UniProtKB - P11226 (MBL2_HUMAN)
Protein
Mannose-binding protein C
Gene
MBL2
Organism
Homo sapiens (Human)
Status
Functioni
Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA.1 Publication
GO - Molecular functioni
- calcium-dependent protein binding Source: UniProtKB
- mannose binding Source: BHF-UCL
- signaling receptor binding Source: UniProtKB
GO - Biological processi
- acute-phase response Source: BHF-UCL
- complement activation Source: Reactome
- complement activation, classical pathway Source: UniProtKB-KW
- complement activation, lectin pathway Source: MGI
- defense response to bacterium Source: BHF-UCL
- defense response to Gram-positive bacterium Source: MGI
- innate immune response Source: BHF-UCL
- negative regulation of viral process Source: BHF-UCL
- opsonization Source: BHF-UCL
- response to oxidative stress Source: UniProtKB
Keywordsi
Biological process | Complement activation lectin pathway, Complement pathway, Immunity, Innate immunity |
Ligand | Calcium, Lectin, Mannose-binding |
Enzyme and pathway databases
PathwayCommonsi | P11226 |
Reactomei | R-HSA-166662, Lectin pathway of complement activation R-HSA-166663, Initial triggering of complement |
SIGNORi | P11226 |
Protein family/group databases
UniLectini | P11226 |
Names & Taxonomyi
Protein namesi | Recommended name: Mannose-binding protein CShort name: MBP-C Alternative name(s): Collectin-1 MBP1 Mannan-binding protein Mannose-binding lectin |
Gene namesi | Name:MBL2 Synonyms:COLEC1, MBL |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6922, MBL2 |
MIMi | 154545, gene |
neXtProti | NX_P11226 |
VEuPathDBi | HostDB:ENSG00000165471.6 |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: BHF-UCL
Other locations
- cell surface Source: BHF-UCL
- collagen trimer Source: UniProtKB-KW
- collagen-containing extracellular matrix Source: GO_Central
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 4153 |
MalaCardsi | MBL2 |
MIMi | 610424, phenotype 614372, phenotype |
OpenTargetsi | ENSG00000165471 |
Orphaneti | 449306, Susceptibility to infection in immunocompromised patient |
PharmGKBi | PA30665 |
Miscellaneous databases
Pharosi | P11226, Tbio |
Chemistry databases
ChEMBLi | CHEMBL1795113 |
DrugBanki | DB02837, 4-(Hydrogen sulfate)-beta-D-galactopyranose DB03879, alpha-L-methyl-fucose DB04426, Alpha-Methyl-N-Acetyl-D-Glucosamine DB01979, Methyl alpha-D-mannoside DB03194, Methyl beta-L-fucopyranoside DB03721, N-acetyl-alpha-neuraminic acid DB01818, O3-Sulfonylgalactose |
Genetic variation databases
BioMutai | MBL2 |
DMDMi | 126676 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | 1 PublicationAdd BLAST | 20 | |
ChainiPRO_0000017401 | 21 – 248 | Mannose-binding protein CAdd BLAST | 228 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 47 | Hydroxyproline1 Publication | 1 | |
Modified residuei | 73 | Hydroxyproline1 Publication | 1 | |
Modified residuei | 79 | Hydroxyproline1 Publication | 1 | |
Modified residuei | 82 | Hydroxyproline1 Publication | 1 | |
Modified residuei | 88 | Hydroxyproline1 Publication | 1 | |
Disulfide bondi | 155 ↔ 244 | |||
Disulfide bondi | 222 ↔ 236 |
Keywords - PTMi
Disulfide bond, HydroxylationProteomic databases
CPTACi | non-CPTAC-2684 |
jPOSTi | P11226 |
MassIVEi | P11226 |
PaxDbi | P11226 |
PeptideAtlasi | P11226 |
PRIDEi | P11226 |
ProteomicsDBi | 52723 |
TopDownProteomicsi | P11226 |
PTM databases
iPTMneti | P11226 |
PhosphoSitePlusi | P11226 |
Expressioni
Tissue specificityi
Plasma protein produced mainly in the liver.1 Publication
Gene expression databases
Bgeei | ENSG00000165471, Expressed in liver and 30 other tissues |
Genevisiblei | P11226, HS |
Organism-specific databases
HPAi | ENSG00000165471, Tissue enriched (liver) |
Interactioni
Subunit structurei
Oligomeric complex of 3 or more homotrimers.
Interacts with MASP1 and MASP2.
Interacts with MEP1A and MEP1B and may inhibit their catalytic activity.
Interacts with CR1 (via Sushi 24 and Sushi 25 domains).
5 PublicationsBinary interactionsi
Hide detailsP11226
GO - Molecular functioni
- calcium-dependent protein binding Source: UniProtKB
- signaling receptor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 110323, 8 interactors |
ComplexPortali | CPX-6170, MBL2-MASP1 lectin-protease complex CPX-6203, MBL2-MASP2 lectin-protease complex |
DIPi | DIP-61381N |
IntActi | P11226, 10 interactors |
MINTi | P11226 |
STRINGi | 9606.ENSP00000363079 |
Miscellaneous databases
RNActi | P11226, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P11226 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P11226 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 42 – 99 | Collagen-likeAdd BLAST | 58 | |
Domaini | 134 – 245 | C-type lectinPROSITE-ProRule annotationAdd BLAST | 112 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 112 – 130 | 1 PublicationAdd BLAST | 19 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 21 – 41 | Cys-richAdd BLAST | 21 |
Domaini
The coiled-coil domain mediates trimerization.
Keywords - Domaini
Coiled coil, Collagen, Repeat, SignalPhylogenomic databases
eggNOGi | KOG4297, Eukaryota |
GeneTreei | ENSGT00940000154368 |
HOGENOMi | CLU_049894_3_0_1 |
InParanoidi | P11226 |
OMAi | KTCPAVI |
OrthoDBi | 1222552at2759 |
PhylomeDBi | P11226 |
TreeFami | TF330481 |
Family and domain databases
CDDi | cd03591, CLECT_collectin_like, 1 hit |
Gene3Di | 3.10.100.10, 1 hit |
InterProi | View protein in InterPro IPR001304, C-type_lectin-like IPR016186, C-type_lectin-like/link_sf IPR018378, C-type_lectin_CS IPR008160, Collagen IPR033990, Collectin_CTLD IPR016187, CTDL_fold IPR037570, Mannose-binding_protein_C |
PANTHERi | PTHR24024:SF34, PTHR24024:SF34, 1 hit |
Pfami | View protein in Pfam PF01391, Collagen, 1 hit PF00059, Lectin_C, 1 hit |
SMARTi | View protein in SMART SM00034, CLECT, 1 hit |
SUPFAMi | SSF56436, SSF56436, 1 hit |
PROSITEi | View protein in PROSITE PS00615, C_TYPE_LECTIN_1, 1 hit PS50041, C_TYPE_LECTIN_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P11226-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLFPSLPLL LLSMVAASYS ETVTCEDAQK TCPAVIACSS PGINGFPGKD
60 70 80 90 100
GRDGTKGEKG EPGQGLRGLQ GPPGKLGPPG NPGPSGSPGP KGQKGDPGKS
110 120 130 140 150
PDGDSSLAAS ERKALQTEMA RIKKWLTFSL GKQVGNKFFL TNGEIMTFEK
160 170 180 190 200
VKALCVKFQA SVATPRNAAE NGAIQNLIKE EAFLGITDEK TEGQFVDLTG
210 220 230 240
NRLTYTNWNE GEPNNAGSDE DCVLLLKNGQ WNDVPCSTSH LAVCEFPI
Polymorphismi
Genetic variations in MBL2 influence susceptibility to hepatitis B virus (HBV) infection [MIMi:610424].
Genetic variations in MBL2 are responsible for mannose-binding protein deficiency [MIMi:614372]. This condition is defined as MBL2 protein level of less than 100 ng/ml, is present in about 5% of people of European descent and in about 10% of sub-Saharan Africans. Most MBL2-deficient adults appear healthy, but low levels of MBL2 are associated with increased risk of infection in toddlers, in cancer patients undergoing chemotherapy, and in organ-transplant patients receiving immunosuppressive drugs, particularly recipients of liver transplants. There is an association between low levels of MBL2 and a defect of opsonization which results in susceptibility to frequent and chronic infections (PubMed:1675710). Functional MBL2 deficiency may be associated with protection against tuberculosis caused by Mycobacterium africanum but not by Mycobacterium tuberculosis, as observed in studies on Ghanaian patients with pulmonary tuberculosis (PubMed:21695215).2 Publications
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_013294 | 24 | T → A in Chinese. 1 Publication | 1 | |
Natural variantiVAR_008543 | 52 | R → C in 0.05% of European and African populations. 3 PublicationsCorresponds to variant dbSNP:rs5030737EnsemblClinVar. | 1 | |
Natural variantiVAR_004182 | 54 | G → D Associated with low serum mannose-binding protein (MBP) concentrations and recurrent infections. 8 PublicationsCorresponds to variant dbSNP:rs1800450EnsemblClinVar. | 1 | |
Natural variantiVAR_004183 | 57 | G → E Associated with low serum mannose-binding protein (MBP) concentrations; associated with protection against tuberculosis caused by Mycobacterium africanum. 5 PublicationsCorresponds to variant dbSNP:rs1800451EnsemblClinVar. | 1 | |
Natural variantiVAR_050119 | 214 | N → Y. Corresponds to variant dbSNP:rs12260094Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X15422 mRNA Translation: CAA33462.1 X15954 , X15955, X15956, X15957 Genomic DNA Translation: CAA34079.1 AF080510, AF080508, AF080509 Genomic DNA Translation: AAC31937.1 Y16576 Genomic DNA Translation: CAB56044.1 Y16577 Genomic DNA Translation: CAB56120.1 Y16578 Genomic DNA Translation: CAB56045.1 Y16579 Genomic DNA Translation: CAB56121.1 Y16580 Genomic DNA Translation: CAB56122.1 Y16581 Genomic DNA Translation: CAB56123.1 Y16582 Genomic DNA Translation: CAB56124.1 AF360991 mRNA Translation: AAK52907.1 AY826184 mRNA Translation: AAV80468.1 DQ217939 Genomic DNA Translation: ABB01009.1 EU596574 Genomic DNA Translation: ACC62880.1 CH471083 Genomic DNA Translation: EAW54148.1 CH471083 Genomic DNA Translation: EAW54149.1 BC096179 mRNA Translation: AAH96179.1 BC096180 mRNA Translation: AAH96180.3 BC069338 mRNA Translation: AAH69338.1 BC096181 mRNA Translation: AAH96181.3 BC096182 mRNA Translation: AAH96182.3 AF482699 Genomic DNA Translation: AAN39274.1 AF482700 Genomic DNA Translation: AAN39275.1 |
CCDSi | CCDS7247.1 |
PIRi | JL0115, LNHUMC |
RefSeqi | NP_000233.1, NM_000242.2 XP_006717924.1, XM_006717861.3 XP_011538118.1, XM_011539816.2 |
Genome annotation databases
Ensembli | ENST00000373968; ENSP00000363079; ENSG00000165471 ENST00000674931; ENSP00000502789; ENSG00000165471 ENST00000675947; ENSP00000502615; ENSG00000165471 |
GeneIDi | 4153 |
KEGGi | hsa:4153 |
UCSCi | uc001jjt.3, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Functional Glycomics Gateway - Glycan Binding Mannose-binding protein |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X15422 mRNA Translation: CAA33462.1 X15954 , X15955, X15956, X15957 Genomic DNA Translation: CAA34079.1 AF080510, AF080508, AF080509 Genomic DNA Translation: AAC31937.1 Y16576 Genomic DNA Translation: CAB56044.1 Y16577 Genomic DNA Translation: CAB56120.1 Y16578 Genomic DNA Translation: CAB56045.1 Y16579 Genomic DNA Translation: CAB56121.1 Y16580 Genomic DNA Translation: CAB56122.1 Y16581 Genomic DNA Translation: CAB56123.1 Y16582 Genomic DNA Translation: CAB56124.1 AF360991 mRNA Translation: AAK52907.1 AY826184 mRNA Translation: AAV80468.1 DQ217939 Genomic DNA Translation: ABB01009.1 EU596574 Genomic DNA Translation: ACC62880.1 CH471083 Genomic DNA Translation: EAW54148.1 CH471083 Genomic DNA Translation: EAW54149.1 BC096179 mRNA Translation: AAH96179.1 BC096180 mRNA Translation: AAH96180.3 BC069338 mRNA Translation: AAH69338.1 BC096181 mRNA Translation: AAH96181.3 BC096182 mRNA Translation: AAH96182.3 AF482699 Genomic DNA Translation: AAN39274.1 AF482700 Genomic DNA Translation: AAN39275.1 |
CCDSi | CCDS7247.1 |
PIRi | JL0115, LNHUMC |
RefSeqi | NP_000233.1, NM_000242.2 XP_006717924.1, XM_006717861.3 XP_011538118.1, XM_011539816.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1HUP | X-ray | 2.50 | A | 108-248 | [»] | |
SMRi | P11226 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110323, 8 interactors |
ComplexPortali | CPX-6170, MBL2-MASP1 lectin-protease complex CPX-6203, MBL2-MASP2 lectin-protease complex |
DIPi | DIP-61381N |
IntActi | P11226, 10 interactors |
MINTi | P11226 |
STRINGi | 9606.ENSP00000363079 |
Chemistry databases
ChEMBLi | CHEMBL1795113 |
DrugBanki | DB02837, 4-(Hydrogen sulfate)-beta-D-galactopyranose DB03879, alpha-L-methyl-fucose DB04426, Alpha-Methyl-N-Acetyl-D-Glucosamine DB01979, Methyl alpha-D-mannoside DB03194, Methyl beta-L-fucopyranoside DB03721, N-acetyl-alpha-neuraminic acid DB01818, O3-Sulfonylgalactose |
Protein family/group databases
UniLectini | P11226 |
PTM databases
iPTMneti | P11226 |
PhosphoSitePlusi | P11226 |
Genetic variation databases
BioMutai | MBL2 |
DMDMi | 126676 |
Proteomic databases
CPTACi | non-CPTAC-2684 |
jPOSTi | P11226 |
MassIVEi | P11226 |
PaxDbi | P11226 |
PeptideAtlasi | P11226 |
PRIDEi | P11226 |
ProteomicsDBi | 52723 |
TopDownProteomicsi | P11226 |
Protocols and materials databases
Antibodypediai | 693, 742 antibodies |
DNASUi | 4153 |
Genome annotation databases
Ensembli | ENST00000373968; ENSP00000363079; ENSG00000165471 ENST00000674931; ENSP00000502789; ENSG00000165471 ENST00000675947; ENSP00000502615; ENSG00000165471 |
GeneIDi | 4153 |
KEGGi | hsa:4153 |
UCSCi | uc001jjt.3, human |
Organism-specific databases
CTDi | 4153 |
DisGeNETi | 4153 |
GeneCardsi | MBL2 |
HGNCi | HGNC:6922, MBL2 |
HPAi | ENSG00000165471, Tissue enriched (liver) |
MalaCardsi | MBL2 |
MIMi | 154545, gene 610424, phenotype 614372, phenotype |
neXtProti | NX_P11226 |
OpenTargetsi | ENSG00000165471 |
Orphaneti | 449306, Susceptibility to infection in immunocompromised patient |
PharmGKBi | PA30665 |
VEuPathDBi | HostDB:ENSG00000165471.6 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4297, Eukaryota |
GeneTreei | ENSGT00940000154368 |
HOGENOMi | CLU_049894_3_0_1 |
InParanoidi | P11226 |
OMAi | KTCPAVI |
OrthoDBi | 1222552at2759 |
PhylomeDBi | P11226 |
TreeFami | TF330481 |
Enzyme and pathway databases
PathwayCommonsi | P11226 |
Reactomei | R-HSA-166662, Lectin pathway of complement activation R-HSA-166663, Initial triggering of complement |
SIGNORi | P11226 |
Miscellaneous databases
BioGRID-ORCSi | 4153, 4 hits in 986 CRISPR screens |
EvolutionaryTracei | P11226 |
GeneWikii | Mannan-binding_lectin |
GenomeRNAii | 4153 |
Pharosi | P11226, Tbio |
PROi | PR:P11226 |
RNActi | P11226, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000165471, Expressed in liver and 30 other tissues |
Genevisiblei | P11226, HS |
Family and domain databases
CDDi | cd03591, CLECT_collectin_like, 1 hit |
Gene3Di | 3.10.100.10, 1 hit |
InterProi | View protein in InterPro IPR001304, C-type_lectin-like IPR016186, C-type_lectin-like/link_sf IPR018378, C-type_lectin_CS IPR008160, Collagen IPR033990, Collectin_CTLD IPR016187, CTDL_fold IPR037570, Mannose-binding_protein_C |
PANTHERi | PTHR24024:SF34, PTHR24024:SF34, 1 hit |
Pfami | View protein in Pfam PF01391, Collagen, 1 hit PF00059, Lectin_C, 1 hit |
SMARTi | View protein in SMART SM00034, CLECT, 1 hit |
SUPFAMi | SSF56436, SSF56436, 1 hit |
PROSITEi | View protein in PROSITE PS00615, C_TYPE_LECTIN_1, 1 hit PS50041, C_TYPE_LECTIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MBL2_HUMAN | |
Accessioni | P11226Primary (citable) accession number: P11226 Secondary accession number(s): Q4VB12 Q96TF9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | April 1, 1990 | |
Last modified: | April 7, 2021 | |
This is version 231 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references