Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Hepatic triacylglycerol lipase

Gene

LIPC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei168NucleophileBy similarity1
Active sitei194Charge relay systemPROSITE-ProRule annotation1
Active sitei279Charge relay systemPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • apolipoprotein binding Source: BHF-UCL
  • heparin binding Source: UniProtKB-KW
  • low-density lipoprotein particle binding Source: BHF-UCL
  • phospholipase activity Source: BHF-UCL
  • triglyceride lipase activity Source: BHF-UCL

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHeparin-binding, Hydrolase
Biological processLipid degradation, Lipid metabolism

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8963889 Assembly of active LPL and LIPC lipase complexes
R-HSA-8964026 Chylomicron clearance

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

More...
ESTHERi
human-LIPC Hepatic_Lipase

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000000569

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Hepatic triacylglycerol lipase (EC:3.1.1.3)
Short name:
HL
Short name:
Hepatic lipase
Alternative name(s):
Lipase member C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LIPC
Synonyms:HTGL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000166035.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6619 LIPC

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
151670 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P11150

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

HDL, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Hepatic lipase deficiency (HL deficiency)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by elevated levels of beta-migrating very low density lipoproteins, and abnormally triglyceride-rich low and high density lipoproteins.
See also OMIM:614025
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_004207134V → VHYTVAV in HL deficiency. 1 Publication1
Natural variantiVAR_004209289S → F in HL deficiency. 2 PublicationsCorresponds to variant dbSNP:rs121912502EnsemblClinVar.1
Natural variantiVAR_004210405T → M in HL deficiency. 2 PublicationsCorresponds to variant dbSNP:rs113298164EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
3990

MalaCards human disease database

More...
MalaCardsi
LIPC
MIMi125853 phenotype
612797 phenotype
614025 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000166035

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
140905 Hyperlipidemia due to hepatic triacylglycerol lipase deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA230

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2127

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LIPC

Domain mapping of disease mutations (DMDM)

More...
DMDMi
317373430

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Add BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001776923 – 499Hepatic triacylglycerol lipaseAdd BLAST477

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi42N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi78N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi362N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi397N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P11150

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P11150

PeptideAtlas

More...
PeptideAtlasi
P11150

PRoteomics IDEntifications database

More...
PRIDEi
P11150

ProteomicsDB human proteome resource

More...
ProteomicsDBi
52700

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P11150

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P11150

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000166035 Expressed in 87 organ(s), highest expression level in liver

CleanEx database of gene expression profiles

More...
CleanExi
HS_LIPC

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P11150 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P11150 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110178, 7 interactors

Protein interaction database and analysis system

More...
IntActi
P11150, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000299022

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P11150

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P11150

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini352 – 486PLATPROSITE-ProRule annotationAdd BLAST135

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni181 – 193Heparin-bindingSequence analysisAdd BLAST13

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IIHP Eukaryota
ENOG4110MCZ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157602

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000038553

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG002259

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P11150

KEGG Orthology (KO)

More...
KOi
K22283

Database of Orthologous Groups

More...
OrthoDBi
534956at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P11150

TreeFam database of animal gene trees

More...
TreeFami
TF324997

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00707 Pancreat_lipase_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.1820, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029058 AB_hydrolase
IPR013818 Lipase/vitellogenin
IPR002333 Lipase_hep
IPR016272 Lipase_LIPH
IPR033906 Lipase_N
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
IPR000734 TAG_lipase

The PANTHER Classification System

More...
PANTHERi
PTHR11610 PTHR11610, 1 hit
PTHR11610:SF2 PTHR11610:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00151 Lipase, 1 hit
PF01477 PLAT, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000865 Lipoprotein_lipase_LIPH, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00824 HEPLIPASE
PR00821 TAGLIPASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00308 LH2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49723 SSF49723, 1 hit
SSF53474 SSF53474, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00120 LIPASE_SER, 1 hit
PS50095 PLAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P11150-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDTSPLCFSI LLVLCIFIQS SALGQSLKPE PFGRRAQAVE TNKTLHEMKT
60 70 80 90 100
RFLLFGETNQ GCQIRINHPD TLQECGFNSS LPLVMIIHGW SVDGVLENWI
110 120 130 140 150
WQMVAALKSQ PAQPVNVGLV DWITLAHDHY TIAVRNTRLV GKEVAALLRW
160 170 180 190 200
LEESVQLSRS HVHLIGYSLG AHVSGFAGSS IGGTHKIGRI TGLDAAGPLF
210 220 230 240 250
EGSAPSNRLS PDDANFVDAI HTFTREHMGL SVGIKQPIGH YDFYPNGGSF
260 270 280 290 300
QPGCHFLELY RHIAQHGFNA ITQTIKCSHE RSVHLFIDSL LHAGTQSMAY
310 320 330 340 350
PCGDMNSFSQ GLCLSCKKGR CNTLGYHVRQ EPRSKSKRLF LVTRAQSPFK
360 370 380 390 400
VYHYQFKIQF INQTETPIQT TFTMSLLGTK EKMQKIPITL GKGIASNKTY
410 420 430 440 450
SFLITLDVDI GELIMIKFKW ENSAVWANVW DTVQTIIPWS TGPRHSGLVL
460 470 480 490
KTIRVKAGET QQRMTFCSEN TDDLLLRPTQ EKIFVKCEIK SKTSKRKIR
Length:499
Mass (Da):55,914
Last modified:January 11, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1FC7567CAE3E514B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EUJ1E7EUJ1_HUMAN
Hepatic triacylglycerol lipase
LIPC
499Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EUK6E7EUK6_HUMAN
Hepatic triacylglycerol lipase
LIPC
438Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti256F → S in AAA61165 (PubMed:2828141).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Genetic variations in LIPC define the high density lipoprotein cholesterol level quantitative trait locus 12 (HDLCQ12) [MIMi:612797].1 Publication
Genetic variations in LIPC are associated with non-insulin-dependent diabetes mellitus susceptibility (NIDDM susceptibility) [MIMi:125853].1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00420695V → M2 PublicationsCorresponds to variant dbSNP:rs6078EnsemblClinVar.1
Natural variantiVAR_004207134V → VHYTVAV in HL deficiency. 1 Publication1
Natural variantiVAR_004208215N → S6 PublicationsCorresponds to variant dbSNP:rs6083EnsemblClinVar.1
Natural variantiVAR_004209289S → F in HL deficiency. 2 PublicationsCorresponds to variant dbSNP:rs121912502EnsemblClinVar.1
Natural variantiVAR_017024342V → I1 PublicationCorresponds to variant dbSNP:rs145811475Ensembl.1
Natural variantiVAR_017025356F → L8 PublicationsCorresponds to variant dbSNP:rs3829462EnsemblClinVar.1
Natural variantiVAR_004210405T → M in HL deficiency. 2 PublicationsCorresponds to variant dbSNP:rs113298164EnsemblClinVar.1
Natural variantiVAR_017026409D → A1 PublicationCorresponds to variant dbSNP:rs142036980Ensembl.1
Natural variantiVAR_014179440S → N1 PublicationCorresponds to variant dbSNP:rs6079Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D83548 mRNA Translation: BAA12014.1
X07228 mRNA Translation: CAA30188.1
J03540 mRNA Translation: AAA59520.1
J03895 mRNA Translation: AAA61165.1
M29194
, M29186, M29187, M29188, M29189, M29190, M29191, M29192, M29193 Genomic DNA Translation: AAB60702.1
D83062 Genomic DNA Translation: BAA11760.1
M35433
, M35425, M35426, M35427, M35429, M35430, M35431, M35432 Genomic DNA Translation: AAA59521.1
AK292631 mRNA Translation: BAF85320.1
AK315306 mRNA Translation: BAG37710.1
AC018904 Genomic DNA No translation available.
AC084781 Genomic DNA No translation available.
BC132825 mRNA Translation: AAI32826.1
BC136495 mRNA Translation: AAI36496.1
AF037404 Genomic DNA Translation: AAC34206.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10166.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A28997

NCBI Reference Sequences

More...
RefSeqi
NP_000227.2, NM_000236.2
XP_005254429.1, XM_005254372.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.654472

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000299022; ENSP00000299022; ENSG00000166035
ENST00000356113; ENSP00000348425; ENSG00000166035

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3990

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3990

UCSC genome browser

More...
UCSCi
uc002afa.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83548 mRNA Translation: BAA12014.1
X07228 mRNA Translation: CAA30188.1
J03540 mRNA Translation: AAA59520.1
J03895 mRNA Translation: AAA61165.1
M29194
, M29186, M29187, M29188, M29189, M29190, M29191, M29192, M29193 Genomic DNA Translation: AAB60702.1
D83062 Genomic DNA Translation: BAA11760.1
M35433
, M35425, M35426, M35427, M35429, M35430, M35431, M35432 Genomic DNA Translation: AAA59521.1
AK292631 mRNA Translation: BAF85320.1
AK315306 mRNA Translation: BAG37710.1
AC018904 Genomic DNA No translation available.
AC084781 Genomic DNA No translation available.
BC132825 mRNA Translation: AAI32826.1
BC136495 mRNA Translation: AAI36496.1
AF037404 Genomic DNA Translation: AAC34206.1
CCDSiCCDS10166.1
PIRiA28997
RefSeqiNP_000227.2, NM_000236.2
XP_005254429.1, XM_005254372.1
UniGeneiHs.654472

3D structure databases

ProteinModelPortaliP11150
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110178, 7 interactors
IntActiP11150, 1 interactor
STRINGi9606.ENSP00000299022

Chemistry databases

BindingDBiP11150
ChEMBLiCHEMBL2127
SwissLipidsiSLP:000000569

Protein family/group databases

ESTHERihuman-LIPC Hepatic_Lipase

PTM databases

iPTMnetiP11150
PhosphoSitePlusiP11150

Polymorphism and mutation databases

BioMutaiLIPC
DMDMi317373430

Proteomic databases

jPOSTiP11150
PaxDbiP11150
PeptideAtlasiP11150
PRIDEiP11150
ProteomicsDBi52700

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3990
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299022; ENSP00000299022; ENSG00000166035
ENST00000356113; ENSP00000348425; ENSG00000166035
GeneIDi3990
KEGGihsa:3990
UCSCiuc002afa.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3990
DisGeNETi3990
EuPathDBiHostDB:ENSG00000166035.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LIPC

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0038150
HGNCiHGNC:6619 LIPC
MalaCardsiLIPC
MIMi125853 phenotype
151670 gene
612797 phenotype
614025 phenotype
neXtProtiNX_P11150
OpenTargetsiENSG00000166035
Orphaneti140905 Hyperlipidemia due to hepatic triacylglycerol lipase deficiency
PharmGKBiPA230

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IIHP Eukaryota
ENOG4110MCZ LUCA
GeneTreeiENSGT00940000157602
HOGENOMiHOG000038553
HOVERGENiHBG002259
InParanoidiP11150
KOiK22283
OrthoDBi534956at2759
PhylomeDBiP11150
TreeFamiTF324997

Enzyme and pathway databases

ReactomeiR-HSA-8963889 Assembly of active LPL and LIPC lipase complexes
R-HSA-8964026 Chylomicron clearance

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
LIPC human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Hepatic_lipase

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3990

Protein Ontology

More...
PROi
PR:P11150

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000166035 Expressed in 87 organ(s), highest expression level in liver
CleanExiHS_LIPC
ExpressionAtlasiP11150 baseline and differential
GenevisibleiP11150 HS

Family and domain databases

CDDicd00707 Pancreat_lipase_like, 1 hit
Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR013818 Lipase/vitellogenin
IPR002333 Lipase_hep
IPR016272 Lipase_LIPH
IPR033906 Lipase_N
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
IPR000734 TAG_lipase
PANTHERiPTHR11610 PTHR11610, 1 hit
PTHR11610:SF2 PTHR11610:SF2, 1 hit
PfamiView protein in Pfam
PF00151 Lipase, 1 hit
PF01477 PLAT, 1 hit
PIRSFiPIRSF000865 Lipoprotein_lipase_LIPH, 1 hit
PRINTSiPR00824 HEPLIPASE
PR00821 TAGLIPASE
SMARTiView protein in SMART
SM00308 LH2, 1 hit
SUPFAMiSSF49723 SSF49723, 1 hit
SSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00120 LIPASE_SER, 1 hit
PS50095 PLAT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLIPC_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P11150
Secondary accession number(s): A2RUB4
, A8K9B6, O43571, P78529, Q99465
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 11, 2011
Last modified: January 16, 2019
This is version 201 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again