EGR2

Functionⁱ

Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4.1 Publication

E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 own transcriptional activity.1 Publication

Pathwayⁱ: protein sumoylation

This protein is involved in the pathway protein sumoylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein sumoylation and in Protein modification.

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	340 – 364	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	370 – 392	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	398 – 420	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

chromatin binding Source: UniProtKB
DNA-binding transcription factor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 14532282
HMG box domain binding Source: Ensembl
metal ion binding Source: UniProtKB-KW
RNA polymerase II activating transcription factor binding Source: BHF-UCL
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 12687019
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 12687019
transcription regulatory region DNA binding Source: UniProtKB
transferase activity Source: UniProtKB-KW
ubiquitin protein ligase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 19651900

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

brain development
Source: ProtInc
Traceable author statementⁱ
- 9537424
brain segmentation Source: Ensembl
cellular response to organic substance Source: Ensembl
facial nerve structural organization Source: Ensembl
fat cell differentiation Source: BHF-UCL
learning or memory Source: Ensembl
motor neuron axon guidance Source: Ensembl
myelination Source: Ensembl
peripheral nervous system development
Source: ProtInc
Traceable author statementⁱ
- 9537424
positive regulation of transcription, DNA-templated Source: UniProtKB
positive regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from direct assayⁱ
- 12687019
protein export from nucleus Source: UniProtKB
protein sumoylation Source: UniProtKB-UniPathway
regulation of neuronal synaptic plasticity Source: Ensembl
regulation of ossification Source: Ensembl
response to insulin Source: Ensembl
rhombomere 3 formation Source: Ensembl
rhombomere 5 formation Source: Ensembl
rhythmic behavior Source: Ensembl
Schwann cell differentiation Source: Ensembl
skeletal muscle cell differentiation Source: Ensembl
transcription by RNA polymerase II Source: BHF-UCL

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding, Transferase
Biological process	Transcription, Transcription regulation, Ubl conjugation pathway
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381340 Transcriptional regulation of white adipocyte differentiation R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis
SignaLinkⁱ	P11161
SIGNORⁱ	P11161
UniPathwayⁱ	UPA00886

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: E3 SUMO-protein ligase EGR2 (EC:2.3.2.-) Alternative name(s): AT591 E3 SUMO-protein transferase ERG2Curated Early growth response protein 2 Short name: EGR-2 Zinc finger protein Krox-20
Gene namesⁱ	Name:EGR2 Synonyms:KROX20
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000122877.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3239 EGR2
MIMⁱ	129010 gene
neXtProtⁱ	NX_P11161

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Neuropathy, congenital hypomyelinating or amyelinating (CHN)2 Publications

The disease is caused by mutations affecting the gene represented in this entry. Patients affected by the amyelinating form carry a causative, homozygous deletion encompassing a myelin-specific enhancer of EGR2 (PubMed:22522483).1 Publication

Disease descriptionA severe degenerating neuropathy that results from a congenital impairment in myelin formation. It is clinically characterized by early onset of hypotonia, areflexia, distal muscle weakness, and very slow nerve conduction velocities (as low as 3m/s). Some patients manifest nearly complete absence of spontaneous limb movements, respiratory distress at birth, and complete absence of myelin shown by electron microscopy of peripheral nerves. Inheritance can be autosomal dominant or recessive.

Charcot-Marie-Tooth disease 1D (CMT1D)8 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA dominant demyelinating form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Demyelinating neuropathies are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet.

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_007736	355	D → V in CMT1D. 2 Publications	1
Natural variantⁱVAR_029958	381	R → C in CMT1D. 1 Publication	1
Natural variantⁱVAR_009875	381	R → H in CMT1D. 1 PublicationCorresponds to variant dbSNP:rs281865137EnsemblClinVar.	1
Natural variantⁱVAR_029959	383	D → Y in CMT1D. 1 PublicationCorresponds to variant dbSNP:rs104894160EnsemblClinVar.	1
Natural variantⁱVAR_007738	409	R → W in CMT1D. 1 PublicationCorresponds to variant dbSNP:rs104894159EnsemblClinVar.	1

Dejerine-Sottas syndrome (DSS)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA severe degenerating neuropathy of the demyelinating Charcot-Marie-Tooth disease category, with onset by age 2 years. Characterized by motor and sensory neuropathy with very slow nerve conduction velocities, increased cerebrospinal fluid protein concentrations, hypertrophic nerve changes, delayed age of walking as well as areflexia. There are both autosomal dominant and autosomal recessive forms of Dejerine-Sottas syndrome.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	162 – 165	DHLY → AAAA: Inhibits association with HCFC1. 1 Publication		4

Keywords - Diseaseⁱ

Charcot-Marie-Tooth disease, Dejerine-Sottas syndrome, Disease mutation, Neurodegeneration, Neuropathy

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1959
GeneReviewsⁱ	EGR2
MalaCards human disease database More...MalaCardsⁱ	EGR2
MIMⁱ	145900 phenotype 605253 phenotype 607678 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000122877
Orphanetⁱ	101084 Charcot-Marie-Tooth disease type 1D 99951 Charcot-Marie-Tooth disease type 4E 64748 Dejerine-Sottas syndrome
PharmGKBⁱ	PA27674

Polymorphism and mutation databases

BioMutaⁱ	EGR2
DMDMⁱ	33112654

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047119	1 – 476	E3 SUMO-protein ligase EGR2Add BLAST		476

Post-translational modificationⁱ

Ubiquitinated by WWP2 leading to proteasomal degradation.By similarity

Keywords - PTMⁱ

Ubl conjugation

Proteomic databases

PaxDbⁱ	P11161
PeptideAtlas More...PeptideAtlasⁱ	P11161
PRIDEⁱ	P11161
ProteomicsDBⁱ	52701 52702 [P11161-2]

PTM databases

iPTMnetⁱ	P11161
PhosphoSitePlusⁱ	P11161

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000122877 Expressed in 88 organ(s), highest expression level in tibial nerve
CleanExⁱ	HS_EGR2
ExpressionAtlasⁱ	P11161 baseline and differential

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA031165

HPAⁱ

HPA031165

Interactionⁱ

Subunit structureⁱ

Interacts with HCFC1. Interacts with WWP2. Interacts with UBC9.3 Publications

GO - Molecular functionⁱ

HMG box domain binding Source: Ensembl
RNA polymerase II activating transcription factor binding Source: BHF-UCL
ubiquitin protein ligase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 19651900

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	108279, 17 interactors
IntActⁱ	P11161, 10 interactors
Molecular INTeraction database More...MINTⁱ	P11161
STRINGⁱ	9606.ENSP00000242480

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P11161
SMRⁱ	P11161
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	162 – 165	HCFC1-binding-motif (HBM)		4

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	300 – 309	Poly-Ala		10

Sequence similaritiesⁱ

Belongs to the EGR C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	340 – 364	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	370 – 392	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	398 – 420	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074455
HOGENOMⁱ	HOG000036856
HOVERGENⁱ	HBG003909
InParanoidⁱ	P11161
KEGG Orthology (KO) More...KOⁱ	K12496
OMAⁱ	FPPQCQR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06VX
PhylomeDBⁱ	P11161
TreeFamⁱ	TF318980

Family and domain databases

InterProⁱ	View protein in InterPro IPR021849 EGR IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF11928 DUF3446, 1 hit PF00096 zf-C2H2, 3 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 3 hits
SUPFAMⁱ	SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform Long (identifier: P11161-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMTAKAVDKI PVTLSGFVHQ LSDNIYPVED LAATSVTIFP NAELGGPFDQ 
        60         70         80         90        100
MNGVAGDGMI NIDMTGEKRS LDLPYPSSFA PVSAPRNQTF TYMGKFSIDP 
       110        120        130        140        150
QYPGASCYPE GIINIVSAGI LQGVTSPAST TASSSVTSAS PNPLATGPLG 
       160        170        180        190        200
VCTMSQTQPD LDHLYSPPPP PPPYSGCAGD LYQDPSAFLS AATTSTSSSL 
       210        220        230        240        250
AYPPPPSYPS PKPATDPGLF PMIPDYPGFF PSQCQRDLHG TAGPDRKPFP 
       260        270        280        290        300
CPLDTLRVPP PLTPLSTIRN FTLGGPSAGV TGPGASGGSE GPRLPGSSSA 
       310        320        330        340        350
AAAAAAAAAY NPHHLPLRPI LRPRKYPNRP SKTPVHERPY PCPAEGCDRR 
       360        370        380        390        400
FSRSDELTRH IRIHTGHKPF QCRICMRNFS RSDHLTTHIR THTGEKPFAC 
       410        420        430        440        450
DYCGRKFARS DERKRHTKIH LRQKERKSSA PSASVPAPST ASCSGGVQPG 
       460        470 
GTLCSSNSSS LGGGPLAPCS SRTRTP

Length:476

Mass (Da):50,302

Last modified:July 19, 2003 - v3

Checksum:ⁱ7810D1B1B418DF1F

GO

Isoform Short (identifier: P11161-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-50: Missing.

« Hide

        10         20         30         40         50
MNGVAGDGMI NIDMTGEKRS LDLPYPSSFA PVSAPRNQTF TYMGKFSIDP 
        60         70         80         90        100
QYPGASCYPE GIINIVSAGI LQGVTSPAST TASSSVTSAS PNPLATGPLG 
       110        120        130        140        150
VCTMSQTQPD LDHLYSPPPP PPPYSGCAGD LYQDPSAFLS AATTSTSSSL 
       160        170        180        190        200
AYPPPPSYPS PKPATDPGLF PMIPDYPGFF PSQCQRDLHG TAGPDRKPFP 
       210        220        230        240        250
CPLDTLRVPP PLTPLSTIRN FTLGGPSAGV TGPGASGGSE GPRLPGSSSA 
       260        270        280        290        300
AAAAAAAAAY NPHHLPLRPI LRPRKYPNRP SKTPVHERPY PCPAEGCDRR 
       310        320        330        340        350
FSRSDELTRH IRIHTGHKPF QCRICMRNFS RSDHLTTHIR THTGEKPFAC 
       360        370        380        390        400
DYCGRKFARS DERKRHTKIH LRQKERKSSA PSASVPAPST ASCSGGVQPG 
       410        420 
GTLCSSNSSS LGGGPLAPCS SRTRTP

Note: No experimental confirmation available.

Show »

Length:426

Mass (Da):44,970

Checksum:ⁱDD358E32D00B4353

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A1B0GUL0	A0A1B0GUL0_HUMAN		E3 SUMO-protein ligase EGR2 E3 SUMO-protein ligase EGR2	EGR2	139	Annotation score:

Sequence cautionⁱ

The sequence AAA52372 differs from that shown. Reason: Frameshift at position 449.Curated

The sequence AAA52372 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	68	K → R in CAH18435 (PubMed:17974005).Curated	1
Sequence conflictⁱ	247	K → KPFPCPLDTLRVPPPLTPLS TIRK in AAH35625 (PubMed:15489334).Curated	1
Sequence conflictⁱ	280	V → M in AAA52372 (PubMed:3140236).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_007735	268	I → N in CHN. 1 PublicationCorresponds to variant dbSNP:rs104894158EnsemblClinVar.	1
Natural variantⁱVAR_007736	355	D → V in CMT1D. 2 Publications	1
Natural variantⁱVAR_009874	359	R → W in DSS and CMT1D; associated with A-136 in the GJB1 gene in a DSS Korean girl. 3 PublicationsCorresponds to variant dbSNP:rs104894161EnsemblClinVar.	1
Natural variantⁱVAR_029958	381	R → C in CMT1D. 1 Publication	1
Natural variantⁱVAR_009875	381	R → H in CMT1D. 1 PublicationCorresponds to variant dbSNP:rs281865137EnsemblClinVar.	1
Natural variantⁱVAR_007737	382 – 383	SD → RY in CHN.	2
Natural variantⁱVAR_029959	383	D → Y in CMT1D. 1 PublicationCorresponds to variant dbSNP:rs104894160EnsemblClinVar.	1
Natural variantⁱVAR_007738	409	R → W in CMT1D. 1 PublicationCorresponds to variant dbSNP:rs104894159EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_006863	1 – 50	Missing in isoform Short. 1 PublicationAdd BLAST		50

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J04076 mRNA Translation: AAA52372.1 Sequence problems. AF139463 mRNA Translation: AAD24588.1 AK091399 mRNA Translation: BAG52349.1 AK312813 mRNA Translation: BAG35671.1 CR749641 mRNA Translation: CAH18435.1 AL133417 Genomic DNA No translation available. CH471083 Genomic DNA Translation: EAW54238.1 CH471083 Genomic DNA Translation: EAW54239.1 BC035625 mRNA Translation: AAH35625.1 X53700 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS44409.1 [P11161-2] CCDS7267.1 [P11161-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_000390.2, NM_000399.4 [P11161-1] NP_001129649.1, NM_001136177.2 [P11161-1] NP_001129650.1, NM_001136178.1 [P11161-1] NP_001129651.1, NM_001136179.2 [P11161-2] NP_001307966.1, NM_001321037.1 [P11161-2]
UniGeneⁱ	Hs.1395

Genome annotation databases

Ensemblⁱ	ENST00000242480; ENSP00000242480; ENSG00000122877 [P11161-1] ENST00000411732; ENSP00000387634; ENSG00000122877 [P11161-2] ENST00000439032; ENSP00000402040; ENSG00000122877 [P11161-1]
GeneIDⁱ	1959
KEGGⁱ	hsa:1959
UCSC genome browser More...UCSCⁱ	uc001jmi.4 human [P11161-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P11161	EGR2 isoform 2		PANTR		476	UniRef100_P11161
Uncharacterized protein		PANPA		476
P11161-2	EGR2 isoform 5		PANTR		426	UniRef100_P11161-2
UPI00020E39F6		HUMAN		489

Protein	Similar proteins		Species	Score	Length	Source
P11161	E3 SUMO-protein ligase EGR2		PIG		471	UniRef90_P11161
EGR2 isoform 2		PANTR		476
Uncharacterized protein		PANPA		476
Uncharacterized protein		RHIBE		542
E3 SUMO-protein ligase EGR2 (Fragment)		HUMAN		139
+89
P11161-2	EGR2 isoform 5		PANTR		426	UniRef90_P11161-2
Uncharacterized protein		FELCA		541
Uncharacterized protein		MACFA		489
Uncharacterized protein		MACNE		426
Uncharacterized protein		MACMU		418
+72

Protein	Similar proteins		Species	Score	Length	Source
P11161	E3 SUMO-protein ligase EGR2		MOUSE		470	UniRef50_P08152
E3 SUMO-protein ligase EGR2		RAT		470
E3 SUMO-protein ligase EGR2 (Fragment)		CRIGR		62
E3 SUMO-protein ligase EGR2		PIG		471
E3 SUMO-protein ligase EGR2		MESAU		468
+223

Cross-referencesⁱ

Web resourcesⁱ

Inherited peripheral neuropathies mutation db

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J04076 mRNA Translation: AAA52372.1 Sequence problems. AF139463 mRNA Translation: AAD24588.1 AK091399 mRNA Translation: BAG52349.1 AK312813 mRNA Translation: BAG35671.1 CR749641 mRNA Translation: CAH18435.1 AL133417 Genomic DNA No translation available. CH471083 Genomic DNA Translation: EAW54238.1 CH471083 Genomic DNA Translation: EAW54239.1 BC035625 mRNA Translation: AAH35625.1 X53700 Genomic DNA No translation available.
CCDSⁱ	CCDS44409.1 [P11161-2] CCDS7267.1 [P11161-1]
RefSeqⁱ	NP_000390.2, NM_000399.4 [P11161-1] NP_001129649.1, NM_001136177.2 [P11161-1] NP_001129650.1, NM_001136178.1 [P11161-1] NP_001129651.1, NM_001136179.2 [P11161-2] NP_001307966.1, NM_001321037.1 [P11161-2]
UniGeneⁱ	Hs.1395

3D structure databases

ProteinModelPortalⁱ	P11161
SMRⁱ	P11161
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108279, 17 interactors
IntActⁱ	P11161, 10 interactors
MINTⁱ	P11161
STRINGⁱ	9606.ENSP00000242480

PTM databases

iPTMnetⁱ	P11161
PhosphoSitePlusⁱ	P11161

Polymorphism and mutation databases

BioMutaⁱ	EGR2
DMDMⁱ	33112654

Proteomic databases

PaxDbⁱ	P11161
PeptideAtlasⁱ	P11161
PRIDEⁱ	P11161
ProteomicsDBⁱ	52701 52702 [P11161-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1959
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000242480; ENSP00000242480; ENSG00000122877 [P11161-1] ENST00000411732; ENSP00000387634; ENSG00000122877 [P11161-2] ENST00000439032; ENSP00000402040; ENSG00000122877 [P11161-1]
GeneIDⁱ	1959
KEGGⁱ	hsa:1959
UCSCⁱ	uc001jmi.4 human [P11161-1]

Organism-specific databases

CTDⁱ	1959
DisGeNETⁱ	1959
EuPathDBⁱ	HostDB:ENSG00000122877.13
GeneCardsⁱ	EGR2
GeneReviewsⁱ	EGR2
HGNCⁱ	HGNC:3239 EGR2
HPAⁱ	HPA031165
MalaCardsⁱ	EGR2
MIMⁱ	129010 gene 145900 phenotype 605253 phenotype 607678 phenotype
neXtProtⁱ	NX_P11161
OpenTargetsⁱ	ENSG00000122877
Orphanetⁱ	101084 Charcot-Marie-Tooth disease type 1D 99951 Charcot-Marie-Tooth disease type 4E 64748 Dejerine-Sottas syndrome
PharmGKBⁱ	PA27674
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00550000074455
HOGENOMⁱ	HOG000036856
HOVERGENⁱ	HBG003909
InParanoidⁱ	P11161
KOⁱ	K12496
OMAⁱ	FPPQCQR
OrthoDBⁱ	EOG091G06VX
PhylomeDBⁱ	P11161
TreeFamⁱ	TF318980

Enzyme and pathway databases

UniPathwayⁱ	UPA00886
Reactomeⁱ	R-HSA-381340 Transcriptional regulation of white adipocyte differentiation R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis
SignaLinkⁱ	P11161
SIGNORⁱ	P11161

Miscellaneous databases

GeneWikiⁱ	EGR2
GenomeRNAiⁱ	1959
Protein Ontology More...PROⁱ	PR:P11161
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000122877 Expressed in 88 organ(s), highest expression level in tibial nerve
CleanExⁱ	HS_EGR2
ExpressionAtlasⁱ	P11161 baseline and differential

Family and domain databases

InterProⁱ	View protein in InterPro IPR021849 EGR IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF11928 DUF3446, 1 hit PF00096 zf-C2H2, 3 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 3 hits
SUPFAMⁱ	SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	EGR2_HUMAN
Accessionⁱ	P11161Primary (citable) accession number: P11161 Secondary accession number(s): B2R724 , B3KRD7, Q68CZ5, Q8IV26, Q9UNA6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
	Last sequence update:	July 19, 2003
	Last modified:	October 10, 2018
	This is version 199 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
PATHWAY comments
Index of metabolic and biosynthesis pathways
Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

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Supporting data

UniProtKB - P11161 (EGR2_HUMAN)

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E3 SUMO-protein ligase EGR2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein sumoylation

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Pathwayⁱ: protein sumoylation

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ