EPB41

Functionⁱ

Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127).

1 Publication

GO - Molecular functionⁱ

1-phosphatidylinositol binding
Source: UniProtKB
Inferred from direct assayⁱ
- "Phosphatidylinositol-4,5-biphosphate (PIP2) differentially regulates the interaction of human erythrocyte protein 4.1 (4.1R) with membrane proteins."
  An X., Zhang X., Debnath G., Baines A.J., Mohandas N.
  Biochemistry 45:5725-5732(2006) [PubMed] [Europe PMC] [Abstract]
actin binding Source: UniProtKB-KW
calmodulin binding Source: UniProtKB-KW
phosphoprotein binding
Source: CAFA
Inferred from mutant phenotypeⁱ
- "NMR characterisation of the minimal interacting regions of centrosomal proteins 4.1R and NuMA1: effect of phosphorylation."
  Trevino M.A., Rodriguez-Rodriguez M., Correas I., Marcilla M., Albar J.P., Rico M., Jimenez M.A., Bruix M.
  BMC Biochem 11:7-7(2010) [PubMed] [Europe PMC] [Abstract]
protein C-terminus binding
Source: CAFA
Inferred from mutant phenotypeⁱ
- "NMR characterisation of the minimal interacting regions of centrosomal proteins 4.1R and NuMA1: effect of phosphorylation."
  Trevino M.A., Rodriguez-Rodriguez M., Correas I., Marcilla M., Albar J.P., Rico M., Jimenez M.A., Bruix M.
  BMC Biochem 11:7-7(2010) [PubMed] [Europe PMC] [Abstract]
protein N-terminus binding
Source: CAFA
Inferred from mutant phenotypeⁱ
- "NMR characterisation of the minimal interacting regions of centrosomal proteins 4.1R and NuMA1: effect of phosphorylation."
  Trevino M.A., Rodriguez-Rodriguez M., Correas I., Marcilla M., Albar J.P., Rico M., Jimenez M.A., Bruix M.
  BMC Biochem 11:7-7(2010) [PubMed] [Europe PMC] [Abstract]
spectrin binding
Source: BHF-UCL
Traceable author statementⁱ
- "Erythrocyte adducin: a calmodulin-regulated actin-bundling protein that stimulates spectrin-actin binding."
  Mische S.M., Mooseker M.S., Morrow J.S.
  J Cell Biol 105:2837-2845(1987) [PubMed] [Europe PMC] [Abstract]
structural constituent of cytoskeleton
Source: ProtInc
Traceable author statementⁱ
- "Deficiency of skeletal membrane protein band 4.1 in homozygous hereditary elliptocytosis. Implications for erythrocyte membrane stability."
  Tchernia G., Mohandas N., Shohet S.B.
  J Clin Invest 68:454-460(1981) [PubMed] [Europe PMC] [Abstract]

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Actin-binding, Calmodulin-binding
Biological process	Cell cycle, Cell division, Mitosis, Transport

Enzyme and pathway databases

PathwayCommonsⁱ	P11171
Reactomeⁱ	R-HSA-6794361, Neurexins and neuroligins
SignaLinkⁱ	P11171
SIGNORⁱ	P11171

Protein family/group databases

TCDBⁱ	8.A.25.1.2, the ezrin/radixin/moesin (ezrin) family

TCDBⁱ

8.A.25.1.2, the ezrin/radixin/moesin (ezrin) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein 4.1 Short name: P4.1 Alternative name(s): 4.1R Band 4.1 EPB4.1 Erythrocyte membrane protein band 4.1Imported
Gene namesⁱ	Name:EPB41Imported Synonyms:E41P
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3377, EPB41
MIMⁱ	130500, gene
neXtProtⁱ	NX_P11171
VEuPathDBⁱ	HostDB:ENSG00000159023

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Elliptocytosis 1 (EL1)1 Publication

The disease is caused by variants affecting the gene represented in this entry.

Disease descriptionA Rhesus-linked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape.

Related information in OMIM

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	60	T → A: Loss of CDK1-mediated phosphorylation. Abolishes targeting onto the mitotic spindle; when associated with A-712. 1 Publication		1
Mutagenesisⁱ	712	S → A: Loss of CDK1-mediated phosphorylation. Abolishes targeting onto the mitotic spindle; when associated with A-60. 1 Publication		1

Keywords - Diseaseⁱ

Elliptocytosis, Hereditary hemolytic anemia, Pyropoikilocytosis

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2035
MalaCards human disease database More...MalaCardsⁱ	EPB41
MIMⁱ	611804, phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000159023
Orphanetⁱ	288, Hereditary elliptocytosis
PharmGKBⁱ	PA27810

Miscellaneous databases

Pharosⁱ	P11171, Tbio

Pharosⁱ

P11171, Tbio

Genetic variation databases

BioMutaⁱ	EPB41
DMDMⁱ	90101808

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000219390	1 – 864	Protein 4.1Add BLAST		864

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	14	PhosphoserineCombined sources	1
Modified residueⁱ	60	Phosphothreonine; by CDK1Combined sources1 Publication	1
Modified residueⁱ	84	PhosphoserineCombined sources	1
Modified residueⁱ	85	PhosphoserineCombined sources	1
Modified residueⁱ	95	PhosphoserineCombined sources	1
Modified residueⁱ	104	PhosphoserineCombined sources	1
Modified residueⁱ	121	PhosphoserineBy similarity	1
Modified residueⁱ	149	PhosphoserineCombined sources	1
Modified residueⁱ	151	PhosphoserineCombined sources	1
Modified residueⁱ	152	PhosphoserineCombined sources	1
Modified residueⁱ	188	PhosphoserineCombined sources	1
Modified residueⁱ	191	PhosphoserineCombined sources	1
Modified residueⁱ	222	PhosphotyrosineBy similarity	1
Modified residueⁱ	378	PhosphothreonineCombined sources	1
Modified residueⁱ	521	PhosphoserineCombined sources	1
Modified residueⁱ	540	PhosphoserineCombined sources1 Publication	1
Modified residueⁱ	542	PhosphoserineCombined sources	1
Modified residueⁱ	555	PhosphoserineCombined sources	1
Modified residueⁱ	660	Phosphotyrosine; by EGFRCombined sources1 Publication	1
Modified residueⁱ	664	PhosphoserineBy similarity	1
Modified residueⁱ	674	PhosphoserineCombined sources	1
Modified residueⁱ	684	PhosphoserineCombined sources	1
Modified residueⁱ	709	PhosphoserineCombined sources1 Publication	1
Modified residueⁱ	712	Phosphoserine; by CDK1Combined sources1 Publication	1
Modified residueⁱ	736	PhosphothreonineCombined sources	1
Modified residueⁱ	859	PhosphothreonineCombined sources	1

Post-translational modificationⁱ

Phosphorylated at multiple sites by different protein kinases and each phosphorylation event selectively modulates the protein's functions.

Phosphorylation on Tyr-660 reduces the ability of 4.1 to promote the assembly of the spectrin/actin/4.1 ternary complex.1 Publication

O-glycosylated; contains N-acetylglucosamine side chains in the C-terminal domain.

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	P11171
jPOSTⁱ	P11171
MassIVEⁱ	P11171
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P11171
PaxDbⁱ	P11171
PeptideAtlas More...PeptideAtlasⁱ	P11171
PRIDEⁱ	P11171
ProteomicsDBⁱ	52706 [P11171-1] 52707 [P11171-2] 52708 [P11171-3] 52709 [P11171-4] 52710 [P11171-5] 52711 [P11171-6] 52712 [P11171-7]

PTM databases

GlyConnectⁱ	515, 1 O-Linked glycan (2 sites)
GlyGenⁱ	P11171, 4 sites, 1 O-linked glycan (4 sites)
iPTMnetⁱ	P11171
MetOSiteⁱ	P11171
PhosphoSitePlusⁱ	P11171

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000159023, Expressed in trabecular bone tissue and 224 other tissues
ExpressionAtlasⁱ	P11171, baseline and differential
Genevisibleⁱ	P11171, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000159023, Tissue enhanced (retina)

HPAⁱ

ENSG00000159023, Tissue enhanced (retina)

Interactionⁱ

Subunit structureⁱ

Binds with a high affinity to glycophorin and with lower affinity to band III protein. Associates with the nuclear mitotic apparatus.

Interacts with calmodulin (PubMed:10692436).

Interacts with CENPJ (PubMed:11003675).

Interacts with DLG1 (PubMed:7937897). Also found to associate with contractile apparatus and tight junctions.

Interacts with NUMA1; this interaction is negatively regulated by CDK1 during metaphase and promotes anaphase-specific localization of NUMA1 in symmetrically dividing cells (PubMed:23870127).

Interacts with ATP2B1; regulates small intestinal calcium absorption through regulation of membrane expression of ATP2B1 (By similarity).

By similarity4 Publications

Binary interactionsⁱ

Hide details

Isoform 2 [P11171-2]

With	#Exp.	IntAct
APP [P05067]	3	EBI-10197451,EBI-77613
CLNS1A [P54105]	3	EBI-10197451,EBI-724693
RWDD2B [P57060]	3	EBI-10197451,EBI-724442
ZCCHC10 [Q8TBK6]	3	EBI-10197451,EBI-597063

Isoform 7 [P11171-7]

With	#Exp.	IntAct
APP [P05067]	3	EBI-25852354,EBI-77613
CFAP100 - isoform 2 [Q494V2-2]	3	EBI-25852354,EBI-11953200

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	108349, 85 interactors
CORUMⁱ	P11171
Database of interacting proteins More...DIPⁱ	DIP-17032N
IntActⁱ	P11171, 22 interactors
Molecular INTeraction database More...MINTⁱ	P11171
STRINGⁱ	9606.ENSP00000345259

Miscellaneous databases

RNActⁱ	P11171, protein

RNActⁱ

P11171, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	211 – 215	Combined sources	5
Beta strandⁱ	221 – 225	Combined sources	5
Helixⁱ	232 – 243	Combined sources	12
Helixⁱ	248 – 250	Combined sources	3
Beta strandⁱ	251 – 258	Combined sources	8
Beta strandⁱ	261 – 264	Combined sources	4
Helixⁱ	271 – 274	Combined sources	4
Turnⁱ	275 – 277	Combined sources	3
Beta strandⁱ	281 – 288	Combined sources	8
Helixⁱ	293 – 295	Combined sources	3
Helixⁱ	299 – 314	Combined sources	16
Helixⁱ	322 – 337	Combined sources	16
Helixⁱ	342 – 345	Combined sources	4
Helixⁱ	350 – 352	Combined sources	3
Beta strandⁱ	356 – 358	Combined sources	3
Helixⁱ	361 – 372	Combined sources	12
Helixⁱ	379 – 390	Combined sources	12
Turnⁱ	394 – 397	Combined sources	4
Beta strandⁱ	399 – 404	Combined sources	6
Beta strandⁱ	410 – 415	Combined sources	6
Beta strandⁱ	417 – 424	Combined sources	8
Beta strandⁱ	427 – 433	Combined sources	7
Helixⁱ	434 – 436	Combined sources	3
Beta strandⁱ	437 – 443	Combined sources	7
Beta strandⁱ	446 – 451	Combined sources	6
Beta strandⁱ	454 – 458	Combined sources	5
Beta strandⁱ	461 – 466	Combined sources	6
Helixⁱ	470 – 486	Combined sources	17

Show more details

3D structure databases

BMRBⁱ	P11171
SMRⁱ	P11171
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P11171

EvolutionaryTraceⁱ

P11171

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	210 – 491	FERMPROSITE-ProRule annotationAdd BLAST		282

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	1 – 122	DisorderedSequence analysisAdd BLAST	122
Regionⁱ	136 – 170	DisorderedSequence analysisAdd BLAST	35
Regionⁱ	182 – 202	DisorderedSequence analysisAdd BLAST	21
Regionⁱ	494 – 614	HydrophilicAdd BLAST	121
Regionⁱ	518 – 572	DisorderedSequence analysisAdd BLAST	55
Regionⁱ	586 – 611	DisorderedSequence analysisAdd BLAST	26
Regionⁱ	615 – 713	Spectrin--actin-bindingAdd BLAST	99
Regionⁱ	714 – 864	C-terminal (CTD)Add BLAST	151

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	27 – 45	Polar residuesSequence analysisAdd BLAST	19
Compositional biasⁱ	57 – 77	Basic and acidic residuesSequence analysisAdd BLAST	21
Compositional biasⁱ	91 – 122	Basic and acidic residuesSequence analysisAdd BLAST	32

Phylogenomic databases

eggNOGⁱ	KOG3527, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000157833
HOGENOMⁱ	CLU_003623_0_1_1
InParanoidⁱ	P11171
OMAⁱ	EHHTFFX
Database of Orthologous Groups More...OrthoDBⁱ	1011028at2759
PhylomeDBⁱ	P11171
TreeFamⁱ	TF351626

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd14473, FERM_B-lobe, 1 hit
Database of protein disorder More...DisProtⁱ	DP00678
Gene3Dⁱ	1.20.80.10, 1 hit 2.30.29.30, 1 hit
InterProⁱ	View protein in InterPro IPR008379, Band_4.1_C IPR019749, Band_41_domain IPR021187, Band_41_protein_chordates IPR000798, Ez/rad/moesin-like IPR014847, FERM-adjacent IPR014352, FERM/acyl-CoA-bd_prot_sf IPR035963, FERM_2 IPR019748, FERM_central IPR019747, FERM_CS IPR000299, FERM_domain IPR018979, FERM_N IPR018980, FERM_PH-like_C IPR011993, PH-like_dom_sf IPR007477, SAB_dom IPR029071, Ubiquitin-like_domsf
PANTHERⁱ	PTHR23280:SF12, PTHR23280:SF12, 2 hits
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05902, 4_1_CTD, 1 hit PF08736, FA, 1 hit PF09380, FERM_C, 1 hit PF00373, FERM_M, 1 hit PF09379, FERM_N, 1 hit PF04382, SAB, 1 hit
PRINTSⁱ	PR00935, BAND41 PR00661, ERMFAMILY
SMARTⁱ	View protein in SMART SM00295, B41, 1 hit SM01195, FA, 1 hit SM01196, FERM_C, 1 hit
SUPFAMⁱ	SSF47031, SSF47031, 1 hit SSF54236, SSF54236, 1 hit
PROSITEⁱ	View protein in PROSITE PS00660, FERM_1, 1 hit PS00661, FERM_2, 1 hit PS50057, FERM_3, 1 hit

Sequences (7+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 7 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 7 described isoforms and 22 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P11171-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTTEKSLVTE AENSQHQQKE EGEEAINSGQ QEPQQEESCQ TAAEGDNWCE 
        60         70         80         90        100
QKLKASNGDT PTHEDLTKNK ERTSESRGLS RLFSSFLKRP KSQVSEEEGK 
       110        120        130        140        150
EVESDKEKGE GGQKEIEFGT SLDEEIILKA PIAAPEPELK TDPSLDLHSL 
       160        170        180        190        200
SSAETQPAQE ELREDPDFEI KEGEGLEECS KIEVKEESPQ SKAETELKAS 
       210        220        230        240        250
QKPIRKHRNM HCKVSLLDDT VYECVVEKHA KGQDLLKRVC EHLNLLEEDY 
       260        270        280        290        300
FGLAIWDNAT SKTWLDSAKE IKKQVRGVPW NFTFNVKFYP PDPAQLTEDI 
       310        320        330        340        350
TRYYLCLQLR QDIVAGRLPC SFATLALLGS YTIQSELGDY DPELHGVDYV 
       360        370        380        390        400
SDFKLAPNQT KELEEKVMEL HKSYRSMTPA QADLEFLENA KKLSMYGVDL 
       410        420        430        440        450
HKAKDLEGVD IILGVCSSGL LVYKDKLRIN RFPWPKVLKI SYKRSSFFIK 
       460        470        480        490        500
IRPGEQEQYE STIGFKLPSY RAAKKLWKVC VEHHTFFRLT STDTIPKSKF 
       510        520        530        540        550
LALGSKFRYS GRTQAQTRQA SALIDRPAPH FERTASKRAS RSLDGAAAVD 
       560        570        580        590        600
SADRSPRPTS APAITQGQVA EGGVLDASAK KTVVPKAQKE TVKAEVKKED 
       610        620        630        640        650
EPPEQAEPEP TEAWKVEKTH IEVTVPTSNG DQTQKLAEKT EDLIRMRKKK 
       660        670        680        690        700
RERLDGENIY IRHSNLMLED LDKSQEEIKK HHASISELKK NFMESVPEPR 
       710        720        730        740        750
PSEWDKRLST HSPFRTLNIN GQIPTGEGPP LVKTQTVTIS DNANAVKSEI 
       760        770        780        790        800
PTKDVPIVHT ETKTITYEAA QTDDNSGDLD PGVLLTAQTI TSETPSSTTT 
       810        820        830        840        850
TQITKTVKGG ISETRIEKRI VITGDADIDH DQVLVQAIKE AKEQHPDMSV 
       860 
TKVVVHQETE IADE

Length:864

Mass (Da):97,017

Last modified:March 7, 2006 - v4

Checksum:ⁱB466E7A9D7FBF12B

GO

Isoform 2 (identifier: P11171-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
616-648: Missing.

« Hide

        10         20         30         40         50
MTTEKSLVTE AENSQHQQKE EGEEAINSGQ QEPQQEESCQ TAAEGDNWCE 
        60         70         80         90        100
QKLKASNGDT PTHEDLTKNK ERTSESRGLS RLFSSFLKRP KSQVSEEEGK 
       110        120        130        140        150
EVESDKEKGE GGQKEIEFGT SLDEEIILKA PIAAPEPELK TDPSLDLHSL 
       160        170        180        190        200
SSAETQPAQE ELREDPDFEI KEGEGLEECS KIEVKEESPQ SKAETELKAS 
       210        220        230        240        250
QKPIRKHRNM HCKVSLLDDT VYECVVEKHA KGQDLLKRVC EHLNLLEEDY 
       260        270        280        290        300
FGLAIWDNAT SKTWLDSAKE IKKQVRGVPW NFTFNVKFYP PDPAQLTEDI 
       310        320        330        340        350
TRYYLCLQLR QDIVAGRLPC SFATLALLGS YTIQSELGDY DPELHGVDYV 
       360        370        380        390        400
SDFKLAPNQT KELEEKVMEL HKSYRSMTPA QADLEFLENA KKLSMYGVDL 
       410        420        430        440        450
HKAKDLEGVD IILGVCSSGL LVYKDKLRIN RFPWPKVLKI SYKRSSFFIK 
       460        470        480        490        500
IRPGEQEQYE STIGFKLPSY RAAKKLWKVC VEHHTFFRLT STDTIPKSKF 
       510        520        530        540        550
LALGSKFRYS GRTQAQTRQA SALIDRPAPH FERTASKRAS RSLDGAAAVD 
       560        570        580        590        600
SADRSPRPTS APAITQGQVA EGGVLDASAK KTVVPKAQKE TVKAEVKKED 
       610        620        630        640        650
EPPEQAEPEP TEAWKKKRER LDGENIYIRH SNLMLEDLDK SQEEIKKHHA 
       660        670        680        690        700
SISELKKNFM ESVPEPRPSE WDKRLSTHSP FRTLNINGQI PTGEGPPLVK 
       710        720        730        740        750
TQTVTISDNA NAVKSEIPTK DVPIVHTETK TITYEAAQTD DNSGDLDPGV 
       760        770        780        790        800
LLTAQTITSE TPSSTTTTQI TKTVKGGISE TRIEKRIVIT GDADIDHDQV 
       810        820        830 
LVQAIKEAKE QHPDMSVTKV VVHQETEIAD E

Show »

Length:831

Mass (Da):93,239

Checksum:ⁱE09038E1654F9248

GO

Isoform 3 (identifier: P11171-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-209: Missing.
635-648: Missing.

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        10         20         30         40         50
MHCKVSLLDD TVYECVVEKH AKGQDLLKRV CEHLNLLEED YFGLAIWDNA 
        60         70         80         90        100
TSKTWLDSAK EIKKQVRGVP WNFTFNVKFY PPDPAQLTED ITRYYLCLQL 
       110        120        130        140        150
RQDIVAGRLP CSFATLALLG SYTIQSELGD YDPELHGVDY VSDFKLAPNQ 
       160        170        180        190        200
TKELEEKVME LHKSYRSMTP AQADLEFLEN AKKLSMYGVD LHKAKDLEGV 
       210        220        230        240        250
DIILGVCSSG LLVYKDKLRI NRFPWPKVLK ISYKRSSFFI KIRPGEQEQY 
       260        270        280        290        300
ESTIGFKLPS YRAAKKLWKV CVEHHTFFRL TSTDTIPKSK FLALGSKFRY 
       310        320        330        340        350
SGRTQAQTRQ ASALIDRPAP HFERTASKRA SRSLDGAAAV DSADRSPRPT 
       360        370        380        390        400
SAPAITQGQV AEGGVLDASA KKTVVPKAQK ETVKAEVKKE DEPPEQAEPE 
       410        420        430        440        450
PTEAWKVEKT HIEVTVPTSN GDQTQKKRER LDGENIYIRH SNLMLEDLDK 
       460        470        480        490        500
SQEEIKKHHA SISELKKNFM ESVPEPRPSE WDKRLSTHSP FRTLNINGQI 
       510        520        530        540        550
PTGEGPPLVK TQTVTISDNA NAVKSEIPTK DVPIVHTETK TITYEAAQTD 
       560        570        580        590        600
DNSGDLDPGV LLTAQTITSE TPSSTTTTQI TKTVKGGISE TRIEKRIVIT 
       610        620        630        640 
GDADIDHDQV LVQAIKEAKE QHPDMSVTKV VVHQETEIAD E

Show »

Length:641

Mass (Da):71,955

Checksum:ⁱ0350A4E7EF6E8AE8

GO

Isoform 4 (identifier: P11171-4) [UniParc]FASTA Add to basket

Also known as: Erythroid

The sequence of this isoform differs from the canonical sequence as follows:
     1-209: Missing.
     616-648: Missing.
     772-805: Missing.

« Hide

        10         20         30         40         50
MHCKVSLLDD TVYECVVEKH AKGQDLLKRV CEHLNLLEED YFGLAIWDNA 
        60         70         80         90        100
TSKTWLDSAK EIKKQVRGVP WNFTFNVKFY PPDPAQLTED ITRYYLCLQL 
       110        120        130        140        150
RQDIVAGRLP CSFATLALLG SYTIQSELGD YDPELHGVDY VSDFKLAPNQ 
       160        170        180        190        200
TKELEEKVME LHKSYRSMTP AQADLEFLEN AKKLSMYGVD LHKAKDLEGV 
       210        220        230        240        250
DIILGVCSSG LLVYKDKLRI NRFPWPKVLK ISYKRSSFFI KIRPGEQEQY 
       260        270        280        290        300
ESTIGFKLPS YRAAKKLWKV CVEHHTFFRL TSTDTIPKSK FLALGSKFRY 
       310        320        330        340        350
SGRTQAQTRQ ASALIDRPAP HFERTASKRA SRSLDGAAAV DSADRSPRPT 
       360        370        380        390        400
SAPAITQGQV AEGGVLDASA KKTVVPKAQK ETVKAEVKKE DEPPEQAEPE 
       410        420        430        440        450
PTEAWKKKRE RLDGENIYIR HSNLMLEDLD KSQEEIKKHH ASISELKKNF 
       460        470        480        490        500
MESVPEPRPS EWDKRLSTHS PFRTLNINGQ IPTGEGPPLV KTQTVTISDN 
       510        520        530        540        550
ANAVKSEIPT KDVPIVHTET KTITYEAAQT VKGGISETRI EKRIVITGDA 
       560        570        580 
DIDHDQVLVQ AIKEAKEQHP DMSVTKVVVH QETEIADE

Show »

Length:588

Mass (Da):66,399

Checksum:ⁱD14399077034CFD5

GO

Isoform 5 (identifier: P11171-5) [UniParc]FASTA Add to basket

Also known as: Non-erythroid A

The sequence of this isoform differs from the canonical sequence as follows:
     228-262: Missing.
     616-648: Missing.
     649-669: Missing.

« Hide

        10         20         30         40         50
MTTEKSLVTE AENSQHQQKE EGEEAINSGQ QEPQQEESCQ TAAEGDNWCE 
        60         70         80         90        100
QKLKASNGDT PTHEDLTKNK ERTSESRGLS RLFSSFLKRP KSQVSEEEGK 
       110        120        130        140        150
EVESDKEKGE GGQKEIEFGT SLDEEIILKA PIAAPEPELK TDPSLDLHSL 
       160        170        180        190        200
SSAETQPAQE ELREDPDFEI KEGEGLEECS KIEVKEESPQ SKAETELKAS 
       210        220        230        240        250
QKPIRKHRNM HCKVSLLDDT VYECVVETWL DSAKEIKKQV RGVPWNFTFN 
       260        270        280        290        300
VKFYPPDPAQ LTEDITRYYL CLQLRQDIVA GRLPCSFATL ALLGSYTIQS 
       310        320        330        340        350
ELGDYDPELH GVDYVSDFKL APNQTKELEE KVMELHKSYR SMTPAQADLE 
       360        370        380        390        400
FLENAKKLSM YGVDLHKAKD LEGVDIILGV CSSGLLVYKD KLRINRFPWP 
       410        420        430        440        450
KVLKISYKRS SFFIKIRPGE QEQYESTIGF KLPSYRAAKK LWKVCVEHHT 
       460        470        480        490        500
FFRLTSTDTI PKSKFLALGS KFRYSGRTQA QTRQASALID RPAPHFERTA 
       510        520        530        540        550
SKRASRSLDG AAAVDSADRS PRPTSAPAIT QGQVAEGGVL DASAKKTVVP 
       560        570        580        590        600
KAQKETVKAE VKKEDEPPEQ AEPEPTEAWK DLDKSQEEIK KHHASISELK 
       610        620        630        640        650
KNFMESVPEP RPSEWDKRLS THSPFRTLNI NGQIPTGEGP PLVKTQTVTI 
       660        670        680        690        700
SDNANAVKSE IPTKDVPIVH TETKTITYEA AQTDDNSGDL DPGVLLTAQT 
       710        720        730        740        750
ITSETPSSTT TTQITKTVKG GISETRIEKR IVITGDADID HDQVLVQAIK 
       760        770 
EAKEQHPDMS VTKVVVHQET EIADE

Show »

Length:775

Mass (Da):86,603

Checksum:ⁱ4A2D98E32CF8552C

GO

Isoform 6 (identifier: P11171-6) [UniParc]FASTA Add to basket

Also known as: Non-erythroid B

The sequence of this isoform differs from the canonical sequence as follows:
     1-209: Missing.
     228-262: Missing.
     616-648: Missing.
     649-669: Missing.

« Hide

        10         20         30         40         50
MHCKVSLLDD TVYECVVETW LDSAKEIKKQ VRGVPWNFTF NVKFYPPDPA 
        60         70         80         90        100
QLTEDITRYY LCLQLRQDIV AGRLPCSFAT LALLGSYTIQ SELGDYDPEL 
       110        120        130        140        150
HGVDYVSDFK LAPNQTKELE EKVMELHKSY RSMTPAQADL EFLENAKKLS 
       160        170        180        190        200
MYGVDLHKAK DLEGVDIILG VCSSGLLVYK DKLRINRFPW PKVLKISYKR 
       210        220        230        240        250
SSFFIKIRPG EQEQYESTIG FKLPSYRAAK KLWKVCVEHH TFFRLTSTDT 
       260        270        280        290        300
IPKSKFLALG SKFRYSGRTQ AQTRQASALI DRPAPHFERT ASKRASRSLD 
       310        320        330        340        350
GAAAVDSADR SPRPTSAPAI TQGQVAEGGV LDASAKKTVV PKAQKETVKA 
       360        370        380        390        400
EVKKEDEPPE QAEPEPTEAW KDLDKSQEEI KKHHASISEL KKNFMESVPE 
       410        420        430        440        450
PRPSEWDKRL STHSPFRTLN INGQIPTGEG PPLVKTQTVT ISDNANAVKS 
       460        470        480        490        500
EIPTKDVPIV HTETKTITYE AAQTDDNSGD LDPGVLLTAQ TITSETPSST 
       510        520        530        540        550
TTTQITKTVK GGISETRIEK RIVITGDADI DHDQVLVQAI KEAKEQHPDM 
       560 
SVTKVVVHQE TEIADE

Show »

Length:566

Mass (Da):63,255

Checksum:ⁱ288A47844D5CCE62

GO

Isoform 7 (identifier: P11171-7) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     635-648: Missing.
     729-734: PPLVKT → VSTLST
     735-864: Missing.

« Hide

        10         20         30         40         50
MTTEKSLVTE AENSQHQQKE EGEEAINSGQ QEPQQEESCQ TAAEGDNWCE 
        60         70         80         90        100
QKLKASNGDT PTHEDLTKNK ERTSESRGLS RLFSSFLKRP KSQVSEEEGK 
       110        120        130        140        150
EVESDKEKGE GGQKEIEFGT SLDEEIILKA PIAAPEPELK TDPSLDLHSL 
       160        170        180        190        200
SSAETQPAQE ELREDPDFEI KEGEGLEECS KIEVKEESPQ SKAETELKAS 
       210        220        230        240        250
QKPIRKHRNM HCKVSLLDDT VYECVVEKHA KGQDLLKRVC EHLNLLEEDY 
       260        270        280        290        300
FGLAIWDNAT SKTWLDSAKE IKKQVRGVPW NFTFNVKFYP PDPAQLTEDI 
       310        320        330        340        350
TRYYLCLQLR QDIVAGRLPC SFATLALLGS YTIQSELGDY DPELHGVDYV 
       360        370        380        390        400
SDFKLAPNQT KELEEKVMEL HKSYRSMTPA QADLEFLENA KKLSMYGVDL 
       410        420        430        440        450
HKAKDLEGVD IILGVCSSGL LVYKDKLRIN RFPWPKVLKI SYKRSSFFIK 
       460        470        480        490        500
IRPGEQEQYE STIGFKLPSY RAAKKLWKVC VEHHTFFRLT STDTIPKSKF 
       510        520        530        540        550
LALGSKFRYS GRTQAQTRQA SALIDRPAPH FERTASKRAS RSLDGAAAVD 
       560        570        580        590        600
SADRSPRPTS APAITQGQVA EGGVLDASAK KTVVPKAQKE TVKAEVKKED 
       610        620        630        640        650
EPPEQAEPEP TEAWKVEKTH IEVTVPTSNG DQTQKKRERL DGENIYIRHS 
       660        670        680        690        700
NLMLEDLDKS QEEIKKHHAS ISELKKNFME SVPEPRPSEW DKRLSTHSPF 
       710        720
RTLNINGQIP TGEGVSTLST

Show »

Length:720

Mass (Da):81,235

Checksum:ⁱAE02E72F2EB18335

GO

Computationally mapped potential isoform sequencesⁱ

There are 22 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	A0A2R8YCW8	A0A2R8YCW8_HUMAN	Band 4.1 Band 4.1 (Erythrocyte membrane protein band 4.1) (Protein 4.1)	EPB41	748	Annotation score:
	A0A3B3IU06	A0A3B3IU06_HUMAN	Band 4.1 Band 4.1 (Erythrocyte membrane protein band 4.1) (Protein 4.1)	EPB41	807	Annotation score:
	A0A1B0GWG0	A0A1B0GWG0_HUMAN	Band 4.1 Band 4.1 (Erythrocyte membrane protein band 4.1) (Protein 4.1)	EPB41	483	Annotation score:
	A0A2R8Y7Y3	A0A2R8Y7Y3_HUMAN	Band 4.1 Band 4.1 (Erythrocyte membrane protein band 4.1) (Protein 4.1)	EPB41	601	Annotation score:
	A0A2U3TZH6	A0A2U3TZH6_HUMAN	Band 4.1 Band 4.1 (Erythrocyte membrane protein band 4.1) (Protein 4.1)	EPB41	841	Annotation score:
	A0A2R8Y7N0	A0A2R8Y7N0_HUMAN	Band 4.1 Band 4.1 (Erythrocyte membrane protein band 4.1) (Protein 4.1)	EPB41	565	Annotation score:
	A0A2R8Y5G2	A0A2R8Y5G2_HUMAN	Band 4.1 Band 4.1 (Erythrocyte membrane protein band 4.1) (Protein 4.1)	EPB41	782	Annotation score:
	A0A2R8Y6D0	A0A2R8Y6D0_HUMAN	Band 4.1 Band 4.1 (Erythrocyte membrane protein band 4.1) (Protein 4.1)	EPB41	542	Annotation score:
	A0A2R8Y570	A0A2R8Y570_HUMAN	Band 4.1 Band 4.1 (Erythrocyte membrane protein band 4.1) (Protein 4.1)	EPB41	766	Annotation score:
	A0A2R8Y5Z6	A0A2R8Y5Z6_HUMAN	Band 4.1 Band 4.1 (Erythrocyte membrane protein band 4.1) (Protein 4.1)	EPB41	787	Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	51	Q → H in AAD42222 (Ref. 5) Curated	1
Sequence conflictⁱ	76	S → N in AAD42222 (Ref. 5) Curated	1
Sequence conflictⁱ	168	F → S in AAD42223 (Ref. 9) Curated	1
Sequence conflictⁱ	259	A → T in AAD42222 (Ref. 5) Curated	1
Sequence conflictⁱ	665	N → S in AAD42222 (Ref. 5) Curated	1
Sequence conflictⁱ	669	E → K no nucleotide entry (PubMed:3194408).Curated	1
Sequence conflictⁱ	679	K → E in AAD42222 (Ref. 5) Curated	1
Sequence conflictⁱ	802	Q → K no nucleotide entry (PubMed:3223413).Curated	1
Sequence conflictⁱ	802	Q → K in AAA35793 (PubMed:3375238).Curated	1
Sequence conflictⁱ	802	Q → K in AAA35794 (PubMed:3375238).Curated	1
Sequence conflictⁱ	852	K → L no nucleotide entry (PubMed:3194408).Curated	1
Sequence conflictⁱ	863	D → E no nucleotide entry (PubMed:3194408).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_009122	214	V → I1 PublicationCorresponds to variant dbSNP:rs111642750EnsemblClinVar.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_000468	1 – 209	Missing in isoform 3, isoform 4 and isoform 6. 4 PublicationsAdd BLAST	209
Alternative sequenceⁱVSP_000469	228 – 262	Missing in isoform 5 and isoform 6. 2 PublicationsAdd BLAST	35
Alternative sequenceⁱVSP_000470	616 – 648	Missing in isoform 2, isoform 4, isoform 5 and isoform 6. 3 PublicationsAdd BLAST	33
Alternative sequenceⁱVSP_000471	635 – 648	Missing in isoform 3 and isoform 7. 2 PublicationsAdd BLAST	14
Alternative sequenceⁱVSP_000472	649 – 669	Missing in isoform 5 and isoform 6. 2 PublicationsAdd BLAST	21
Alternative sequenceⁱVSP_012872	729 – 734	PPLVKT → VSTLST in isoform 7. 1 Publication	6
Alternative sequenceⁱVSP_012873	735 – 864	Missing in isoform 7. 1 PublicationAdd BLAST	130
Alternative sequenceⁱVSP_000473	772 – 805	Missing in isoform 4. 1 PublicationAdd BLAST	34

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M14993 mRNA Translation: AAA35795.1 J03796 mRNA Translation: AAA35793.1 J03796 mRNA Translation: AAA35794.1 M61733 mRNA Translation: AAA35797.1 AF156225 mRNA Translation: AAD42222.1 AL138785 Genomic DNA No translation available. AL357500 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07663.1 CH471059 Genomic DNA Translation: EAX07665.1 CH471059 Genomic DNA Translation: EAX07667.1 CH471059 Genomic DNA Translation: EAX07668.1 BC039079 mRNA Translation: AAH39079.1 AF156226 Genomic DNA Translation: AAD42223.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS330.1 [P11171-5] CCDS331.1 [P11171-4] CCDS332.1 [P11171-3] CCDS53288.1 [P11171-1] CCDS53289.1 [P11171-7]
PIRⁱ	A39810, MMHUE4
NCBI Reference Sequences More...RefSeqⁱ	NP_001159477.1, NM_001166005.1 [P11171-1] NP_001159478.1, NM_001166006.1 [P11171-7] NP_004428.1, NM_004437.3 [P11171-4] NP_976217.1, NM_203342.2 [P11171-3] XP_005245818.1, XM_005245761.1 XP_005245821.1, XM_005245764.1 [P11171-2] XP_016856078.1, XM_017000589.1 [P11171-5]

Genome annotation databases

Ensemblⁱ	ENST00000343067; ENSP00000345259; ENSG00000159023 ENST00000347529; ENSP00000290100; ENSG00000159023 [P11171-5] ENST00000373797; ENSP00000362903; ENSG00000159023 [P11171-7] ENST00000373798; ENSP00000362904; ENSG00000159023 ENST00000373800; ENSP00000362906; ENSG00000159023 [P11171-4]
GeneIDⁱ	2035
KEGGⁱ	hsa:2035
MANE-Selectⁱ	ENST00000343067.9; ENSP00000345259.4; NM_001376013.1; NP_001362942.1
UCSC genome browser More...UCSCⁱ	uc001brg.3, human [P11171-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P11171	Band 4.1		HUMAN		655	UniRef100_P11171
P11171-2	Band 4.1		HUMAN		622	UniRef100_Q4VB86
Band 4.1 (Fragment)		HUMAN		742

Protein	Similar proteins		Species	Score	Length	Source
P11171	Band 4.1		HUMAN		655	UniRef90_P11171
Band 4.1		PANTR		864
Band 4.1		GORGO		864
Band 4.1		PANPA		864
Band 4.1		PONAB		864
+78
P11171-2	Band 4.1		MACMU		1035	UniRef90_F6W871
Band 4.1		CERAT		622
Band 4.1		RHIRO		622
Band 4.1		RHIBE		622
Erythrocyte membrane protein band 4.1		Ugandan red Colobus		622
+19
P11171-7	Band 4.1		GORGO		810	UniRef90_P11171-7
Band 4.1		PANTR		810
Band 4.1		PANPA		810
Band 4.1		HUMAN		787
Band 4.1		PONAB		720
+69

Protein	Similar proteins		Species	Score	Length	Source
P11171	Protein 4.1		MOUSE		858	UniRef50_P11171
Band 4.1		HUMAN		655
Band 4.1		PANPA		864
Band 4.1		PONAB		864
Band 4.1		GORGO		864
+501
P11171-2	Band 4.1		MACMU		1035	UniRef50_F6W871
Band 4.1		HUMAN		622
Band 4.1		CERAT		622
Band 4.1		RHIRO		622
Band 4.1		RHIBE		622
+125
P11171-4	Erythrocyte membrane protein band 4.1		BOSMU		582	UniRef50_P11171-4
Band 4.1		SALFA		613
Erythrocyte membrane protein band 4.1a		CYPCA		556
Band 4.1		KRYMA		676
Band 4.1 (Fragment)		Nothobranchius korthausae		623
+75
P11171-5	Isoform 6 of Protein 4.1		HUMAN		566	UniRef50_P11171-5
protein 4.1 isoform X13		HIPAR		657
Band 4.1		CALJA		775
Erythrocyte membrane protein band 4.1		PANTA		720
Erythrocyte membrane protein band 4.1		THEGE		776
+39
P11171-7	Protein 4.1		BOVIN		617	UniRef50_P11171-7
Band 4.1		PANPA		810
Band 4.1		GORGO		810
Band 4.1		PANTR		810
Band 4.1		HUMAN		787
+590

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M14993 mRNA Translation: AAA35795.1 J03796 mRNA Translation: AAA35793.1 J03796 mRNA Translation: AAA35794.1 M61733 mRNA Translation: AAA35797.1 AF156225 mRNA Translation: AAD42222.1 AL138785 Genomic DNA No translation available. AL357500 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07663.1 CH471059 Genomic DNA Translation: EAX07665.1 CH471059 Genomic DNA Translation: EAX07667.1 CH471059 Genomic DNA Translation: EAX07668.1 BC039079 mRNA Translation: AAH39079.1 AF156226 Genomic DNA Translation: AAD42223.1
CCDSⁱ	CCDS330.1 [P11171-5] CCDS331.1 [P11171-4] CCDS332.1 [P11171-3] CCDS53288.1 [P11171-1] CCDS53289.1 [P11171-7]
PIRⁱ	A39810, MMHUE4
RefSeqⁱ	NP_001159477.1, NM_001166005.1 [P11171-1] NP_001159478.1, NM_001166006.1 [P11171-7] NP_004428.1, NM_004437.3 [P11171-4] NP_976217.1, NM_203342.2 [P11171-3] XP_005245818.1, XM_005245761.1 XP_005245821.1, XM_005245764.1 [P11171-2] XP_016856078.1, XM_017000589.1 [P11171-5]

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1GG3	X-ray	2.80	A/B/C	210-488	[»]
	2RQ1	NMR	-	A	292-396	[»]
	3QIJ	X-ray	1.80	A/B	211-488	[»]
BMRBⁱ	P11171
SMRⁱ	P11171
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	108349, 85 interactors
CORUMⁱ	P11171
DIPⁱ	DIP-17032N
IntActⁱ	P11171, 22 interactors
MINTⁱ	P11171
STRINGⁱ	9606.ENSP00000345259

Protein family/group databases

TCDBⁱ	8.A.25.1.2, the ezrin/radixin/moesin (ezrin) family

TCDBⁱ

8.A.25.1.2, the ezrin/radixin/moesin (ezrin) family

PTM databases

GlyConnectⁱ	515, 1 O-Linked glycan (2 sites)
GlyGenⁱ	P11171, 4 sites, 1 O-linked glycan (4 sites)
iPTMnetⁱ	P11171
MetOSiteⁱ	P11171
PhosphoSitePlusⁱ	P11171

Genetic variation databases

BioMutaⁱ	EPB41
DMDMⁱ	90101808

Proteomic databases

EPDⁱ	P11171
jPOSTⁱ	P11171
MassIVEⁱ	P11171
MaxQBⁱ	P11171
PaxDbⁱ	P11171
PeptideAtlasⁱ	P11171
PRIDEⁱ	P11171
ProteomicsDBⁱ	52706 [P11171-1] 52707 [P11171-2] 52708 [P11171-3] 52709 [P11171-4] 52710 [P11171-5] 52711 [P11171-6] 52712 [P11171-7]

Protocols and materials databases

Antibodypediaⁱ	30998, 359 antibodies from 30 providers
The DNASU plasmid repository More...DNASUⁱ	2035

Genome annotation databases

Ensemblⁱ	ENST00000343067; ENSP00000345259; ENSG00000159023 ENST00000347529; ENSP00000290100; ENSG00000159023 [P11171-5] ENST00000373797; ENSP00000362903; ENSG00000159023 [P11171-7] ENST00000373798; ENSP00000362904; ENSG00000159023 ENST00000373800; ENSP00000362906; ENSG00000159023 [P11171-4]
GeneIDⁱ	2035
KEGGⁱ	hsa:2035
MANE-Selectⁱ	ENST00000343067.9; ENSP00000345259.4; NM_001376013.1; NP_001362942.1
UCSCⁱ	uc001brg.3, human [P11171-1]

Organism-specific databases

CTDⁱ	2035
DisGeNETⁱ	2035
GeneCardsⁱ	EPB41
HGNCⁱ	HGNC:3377, EPB41
HPAⁱ	ENSG00000159023, Tissue enhanced (retina)
MalaCardsⁱ	EPB41
MIMⁱ	130500, gene 611804, phenotype
neXtProtⁱ	NX_P11171
OpenTargetsⁱ	ENSG00000159023
Orphanetⁱ	288, Hereditary elliptocytosis
PharmGKBⁱ	PA27810
VEuPathDBⁱ	HostDB:ENSG00000159023
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3527, Eukaryota
GeneTreeⁱ	ENSGT00940000157833
HOGENOMⁱ	CLU_003623_0_1_1
InParanoidⁱ	P11171
OMAⁱ	EHHTFFX
OrthoDBⁱ	1011028at2759
PhylomeDBⁱ	P11171
TreeFamⁱ	TF351626

Enzyme and pathway databases

PathwayCommonsⁱ	P11171
Reactomeⁱ	R-HSA-6794361, Neurexins and neuroligins
SignaLinkⁱ	P11171
SIGNORⁱ	P11171

Miscellaneous databases

BioGRID-ORCSⁱ	2035, 10 hits in 1052 CRISPR screens
ChiTaRSⁱ	EPB41, human
EvolutionaryTraceⁱ	P11171
GeneWikiⁱ	EPB41
GenomeRNAiⁱ	2035
Pharosⁱ	P11171, Tbio
Protein Ontology More...PROⁱ	PR:P11171
RNActⁱ	P11171, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000159023, Expressed in trabecular bone tissue and 224 other tissues
ExpressionAtlasⁱ	P11171, baseline and differential
Genevisibleⁱ	P11171, HS

Family and domain databases

CDDⁱ	cd14473, FERM_B-lobe, 1 hit
DisProtⁱ	DP00678
Gene3Dⁱ	1.20.80.10, 1 hit 2.30.29.30, 1 hit
InterProⁱ	View protein in InterPro IPR008379, Band_4.1_C IPR019749, Band_41_domain IPR021187, Band_41_protein_chordates IPR000798, Ez/rad/moesin-like IPR014847, FERM-adjacent IPR014352, FERM/acyl-CoA-bd_prot_sf IPR035963, FERM_2 IPR019748, FERM_central IPR019747, FERM_CS IPR000299, FERM_domain IPR018979, FERM_N IPR018980, FERM_PH-like_C IPR011993, PH-like_dom_sf IPR007477, SAB_dom IPR029071, Ubiquitin-like_domsf
PANTHERⁱ	PTHR23280:SF12, PTHR23280:SF12, 2 hits
Pfamⁱ	View protein in Pfam PF05902, 4_1_CTD, 1 hit PF08736, FA, 1 hit PF09380, FERM_C, 1 hit PF00373, FERM_M, 1 hit PF09379, FERM_N, 1 hit PF04382, SAB, 1 hit
PRINTSⁱ	PR00935, BAND41 PR00661, ERMFAMILY
SMARTⁱ	View protein in SMART SM00295, B41, 1 hit SM01195, FA, 1 hit SM01196, FERM_C, 1 hit
SUPFAMⁱ	SSF47031, SSF47031, 1 hit SSF54236, SSF54236, 1 hit
PROSITEⁱ	View protein in PROSITE PS00660, FERM_1, 1 hit PS00661, FERM_2, 1 hit PS50057, FERM_3, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	EPB41_HUMAN
Accessionⁱ	P11171Primary (citable) accession number: P11171 Secondary accession number(s): B1ALH8 Q9Y579
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
	Last sequence update:	March 7, 2006
	Last modified:	February 23, 2022
	This is version 234 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Direct protein sequencing, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

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UniProtKB - P11171 (EPB41_HUMAN)

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Protein 4.1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Nucleus

Other locations

Cytoskeleton

Cytosol

Extracellular region or secreted

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Miscellaneous databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Isoform 2 [P11171-2]

Isoform 7 [P11171-7]

GO - Molecular functioni

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ