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UniProtKB - P11168 (GTR2_HUMAN)

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Protein

Solute carrier family 2, facilitated glucose transporter member 2

Gene

SLC2A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na+/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei349MonosaccharideBy similarity1
Binding sitei420MonosaccharideBy similarity1

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Biological processSugar transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-189200 Cellular hexose transport
R-HSA-210745 Regulation of gene expression in beta cells
R-HSA-422356 Regulation of insulin secretion
R-HSA-5619098 Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS)
R-HSA-8981373 Intestinal hexose absorption
SIGNORiP11168

Protein family/group databases

TCDBi2.A.1.1.29 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 2
Alternative name(s):
Glucose transporter type 2, liver
Short name:
GLUT-2
Gene namesi
Name:SLC2A2
Synonyms:GLUT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000163581.13
HGNCiHGNC:11006 SLC2A2
MIMi138160 gene
neXtProtiNX_P11168

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicSequence analysis10
Transmembranei11 – 31Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini32 – 98ExtracellularSequence analysisAdd BLAST67
Transmembranei99 – 119Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini120 – 127CytoplasmicSequence analysis8
Transmembranei128 – 148Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini149 – 158ExtracellularSequence analysis10
Transmembranei159 – 179Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini180 – 187CytoplasmicSequence analysis8
Transmembranei188 – 208Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini209 – 217ExtracellularSequence analysis9
Transmembranei218 – 238Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini239 – 303CytoplasmicSequence analysisAdd BLAST65
Transmembranei304 – 324Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini325 – 338ExtracellularSequence analysisAdd BLAST14
Transmembranei339 – 359Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini360 – 368CytoplasmicSequence analysis9
Transmembranei369 – 389Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini390 – 400ExtracellularSequence analysisAdd BLAST11
Transmembranei401 – 421Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini422 – 433CytoplasmicSequence analysisAdd BLAST12
Transmembranei434 – 454Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini455 – 461ExtracellularSequence analysis7
Transmembranei462 – 482Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini483 – 524CytoplasmicSequence analysisAdd BLAST42

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Fanconi-Bickel syndrome (FBS)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionRare, well-defined clinical entity, inherited in an autosomal recessive mode and characterized by hepatorenal glycogen accumulation, proximal renal tubular dysfunction, and impaired utilization of glucose and galactose.
See also OMIM:227810
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_018651389L → P in FBS. 1 PublicationCorresponds to variant dbSNP:rs121909747EnsemblClinVar.1
Natural variantiVAR_018652417P → L in FBS. 1 PublicationCorresponds to variant dbSNP:rs121909744EnsemblClinVar.1
Natural variantiVAR_018653423V → E in FBS. 1 PublicationCorresponds to variant dbSNP:rs28928874EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi6514
MalaCardsiSLC2A2
MIMi227810 phenotype
OpenTargetsiENSG00000163581
Orphaneti2088 Glycogen storage disease due to GLUT2 deficiency
PharmGKBiPA35876

Chemistry databases

ChEMBLiCHEMBL5873
DrugBankiDB09502 Fludeoxyglucose F-18
DB00428 Streptozocin

Polymorphism and mutation databases

BioMutaiSLC2A2
DMDMi121756

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000503461 – 524Solute carrier family 2, facilitated glucose transporter member 2Add BLAST524

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi62N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei523PhosphothreonineCombined sources1

Post-translational modificationi

N-glycosylated; required for stability and retention at the cell surface of pancreatic beta cells.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP11168
PaxDbiP11168
PeptideAtlasiP11168
PRIDEiP11168
ProteomicsDBi52704

PTM databases

iPTMnetiP11168
PhosphoSitePlusiP11168

Expressioni

Tissue specificityi

Liver, insulin-producing beta cell, small intestine and kidney.

Gene expression databases

BgeeiENSG00000163581
CleanExiHS_SLC2A2
ExpressionAtlasiP11168 baseline and differential
GenevisibleiP11168 HS

Organism-specific databases

HPAiCAB010444
HPA028997
HPA028998

Interactioni

Protein-protein interaction databases

BioGridi112405, 7 interactors
IntActiP11168, 1 interactor
STRINGi9606.ENSP00000323568

Chemistry databases

BindingDBiP11168

Structurei

3D structure databases

ProteinModelPortaliP11168
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni314 – 320Monosaccharide bindingBy similarity7

Sequence similaritiesi

Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0569 Eukaryota
COG0477 LUCA
GeneTreeiENSGT00760000119022
HOGENOMiHOG000202871
HOVERGENiHBG014816
InParanoidiP11168
KOiK07593
OMAiFQFGYDI
OrthoDBiEOG091G0A9K
PhylomeDBiP11168
TreeFamiTF313762

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR002440 Glc_transpt_2
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
PRINTSiPR01191 GLUCTRSPORT2
PR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 3 hits
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit
PS00217 SUGAR_TRANSPORT_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P11168-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTEDKVTGTL VFTVITAVLG SFQFGYDIGV INAPQQVIIS HYRHVLGVPL 
        60         70         80         90        100
DDRKAINNYV INSTDELPTI SYSMNPKPTP WAEEETVAAA QLITMLWSLS 
       110        120        130        140        150
VSSFAVGGMT ASFFGGWLGD TLGRIKAMLV ANILSLVGAL LMGFSKLGPS 
       160        170        180        190        200
HILIIAGRSI SGLYCGLISG LVPMYIGEIA PTALRGALGT FHQLAIVTGI 
       210        220        230        240        250
LISQIIGLEF ILGNYDLWHI LLGLSGVRAI LQSLLLFFCP ESPRYLYIKL 
       260        270        280        290        300
DEEVKAKQSL KRLRGYDDVT KDINEMRKER EEASSEQKVS IIQLFTNSSY 
       310        320        330        340        350
RQPILVALML HVAQQFSGIN GIFYYSTSIF QTAGISKPVY ATIGVGAVNM 
       360        370        380        390        400
VFTAVSVFLV EKAGRRSLFL IGMSGMFVCA IFMSVGLVLL NKFSWMSYVS 
       410        420        430        440        450
MIAIFLFVSF FEIGPGPIPW FMVAEFFSQG PRPAALAIAA FSNWTCNFIV 
       460        470        480        490        500
ALCFQYIADF CGPYVFFLFA GVLLAFTLFT FFKVPETKGK SFEEIAAEFQ 
       510        520 
KKSGSAHRPK AAVEMKFLGA TETV
Length:524
Mass (Da):57,490
Last modified:July 1, 1989 - v1
Checksum:iDA600577207EC083
GO
Isoform 2 (identifier: P11168-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-123: MTEDKVTGTL...FGGWLGDTLG → MHLN

Show »
Length:405
Mass (Da):44,702
Checksum:i41F3A2ADC187753A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti183A → S in BAF83535 (PubMed:14702039).Curated1
Sequence conflicti269V → I in BAH12783 (PubMed:14702039).Curated1
Sequence conflicti374S → N in BAF83535 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00716968P → L2 PublicationsCorresponds to variant dbSNP:rs7637863EnsemblClinVar.1
Natural variantiVAR_014718101V → I. Corresponds to variant dbSNP:rs1800572EnsemblClinVar.1
Natural variantiVAR_014719110T → I3 PublicationsCorresponds to variant dbSNP:rs5400EnsemblClinVar.1
Natural variantiVAR_018650197V → I in NIDDM; abolishes transport activity of the transporter expressed in Xenopus oocytes. 2 PublicationsCorresponds to variant dbSNP:rs121909741EnsemblClinVar.1
Natural variantiVAR_018651389L → P in FBS. 1 PublicationCorresponds to variant dbSNP:rs121909747EnsemblClinVar.1
Natural variantiVAR_052501404I → T. Corresponds to variant dbSNP:rs2229608Ensembl.1
Natural variantiVAR_018652417P → L in FBS. 1 PublicationCorresponds to variant dbSNP:rs121909744EnsemblClinVar.1
Natural variantiVAR_018653423V → E in FBS. 1 PublicationCorresponds to variant dbSNP:rs28928874EnsemblClinVar.1
Natural variantiVAR_014720478L → V. Corresponds to variant dbSNP:rs5397EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0548351 – 123MTEDK…GDTLG → MHLN in isoform 2. 1 PublicationAdd BLAST123

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03810 mRNA Translation: AAA59514.1
AK290846 mRNA Translation: BAF83535.1
AK298418 mRNA Translation: BAH12783.1
AK313622 mRNA Translation: BAG36383.1
AC061708 Genomic DNA No translation available.
AC092918 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78499.1
CCDSiCCDS3215.1 [P11168-1]
PIRiA31318
RefSeqiNP_000331.1, NM_000340.1 [P11168-1]
NP_001265587.1, NM_001278658.1 [P11168-2]
NP_001265588.1, NM_001278659.1
UniGeneiHs.167584

Genome annotation databases

EnsembliENST00000314251; ENSP00000323568; ENSG00000163581 [P11168-1]
GeneIDi6514
KEGGihsa:6514
UCSCiuc003fhe.2 human [P11168-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGTR2_HUMAN
AccessioniPrimary (citable) accession number: P11168
Secondary accession number(s): A8K481
, B2R936, B7Z547, F8W8V8, Q9UCW9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: June 20, 2018
This is version 183 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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