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UniProtKB - P11220 (CHIT_STRPL)

Entry version 123 (26 Feb 2020)
Sequence version 2 (01 Dec 1992)
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Protein

Chitinase 63

Gene

chtA

Organism
Streptomyces plicatus
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins. EC:3.2.1.14

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei383Proton donorPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei384ChitooligosaccharidePROSITE-ProRule annotation1
Binding sitei590ChitooligosaccharidePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Chitin degradation, Polysaccharide degradation
LigandChitin-binding

Protein family/group databases

Carbohydrate-Active enZymes

More...CAZyi		CBM2, Carbohydrate-Binding Module Family 2
GH18, Glycoside Hydrolase Family 18

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chitinase 63 (EC:3.2.1.14)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:chtA
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStreptomyces plicatus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1922 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Actinobacteria › Streptomycetales › Streptomycetaceae › Streptomyces

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 301 PublicationAdd BLAST30
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001191231 – 610Chitinase 63Add BLAST580

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		P11220

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By chitin.

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P11220

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 134CBM2PROSITE-ProRule annotationAdd BLAST104
Domaini144 – 229Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST86
Domaini241 – 610GH18PROSITE-ProRule annotationAdd BLAST370

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni313 – 314Chitooligosaccharide bindingPROSITE-ProRule annotation2
Regioni340 – 343Chitooligosaccharide bindingPROSITE-ProRule annotation4
Regioni450 – 453Chitooligosaccharide bindingPROSITE-ProRule annotation4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

Conserved Domains Database

More...CDDi		cd00063, FN3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 1 hit
2.60.40.290, 1 hit
3.10.50.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001919, CBD2
IPR008965, CBM2/CBM3_carb-bd_dom_sf
IPR012291, CBM2_carb-bd_dom_sf
IPR018366, CBM2_CS
IPR011583, Chitinase_II
IPR029070, Chitinase_insertion_sf
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR001223, Glyco_hydro18_cat
IPR001579, Glyco_hydro_18_chit_AS
IPR017853, Glycoside_hydrolase_SF
IPR013783, Ig-like_fold

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00553, CBM_2, 1 hit
PF00041, fn3, 1 hit
PF00704, Glyco_hydro_18, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00637, CBD_II, 1 hit
SM00060, FN3, 1 hit
SM00636, Glyco_18, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49265, SSF49265, 1 hit
SSF49384, SSF49384, 1 hit
SSF51445, SSF51445, 1 hit
SSF54556, SSF54556, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51173, CBM2, 1 hit
PS00561, CBM2_A, 1 hit
PS00018, EF_HAND_1, 1 hit
PS50853, FN3, 1 hit
PS01095, GH18_1, 1 hit
PS51910, GH18_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P11220-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRFRHKAAAL AATLALPLAG LVGLASPAQA ATSATATFQK TSDWGTGFGG 
        60         70         80         90        100
KWTVKNTGTT SLSSWTVEWD FPSGTKVTSA WDATVTNSAD HWTAKNVGWN 
       110        120        130        140        150
GTLAPGASVS FGFNGSGPGS PSGCKINGGS CDGSSVPGDE APSAPGTPTA 
       160        170        180        190        200
SNITDTSVKL SWSAATDDKG VKNYDVLRDG ATVATVTGTT YTDNGLTKGT 
       210        220        230        240        250
DYSYSVKARD TGDQTGPASG SVKVTTTGGD GGEPNPNPGA EVKMGYFTNW 
       260        270        280        290        300
GVYGRNYHVK NLVTSGSAEK ITHINLRFGN VQGGKCTIGD AYADYDKAYT 
       310        320        330        340        350
ADQSVDGVAD TWDQPLRANF NQLRNLKAEY PHIKILYSFG GWTWSGGFPD 
       360        370        380        390        400
AVKNPAAFAK SCHDLVEDPR WADVFDGIDL DWEYPNACGL SCDETSAPNA 
       410        420        430        440        450
FSSMMKAMRA EFGQDYLITA AVTADGSDGG KIDAADYGEA SKYIDWYNVM 
       460        470        480        490        500
TYDFFGAWAK NGPTAPHSPL NAYDGIPQQG FTTADAMAKF KSKGVPADKL 
       510        520        530        540        550
LIGIGFYGRG WTGVTQSAPG GTATGPAAGT YEAGIEDYKV LKNSCPATGT 
       560        570        580        590        600
VAGTAYAHCG TNWWSYDTPA TIKSKMDWAE QQGLGGAFFW EFSGDTTNGE 
       610
LVSAIDSGLK
Length:610
Mass (Da):63,974
Last modified:December 1, 1992 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6A202EF361CCD500
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti3F → I in AAA26717 (PubMed:3275646).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M82804 Genomic DNA Translation: AAA26720.1
M18397 Genomic DNA Translation: AAA26717.1

Protein sequence database of the Protein Information Resource

More...PIRi		JH0573

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M82804 Genomic DNA Translation: AAA26720.1
M18397 Genomic DNA Translation: AAA26717.1
PIRiJH0573

3D structure databases

SMRiP11220
ModBaseiSearch...

Protein family/group databases

CAZyiCBM2, Carbohydrate-Binding Module Family 2
GH18, Glycoside Hydrolase Family 18

Proteomic databases

PRIDEiP11220

Family and domain databases

CDDicd00063, FN3, 1 hit
Gene3Di2.60.40.10, 1 hit
2.60.40.290, 1 hit
3.10.50.10, 1 hit
InterProiView protein in InterPro
IPR001919, CBD2
IPR008965, CBM2/CBM3_carb-bd_dom_sf
IPR012291, CBM2_carb-bd_dom_sf
IPR018366, CBM2_CS
IPR011583, Chitinase_II
IPR029070, Chitinase_insertion_sf
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR001223, Glyco_hydro18_cat
IPR001579, Glyco_hydro_18_chit_AS
IPR017853, Glycoside_hydrolase_SF
IPR013783, Ig-like_fold
PfamiView protein in Pfam
PF00553, CBM_2, 1 hit
PF00041, fn3, 1 hit
PF00704, Glyco_hydro_18, 1 hit
SMARTiView protein in SMART
SM00637, CBD_II, 1 hit
SM00060, FN3, 1 hit
SM00636, Glyco_18, 1 hit
SUPFAMiSSF49265, SSF49265, 1 hit
SSF49384, SSF49384, 1 hit
SSF51445, SSF51445, 1 hit
SSF54556, SSF54556, 1 hit
PROSITEiView protein in PROSITE
PS51173, CBM2, 1 hit
PS00561, CBM2_A, 1 hit
PS00018, EF_HAND_1, 1 hit
PS50853, FN3, 1 hit
PS01095, GH18_1, 1 hit
PS51910, GH18_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCHIT_STRPL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P11220
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: December 1, 1992
Last modified: February 26, 2020
This is version 123 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
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