UniProtKB - P11207 (V_PIV5)
Non-structural protein V
P/V
Functioni
Plays an essential role in the inhibition of host immune response. Prevents the establishment of cellular antiviral state by blocking interferon-alpha/beta (IFN-alpha/beta) production and signaling pathway. Interacts with host IFIH1/MDA5 and DHX58/LGP2 to inhibit the transduction pathway involved in the activation of IFN-beta promoter, thus protecting the virus against cell antiviral state. Efficiently blocks type I IFN signaling following infection by behaving as a substrate receptor for CUL4-DDB1 E3 ligase complex and targeting host STAT1 for proteasomal degradation.
4 PublicationsSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 171 | Zinc 1 | 1 | |
Metal bindingi | 190 | Zinc 1 | 1 | |
Metal bindingi | 194 | Zinc 2 | 1 | |
Metal bindingi | 206 | Zinc 2 | 1 | |
Metal bindingi | 208 | Zinc 2 | 1 | |
Metal bindingi | 211 | Zinc 2 | 1 | |
Metal bindingi | 215 | Zinc 1 | 1 | |
Metal bindingi | 218 | Zinc 1 | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- RNA binding Source: UniProtKB-KW
GO - Biological processi
- suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity Source: UniProtKB-KW
- suppression by virus of host type I interferon-mediated signaling pathway Source: UniProtKB-KW
- suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity Source: CACAO
Keywordsi
Names & Taxonomyi
Protein namesi | Recommended name: Non-structural protein V |
Gene namesi | Name:P/V |
Organismi | Parainfluenza virus 5 (strain W3) (PIV5) (Simian virus 5) |
Taxonomic identifieri | 11208 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Negarnaviricota › Haploviricotina › Monjiviricetes › Mononegavirales › Paramyxoviridae › Rubulavirinae › Orthorubulavirus › Mammalian orthorubulavirus 5 |
Virus hosti | Canis lupus familiaris (Dog) (Canis familiaris) [TaxID: 9615] Homo sapiens (Human) [TaxID: 9606] |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000142830 | 1 – 222 | Non-structural protein VAdd BLAST | 222 |
Interactioni
Subunit structurei
Interacts with host DDB1, STAT2 and IFIH1/MDA5.
5 PublicationsBinary interactionsi
P11207
Protein-protein interaction databases
DIPi | DIP-48759N |
IntActi | P11207, 12 interactors |
MINTi | P11207 |
Structurei
Secondary structure
3D structure databases
SMRi | P11207 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P11207 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 61 – 107 | DisorderedSequence analysisAdd BLAST | 47 |
Sequence similaritiesi
Family and domain databases
InterProi | View protein in InterPro IPR024279, Paramyx_V_Zn-bd IPR025909, Soyouz_module |
Pfami | View protein in Pfam PF14313, Soyouz_module, 1 hit PF13008, zf-Paramyx-P, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MDPTDLSFSP DEINKLIETG LNTVEYFTSQ QVTGTSSLGK NTIPPGVTGL
60 70 80 90 100
LTNAAEAKIQ ESTNHQKGSV GGGAKPKKPR PKIAIVPADD KTVPGKPIPN
110 120 130 140 150
PLLGLDSTPS TQTVLDLSGK TLPSGSYKGV KLAKFGKENL MTRFIEEPRE
160 170 180 190 200
NPIATSSPID FKRGRDTGGF HRREYSIGWV GDEVKVTEWC NPSCSPITAA
210 220
ARRFECTCHQ CPVTCSECER DT
RNA editingi
Partially edited. RNA editing at this position consists of an insertion of two guanine nucleotides. The sequence displayed here is the V protein, derived from the unedited RNA. The edited RNA gives rise to the P protein (AC P11208).
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03142 mRNA Translation: AAA47882.1 AF052755 Genomic RNA Translation: AAC95512.1 |
PIRi | A31594, MNNZSP |
Keywords - Coding sequence diversityi
RNA editingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03142 mRNA Translation: AAA47882.1 AF052755 Genomic RNA Translation: AAC95512.1 |
PIRi | A31594, MNNZSP |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2B5L | X-ray | 2.85 | C/D | 1-222 | [»] | |
2HYE | X-ray | 3.10 | B | 1-222 | [»] | |
2K48 | NMR | - | A | 95-108 | [»] | |
4I1S | X-ray | 2.29 | B | 168-219 | [»] | |
SMRi | P11207 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
DIPi | DIP-48759N |
IntActi | P11207, 12 interactors |
MINTi | P11207 |
Miscellaneous databases
EvolutionaryTracei | P11207 |
Family and domain databases
InterProi | View protein in InterPro IPR024279, Paramyx_V_Zn-bd IPR025909, Soyouz_module |
Pfami | View protein in Pfam PF14313, Soyouz_module, 1 hit PF13008, zf-Paramyx-P, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | V_PIV5 | |
Accessioni | P11207Primary (citable) accession number: P11207 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | July 1, 1989 | |
Last modified: | May 25, 2022 | |
This is version 121 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structureDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families