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Protein

Hepatic triacylglycerol lipase

Gene

LIPC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin.

Catalytic activityi

Triacylglycerol + H2O = diacylglycerol + a carboxylate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei168NucleophileBy similarity1
Active sitei194Charge relay systemPROSITE-ProRule annotation1
Active sitei279Charge relay systemPROSITE-ProRule annotation1

GO - Molecular functioni

  • apolipoprotein binding Source: BHF-UCL
  • heparin binding Source: UniProtKB-KW
  • low-density lipoprotein particle binding Source: BHF-UCL
  • phospholipase activity Source: BHF-UCL
  • triglyceride lipase activity Source: BHF-UCL

GO - Biological processi

  • cholesterol homeostasis Source: BHF-UCL
  • cholesterol metabolic process Source: Ensembl
  • chylomicron remnant clearance Source: BHF-UCL
  • fatty acid biosynthetic process Source: BHF-UCL
  • high-density lipoprotein particle remodeling Source: BHF-UCL
  • intermediate-density lipoprotein particle remodeling Source: BHF-UCL
  • low-density lipoprotein particle remodeling Source: BHF-UCL
  • phosphatidylcholine catabolic process Source: BHF-UCL
  • regulation of lipoprotein lipase activity Source: Reactome
  • reverse cholesterol transport Source: BHF-UCL
  • triglyceride catabolic process Source: BHF-UCL
  • triglyceride homeostasis Source: BHF-UCL
  • very-low-density lipoprotein particle remodeling Source: BHF-UCL

Keywordsi

Molecular functionHeparin-binding, Hydrolase
Biological processLipid degradation, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-HSA-8963889 Assembly of active LPL and LIPC lipase complexes
R-HSA-8964026 Chylomicron clearance

Protein family/group databases

ESTHERihuman-LIPC Hepatic_Lipase

Chemistry databases

SwissLipidsiSLP:000000569

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatic triacylglycerol lipase (EC:3.1.1.3)
Short name:
HL
Short name:
Hepatic lipase
Alternative name(s):
Lipase member C
Gene namesi
Name:LIPC
Synonyms:HTGL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000166035.10
HGNCiHGNC:6619 LIPC
MIMi151670 gene
neXtProtiNX_P11150

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

HDL, Secreted

Pathology & Biotechi

Involvement in diseasei

Hepatic lipase deficiency (HL deficiency)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by elevated levels of beta-migrating very low density lipoproteins, and abnormally triglyceride-rich low and high density lipoproteins.
See also OMIM:614025
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_004207134V → VHYTVAV in HL deficiency. 1 Publication1
Natural variantiVAR_004209289S → F in HL deficiency. 2 PublicationsCorresponds to variant dbSNP:rs121912502EnsemblClinVar.1
Natural variantiVAR_004210405T → M in HL deficiency. 2 PublicationsCorresponds to variant dbSNP:rs113298164EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi3990
MalaCardsiLIPC
MIMi125853 phenotype
612797 phenotype
614025 phenotype
OpenTargetsiENSG00000166035
Orphaneti140905 Hyperlipidemia due to hepatic triglyceride lipase deficiency
PharmGKBiPA230

Chemistry databases

ChEMBLiCHEMBL2127

Polymorphism and mutation databases

BioMutaiLIPC
DMDMi317373430

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Add BLAST22
ChainiPRO_000001776923 – 499Hepatic triacylglycerol lipaseAdd BLAST477

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi42N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi78N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi362N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi397N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP11150
PeptideAtlasiP11150
PRIDEiP11150
ProteomicsDBi52700

PTM databases

iPTMnetiP11150
PhosphoSitePlusiP11150

Expressioni

Gene expression databases

BgeeiENSG00000166035
CleanExiHS_LIPC
ExpressionAtlasiP11150 baseline and differential
GenevisibleiP11150 HS

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110178, 7 interactors
IntActiP11150, 1 interactor
STRINGi9606.ENSP00000299022

Chemistry databases

BindingDBiP11150

Structurei

3D structure databases

ProteinModelPortaliP11150
SMRiP11150
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini352 – 486PLATPROSITE-ProRule annotationAdd BLAST135

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni181 – 193Heparin-bindingSequence analysisAdd BLAST13

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIHP Eukaryota
ENOG4110MCZ LUCA
GeneTreeiENSGT00760000119069
HOGENOMiHOG000038553
HOVERGENiHBG002259
InParanoidiP11150
KOiK22283
OrthoDBiEOG091G052B
PhylomeDBiP11150
TreeFamiTF324997

Family and domain databases

CDDicd00707 Pancreat_lipase_like, 1 hit
Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR013818 Lipase/vitellogenin
IPR002333 Lipase_hep
IPR016272 Lipase_LIPH
IPR033906 Lipase_N
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
IPR000734 TAG_lipase
PANTHERiPTHR11610 PTHR11610, 1 hit
PTHR11610:SF2 PTHR11610:SF2, 1 hit
PfamiView protein in Pfam
PF00151 Lipase, 1 hit
PF01477 PLAT, 1 hit
PIRSFiPIRSF000865 Lipoprotein_lipase_LIPH, 1 hit
PRINTSiPR00824 HEPLIPASE
PR00821 TAGLIPASE
SMARTiView protein in SMART
SM00308 LH2, 1 hit
SUPFAMiSSF49723 SSF49723, 1 hit
SSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00120 LIPASE_SER, 1 hit
PS50095 PLAT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P11150-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTSPLCFSI LLVLCIFIQS SALGQSLKPE PFGRRAQAVE TNKTLHEMKT
60 70 80 90 100
RFLLFGETNQ GCQIRINHPD TLQECGFNSS LPLVMIIHGW SVDGVLENWI
110 120 130 140 150
WQMVAALKSQ PAQPVNVGLV DWITLAHDHY TIAVRNTRLV GKEVAALLRW
160 170 180 190 200
LEESVQLSRS HVHLIGYSLG AHVSGFAGSS IGGTHKIGRI TGLDAAGPLF
210 220 230 240 250
EGSAPSNRLS PDDANFVDAI HTFTREHMGL SVGIKQPIGH YDFYPNGGSF
260 270 280 290 300
QPGCHFLELY RHIAQHGFNA ITQTIKCSHE RSVHLFIDSL LHAGTQSMAY
310 320 330 340 350
PCGDMNSFSQ GLCLSCKKGR CNTLGYHVRQ EPRSKSKRLF LVTRAQSPFK
360 370 380 390 400
VYHYQFKIQF INQTETPIQT TFTMSLLGTK EKMQKIPITL GKGIASNKTY
410 420 430 440 450
SFLITLDVDI GELIMIKFKW ENSAVWANVW DTVQTIIPWS TGPRHSGLVL
460 470 480 490
KTIRVKAGET QQRMTFCSEN TDDLLLRPTQ EKIFVKCEIK SKTSKRKIR
Length:499
Mass (Da):55,914
Last modified:January 11, 2011 - v3
Checksum:i1FC7567CAE3E514B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti256F → S in AAA61165 (PubMed:2828141).Curated1

Polymorphismi

Genetic variations in LIPC define the high density lipoprotein cholesterol level quantitative trait locus 12 (HDLCQ12) [MIMi:612797].1 Publication
Genetic variations in LIPC are associated with non-insulin-dependent diabetes mellitus susceptibility (NIDDM susceptibility) [MIMi:125853].1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00420695V → M2 PublicationsCorresponds to variant dbSNP:rs6078EnsemblClinVar.1
Natural variantiVAR_004207134V → VHYTVAV in HL deficiency. 1 Publication1
Natural variantiVAR_004208215N → S6 PublicationsCorresponds to variant dbSNP:rs6083EnsemblClinVar.1
Natural variantiVAR_004209289S → F in HL deficiency. 2 PublicationsCorresponds to variant dbSNP:rs121912502EnsemblClinVar.1
Natural variantiVAR_017024342V → I1 PublicationCorresponds to variant dbSNP:rs145811475Ensembl.1
Natural variantiVAR_017025356F → L8 PublicationsCorresponds to variant dbSNP:rs3829462EnsemblClinVar.1
Natural variantiVAR_004210405T → M in HL deficiency. 2 PublicationsCorresponds to variant dbSNP:rs113298164EnsemblClinVar.1
Natural variantiVAR_017026409D → A1 PublicationCorresponds to variant dbSNP:rs142036980Ensembl.1
Natural variantiVAR_014179440S → N1 PublicationCorresponds to variant dbSNP:rs6079Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83548 mRNA Translation: BAA12014.1
X07228 mRNA Translation: CAA30188.1
J03540 mRNA Translation: AAA59520.1
J03895 mRNA Translation: AAA61165.1
M29194
, M29186, M29187, M29188, M29189, M29190, M29191, M29192, M29193 Genomic DNA Translation: AAB60702.1
D83062 Genomic DNA Translation: BAA11760.1
M35433
, M35425, M35426, M35427, M35429, M35430, M35431, M35432 Genomic DNA Translation: AAA59521.1
AK292631 mRNA Translation: BAF85320.1
AK315306 mRNA Translation: BAG37710.1
AC018904 Genomic DNA No translation available.
AC084781 Genomic DNA No translation available.
BC132825 mRNA Translation: AAI32826.1
BC136495 mRNA Translation: AAI36496.1
AF037404 Genomic DNA Translation: AAC34206.1
CCDSiCCDS10166.1
PIRiA28997
RefSeqiNP_000227.2, NM_000236.2
XP_005254429.1, XM_005254372.1
UniGeneiHs.654472

Genome annotation databases

EnsembliENST00000299022; ENSP00000299022; ENSG00000166035
ENST00000356113; ENSP00000348425; ENSG00000166035
GeneIDi3990
KEGGihsa:3990
UCSCiuc002afa.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLIPC_HUMAN
AccessioniPrimary (citable) accession number: P11150
Secondary accession number(s): A2RUB4
, A8K9B6, O43571, P78529, Q99465
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 11, 2011
Last modified: June 20, 2018
This is version 196 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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