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Protein

Chitinase 63

Gene

chtA

Organism
Streptomyces plicatus
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei383Proton donorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Chitin degradation, Polysaccharide degradation
LigandChitin-binding

Protein family/group databases

CAZyiCBM2 Carbohydrate-Binding Module Family 2
GH18 Glycoside Hydrolase Family 18

Names & Taxonomyi

Protein namesi
Recommended name:
Chitinase 63 (EC:3.2.1.14)
Gene namesi
Name:chtA
OrganismiStreptomyces plicatus
Taxonomic identifieri1922 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 301 PublicationAdd BLAST30
ChainiPRO_000001191231 – 610Chitinase 63Add BLAST580

Proteomic databases

PRIDEiP11220

Expressioni

Inductioni

By chitin.

Structurei

3D structure databases

ProteinModelPortaliP11220
SMRiP11220
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 134CBM2PROSITE-ProRule annotationAdd BLAST104
Domaini144 – 229Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni236 – 610CatalyticAdd BLAST375

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 1 hit
2.60.40.290, 1 hit
3.10.50.10, 1 hit
InterProiView protein in InterPro
IPR001919 CBD2
IPR008965 CBM2/CBM3_carb-bd_dom_sf
IPR012291 CBM2_carb-bd_dom_sf
IPR018366 CBM2_CS
IPR011583 Chitinase_II
IPR029070 Chitinase_insertion_sf
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR001223 Glyco_hydro18_cat
IPR001579 Glyco_hydro_18_chit_AS
IPR017853 Glycoside_hydrolase_SF
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF00553 CBM_2, 1 hit
PF00041 fn3, 1 hit
PF00704 Glyco_hydro_18, 1 hit
SMARTiView protein in SMART
SM00637 CBD_II, 1 hit
SM00060 FN3, 1 hit
SM00636 Glyco_18, 1 hit
SUPFAMiSSF49265 SSF49265, 1 hit
SSF49384 SSF49384, 1 hit
SSF51445 SSF51445, 2 hits
SSF54556 SSF54556, 1 hit
PROSITEiView protein in PROSITE
PS51173 CBM2, 1 hit
PS00561 CBM2_A, 1 hit
PS01095 CHITINASE_18, 1 hit
PS00018 EF_HAND_1, 1 hit
PS50853 FN3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11220-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFRHKAAAL AATLALPLAG LVGLASPAQA ATSATATFQK TSDWGTGFGG
60 70 80 90 100
KWTVKNTGTT SLSSWTVEWD FPSGTKVTSA WDATVTNSAD HWTAKNVGWN
110 120 130 140 150
GTLAPGASVS FGFNGSGPGS PSGCKINGGS CDGSSVPGDE APSAPGTPTA
160 170 180 190 200
SNITDTSVKL SWSAATDDKG VKNYDVLRDG ATVATVTGTT YTDNGLTKGT
210 220 230 240 250
DYSYSVKARD TGDQTGPASG SVKVTTTGGD GGEPNPNPGA EVKMGYFTNW
260 270 280 290 300
GVYGRNYHVK NLVTSGSAEK ITHINLRFGN VQGGKCTIGD AYADYDKAYT
310 320 330 340 350
ADQSVDGVAD TWDQPLRANF NQLRNLKAEY PHIKILYSFG GWTWSGGFPD
360 370 380 390 400
AVKNPAAFAK SCHDLVEDPR WADVFDGIDL DWEYPNACGL SCDETSAPNA
410 420 430 440 450
FSSMMKAMRA EFGQDYLITA AVTADGSDGG KIDAADYGEA SKYIDWYNVM
460 470 480 490 500
TYDFFGAWAK NGPTAPHSPL NAYDGIPQQG FTTADAMAKF KSKGVPADKL
510 520 530 540 550
LIGIGFYGRG WTGVTQSAPG GTATGPAAGT YEAGIEDYKV LKNSCPATGT
560 570 580 590 600
VAGTAYAHCG TNWWSYDTPA TIKSKMDWAE QQGLGGAFFW EFSGDTTNGE
610
LVSAIDSGLK
Length:610
Mass (Da):63,974
Last modified:December 1, 1992 - v2
Checksum:i6A202EF361CCD500
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3F → I in AAA26717 (PubMed:3275646).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M82804 Genomic DNA Translation: AAA26720.1
M18397 Genomic DNA Translation: AAA26717.1
PIRiJH0573

Similar proteinsi

Entry informationi

Entry nameiCHIT_STRPL
AccessioniPrimary (citable) accession number: P11220
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: December 1, 1992
Last modified: April 25, 2018
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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