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UniProtKB - P11226 (MBL2_HUMAN)

Entry version 235 (25 May 2022)
Sequence version 2 (01 Apr 1990)
Previous versions | rss
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Protein

Mannose-binding protein C

Gene

MBL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Calcium-dependent lectin involved in innate immune defense (PubMed:35102342).

Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA. Upon SARS coronavirus-2/SARS-CoV-2 infection, activates the complement lectin pathway which leads to the inhibition SARS-CoV-2 infection and a reduction of the induced inflammatory response (PubMed:35102342).

2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processComplement activation lectin pathway, Complement pathway, Immunity, Innate immunity
LigandCalcium, Lectin, Mannose-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P11226

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-166662, Lectin pathway of complement activation
R-HSA-166663, Initial triggering of complement

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P11226

SIGNOR Signaling Network Open Resource

More...SIGNORi		P11226

Protein family/group databases

UniLectin database of carbohydrate-binding proteins

More...UniLectini		P11226

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mannose-binding protein CCurated
Short name:
MBP-C
Alternative name(s):
Collectin-1
MBP1
Mannan-binding protein
Mannose-binding lectin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MBL2Imported
Synonyms:COLEC1, MBL
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6922, MBL2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		154545, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P11226

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000165471

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		4153

MalaCards human disease database

More...MalaCardsi		MBL2
MIMi610424, phenotype
614372, phenotype

Open Targets

More...OpenTargetsi		ENSG00000165471

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		449306, Dose selection of antibiotic therapy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30665

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P11226, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1795113

Drug and drug target database

More...DrugBanki		DB02837, 4-(Hydrogen sulfate)-beta-D-galactopyranose
DB03879, alpha-L-methyl-fucose
DB04426, Alpha-Methyl-N-Acetyl-D-Glucosamine
DB01979, Methyl alpha-D-mannoside
DB03194, Methyl beta-L-fucopyranoside
DB03721, N-acetyl-alpha-neuraminic acid
DB01818, O3-Sulfonylgalactose

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MBL2

Domain mapping of disease mutations (DMDM)

More...DMDMi		126676

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 201 PublicationAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001740121 – 248Mannose-binding protein CAdd BLAST228

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei47Hydroxyproline1 Publication1
Modified residuei73Hydroxyproline1 Publication1
Modified residuei79Hydroxyproline1 Publication1
Modified residuei82Hydroxyproline1 Publication1
Modified residuei88Hydroxyproline1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi155 ↔ 244
Disulfide bondi222 ↔ 236

Keywords - PTMi

Disulfide bond, Hydroxylation

Proteomic databases

The CPTAC Assay portal

More...CPTACi		non-CPTAC-2684

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P11226

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P11226

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P11226

PeptideAtlas

More...PeptideAtlasi		P11226

PRoteomics IDEntifications database

More...PRIDEi		P11226

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		52723

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P11226

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P11226

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P11226

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Plasma protein produced mainly in the liver.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000165471, Expressed in liver and 30 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P11226, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000165471, Tissue enriched (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Oligomeric complex of 3 or more homotrimers.

Interacts with MASP1 and MASP2.

Interacts with MEP1A and MEP1B and may inhibit their catalytic activity.

Interacts with CR1 (via Sushi 24 and Sushi 25 domains).

5 Publications

(Microbial infection) Interacts with SARS coronavirus-2/SARS-CoV-2 Spike glycoprotein homotrimer; the interaction is calcium-dependent and modulated by Spike glycoprotein glycosylation state.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110323, 33 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-6170, MBL2-MASP1 lectin-protease complex
CPX-6203, MBL2-MASP2 lectin-protease complex

Database of interacting proteins

More...DIPi		DIP-61381N

Protein interaction database and analysis system

More...IntActi		P11226, 26 interactors

Molecular INTeraction database

More...MINTi		P11226

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000363079

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P11226, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1248
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P11226

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P11226

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P11226

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini42 – 99Collagen-likeAdd BLAST58
Domaini134 – 245C-type lectinPROSITE-ProRule annotationAdd BLAST112

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni43 – 113DisorderedSequence analysisAdd BLAST71

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili112 – 1301 PublicationAdd BLAST19

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The coiled-coil domain mediates trimerization.

Keywords - Domaini

Coiled coil, Collagen, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4297, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154368

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_049894_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P11226

Identification of Orthologs from Complete Genome Data

More...OMAi		CAKFQAS

Database of Orthologous Groups

More...OrthoDBi		1222552at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P11226

TreeFam database of animal gene trees

More...TreeFami		TF330481

Family and domain databases

Conserved Domains Database

More...CDDi		cd03591, CLECT_collectin_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.10.100.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001304, C-type_lectin-like
IPR016186, C-type_lectin-like/link_sf
IPR018378, C-type_lectin_CS
IPR008160, Collagen
IPR033990, Collectin_CTLD
IPR016187, CTDL_fold
IPR037570, Mannose-binding_protein_C

The PANTHER Classification System

More...PANTHERi		PTHR24024:SF34, PTHR24024:SF34, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01391, Collagen, 1 hit
PF00059, Lectin_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00034, CLECT, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56436, SSF56436, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00615, C_TYPE_LECTIN_1, 1 hit
PS50041, C_TYPE_LECTIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P11226-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLFPSLPLL LLSMVAASYS ETVTCEDAQK TCPAVIACSS PGINGFPGKD 
        60         70         80         90        100
GRDGTKGEKG EPGQGLRGLQ GPPGKLGPPG NPGPSGSPGP KGQKGDPGKS 
       110        120        130        140        150
PDGDSSLAAS ERKALQTEMA RIKKWLTFSL GKQVGNKFFL TNGEIMTFEK 
       160        170        180        190        200
VKALCVKFQA SVATPRNAAE NGAIQNLIKE EAFLGITDEK TEGQFVDLTG 
       210        220        230        240 
NRLTYTNWNE GEPNNAGSDE DCVLLLKNGQ WNDVPCSTSH LAVCEFPI
Length:248
Mass (Da):26,144
Last modified:April 1, 1990 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC1F2AAED46D0F774
GO

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Genetic variations in MBL2 influence susceptibility to hepatitis B virus (HBV) infection [MIMi:610424].1 Publication
Genetic variations in MBL2 may influence susceptibility to severe COVID-19 disease caused by SARS-CoV-2 virus infection.1 Publication
Genetic variations in MBL2 are responsible for mannose-binding protein deficiency [MIMi:614372]. This condition is defined as MBL2 protein level of less than 100 ng/ml, is present in about 5% of people of European descent and in about 10% of sub-Saharan Africans. Most MBL2-deficient adults appear healthy, but low levels of MBL2 are associated with increased risk of infection in toddlers, in cancer patients undergoing chemotherapy, and in organ-transplant patients receiving immunosuppressive drugs, particularly recipients of liver transplants. There is an association between low levels of MBL2 and a defect of opsonization which results in susceptibility to frequent and chronic infections (PubMed:1675710). Functional MBL2 deficiency may be associated with protection against tuberculosis caused by Mycobacterium africanum but not by Mycobacterium tuberculosis, as observed in studies on Ghanaian patients with pulmonary tuberculosis (PubMed:21695215).2 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01329424T → A in Chinese. 1 Publication1
Natural variantiVAR_00854352R → C in 0.05% of European and African populations. 3 PublicationsCorresponds to variant dbSNP:rs5030737EnsemblClinVar.1
Natural variantiVAR_00418254G → D Associated with low serum mannose-binding protein (MBP) concentrations and recurrent infections. 8 PublicationsCorresponds to variant dbSNP:rs1800450EnsemblClinVar.1
Natural variantiVAR_00418357G → E Associated with low serum mannose-binding protein (MBP) concentrations; associated with protection against tuberculosis caused by Mycobacterium africanum. 5 PublicationsCorresponds to variant dbSNP:rs1800451EnsemblClinVar.1
Natural variantiVAR_050119214N → Y. Corresponds to variant dbSNP:rs12260094Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X15422 mRNA Translation: CAA33462.1
X15954 X15957 Genomic DNA Translation: CAA34079.1
AF080510, AF080508, AF080509 Genomic DNA Translation: AAC31937.1
Y16576 Genomic DNA Translation: CAB56044.1
Y16577 Genomic DNA Translation: CAB56120.1
Y16578 Genomic DNA Translation: CAB56045.1
Y16579 Genomic DNA Translation: CAB56121.1
Y16580 Genomic DNA Translation: CAB56122.1
Y16581 Genomic DNA Translation: CAB56123.1
Y16582 Genomic DNA Translation: CAB56124.1
AF360991 mRNA Translation: AAK52907.1
AY826184 mRNA Translation: AAV80468.1
DQ217939 Genomic DNA Translation: ABB01009.1
EU596574 Genomic DNA Translation: ACC62880.1
CH471083 Genomic DNA Translation: EAW54148.1
CH471083 Genomic DNA Translation: EAW54149.1
BC096179 mRNA Translation: AAH96179.1
BC096180 mRNA Translation: AAH96180.3
BC069338 mRNA Translation: AAH69338.1
BC096181 mRNA Translation: AAH96181.3
BC096182 mRNA Translation: AAH96182.3
AF482699 Genomic DNA Translation: AAN39274.1
AF482700 Genomic DNA Translation: AAN39275.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS7247.1

Protein sequence database of the Protein Information Resource

More...PIRi		JL0115, LNHUMC

NCBI Reference Sequences

More...RefSeqi		NP_000233.1, NM_000242.2
XP_006717924.1, XM_006717861.3
XP_011538118.1, XM_011539816.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000373968.3; ENSP00000363079.3; ENSG00000165471.7
ENST00000674931.1; ENSP00000502789.1; ENSG00000165471.7
ENST00000675947.1; ENSP00000502615.1; ENSG00000165471.7

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4153

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4153

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000674931.1; ENSP00000502789.1; NM_001378373.1; NP_001365302.1

UCSC genome browser

More...UCSCi		uc001jjt.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Mannose-binding protein

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15422 mRNA Translation: CAA33462.1
X15954 X15957 Genomic DNA Translation: CAA34079.1
AF080510, AF080508, AF080509 Genomic DNA Translation: AAC31937.1
Y16576 Genomic DNA Translation: CAB56044.1
Y16577 Genomic DNA Translation: CAB56120.1
Y16578 Genomic DNA Translation: CAB56045.1
Y16579 Genomic DNA Translation: CAB56121.1
Y16580 Genomic DNA Translation: CAB56122.1
Y16581 Genomic DNA Translation: CAB56123.1
Y16582 Genomic DNA Translation: CAB56124.1
AF360991 mRNA Translation: AAK52907.1
AY826184 mRNA Translation: AAV80468.1
DQ217939 Genomic DNA Translation: ABB01009.1
EU596574 Genomic DNA Translation: ACC62880.1
CH471083 Genomic DNA Translation: EAW54148.1
CH471083 Genomic DNA Translation: EAW54149.1
BC096179 mRNA Translation: AAH96179.1
BC096180 mRNA Translation: AAH96180.3
BC069338 mRNA Translation: AAH69338.1
BC096181 mRNA Translation: AAH96181.3
BC096182 mRNA Translation: AAH96182.3
AF482699 Genomic DNA Translation: AAN39274.1
AF482700 Genomic DNA Translation: AAN39275.1
CCDSiCCDS7247.1
PIRiJL0115, LNHUMC
RefSeqiNP_000233.1, NM_000242.2
XP_006717924.1, XM_006717861.3
XP_011538118.1, XM_011539816.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HUPX-ray2.50A108-248[»]
AlphaFoldDBiP11226
SMRiP11226
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi110323, 33 interactors
ComplexPortaliCPX-6170, MBL2-MASP1 lectin-protease complex
CPX-6203, MBL2-MASP2 lectin-protease complex
DIPiDIP-61381N
IntActiP11226, 26 interactors
MINTiP11226
STRINGi9606.ENSP00000363079

Chemistry databases

ChEMBLiCHEMBL1795113
DrugBankiDB02837, 4-(Hydrogen sulfate)-beta-D-galactopyranose
DB03879, alpha-L-methyl-fucose
DB04426, Alpha-Methyl-N-Acetyl-D-Glucosamine
DB01979, Methyl alpha-D-mannoside
DB03194, Methyl beta-L-fucopyranoside
DB03721, N-acetyl-alpha-neuraminic acid
DB01818, O3-Sulfonylgalactose

Protein family/group databases

UniLectiniP11226

PTM databases

iPTMnetiP11226
PhosphoSitePlusiP11226

Genetic variation databases

BioMutaiMBL2
DMDMi126676

Proteomic databases

CPTACinon-CPTAC-2684
jPOSTiP11226
MassIVEiP11226
PaxDbiP11226
PeptideAtlasiP11226
PRIDEiP11226
ProteomicsDBi52723
TopDownProteomicsiP11226

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		693, 746 antibodies from 40 providers

The DNASU plasmid repository

More...DNASUi		4153

Genome annotation databases

EnsembliENST00000373968.3; ENSP00000363079.3; ENSG00000165471.7
ENST00000674931.1; ENSP00000502789.1; ENSG00000165471.7
ENST00000675947.1; ENSP00000502615.1; ENSG00000165471.7
GeneIDi4153
KEGGihsa:4153
MANE-SelectiENST00000674931.1; ENSP00000502789.1; NM_001378373.1; NP_001365302.1
UCSCiuc001jjt.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4153
DisGeNETi4153

GeneCards: human genes, protein and diseases

More...GeneCardsi		MBL2
HGNCiHGNC:6922, MBL2
HPAiENSG00000165471, Tissue enriched (liver)
MalaCardsiMBL2
MIMi154545, gene
610424, phenotype
614372, phenotype
neXtProtiNX_P11226
OpenTargetsiENSG00000165471
Orphaneti449306, Dose selection of antibiotic therapy
PharmGKBiPA30665
VEuPathDBiHostDB:ENSG00000165471

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4297, Eukaryota
GeneTreeiENSGT00940000154368
HOGENOMiCLU_049894_3_0_1
InParanoidiP11226
OMAiCAKFQAS
OrthoDBi1222552at2759
PhylomeDBiP11226
TreeFamiTF330481

Enzyme and pathway databases

PathwayCommonsiP11226
ReactomeiR-HSA-166662, Lectin pathway of complement activation
R-HSA-166663, Initial triggering of complement
SignaLinkiP11226
SIGNORiP11226

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4153, 8 hits in 1070 CRISPR screens
EvolutionaryTraceiP11226

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Mannan-binding_lectin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4153
PharosiP11226, Tbio

Protein Ontology

More...PROi		PR:P11226
RNActiP11226, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000165471, Expressed in liver and 30 other tissues
GenevisibleiP11226, HS

Family and domain databases

CDDicd03591, CLECT_collectin_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304, C-type_lectin-like
IPR016186, C-type_lectin-like/link_sf
IPR018378, C-type_lectin_CS
IPR008160, Collagen
IPR033990, Collectin_CTLD
IPR016187, CTDL_fold
IPR037570, Mannose-binding_protein_C
PANTHERiPTHR24024:SF34, PTHR24024:SF34, 1 hit
PfamiView protein in Pfam
PF01391, Collagen, 1 hit
PF00059, Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034, CLECT, 1 hit
SUPFAMiSSF56436, SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615, C_TYPE_LECTIN_1, 1 hit
PS50041, C_TYPE_LECTIN_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMBL2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P11226
Secondary accession number(s): Q4VB12
, Q4VB13, Q4VB14, Q5SQS3, Q86SI4, Q96KE4, Q96TF7, Q96TF8, Q96TF9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: April 1, 1990
Last modified: May 25, 2022
This is version 235 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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