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UniProtKB - P11168 (GTR2_HUMAN)

Entry version 204 (29 Sep 2021)
Sequence version 1 (01 Jul 1989)
Previous versions | rss
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Protein

Solute carrier family 2, facilitated glucose transporter member 2

Gene

SLC2A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Facilitative hexose transporter that mediates the transport of glucose and fructose (PubMed:8027028, PubMed:16186102, PubMed:23396969, PubMed:28083649).

Likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell (PubMed:8027028).

May also participate with the Na+/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney (PubMed:3399500).

Also able to mediate the transport of dehydroascorbate (PubMed:23396969).

5 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=3.23 mM for dehydroascorbate1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei349MonosaccharideBy similarity1
Binding sitei420MonosaccharideBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processSugar transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P11168

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-189200, Cellular hexose transport
R-HSA-210745, Regulation of gene expression in beta cells
R-HSA-422356, Regulation of insulin secretion
R-HSA-5619098, Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS)
R-HSA-8981373, Intestinal hexose absorption

SIGNOR Signaling Network Open Resource

More...SIGNORi		P11168

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.1.1.29, the major facilitator superfamily (mfs)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 2Curated
Alternative name(s):
Glucose transporter type 2, liver1 Publication
Short name:
GLUT-21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC2A2Imported
Synonyms:GLUT21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11006, SLC2A2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		138160, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P11168

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000163581

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 10CytoplasmicSequence analysis10
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei11 – 31Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini32 – 98ExtracellularSequence analysisAdd BLAST67
Transmembranei99 – 119Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini120 – 127CytoplasmicSequence analysis8
Transmembranei128 – 148Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini149 – 158ExtracellularSequence analysis10
Transmembranei159 – 179Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini180 – 187CytoplasmicSequence analysis8
Transmembranei188 – 208Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini209 – 217ExtracellularSequence analysis9
Transmembranei218 – 238Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini239 – 303CytoplasmicSequence analysisAdd BLAST65
Transmembranei304 – 324Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini325 – 338ExtracellularSequence analysisAdd BLAST14
Transmembranei339 – 359Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini360 – 368CytoplasmicSequence analysis9
Transmembranei369 – 389Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini390 – 400ExtracellularSequence analysisAdd BLAST11
Transmembranei401 – 421Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini422 – 433CytoplasmicSequence analysisAdd BLAST12
Transmembranei434 – 454Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini455 – 461ExtracellularSequence analysis7
Transmembranei462 – 482Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini483 – 524CytoplasmicSequence analysisAdd BLAST42

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Fanconi-Bickel syndrome (FBS)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionRare, well-defined clinical entity, inherited in an autosomal recessive mode and characterized by hepatorenal glycogen accumulation, proximal renal tubular dysfunction, and impaired utilization of glucose and galactose.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_018651389L → P in FBS. 1 PublicationCorresponds to variant dbSNP:rs121909747EnsemblClinVar.1
Natural variantiVAR_018652417P → L in FBS. 1 PublicationCorresponds to variant dbSNP:rs121909744EnsemblClinVar.1
Natural variantiVAR_018653423V → E in FBS. 1 PublicationCorresponds to variant dbSNP:rs28928874EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi322I → V: Reduced fructose transport. 2 Publications1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		6514

MalaCards human disease database

More...MalaCardsi		SLC2A2
MIMi227810, phenotype

Open Targets

More...OpenTargetsi		ENSG00000163581

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		2088, Fanconi-Bickel syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA35876

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P11168, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL5873

Drug and drug target database

More...DrugBanki		DB01914, D-glucose
DB09341, Dextrose, unspecified form
DB09502, Fludeoxyglucose (18F)
DB09344, Invert sugar
DB00428, Streptozocin

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SLC2A2

Domain mapping of disease mutations (DMDM)

More...DMDMi		121756

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000503461 – 524Solute carrier family 2, facilitated glucose transporter member 2Add BLAST524

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi62N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei523PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated; required for stability and retention at the cell surface of pancreatic beta cells.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P11168

MaxQB - The MaxQuant DataBase

More...MaxQBi		P11168

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P11168

PeptideAtlas

More...PeptideAtlasi		P11168

PRoteomics IDEntifications database

More...PRIDEi		P11168

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		30213
52704 [P11168-1]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P11168, 2 sites, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P11168

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P11168

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Liver, insulin-producing beta cell, small intestine and kidney.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000163581, Expressed in liver and 66 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P11168, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P11168, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000163581, Group enriched (intestine, liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112405, 8 interactors

Protein interaction database and analysis system

More...IntActi		P11168, 3 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000323568

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P11168

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P11168, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni314 – 320Monosaccharide bindingBy similarity7

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0569, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155708

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001265_30_5_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P11168

Identification of Orthologs from Complete Genome Data

More...OMAi		PQCIPMN

Database of Orthologous Groups

More...OrthoDBi		430696at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P11168

TreeFam database of animal gene trees

More...TreeFami		TF313762

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1250.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002440, Glc_transpt_2
IPR020846, MFS_dom
IPR005828, MFS_sugar_transport-like
IPR036259, MFS_trans_sf
IPR003663, Sugar/inositol_transpt
IPR005829, Sugar_transporter_CS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00083, Sugar_tr, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01191, GLUCTRSPORT2
PR00171, SUGRTRNSPORT

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF103473, SSF103473, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00879, SP, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50850, MFS, 1 hit
PS00216, SUGAR_TRANSPORT_1, 1 hit
PS00217, SUGAR_TRANSPORT_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P11168-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTEDKVTGTL VFTVITAVLG SFQFGYDIGV INAPQQVIIS HYRHVLGVPL 
        60         70         80         90        100
DDRKAINNYV INSTDELPTI SYSMNPKPTP WAEEETVAAA QLITMLWSLS 
       110        120        130        140        150
VSSFAVGGMT ASFFGGWLGD TLGRIKAMLV ANILSLVGAL LMGFSKLGPS 
       160        170        180        190        200
HILIIAGRSI SGLYCGLISG LVPMYIGEIA PTALRGALGT FHQLAIVTGI 
       210        220        230        240        250
LISQIIGLEF ILGNYDLWHI LLGLSGVRAI LQSLLLFFCP ESPRYLYIKL 
       260        270        280        290        300
DEEVKAKQSL KRLRGYDDVT KDINEMRKER EEASSEQKVS IIQLFTNSSY 
       310        320        330        340        350
RQPILVALML HVAQQFSGIN GIFYYSTSIF QTAGISKPVY ATIGVGAVNM 
       360        370        380        390        400
VFTAVSVFLV EKAGRRSLFL IGMSGMFVCA IFMSVGLVLL NKFSWMSYVS 
       410        420        430        440        450
MIAIFLFVSF FEIGPGPIPW FMVAEFFSQG PRPAALAIAA FSNWTCNFIV 
       460        470        480        490        500
ALCFQYIADF CGPYVFFLFA GVLLAFTLFT FFKVPETKGK SFEEIAAEFQ 
       510        520 
KKSGSAHRPK AAVEMKFLGA TETV
Length:524
Mass (Da):57,490
Last modified:July 1, 1989 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDA600577207EC083
GO
Isoform 2 (identifier: P11168-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-123: MTEDKVTGTL...FGGWLGDTLG → MHLN

Show »
Length:405
Mass (Da):44,702
Checksum:i41F3A2ADC187753A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DH64A0A0C4DH64_HUMAN
Solute carrier family 2, facilitate...
SLC2A2
135Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J0E8C9J0E8_HUMAN
Solute carrier family 2, facilitate...
SLC2A2
103Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WBJ2F8WBJ2_HUMAN
Solute carrier family 2, facilitate...
SLC2A2
89Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti183A → S in BAF83535 (PubMed:14702039).Curated1
Sequence conflicti269V → I in BAH12783 (PubMed:14702039).Curated1
Sequence conflicti374S → N in BAF83535 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00716968P → L2 PublicationsCorresponds to variant dbSNP:rs7637863EnsemblClinVar.1
Natural variantiVAR_014718101V → I. Corresponds to variant dbSNP:rs1800572EnsemblClinVar.1
Natural variantiVAR_014719110T → I3 PublicationsCorresponds to variant dbSNP:rs5400EnsemblClinVar.1
Natural variantiVAR_018650197V → I in NIDDM; abolishes transport activity of the transporter expressed in Xenopus oocytes. 2 PublicationsCorresponds to variant dbSNP:rs121909741EnsemblClinVar.1
Natural variantiVAR_018651389L → P in FBS. 1 PublicationCorresponds to variant dbSNP:rs121909747EnsemblClinVar.1
Natural variantiVAR_052501404I → T. Corresponds to variant dbSNP:rs2229608Ensembl.1
Natural variantiVAR_018652417P → L in FBS. 1 PublicationCorresponds to variant dbSNP:rs121909744EnsemblClinVar.1
Natural variantiVAR_018653423V → E in FBS. 1 PublicationCorresponds to variant dbSNP:rs28928874EnsemblClinVar.1
Natural variantiVAR_014720478L → V. Corresponds to variant dbSNP:rs5397EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0548351 – 123MTEDK…GDTLG → MHLN in isoform 2. 1 PublicationAdd BLAST123

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
J03810 mRNA Translation: AAA59514.1
AK290846 mRNA Translation: BAF83535.1
AK298418 mRNA Translation: BAH12783.1
AK313622 mRNA Translation: BAG36383.1
AC061708 Genomic DNA No translation available.
AC092918 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78499.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3215.1 [P11168-1]

Protein sequence database of the Protein Information Resource

More...PIRi		A31318

NCBI Reference Sequences

More...RefSeqi		NP_000331.1, NM_000340.1 [P11168-1]
NP_001265587.1, NM_001278658.1 [P11168-2]
NP_001265588.1, NM_001278659.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000314251; ENSP00000323568; ENSG00000163581 [P11168-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6514

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6514

UCSC genome browser

More...UCSCi		uc003fhe.2, human [P11168-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

GLUT2 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03810 mRNA Translation: AAA59514.1
AK290846 mRNA Translation: BAF83535.1
AK298418 mRNA Translation: BAH12783.1
AK313622 mRNA Translation: BAG36383.1
AC061708 Genomic DNA No translation available.
AC092918 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78499.1
CCDSiCCDS3215.1 [P11168-1]
PIRiA31318
RefSeqiNP_000331.1, NM_000340.1 [P11168-1]
NP_001265587.1, NM_001278658.1 [P11168-2]
NP_001265588.1, NM_001278659.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi112405, 8 interactors
IntActiP11168, 3 interactors
STRINGi9606.ENSP00000323568

Chemistry databases

BindingDBiP11168
ChEMBLiCHEMBL5873
DrugBankiDB01914, D-glucose
DB09341, Dextrose, unspecified form
DB09502, Fludeoxyglucose (18F)
DB09344, Invert sugar
DB00428, Streptozocin

Protein family/group databases

TCDBi2.A.1.1.29, the major facilitator superfamily (mfs)

PTM databases

GlyGeniP11168, 2 sites, 1 O-linked glycan (1 site)
iPTMnetiP11168
PhosphoSitePlusiP11168

Genetic variation databases

BioMutaiSLC2A2
DMDMi121756

Proteomic databases

MassIVEiP11168
MaxQBiP11168
PaxDbiP11168
PeptideAtlasiP11168
PRIDEiP11168
ProteomicsDBi30213
52704 [P11168-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		4178, 540 antibodies

The DNASU plasmid repository

More...DNASUi		6514

Genome annotation databases

EnsembliENST00000314251; ENSP00000323568; ENSG00000163581 [P11168-1]
GeneIDi6514
KEGGihsa:6514
UCSCiuc003fhe.2, human [P11168-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6514
DisGeNETi6514

GeneCards: human genes, protein and diseases

More...GeneCardsi		SLC2A2
HGNCiHGNC:11006, SLC2A2
HPAiENSG00000163581, Group enriched (intestine, liver)
MalaCardsiSLC2A2
MIMi138160, gene
227810, phenotype
neXtProtiNX_P11168
OpenTargetsiENSG00000163581
Orphaneti2088, Fanconi-Bickel syndrome
PharmGKBiPA35876
VEuPathDBiHostDB:ENSG00000163581

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0569, Eukaryota
GeneTreeiENSGT00940000155708
HOGENOMiCLU_001265_30_5_1
InParanoidiP11168
OMAiPQCIPMN
OrthoDBi430696at2759
PhylomeDBiP11168
TreeFamiTF313762

Enzyme and pathway databases

PathwayCommonsiP11168
ReactomeiR-HSA-189200, Cellular hexose transport
R-HSA-210745, Regulation of gene expression in beta cells
R-HSA-422356, Regulation of insulin secretion
R-HSA-5619098, Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS)
R-HSA-8981373, Intestinal hexose absorption
SIGNORiP11168

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6514, 3 hits in 1005 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6514
PharosiP11168, Tchem

Protein Ontology

More...PROi		PR:P11168
RNActiP11168, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000163581, Expressed in liver and 66 other tissues
ExpressionAtlasiP11168, baseline and differential
GenevisibleiP11168, HS

Family and domain databases

Gene3Di1.20.1250.20, 1 hit
InterProiView protein in InterPro
IPR002440, Glc_transpt_2
IPR020846, MFS_dom
IPR005828, MFS_sugar_transport-like
IPR036259, MFS_trans_sf
IPR003663, Sugar/inositol_transpt
IPR005829, Sugar_transporter_CS
PfamiView protein in Pfam
PF00083, Sugar_tr, 1 hit
PRINTSiPR01191, GLUCTRSPORT2
PR00171, SUGRTRNSPORT
SUPFAMiSSF103473, SSF103473, 1 hit
TIGRFAMsiTIGR00879, SP, 1 hit
PROSITEiView protein in PROSITE
PS50850, MFS, 1 hit
PS00216, SUGAR_TRANSPORT_1, 1 hit
PS00217, SUGAR_TRANSPORT_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGTR2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P11168
Secondary accession number(s): A8K481
, B2R936, B7Z547, F8W8V8, Q9UCW9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: September 29, 2021
This is version 204 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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