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Protein

Uridine 5'-monophosphate synthase

Gene

UMPS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 1 and 2 of the subpathway that synthesizes UMP from orotate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Uridine 5'-monophosphate synthase (UMPS)
  2. Uridine 5'-monophosphate synthase (UMPS), Orotidine 5'-phosphate decarboxylase (UMPS), Orotidine 5'-phosphate decarboxylase (UMPS)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei312For OMPdecase activity1 Publication1
Active sitei314For OMPdecase activity1 Publication1
Active sitei317For OMPdecase activity1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • identical protein binding Source: IntAct
  • orotate phosphoribosyltransferase activity Source: UniProtKB
  • orotidine-5'-phosphate decarboxylase activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDecarboxylase, Glycosyltransferase, Lyase, Multifunctional enzyme, Transferase
Biological processPyrimidine biosynthesis

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
4.1.1.23 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-500753 Pyrimidine biosynthesis

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P11172

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00070;UER00119

UPA00070;UER00120

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uridine 5'-monophosphate synthase
Short name:
UMP synthase
Including the following 2 domains:
Orotate phosphoribosyltransferase (EC:2.4.2.10)
Short name:
OPRT
Short name:
OPRTase
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Short name:
ODC
Alternative name(s):
OMPdecase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UMPS
ORF Names:OK/SW-cl.21
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000114491.13

Human Gene Nomenclature Database

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HGNCi
HGNC:12563 UMPS

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613891 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P11172

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Orotic aciduria 1 (ORAC1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.
See also OMIM:258900
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00680796R → G in ORAC1. 1 PublicationCorresponds to variant dbSNP:rs121917890EnsemblClinVar.1
Natural variantiVAR_006808109V → G in ORAC1. 1 PublicationCorresponds to variant dbSNP:rs121917892EnsemblClinVar.1
Natural variantiVAR_006810429G → R in ORAC1. 1 PublicationCorresponds to variant dbSNP:rs121917891EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi312D → N: Loss of OMPdecase activity. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
7372

MalaCards human disease database

More...
MalaCardsi
UMPS
MIMi258900 phenotype

Open Targets

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OpenTargetsi
ENSG00000114491

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
30 Hereditary orotic aciduria

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA363

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5216

Drug and drug target database

More...
DrugBanki
DB02890 6-Hydroxyuridine-5'-Phosphate
DB00544 Fluorouracil

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
UMPS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001396492 – 480Uridine 5'-monophosphate synthaseAdd BLAST479

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei37PhosphotyrosineCombined sources1
Modified residuei214PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P11172

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P11172

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P11172

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P11172

PeptideAtlas

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PeptideAtlasi
P11172

PRoteomics IDEntifications database

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PRIDEi
P11172

ProteomicsDB human proteome resource

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ProteomicsDBi
52713
52714 [P11172-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P11172

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P11172

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000114491 Expressed in 217 organ(s), highest expression level in placenta

CleanEx database of gene expression profiles

More...
CleanExi
HS_UMPS

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P11172 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P11172 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA036178
HPA036179

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
113218, 54 interactors

Database of interacting proteins

More...
DIPi
DIP-29595N

Protein interaction database and analysis system

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IntActi
P11172, 24 interactors

Molecular INTeraction database

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MINTi
P11172

STRING: functional protein association networks

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STRINGi
9606.ENSP00000232607

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P11172

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1480
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EAWX-ray2.88A/B190-480[»]
2JGYX-ray1.95A/B224-479[»]
2P1FX-ray1.76A190-480[»]
2QCCX-ray1.85A/B224-480[»]
2QCDX-ray2.03A/B224-480[»]
2QCEX-ray1.43A224-480[»]
2QCFX-ray1.22A224-480[»]
2QCGX-ray1.75A/B224-480[»]
2QCHX-ray1.95A/B224-480[»]
2QCLX-ray1.85A/B224-480[»]
2QCMX-ray1.67A224-480[»]
2QCNX-ray1.85A/B224-480[»]
2V30X-ray2.00A/B224-479[»]
2WNSX-ray1.90A/B7-203[»]
3BGGX-ray1.93A190-480[»]
3BGJX-ray2.00A/B190-480[»]
3BK0X-ray1.60A/B223-480[»]
3BVJX-ray1.80A/B190-480[»]
3DBPX-ray1.50A/B223-480[»]
3EWUX-ray1.60A/B224-480[»]
3EWWX-ray1.10A/B224-480[»]
3EWXX-ray1.40A224-480[»]
3EWYX-ray1.10A224-480[»]
3EWZX-ray1.40A/B/C/D224-480[»]
3EX1X-ray1.40A/B224-480[»]
3EX2X-ray1.55A/B224-480[»]
3EX3X-ray1.45A/B224-480[»]
3EX4X-ray1.24A224-480[»]
3EX6X-ray1.30A/B224-480[»]
3G3DX-ray1.70A/B190-480[»]
3G3MX-ray1.40A223-480[»]
3L0KX-ray1.34A/B224-480[»]
3L0NX-ray1.74A/B224-480[»]
3MI2X-ray1.20A/B223-480[»]
3MO7X-ray1.35A223-480[»]
3MW7X-ray2.32A/B190-480[»]
4HIBX-ray1.80A/B190-480[»]
4HKPX-ray1.75A/B190-480[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P11172

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P11172

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P11172

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 214OPRTaseAdd BLAST213
Regioni215 – 220Domain linker6
Regioni221 – 480OMPdecaseAdd BLAST260

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.Curated
In the C-terminal section; belongs to the OMP decarboxylase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1377 Eukaryota
COG0284 LUCA
COG0461 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000001856

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000213905

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG000870

KEGG Orthology (KO)

More...
KOi
K13421

Identification of Orthologs from Complete Genome Data

More...
OMAi
EQGGKDK

Database of Orthologous Groups

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OrthoDBi
1129049at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P11172

TreeFam database of animal gene trees

More...
TreeFami
TF314694

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06223 PRTases_typeI, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.20.20.70, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_01208 PyrE, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013785 Aldolase_TIM
IPR014732 OMPdecase
IPR018089 OMPdecase_AS
IPR001754 OMPdeCOase_dom
IPR023031 OPRT
IPR004467 Or_phspho_trans_dom
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
IPR011060 RibuloseP-bd_barrel

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00215 OMPdecase, 1 hit
PF00156 Pribosyltran, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00934 OMPdecase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51366 SSF51366, 1 hit
SSF53271 SSF53271, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00336 pyrE, 1 hit
TIGR01740 pyrF, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00156 OMPDECASE, 1 hit
PS00103 PUR_PYR_PR_TRANSFER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P11172-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVARAALGP LVTGLYDVQA FKFGDFVLKS GLSSPIYIDL RGIVSRPRLL
60 70 80 90 100
SQVADILFQT AQNAGISFDT VCGVPYTALP LATVICSTNQ IPMLIRRKET
110 120 130 140 150
KDYGTKRLVE GTINPGETCL IIEDVVTSGS SVLETVEVLQ KEGLKVTDAI
160 170 180 190 200
VLLDREQGGK DKLQAHGIRL HSVCTLSKML EILEQQKKVD AETVGRVKRF
210 220 230 240 250
IQENVFVAAN HNGSPLSIKE APKELSFGAR AELPRIHPVA SKLLRLMQKK
260 270 280 290 300
ETNLCLSADV SLARELLQLA DALGPSICML KTHVDILNDF TLDVMKELIT
310 320 330 340 350
LAKCHEFLIF EDRKFADIGN TVKKQYEGGI FKIASWADLV NAHVVPGSGV
360 370 380 390 400
VKGLQEVGLP LHRGCLLIAE MSSTGSLATG DYTRAAVRMA EEHSEFVVGF
410 420 430 440 450
ISGSRVSMKP EFLHLTPGVQ LEAGGDNLGQ QYNSPQEVIG KRGSDIIIVG
460 470 480
RGIISAADRL EAAEMYRKAA WEAYLSRLGV
Length:480
Mass (Da):52,222
Last modified:July 1, 1989 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD985CD566B72F5CA
GO
Isoform 2 (identifier: P11172-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-178: Missing.

Note: No experimental confirmation available.
Show »
Length:302
Mass (Da):33,051
Checksum:i4B88EE5A8DC6FA65
GO
Isoform 3 (identifier: P11172-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-92: Missing.

Show »
Length:388
Mass (Da):42,495
Checksum:i1AA9931DE4283ABB
GO
Isoform 4 (identifier: P11172-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-178: Missing.
     328-424: Missing.

Show »
Length:205
Mass (Da):22,922
Checksum:i464CD94C5FDD0E5A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PFD2E9PFD2_HUMAN
Uridine 5'-monophosphate synthase
UMPS
342Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WDG4F8WDG4_HUMAN
Uridine 5'-monophosphate synthase
UMPS
142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z303F2Z303_HUMAN
Uridine 5'-monophosphate synthase
UMPS
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z3P2F2Z3P2_HUMAN
Uridine 5'-monophosphate synthase
UMPS
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAB45710 differs from that shown. Reason: Erroneous termination at position 430. Translated as Gln.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti13T → G in AAA61256 (Ref. 11) Curated1
Sequence conflicti377L → Q in AAA61256 (Ref. 11) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02061430S → G1 PublicationCorresponds to variant dbSNP:rs17843776EnsemblClinVar.1
Natural variantiVAR_00680796R → G in ORAC1. 1 PublicationCorresponds to variant dbSNP:rs121917890EnsemblClinVar.1
Natural variantiVAR_006808109V → G in ORAC1. 1 PublicationCorresponds to variant dbSNP:rs121917892EnsemblClinVar.1
Natural variantiVAR_006809213G → A2 PublicationsCorresponds to variant dbSNP:rs1801019EnsemblClinVar.1
Natural variantiVAR_006810429G → R in ORAC1. 1 PublicationCorresponds to variant dbSNP:rs121917891EnsemblClinVar.1
Natural variantiVAR_020615446I → V1 PublicationCorresponds to variant dbSNP:rs3772809EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0092731 – 178Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST178
Alternative sequenceiVSP_0476111 – 92Missing in isoform 3. 1 PublicationAdd BLAST92
Alternative sequenceiVSP_047612328 – 424Missing in isoform 4. 1 PublicationAdd BLAST97

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
J03626 mRNA Translation: AAA61255.1
D86227 mRNA Translation: BAA19920.1
D86228 mRNA Translation: BAA19921.1
D86230 mRNA Translation: BAA19923.1
AB041359 Genomic DNA Translation: BAB20663.1
EU921891 mRNA Translation: ACH48229.1
EU921895 mRNA Translation: ACH48233.1
AB062285 mRNA Translation: BAB93468.1
CR456787 mRNA Translation: CAG33068.1
AL080099 mRNA Translation: CAB45710.3 Sequence problems.
AY691629 Genomic DNA Translation: AAT85801.1
AC022336 Genomic DNA No translation available.
BC000364 mRNA Translation: AAH00364.1
BC007511 mRNA Translation: AAH07511.1
M36661 mRNA Translation: AAA61256.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS3029.1 [P11172-1]

Protein sequence database of the Protein Information Resource

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PIRi
A30148

NCBI Reference Sequences

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RefSeqi
NP_000364.1, NM_000373.3 [P11172-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.2057

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000232607; ENSP00000232607; ENSG00000114491 [P11172-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
7372

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:7372

UCSC genome browser

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UCSCi
uc003ehl.5 human [P11172-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03626 mRNA Translation: AAA61255.1
D86227 mRNA Translation: BAA19920.1
D86228 mRNA Translation: BAA19921.1
D86230 mRNA Translation: BAA19923.1
AB041359 Genomic DNA Translation: BAB20663.1
EU921891 mRNA Translation: ACH48229.1
EU921895 mRNA Translation: ACH48233.1
AB062285 mRNA Translation: BAB93468.1
CR456787 mRNA Translation: CAG33068.1
AL080099 mRNA Translation: CAB45710.3 Sequence problems.
AY691629 Genomic DNA Translation: AAT85801.1
AC022336 Genomic DNA No translation available.
BC000364 mRNA Translation: AAH00364.1
BC007511 mRNA Translation: AAH07511.1
M36661 mRNA Translation: AAA61256.1
CCDSiCCDS3029.1 [P11172-1]
PIRiA30148
RefSeqiNP_000364.1, NM_000373.3 [P11172-1]
UniGeneiHs.2057

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EAWX-ray2.88A/B190-480[»]
2JGYX-ray1.95A/B224-479[»]
2P1FX-ray1.76A190-480[»]
2QCCX-ray1.85A/B224-480[»]
2QCDX-ray2.03A/B224-480[»]
2QCEX-ray1.43A224-480[»]
2QCFX-ray1.22A224-480[»]
2QCGX-ray1.75A/B224-480[»]
2QCHX-ray1.95A/B224-480[»]
2QCLX-ray1.85A/B224-480[»]
2QCMX-ray1.67A224-480[»]
2QCNX-ray1.85A/B224-480[»]
2V30X-ray2.00A/B224-479[»]
2WNSX-ray1.90A/B7-203[»]
3BGGX-ray1.93A190-480[»]
3BGJX-ray2.00A/B190-480[»]
3BK0X-ray1.60A/B223-480[»]
3BVJX-ray1.80A/B190-480[»]
3DBPX-ray1.50A/B223-480[»]
3EWUX-ray1.60A/B224-480[»]
3EWWX-ray1.10A/B224-480[»]
3EWXX-ray1.40A224-480[»]
3EWYX-ray1.10A224-480[»]
3EWZX-ray1.40A/B/C/D224-480[»]
3EX1X-ray1.40A/B224-480[»]
3EX2X-ray1.55A/B224-480[»]
3EX3X-ray1.45A/B224-480[»]
3EX4X-ray1.24A224-480[»]
3EX6X-ray1.30A/B224-480[»]
3G3DX-ray1.70A/B190-480[»]
3G3MX-ray1.40A223-480[»]
3L0KX-ray1.34A/B224-480[»]
3L0NX-ray1.74A/B224-480[»]
3MI2X-ray1.20A/B223-480[»]
3MO7X-ray1.35A223-480[»]
3MW7X-ray2.32A/B190-480[»]
4HIBX-ray1.80A/B190-480[»]
4HKPX-ray1.75A/B190-480[»]
ProteinModelPortaliP11172
SMRiP11172
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113218, 54 interactors
DIPiDIP-29595N
IntActiP11172, 24 interactors
MINTiP11172
STRINGi9606.ENSP00000232607

Chemistry databases

BindingDBiP11172
ChEMBLiCHEMBL5216
DrugBankiDB02890 6-Hydroxyuridine-5'-Phosphate
DB00544 Fluorouracil

PTM databases

iPTMnetiP11172
PhosphoSitePlusiP11172

Polymorphism and mutation databases

BioMutaiUMPS

Proteomic databases

EPDiP11172
jPOSTiP11172
MaxQBiP11172
PaxDbiP11172
PeptideAtlasiP11172
PRIDEiP11172
ProteomicsDBi52713
52714 [P11172-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
7372
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000232607; ENSP00000232607; ENSG00000114491 [P11172-1]
GeneIDi7372
KEGGihsa:7372
UCSCiuc003ehl.5 human [P11172-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7372
DisGeNETi7372
EuPathDBiHostDB:ENSG00000114491.13

GeneCards: human genes, protein and diseases

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GeneCardsi
UMPS
HGNCiHGNC:12563 UMPS
HPAiHPA036178
HPA036179
MalaCardsiUMPS
MIMi258900 phenotype
613891 gene
neXtProtiNX_P11172
OpenTargetsiENSG00000114491
Orphaneti30 Hereditary orotic aciduria
PharmGKBiPA363

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1377 Eukaryota
COG0284 LUCA
COG0461 LUCA
GeneTreeiENSGT00390000001856
HOGENOMiHOG000213905
HOVERGENiHBG000870
KOiK13421
OMAiEQGGKDK
OrthoDBi1129049at2759
PhylomeDBiP11172
TreeFamiTF314694

Enzyme and pathway databases

UniPathwayi
UPA00070;UER00119

UPA00070;UER00120

BRENDAi4.1.1.23 2681
ReactomeiR-HSA-500753 Pyrimidine biosynthesis
SIGNORiP11172

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
UMPS human
EvolutionaryTraceiP11172

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Uridine_monophosphate_synthetase

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
7372

Protein Ontology

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PROi
PR:P11172

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000114491 Expressed in 217 organ(s), highest expression level in placenta
CleanExiHS_UMPS
ExpressionAtlasiP11172 baseline and differential
GenevisibleiP11172 HS

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_01208 PyrE, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR014732 OMPdecase
IPR018089 OMPdecase_AS
IPR001754 OMPdeCOase_dom
IPR023031 OPRT
IPR004467 Or_phspho_trans_dom
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
IPR011060 RibuloseP-bd_barrel
PfamiView protein in Pfam
PF00215 OMPdecase, 1 hit
PF00156 Pribosyltran, 1 hit
SMARTiView protein in SMART
SM00934 OMPdecase, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
SSF53271 SSF53271, 1 hit
TIGRFAMsiTIGR00336 pyrE, 1 hit
TIGR01740 pyrF, 1 hit
PROSITEiView protein in PROSITE
PS00156 OMPDECASE, 1 hit
PS00103 PUR_PYR_PR_TRANSFER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUMPS_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P11172
Secondary accession number(s): B5LY68
, B5LY72, O00758, O00759, O00760, Q16862, Q9H3Q2, Q9UG49
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: January 16, 2019
This is version 208 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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