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Protein

Solute carrier family 2, facilitated glucose transporter member 3

Gene

SLC2A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane (PubMed:9477959, PubMed:26176916). Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate (PubMed:9477959, PubMed:26176916). Does not mediate fructose transport (PubMed:9477959, PubMed:26176916).2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei315Monosaccharide1 Publication1
Binding sitei378Monosaccharide1 Publication1
Binding sitei386Monosaccharide1 Publication1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processSugar transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-189200 Cellular hexose transport
R-HSA-196836 Vitamin C (ascorbate) metabolism
R-HSA-6798695 Neutrophil degranulation
SIGNORiP11169

Protein family/group databases

TCDBi2.A.1.1.91 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 3
Alternative name(s):
Glucose transporter type 3, brain
Short name:
GLUT-3
Gene namesi
Name:SLC2A3
Synonyms:GLUT3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000059804.15
HGNCiHGNC:11007 SLC2A3
MIMi138170 gene
neXtProtiNX_P11169

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicCurated10
Transmembranei11 – 32Helical; Name=1Sequence analysis1 PublicationAdd BLAST22
Topological domaini33 – 64ExtracellularCuratedAdd BLAST32
Transmembranei65 – 85Helical; Name=2Sequence analysis1 PublicationAdd BLAST21
Topological domaini86 – 90CytoplasmicCurated5
Transmembranei91 – 111Helical; Name=3Sequence analysis1 PublicationAdd BLAST21
Topological domaini112 – 118ExtracellularCurated7
Transmembranei119 – 142Helical; Name=4Sequence analysis1 PublicationAdd BLAST24
Topological domaini143 – 153CytoplasmicCuratedAdd BLAST11
Transmembranei154 – 174Helical; Name=5Sequence analysis1 PublicationAdd BLAST21
Topological domaini175 – 183ExtracellularCurated9
Transmembranei184 – 204Helical; Name=6Sequence analysis1 PublicationAdd BLAST21
Topological domaini205 – 269CytoplasmicCuratedAdd BLAST65
Transmembranei270 – 290Helical; Name=7Sequence analysis1 PublicationAdd BLAST21
Topological domaini291 – 304ExtracellularCuratedAdd BLAST14
Transmembranei305 – 325Helical; Name=8Sequence analysis1 PublicationAdd BLAST21
Topological domaini326 – 331CytoplasmicCurated6
Transmembranei332 – 352Helical; Name=9Sequence analysis1 PublicationAdd BLAST21
Topological domaini353 – 363ExtracellularCuratedAdd BLAST11
Transmembranei364 – 389Helical; Name=10Sequence analysis1 PublicationAdd BLAST26
Topological domaini390 – 399CytoplasmicCurated10
Transmembranei400 – 420Helical; Name=11Sequence analysis1 PublicationAdd BLAST21
Topological domaini421 – 429ExtracellularCurated9
Transmembranei430 – 450Helical; Name=12Sequence analysis1 PublicationAdd BLAST21
Topological domaini451 – 496CytoplasmicCuratedAdd BLAST46

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi277 – 279QLS → HVA: Confers moderate fructose transport activity. 1 Publication3

Organism-specific databases

DisGeNETi6515
MalaCardsiSLC2A3
OpenTargetsiENSG00000059804
Orphaneti399 Huntington disease
PharmGKBiPA35877

Chemistry databases

ChEMBLiCHEMBL5215
DrugBankiDB09502 Fludeoxyglucose F-18

Polymorphism and mutation databases

BioMutaiSLC2A3
DMDMi121760

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000503531 – 496Solute carrier family 2, facilitated glucose transporter member 3Add BLAST496

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi43N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei232PhosphothreonineBy similarity1
Modified residuei475PhosphoserineBy similarity1
Modified residuei485PhosphoserineBy similarity1
Modified residuei492PhosphothreonineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP11169
MaxQBiP11169
PaxDbiP11169
PeptideAtlasiP11169
PRIDEiP11169
ProteomicsDBi52705

PTM databases

iPTMnetiP11169
PhosphoSitePlusiP11169

Expressioni

Tissue specificityi

Highly expressed in brain. Expressed in many tissues.1 Publication

Gene expression databases

BgeeiENSG00000059804 Expressed in 232 organ(s), highest expression level in embryo
CleanExiHS_SLC2A3
ExpressionAtlasiP11169 baseline and differential
GenevisibleiP11169 HS

Organism-specific databases

HPAiCAB002763
HPA006539

Interactioni

Protein-protein interaction databases

BioGridi112406, 6 interactors
IntActiP11169, 8 interactors
MINTiP11169
STRINGi9606.ENSP00000075120

Chemistry databases

BindingDBiP11169

Structurei

Secondary structure

1496
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP11169
SMRiP11169
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni277 – 279Important for selectivity against fructose1 Publication3
Regioni280 – 286Monosaccharide binding1 Publication7

Domaini

Transport is mediated via a series of conformation changes, switching between a conformation where the substrate-binding cavity is accessible from the outside, and a another conformation where it is accessible from the cytoplasm.1 Publication

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0569 Eukaryota
COG0477 LUCA
GeneTreeiENSGT00760000119022
HOGENOMiHOG000202871
HOVERGENiHBG014816
InParanoidiP11169
KOiK08142
OMAiNALFFWA
OrthoDBiEOG091G0A9K
PhylomeDBiP11169
TreeFamiTF313762

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR002945 Glc_transpt_3
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
PRINTSiPR01192 GLUCTRSPORT3
PR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit
PS00217 SUGAR_TRANSPORT_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P11169-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTQKVTPAL IFAITVATIG SFQFGYNTGV INAPEKIIKE FINKTLTDKG
60 70 80 90 100
NAPPSEVLLT SLWSLSVAIF SVGGMIGSFS VGLFVNRFGR RNSMLIVNLL
110 120 130 140 150
AVTGGCFMGL CKVAKSVEML ILGRLVIGLF CGLCTGFVPM YIGEISPTAL
160 170 180 190 200
RGAFGTLNQL GIVVGILVAQ IFGLEFILGS EELWPLLLGF TILPAILQSA
210 220 230 240 250
ALPFCPESPR FLLINRKEEE NAKQILQRLW GTQDVSQDIQ EMKDESARMS
260 270 280 290 300
QEKQVTVLEL FRVSSYRQPI IISIVLQLSQ QLSGINAVFY YSTGIFKDAG
310 320 330 340 350
VQEPIYATIG AGVVNTIFTV VSLFLVERAG RRTLHMIGLG GMAFCSTLMT
360 370 380 390 400
VSLLLKDNYN GMSFVCIGAI LVFVAFFEIG PGPIPWFIVA ELFSQGPRPA
410 420 430 440 450
AMAVAGCSNW TSNFLVGLLF PSAAHYLGAY VFIIFTGFLI TFLAFTFFKV
460 470 480 490
PETRGRTFED ITRAFEGQAH GADRSGKDGV MEMNSIEPAK ETTTNV
Length:496
Mass (Da):53,924
Last modified:July 1, 1989 - v1
Checksum:iF601CD6892F16516
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5GYR5F5GYR5_HUMAN
Solute carrier family 2, facilitate...
SLC2A3
141Annotation score:
F5GYX0F5GYX0_HUMAN
Solute carrier family 2, facilitate...
SLC2A3
48Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05250285V → L. Corresponds to variant dbSNP:rs17728193Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20681 mRNA Translation: AAB61083.1
AF274892
, AF274889, AF274890, AF274891 Genomic DNA Translation: AAF82116.1
CR457413 mRNA Translation: CAG33694.1
AK312386 mRNA Translation: BAG35303.1
CH471116 Genomic DNA Translation: EAW88644.1
CH471116 Genomic DNA Translation: EAW88645.1
BC039196 mRNA Translation: AAH39196.1
AY034634 mRNA Translation: AAK56796.1
CCDSiCCDS8586.1
PIRiA31986
T14798
RefSeqiNP_008862.1, NM_006931.2
UniGeneiHs.419240

Genome annotation databases

EnsembliENST00000075120; ENSP00000075120; ENSG00000059804
GeneIDi6515
KEGGihsa:6515
UCSCiuc001qtr.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20681 mRNA Translation: AAB61083.1
AF274892
, AF274889, AF274890, AF274891 Genomic DNA Translation: AAF82116.1
CR457413 mRNA Translation: CAG33694.1
AK312386 mRNA Translation: BAG35303.1
CH471116 Genomic DNA Translation: EAW88644.1
CH471116 Genomic DNA Translation: EAW88645.1
BC039196 mRNA Translation: AAH39196.1
AY034634 mRNA Translation: AAK56796.1
CCDSiCCDS8586.1
PIRiA31986
T14798
RefSeqiNP_008862.1, NM_006931.2
UniGeneiHs.419240

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4ZW9X-ray1.50A1-496[»]
4ZWBX-ray2.40A1-496[»]
4ZWCX-ray2.60A/B1-496[»]
5C65X-ray2.65A/B1-474[»]
ProteinModelPortaliP11169
SMRiP11169
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112406, 6 interactors
IntActiP11169, 8 interactors
MINTiP11169
STRINGi9606.ENSP00000075120

Chemistry databases

BindingDBiP11169
ChEMBLiCHEMBL5215
DrugBankiDB09502 Fludeoxyglucose F-18

Protein family/group databases

TCDBi2.A.1.1.91 the major facilitator superfamily (mfs)

PTM databases

iPTMnetiP11169
PhosphoSitePlusiP11169

Polymorphism and mutation databases

BioMutaiSLC2A3
DMDMi121760

Proteomic databases

EPDiP11169
MaxQBiP11169
PaxDbiP11169
PeptideAtlasiP11169
PRIDEiP11169
ProteomicsDBi52705

Protocols and materials databases

DNASUi6515
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000075120; ENSP00000075120; ENSG00000059804
GeneIDi6515
KEGGihsa:6515
UCSCiuc001qtr.4 human

Organism-specific databases

CTDi6515
DisGeNETi6515
EuPathDBiHostDB:ENSG00000059804.15
GeneCardsiSLC2A3
HGNCiHGNC:11007 SLC2A3
HPAiCAB002763
HPA006539
MalaCardsiSLC2A3
MIMi138170 gene
neXtProtiNX_P11169
OpenTargetsiENSG00000059804
Orphaneti399 Huntington disease
PharmGKBiPA35877
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0569 Eukaryota
COG0477 LUCA
GeneTreeiENSGT00760000119022
HOGENOMiHOG000202871
HOVERGENiHBG014816
InParanoidiP11169
KOiK08142
OMAiNALFFWA
OrthoDBiEOG091G0A9K
PhylomeDBiP11169
TreeFamiTF313762

Enzyme and pathway databases

ReactomeiR-HSA-189200 Cellular hexose transport
R-HSA-196836 Vitamin C (ascorbate) metabolism
R-HSA-6798695 Neutrophil degranulation
SIGNORiP11169

Miscellaneous databases

ChiTaRSiSLC2A3 human
GenomeRNAii6515
PROiPR:P11169
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000059804 Expressed in 232 organ(s), highest expression level in embryo
CleanExiHS_SLC2A3
ExpressionAtlasiP11169 baseline and differential
GenevisibleiP11169 HS

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR002945 Glc_transpt_3
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
PRINTSiPR01192 GLUCTRSPORT3
PR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit
PS00217 SUGAR_TRANSPORT_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGTR3_HUMAN
AccessioniPrimary (citable) accession number: P11169
Secondary accession number(s): B2R606
, D3DUU6, Q6I9U2, Q9UG15
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 7, 2018
This is version 188 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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