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Protein

Integrin alpha-M

Gene

ITGAM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (PubMed:9558116, PubMed:20008295). It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration (PubMed:28807980). In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407). May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity). May play a role in mast cell development (By similarity).By similarityCurated4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi465 – 473Sequence analysis9
Calcium bindingi529 – 537Sequence analysis9
Calcium bindingi592 – 600Sequence analysis9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • amyloid-beta binding Source: ARUK-UCL
  • cargo receptor activity Source: ARUK-UCL
  • complement component C3b binding Source: ARUK-UCL
  • heat shock protein binding Source: CAFA
  • metal ion binding Source: UniProtKB-KW
  • protein heterodimerization activity Source: ARUK-UCL

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIntegrin, Receptor
Biological processCell adhesion, Immunity, Innate immunity
LigandCalcium, Magnesium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-216083 Integrin cell surface interactions
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-6798695 Neutrophil degranulation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P11215

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P11215

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Integrin alpha-M
Alternative name(s):
CD11 antigen-like family member B
CR-3 alpha chain
Cell surface glycoprotein MAC-1 subunit alpha
Leukocyte adhesion receptor MO1
Neutrophil adherence receptor
CD_antigen: CD11b
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ITGAM
Synonyms:CD11B, CR3A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000169896.16

Human Gene Nomenclature Database

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HGNCi
HGNC:6149 ITGAM

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
120980 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P11215

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini17 – 1104ExtracellularSequence analysisAdd BLAST1088
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1105 – 1128HelicalSequence analysisAdd BLAST24
Topological domaini1129 – 1152CytoplasmicSequence analysisAdd BLAST24

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Systemic lupus erythematosus 6 (SLEB6)2 Publications
Disease susceptibility may be associated with variations affecting the gene represented in this entry.
Disease descriptionA chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
See also OMIM:609939

Keywords - Diseasei

Systemic lupus erythematosus

Organism-specific databases

DisGeNET

More...
DisGeNETi
3684

MalaCards human disease database

More...
MalaCardsi
ITGAM
MIMi609939 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000169896

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
536 Systemic lupus erythematosus

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA29949

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3826

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
ITGAM

Domain mapping of disease mutations (DMDM)

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DMDMi
1708572

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 161 PublicationAdd BLAST16
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001628917 – 1152Integrin alpha-MAdd BLAST1136

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi66 ↔ 73By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi86N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi105 ↔ 123By similarity
Glycosylationi240N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi391N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi469N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi654 ↔ 711By similarity
Glycosylationi692N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi696N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi734N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi770 ↔ 776By similarity
Glycosylationi801N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi847 ↔ 864By similarity
Glycosylationi880N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi900N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi911N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi940N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi946N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi978N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi993N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi998 ↔ 1022By similarity
Glycosylationi1021N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1027 ↔ 1032By similarity
Glycosylationi1044N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1050N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1075N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P11215

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P11215

MaxQB - The MaxQuant DataBase

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MaxQBi
P11215

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P11215

PeptideAtlas

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PeptideAtlasi
P11215

PRoteomics IDEntifications database

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PRIDEi
P11215

ProteomicsDB human proteome resource

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ProteomicsDBi
52719

PTM databases

GlyConnect protein glycosylation platform

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GlyConnecti
1411

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P11215

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P11215

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in monocytes and granulocytes (PubMed:1346576). Expressed in neutrophils (at protein level) (PubMed:21193407).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000169896 Expressed in 188 organ(s), highest expression level in bone marrow cell

CleanEx database of gene expression profiles

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CleanExi
HS_ITGAM

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P11215 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P11215 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB025091
CAB072870
HPA002274

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of an alpha and a beta subunit. ITGAM associates with ITGB2. Found in a complex with CD177 and ITGB2/CD18 (PubMed:21193407). Interacts with JAM3 (PubMed:15194813, PubMed:12208882). Interacts with THBD (PubMed:27055590). Interacts with complement factor H/CFH; this interaction mediates adhesion of neutrophils to pathogens leading to pathogen clearance.6 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
109890, 10 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-1826 Integrin alphaM-beta2 complex

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P11215

Protein interaction database and analysis system

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IntActi
P11215, 31 interactors

Molecular INTeraction database

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MINTi
P11215

STRING: functional protein association networks

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STRINGi
9606.ENSP00000441691

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P11215

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11152
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A8Xmodel-A17-1152[»]
1BHOX-ray2.701/2149-337[»]
1BHQX-ray2.701/2149-337[»]
1IDNX-ray2.701/2149-337[»]
1IDOX-ray1.70A143-331[»]
1JLMX-ray2.00A143-334[»]
1M1UX-ray2.30A139-331[»]
1MF7X-ray1.25A144-333[»]
1N9ZX-ray2.50A144-335[»]
1NA5X-ray1.50A144-335[»]
2LKENMR-A1129-1152[»]
2LKJNMR-A1129-1152[»]
3Q3GX-ray2.70E/G/I/L148-337[»]
3QA3X-ray3.00E/G/I/L148-337[»]
4M76X-ray2.80B143-337[»]
4XW2X-ray2.00A145-337[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P11215

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P11215

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P11215

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati18 – 75FG-GAP 1PROSITE-ProRule annotationAdd BLAST58
Repeati76 – 135FG-GAP 2PROSITE-ProRule annotationAdd BLAST60
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini150 – 328VWFAPROSITE-ProRule annotationAdd BLAST179
Repeati339 – 390FG-GAP 3PROSITE-ProRule annotationAdd BLAST52
Repeati391 – 442FG-GAP 4PROSITE-ProRule annotationAdd BLAST52
Repeati443 – 503FG-GAP 5PROSITE-ProRule annotationAdd BLAST61
Repeati506 – 564FG-GAP 6PROSITE-ProRule annotationAdd BLAST59
Repeati569 – 629FG-GAP 7PROSITE-ProRule annotationAdd BLAST61

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1131 – 1135GFFKR motif5

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IPBA Eukaryota
ENOG410ZFBE LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000161282

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000113114

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG100530

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P11215

KEGG Orthology (KO)

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KOi
K06461

Identification of Orthologs from Complete Genome Data

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OMAi
MMSEGGP

Database of Orthologous Groups

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OrthoDBi
73876at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P11215

TreeFam database of animal gene trees

More...
TreeFami
TF105391

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.130.10.130, 1 hit
3.40.50.410, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR018184 Integrin_alpha_C_CS
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf
IPR002035 VWF_A
IPR036465 vWFA_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01839 FG-GAP, 1 hit
PF00357 Integrin_alpha, 1 hit
PF08441 Integrin_alpha2, 1 hit
PF00092 VWA, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01185 INTEGRINA

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00191 Int_alpha, 5 hits
SM00327 VWA, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF53300 SSF53300, 1 hit
SSF69179 SSF69179, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51470 FG_GAP, 7 hits
PS00242 INTEGRIN_ALPHA, 1 hit
PS50234 VWFA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P11215-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALRVLLLTA LTLCHGFNLD TENAMTFQEN ARGFGQSVVQ LQGSRVVVGA
60 70 80 90 100
PQEIVAANQR GSLYQCDYST GSCEPIRLQV PVEAVNMSLG LSLAATTSPP
110 120 130 140 150
QLLACGPTVH QTCSENTYVK GLCFLFGSNL RQQPQKFPEA LRGCPQEDSD
160 170 180 190 200
IAFLIDGSGS IIPHDFRRMK EFVSTVMEQL KKSKTLFSLM QYSEEFRIHF
210 220 230 240 250
TFKEFQNNPN PRSLVKPITQ LLGRTHTATG IRKVVRELFN ITNGARKNAF
260 270 280 290 300
KILVVITDGE KFGDPLGYED VIPEADREGV IRYVIGVGDA FRSEKSRQEL
310 320 330 340 350
NTIASKPPRD HVFQVNNFEA LKTIQNQLRE KIFAIEGTQT GSSSSFEHEM
360 370 380 390 400
SQEGFSAAIT SNGPLLSTVG SYDWAGGVFL YTSKEKSTFI NMTRVDSDMN
410 420 430 440 450
DAYLGYAAAI ILRNRVQSLV LGAPRYQHIG LVAMFRQNTG MWESNANVKG
460 470 480 490 500
TQIGAYFGAS LCSVDVDSNG STDLVLIGAP HYYEQTRGGQ VSVCPLPRGR
510 520 530 540 550
ARWQCDAVLY GEQGQPWGRF GAALTVLGDV NGDKLTDVAI GAPGEEDNRG
560 570 580 590 600
AVYLFHGTSG SGISPSHSQR IAGSKLSPRL QYFGQSLSGG QDLTMDGLVD
610 620 630 640 650
LTVGAQGHVL LLRSQPVLRV KAIMEFNPRE VARNVFECND QVVKGKEAGE
660 670 680 690 700
VRVCLHVQKS TRDRLREGQI QSVVTYDLAL DSGRPHSRAV FNETKNSTRR
710 720 730 740 750
QTQVLGLTQT CETLKLQLPN CIEDPVSPIV LRLNFSLVGT PLSAFGNLRP
760 770 780 790 800
VLAEDAQRLF TALFPFEKNC GNDNICQDDL SITFSFMSLD CLVVGGPREF
810 820 830 840 850
NVTVTVRNDG EDSYRTQVTF FFPLDLSYRK VSTLQNQRSQ RSWRLACESA
860 870 880 890 900
SSTEVSGALK STSCSINHPI FPENSEVTFN ITFDVDSKAS LGNKLLLKAN
910 920 930 940 950
VTSENNMPRT NKTEFQLELP VKYAVYMVVT SHGVSTKYLN FTASENTSRV
960 970 980 990 1000
MQHQYQVSNL GQRSLPISLV FLVPVRLNQT VIWDRPQVTF SENLSSTCHT
1010 1020 1030 1040 1050
KERLPSHSDF LAELRKAPVV NCSIAVCQRI QCDIPFFGIQ EEFNATLKGN
1060 1070 1080 1090 1100
LSFDWYIKTS HNHLLIVSTA EILFNDSVFT LLPGQGAFVR SQTETKVEPF
1110 1120 1130 1140 1150
EVPNPLPLIV GSSVGGLLLL ALITAALYKL GFFKRQYKDM MSEGGPPGAE

PQ
Length:1,152
Mass (Da):127,179
Last modified:October 1, 1996 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDF77408ED5EE25F9
GO
Isoform 2 (identifier: P11215-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     499-499: G → GQ

Show »
Length:1,153
Mass (Da):127,307
Checksum:i4383332408BB4234
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3NI33I3NI33_HUMAN
Integrin alpha-M
ITGAM
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BMV4H3BMV4_HUMAN
Integrin alpha-M
ITGAM
165Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti965L → P in AAA59491 (PubMed:2833753).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04387077R → H Influences susceptibility to SLE. 2 PublicationsCorresponds to variant dbSNP:rs1143679Ensembl.1
Natural variantiVAR_043871441M → T1 PublicationCorresponds to variant dbSNP:rs1143680Ensembl.1
Natural variantiVAR_043872858A → V1 PublicationCorresponds to variant dbSNP:rs1143683Ensembl.1
Natural variantiVAR_0438731146P → S1 PublicationCorresponds to variant dbSNP:rs1143678Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_047365499G → GQ in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J03925 mRNA Translation: AAA59544.1
M18044 mRNA Translation: AAA59491.1
S52227
, S52152, S52153, S52154, S52155, S52157, S52159, S52161, S52164, S52165, S52167, S52169, S52170, S52173, S52174, S52180, S52181, S52184, S52189, S52191, S52192, S52203, S52212, S52213, S52216, S52219, S52220, S52221, S52222, S52226 Genomic DNA Translation: AAB24821.1
BC096346 mRNA Translation: AAH96346.1
BC096347 mRNA Translation: AAH96347.1
BC096348 mRNA Translation: AAH96348.1
BC099660 mRNA Translation: AAH99660.1
J04145 mRNA Translation: AAA59903.1
M76724 Genomic DNA Translation: AAA58410.1
M84477 Genomic DNA Translation: AAA51960.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS45470.1 [P11215-1]
CCDS54004.1 [P11215-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
A31108 RWHU1B

NCBI Reference Sequences

More...
RefSeqi
NP_000623.2, NM_000632.3 [P11215-1]
NP_001139280.1, NM_001145808.1 [P11215-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.172631

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000287497; ENSP00000287497; ENSG00000169896 [P11215-1]
ENST00000544665; ENSP00000441691; ENSG00000169896 [P11215-2]
ENST00000648685; ENSP00000496959; ENSG00000169896 [P11215-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3684

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3684

UCSC genome browser

More...
UCSCi
uc002ebq.4 human [P11215-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03925 mRNA Translation: AAA59544.1
M18044 mRNA Translation: AAA59491.1
S52227
, S52152, S52153, S52154, S52155, S52157, S52159, S52161, S52164, S52165, S52167, S52169, S52170, S52173, S52174, S52180, S52181, S52184, S52189, S52191, S52192, S52203, S52212, S52213, S52216, S52219, S52220, S52221, S52222, S52226 Genomic DNA Translation: AAB24821.1
BC096346 mRNA Translation: AAH96346.1
BC096347 mRNA Translation: AAH96347.1
BC096348 mRNA Translation: AAH96348.1
BC099660 mRNA Translation: AAH99660.1
J04145 mRNA Translation: AAA59903.1
M76724 Genomic DNA Translation: AAA58410.1
M84477 Genomic DNA Translation: AAA51960.1
CCDSiCCDS45470.1 [P11215-1]
CCDS54004.1 [P11215-2]
PIRiA31108 RWHU1B
RefSeqiNP_000623.2, NM_000632.3 [P11215-1]
NP_001139280.1, NM_001145808.1 [P11215-2]
UniGeneiHs.172631

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A8Xmodel-A17-1152[»]
1BHOX-ray2.701/2149-337[»]
1BHQX-ray2.701/2149-337[»]
1IDNX-ray2.701/2149-337[»]
1IDOX-ray1.70A143-331[»]
1JLMX-ray2.00A143-334[»]
1M1UX-ray2.30A139-331[»]
1MF7X-ray1.25A144-333[»]
1N9ZX-ray2.50A144-335[»]
1NA5X-ray1.50A144-335[»]
2LKENMR-A1129-1152[»]
2LKJNMR-A1129-1152[»]
3Q3GX-ray2.70E/G/I/L148-337[»]
3QA3X-ray3.00E/G/I/L148-337[»]
4M76X-ray2.80B143-337[»]
4XW2X-ray2.00A145-337[»]
ProteinModelPortaliP11215
SMRiP11215
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109890, 10 interactors
ComplexPortaliCPX-1826 Integrin alphaM-beta2 complex
CORUMiP11215
IntActiP11215, 31 interactors
MINTiP11215
STRINGi9606.ENSP00000441691

Chemistry databases

BindingDBiP11215
ChEMBLiCHEMBL3826

PTM databases

GlyConnecti1411
iPTMnetiP11215
PhosphoSitePlusiP11215

Polymorphism and mutation databases

BioMutaiITGAM
DMDMi1708572

Proteomic databases

EPDiP11215
jPOSTiP11215
MaxQBiP11215
PaxDbiP11215
PeptideAtlasiP11215
PRIDEiP11215
ProteomicsDBi52719

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000287497; ENSP00000287497; ENSG00000169896 [P11215-1]
ENST00000544665; ENSP00000441691; ENSG00000169896 [P11215-2]
ENST00000648685; ENSP00000496959; ENSG00000169896 [P11215-2]
GeneIDi3684
KEGGihsa:3684
UCSCiuc002ebq.4 human [P11215-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3684
DisGeNETi3684
EuPathDBiHostDB:ENSG00000169896.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ITGAM
HGNCiHGNC:6149 ITGAM
HPAiCAB025091
CAB072870
HPA002274
MalaCardsiITGAM
MIMi120980 gene
609939 phenotype
neXtProtiNX_P11215
OpenTargetsiENSG00000169896
Orphaneti536 Systemic lupus erythematosus
PharmGKBiPA29949

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IPBA Eukaryota
ENOG410ZFBE LUCA
GeneTreeiENSGT00940000161282
HOGENOMiHOG000113114
HOVERGENiHBG100530
InParanoidiP11215
KOiK06461
OMAiMMSEGGP
OrthoDBi73876at2759
PhylomeDBiP11215
TreeFamiTF105391

Enzyme and pathway databases

ReactomeiR-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-216083 Integrin cell surface interactions
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-6798695 Neutrophil degranulation
SignaLinkiP11215
SIGNORiP11215

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ITGAM human
EvolutionaryTraceiP11215

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Integrin_alpha_M

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3684

Protein Ontology

More...
PROi
PR:P11215

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000169896 Expressed in 188 organ(s), highest expression level in bone marrow cell
CleanExiHS_ITGAM
ExpressionAtlasiP11215 baseline and differential
GenevisibleiP11215 HS

Family and domain databases

Gene3Di2.130.10.130, 1 hit
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR018184 Integrin_alpha_C_CS
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF01839 FG-GAP, 1 hit
PF00357 Integrin_alpha, 1 hit
PF08441 Integrin_alpha2, 1 hit
PF00092 VWA, 1 hit
PRINTSiPR01185 INTEGRINA
SMARTiView protein in SMART
SM00191 Int_alpha, 5 hits
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF69179 SSF69179, 3 hits
PROSITEiView protein in PROSITE
PS51470 FG_GAP, 7 hits
PS00242 INTEGRIN_ALPHA, 1 hit
PS50234 VWFA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiITAM_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P11215
Secondary accession number(s): Q4VAK0, Q4VAK1, Q4VAK2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: October 1, 1996
Last modified: January 16, 2019
This is version 212 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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