UniProtKB - P11161 (EGR2_HUMAN)
E3 SUMO-protein ligase EGR2
EGR2
Functioni
Sequence-specific DNA-binding transcription factor (PubMed:17717711).
Plays a role in hindbrain segmentation by regulating the expression of a subset of homeobox containing genes and in Schwann cell myelination by regulating the expression of genes involved in the formation and maintenance of myelin (By similarity).
Binds to two EGR2-consensus sites EGR2A (5'-CTGTAGGAG-3') and EGR2B (5'-ATGTAGGTG-3') in the HOXB3 enhancer and promotes HOXB3 transcriptional activation (By similarity).
Binds to specific DNA sites located in the promoter region of HOXA4, HOXB2 and ERBB2 (By similarity).
Regulates hindbrain segmentation by controlling the expression of Hox genes, such as HOXA4, HOXB3 and HOXB2, and thereby specifying odd and even rhombomeres (By similarity).
Promotes the expression of HOXB3 in the rhombomere r5 in the hindbrain (By similarity).
Regulates myelination in the peripheral nervous system after birth, possibly by regulating the expression of myelin proteins, such as MPZ, and by promoting the differentiation of Schwann cells (By similarity).
Involved in the development of the jaw openener musculature, probably by playing a role in its innervation through trigeminal motor neurons (By similarity).
May play a role in adipogenesis, possibly by regulating the expression of CEBPB (By similarity).
By similarity1 PublicationE3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 transcriptional activity.
1 Publication: protein sumoylation Pathwayi
This protein is involved in the pathway protein sumoylation, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein sumoylation and in Protein modification.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 340 – 364 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 370 – 392 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 398 – 420 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- chromatin binding Source: UniProtKB
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: UniProtKB
- HMG box domain binding Source: Ensembl
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB
- RNA polymerase II-specific DNA-binding transcription factor binding Source: BHF-UCL
- sequence-specific DNA binding Source: UniProtKB
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
- SUMO ligase activity Source: ARUK-UCL
- transcription cis-regulatory region binding Source: UniProtKB
- ubiquitin protein ligase binding Source: UniProtKB
GO - Biological processi
- aorta development Source: Ensembl
- brain development Source: ProtInc
- brain segmentation Source: Ensembl
- cellular response to organic substance Source: Ensembl
- facial nerve structural organization Source: UniProtKB
- fat cell differentiation Source: BHF-UCL
- gene expression Source: Ensembl
- learning or memory Source: Ensembl
- motor neuron axon guidance Source: Ensembl
- myelination Source: Ensembl
- peripheral nervous system development Source: ProtInc
- positive regulation of myelination Source: UniProtKB
- positive regulation of Schwann cell differentiation Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- protein export from nucleus Source: UniProtKB
- protein sumoylation Source: ARUK-UCL
- regulation of neuronal synaptic plasticity Source: Ensembl
- regulation of ossification Source: Ensembl
- regulation of transcription by RNA polymerase II Source: GO_Central
- response to insulin Source: Ensembl
- rhombomere 3 formation Source: Ensembl
- rhombomere 3 structural organization Source: UniProtKB
- rhombomere 5 formation Source: Ensembl
- rhombomere 5 structural organization Source: UniProtKB
- rhythmic behavior Source: Ensembl
- Schwann cell differentiation Source: UniProtKB
- skeletal muscle cell differentiation Source: UniProtKB
Keywordsi
Molecular function | Activator, DNA-binding, Transferase |
Biological process | Transcription, Transcription regulation, Ubl conjugation pathway |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | P11161 |
Reactomei | R-HSA-381340, Transcriptional regulation of white adipocyte differentiation R-HSA-5617472, Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-9031628, NGF-stimulated transcription R-HSA-9619665, EGR2 and SOX10-mediated initiation of Schwann cell myelination |
SignaLinki | P11161 |
SIGNORi | P11161 |
UniPathwayi | UPA00886 |
Names & Taxonomyi
Protein namesi | Recommended name: E3 SUMO-protein ligase EGR2 (EC:2.3.2.-1 Publication)Alternative name(s): AT591 E3 SUMO-protein transferase ERG2Curated Early growth response protein 2 Short name: EGR-2 Zinc finger protein Krox-20 |
Gene namesi | Name:EGR2 Synonyms:KROX20 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3239, EGR2 |
MIMi | 129010, gene |
neXtProti | NX_P11161 |
VEuPathDBi | HostDB:ENSG00000122877 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- chromatin Source: NTNU_SB
- cytoplasm Source: UniProtKB
- intracellular membrane-bounded organelle Source: HPA
Keywords - Cellular componenti
NucleusPathology & Biotechi
Involvement in diseasei
Neuropathy, congenital hypomyelinating, 1, autosomal recessive (CHN1)3 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_007735 | 268 | I → N in CHN1; loss of large and small myelinated nerve fibers. 2 PublicationsCorresponds to variant dbSNP:rs104894158EnsemblClinVar. | 1 | |
Natural variantiVAR_007737 | 382 – 383 | SD → RY in CHN1. | 2 |
Charcot-Marie-Tooth disease 1D (CMT1D)12 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_007736 | 355 | D → V in CMT1D. 2 PublicationsCorresponds to variant dbSNP:rs1589080611EnsemblClinVar. | 1 | |
Natural variantiVAR_009874 | 359 | R → W in DSS and CMT1D; associated with A-136 in the GJB1 gene in a DSS Korean girl; loss of DNA binding and loss of transactivation activity; loss of small and large myelinated nerve fibers; residual fibers with thin myelin sheaths. 4 PublicationsCorresponds to variant dbSNP:rs104894161EnsemblClinVar. | 1 | |
Natural variantiVAR_029958 | 381 | R → C in CMT1D. 1 PublicationCorresponds to variant dbSNP:rs1589080524EnsemblClinVar. | 1 | |
Natural variantiVAR_009875 | 381 | R → H in CMT1D. 1 PublicationCorresponds to variant dbSNP:rs281865137EnsemblClinVar. | 1 | |
Natural variantiVAR_029959 | 383 | D → Y in CMT1D. 1 PublicationCorresponds to variant dbSNP:rs104894160EnsemblClinVar. | 1 | |
Natural variantiVAR_083343 | 387 | T → N in CMT1D; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs281865139EnsemblClinVar. | 1 | |
Natural variantiVAR_007738 | 409 | R → W in CMT1D. 1 PublicationCorresponds to variant dbSNP:rs104894159EnsemblClinVar. | 1 | |
Natural variantiVAR_083345 | 412 | E → G in CMT1D; loss of myelinated and unmyelinated nerve fibers. 2 PublicationsCorresponds to variant dbSNP:rs749558026EnsemblClinVar. | 1 |
Dejerine-Sottas syndrome (DSS)3 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_009874 | 359 | R → W in DSS and CMT1D; associated with A-136 in the GJB1 gene in a DSS Korean girl; loss of DNA binding and loss of transactivation activity; loss of small and large myelinated nerve fibers; residual fibers with thin myelin sheaths. 4 PublicationsCorresponds to variant dbSNP:rs104894161EnsemblClinVar. | 1 | |
Natural variantiVAR_083344 | 411 | D → G in DSS. 1 Publication | 1 | |
Natural variantiVAR_083346 | 412 | E → K in DSS; loss of DNA binding and loss of transactivation activity. 1 PublicationCorresponds to variant dbSNP:rs121434563EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 162 – 165 | DHLY → AAAA: Inhibits association with HCFC1. 1 Publication | 4 |
Keywords - Diseasei
Charcot-Marie-Tooth disease, Dejerine-Sottas syndrome, Disease variant, Neurodegeneration, NeuropathyOrganism-specific databases
DisGeNETi | 1959 |
GeneReviewsi | EGR2 |
MalaCardsi | EGR2 |
MIMi | 145900, phenotype 605253, phenotype 607678, phenotype |
OpenTargetsi | ENSG00000122877 |
Orphaneti | 101084, Charcot-Marie-Tooth disease type 1D 99951, Charcot-Marie-Tooth disease type 4E 64748, Dejerine-Sottas syndrome |
PharmGKBi | PA27674 |
Miscellaneous databases
Pharosi | P11161, Tbio |
Genetic variation databases
BioMutai | EGR2 |
DMDMi | 33112654 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047119 | 1 – 476 | E3 SUMO-protein ligase EGR2Add BLAST | 476 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 247 | N6-acetyllysine; by EP300By similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Ubl conjugationProteomic databases
jPOSTi | P11161 |
MassIVEi | P11161 |
PaxDbi | P11161 |
PeptideAtlasi | P11161 |
PRIDEi | P11161 |
ProteomicsDBi | 52701 [P11161-1] 52702 [P11161-2] |
PTM databases
GlyGeni | P11161, 13 sites, 2 O-linked glycans (13 sites) |
iPTMneti | P11161 |
PhosphoSitePlusi | P11161 |
Expressioni
Gene expression databases
Bgeei | ENSG00000122877, Expressed in thyroid gland and 119 other tissues |
ExpressionAtlasi | P11161, baseline and differential |
Organism-specific databases
HPAi | ENSG00000122877, Tissue enhanced (epididymis, thyroid gland) |
Interactioni
Subunit structurei
Binary interactionsi
P11161
With | #Exp. | IntAct |
---|---|---|
YAP1 [P46937] | 2 | EBI-625282,EBI-1044059 |
GO - Molecular functioni
- HMG box domain binding Source: Ensembl
- RNA polymerase II-specific DNA-binding transcription factor binding Source: BHF-UCL
- ubiquitin protein ligase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 108279, 22 interactors |
IntActi | P11161, 14 interactors |
MINTi | P11161 |
STRINGi | 9606.ENSP00000242480 |
Miscellaneous databases
RNActi | P11161, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 127 – 178 | DisorderedSequence analysisAdd BLAST | 52 | |
Regioni | 275 – 300 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 318 – 341 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 412 – 476 | DisorderedSequence analysisAdd BLAST | 65 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 162 – 165 | HCFC1-binding-motif (HBM) | 4 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 127 – 162 | Polar residuesSequence analysisAdd BLAST | 36 | |
Compositional biasi | 428 – 476 | Polar residuesSequence analysisAdd BLAST | 49 |
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 340 – 364 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 370 – 392 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 398 – 420 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000158394 |
HOGENOMi | CLU_043235_0_0_1 |
InParanoidi | P11161 |
OMAi | PQCQREL |
OrthoDBi | 1621899at2759 |
PhylomeDBi | P11161 |
TreeFami | TF318980 |
Family and domain databases
InterProi | View protein in InterPro IPR021849, EGR_N IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF11928, DUF3446, 1 hit PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MMTAKAVDKI PVTLSGFVHQ LSDNIYPVED LAATSVTIFP NAELGGPFDQ
60 70 80 90 100
MNGVAGDGMI NIDMTGEKRS LDLPYPSSFA PVSAPRNQTF TYMGKFSIDP
110 120 130 140 150
QYPGASCYPE GIINIVSAGI LQGVTSPAST TASSSVTSAS PNPLATGPLG
160 170 180 190 200
VCTMSQTQPD LDHLYSPPPP PPPYSGCAGD LYQDPSAFLS AATTSTSSSL
210 220 230 240 250
AYPPPPSYPS PKPATDPGLF PMIPDYPGFF PSQCQRDLHG TAGPDRKPFP
260 270 280 290 300
CPLDTLRVPP PLTPLSTIRN FTLGGPSAGV TGPGASGGSE GPRLPGSSSA
310 320 330 340 350
AAAAAAAAAY NPHHLPLRPI LRPRKYPNRP SKTPVHERPY PCPAEGCDRR
360 370 380 390 400
FSRSDELTRH IRIHTGHKPF QCRICMRNFS RSDHLTTHIR THTGEKPFAC
410 420 430 440 450
DYCGRKFARS DERKRHTKIH LRQKERKSSA PSASVPAPST ASCSGGVQPG
460 470
GTLCSSNSSS LGGGPLAPCS SRTRTP
The sequence of this isoform differs from the canonical sequence as follows:
1-50: Missing.
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1B0GUL0 | A0A1B0GUL0_HUMAN | E3 SUMO-protein ligase EGR2 | EGR2 | 139 | Annotation score: | ||
A0A8I5KVU0 | A0A8I5KVU0_HUMAN | E3 SUMO-protein ligase EGR2 | EGR2 | 174 | Annotation score: | ||
A0A8I5KYI5 | A0A8I5KYI5_HUMAN | E3 SUMO-protein ligase EGR2 | EGR2 | 489 | Annotation score: | ||
A0A8I5QL03 | A0A8I5QL03_HUMAN | E3 SUMO-protein ligase EGR2 | EGR2 | 68 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 68 | K → R in CAH18435 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 247 | K → KPFPCPLDTLRVPPPLTPLS TIRK in AAH35625 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 280 | V → M in AAA52372 (PubMed:3140236).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_007735 | 268 | I → N in CHN1; loss of large and small myelinated nerve fibers. 2 PublicationsCorresponds to variant dbSNP:rs104894158EnsemblClinVar. | 1 | |
Natural variantiVAR_007736 | 355 | D → V in CMT1D. 2 PublicationsCorresponds to variant dbSNP:rs1589080611EnsemblClinVar. | 1 | |
Natural variantiVAR_009874 | 359 | R → W in DSS and CMT1D; associated with A-136 in the GJB1 gene in a DSS Korean girl; loss of DNA binding and loss of transactivation activity; loss of small and large myelinated nerve fibers; residual fibers with thin myelin sheaths. 4 PublicationsCorresponds to variant dbSNP:rs104894161EnsemblClinVar. | 1 | |
Natural variantiVAR_029958 | 381 | R → C in CMT1D. 1 PublicationCorresponds to variant dbSNP:rs1589080524EnsemblClinVar. | 1 | |
Natural variantiVAR_009875 | 381 | R → H in CMT1D. 1 PublicationCorresponds to variant dbSNP:rs281865137EnsemblClinVar. | 1 | |
Natural variantiVAR_007737 | 382 – 383 | SD → RY in CHN1. | 2 | |
Natural variantiVAR_029959 | 383 | D → Y in CMT1D. 1 PublicationCorresponds to variant dbSNP:rs104894160EnsemblClinVar. | 1 | |
Natural variantiVAR_083343 | 387 | T → N in CMT1D; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs281865139EnsemblClinVar. | 1 | |
Natural variantiVAR_007738 | 409 | R → W in CMT1D. 1 PublicationCorresponds to variant dbSNP:rs104894159EnsemblClinVar. | 1 | |
Natural variantiVAR_083344 | 411 | D → G in DSS. 1 Publication | 1 | |
Natural variantiVAR_083345 | 412 | E → G in CMT1D; loss of myelinated and unmyelinated nerve fibers. 2 PublicationsCorresponds to variant dbSNP:rs749558026EnsemblClinVar. | 1 | |
Natural variantiVAR_083346 | 412 | E → K in DSS; loss of DNA binding and loss of transactivation activity. 1 PublicationCorresponds to variant dbSNP:rs121434563EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_006863 | 1 – 50 | Missing in isoform Short. 1 PublicationAdd BLAST | 50 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J04076 mRNA Translation: AAA52372.1 Sequence problems. AF139463 mRNA Translation: AAD24588.1 AK091399 mRNA Translation: BAG52349.1 AK312813 mRNA Translation: BAG35671.1 CR749641 mRNA Translation: CAH18435.1 AL133417 Genomic DNA No translation available. CH471083 Genomic DNA Translation: EAW54238.1 CH471083 Genomic DNA Translation: EAW54239.1 BC035625 mRNA Translation: AAH35625.1 X53700 Genomic DNA No translation available. |
CCDSi | CCDS44409.1 [P11161-2] CCDS7267.1 [P11161-1] |
RefSeqi | NP_000390.2, NM_000399.4 [P11161-1] NP_001129649.1, NM_001136177.2 [P11161-1] NP_001129650.1, NM_001136178.1 [P11161-1] NP_001129651.1, NM_001136179.2 [P11161-2] NP_001307966.1, NM_001321037.1 [P11161-2] |
Genome annotation databases
Ensembli | ENST00000242480.4; ENSP00000242480.3; ENSG00000122877.18 ENST00000411732.4; ENSP00000387634.1; ENSG00000122877.18 [P11161-2] ENST00000637191.2; ENSP00000490154.2; ENSG00000122877.18 |
GeneIDi | 1959 |
KEGGi | hsa:1959 |
MANE-Selecti | ENST00000242480.4; ENSP00000242480.3; NM_000399.5; NP_000390.2 |
UCSCi | uc001jmi.4, human [P11161-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Inherited peripheral neuropathies mutation db |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J04076 mRNA Translation: AAA52372.1 Sequence problems. AF139463 mRNA Translation: AAD24588.1 AK091399 mRNA Translation: BAG52349.1 AK312813 mRNA Translation: BAG35671.1 CR749641 mRNA Translation: CAH18435.1 AL133417 Genomic DNA No translation available. CH471083 Genomic DNA Translation: EAW54238.1 CH471083 Genomic DNA Translation: EAW54239.1 BC035625 mRNA Translation: AAH35625.1 X53700 Genomic DNA No translation available. |
CCDSi | CCDS44409.1 [P11161-2] CCDS7267.1 [P11161-1] |
RefSeqi | NP_000390.2, NM_000399.4 [P11161-1] NP_001129649.1, NM_001136177.2 [P11161-1] NP_001129650.1, NM_001136178.1 [P11161-1] NP_001129651.1, NM_001136179.2 [P11161-2] NP_001307966.1, NM_001321037.1 [P11161-2] |
3D structure databases
AlphaFoldDBi | P11161 |
SMRi | P11161 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 108279, 22 interactors |
IntActi | P11161, 14 interactors |
MINTi | P11161 |
STRINGi | 9606.ENSP00000242480 |
PTM databases
GlyGeni | P11161, 13 sites, 2 O-linked glycans (13 sites) |
iPTMneti | P11161 |
PhosphoSitePlusi | P11161 |
Genetic variation databases
BioMutai | EGR2 |
DMDMi | 33112654 |
Proteomic databases
jPOSTi | P11161 |
MassIVEi | P11161 |
PaxDbi | P11161 |
PeptideAtlasi | P11161 |
PRIDEi | P11161 |
ProteomicsDBi | 52701 [P11161-1] 52702 [P11161-2] |
Protocols and materials databases
Antibodypediai | 14464, 506 antibodies from 43 providers |
DNASUi | 1959 |
Genome annotation databases
Ensembli | ENST00000242480.4; ENSP00000242480.3; ENSG00000122877.18 ENST00000411732.4; ENSP00000387634.1; ENSG00000122877.18 [P11161-2] ENST00000637191.2; ENSP00000490154.2; ENSG00000122877.18 |
GeneIDi | 1959 |
KEGGi | hsa:1959 |
MANE-Selecti | ENST00000242480.4; ENSP00000242480.3; NM_000399.5; NP_000390.2 |
UCSCi | uc001jmi.4, human [P11161-1] |
Organism-specific databases
CTDi | 1959 |
DisGeNETi | 1959 |
GeneCardsi | EGR2 |
GeneReviewsi | EGR2 |
HGNCi | HGNC:3239, EGR2 |
HPAi | ENSG00000122877, Tissue enhanced (epididymis, thyroid gland) |
MalaCardsi | EGR2 |
MIMi | 129010, gene 145900, phenotype 605253, phenotype 607678, phenotype |
neXtProti | NX_P11161 |
OpenTargetsi | ENSG00000122877 |
Orphaneti | 101084, Charcot-Marie-Tooth disease type 1D 99951, Charcot-Marie-Tooth disease type 4E 64748, Dejerine-Sottas syndrome |
PharmGKBi | PA27674 |
VEuPathDBi | HostDB:ENSG00000122877 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000158394 |
HOGENOMi | CLU_043235_0_0_1 |
InParanoidi | P11161 |
OMAi | PQCQREL |
OrthoDBi | 1621899at2759 |
PhylomeDBi | P11161 |
TreeFami | TF318980 |
Enzyme and pathway databases
UniPathwayi | UPA00886 |
PathwayCommonsi | P11161 |
Reactomei | R-HSA-381340, Transcriptional regulation of white adipocyte differentiation R-HSA-5617472, Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-9031628, NGF-stimulated transcription R-HSA-9619665, EGR2 and SOX10-mediated initiation of Schwann cell myelination |
SignaLinki | P11161 |
SIGNORi | P11161 |
Miscellaneous databases
BioGRID-ORCSi | 1959, 229 hits in 1088 CRISPR screens |
GeneWikii | EGR2 |
GenomeRNAii | 1959 |
Pharosi | P11161, Tbio |
PROi | PR:P11161 |
RNActi | P11161, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000122877, Expressed in thyroid gland and 119 other tissues |
ExpressionAtlasi | P11161, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR021849, EGR_N IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF11928, DUF3446, 1 hit PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | EGR2_HUMAN | |
Accessioni | P11161Primary (citable) accession number: P11161 Secondary accession number(s): B2R724 Q9UNA6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | July 19, 2003 | |
Last modified: | May 25, 2022 | |
This is version 221 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families