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Protein

Spike glycoprotein

Gene

S

Organism
Avian infectious bronchitis virus (strain Beaudette) (IBV)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Spike protein S1: attaches the virion to the host cell membrane by interacting with sialic acids, initiating the infection.UniRule annotation2 Publications
Spike protein S2: mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.UniRule annotation
Spike protein S2': Acts as a viral fusion peptide after S2 cleavage occurring upon virus endocytosis.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processFusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Virulence, Virus endocytosis by host, Virus entry into host cell

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Spike glycoproteinUniRule annotation
Short name:
S glycoproteinUniRule annotation
Alternative name(s):
E2UniRule annotation
Peplomer proteinUniRule annotation
Cleaved into the following 3 chains:
Spike protein S1UniRule annotation
Spike protein S2UniRule annotation
Spike protein S2'UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SUniRule annotation
ORF Names:2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAvian infectious bronchitis virus (strain Beaudette) (IBV)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri11122 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageNidoviralesCoronaviridaeCoronavirinaeGammacoronavirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiGallus gallus (Chicken) [TaxID: 9031]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006717 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Spike protein S2 :
Spike protein S1 :

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini19 – 1095ExtracellularUniRule annotationAdd BLAST1077
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1096 – 1116HelicalUniRule annotationAdd BLAST21
Topological domaini1117 – 1162CytoplasmicUniRule annotationAdd BLAST46

GO - Cellular componenti

Keywords - Cellular componenti

Host membrane, Membrane, Viral envelope protein, Virion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1159K → A: Localizes exclusively to the cell membrane. 1 Publication1
Mutagenesisi1160K → A: Localizes exclusively to the cell membrane. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18UniRule annotationAdd BLAST18
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003716219 – 1162Spike glycoproteinUniRule annotationAdd BLAST1144
ChainiPRO_000003716319 – 537Spike protein S1UniRule annotation1 PublicationAdd BLAST519
ChainiPRO_0000037164538 – 1162Spike protein S2UniRule annotation1 PublicationAdd BLAST625
ChainiPRO_0000444092691 – 1162Spike protein S2'UniRule annotation1 PublicationAdd BLAST472

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi51N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi77N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi103N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi144N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi163N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi178N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi212N-linked (GlcNAc...) asparagine; by hostUniRule annotation1 Publication1
Glycosylationi237N-linked (GlcNAc...) asparagine; by hostUniRule annotation1 Publication1
Glycosylationi247N-linked (GlcNAc...) asparagine; by hostUniRule annotation1 Publication1
Glycosylationi264N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi276N-linked (GlcNAc...) asparagine; by hostUniRule annotation1 Publication1
Glycosylationi306N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi425N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi447N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi513N-linked (GlcNAc...) asparagine; by hostUniRule annotation1 Publication1
Glycosylationi530N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi579N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi591N-linked (GlcNAc...) asparagine; by hostUniRule annotation1 Publication1
Glycosylationi669N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi676N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi714N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi947N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi960N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi979N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi1014N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi1038N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi1051N-linked (GlcNAc...) asparagine; by hostUniRule annotation1 Publication1
Glycosylationi1074N-linked (GlcNAc...) asparagine; by hostUniRule annotation1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins. The precursor is processed into S1 and S2 by host cell furin or furin-like protease to yield the mature S1 and S2 proteins. The cleavage site between S1 and S2 requires the optimal sequence [KR]-X-[KR]-R. Additionally, a second cleavage leads to the release of a fusion peptide after viral attachment to host cell receptor.UniRule annotation1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei537 – 538Cleavage; by host furinUniRule annotation1 Publication2
Sitei690 – 691Cleavage; by host furinUniRule annotation1 Publication2

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P11223

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer; each monomer consists of a S1 and a S2 subunit. The resulting peplomers protrude from the virus surface as spikes.UniRule annotation

Protein-protein interaction databases

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
P11223

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P11223

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P11223

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili822 – 866UniRule annotationAdd BLAST45
Coiled coili1055 – 1083UniRule annotationAdd BLAST29

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1159 – 1162Di-lysine motifUniRule annotation4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1120 – 1137Cys-richAdd BLAST18

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.UniRule annotation

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the gammacoronaviruses spike protein family.UniRule annotation

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K19254

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.5.790, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_04098 GAMMA_CORONA_SPIKE, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002551 Corona_S1
IPR002552 Corona_S2
IPR027400 S_HR2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01600 Corona_S1, 1 hit
PF01601 Corona_S2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P11223-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLVTPLLLVT LLCALCSAVL YDSSSYVYYY QSAFRPPSGW HLQGGAYAVV
60 70 80 90 100
NISSEFNNAG SSSGCTVGII HGGRVVNASS IAMTAPSSGM AWSSSQFCTA
110 120 130 140 150
HCNFSDTTVF VTHCYKHGGC PLTGMLQQNL IRVSAMKNGQ LFYNLTVSVA
160 170 180 190 200
KYPTFRSFQC VNNLTSVYLN GDLVYTSNET IDVTSAGVYF KAGGPITYKV
210 220 230 240 250
MREVKALAYF VNGTAQDVIL CDGSPRGLLA CQYNTGNFSD GFYPFTNSSL
260 270 280 290 300
VKQKFIVYRE NSVNTTCTLH NFIFHNETGA NPNPSGVQNI QTYQTKTAQS
310 320 330 340 350
GYYNFNFSFL SSFVYKESNF MYGSYHPSCK FRLETINNGL WFNSLSVSIA
360 370 380 390 400
YGPLQGGCKQ SVFKGRATCC YAYSYGGPSL CKGVYSGELD HNFECGLLVY
410 420 430 440 450
VTKSGGSRIQ TATEPPVITQ NNYNNITLNT CVDYNIYGRT GQGFITNVTD
460 470 480 490 500
SAVSYNYLAD AGLAILDTSG SIDIFVVQGE YGLNYYKVNP CEDVNQQFVV
510 520 530 540 550
SGGKLVGILT SRNETGSQLL ENQFYIKITN GTRRFRRSIT ENVANCPYVS
560 570 580 590 600
YGKFCIKPDG SIATIVPKQL EQFVAPLFNV TENVLIPNSF NLTVTDEYIQ
610 620 630 640 650
TRMDKVQINC LQYVCGSSLD CRKLFQQYGP VCDNILSVVN SVGQKEDMEL
660 670 680 690 700
LNFYSSTKPA GFNTPVLSNV STGEFNISLL LTNPSSRRKR SLIEDLLFTS
710 720 730 740 750
VESVGLPTND AYKNCTAGPL GFFKDLACAR EYNGLLVLPP IITAEMQALY
760 770 780 790 800
TSSLVASMAF GGITAAGAIP FATQLQARIN HLGITQSLLL KNQEKIAASF
810 820 830 840 850
NKAIGHMQEG FRSTSLALQQ IQDVVSKQSA ILTETMASLN KNFGAISSVI
860 870 880 890 900
QEIYQQFDAI QANAQVDRLI TGRLSSLSVL ASAKQAEYIR VSQQRELATQ
910 920 930 940 950
KINECVKSQS IRYSFCGNGR HVLTIPQNAP NGIVFIHFSY TPDSFVNVTA
960 970 980 990 1000
IVGFCVKPAN ASQYAIVPAN GRGIFIQVNG SYYITARDMY MPRAITAGDV
1010 1020 1030 1040 1050
VTLTSCQANY VSVNKTVITT FVDNDDFDFN DELSKWWNDT KHELPDFDKF
1060 1070 1080 1090 1100
NYTVPILDID SEIDRIQGVI QGLNDSLIDL EKLSILKTYI KWPWYVWLAI
1110 1120 1130 1140 1150
AFATIIFILI LGWVFFMTGC CGCCCGCFGI MPLMSKCGKK SSYYTTFDND
1160
VVTEQYRPKK SV
Length:1,162
Mass (Da):128,047
Last modified:July 1, 1989 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0BAAD58113C8EBD5
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti122L → I in strain: Isolate Vero cell-adapted p36 and Isolate Vero cell-adapted p65. 1
Natural varianti130L → F in strain: Isolate Vero cell-adapted p36 and Isolate Vero cell-adapted p65. 1
Natural varianti364K → R in strain: Isolate Vero cell-adapted p36 and Isolate Vero cell-adapted p65. 1
Natural varianti405G → D in strain: Isolate Vero cell-adapted p36 and Isolate Vero cell-adapted p65. 1
Natural varianti421N → H in strain: Isolate Vero cell-adapted p36 and Isolate Vero cell-adapted p65. 1
Natural varianti623K → N in strain: Isolate Vero cell-adapted p36 and Isolate Vero cell-adapted p65. 1
Natural varianti683N → T in strain: Isolate Vero cell-adapted p36 and Isolate Vero cell-adapted p65. 1
Natural varianti689K → R in strain: Isolate Vero cell-adapted p36 and Isolate Vero cell-adapted p65. 1
Natural varianti692L → V in strain: Isolate Vero cell-adapted p36 and Isolate Vero cell-adapted p65. 1
Natural varianti709N → D in strain: Isolate Vero cell-adapted p36 and Isolate Vero cell-adapted p65. 1
Natural varianti723F → L in strain: Isolate Vero cell-adapted p36 and Isolate Vero cell-adapted p65. 1
Natural varianti1012S → I in strain: Isolate Vero cell-adapted p36 and Isolate Vero cell-adapted p65. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M95169 Genomic RNA Translation: AAA70235.1
X02342 Genomic RNA Translation: CAA26201.1
DQ001342 mRNA Translation: AAY21248.1
DQ001339 Genomic RNA Translation: AAY24433.1

Protein sequence database of the Protein Information Resource

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PIRi
S14939

NCBI Reference Sequences

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RefSeqi
NP_040831.1, NC_001451.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
1489741

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vg:1489741

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95169 Genomic RNA Translation: AAA70235.1
X02342 Genomic RNA Translation: CAA26201.1
DQ001342 mRNA Translation: AAY21248.1
DQ001339 Genomic RNA Translation: AAY24433.1
PIRiS14939
RefSeqiNP_040831.1, NC_001451.1

3D structure databases

ProteinModelPortaliP11223
SMRiP11223
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ELMiP11223

Proteomic databases

PRIDEiP11223

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1489741
KEGGivg:1489741

Phylogenomic databases

KOiK19254

Family and domain databases

Gene3Di1.20.5.790, 1 hit
HAMAPiMF_04098 GAMMA_CORONA_SPIKE, 1 hit
InterProiView protein in InterPro
IPR002551 Corona_S1
IPR002552 Corona_S2
IPR027400 S_HR2
PfamiView protein in Pfam
PF01600 Corona_S1, 1 hit
PF01601 Corona_S2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPIKE_IBVB
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P11223
Secondary accession number(s): P05134, Q4ZJS1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: January 16, 2019
This is version 109 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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