd BLAST26
Topological domaini49 – 62CytoplasmicCombined sources1 PublicationAdd BLAST14
Transmembranei63 – 84Helical; Name=2Combined sources1 PublicationAdd BLAST22
Topological domaini85 – 95ExtracellularCombined sources1 PublicationAdd BLAST11
Transmembranei96 – 121Helical; Name=3Combined sources1 PublicationAdd BLAST26
Topological domaini122 – 142CytoplasmicCombined sources1 PublicationAdd BLAST21
Transmembranei143 – 164Helical; Name=4Combined sources1 PublicationAdd BLAST22
Topological domaini165 – 185ExtracellularCombined sources1 PublicationAdd BLAST21
Transmembranei186 – 209Helical; Name=5Combined sources1 PublicationAdd BLAST24
Topological domaini210 – 366CytoplasmicCombined sources1 PublicationAdd BLAST157
Transmembranei367 – 390Helical; Name=6Combined sources1 PublicationAdd BLAST24
Topological domaini391 – 397ExtracellularCombined sources1 Publication7
Transmembranei398 – 420Helical; Name=7Combined sources1 PublicationAdd BLAST23
Topological domaini421 – 460CytoplasmicCombined sources1 PublicationAdd BLAST40

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		1128

Open Targets

More...OpenTargetsi		ENSG00000168539

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26484

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P11229, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL216

Drug and drug target database

More...DrugBanki		DB03128, Acetylcholine
DB08897, Aclidinium
DB05766, ACP-104
DB05752, ALKS 27
DB00321, Amitriptyline
DB00543, Amoxapine
DB00517, Anisotropine methylbromide
DB04365, Arecoline
DB01238, Aripiprazole
DB14185, Aripiprazole lauroxil
DB00572, Atropine
DB00245, Benzatropine
DB00767, Benzquinamide
DB01019, Bethanechol
DB00810, Biperiden
DB00835, Brompheniramine
DB00354, Buclizine
DB00411, Carbamoylcholine
DB00185, Cevimeline
DB00477, Chlorpromazine
DB01239, Chlorprothixene
DB00568, Cinnarizine
DB00771, Clidinium
DB00363, Clozapine
DB00907, Cocaine
DB00979, Cyclopentolate
DB00942, Cycrimine
DB00434, Cyproheptadine
DB00496, Darifenacin
DB01151, Desipramine
DB00804, Dicyclomine
DB01231, Diphenidol
DB00280, Disopyramide
DB09167, Dosulepin
DB01142, Doxepin
DB00366, Doxylamine
DB01175, Escitalopram
DB09194, Etoperidone
DB06702, Fesoterodine
DB01148, Flavoxate
DB00875, Flupentixol
DB00483, Gallamine triethiodide
DB00986, Glycopyrronium
DB06787, Hexocyclium
DB11181, Homatropine
DB00725, Homatropine methylbromide
DB00424, Hyoscyamine
DB09262, Imidafenacin
DB00458, Imipramine
DB00332, Ipratropium
DB01221, Ketamine
DB00408, Loxapine
DB00934, Maprotiline
DB04843, Mepenzolate
DB00454, Meperidine
DB06709, Methacholine
DB00940, Methantheline
DB01403, Methotrimeprazine
DB00462, Methscopolamine bromide
DB00340, Metixene
DB01233, Metoclopramide
DB00805, Minaprine
DB01618, Molindone
DB05152, NGX267
DB00622, Nicardipine
DB00540, Nortriptyline
DB00334, Olanzapine
DB01062, Oxybutynin
DB00383, Oxyphencyclimine
DB00219, Oxyphenonium
DB00715, Paroxetine
DB01085, Pilocarpine
DB00670, Pirenzepine
DB06153, Pizotifen
DB00387, Procyclidine
DB00392, Profenamine
DB00420, Promazine
DB01069, Promethazine
DB00782, Propantheline
DB00777, Propiomazine
DB12278, Propiverine
DB11156, Pyrantel
DB01224, Quetiapine
DB11855, Revefenacin
DB13581, Rociverine
DB00747, Scopolamine
DB01591, Solifenacin
DB02010, Staurosporine
DB00342, Terfenadine
DB11235, Thonzylamine
DB01409, Tiotropium
DB01036, Tolterodine
DB00193, Tramadol
DB00505, Tridihexethyl
DB00508, Triflupromazine
DB00376, Trihexyphenidyl
DB09089, Trimebutine
DB00726, Trimipramine
DB00809, Tropicamide
DB00209, Trospium
DB09076, Umeclidinium
DB00246, Ziprasidone

DrugCentral

More...DrugCentrali		P11229

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		13

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CHRM1

Domain mapping of disease mutations (DMDM)

More...DMDMi		113118

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000690151 – 460Muscarinic acetylcholine receptor M1Add BLAST460

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi2N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi12N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi98 ↔ 178PROSITE-ProRule annotation
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei230PhosphothreonineBy similarity1
Modified residuei428PhosphothreonineSequence analysis1
Modified residuei451PhosphoserineSequence analysis1
Modified residuei455PhosphothreonineSequence analysis1
Modified residuei457PhosphoserineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P11229

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P11229

PeptideAtlas

More...PeptideAtlasi		P11229

PRoteomics IDEntifications database

More...PRIDEi		P11229

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		52724 [P11229-1]
77961

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P11229, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P11229

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P11229

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000168539, Expressed in anterior cingulate cortex and 100 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P11229, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P11229, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000168539, Group enriched (brain, prostate, salivary gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with GPRASP2 (PubMed:15086532).

Interacts with TMEM147 (PubMed:21056967).

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107550, 4 interactors

Protein interaction database and analysis system

More...IntActi		P11229, 5 interactors

Molecular INTeraction database

More...MINTi		P11229

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000306490

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P11229

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P11229, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1460
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P11229

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P11229

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni225 – 256DisorderedSequence analysisAdd BLAST32
Regioni274 – 297DisorderedSequence analysisAdd BLAST24
Regioni310 – 351DisorderedSequence analysisAdd BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi231 – 248Polar residuesSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM1 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4220, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162301

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_009579_11_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P11229

Identification of Orthologs from Complete Genome Data

More...OMAi		RCCRTPR

Database for complete collections of gene phylogenies

More...PhylomeDBi		P11229

TreeFam database of animal gene trees

More...TreeFami		TF320495

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
IPR002228, Musac_Ach_M1_rcpt
IPR000995, Musac_Ach_rcpt

The PANTHER Classification System

More...PANTHERi		PTHR24248:SF155, PTHR24248:SF155, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00001, 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00237, GPCRRHODOPSN
PR00243, MUSCARINICR
PR00538, MUSCRINICM1R

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P11229-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNTSAPPAVS PNITVLAPGK GPWQVAFIGI TTGLLSLATV TGNLLVLISF 
        60         70         80         90        100
KVNTELKTVN NYFLLSLACA DLIIGTFSMN LYTTYLLMGH WALGTLACDL 
       110        120        130        140        150
WLALDYVASN ASVMNLLLIS FDRYFSVTRP LSYRAKRTPR RAALMIGLAW 
       160        170        180        190        200
LVSFVLWAPA ILFWQYLVGE RTVLAGQCYI QFLSQPIITF GTAMAAFYLP 
       210        220        230        240        250
VTVMCTLYWR IYRETENRAR ELAALQGSET PGKGGGSSSS SERSQPGAEG 
       260        270        280        290        300
SPETPPGRCC RCCRAPRLLQ AYSWKEEEEE DEGSMESLTS SEGEEPGSEV 
       310        320        330        340        350
VIKMPMVDPE AQAPTKQPPR SSPNTVKRPT KKGRDRAGKG QKPRGKEQLA 
       360        370        380        390        400
KRKTFSLVKE KKAARTLSAI LLAFILTWTP YNIMVLVSTF CKDCVPETLW 
       410        420        430        440        450
ELGYWLCYVN STINPMCYAL CNKAFRDTFR LLLLCRWDKR RWRKIPKRPG 
       460
SVHRTPSRQC
Length:460
Mass (Da):51,421
Last modified:November 1, 1990 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i567C20F63541C8D0
GO
Isoform 2 (identifier: P11229-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     455-460: Missing.

Show »
Length:454
Mass (Da):50,748
Checksum:i68D02A29898C8D92
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5GZF8F5GZF8_HUMAN
Muscarinic acetylcholine receptor
CHRM1
134Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti173V → M in CAA33334 (PubMed:3443095).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_056651455 – 460Missing in isoform 2. 1 Publication6

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Y00508 Genomic DNA Translation: CAA68560.1
X52068 Genomic DNA Translation: CAA36291.1
X15263 Genomic DNA Translation: CAA33334.1
AF385587 mRNA Translation: AAK68112.1
AF498915 mRNA Translation: AAM18938.1
AP000438 Genomic DNA No translation available.
BC007740 mRNA Translation: AAH07740.1
BC022984 mRNA Translation: AAH22984.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS8040.1 [P11229-1]

Protein sequence database of the Protein Information Resource

More...PIRi		S09508

NCBI Reference Sequences

More...RefSeqi		NP_000729.2, NM_000738.2 [P11229-1]
XP_011543044.1, XM_011544742.2 [P11229-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000306960.4; ENSP00000306490.3; ENSG00000168539.4
ENST00000543973.1; ENSP00000441188.1; ENSG00000168539.4 [P11229-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1128

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1128

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000306960.4; ENSP00000306490.3; NM_000738.3; NP_000729.2

UCSC genome browser

More...UCSCi		uc058cqg.1, human [P11229-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00508 Genomic DNA Translation: CAA68560.1
X52068 Genomic DNA Translation: CAA36291.1
X15263 Genomic DNA Translation: CAA33334.1
AF385587 mRNA Translation: AAK68112.1
AF498915 mRNA Translation: AAM18938.1
AP000438 Genomic DNA No translation available.
BC007740 mRNA Translation: AAH07740.1
BC022984 mRNA Translation: AAH22984.1
CCDSiCCDS8040.1 [P11229-1]
PIRiS09508
RefSeqiNP_000729.2, NM_000738.2 [P11229-1]
XP_011543044.1, XM_011544742.2 [P11229-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5CXVX-ray2.70A2-218[»]
A355-460[»]
6OIJelectron microscopy3.30R2-460[»]
6WJCX-ray2.55A2-218[»]
A355-460[»]
6ZFZX-ray2.17A27-219[»]
A355-438[»]
6ZG4X-ray2.33A27-219[»]
A355-438[»]
6ZG9X-ray2.50A27-219[»]
A355-438[»]
AlphaFoldDBiP11229
SMRiP11229
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107550, 4 interactors
IntActiP11229, 5 interactors
MINTiP11229
STRINGi9606.ENSP00000306490

Chemistry databases

BindingDBiP11229
ChEMBLiCHEMBL216
DrugBankiDB03128, Acetylcholine
DB08897, Aclidinium
DB05766, ACP-104
DB05752, ALKS 27
DB00321, Amitriptyline
DB00543, Amoxapine
DB00517, Anisotropine methylbromide
DB04365, Arecoline
DB01238, Aripiprazole
DB14185, Aripiprazole lauroxil
DB00572, Atropine
DB00245, Benzatropine
DB00767, Benzquinamide
DB01019, Bethanechol
DB00810, Biperiden
DB00835, Brompheniramine
DB00354, Buclizine
DB00411, Carbamoylcholine
DB00185, Cevimeline
DB00477, Chlorpromazine
DB01239, Chlorprothixene
DB00568, Cinnarizine
DB00771, Clidinium
DB00363, Clozapine
DB00907, Cocaine
DB00979, Cyclopentolate
DB00942, Cycrimine
DB00434, Cyproheptadine
DB00496, Darifenacin
DB01151, Desipramine
DB00804, Dicyclomine
DB01231, Diphenidol
DB00280, Disopyramide
DB09167, Dosulepin
DB01142, Doxepin
DB00366, Doxylamine
DB01175, Escitalopram
DB09194, Etoperidone
DB06702, Fesoterodine
DB01148, Flavoxate
DB00875, Flupentixol
DB00483, Gallamine triethiodide
DB00986, Glycopyrronium
DB06787, Hexocyclium
DB11181, Homatropine
DB00725, Homatropine methylbromide
DB00424, Hyoscyamine
DB09262, Imidafenacin
DB00458, Imipramine
DB00332, Ipratropium
DB01221, Ketamine
DB00408, Loxapine
DB00934, Maprotiline
DB04843, Mepenzolate
DB00454, Meperidine
DB06709, Methacholine
DB00940, Methantheline
DB01403, Methotrimeprazine
DB00462, Methscopolamine bromide
DB00340, Metixene
DB01233, Metoclopramide
DB00805, Minaprine
DB01618, Molindone
DB05152, NGX267
DB00622, Nicardipine
DB00540, Nortriptyline
DB00334, Olanzapine
DB01062, Oxybutynin
DB00383, Oxyphencyclimine
DB00219, Oxyphenonium
DB00715, Paroxetine
DB01085, Pilocarpine
DB00670, Pirenzepine
DB06153, Pizotifen
DB00387, Procyclidine
DB00392, Profenamine
DB00420, Promazine
DB01069, Promethazine
DB00782, Propantheline
DB00777, Propiomazine
DB12278, Propiverine
DB11156, Pyrantel
DB01224, Quetiapine
DB11855, Revefenacin
DB13581, Rociverine
DB00747, Scopolamine
DB01591, Solifenacin
DB02010, Staurosporine
DB00342, Terfenadine
DB11235, Thonzylamine
DB01409, Tiotropium
DB01036, Tolterodine
DB00193, Tramadol
DB00505, Tridihexethyl
DB00508, Triflupromazine
DB00376, Trihexyphenidyl
DB09089, Trimebutine
DB00726, Trimipramine
DB00809, Tropicamide
DB00209, Trospium
DB09076, Umeclidinium
DB00246, Ziprasidone
DrugCentraliP11229
GuidetoPHARMACOLOGYi13

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

GlyGeniP11229, 2 sites
iPTMnetiP11229
PhosphoSitePlusiP11229

Genetic variation databases

BioMutaiCHRM1
DMDMi113118

Proteomic databases

MassIVEiP11229
PaxDbiP11229
PeptideAtlasiP11229
PRIDEiP11229
ProteomicsDBi52724 [P11229-1]
77961

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P11229, 12 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2948, 325 antibodies from 37 providers

The DNASU plasmid repository

More...DNASUi		1128

Genome annotation databases

EnsembliENST00000306960.4; ENSP00000306490.3; ENSG00000168539.4
ENST00000543973.1; ENSP00000441188.1; ENSG00000168539.4 [P11229-2]
GeneIDi1128
KEGGihsa:1128
MANE-SelectiENST00000306960.4; ENSP00000306490.3; NM_000738.3; NP_000729.2
UCSCiuc058cqg.1, human [P11229-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1128
DisGeNETi1128

GeneCards: human genes, protein and diseases

More...GeneCardsi		CHRM1
HGNCiHGNC:1950, CHRM1
HPAiENSG00000168539, Group enriched (brain, prostate, salivary gland)
MIMi118510, gene
neXtProtiNX_P11229
OpenTargetsiENSG00000168539
PharmGKBiPA26484
VEuPathDBiHostDB:ENSG00000168539

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4220, Eukaryota
GeneTreeiENSGT00940000162301
HOGENOMiCLU_009579_11_2_1
InParanoidiP11229
OMAiRCCRTPR
PhylomeDBiP11229
TreeFamiTF320495

Enzyme and pathway databases

PathwayCommonsiP11229
ReactomeiR-HSA-390648, Muscarinic acetylcholine receptors
R-HSA-416476, G alpha (q) signalling events
SignaLinkiP11229
SIGNORiP11229

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1128, 15 hits in 1073 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CHRM1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Muscarinic_acetylcholine_receptor_M1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1128
PharosiP11229, Tclin

Protein Ontology

More...PROi		PR:P11229
RNActiP11229, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000168539, Expressed in anterior cingulate cortex and 100 other tissues
ExpressionAtlasiP11229, baseline and differential
GenevisibleiP11229, HS

Family and domain databases

InterProiView protein in InterPro
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
IPR002228, Musac_Ach_M1_rcpt
IPR000995, Musac_Ach_rcpt
PANTHERiPTHR24248:SF155, PTHR24248:SF155, 1 hit
PfamiView protein in Pfam
PF00001, 7tm_1, 1 hit
PRINTSiPR00237, GPCRRHODOPSN
PR00243, MUSCARINICR
PR00538, MUSCRINICM1R
PROSITEiView protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiACM1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P11229
Secondary accession number(s): Q96RH1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1990
Last modified: May 25, 2022
This is version 214 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
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