MBL2

Functionⁱ

Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA.1 Publication

GO - Molecular functionⁱ

calcium-dependent protein binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 12421953
- 18596036
calcium ion binding Source: GO_Central
mannose binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 23544079
serine-type endopeptidase activity Source: Reactome
signaling receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 11549596

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

acute-phase response
Source: BHF-UCL
Traceable author statementⁱ
- 2477488
complement activation Source: Reactome
complement activation, classical pathway Source: UniProtKB-KW
complement activation, lectin pathway
Source: MGI
Inferred from direct assayⁱ
- 15148336
defense response to bacterium
Source: BHF-UCL
Traceable author statementⁱ
- 2477488
defense response to Gram-positive bacterium
Source: MGI
Inferred from direct assayⁱ
- 15148336
innate immune response
Source: BHF-UCL
Inferred from direct assayⁱ
- 23544079
killing by host of symbiont cells Source: Ensembl
negative regulation of growth of symbiont in host
Source: MGI
Inferred from direct assayⁱ
- 15148336
negative regulation of viral process
Source: BHF-UCL
Inferred from direct assayⁱ
- 23544079
opsonization
Source: BHF-UCL
Traceable author statementⁱ
- 2477488
positive regulation of phagocytosis Source: Ensembl
response to oxidative stress
Source: UniProtKB
Non-traceable author statementⁱ
- 11549596

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Complement activation lectin pathway, Complement pathway, Immunity, Innate immunity
Ligand	Calcium, Lectin, Mannose-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-166662 Lectin pathway of complement activation R-HSA-166663 Initial triggering of complement

Reactomeⁱ

R-HSA-166662 Lectin pathway of complement activation
R-HSA-166663 Initial triggering of complement

Protein family/group databases

UniLectinⁱ	P11226

UniLectinⁱ

P11226

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Mannose-binding protein C Short name: MBP-C Alternative name(s): Collectin-1 MBP1 Mannan-binding protein Mannose-binding lectin
Gene namesⁱ	Name:MBL2 Synonyms:COLEC1, MBL
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000165471.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6922 MBL2
MIMⁱ	154545 gene
neXtProtⁱ	NX_P11226

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4153
MalaCards human disease database More...MalaCardsⁱ	MBL2
MIMⁱ	610424 phenotype 614372 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000165471
PharmGKBⁱ	PA30665

Chemistry databases

ChEMBLⁱ	CHEMBL1795113
Drug and drug target database More...DrugBankⁱ	DB03879 alpha-L-methyl-fucose DB04426 Alpha-Methyl-N-Acetyl-D-Glucosamine DB03194 beta-L-methyl-fucose DB01979 Methyl alpha-D-mannoside DB03721 N-acetyl-alpha-neuraminic acid DB01818 O3-Sulfonylgalactose DB02837 O4-Sulfonylgalactose

Polymorphism and mutation databases

BioMutaⁱ	MBL2
DMDMⁱ	126676

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 20	1 PublicationAdd BLAST		20
ChainⁱPRO_0000017401	21 – 248	Mannose-binding protein CAdd BLAST		228

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	47	Hydroxyproline1 Publication	1
Modified residueⁱ	73	Hydroxyproline1 Publication	1
Modified residueⁱ	79	Hydroxyproline1 Publication	1
Modified residueⁱ	82	Hydroxyproline1 Publication	1
Modified residueⁱ	88	Hydroxyproline1 Publication	1
Disulfide bondⁱ	155 ↔ 244
Disulfide bondⁱ	222 ↔ 236

Keywords - PTMⁱ

Disulfide bond, Hydroxylation

Proteomic databases

PaxDbⁱ	P11226
PeptideAtlas More...PeptideAtlasⁱ	P11226
PRIDEⁱ	P11226
ProteomicsDBⁱ	52723
TopDownProteomicsⁱ	P11226

PTM databases

iPTMnetⁱ	P11226
PhosphoSitePlusⁱ	P11226

Miscellaneous databases

PMAP-CutDBⁱ	P11226

PMAP-CutDBⁱ

P11226

Expressionⁱ

Tissue specificityⁱ

Plasma protein produced mainly in the liver.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000165471 Expressed in 24 organ(s), highest expression level in liver
CleanExⁱ	HS_MBL2
Genevisibleⁱ	P11226 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB016782 HPA002027

HPAⁱ

CAB016782
HPA002027

Interactionⁱ

Subunit structureⁱ

Oligomeric complex of 3 or more homotrimers. Interacts with MASP1 and MASP2. Interacts with MEP1A and MEP1B and may inhibit their catalytic activity.3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
LRP1	Q07954	5	EBI-5325353,EBI-1046087
MASP1	P48740-1	3	EBI-5325353,EBI-16138717

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	110323, 6 interactors
Database of interacting proteins More...DIPⁱ	DIP-61381N
IntActⁱ	P11226, 6 interactors
Molecular INTeraction database More...MINTⁱ	P11226
STRINGⁱ	9606.ENSP00000363079

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	110 – 129	Combined sources	20
Beta strandⁱ	131 – 134	Combined sources	4
Beta strandⁱ	137 – 147	Combined sources	11
Helixⁱ	148 – 157	Combined sources	10
Helixⁱ	168 – 177	Combined sources	10
Beta strandⁱ	182 – 187	Combined sources	6
Beta strandⁱ	189 – 191	Combined sources	3
Helixⁱ	216 – 218	Combined sources	3
Beta strandⁱ	222 – 225	Combined sources	4
Beta strandⁱ	231 – 234	Combined sources	4
Beta strandⁱ	238 – 247	Combined sources	10

Show more details

3D structure databases

ProteinModelPortalⁱ	P11226
SMRⁱ	P11226
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P11226

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	42 – 99	Collagen-likeAdd BLAST		58
Domainⁱ	134 – 245	C-type lectinPROSITE-ProRule annotationAdd BLAST		112

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	112 – 130	1 PublicationAdd BLAST		19

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	21 – 41	Cys-richAdd BLAST		21

Domainⁱ

The coiled-coil domain mediates trimerization.

Keywords - Domainⁱ

Coiled coil, Collagen, Repeat, Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IS38 Eukaryota ENOG410YQHR LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00700000104102
HOVERGENⁱ	HBG108270
InParanoidⁱ	P11226
KEGG Orthology (KO) More...KOⁱ	K03991
OMAⁱ	YSETVTC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0R93
PhylomeDBⁱ	P11226
TreeFamⁱ	TF330481

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd03591 CLECT_collectin_like, 1 hit
Gene3Dⁱ	3.10.100.10, 1 hit
InterProⁱ	View protein in InterPro IPR001304 C-type_lectin-like IPR016186 C-type_lectin-like/link_sf IPR018378 C-type_lectin_CS IPR008160 Collagen IPR033990 Collectin_CTLD IPR016187 CTDL_fold IPR037570 Mannose-binding_protein
PANTHERⁱ	PTHR24020:SF0 PTHR24020:SF0, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01391 Collagen, 1 hit PF00059 Lectin_C, 1 hit
SMARTⁱ	View protein in SMART SM00034 CLECT, 1 hit
SUPFAMⁱ	SSF56436 SSF56436, 1 hit
PROSITEⁱ	View protein in PROSITE PS00615 C_TYPE_LECTIN_1, 1 hit PS50041 C_TYPE_LECTIN_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P11226-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSLFPSLPLL LLSMVAASYS ETVTCEDAQK TCPAVIACSS PGINGFPGKD 
        60         70         80         90        100
GRDGTKGEKG EPGQGLRGLQ GPPGKLGPPG NPGPSGSPGP KGQKGDPGKS 
       110        120        130        140        150
PDGDSSLAAS ERKALQTEMA RIKKWLTFSL GKQVGNKFFL TNGEIMTFEK 
       160        170        180        190        200
VKALCVKFQA SVATPRNAAE NGAIQNLIKE EAFLGITDEK TEGQFVDLTG 
       210        220        230        240 
NRLTYTNWNE GEPNNAGSDE DCVLLLKNGQ WNDVPCSTSH LAVCEFPI

Length:248

Mass (Da):26,144

Last modified:April 1, 1990 - v2

Checksum:ⁱC1F2AAED46D0F774

GO

Polymorphismⁱ

Genetic variations in MBL2 influence susceptibility to hepatitis B virus (HBV) infection [MIMⁱ:610424].

Genetic variations in MBL2 are responsible for mannose-binding protein deficiency [MIMⁱ:614372]. This condition is defined as MBL2 protein level of less than 100 ng/ml, is present in about 5% of people of European descent and in about 10% of sub-Saharan Africans. Most MBL2-deficient adults appear healthy, but low levels of MBL2 are associated with increased risk of infection in toddlers, in cancer patients undergoing chemotherapy, and in organ-transplant patients receiving immunosuppressive drugs, particularly recipients of liver transplants. There is an association between low levels of MBL2 and a defect of opsonization which results in susceptibility to frequent and chronic infections (PubMed:1675710). Functional MBL2 deficiency may be associated with protection against tuberculosis caused by Mycobacterium africanum but not by Mycobacterium tuberculosis, as observed in studies on Ghanaian patients with pulmonary tuberculosis (PubMed:21695215).2 Publications

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_013294	24	T → A in Chinese. 1 Publication	1
Natural variantⁱVAR_008543	52	R → C in 0.05% of European and African populations. 3 PublicationsCorresponds to variant dbSNP:rs5030737EnsemblClinVar.	1
Natural variantⁱVAR_004182	54	G → D Polymorphism; associated with low serum mannose-binding protein (MBP) concentrations and recurrent infections. 8 PublicationsCorresponds to variant dbSNP:rs1800450EnsemblClinVar.	1
Natural variantⁱVAR_004183	57	G → E Polymorphism; associated with low serum mannose-binding protein (MBP) concentrations; associated with protection against tuberculosis caused by Mycobacterium africanum. 5 PublicationsCorresponds to variant dbSNP:rs1800451EnsemblClinVar.	1
Natural variantⁱVAR_050119	214	N → Y. Corresponds to variant dbSNP:rs12260094Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X15422 mRNA Translation: CAA33462.1 X15954 , X15955, X15956, X15957 Genomic DNA Translation: CAA34079.1 AF080510, AF080508, AF080509 Genomic DNA Translation: AAC31937.1 Y16576 Genomic DNA Translation: CAB56044.1 Y16577 Genomic DNA Translation: CAB56120.1 Y16578 Genomic DNA Translation: CAB56045.1 Y16579 Genomic DNA Translation: CAB56121.1 Y16580 Genomic DNA Translation: CAB56122.1 Y16581 Genomic DNA Translation: CAB56123.1 Y16582 Genomic DNA Translation: CAB56124.1 AF360991 mRNA Translation: AAK52907.1 AY826184 mRNA Translation: AAV80468.1 DQ217939 Genomic DNA Translation: ABB01009.1 EU596574 Genomic DNA Translation: ACC62880.1 CH471083 Genomic DNA Translation: EAW54148.1 CH471083 Genomic DNA Translation: EAW54149.1 BC096179 mRNA Translation: AAH96179.1 BC096180 mRNA Translation: AAH96180.3 BC069338 mRNA Translation: AAH69338.1 BC096181 mRNA Translation: AAH96181.3 BC096182 mRNA Translation: AAH96182.3 AF482699 Genomic DNA Translation: AAN39274.1 AF482700 Genomic DNA Translation: AAN39275.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS7247.1
PIRⁱ	JL0115 LNHUMC
NCBI Reference Sequences More...RefSeqⁱ	NP_000233.1, NM_000242.2 XP_006717924.1, XM_006717861.3 XP_011538118.1, XM_011539816.2
UniGeneⁱ	Hs.499674

Genome annotation databases

Ensemblⁱ	ENST00000373968; ENSP00000363079; ENSG00000165471
GeneIDⁱ	4153
KEGGⁱ	hsa:4153
UCSC genome browser More...UCSCⁱ	uc001jjt.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P11226	Mannose-binding protein C		GORGO		248	UniRef90_P11226
Mannose-binding protein C		HYLLA		248
Mannose-binding protein C		NOMCO		248
Mannose-binding protein C		PANTR		248
Mannose-binding protein C		PONPY		248
+16

Protein	Similar proteins		Species	Score	Length	Source
P11226	Mannose-binding protein C		TRAOB		248	UniRef50_P11226
Mannose-binding protein C		GORGO		248
Mannose-binding protein C		PONPY		248
Mannose-binding protein C		NOMCO		248
Mannose-binding protein C		HYLLA		248
+59

Cross-referencesⁱ

Web resourcesⁱ

Functional Glycomics Gateway - Glycan Binding

Mannose-binding protein

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X15422 mRNA Translation: CAA33462.1 X15954 , X15955, X15956, X15957 Genomic DNA Translation: CAA34079.1 AF080510, AF080508, AF080509 Genomic DNA Translation: AAC31937.1 Y16576 Genomic DNA Translation: CAB56044.1 Y16577 Genomic DNA Translation: CAB56120.1 Y16578 Genomic DNA Translation: CAB56045.1 Y16579 Genomic DNA Translation: CAB56121.1 Y16580 Genomic DNA Translation: CAB56122.1 Y16581 Genomic DNA Translation: CAB56123.1 Y16582 Genomic DNA Translation: CAB56124.1 AF360991 mRNA Translation: AAK52907.1 AY826184 mRNA Translation: AAV80468.1 DQ217939 Genomic DNA Translation: ABB01009.1 EU596574 Genomic DNA Translation: ACC62880.1 CH471083 Genomic DNA Translation: EAW54148.1 CH471083 Genomic DNA Translation: EAW54149.1 BC096179 mRNA Translation: AAH96179.1 BC096180 mRNA Translation: AAH96180.3 BC069338 mRNA Translation: AAH69338.1 BC096181 mRNA Translation: AAH96181.3 BC096182 mRNA Translation: AAH96182.3 AF482699 Genomic DNA Translation: AAN39274.1 AF482700 Genomic DNA Translation: AAN39275.1
CCDSⁱ	CCDS7247.1
PIRⁱ	JL0115 LNHUMC
RefSeqⁱ	NP_000233.1, NM_000242.2 XP_006717924.1, XM_006717861.3 XP_011538118.1, XM_011539816.2
UniGeneⁱ	Hs.499674

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1HUP	X-ray	2.50	A	108-248	[»]
ProteinModelPortalⁱ	P11226
SMRⁱ	P11226
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110323, 6 interactors
DIPⁱ	DIP-61381N
IntActⁱ	P11226, 6 interactors
MINTⁱ	P11226
STRINGⁱ	9606.ENSP00000363079

Chemistry databases

ChEMBLⁱ	CHEMBL1795113
DrugBankⁱ	DB03879 alpha-L-methyl-fucose DB04426 Alpha-Methyl-N-Acetyl-D-Glucosamine DB03194 beta-L-methyl-fucose DB01979 Methyl alpha-D-mannoside DB03721 N-acetyl-alpha-neuraminic acid DB01818 O3-Sulfonylgalactose DB02837 O4-Sulfonylgalactose

Protein family/group databases

UniLectinⁱ	P11226

UniLectinⁱ

P11226

PTM databases

iPTMnetⁱ	P11226
PhosphoSitePlusⁱ	P11226

Polymorphism and mutation databases

BioMutaⁱ	MBL2
DMDMⁱ	126676

Proteomic databases

PaxDbⁱ	P11226
PeptideAtlasⁱ	P11226
PRIDEⁱ	P11226
ProteomicsDBⁱ	52723
TopDownProteomicsⁱ	P11226

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	4153
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000373968; ENSP00000363079; ENSG00000165471
GeneIDⁱ	4153
KEGGⁱ	hsa:4153
UCSCⁱ	uc001jjt.3 human

Organism-specific databases

CTDⁱ	4153
DisGeNETⁱ	4153
EuPathDBⁱ	HostDB:ENSG00000165471.6
GeneCardsⁱ	MBL2
HGNCⁱ	HGNC:6922 MBL2
HPAⁱ	CAB016782 HPA002027
MalaCardsⁱ	MBL2
MIMⁱ	154545 gene 610424 phenotype 614372 phenotype
neXtProtⁱ	NX_P11226
OpenTargetsⁱ	ENSG00000165471
PharmGKBⁱ	PA30665
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IS38 Eukaryota ENOG410YQHR LUCA
GeneTreeⁱ	ENSGT00700000104102
HOVERGENⁱ	HBG108270
InParanoidⁱ	P11226
KOⁱ	K03991
OMAⁱ	YSETVTC
OrthoDBⁱ	EOG091G0R93
PhylomeDBⁱ	P11226
TreeFamⁱ	TF330481

Enzyme and pathway databases

Reactomeⁱ	R-HSA-166662 Lectin pathway of complement activation R-HSA-166663 Initial triggering of complement

Reactomeⁱ

R-HSA-166662 Lectin pathway of complement activation
R-HSA-166663 Initial triggering of complement

Miscellaneous databases

EvolutionaryTraceⁱ	P11226
GeneWikiⁱ	Mannan-binding_lectin
GenomeRNAiⁱ	4153
PMAP-CutDBⁱ	P11226
Protein Ontology More...PROⁱ	PR:P11226
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000165471 Expressed in 24 organ(s), highest expression level in liver
CleanExⁱ	HS_MBL2
Genevisibleⁱ	P11226 HS

Family and domain databases

CDDⁱ	cd03591 CLECT_collectin_like, 1 hit
Gene3Dⁱ	3.10.100.10, 1 hit
InterProⁱ	View protein in InterPro IPR001304 C-type_lectin-like IPR016186 C-type_lectin-like/link_sf IPR018378 C-type_lectin_CS IPR008160 Collagen IPR033990 Collectin_CTLD IPR016187 CTDL_fold IPR037570 Mannose-binding_protein
PANTHERⁱ	PTHR24020:SF0 PTHR24020:SF0, 1 hit
Pfamⁱ	View protein in Pfam PF01391 Collagen, 1 hit PF00059 Lectin_C, 1 hit
SMARTⁱ	View protein in SMART SM00034 CLECT, 1 hit
SUPFAMⁱ	SSF56436 SSF56436, 1 hit
PROSITEⁱ	View protein in PROSITE PS00615 C_TYPE_LECTIN_1, 1 hit PS50041 C_TYPE_LECTIN_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MBL2_HUMAN
Accessionⁱ	P11226Primary (citable) accession number: P11226 Secondary accession number(s): Q4VB12 Q96TF9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
	Last sequence update:	April 1, 1990
	Last modified:	September 12, 2018
	This is version 214 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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UniProtKB - P11226 (MBL2_HUMAN)

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Mannose-binding protein C

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ