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Protein

Solute carrier family 2, facilitated glucose transporter member 1

Gene

SLC2A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Facilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei317Monosaccharide1
Binding sitei388Monosaccharide1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • dehydroascorbic acid transmembrane transporter activity Source: Reactome
  • D-glucose transmembrane transporter activity Source: UniProtKB
  • glucose transmembrane transporter activity Source: UniProtKB
  • identical protein binding Source: IntAct
  • kinase binding Source: Ensembl
  • protein self-association Source: UniProtKB
  • xenobiotic transmembrane transporter activity Source: Ensembl

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processSugar transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-189200 Cellular hexose transport
R-HSA-196836 Vitamin C (ascorbate) metabolism
R-HSA-422356 Regulation of insulin secretion
R-HSA-5619043 Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1)
R-HSA-5653890 Lactose synthesis

SIGNOR Signaling Network Open Resource

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SIGNORi
P11166

Protein family/group databases

Transport Classification Database

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TCDBi
2.A.1.1.28 the major facilitator superfamily (mfs)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 1
Alternative name(s):
Glucose transporter type 1, erythrocyte/brain
Short name:
GLUT-1
HepG2 glucose transporter
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC2A1
Synonyms:GLUT1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000117394.19

Human Gene Nomenclature Database

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HGNCi
HGNC:11005 SLC2A1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
138140 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P11166

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 11Cytoplasmic1 PublicationAdd BLAST11
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei12 – 33Helical; Name=1Add BLAST22
Topological domaini34 – 66Extracellular1 PublicationAdd BLAST33
Transmembranei67 – 87Helical; Name=2Add BLAST21
Topological domaini88 – 90Cytoplasmic1 Publication3
Transmembranei91 – 112Helical; Name=3Add BLAST22
Topological domaini113 – 120Extracellular1 Publication8
Transmembranei121 – 144Helical; Name=4Add BLAST24
Topological domaini145 – 155Cytoplasmic1 PublicationAdd BLAST11
Transmembranei156 – 176Helical; Name=5Add BLAST21
Topological domaini177 – 185Extracellular1 Publication9
Transmembranei186 – 206Helical; Name=6Add BLAST21
Topological domaini207 – 271Cytoplasmic1 PublicationAdd BLAST65
Transmembranei272 – 293Helical; Name=7Add BLAST22
Topological domaini294 – 306Extracellular1 PublicationAdd BLAST13
Transmembranei307 – 328Helical; Name=8Add BLAST22
Topological domaini329 – 334Cytoplasmic1 Publication6
Transmembranei335 – 355Helical; Name=9Add BLAST21
Topological domaini356 – 365Extracellular1 Publication10
Transmembranei366 – 388Helical; Name=10Add BLAST23
Topological domaini389 – 401Cytoplasmic1 PublicationAdd BLAST13
Transmembranei402 – 422Helical; Name=11Add BLAST21
Topological domaini423 – 429Extracellular1 Publication7
Transmembranei430 – 450Helical; Name=12Add BLAST21
Topological domaini451 – 492Cytoplasmic1 PublicationAdd BLAST42

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

GLUT1 deficiency syndrome 1 (GLUT1DS1)11 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA neurologic disorder showing wide phenotypic variability. The most severe 'classic' phenotype comprises infantile-onset epileptic encephalopathy associated with delayed development, acquired microcephaly, motor incoordination, and spasticity. Onset of seizures, usually characterized by apneic episodes, staring spells, and episodic eye movements, occurs within the first 4 months of life. Other paroxysmal findings include intermittent ataxia, confusion, lethargy, sleep disturbance, and headache. Varying degrees of cognitive impairment can occur, ranging from learning disabilities to severe mental retardation.
See also OMIM:606777
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05475634N → S in GLUT1DS1; 55% of wild-type glucose uptake activity. 1 Publication1
Natural variantiVAR_06520634N → Y in GLUT1DS1. 1 Publication1
Natural variantiVAR_01328366S → F in GLUT1DS1. 1 PublicationCorresponds to variant dbSNP:rs80359813Ensembl.1
Natural variantiVAR_01318291G → D in GLUT1DS1; significantly decreases the transport of 3-O-methyl-D-glucose. 2 PublicationsCorresponds to variant dbSNP:rs80359814EnsemblClinVar.1
Natural variantiVAR_06520996M → V in GLUT1DS1. 1 PublicationCorresponds to variant dbSNP:rs753161833EnsemblClinVar.1
Natural variantiVAR_054757126R → C in GLUT1DS1, GLUT1DS2 and DYT9; reduced transporter activity. 3 PublicationsCorresponds to variant dbSNP:rs80359818EnsemblClinVar.1
Natural variantiVAR_013183126R → H in GLUT1DS1; significantly decreases the transport of 3-O-methyl-D-glucose and dehydroascorbic acid; 57% of wild-type glucose uptake activity. 4 PublicationsCorresponds to variant dbSNP:rs80359816EnsemblClinVar.1
Natural variantiVAR_013184126R → L in GLUT1DS1; compound heterozygote with V-256. 1 PublicationCorresponds to variant dbSNP:rs80359816EnsemblClinVar.1
Natural variantiVAR_054758130G → S in GLUT1DS1; 75% of wild-type glucose uptake activity. 2 PublicationsCorresponds to variant dbSNP:rs80359819Ensembl.1
Natural variantiVAR_013284146E → K in GLUT1DS1. 2 PublicationsCorresponds to variant dbSNP:rs80359820Ensembl.1
Natural variantiVAR_054759153R → C in GLUT1DS1; 44% of wild-type glucose uptake activity. 2 Publications1
Natural variantiVAR_065211155A → V in GLUT1DS1. 1 Publication1
Natural variantiVAR_054760169Missing in GLUT1DS1; 48% of wild-type glucose uptake activity. 1 Publication1
Natural variantiVAR_065214212R → H in GLUT1DS1. 1 PublicationCorresponds to variant dbSNP:rs886039517EnsemblClinVar.1
Natural variantiVAR_065216223R → W in GLUT1DS1. 1 PublicationCorresponds to variant dbSNP:rs796053248EnsemblClinVar.1
Natural variantiVAR_013185256K → E in GLUT1DS1; compound heterozygote with L-126. 1 PublicationCorresponds to variant dbSNP:rs121909738Ensembl.1
Natural variantiVAR_069079292Y → YY in GLUT1DS1. 1 Publication1
Natural variantiVAR_054763295T → M in GLUT1DS1; 75% of wild-type glucose uptake activity. 2 PublicationsCorresponds to variant dbSNP:rs80359823EnsemblClinVar.1
Natural variantiVAR_013285310T → I in GLUT1DS1. 1 PublicationCorresponds to variant dbSNP:rs80359824Ensembl.1
Natural variantiVAR_065220329E → Q in GLUT1DS1; stabilizes the inward-open conformation. 1 Publication1
Natural variantiVAR_013286333R → W in GLUT1DS1; 43% of wild-type glucose uptake activity. 3 PublicationsCorresponds to variant dbSNP:rs80359825EnsemblClinVar.1
Natural variantiVAR_065222382G → D in GLUT1DS1. 1 Publication1
Natural variantiVAR_065223405A → D in GLUT1DS1. 1 Publication1
Natural variantiVAR_069080468R → W in GLUT1DS1. 1 PublicationCorresponds to variant dbSNP:rs267607059EnsemblClinVar.1
Natural variantiVAR_065224485P → L in GLUT1DS1. 1 Publication1
GLUT1 deficiency syndrome 2 (GLUT1DS2)9 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA clinically variable disorder characterized primarily by onset in childhood of paroxysmal exercise-induced dyskinesia. The dyskinesia involves transient abnormal involuntary movements, such as dystonia and choreoathetosis, induced by exercise or exertion, and affecting the exercised limbs. Some patients may also have epilepsy, most commonly childhood absence epilepsy. Mild mental retardation may also occur. In some patients involuntary exertion-induced dystonic, choreoathetotic, and ballistic movements may be associated with macrocytic hemolytic anemia.
See also OMIM:612126
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05475534N → I in GLUT1DS2. 1 PublicationCorresponds to variant dbSNP:rs80359812EnsemblClinVar.1
Natural variantiVAR_06907792R → W in GLUT1DS2. 1 PublicationCorresponds to variant dbSNP:rs202060209EnsemblClinVar.1
Natural variantiVAR_06520793R → W in GLUT1DS2. 1 PublicationCorresponds to variant dbSNP:rs267607061EnsemblClinVar.1
Natural variantiVAR_06520895S → I in GLUT1DS2. 1 PublicationCorresponds to variant dbSNP:rs267607060EnsemblClinVar.1
Natural variantiVAR_065210153R → H in GLUT1DS2. 1 PublicationCorresponds to variant dbSNP:rs794727642EnsemblClinVar.1
Natural variantiVAR_065212165V → I in GLUT1DS2. 1 PublicationCorresponds to variant dbSNP:rs1057520545Ensembl.1
Natural variantiVAR_054761275A → T in GLUT1DS2; the mutation decreases glucose transport but does not affect cation permeability. 1 PublicationCorresponds to variant dbSNP:rs121909740EnsemblClinVar.1
Natural variantiVAR_054762282 – 285Missing in GLUT1DS2; accompanied by hemolytic anemia and altered erythrocyte ion concentrations; the mutation decreases glucose transport and causes a cation leak that alteres intracellular concentrations of sodium potassium and calcium. 1 Publication4
Natural variantiVAR_065784294S → P in GLUT1DS2. 1 Publication1
Natural variantiVAR_054764314G → S in GLUT1DS2; the mutation decreases glucose transport but does not affect cation permeability. 2 PublicationsCorresponds to variant dbSNP:rs121909739EnsemblClinVar.1
Natural variantiVAR_065218317N → T in GLUT1DS2. 1 Publication1
Natural variantiVAR_065219324S → L in GLUT1DS2; mild phenotype; reduced transporter activity. 2 PublicationsCorresponds to variant dbSNP:rs796053253EnsemblClinVar.1
Epilepsy, idiopathic generalized 12 (EIG12)3 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Generalized seizures arise diffusely and simultaneously from both hemispheres of the brain. Seizure types include juvenile myoclonic seizures, absence seizures, and generalized tonic-clonic seizures. In some EIG12 patients seizures may remit with age.
See also OMIM:614847
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07622651R → H in EIG12; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs201815571Ensembl.1
Natural variantiVAR_07622760T → M in EIG12; unknown pathological significance; decreased glucose transport. 1 PublicationCorresponds to variant dbSNP:rs142986731EnsemblClinVar.1
Natural variantiVAR_07622877M → T in EIG12; decreased glucose transport. 1 Publication1
Natural variantiVAR_076229149P → A in EIG12; unknown pathological significance. 1 Publication1
Natural variantiVAR_076230218R → S in EIG12; decreased glucose transport. 1 Publication1
Natural variantiVAR_065215223R → P in EIG12; mild phenotype; reduced transporter activity. 2 PublicationsCorresponds to variant dbSNP:rs397514564EnsemblClinVar.1
Natural variantiVAR_076231223R → Q in EIG12; unknown pathological significance; no effect on glucose transport. 1 PublicationCorresponds to variant dbSNP:rs397514564EnsemblClinVar.1
Natural variantiVAR_069078232R → C in EIG12; the mutant protein is expressed at the cell surface but has mildly decreased glucose uptake (70%) compared to wild-type. 1 PublicationCorresponds to variant dbSNP:rs387907313EnsemblClinVar.1
Natural variantiVAR_076232243E → V in EIG12; decreased glucose transport. 1 Publication1
Natural variantiVAR_076234411N → S in EIG12; decreased glucose transport. 1 PublicationCorresponds to variant dbSNP:rs398123069EnsemblClinVar.1
Natural variantiVAR_076236458R → W in EIG12; decreased glucose transport. 1 PublicationCorresponds to variant dbSNP:rs13306758EnsemblClinVar.1
Dystonia 9 (DYT9)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant neurologic disorder characterized by childhood onset of paroxysmal choreoathetosis and progressive spastic paraplegia. Most patients show some degree of cognitive impairment. Other variable features may include seizures, migraine headaches, and ataxia.
See also OMIM:601042
Stomatin-deficient cryohydrocytosis with neurologic defects (SDCHCN)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare form of stomatocytosis characterized by episodic hemolytic anemia, cold-induced red cells cation leak, erratic hyperkalemia, neonatal hyperbilirubinemia, hepatosplenomegaly, cataracts, seizures, mental retardation, and movement disorder.
See also OMIM:608885
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_076233286G → D in SDCHCN; no effect on protein abundance; no effect on localization to the plasma membrane; loss of D-glucose transporter activity; increased cation leakage. 2 PublicationsCorresponds to variant dbSNP:rs864309514EnsemblClinVar.1
Natural variantiVAR_076235435Missing in SDCHCN; no effect on protein abundance; no effect on localization to the plasma membrane; loss of D-glucose transporter activity; increased cation leakage. 2 Publications1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi45N → T: Loss of glycosylation site. 1 Publication1
Mutagenesisi192I → C: Strongly decreases glucose transport. 1 Publication1
Mutagenesisi204L → C: Abolishes glucose transport. 1 Publication1
Mutagenesisi205P → C: Abolishes glucose transport. 1 Publication1
Mutagenesisi340G → C: Strongly decreases glucose transport. 1 Publication1

Keywords - Diseasei

Cataract, Disease mutation, Dystonia, Epilepsy, Hereditary hemolytic anemia, Mental retardation

Organism-specific databases

DisGeNET

More...
DisGeNETi
6513

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
SLC2A1

MalaCards human disease database

More...
MalaCardsi
SLC2A1
MIMi601042 phenotype
606777 phenotype
608885 phenotype
612126 phenotype
614847 phenotype

Open Targets

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OpenTargetsi
ENSG00000117394

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
64280 Childhood absence epilepsy
71277 Encephalopathy due to GLUT1 deficiency
168577 Hereditary cryohydrocytosis with reduced stomatin
53583 Paroxysmal dystonic choreathetosis with episodic ataxia and spasticity
98811 Paroxysmal exertion-induced dyskinesia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA35875

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL2535

Drug and drug target database

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DrugBanki
DB08831 2-deoxyglucose
DB08830 Dehydroascorbic Acid
DB00292 Etomidate
DB09502 Fludeoxyglucose F-18

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
875

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
SLC2A1

Domain mapping of disease mutations (DMDM)

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DMDMi
115502394

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000503381 – 492Solute carrier family 2, facilitated glucose transporter member 1Add BLAST492

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi45N-linked (GlcNAc...) asparagine2 Publications1
Modified residuei465PhosphoserineCombined sources1
Modified residuei478PhosphothreonineCombined sources1
Modified residuei490PhosphoserineCombined sources1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei411Not glycosylated1 Publication1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P11166

MaxQB - The MaxQuant DataBase

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MaxQBi
P11166

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P11166

PeptideAtlas

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PeptideAtlasi
P11166

PRoteomics IDEntifications database

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PRIDEi
P11166

ProteomicsDB human proteome resource

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ProteomicsDBi
52703

PTM databases

GlyConnect protein glycosylation platform

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GlyConnecti
573

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P11166

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P11166

SwissPalm database of S-palmitoylation events

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SwissPalmi
P11166

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
P11166

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in erythrocytes (at protein level). Expressed at variable levels in many human tissues.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000117394 Expressed in 193 organ(s), highest expression level in pigmented layer of retina

CleanEx database of gene expression profiles

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CleanExi
HS_SLC2A1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P11166 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P11166 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB002759
HPA031345
HPA058494

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with GIPC (via PDZ domain) (By similarity). Found in a complex with ADD2, DMTN and SLC2A1. Interacts (via C-terminus cytoplasmic region) with DMTN isoform 2 (PubMed:18347014). Interacts with SNX27; the interaction is required when endocytosed to prevent degradation in lysosomes and promote recycling to the plasma membrane (PubMed:23563491). Interacts with STOM (PubMed:23219802). Interacts with SGTA (via Gln-rich region) (By similarity).By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112404, 32 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-3111 Glucose transporter complex 1

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P11166

Database of interacting proteins

More...
DIPi
DIP-23N

Protein interaction database and analysis system

More...
IntActi
P11166, 38 interactors

Molecular INTeraction database

More...
MINTi
P11166

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000416293

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P11166

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1492
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P11166

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P11166

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni282 – 288Monosaccharide binding7

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0569 Eukaryota
COG0477 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156792

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG014816

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P11166

KEGG Orthology (KO)

More...
KOi
K07299

Identification of Orthologs from Complete Genome Data

More...
OMAi
SNMVPIY

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0A9K

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P11166

TreeFam database of animal gene trees

More...
TreeFami
TF313762

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06174 MFS, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002439 Glu_transpt_1
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00083 Sugar_tr, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01190 GLUCTRSPORT1
PR00171 SUGRTRNSPORT

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103473 SSF103473, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00879 SP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit
PS00217 SUGAR_TRANSPORT_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P11166-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPSSKKLTG RLMLAVGGAV LGSLQFGYNT GVINAPQKVI EEFYNQTWVH
60 70 80 90 100
RYGESILPTT LTTLWSLSVA IFSVGGMIGS FSVGLFVNRF GRRNSMLMMN
110 120 130 140 150
LLAFVSAVLM GFSKLGKSFE MLILGRFIIG VYCGLTTGFV PMYVGEVSPT
160 170 180 190 200
ALRGALGTLH QLGIVVGILI AQVFGLDSIM GNKDLWPLLL SIIFIPALLQ
210 220 230 240 250
CIVLPFCPES PRFLLINRNE ENRAKSVLKK LRGTADVTHD LQEMKEESRQ
260 270 280 290 300
MMREKKVTIL ELFRSPAYRQ PILIAVVLQL SQQLSGINAV FYYSTSIFEK
310 320 330 340 350
AGVQQPVYAT IGSGIVNTAF TVVSLFVVER AGRRTLHLIG LAGMAGCAIL
360 370 380 390 400
MTIALALLEQ LPWMSYLSIV AIFGFVAFFE VGPGPIPWFI VAELFSQGPR
410 420 430 440 450
PAAIAVAGFS NWTSNFIVGM CFQYVEQLCG PYVFIIFTVL LVLFFIFTYF
460 470 480 490
KVPETKGRTF DEIASGFRQG GASQSDKTPE ELFHPLGADS QV
Length:492
Mass (Da):54,084
Last modified:October 3, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE71E1C6BD1B00B1E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0D9SFK9A0A0D9SFK9_HUMAN
Solute carrier family 2, facilitate...
SLC2A1
173Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A6NL68A6NL68_HUMAN
Solute carrier family 2, facilitate...
SLC2A1
116Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0D9SG74A0A0D9SG74_HUMAN
Solute carrier family 2, facilitate...
SLC2A1
142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PQ59A0A1W2PQ59_HUMAN
Solute carrier family 2, facilitate...
SLC2A1
43Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti25 – 26Missing in BAF85480 (PubMed:14702039).Curated2
Sequence conflicti95S → L in BAF85480 (PubMed:14702039).Curated1
Sequence conflicti152L → F in AAA52571 (PubMed:3839598).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05475534N → I in GLUT1DS2. 1 PublicationCorresponds to variant dbSNP:rs80359812EnsemblClinVar.1
Natural variantiVAR_05475634N → S in GLUT1DS1; 55% of wild-type glucose uptake activity. 1 Publication1
Natural variantiVAR_06520634N → Y in GLUT1DS1. 1 Publication1
Natural variantiVAR_07622651R → H in EIG12; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs201815571Ensembl.1
Natural variantiVAR_07622760T → M in EIG12; unknown pathological significance; decreased glucose transport. 1 PublicationCorresponds to variant dbSNP:rs142986731EnsemblClinVar.1
Natural variantiVAR_01328366S → F in GLUT1DS1. 1 PublicationCorresponds to variant dbSNP:rs80359813Ensembl.1
Natural variantiVAR_07622877M → T in EIG12; decreased glucose transport. 1 Publication1
Natural variantiVAR_01318291G → D in GLUT1DS1; significantly decreases the transport of 3-O-methyl-D-glucose. 2 PublicationsCorresponds to variant dbSNP:rs80359814EnsemblClinVar.1
Natural variantiVAR_06907792R → W in GLUT1DS2. 1 PublicationCorresponds to variant dbSNP:rs202060209EnsemblClinVar.1
Natural variantiVAR_06520793R → W in GLUT1DS2. 1 PublicationCorresponds to variant dbSNP:rs267607061EnsemblClinVar.1
Natural variantiVAR_06520895S → I in GLUT1DS2. 1 PublicationCorresponds to variant dbSNP:rs267607060EnsemblClinVar.1
Natural variantiVAR_06520996M → V in GLUT1DS1. 1 PublicationCorresponds to variant dbSNP:rs753161833EnsemblClinVar.1
Natural variantiVAR_054757126R → C in GLUT1DS1, GLUT1DS2 and DYT9; reduced transporter activity. 3 PublicationsCorresponds to variant dbSNP:rs80359818EnsemblClinVar.1
Natural variantiVAR_013183126R → H in GLUT1DS1; significantly decreases the transport of 3-O-methyl-D-glucose and dehydroascorbic acid; 57% of wild-type glucose uptake activity. 4 PublicationsCorresponds to variant dbSNP:rs80359816EnsemblClinVar.1
Natural variantiVAR_013184126R → L in GLUT1DS1; compound heterozygote with V-256. 1 PublicationCorresponds to variant dbSNP:rs80359816EnsemblClinVar.1
Natural variantiVAR_054758130G → S in GLUT1DS1; 75% of wild-type glucose uptake activity. 2 PublicationsCorresponds to variant dbSNP:rs80359819Ensembl.1
Natural variantiVAR_013284146E → K in GLUT1DS1. 2 PublicationsCorresponds to variant dbSNP:rs80359820Ensembl.1
Natural variantiVAR_076229149P → A in EIG12; unknown pathological significance. 1 Publication1
Natural variantiVAR_054759153R → C in GLUT1DS1; 44% of wild-type glucose uptake activity. 2 Publications1
Natural variantiVAR_065210153R → H in GLUT1DS2. 1 PublicationCorresponds to variant dbSNP:rs794727642EnsemblClinVar.1
Natural variantiVAR_065211155A → V in GLUT1DS1. 1 Publication1
Natural variantiVAR_065212165V → I in GLUT1DS2. 1 PublicationCorresponds to variant dbSNP:rs1057520545Ensembl.1
Natural variantiVAR_054760169Missing in GLUT1DS1; 48% of wild-type glucose uptake activity. 1 Publication1
Natural variantiVAR_065213212R → C in GLUT1DS1 and DYT9. 2 PublicationsCorresponds to variant dbSNP:rs387907312EnsemblClinVar.1
Natural variantiVAR_065214212R → H in GLUT1DS1. 1 PublicationCorresponds to variant dbSNP:rs886039517EnsemblClinVar.1
Natural variantiVAR_076230218R → S in EIG12; decreased glucose transport. 1 Publication1
Natural variantiVAR_065215223R → P in EIG12; mild phenotype; reduced transporter activity. 2 PublicationsCorresponds to variant dbSNP:rs397514564EnsemblClinVar.1
Natural variantiVAR_076231223R → Q in EIG12; unknown pathological significance; no effect on glucose transport. 1 PublicationCorresponds to variant dbSNP:rs397514564EnsemblClinVar.1
Natural variantiVAR_065216223R → W in GLUT1DS1. 1 PublicationCorresponds to variant dbSNP:rs796053248EnsemblClinVar.1
Natural variantiVAR_069078232R → C in EIG12; the mutant protein is expressed at the cell surface but has mildly decreased glucose uptake (70%) compared to wild-type. 1 PublicationCorresponds to variant dbSNP:rs387907313EnsemblClinVar.1
Natural variantiVAR_076232243E → V in EIG12; decreased glucose transport. 1 Publication1
Natural variantiVAR_013185256K → E in GLUT1DS1; compound heterozygote with L-126. 1 PublicationCorresponds to variant dbSNP:rs121909738Ensembl.1
Natural variantiVAR_054761275A → T in GLUT1DS2; the mutation decreases glucose transport but does not affect cation permeability. 1 PublicationCorresponds to variant dbSNP:rs121909740EnsemblClinVar.1
Natural variantiVAR_054762282 – 285Missing in GLUT1DS2; accompanied by hemolytic anemia and altered erythrocyte ion concentrations; the mutation decreases glucose transport and causes a cation leak that alteres intracellular concentrations of sodium potassium and calcium. 1 Publication4
Natural variantiVAR_076233286G → D in SDCHCN; no effect on protein abundance; no effect on localization to the plasma membrane; loss of D-glucose transporter activity; increased cation leakage. 2 PublicationsCorresponds to variant dbSNP:rs864309514EnsemblClinVar.1
Natural variantiVAR_069079292Y → YY in GLUT1DS1. 1 Publication1
Natural variantiVAR_065784294S → P in GLUT1DS2. 1 Publication1
Natural variantiVAR_054763295T → M in GLUT1DS1; 75% of wild-type glucose uptake activity. 2 PublicationsCorresponds to variant dbSNP:rs80359823EnsemblClinVar.1
Natural variantiVAR_065217303V → L Found in a patient with GLUT1 deficiency syndrome. 1 Publication1
Natural variantiVAR_013285310T → I in GLUT1DS1. 1 PublicationCorresponds to variant dbSNP:rs80359824Ensembl.1
Natural variantiVAR_054764314G → S in GLUT1DS2; the mutation decreases glucose transport but does not affect cation permeability. 2 PublicationsCorresponds to variant dbSNP:rs121909739EnsemblClinVar.1
Natural variantiVAR_065218317N → T in GLUT1DS2. 1 Publication1
Natural variantiVAR_065219324S → L in GLUT1DS2; mild phenotype; reduced transporter activity. 2 PublicationsCorresponds to variant dbSNP:rs796053253EnsemblClinVar.1
Natural variantiVAR_065220329E → Q in GLUT1DS1; stabilizes the inward-open conformation. 1 Publication1
Natural variantiVAR_065221333R → Q in GLUT1DS1 and GLUT1DS2. 2 Publications1
Natural variantiVAR_013286333R → W in GLUT1DS1; 43% of wild-type glucose uptake activity. 3 PublicationsCorresponds to variant dbSNP:rs80359825EnsemblClinVar.1
Natural variantiVAR_065222382G → D in GLUT1DS1. 1 Publication1
Natural variantiVAR_065223405A → D in GLUT1DS1. 1 Publication1
Natural variantiVAR_076234411N → S in EIG12; decreased glucose transport. 1 PublicationCorresponds to variant dbSNP:rs398123069EnsemblClinVar.1
Natural variantiVAR_076235435Missing in SDCHCN; no effect on protein abundance; no effect on localization to the plasma membrane; loss of D-glucose transporter activity; increased cation leakage. 2 Publications1
Natural variantiVAR_076236458R → W in EIG12; decreased glucose transport. 1 PublicationCorresponds to variant dbSNP:rs13306758EnsemblClinVar.1
Natural variantiVAR_069080468R → W in GLUT1DS1. 1 PublicationCorresponds to variant dbSNP:rs267607059EnsemblClinVar.1
Natural variantiVAR_065224485P → L in GLUT1DS1. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
K03195 mRNA Translation: AAA52571.1
AK292791 mRNA Translation: BAF85480.1
AK312403 mRNA Translation: BAG35317.1
CH471059 Genomic DNA Translation: EAX07124.1
BC118590 mRNA Translation: AAI18591.1
M20653 Genomic DNA Translation: AAB61084.1
AF070544 mRNA Translation: AAC28635.1
AY034633 mRNA Translation: AAK56795.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS477.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A27217

NCBI Reference Sequences

More...
RefSeqi
NP_006507.2, NM_006516.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.473721

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000426263; ENSP00000416293; ENSG00000117394

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6513

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6513

UCSC genome browser

More...
UCSCi
uc001cik.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

GLUT1 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K03195 mRNA Translation: AAA52571.1
AK292791 mRNA Translation: BAF85480.1
AK312403 mRNA Translation: BAG35317.1
CH471059 Genomic DNA Translation: EAX07124.1
BC118590 mRNA Translation: AAI18591.1
M20653 Genomic DNA Translation: AAB61084.1
AF070544 mRNA Translation: AAC28635.1
AY034633 mRNA Translation: AAK56795.1
CCDSiCCDS477.1
PIRiA27217
RefSeqiNP_006507.2, NM_006516.2
UniGeneiHs.473721

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SUKmodel-A1-492[»]
4PYPX-ray3.17A1-492[»]
5EQGX-ray2.90A1-492[»]
5EQHX-ray2.99A1-492[»]
5EQIX-ray3.00A1-492[»]
ProteinModelPortaliP11166
SMRiP11166
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112404, 32 interactors
ComplexPortaliCPX-3111 Glucose transporter complex 1
CORUMiP11166
DIPiDIP-23N
IntActiP11166, 38 interactors
MINTiP11166
STRINGi9606.ENSP00000416293

Chemistry databases

BindingDBiP11166
ChEMBLiCHEMBL2535
DrugBankiDB08831 2-deoxyglucose
DB08830 Dehydroascorbic Acid
DB00292 Etomidate
DB09502 Fludeoxyglucose F-18
GuidetoPHARMACOLOGYi875

Protein family/group databases

TCDBi2.A.1.1.28 the major facilitator superfamily (mfs)

PTM databases

GlyConnecti573
iPTMnetiP11166
PhosphoSitePlusiP11166
SwissPalmiP11166
UniCarbKBiP11166

Polymorphism and mutation databases

BioMutaiSLC2A1
DMDMi115502394

Proteomic databases

EPDiP11166
MaxQBiP11166
PaxDbiP11166
PeptideAtlasiP11166
PRIDEiP11166
ProteomicsDBi52703

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000426263; ENSP00000416293; ENSG00000117394
GeneIDi6513
KEGGihsa:6513
UCSCiuc001cik.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6513
DisGeNETi6513
EuPathDBiHostDB:ENSG00000117394.19

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SLC2A1
GeneReviewsiSLC2A1
HGNCiHGNC:11005 SLC2A1
HPAiCAB002759
HPA031345
HPA058494
MalaCardsiSLC2A1
MIMi138140 gene
601042 phenotype
606777 phenotype
608885 phenotype
612126 phenotype
614847 phenotype
neXtProtiNX_P11166
OpenTargetsiENSG00000117394
Orphaneti64280 Childhood absence epilepsy
71277 Encephalopathy due to GLUT1 deficiency
168577 Hereditary cryohydrocytosis with reduced stomatin
53583 Paroxysmal dystonic choreathetosis with episodic ataxia and spasticity
98811 Paroxysmal exertion-induced dyskinesia
PharmGKBiPA35875

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0569 Eukaryota
COG0477 LUCA
GeneTreeiENSGT00940000156792
HOVERGENiHBG014816
InParanoidiP11166
KOiK07299
OMAiSNMVPIY
OrthoDBiEOG091G0A9K
PhylomeDBiP11166
TreeFamiTF313762

Enzyme and pathway databases

ReactomeiR-HSA-189200 Cellular hexose transport
R-HSA-196836 Vitamin C (ascorbate) metabolism
R-HSA-422356 Regulation of insulin secretion
R-HSA-5619043 Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1)
R-HSA-5653890 Lactose synthesis
SIGNORiP11166

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SLC2A1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
GLUT1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6513

Protein Ontology

More...
PROi
PR:P11166

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000117394 Expressed in 193 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_SLC2A1
ExpressionAtlasiP11166 baseline and differential
GenevisibleiP11166 HS

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR002439 Glu_transpt_1
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
PRINTSiPR01190 GLUCTRSPORT1
PR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit
PS00217 SUGAR_TRANSPORT_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGTR1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P11166
Secondary accession number(s): A8K9S6
, B2R620, D3DPX0, O75535, Q147X2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: October 3, 2006
Last modified: December 5, 2018
This is version 224 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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