UniProtKB - P11168 (GTR2_HUMAN)
Solute carrier family 2, facilitated glucose transporter member 2
SLC2A2
Functioni
Facilitative hexose transporter that mediates the transport of glucose and fructose (PubMed:8027028, PubMed:16186102, PubMed:23396969, PubMed:28083649).
Likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell (PubMed:8027028).
May also participate with the Na+/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney (PubMed:3399500).
Also able to mediate the transport of dehydroascorbate (PubMed:23396969).
5 PublicationsCatalytic activityi
Kineticsi
- KM=3.23 mM for dehydroascorbate1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 193 | D-glucoseBy similarity | 1 | |
Binding sitei | 320 | D-glucoseBy similarity | 1 | |
Binding sitei | 349 | D-glucoseBy similarity | 1 | |
Binding sitei | 412 | D-glucoseBy similarity | 1 | |
Binding sitei | 420 | D-glucoseBy similarity | 1 |
GO - Molecular functioni
- dehydroascorbic acid transmembrane transporter activity Source: UniProtKB
- D-glucose transmembrane transporter activity Source: GO_Central
- fructose transmembrane transporter activity Source: UniProtKB
- glucose transmembrane transporter activity Source: UniProtKB
- hexose transmembrane transporter activity Source: GO_Central
GO - Biological processi
- carbohydrate metabolic process Source: ProtInc
- dehydroascorbic acid transport Source: UniProtKB
- fructose transmembrane transport Source: UniProtKB
- glucose import Source: GO_Central
- glucose transmembrane transport Source: UniProtKB
- monosaccharide transmembrane transport Source: GO_Central
Keywordsi
Biological process | Sugar transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | P11168 |
Reactomei | R-HSA-189200, Cellular hexose transport R-HSA-210745, Regulation of gene expression in beta cells R-HSA-422356, Regulation of insulin secretion R-HSA-5619098, Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS) R-HSA-8981373, Intestinal hexose absorption |
SignaLinki | P11168 |
SIGNORi | P11168 |
Protein family/group databases
TCDBi | 2.A.1.1.29, the major facilitator superfamily (mfs) |
Names & Taxonomyi
Protein namesi | Recommended name: Solute carrier family 2, facilitated glucose transporter member 2CuratedAlternative name(s): Glucose transporter type 2, liver1 Publication Short name: GLUT-21 Publication |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11006, SLC2A2 |
MIMi | 138160, gene |
neXtProti | NX_P11168 |
VEuPathDBi | HostDB:ENSG00000163581 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Plasma Membrane
- apical plasma membrane Source: ARUK-UCL
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: UniProtKB
Other locations
- brush border Source: GO_Central
- cell-cell junction Source: Ensembl
- cytoplasm Source: Ensembl
- membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 10 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 11 – 31 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 32 – 98 | ExtracellularSequence analysisAdd BLAST | 67 | |
Transmembranei | 99 – 119 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 120 – 127 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 128 – 148 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 149 – 158 | ExtracellularSequence analysis | 10 | |
Transmembranei | 159 – 179 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 180 – 187 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 188 – 208 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 209 – 217 | ExtracellularSequence analysis | 9 | |
Transmembranei | 218 – 238 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 239 – 303 | CytoplasmicSequence analysisAdd BLAST | 65 | |
Transmembranei | 304 – 324 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 325 – 338 | ExtracellularSequence analysisAdd BLAST | 14 | |
Transmembranei | 339 – 359 | Helical; Name=8Sequence analysisAdd BLAST | 21 | |
Topological domaini | 360 – 368 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 369 – 389 | Helical; Name=9Sequence analysisAdd BLAST | 21 | |
Topological domaini | 390 – 400 | ExtracellularSequence analysisAdd BLAST | 11 | |
Transmembranei | 401 – 421 | Helical; Name=10Sequence analysisAdd BLAST | 21 | |
Topological domaini | 422 – 433 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 434 – 454 | Helical; Name=11Sequence analysisAdd BLAST | 21 | |
Topological domaini | 455 – 461 | ExtracellularSequence analysis | 7 | |
Transmembranei | 462 – 482 | Helical; Name=12Sequence analysisAdd BLAST | 21 | |
Topological domaini | 483 – 524 | CytoplasmicSequence analysisAdd BLAST | 42 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Involvement in diseasei
Fanconi-Bickel syndrome (FBS)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_018651 | 389 | L → P in FBS. 1 PublicationCorresponds to variant dbSNP:rs121909747EnsemblClinVar. | 1 | |
Natural variantiVAR_018652 | 417 | P → L in FBS. 1 PublicationCorresponds to variant dbSNP:rs121909744EnsemblClinVar. | 1 | |
Natural variantiVAR_018653 | 423 | V → E in FBS. 1 PublicationCorresponds to variant dbSNP:rs28928874EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 322 | I → V: Reduced fructose transport. 2 Publications | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 6514 |
MalaCardsi | SLC2A2 |
MIMi | 227810, phenotype |
OpenTargetsi | ENSG00000163581 |
Orphaneti | 2088, Fanconi-Bickel syndrome |
PharmGKBi | PA35876 |
Miscellaneous databases
Pharosi | P11168, Tchem |
Chemistry databases
ChEMBLi | CHEMBL5873 |
DrugBanki | DB01914, D-glucose DB09341, Dextrose, unspecified form DB09502, Fludeoxyglucose (18F) DB01296, Glucosamine DB09344, Invert sugar DB00428, Streptozocin |
Genetic variation databases
BioMutai | SLC2A2 |
DMDMi | 121756 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000050346 | 1 – 524 | Solute carrier family 2, facilitated glucose transporter member 2Add BLAST | 524 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 62 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 523 | PhosphothreonineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
MassIVEi | P11168 |
MaxQBi | P11168 |
PaxDbi | P11168 |
PeptideAtlasi | P11168 |
PRIDEi | P11168 |
ProteomicsDBi | 30213 52704 [P11168-1] |
PTM databases
GlyGeni | P11168, 2 sites, 1 O-linked glycan (1 site) |
iPTMneti | P11168 |
PhosphoSitePlusi | P11168 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000163581, Expressed in liver and 66 other tissues |
ExpressionAtlasi | P11168, baseline and differential |
Genevisiblei | P11168, HS |
Organism-specific databases
HPAi | ENSG00000163581, Tissue enriched (liver) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 112405, 10 interactors |
IntActi | P11168, 3 interactors |
STRINGi | 9606.ENSP00000323568 |
Chemistry databases
BindingDBi | P11168 |
Miscellaneous databases
RNActi | P11168, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 314 – 315 | D-glucose bindingBy similarity | 2 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0569, Eukaryota |
GeneTreei | ENSGT00940000155708 |
HOGENOMi | CLU_001265_30_5_1 |
InParanoidi | P11168 |
OMAi | PQCIPMN |
OrthoDBi | 430696at2759 |
PhylomeDBi | P11168 |
TreeFami | TF313762 |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR002440, Glc_transpt_2 IPR045263, GLUT IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR003663, Sugar/inositol_transpt IPR005829, Sugar_transporter_CS |
PANTHERi | PTHR23503, PTHR23503, 1 hit |
Pfami | View protein in Pfam PF00083, Sugar_tr, 1 hit |
PRINTSi | PR01191, GLUCTRSPORT2 PR00171, SUGRTRNSPORT |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00879, SP, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00216, SUGAR_TRANSPORT_1, 1 hit PS00217, SUGAR_TRANSPORT_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTEDKVTGTL VFTVITAVLG SFQFGYDIGV INAPQQVIIS HYRHVLGVPL
60 70 80 90 100
DDRKAINNYV INSTDELPTI SYSMNPKPTP WAEEETVAAA QLITMLWSLS
110 120 130 140 150
VSSFAVGGMT ASFFGGWLGD TLGRIKAMLV ANILSLVGAL LMGFSKLGPS
160 170 180 190 200
HILIIAGRSI SGLYCGLISG LVPMYIGEIA PTALRGALGT FHQLAIVTGI
210 220 230 240 250
LISQIIGLEF ILGNYDLWHI LLGLSGVRAI LQSLLLFFCP ESPRYLYIKL
260 270 280 290 300
DEEVKAKQSL KRLRGYDDVT KDINEMRKER EEASSEQKVS IIQLFTNSSY
310 320 330 340 350
RQPILVALML HVAQQFSGIN GIFYYSTSIF QTAGISKPVY ATIGVGAVNM
360 370 380 390 400
VFTAVSVFLV EKAGRRSLFL IGMSGMFVCA IFMSVGLVLL NKFSWMSYVS
410 420 430 440 450
MIAIFLFVSF FEIGPGPIPW FMVAEFFSQG PRPAALAIAA FSNWTCNFIV
460 470 480 490 500
ALCFQYIADF CGPYVFFLFA GVLLAFTLFT FFKVPETKGK SFEEIAAEFQ
510 520
KKSGSAHRPK AAVEMKFLGA TETV
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0C4DH64 | A0A0C4DH64_HUMAN | Solute carrier family 2, facilitate... | SLC2A2 | 135 | Annotation score: | ||
C9J0E8 | C9J0E8_HUMAN | Solute carrier family 2, facilitate... | SLC2A2 | 103 | Annotation score: | ||
F8WBJ2 | F8WBJ2_HUMAN | Solute carrier family 2, facilitate... | SLC2A2 | 89 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 183 | A → S in BAF83535 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 269 | V → I in BAH12783 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 374 | S → N in BAF83535 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_007169 | 68 | P → L2 PublicationsCorresponds to variant dbSNP:rs7637863EnsemblClinVar. | 1 | |
Natural variantiVAR_014718 | 101 | V → I. Corresponds to variant dbSNP:rs1800572EnsemblClinVar. | 1 | |
Natural variantiVAR_014719 | 110 | T → I3 PublicationsCorresponds to variant dbSNP:rs5400EnsemblClinVar. | 1 | |
Natural variantiVAR_018650 | 197 | V → I in NIDDM; abolishes transport activity of the transporter expressed in Xenopus oocytes. 2 PublicationsCorresponds to variant dbSNP:rs121909741EnsemblClinVar. | 1 | |
Natural variantiVAR_018651 | 389 | L → P in FBS. 1 PublicationCorresponds to variant dbSNP:rs121909747EnsemblClinVar. | 1 | |
Natural variantiVAR_052501 | 404 | I → T. Corresponds to variant dbSNP:rs2229608Ensembl. | 1 | |
Natural variantiVAR_018652 | 417 | P → L in FBS. 1 PublicationCorresponds to variant dbSNP:rs121909744EnsemblClinVar. | 1 | |
Natural variantiVAR_018653 | 423 | V → E in FBS. 1 PublicationCorresponds to variant dbSNP:rs28928874EnsemblClinVar. | 1 | |
Natural variantiVAR_014720 | 478 | L → V. Corresponds to variant dbSNP:rs5397EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_054835 | 1 – 123 | MTEDK…GDTLG → MHLN in isoform 2. 1 PublicationAdd BLAST | 123 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03810 mRNA Translation: AAA59514.1 AK290846 mRNA Translation: BAF83535.1 AK298418 mRNA Translation: BAH12783.1 AK313622 mRNA Translation: BAG36383.1 AC061708 Genomic DNA No translation available. AC092918 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW78499.1 |
CCDSi | CCDS3215.1 [P11168-1] |
PIRi | A31318 |
RefSeqi | NP_000331.1, NM_000340.1 [P11168-1] NP_001265587.1, NM_001278658.1 [P11168-2] NP_001265588.1, NM_001278659.1 |
Genome annotation databases
Ensembli | ENST00000314251.8; ENSP00000323568.3; ENSG00000163581.14 |
GeneIDi | 6514 |
KEGGi | hsa:6514 |
MANE-Selecti | ENST00000314251.8; ENSP00000323568.3; NM_000340.2; NP_000331.1 |
UCSCi | uc003fhe.2, human [P11168-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia GLUT2 entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03810 mRNA Translation: AAA59514.1 AK290846 mRNA Translation: BAF83535.1 AK298418 mRNA Translation: BAH12783.1 AK313622 mRNA Translation: BAG36383.1 AC061708 Genomic DNA No translation available. AC092918 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW78499.1 |
CCDSi | CCDS3215.1 [P11168-1] |
PIRi | A31318 |
RefSeqi | NP_000331.1, NM_000340.1 [P11168-1] NP_001265587.1, NM_001278658.1 [P11168-2] NP_001265588.1, NM_001278659.1 |
3D structure databases
AlphaFoldDBi | P11168 |
SMRi | P11168 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 112405, 10 interactors |
IntActi | P11168, 3 interactors |
STRINGi | 9606.ENSP00000323568 |
Chemistry databases
BindingDBi | P11168 |
ChEMBLi | CHEMBL5873 |
DrugBanki | DB01914, D-glucose DB09341, Dextrose, unspecified form DB09502, Fludeoxyglucose (18F) DB01296, Glucosamine DB09344, Invert sugar DB00428, Streptozocin |
Protein family/group databases
TCDBi | 2.A.1.1.29, the major facilitator superfamily (mfs) |
PTM databases
GlyGeni | P11168, 2 sites, 1 O-linked glycan (1 site) |
iPTMneti | P11168 |
PhosphoSitePlusi | P11168 |
Genetic variation databases
BioMutai | SLC2A2 |
DMDMi | 121756 |
Proteomic databases
MassIVEi | P11168 |
MaxQBi | P11168 |
PaxDbi | P11168 |
PeptideAtlasi | P11168 |
PRIDEi | P11168 |
ProteomicsDBi | 30213 52704 [P11168-1] |
Protocols and materials databases
Antibodypediai | 4178, 542 antibodies from 41 providers |
DNASUi | 6514 |
Genome annotation databases
Ensembli | ENST00000314251.8; ENSP00000323568.3; ENSG00000163581.14 |
GeneIDi | 6514 |
KEGGi | hsa:6514 |
MANE-Selecti | ENST00000314251.8; ENSP00000323568.3; NM_000340.2; NP_000331.1 |
UCSCi | uc003fhe.2, human [P11168-1] |
Organism-specific databases
CTDi | 6514 |
DisGeNETi | 6514 |
GeneCardsi | SLC2A2 |
HGNCi | HGNC:11006, SLC2A2 |
HPAi | ENSG00000163581, Tissue enriched (liver) |
MalaCardsi | SLC2A2 |
MIMi | 138160, gene 227810, phenotype |
neXtProti | NX_P11168 |
OpenTargetsi | ENSG00000163581 |
Orphaneti | 2088, Fanconi-Bickel syndrome |
PharmGKBi | PA35876 |
VEuPathDBi | HostDB:ENSG00000163581 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0569, Eukaryota |
GeneTreei | ENSGT00940000155708 |
HOGENOMi | CLU_001265_30_5_1 |
InParanoidi | P11168 |
OMAi | PQCIPMN |
OrthoDBi | 430696at2759 |
PhylomeDBi | P11168 |
TreeFami | TF313762 |
Enzyme and pathway databases
PathwayCommonsi | P11168 |
Reactomei | R-HSA-189200, Cellular hexose transport R-HSA-210745, Regulation of gene expression in beta cells R-HSA-422356, Regulation of insulin secretion R-HSA-5619098, Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS) R-HSA-8981373, Intestinal hexose absorption |
SignaLinki | P11168 |
SIGNORi | P11168 |
Miscellaneous databases
BioGRID-ORCSi | 6514, 10 hits in 1070 CRISPR screens |
GenomeRNAii | 6514 |
Pharosi | P11168, Tchem |
PROi | PR:P11168 |
RNActi | P11168, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000163581, Expressed in liver and 66 other tissues |
ExpressionAtlasi | P11168, baseline and differential |
Genevisiblei | P11168, HS |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR002440, Glc_transpt_2 IPR045263, GLUT IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR003663, Sugar/inositol_transpt IPR005829, Sugar_transporter_CS |
PANTHERi | PTHR23503, PTHR23503, 1 hit |
Pfami | View protein in Pfam PF00083, Sugar_tr, 1 hit |
PRINTSi | PR01191, GLUCTRSPORT2 PR00171, SUGRTRNSPORT |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00879, SP, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00216, SUGAR_TRANSPORT_1, 1 hit PS00217, SUGAR_TRANSPORT_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GTR2_HUMAN | |
Accessioni | P11168Primary (citable) accession number: P11168 Secondary accession number(s): A8K481 Q9UCW9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | July 1, 1989 | |
Last modified: | May 25, 2022 | |
This is version 206 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families