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UniProtKB - P11168 (GTR2_HUMAN)

Entry version 190 (03 Jul 2019)
Sequence version 1 (01 Jul 1989)
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Protein

Solute carrier family 2, facilitated glucose transporter member 2

Gene

SLC2A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Facilitative hexose transporter that mediates the transport of glucose and fructose (PubMed:8027028, PubMed:16186102, PubMed:23396969, PubMed:28083649). Likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell (PubMed:8027028). May also participate with the Na+/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney (PubMed:3399500). Also able to mediate the transport of dehydroascorbate (PubMed:23396969).5 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=3.23 mM for dehydroascorbate1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei349MonosaccharideBy similarity1
    Binding sitei420MonosaccharideBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    GO - Biological processi

    Complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Biological processSugar transport, Transport

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...    Reactomei    		R-HSA-189200 Cellular hexose transport
    R-HSA-210745 Regulation of gene expression in beta cells
    R-HSA-422356 Regulation of insulin secretion
    R-HSA-5619098 Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS)
    R-HSA-8981373 Intestinal hexose absorption

    SIGNOR Signaling Network Open Resource

    More...    SIGNORi    		P11168

    Protein family/group databases

    Transport Classification Database

    More...    TCDBi    		2.A.1.1.29 the major facilitator superfamily (mfs)

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Solute carrier family 2, facilitated glucose transporter member 2Curated
    Alternative name(s):
    Glucose transporter type 2, liver1 Publication
    Short name:
    GLUT-21 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:SLC2A2Imported
    Synonyms:GLUT21 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

    Organism-specific databases

    Human Gene Nomenclature Database

    More...    HGNCi    		HGNC:11006 SLC2A2

    Online Mendelian Inheritance in Man (OMIM)

    More...    MIMi    		138160 gene

    neXtProt; the human protein knowledge platform

    More...    neXtProti    		NX_P11168

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 10CytoplasmicSequence analysis10
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei11 – 31Helical; Name=1Sequence analysisAdd BLAST21
    Topological domaini32 – 98ExtracellularSequence analysisAdd BLAST67
    Transmembranei99 – 119Helical; Name=2Sequence analysisAdd BLAST21
    Topological domaini120 – 127CytoplasmicSequence analysis8
    Transmembranei128 – 148Helical; Name=3Sequence analysisAdd BLAST21
    Topological domaini149 – 158ExtracellularSequence analysis10
    Transmembranei159 – 179Helical; Name=4Sequence analysisAdd BLAST21
    Topological domaini180 – 187CytoplasmicSequence analysis8
    Transmembranei188 – 208Helical; Name=5Sequence analysisAdd BLAST21
    Topological domaini209 – 217ExtracellularSequence analysis9
    Transmembranei218 – 238Helical; Name=6Sequence analysisAdd BLAST21
    Topological domaini239 – 303CytoplasmicSequence analysisAdd BLAST65
    Transmembranei304 – 324Helical; Name=7Sequence analysisAdd BLAST21
    Topological domaini325 – 338ExtracellularSequence analysisAdd BLAST14
    Transmembranei339 – 359Helical; Name=8Sequence analysisAdd BLAST21
    Topological domaini360 – 368CytoplasmicSequence analysis9
    Transmembranei369 – 389Helical; Name=9Sequence analysisAdd BLAST21
    Topological domaini390 – 400ExtracellularSequence analysisAdd BLAST11
    Transmembranei401 – 421Helical; Name=10Sequence analysisAdd BLAST21
    Topological domaini422 – 433CytoplasmicSequence analysisAdd BLAST12
    Transmembranei434 – 454Helical; Name=11Sequence analysisAdd BLAST21
    Topological domaini455 – 461ExtracellularSequence analysis7
    Transmembranei462 – 482Helical; Name=12Sequence analysisAdd BLAST21
    Topological domaini483 – 524CytoplasmicSequence analysisAdd BLAST42

    Keywords - Cellular componenti

    Cell membrane, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

    Fanconi-Bickel syndrome (FBS)2 Publications
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionRare, well-defined clinical entity, inherited in an autosomal recessive mode and characterized by hepatorenal glycogen accumulation, proximal renal tubular dysfunction, and impaired utilization of glucose and galactose.
    Related information in OMIM
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_018651389L → P in FBS. 1 PublicationCorresponds to variant dbSNP:rs121909747EnsemblClinVar.1
    Natural variantiVAR_018652417P → L in FBS. 1 PublicationCorresponds to variant dbSNP:rs121909744EnsemblClinVar.1
    Natural variantiVAR_018653423V → E in FBS. 1 PublicationCorresponds to variant dbSNP:rs28928874EnsemblClinVar.1

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi322I → V: Reduced fructose transport. 2 Publications1

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    DisGeNET

    More...    DisGeNETi    		6514

    MalaCards human disease database

    More...    MalaCardsi    		SLC2A2
    MIMi227810 phenotype

    Open Targets

    More...    OpenTargetsi    		ENSG00000163581

    Orphanet; a database dedicated to information on rare diseases and orphan drugs

    More...    Orphaneti    		2088 Glycogen storage disease due to GLUT2 deficiency

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...    PharmGKBi    		PA35876

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...    ChEMBLi    		CHEMBL5873

    Drug and drug target database

    More...    DrugBanki    		DB09502 Fludeoxyglucose F-18
    DB00428 Streptozocin

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...    BioMutai    		SLC2A2

    Domain mapping of disease mutations (DMDM)

    More...    DMDMi    		121756

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000503461 – 524Solute carrier family 2, facilitated glucose transporter member 2Add BLAST524

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi62N-linked (GlcNAc...) asparagineSequence analysis1
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei523PhosphothreonineCombined sources1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    N-glycosylated; required for stability and retention at the cell surface of pancreatic beta cells.By similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQB - The MaxQuant DataBase

    More...    MaxQBi    		P11168

    PaxDb, a database of protein abundance averages across all three domains of life

    More...    PaxDbi    		P11168

    PeptideAtlas

    More...    PeptideAtlasi    		P11168

    PRoteomics IDEntifications database

    More...    PRIDEi    		P11168

    ProteomicsDB human proteome resource

    More...    ProteomicsDBi    		52704

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...    iPTMneti    		P11168

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...    PhosphoSitePlusi    		P11168

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Liver, insulin-producing beta cell, small intestine and kidney.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...    Bgeei    		ENSG00000163581 Expressed in 46 organ(s), highest expression level in liver

    ExpressionAtlas, Differential and Baseline Expression

    More...    ExpressionAtlasi    		P11168 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...    Genevisiblei    		P11168 HS

    Organism-specific databases

    Human Protein Atlas

    More...    HPAi    		CAB010444
    HPA028997
    HPA028998

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...    BioGridi    		112405, 7 interactors

    Protein interaction database and analysis system

    More...    IntActi    		P11168, 1 interactor

    STRING: functional protein association networks

    More...    STRINGi    		9606.ENSP00000323568

    Chemistry databases

    BindingDB database of measured binding affinities

    More...    BindingDBi    		P11168

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni314 – 320Monosaccharide bindingBy similarity7

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. [View classification]Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...    eggNOGi    		KOG0569 Eukaryota
    COG0477 LUCA

    Ensembl GeneTree

    More...    GeneTreei    		ENSGT00940000155708

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...    HOGENOMi    		HOG000202871

    InParanoid: Eukaryotic Ortholog Groups

    More...    InParanoidi    		P11168

    KEGG Orthology (KO)

    More...    KOi    		K07593

    Identification of Orthologs from Complete Genome Data

    More...    OMAi    		MYWSLSV

    Database of Orthologous Groups

    More...    OrthoDBi    		430696at2759

    Database for complete collections of gene phylogenies

    More...    PhylomeDBi    		P11168

    TreeFam database of animal gene trees

    More...    TreeFami    		TF313762

    Family and domain databases

    Conserved Domains Database

    More...    CDDi    		cd06174 MFS, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR002440 Glc_transpt_2
    IPR020846 MFS_dom
    IPR005828 MFS_sugar_transport-like
    IPR036259 MFS_trans_sf
    IPR003663 Sugar/inositol_transpt
    IPR005829 Sugar_transporter_CS

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF00083 Sugar_tr, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...    PRINTSi    		PR01191 GLUCTRSPORT2
    PR00171 SUGRTRNSPORT

    Superfamily database of structural and functional annotation

    More...    SUPFAMi    		SSF103473 SSF103473, 1 hit

    TIGRFAMs; a protein family database

    More...    TIGRFAMsi    		TIGR00879 SP, 1 hit

    PROSITE; a protein domain and family database

    More...    PROSITEi    		View protein in PROSITE
    PS50850 MFS, 1 hit
    PS00216 SUGAR_TRANSPORT_1, 1 hit
    PS00217 SUGAR_TRANSPORT_2, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: P11168-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MTEDKVTGTL VFTVITAVLG SFQFGYDIGV INAPQQVIIS HYRHVLGVPL 
            60         70         80         90        100
    DDRKAINNYV INSTDELPTI SYSMNPKPTP WAEEETVAAA QLITMLWSLS 
           110        120        130        140        150
    VSSFAVGGMT ASFFGGWLGD TLGRIKAMLV ANILSLVGAL LMGFSKLGPS 
           160        170        180        190        200
    HILIIAGRSI SGLYCGLISG LVPMYIGEIA PTALRGALGT FHQLAIVTGI 
           210        220        230        240        250
    LISQIIGLEF ILGNYDLWHI LLGLSGVRAI LQSLLLFFCP ESPRYLYIKL 
           260        270        280        290        300
    DEEVKAKQSL KRLRGYDDVT KDINEMRKER EEASSEQKVS IIQLFTNSSY 
           310        320        330        340        350
    RQPILVALML HVAQQFSGIN GIFYYSTSIF QTAGISKPVY ATIGVGAVNM 
           360        370        380        390        400
    VFTAVSVFLV EKAGRRSLFL IGMSGMFVCA IFMSVGLVLL NKFSWMSYVS 
           410        420        430        440        450
    MIAIFLFVSF FEIGPGPIPW FMVAEFFSQG PRPAALAIAA FSNWTCNFIV 
           460        470        480        490        500
    ALCFQYIADF CGPYVFFLFA GVLLAFTLFT FFKVPETKGK SFEEIAAEFQ 
           510        520 
    KKSGSAHRPK AAVEMKFLGA TETV
    Length:524
    Mass (Da):57,490
    Last modified:July 1, 1989 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDA600577207EC083
    GO
    Isoform 2 (identifier: P11168-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-123: MTEDKVTGTL...FGGWLGDTLG → MHLN

    Show »
    Length:405
    Mass (Da):44,702
    Checksum:i41F3A2ADC187753A
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    		Gene namesLengthAnnotation
    C9J0E8C9J0E8_HUMAN
    Solute carrier family 2, facilitate...
    SLC2A2
    		103Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A0C4DH64A0A0C4DH64_HUMAN
    Solute carrier family 2, facilitate...
    SLC2A2
    		135Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    F8WBJ2F8WBJ2_HUMAN
    Solute carrier family 2, facilitate...
    SLC2A2
    		89Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti183A → S in BAF83535 (PubMed:14702039).Curated1
    Sequence conflicti269V → I in BAH12783 (PubMed:14702039).Curated1
    Sequence conflicti374S → N in BAF83535 (PubMed:14702039).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_00716968P → L2 PublicationsCorresponds to variant dbSNP:rs7637863EnsemblClinVar.1
    Natural variantiVAR_014718101V → I. Corresponds to variant dbSNP:rs1800572EnsemblClinVar.1
    Natural variantiVAR_014719110T → I3 PublicationsCorresponds to variant dbSNP:rs5400EnsemblClinVar.1
    Natural variantiVAR_018650197V → I in NIDDM; abolishes transport activity of the transporter expressed in Xenopus oocytes. 2 PublicationsCorresponds to variant dbSNP:rs121909741EnsemblClinVar.1
    Natural variantiVAR_018651389L → P in FBS. 1 PublicationCorresponds to variant dbSNP:rs121909747EnsemblClinVar.1
    Natural variantiVAR_052501404I → T. Corresponds to variant dbSNP:rs2229608Ensembl.1
    Natural variantiVAR_018652417P → L in FBS. 1 PublicationCorresponds to variant dbSNP:rs121909744EnsemblClinVar.1
    Natural variantiVAR_018653423V → E in FBS. 1 PublicationCorresponds to variant dbSNP:rs28928874EnsemblClinVar.1
    Natural variantiVAR_014720478L → V. Corresponds to variant dbSNP:rs5397EnsemblClinVar.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0548351 – 123MTEDK…GDTLG → MHLN in isoform 2. 1 PublicationAdd BLAST123

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		J03810 mRNA Translation: AAA59514.1
    AK290846 mRNA Translation: BAF83535.1
    AK298418 mRNA Translation: BAH12783.1
    AK313622 mRNA Translation: BAG36383.1
    AC061708 Genomic DNA No translation available.
    AC092918 Genomic DNA No translation available.
    CH471052 Genomic DNA Translation: EAW78499.1

    The Consensus CDS (CCDS) project

    More...    CCDSi    		CCDS3215.1 [P11168-1]

    Protein sequence database of the Protein Information Resource

    More...    PIRi    		A31318

    NCBI Reference Sequences

    More...    RefSeqi    		NP_000331.1, NM_000340.1 [P11168-1]
    NP_001265587.1, NM_001278658.1 [P11168-2]
    NP_001265588.1, NM_001278659.1

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...    Ensembli    		ENST00000314251; ENSP00000323568; ENSG00000163581 [P11168-1]

    Database of genes from NCBI RefSeq genomes

    More...    GeneIDi    		6514

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...    KEGGi    		hsa:6514

    UCSC genome browser

    More...    UCSCi    		uc003fhe.2 human [P11168-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    <p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

    Wikipedia

    GLUT2 entry

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		J03810 mRNA Translation: AAA59514.1
    AK290846 mRNA Translation: BAF83535.1
    AK298418 mRNA Translation: BAH12783.1
    AK313622 mRNA Translation: BAG36383.1
    AC061708 Genomic DNA No translation available.
    AC092918 Genomic DNA No translation available.
    CH471052 Genomic DNA Translation: EAW78499.1
    CCDSiCCDS3215.1 [P11168-1]
    PIRiA31318
    RefSeqiNP_000331.1, NM_000340.1 [P11168-1]
    NP_001265587.1, NM_001278658.1 [P11168-2]
    NP_001265588.1, NM_001278659.1

    3D structure databases

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    SWISS-MODEL Interactive Workspace

    More...    SWISS-MODEL-Workspacei    		Submit a new modelling project...

    Protein-protein interaction databases

    BioGridi112405, 7 interactors
    IntActiP11168, 1 interactor
    STRINGi9606.ENSP00000323568

    Chemistry databases

    BindingDBiP11168
    ChEMBLiCHEMBL5873
    DrugBankiDB09502 Fludeoxyglucose F-18
    DB00428 Streptozocin

    Protein family/group databases

    TCDBi2.A.1.1.29 the major facilitator superfamily (mfs)

    PTM databases

    iPTMnetiP11168
    PhosphoSitePlusiP11168

    Polymorphism and mutation databases

    BioMutaiSLC2A2
    DMDMi121756

    Proteomic databases

    MaxQBiP11168
    PaxDbiP11168
    PeptideAtlasiP11168
    PRIDEiP11168
    ProteomicsDBi52704

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000314251; ENSP00000323568; ENSG00000163581 [P11168-1]
    GeneIDi6514
    KEGGihsa:6514
    UCSCiuc003fhe.2 human [P11168-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...    CTDi    		6514
    DisGeNETi6514

    GeneCards: human genes, protein and diseases

    More...    GeneCardsi    		SLC2A2
    HGNCiHGNC:11006 SLC2A2
    HPAiCAB010444
    HPA028997
    HPA028998
    MalaCardsiSLC2A2
    MIMi138160 gene
    227810 phenotype
    neXtProtiNX_P11168
    OpenTargetsiENSG00000163581
    Orphaneti2088 Glycogen storage disease due to GLUT2 deficiency
    PharmGKBiPA35876

    GenAtlas: human gene database

    More...    GenAtlasi    		Search...

    Phylogenomic databases

    eggNOGiKOG0569 Eukaryota
    COG0477 LUCA
    GeneTreeiENSGT00940000155708
    HOGENOMiHOG000202871
    InParanoidiP11168
    KOiK07593
    OMAiMYWSLSV
    OrthoDBi430696at2759
    PhylomeDBiP11168
    TreeFamiTF313762

    Enzyme and pathway databases

    ReactomeiR-HSA-189200 Cellular hexose transport
    R-HSA-210745 Regulation of gene expression in beta cells
    R-HSA-422356 Regulation of insulin secretion
    R-HSA-5619098 Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS)
    R-HSA-8981373 Intestinal hexose absorption
    SIGNORiP11168

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...    ChiTaRSi    		SLC2A2 human

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...    GenomeRNAii    		6514

    Protein Ontology

    More...    PROi    		PR:P11168

    The Stanford Online Universal Resource for Clones and ESTs

    More...    SOURCEi    		Search...

    Gene expression databases

    BgeeiENSG00000163581 Expressed in 46 organ(s), highest expression level in liver
    ExpressionAtlasiP11168 baseline and differential
    GenevisibleiP11168 HS

    Family and domain databases

    CDDicd06174 MFS, 1 hit
    InterProiView protein in InterPro
    IPR002440 Glc_transpt_2
    IPR020846 MFS_dom
    IPR005828 MFS_sugar_transport-like
    IPR036259 MFS_trans_sf
    IPR003663 Sugar/inositol_transpt
    IPR005829 Sugar_transporter_CS
    PfamiView protein in Pfam
    PF00083 Sugar_tr, 1 hit
    PRINTSiPR01191 GLUCTRSPORT2
    PR00171 SUGRTRNSPORT
    SUPFAMiSSF103473 SSF103473, 1 hit
    TIGRFAMsiTIGR00879 SP, 1 hit
    PROSITEiView protein in PROSITE
    PS50850 MFS, 1 hit
    PS00216 SUGAR_TRANSPORT_1, 1 hit
    PS00217 SUGAR_TRANSPORT_2, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...    ProtoNeti    		Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGTR2_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P11168
    Secondary accession number(s): A8K481
    , B2R936, B7Z547, F8W8V8, Q9UCW9
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: July 3, 2019
    This is version 190 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
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