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Protein

Mannose-binding protein C

Gene

MBL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA.1 Publication

GO - Molecular functioni

  • calcium-dependent protein binding Source: UniProtKB
  • calcium ion binding Source: GO_Central
  • mannose binding Source: BHF-UCL
  • serine-type endopeptidase activity Source: Reactome
  • signaling receptor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processComplement activation lectin pathway, Complement pathway, Immunity, Innate immunity
LigandCalcium, Lectin, Mannose-binding

Enzyme and pathway databases

ReactomeiR-HSA-166662 Lectin pathway of complement activation
R-HSA-166663 Initial triggering of complement

Protein family/group databases

UniLectiniP11226

Names & Taxonomyi

Protein namesi
Recommended name:
Mannose-binding protein C
Short name:
MBP-C
Alternative name(s):
Collectin-1
MBP1
Mannan-binding protein
Mannose-binding lectin
Gene namesi
Name:MBL2
Synonyms:COLEC1, MBL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000165471.6
HGNCiHGNC:6922 MBL2
MIMi154545 gene
neXtProtiNX_P11226

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi4153
MalaCardsiMBL2
MIMi610424 phenotype
614372 phenotype
OpenTargetsiENSG00000165471
PharmGKBiPA30665

Chemistry databases

ChEMBLiCHEMBL1795113
DrugBankiDB03879 alpha-L-methyl-fucose
DB04426 Alpha-Methyl-N-Acetyl-D-Glucosamine
DB03194 beta-L-methyl-fucose
DB01979 Methyl alpha-D-mannoside
DB03721 N-acetyl-alpha-neuraminic acid
DB01818 O3-Sulfonylgalactose
DB02837 O4-Sulfonylgalactose

Polymorphism and mutation databases

BioMutaiMBL2
DMDMi126676

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 201 PublicationAdd BLAST20
ChainiPRO_000001740121 – 248Mannose-binding protein CAdd BLAST228

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei47Hydroxyproline1 Publication1
Modified residuei73Hydroxyproline1 Publication1
Modified residuei79Hydroxyproline1 Publication1
Modified residuei82Hydroxyproline1 Publication1
Modified residuei88Hydroxyproline1 Publication1
Disulfide bondi155 ↔ 244
Disulfide bondi222 ↔ 236

Keywords - PTMi

Disulfide bond, Hydroxylation

Proteomic databases

PaxDbiP11226
PeptideAtlasiP11226
PRIDEiP11226
ProteomicsDBi52723
TopDownProteomicsiP11226

PTM databases

iPTMnetiP11226
PhosphoSitePlusiP11226

Miscellaneous databases

PMAP-CutDBiP11226

Expressioni

Tissue specificityi

Plasma protein produced mainly in the liver.1 Publication

Gene expression databases

BgeeiENSG00000165471 Expressed in 24 organ(s), highest expression level in liver
CleanExiHS_MBL2
GenevisibleiP11226 HS

Organism-specific databases

HPAiCAB016782
HPA002027

Interactioni

Subunit structurei

Oligomeric complex of 3 or more homotrimers. Interacts with MASP1 and MASP2. Interacts with MEP1A and MEP1B and may inhibit their catalytic activity.3 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110323, 6 interactors
DIPiDIP-61381N
IntActiP11226, 6 interactors
MINTiP11226
STRINGi9606.ENSP00000363079

Structurei

Secondary structure

1248
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP11226
SMRiP11226
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP11226

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 99Collagen-likeAdd BLAST58
Domaini134 – 245C-type lectinPROSITE-ProRule annotationAdd BLAST112

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili112 – 1301 PublicationAdd BLAST19

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi21 – 41Cys-richAdd BLAST21

Domaini

The coiled-coil domain mediates trimerization.

Keywords - Domaini

Coiled coil, Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IS38 Eukaryota
ENOG410YQHR LUCA
GeneTreeiENSGT00700000104102
HOVERGENiHBG108270
InParanoidiP11226
KOiK03991
OMAiYSETVTC
OrthoDBiEOG091G0R93
PhylomeDBiP11226
TreeFamiTF330481

Family and domain databases

CDDicd03591 CLECT_collectin_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR008160 Collagen
IPR033990 Collectin_CTLD
IPR016187 CTDL_fold
IPR037570 Mannose-binding_protein
PANTHERiPTHR24020:SF0 PTHR24020:SF0, 1 hit
PfamiView protein in Pfam
PF01391 Collagen, 1 hit
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11226-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLFPSLPLL LLSMVAASYS ETVTCEDAQK TCPAVIACSS PGINGFPGKD
60 70 80 90 100
GRDGTKGEKG EPGQGLRGLQ GPPGKLGPPG NPGPSGSPGP KGQKGDPGKS
110 120 130 140 150
PDGDSSLAAS ERKALQTEMA RIKKWLTFSL GKQVGNKFFL TNGEIMTFEK
160 170 180 190 200
VKALCVKFQA SVATPRNAAE NGAIQNLIKE EAFLGITDEK TEGQFVDLTG
210 220 230 240
NRLTYTNWNE GEPNNAGSDE DCVLLLKNGQ WNDVPCSTSH LAVCEFPI
Length:248
Mass (Da):26,144
Last modified:April 1, 1990 - v2
Checksum:iC1F2AAED46D0F774
GO

Polymorphismi

Genetic variations in MBL2 influence susceptibility to hepatitis B virus (HBV) infection [MIMi:610424].
Genetic variations in MBL2 are responsible for mannose-binding protein deficiency [MIMi:614372]. This condition is defined as MBL2 protein level of less than 100 ng/ml, is present in about 5% of people of European descent and in about 10% of sub-Saharan Africans. Most MBL2-deficient adults appear healthy, but low levels of MBL2 are associated with increased risk of infection in toddlers, in cancer patients undergoing chemotherapy, and in organ-transplant patients receiving immunosuppressive drugs, particularly recipients of liver transplants. There is an association between low levels of MBL2 and a defect of opsonization which results in susceptibility to frequent and chronic infections (PubMed:1675710). Functional MBL2 deficiency may be associated with protection against tuberculosis caused by Mycobacterium africanum but not by Mycobacterium tuberculosis, as observed in studies on Ghanaian patients with pulmonary tuberculosis (PubMed:21695215).2 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01329424T → A in Chinese. 1 Publication1
Natural variantiVAR_00854352R → C in 0.05% of European and African populations. 3 PublicationsCorresponds to variant dbSNP:rs5030737EnsemblClinVar.1
Natural variantiVAR_00418254G → D Polymorphism; associated with low serum mannose-binding protein (MBP) concentrations and recurrent infections. 8 PublicationsCorresponds to variant dbSNP:rs1800450EnsemblClinVar.1
Natural variantiVAR_00418357G → E Polymorphism; associated with low serum mannose-binding protein (MBP) concentrations; associated with protection against tuberculosis caused by Mycobacterium africanum. 5 PublicationsCorresponds to variant dbSNP:rs1800451EnsemblClinVar.1
Natural variantiVAR_050119214N → Y. Corresponds to variant dbSNP:rs12260094Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15422 mRNA Translation: CAA33462.1
X15954
, X15955, X15956, X15957 Genomic DNA Translation: CAA34079.1
AF080510, AF080508, AF080509 Genomic DNA Translation: AAC31937.1
Y16576 Genomic DNA Translation: CAB56044.1
Y16577 Genomic DNA Translation: CAB56120.1
Y16578 Genomic DNA Translation: CAB56045.1
Y16579 Genomic DNA Translation: CAB56121.1
Y16580 Genomic DNA Translation: CAB56122.1
Y16581 Genomic DNA Translation: CAB56123.1
Y16582 Genomic DNA Translation: CAB56124.1
AF360991 mRNA Translation: AAK52907.1
AY826184 mRNA Translation: AAV80468.1
DQ217939 Genomic DNA Translation: ABB01009.1
EU596574 Genomic DNA Translation: ACC62880.1
CH471083 Genomic DNA Translation: EAW54148.1
CH471083 Genomic DNA Translation: EAW54149.1
BC096179 mRNA Translation: AAH96179.1
BC096180 mRNA Translation: AAH96180.3
BC069338 mRNA Translation: AAH69338.1
BC096181 mRNA Translation: AAH96181.3
BC096182 mRNA Translation: AAH96182.3
AF482699 Genomic DNA Translation: AAN39274.1
AF482700 Genomic DNA Translation: AAN39275.1
CCDSiCCDS7247.1
PIRiJL0115 LNHUMC
RefSeqiNP_000233.1, NM_000242.2
XP_006717924.1, XM_006717861.3
XP_011538118.1, XM_011539816.2
UniGeneiHs.499674

Genome annotation databases

EnsembliENST00000373968; ENSP00000363079; ENSG00000165471
GeneIDi4153
KEGGihsa:4153
UCSCiuc001jjt.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Mannose-binding protein

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15422 mRNA Translation: CAA33462.1
X15954
, X15955, X15956, X15957 Genomic DNA Translation: CAA34079.1
AF080510, AF080508, AF080509 Genomic DNA Translation: AAC31937.1
Y16576 Genomic DNA Translation: CAB56044.1
Y16577 Genomic DNA Translation: CAB56120.1
Y16578 Genomic DNA Translation: CAB56045.1
Y16579 Genomic DNA Translation: CAB56121.1
Y16580 Genomic DNA Translation: CAB56122.1
Y16581 Genomic DNA Translation: CAB56123.1
Y16582 Genomic DNA Translation: CAB56124.1
AF360991 mRNA Translation: AAK52907.1
AY826184 mRNA Translation: AAV80468.1
DQ217939 Genomic DNA Translation: ABB01009.1
EU596574 Genomic DNA Translation: ACC62880.1
CH471083 Genomic DNA Translation: EAW54148.1
CH471083 Genomic DNA Translation: EAW54149.1
BC096179 mRNA Translation: AAH96179.1
BC096180 mRNA Translation: AAH96180.3
BC069338 mRNA Translation: AAH69338.1
BC096181 mRNA Translation: AAH96181.3
BC096182 mRNA Translation: AAH96182.3
AF482699 Genomic DNA Translation: AAN39274.1
AF482700 Genomic DNA Translation: AAN39275.1
CCDSiCCDS7247.1
PIRiJL0115 LNHUMC
RefSeqiNP_000233.1, NM_000242.2
XP_006717924.1, XM_006717861.3
XP_011538118.1, XM_011539816.2
UniGeneiHs.499674

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HUPX-ray2.50A108-248[»]
ProteinModelPortaliP11226
SMRiP11226
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110323, 6 interactors
DIPiDIP-61381N
IntActiP11226, 6 interactors
MINTiP11226
STRINGi9606.ENSP00000363079

Chemistry databases

ChEMBLiCHEMBL1795113
DrugBankiDB03879 alpha-L-methyl-fucose
DB04426 Alpha-Methyl-N-Acetyl-D-Glucosamine
DB03194 beta-L-methyl-fucose
DB01979 Methyl alpha-D-mannoside
DB03721 N-acetyl-alpha-neuraminic acid
DB01818 O3-Sulfonylgalactose
DB02837 O4-Sulfonylgalactose

Protein family/group databases

UniLectiniP11226

PTM databases

iPTMnetiP11226
PhosphoSitePlusiP11226

Polymorphism and mutation databases

BioMutaiMBL2
DMDMi126676

Proteomic databases

PaxDbiP11226
PeptideAtlasiP11226
PRIDEiP11226
ProteomicsDBi52723
TopDownProteomicsiP11226

Protocols and materials databases

DNASUi4153
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373968; ENSP00000363079; ENSG00000165471
GeneIDi4153
KEGGihsa:4153
UCSCiuc001jjt.3 human

Organism-specific databases

CTDi4153
DisGeNETi4153
EuPathDBiHostDB:ENSG00000165471.6
GeneCardsiMBL2
HGNCiHGNC:6922 MBL2
HPAiCAB016782
HPA002027
MalaCardsiMBL2
MIMi154545 gene
610424 phenotype
614372 phenotype
neXtProtiNX_P11226
OpenTargetsiENSG00000165471
PharmGKBiPA30665
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IS38 Eukaryota
ENOG410YQHR LUCA
GeneTreeiENSGT00700000104102
HOVERGENiHBG108270
InParanoidiP11226
KOiK03991
OMAiYSETVTC
OrthoDBiEOG091G0R93
PhylomeDBiP11226
TreeFamiTF330481

Enzyme and pathway databases

ReactomeiR-HSA-166662 Lectin pathway of complement activation
R-HSA-166663 Initial triggering of complement

Miscellaneous databases

EvolutionaryTraceiP11226
GeneWikiiMannan-binding_lectin
GenomeRNAii4153
PMAP-CutDBiP11226
PROiPR:P11226
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000165471 Expressed in 24 organ(s), highest expression level in liver
CleanExiHS_MBL2
GenevisibleiP11226 HS

Family and domain databases

CDDicd03591 CLECT_collectin_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR008160 Collagen
IPR033990 Collectin_CTLD
IPR016187 CTDL_fold
IPR037570 Mannose-binding_protein
PANTHERiPTHR24020:SF0 PTHR24020:SF0, 1 hit
PfamiView protein in Pfam
PF01391 Collagen, 1 hit
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMBL2_HUMAN
AccessioniPrimary (citable) accession number: P11226
Secondary accession number(s): Q4VB12
, Q4VB13, Q4VB14, Q5SQS3, Q86SI4, Q96KE4, Q96TF7, Q96TF8, Q96TF9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: April 1, 1990
Last modified: September 12, 2018
This is version 214 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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