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UniProtKB - P11220 (CHIT_STRPL)
Protein
Chitinase 63
Gene
chtA
Organism
Streptomyces plicatus
Status
Functioni
Catalytic activityi
- Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins. EC:3.2.1.14
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 383 | Proton donorPROSITE-ProRule annotation | 1 | |
Binding sitei | 384 | ChitooligosaccharidePROSITE-ProRule annotation | 1 | |
Binding sitei | 590 | ChitooligosaccharidePROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- chitinase activity Source: UniProtKB-EC
- chitin binding Source: UniProtKB-KW
- polysaccharide binding Source: InterPro
GO - Biological processi
- chitin catabolic process Source: UniProtKB-KW
- polysaccharide catabolic process Source: UniProtKB-KW
Keywordsi
Molecular function | Glycosidase, Hydrolase |
Biological process | Carbohydrate metabolism, Chitin degradation, Polysaccharide degradation |
Ligand | Chitin-binding |
Protein family/group databases
CAZyi | CBM2, Carbohydrate-Binding Module Family 2 GH18, Glycoside Hydrolase Family 18 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:chtA |
Organismi | Streptomyces plicatus |
Taxonomic identifieri | 1922 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Streptomycetales › Streptomycetaceae › Streptomyces › Streptomyces rochei group |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 30 | 1 PublicationAdd BLAST | 30 | |
ChainiPRO_0000011912 | 31 – 610 | Chitinase 63Add BLAST | 580 |
Proteomic databases
PRIDEi | P11220 |
Expressioni
Inductioni
By chitin.
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 31 – 134 | CBM2PROSITE-ProRule annotationAdd BLAST | 104 | |
Domaini | 144 – 229 | Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST | 86 | |
Domaini | 241 – 610 | GH18PROSITE-ProRule annotationAdd BLAST | 370 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 125 – 153 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 208 – 239 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 313 – 314 | Chitooligosaccharide bindingPROSITE-ProRule annotation | 2 | |
Regioni | 340 – 343 | Chitooligosaccharide bindingPROSITE-ProRule annotation | 4 | |
Regioni | 450 – 453 | Chitooligosaccharide bindingPROSITE-ProRule annotation | 4 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 208 – 232 | Polar residuesSequence analysisAdd BLAST | 25 |
Sequence similaritiesi
Keywords - Domaini
SignalFamily and domain databases
CDDi | cd00063, FN3, 1 hit |
Gene3Di | 2.60.40.10, 1 hit 2.60.40.290, 1 hit 3.10.50.10, 1 hit |
InterProi | View protein in InterPro IPR001919, CBD2 IPR008965, CBM2/CBM3_carb-bd_dom_sf IPR012291, CBM2_carb-bd_dom_sf IPR018366, CBM2_CS IPR011583, Chitinase_II IPR029070, Chitinase_insertion_sf IPR003961, FN3_dom IPR036116, FN3_sf IPR001223, Glyco_hydro18_cat IPR001579, Glyco_hydro_18_chit_AS IPR017853, Glycoside_hydrolase_SF IPR013783, Ig-like_fold |
Pfami | View protein in Pfam PF00553, CBM_2, 1 hit PF00041, fn3, 1 hit PF00704, Glyco_hydro_18, 1 hit |
SMARTi | View protein in SMART SM00637, CBD_II, 1 hit SM00060, FN3, 1 hit SM00636, Glyco_18, 1 hit |
SUPFAMi | SSF49265, SSF49265, 1 hit SSF49384, SSF49384, 1 hit SSF51445, SSF51445, 1 hit SSF54556, SSF54556, 1 hit |
PROSITEi | View protein in PROSITE PS51173, CBM2, 1 hit PS00561, CBM2_A, 1 hit PS00018, EF_HAND_1, 1 hit PS50853, FN3, 1 hit PS01095, GH18_1, 1 hit PS51910, GH18_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P11220-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRFRHKAAAL AATLALPLAG LVGLASPAQA ATSATATFQK TSDWGTGFGG
60 70 80 90 100
KWTVKNTGTT SLSSWTVEWD FPSGTKVTSA WDATVTNSAD HWTAKNVGWN
110 120 130 140 150
GTLAPGASVS FGFNGSGPGS PSGCKINGGS CDGSSVPGDE APSAPGTPTA
160 170 180 190 200
SNITDTSVKL SWSAATDDKG VKNYDVLRDG ATVATVTGTT YTDNGLTKGT
210 220 230 240 250
DYSYSVKARD TGDQTGPASG SVKVTTTGGD GGEPNPNPGA EVKMGYFTNW
260 270 280 290 300
GVYGRNYHVK NLVTSGSAEK ITHINLRFGN VQGGKCTIGD AYADYDKAYT
310 320 330 340 350
ADQSVDGVAD TWDQPLRANF NQLRNLKAEY PHIKILYSFG GWTWSGGFPD
360 370 380 390 400
AVKNPAAFAK SCHDLVEDPR WADVFDGIDL DWEYPNACGL SCDETSAPNA
410 420 430 440 450
FSSMMKAMRA EFGQDYLITA AVTADGSDGG KIDAADYGEA SKYIDWYNVM
460 470 480 490 500
TYDFFGAWAK NGPTAPHSPL NAYDGIPQQG FTTADAMAKF KSKGVPADKL
510 520 530 540 550
LIGIGFYGRG WTGVTQSAPG GTATGPAAGT YEAGIEDYKV LKNSCPATGT
560 570 580 590 600
VAGTAYAHCG TNWWSYDTPA TIKSKMDWAE QQGLGGAFFW EFSGDTTNGE
610
LVSAIDSGLK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 3 | F → I in AAA26717 (PubMed:3275646).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M82804 Genomic DNA Translation: AAA26720.1 M18397 Genomic DNA Translation: AAA26717.1 |
PIRi | JH0573 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M82804 Genomic DNA Translation: AAA26720.1 M18397 Genomic DNA Translation: AAA26717.1 |
PIRi | JH0573 |
3D structure databases
SMRi | P11220 |
ModBasei | Search... |
Protein family/group databases
CAZyi | CBM2, Carbohydrate-Binding Module Family 2 GH18, Glycoside Hydrolase Family 18 |
Proteomic databases
PRIDEi | P11220 |
Family and domain databases
CDDi | cd00063, FN3, 1 hit |
Gene3Di | 2.60.40.10, 1 hit 2.60.40.290, 1 hit 3.10.50.10, 1 hit |
InterProi | View protein in InterPro IPR001919, CBD2 IPR008965, CBM2/CBM3_carb-bd_dom_sf IPR012291, CBM2_carb-bd_dom_sf IPR018366, CBM2_CS IPR011583, Chitinase_II IPR029070, Chitinase_insertion_sf IPR003961, FN3_dom IPR036116, FN3_sf IPR001223, Glyco_hydro18_cat IPR001579, Glyco_hydro_18_chit_AS IPR017853, Glycoside_hydrolase_SF IPR013783, Ig-like_fold |
Pfami | View protein in Pfam PF00553, CBM_2, 1 hit PF00041, fn3, 1 hit PF00704, Glyco_hydro_18, 1 hit |
SMARTi | View protein in SMART SM00637, CBD_II, 1 hit SM00060, FN3, 1 hit SM00636, Glyco_18, 1 hit |
SUPFAMi | SSF49265, SSF49265, 1 hit SSF49384, SSF49384, 1 hit SSF51445, SSF51445, 1 hit SSF54556, SSF54556, 1 hit |
PROSITEi | View protein in PROSITE PS51173, CBM2, 1 hit PS00561, CBM2_A, 1 hit PS00018, EF_HAND_1, 1 hit PS50853, FN3, 1 hit PS01095, GH18_1, 1 hit PS51910, GH18_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CHIT_STRPL | |
Accessioni | P11220Primary (citable) accession number: P11220 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | December 1, 1992 | |
Last modified: | February 23, 2022 | |
This is version 125 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- Glycosyl hydrolases
Classification of glycosyl hydrolase families and list of entries - SIMILARITY comments
Index of protein domains and families