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Protein

Protein 4.1

Gene

EPB41

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • 1-phosphatidylinositol binding Source: UniProtKB
  • actin binding Source: UniProtKB-KW
  • calmodulin binding Source: UniProtKB-KW
  • phosphoprotein binding Source: CAFA
  • protein C-terminus binding Source: CAFA
  • protein N-terminus binding Source: CAFA
  • spectrin binding Source: BHF-UCL
  • structural constituent of cytoskeleton Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Calmodulin-binding
Biological processCell cycle, Cell division, Mitosis, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-6794361 Neurexins and neuroligins

SIGNOR Signaling Network Open Resource

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SIGNORi
P11171

Protein family/group databases

Transport Classification Database

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TCDBi
8.A.25.1.2 the ezrin/radixin/moesin (ezrin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein 4.1
Short name:
P4.1
Alternative name(s):
4.1R
Band 4.1
EPB4.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EPB41
Synonyms:E41P
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000159023.18

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3377 EPB41

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
130500 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P11171

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Elliptocytosis 1 (EL1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA Rhesus-linked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape.
See also OMIM:611804

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi60T → A: Loss of CDK1-mediated phosphorylation. Abolishes targeting onto the mitotic spindle; when associated with A-712. 1 Publication1
Mutagenesisi712S → A: Loss of CDK1-mediated phosphorylation. Abolishes targeting onto the mitotic spindle; when associated with A-60. 1 Publication1

Keywords - Diseasei

Elliptocytosis, Hereditary hemolytic anemia, Pyropoikilocytosis

Organism-specific databases

DisGeNET

More...
DisGeNETi
2035

MalaCards human disease database

More...
MalaCardsi
EPB41
MIMi611804 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000159023

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
288 Hereditary elliptocytosis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27810

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
EPB41

Domain mapping of disease mutations (DMDM)

More...
DMDMi
90101808

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002193901 – 864Protein 4.1Add BLAST864

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei14PhosphoserineCombined sources1
Modified residuei60Phosphothreonine; by CDK1Combined sources1 Publication1
Modified residuei84PhosphoserineCombined sources1
Modified residuei85PhosphoserineCombined sources1
Modified residuei95PhosphoserineCombined sources1
Modified residuei104PhosphoserineCombined sources1
Modified residuei121PhosphoserineBy similarity1
Modified residuei149PhosphoserineCombined sources1
Modified residuei151PhosphoserineCombined sources1
Modified residuei152PhosphoserineCombined sources1
Modified residuei188PhosphoserineCombined sources1
Modified residuei191PhosphoserineCombined sources1
Modified residuei222PhosphotyrosineBy similarity1
Modified residuei378PhosphothreonineCombined sources1
Modified residuei521PhosphoserineCombined sources1
Modified residuei540PhosphoserineCombined sources1 Publication1
Modified residuei542PhosphoserineCombined sources1
Modified residuei555PhosphoserineCombined sources1
Modified residuei660Phosphotyrosine; by EGFRCombined sources1 Publication1
Modified residuei664PhosphoserineBy similarity1
Modified residuei674PhosphoserineCombined sources1
Modified residuei684PhosphoserineCombined sources1
Modified residuei709PhosphoserineCombined sources1 Publication1
Modified residuei712Phosphoserine; by CDK1Combined sources1 Publication1
Modified residuei736PhosphothreonineCombined sources1
Modified residuei859PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated at multiple sites by different protein kinases and each phosphorylation event selectively modulates the protein's functions.
Phosphorylation on Tyr-660 reduces the ability of 4.1 to promote the assembly of the spectrin/actin/4.1 ternary complex.1 Publication
O-glycosylated; contains N-acetylglucosamine side chains in the C-terminal domain.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P11171

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P11171

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P11171

PeptideAtlas

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PeptideAtlasi
P11171

PRoteomics IDEntifications database

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PRIDEi
P11171

ProteomicsDB human proteome resource

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ProteomicsDBi
52706
52707 [P11171-2]
52708 [P11171-3]
52709 [P11171-4]
52710 [P11171-5]
52711 [P11171-6]
52712 [P11171-7]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
515

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P11171

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P11171

UniCarbKB; an annotated and curated database of glycan structures

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UniCarbKBi
P11171

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P11171

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000159023 Expressed in 209 organ(s), highest expression level in trabecular bone tissue

CleanEx database of gene expression profiles

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CleanExi
HS_EPB41

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P11171 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P11171 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA028076
HPA028412
HPA028414

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds with a high affinity to glycophorin and with lower affinity to band III protein. Associates with the nuclear mitotic apparatus. Interacts with calmodulin (PubMed:10692436). Interacts with CENPJ (PubMed:11003675). Interacts with DLG1 (PubMed:7937897). Also found to associate with contractile apparatus and tight junctions. Interacts with NUMA1; this interaction is negatively regulated by CDK1 during metaphase and promotes anaphase-specific localization of NUMA1 in symmetrically dividing cells (PubMed:23870127).4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
108349, 37 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P11171

Database of interacting proteins

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DIPi
DIP-17032N

Protein interaction database and analysis system

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IntActi
P11171, 12 interactors

Molecular INTeraction database

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MINTi
P11171

STRING: functional protein association networks

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STRINGi
9606.ENSP00000345259

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1864
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Database of protein disorder

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DisProti
DP00678

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P11171

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P11171

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P11171

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini210 – 491FERMPROSITE-ProRule annotationAdd BLAST282

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni494 – 614HydrophilicAdd BLAST121
Regioni615 – 713Spectrin--actin-bindingAdd BLAST99
Regioni714 – 864C-terminal (CTD)Add BLAST151

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IU7N Eukaryota
ENOG410XS0M LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157833

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG007777

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P11171

KEGG Orthology (KO)

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KOi
K06107

Identification of Orthologs from Complete Genome Data

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OMAi
EPTEVWK

Database of Orthologous Groups

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OrthoDBi
EOG091G00IL

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P11171

TreeFam database of animal gene trees

More...
TreeFami
TF351626

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14473 FERM_B-lobe, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.80.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR008379 Band_4.1_C
IPR019749 Band_41_domain
IPR021187 Band_41_protein_chordates
IPR000798 Ez/rad/moesin-like
IPR014847 FERM-adjacent
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR019747 FERM_CS
IPR000299 FERM_domain
IPR018979 FERM_N
IPR018980 FERM_PH-like_C
IPR011993 PH-like_dom_sf
IPR007477 SAB_dom
IPR029071 Ubiquitin-like_domsf

The PANTHER Classification System

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PANTHERi
PTHR23280:SF12 PTHR23280:SF12, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05902 4_1_CTD, 1 hit
PF08736 FA, 1 hit
PF09380 FERM_C, 1 hit
PF00373 FERM_M, 1 hit
PF09379 FERM_N, 1 hit
PF04382 SAB, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00935 BAND41
PR00661 ERMFAMILY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00295 B41, 1 hit
SM01195 FA, 1 hit
SM01196 FERM_C, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47031 SSF47031, 1 hit
SSF54236 SSF54236, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00660 FERM_1, 1 hit
PS00661 FERM_2, 1 hit
PS50057 FERM_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 19 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P11171-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTTEKSLVTE AENSQHQQKE EGEEAINSGQ QEPQQEESCQ TAAEGDNWCE
60 70 80 90 100
QKLKASNGDT PTHEDLTKNK ERTSESRGLS RLFSSFLKRP KSQVSEEEGK
110 120 130 140 150
EVESDKEKGE GGQKEIEFGT SLDEEIILKA PIAAPEPELK TDPSLDLHSL
160 170 180 190 200
SSAETQPAQE ELREDPDFEI KEGEGLEECS KIEVKEESPQ SKAETELKAS
210 220 230 240 250
QKPIRKHRNM HCKVSLLDDT VYECVVEKHA KGQDLLKRVC EHLNLLEEDY
260 270 280 290 300
FGLAIWDNAT SKTWLDSAKE IKKQVRGVPW NFTFNVKFYP PDPAQLTEDI
310 320 330 340 350
TRYYLCLQLR QDIVAGRLPC SFATLALLGS YTIQSELGDY DPELHGVDYV
360 370 380 390 400
SDFKLAPNQT KELEEKVMEL HKSYRSMTPA QADLEFLENA KKLSMYGVDL
410 420 430 440 450
HKAKDLEGVD IILGVCSSGL LVYKDKLRIN RFPWPKVLKI SYKRSSFFIK
460 470 480 490 500
IRPGEQEQYE STIGFKLPSY RAAKKLWKVC VEHHTFFRLT STDTIPKSKF
510 520 530 540 550
LALGSKFRYS GRTQAQTRQA SALIDRPAPH FERTASKRAS RSLDGAAAVD
560 570 580 590 600
SADRSPRPTS APAITQGQVA EGGVLDASAK KTVVPKAQKE TVKAEVKKED
610 620 630 640 650
EPPEQAEPEP TEAWKVEKTH IEVTVPTSNG DQTQKLAEKT EDLIRMRKKK
660 670 680 690 700
RERLDGENIY IRHSNLMLED LDKSQEEIKK HHASISELKK NFMESVPEPR
710 720 730 740 750
PSEWDKRLST HSPFRTLNIN GQIPTGEGPP LVKTQTVTIS DNANAVKSEI
760 770 780 790 800
PTKDVPIVHT ETKTITYEAA QTDDNSGDLD PGVLLTAQTI TSETPSSTTT
810 820 830 840 850
TQITKTVKGG ISETRIEKRI VITGDADIDH DQVLVQAIKE AKEQHPDMSV
860
TKVVVHQETE IADE
Length:864
Mass (Da):97,017
Last modified:March 7, 2006 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB466E7A9D7FBF12B
GO
Isoform 2 (identifier: P11171-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     616-648: Missing.

Show »
Length:831
Mass (Da):93,239
Checksum:iE09038E1654F9248
GO
Isoform 3 (identifier: P11171-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-209: Missing.
     635-648: Missing.

Show »
Length:641
Mass (Da):71,955
Checksum:i0350A4E7EF6E8AE8
GO
Isoform 4 (identifier: P11171-4) [UniParc]FASTAAdd to basket
Also known as: Erythroid

The sequence of this isoform differs from the canonical sequence as follows:
     1-209: Missing.
     616-648: Missing.
     772-805: Missing.

Show »
Length:588
Mass (Da):66,399
Checksum:iD14399077034CFD5
GO
Isoform 5 (identifier: P11171-5) [UniParc]FASTAAdd to basket
Also known as: Non-erythroid A

The sequence of this isoform differs from the canonical sequence as follows:
     228-262: Missing.
     616-648: Missing.
     649-669: Missing.

Show »
Length:775
Mass (Da):86,603
Checksum:i4A2D98E32CF8552C
GO
Isoform 6 (identifier: P11171-6) [UniParc]FASTAAdd to basket
Also known as: Non-erythroid B

The sequence of this isoform differs from the canonical sequence as follows:
     1-209: Missing.
     228-262: Missing.
     616-648: Missing.
     649-669: Missing.

Show »
Length:566
Mass (Da):63,255
Checksum:i288A47844D5CCE62
GO
Isoform 7 (identifier: P11171-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     635-648: Missing.
     729-734: PPLVKT → VSTLST
     735-864: Missing.

Show »
Length:720
Mass (Da):81,235
Checksum:iAE02E72F2EB18335
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 19 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q4VB86Q4VB86_HUMAN
EPB41 protein
EPB41
622Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GWG0A0A1B0GWG0_HUMAN
Protein 4.1
EPB41
483Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y7N0A0A2R8Y7N0_HUMAN
Protein 4.1
EPB41
565Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YCW8A0A2R8YCW8_HUMAN
Protein 4.1
EPB41
748Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y7Y3A0A2R8Y7Y3_HUMAN
Protein 4.1
EPB41
601Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2U3TZH6A0A2U3TZH6_HUMAN
Protein 4.1
EPB41
841Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YD30A0A2R8YD30_HUMAN
Erythrocyte membrane protein band 4...
EPB41 hCG_23375
655Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y6D0A0A2R8Y6D0_HUMAN
Protein 4.1
EPB41
542Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y5Z6A0A2R8Y5Z6_HUMAN
Protein 4.1
EPB41
787Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y5G2A0A2R8Y5G2_HUMAN
Protein 4.1
EPB41
782Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti51Q → H in AAD42222 (Ref. 5) Curated1
Sequence conflicti76S → N in AAD42222 (Ref. 5) Curated1
Sequence conflicti168F → S in AAD42223 (Ref. 9) Curated1
Sequence conflicti259A → T in AAD42222 (Ref. 5) Curated1
Sequence conflicti665N → S in AAD42222 (Ref. 5) Curated1
Sequence conflicti669E → K no nucleotide entry (PubMed:3194408).Curated1
Sequence conflicti679K → E in AAD42222 (Ref. 5) Curated1
Sequence conflicti802Q → K no nucleotide entry (PubMed:3223413).Curated1
Sequence conflicti802Q → K in AAA35793 (PubMed:3375238).Curated1
Sequence conflicti802Q → K in AAA35794 (PubMed:3375238).Curated1
Sequence conflicti852K → L no nucleotide entry (PubMed:3194408).Curated1
Sequence conflicti863D → E no nucleotide entry (PubMed:3194408).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_009122214V → I1 PublicationCorresponds to variant dbSNP:rs111642750Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0004681 – 209Missing in isoform 3, isoform 4 and isoform 6. 4 PublicationsAdd BLAST209
Alternative sequenceiVSP_000469228 – 262Missing in isoform 5 and isoform 6. 2 PublicationsAdd BLAST35
Alternative sequenceiVSP_000470616 – 648Missing in isoform 2, isoform 4, isoform 5 and isoform 6. 3 PublicationsAdd BLAST33
Alternative sequenceiVSP_000471635 – 648Missing in isoform 3 and isoform 7. 2 PublicationsAdd BLAST14
Alternative sequenceiVSP_000472649 – 669Missing in isoform 5 and isoform 6. 2 PublicationsAdd BLAST21
Alternative sequenceiVSP_012872729 – 734PPLVKT → VSTLST in isoform 7. 1 Publication6
Alternative sequenceiVSP_012873735 – 864Missing in isoform 7. 1 PublicationAdd BLAST130
Alternative sequenceiVSP_000473772 – 805Missing in isoform 4. 1 PublicationAdd BLAST34

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M14993 mRNA Translation: AAA35795.1
J03796 mRNA Translation: AAA35793.1
J03796 mRNA Translation: AAA35794.1
M61733 mRNA Translation: AAA35797.1
AF156225 mRNA Translation: AAD42222.1
AL138785 Genomic DNA No translation available.
AL357500 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07663.1
CH471059 Genomic DNA Translation: EAX07665.1
CH471059 Genomic DNA Translation: EAX07667.1
CH471059 Genomic DNA Translation: EAX07668.1
BC039079 mRNA Translation: AAH39079.1
AF156226 Genomic DNA Translation: AAD42223.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS330.1 [P11171-5]
CCDS331.1 [P11171-4]
CCDS332.1 [P11171-3]
CCDS53288.1 [P11171-1]
CCDS53289.1 [P11171-7]

Protein sequence database of the Protein Information Resource

More...
PIRi
A39810 MMHUE4

NCBI Reference Sequences

More...
RefSeqi
NP_001159477.1, NM_001166005.1 [P11171-1]
NP_001159478.1, NM_001166006.1 [P11171-7]
NP_004428.1, NM_004437.3 [P11171-4]
NP_976217.1, NM_203342.2 [P11171-3]
XP_005245818.1, XM_005245761.1 [P11171-1]
XP_005245821.1, XM_005245764.1 [P11171-2]
XP_016856078.1, XM_017000589.1 [P11171-5]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.175437
Hs.708933
Hs.712722

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000343067; ENSP00000345259; ENSG00000159023 [P11171-1]
ENST00000347529; ENSP00000290100; ENSG00000159023 [P11171-5]
ENST00000373797; ENSP00000362903; ENSG00000159023 [P11171-7]
ENST00000373798; ENSP00000362904; ENSG00000159023 [P11171-1]
ENST00000373800; ENSP00000362906; ENSG00000159023 [P11171-4]
ENST00000642260; ENSP00000495565; ENSG00000159023 [P11171-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2035

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2035

UCSC genome browser

More...
UCSCi
uc001brg.3 human [P11171-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14993 mRNA Translation: AAA35795.1
J03796 mRNA Translation: AAA35793.1
J03796 mRNA Translation: AAA35794.1
M61733 mRNA Translation: AAA35797.1
AF156225 mRNA Translation: AAD42222.1
AL138785 Genomic DNA No translation available.
AL357500 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07663.1
CH471059 Genomic DNA Translation: EAX07665.1
CH471059 Genomic DNA Translation: EAX07667.1
CH471059 Genomic DNA Translation: EAX07668.1
BC039079 mRNA Translation: AAH39079.1
AF156226 Genomic DNA Translation: AAD42223.1
CCDSiCCDS330.1 [P11171-5]
CCDS331.1 [P11171-4]
CCDS332.1 [P11171-3]
CCDS53288.1 [P11171-1]
CCDS53289.1 [P11171-7]
PIRiA39810 MMHUE4
RefSeqiNP_001159477.1, NM_001166005.1 [P11171-1]
NP_001159478.1, NM_001166006.1 [P11171-7]
NP_004428.1, NM_004437.3 [P11171-4]
NP_976217.1, NM_203342.2 [P11171-3]
XP_005245818.1, XM_005245761.1 [P11171-1]
XP_005245821.1, XM_005245764.1 [P11171-2]
XP_016856078.1, XM_017000589.1 [P11171-5]
UniGeneiHs.175437
Hs.708933
Hs.712722

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GG3X-ray2.80A/B/C210-488[»]
2RQ1NMR-A292-396[»]
3QIJX-ray1.80A/B211-488[»]
DisProtiDP00678
ProteinModelPortaliP11171
SMRiP11171
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108349, 37 interactors
CORUMiP11171
DIPiDIP-17032N
IntActiP11171, 12 interactors
MINTiP11171
STRINGi9606.ENSP00000345259

Protein family/group databases

TCDBi8.A.25.1.2 the ezrin/radixin/moesin (ezrin) family

PTM databases

GlyConnecti515
iPTMnetiP11171
PhosphoSitePlusiP11171
UniCarbKBiP11171

Polymorphism and mutation databases

BioMutaiEPB41
DMDMi90101808

Proteomic databases

EPDiP11171
MaxQBiP11171
PaxDbiP11171
PeptideAtlasiP11171
PRIDEiP11171
ProteomicsDBi52706
52707 [P11171-2]
52708 [P11171-3]
52709 [P11171-4]
52710 [P11171-5]
52711 [P11171-6]
52712 [P11171-7]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
2035
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343067; ENSP00000345259; ENSG00000159023 [P11171-1]
ENST00000347529; ENSP00000290100; ENSG00000159023 [P11171-5]
ENST00000373797; ENSP00000362903; ENSG00000159023 [P11171-7]
ENST00000373798; ENSP00000362904; ENSG00000159023 [P11171-1]
ENST00000373800; ENSP00000362906; ENSG00000159023 [P11171-4]
ENST00000642260; ENSP00000495565; ENSG00000159023 [P11171-3]
GeneIDi2035
KEGGihsa:2035
UCSCiuc001brg.3 human [P11171-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2035
DisGeNETi2035
EuPathDBiHostDB:ENSG00000159023.18

GeneCards: human genes, protein and diseases

More...
GeneCardsi
EPB41
HGNCiHGNC:3377 EPB41
HPAiHPA028076
HPA028412
HPA028414
MalaCardsiEPB41
MIMi130500 gene
611804 phenotype
neXtProtiNX_P11171
OpenTargetsiENSG00000159023
Orphaneti288 Hereditary elliptocytosis
PharmGKBiPA27810

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IU7N Eukaryota
ENOG410XS0M LUCA
GeneTreeiENSGT00940000157833
HOVERGENiHBG007777
InParanoidiP11171
KOiK06107
OMAiEPTEVWK
OrthoDBiEOG091G00IL
PhylomeDBiP11171
TreeFamiTF351626

Enzyme and pathway databases

ReactomeiR-HSA-6794361 Neurexins and neuroligins
SIGNORiP11171

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
EPB41 human
EvolutionaryTraceiP11171

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
EPB41

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
2035
PMAP-CutDBiP11171

Protein Ontology

More...
PROi
PR:P11171

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000159023 Expressed in 209 organ(s), highest expression level in trabecular bone tissue
CleanExiHS_EPB41
ExpressionAtlasiP11171 baseline and differential
GenevisibleiP11171 HS

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
Gene3Di1.20.80.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR008379 Band_4.1_C
IPR019749 Band_41_domain
IPR021187 Band_41_protein_chordates
IPR000798 Ez/rad/moesin-like
IPR014847 FERM-adjacent
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR019747 FERM_CS
IPR000299 FERM_domain
IPR018979 FERM_N
IPR018980 FERM_PH-like_C
IPR011993 PH-like_dom_sf
IPR007477 SAB_dom
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR23280:SF12 PTHR23280:SF12, 2 hits
PfamiView protein in Pfam
PF05902 4_1_CTD, 1 hit
PF08736 FA, 1 hit
PF09380 FERM_C, 1 hit
PF00373 FERM_M, 1 hit
PF09379 FERM_N, 1 hit
PF04382 SAB, 1 hit
PRINTSiPR00935 BAND41
PR00661 ERMFAMILY
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM01195 FA, 1 hit
SM01196 FERM_C, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS00660 FERM_1, 1 hit
PS00661 FERM_2, 1 hit
PS50057 FERM_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry namei41_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P11171
Secondary accession number(s): B1ALH8
, B1ALH9, D3DPM9, D3DPN0, P11176, Q14245, Q5TB35, Q5VXN8, Q8IXV9, Q9Y578, Q9Y579
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: March 7, 2006
Last modified: December 5, 2018
This is version 214 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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