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Protein

Heat shock 70 kDa protein cognate 4

Gene

Hsc70-4

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • chaperone binding Source: FlyBase
  • unfolded protein binding Source: FlyBase

GO - Biological processi

  • axonal fasciculation Source: FlyBase
  • axon guidance Source: FlyBase
  • cellular response to topologically incorrect protein Source: FlyBase
  • chaperone-mediated protein folding Source: FlyBase
  • embryonic development via the syncytial blastoderm Source: FlyBase
  • heterochromatin organization involved in chromatin silencing Source: FlyBase
  • late endosomal microautophagy Source: FlyBase
  • membrane organization Source: FlyBase
  • mRNA splicing, via spliceosome Source: FlyBase
  • nervous system development Source: FlyBase
  • neurotransmitter secretion Source: FlyBase
  • ovarian follicle cell development Source: FlyBase
  • protein folding Source: FlyBase
  • RNA interference Source: FlyBase
  • vesicle-mediated transport Source: FlyBase

Keywordsi

Biological processStress response
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-3371453 Regulation of HSF1-mediated heat shock response
R-DME-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-DME-3371568 Attenuation phase
R-DME-3371571 HSF1-dependent transactivation
R-DME-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-DME-6798695 Neutrophil degranulation
R-DME-72163 mRNA Splicing - Major Pathway
R-DME-8856828 Clathrin-mediated endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock 70 kDa protein cognate 4
Alternative name(s):
Heat shock 70 kDa protein 88E
Gene namesi
Name:Hsc70-4
Synonyms:Hsc4
ORF Names:CG4264
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0266599 Hsc70-4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000783401 – 651Heat shock 70 kDa protein cognate 4Add BLAST651

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi35N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP11147
PRIDEiP11147

PTM databases

iPTMnetiP11147

Expressioni

Developmental stagei

Heat shock cognate proteins are expressed constitutively during normal development.

Gene expression databases

BgeeiFBgn0266599
ExpressionAtlasiP11147 baseline and differential
GenevisibleiP11147 DM

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
stumpsO967573EBI-75181,EBI-74922

GO - Molecular functioni

  • chaperone binding Source: FlyBase
  • unfolded protein binding Source: FlyBase

Protein-protein interaction databases

BioGridi66904, 78 interactors
DIPiDIP-19158N
IntActiP11147, 44 interactors
MINTiP11147
STRINGi7227.FBpp0082516

Structurei

3D structure databases

ProteinModelPortaliP11147
SMRiP11147
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiKOG0101 Eukaryota
COG0443 LUCA
GeneTreeiENSGT00910000144045
InParanoidiP11147
KOiK03283
OMAiIANPIMT
OrthoDBiEOG091G03SF
PhylomeDBiP11147

Family and domain databases

Gene3Di1.20.1270.10, 1 hit
2.60.34.10, 1 hit
InterProiView protein in InterPro
IPR018181 Heat_shock_70_CS
IPR029048 HSP70_C_sf
IPR029047 HSP70_peptide-bd_sf
IPR013126 Hsp_70_fam
PANTHERiPTHR19375 PTHR19375, 1 hit
PfamiView protein in Pfam
PF00012 HSP70, 1 hit
PRINTSiPR00301 HEATSHOCK70
SUPFAMiSSF100920 SSF100920, 1 hit
SSF100934 SSF100934, 1 hit
PROSITEiView protein in PROSITE
PS00297 HSP70_1, 1 hit
PS00329 HSP70_2, 1 hit
PS01036 HSP70_3, 1 hit

Sequencei

Sequence statusi: Complete.

P11147-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKAPAVGID LGTTYSCVGV FQHGKVEIIA NDQGNRTTPS YVAFTDTERL
60 70 80 90 100
IGDAAKNQVA MNPTQTIFDA KRLIGRKFDD AAVQSDMKHW PFEVVSADGK
110 120 130 140 150
PKIEVTYKDE KKTFFPEEIS SMVLTKMKET AEAYLGKTVT NAVITVPAYF
160 170 180 190 200
NDSQRQATKD AGTIAGLNVL RIINEPTAAA IAYGLDKKAV GERNVLIFDL
210 220 230 240 250
GGGTFDVSIL SIDDGIFEVK STAGDTHLGG EDFDNRLVTH FVQEFKRKHK
260 270 280 290 300
KDLTTNKRAL RRLRTACERA KRTLSSSTQA SIEIDSLFEG TDFYTSITRA
310 320 330 340 350
RFEELNADLF RSTMDPVEKA LRDAKLDKSV IHDIVLVGGS TRIPKVQRLL
360 370 380 390 400
QDLFNGKELN KSINPDEAVA YGAAVQAAIL HGDKSQEVQD LLLLDVTPLS
410 420 430 440 450
LGIETAGGVM SVLIKRNTTI PTKQTQTFTT YSDNQPGVLI QVYEGERAMT
460 470 480 490 500
KDNNLLGKFE LSGIPPAPRG VPQIEVTFDI DANGILNVTA LERSTNKENK
510 520 530 540 550
ITITNDKGRL SKEDIERMVN EAEKYRNEDE KQKETIAAKN GLESYCFNMK
560 570 580 590 600
ATLDEDNLKT KISDSDRTTI LDKCNETIKW LDANQLADKE EYEHRQKELE
610 620 630 640 650
GVCNPIITKL YQGAGFPPGG MPGGPGGMPG AAGAAGAAGA GGAGPTIEEV

D
Length:651
Mass (Da):71,131
Last modified:April 1, 1993 - v3
Checksum:i30F6BD7E07407B63
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti167L → P in AAA28627 (PubMed:2111451).Curated1
Sequence conflicti170L → P in AAA28627 (PubMed:2111451).Curated1
Sequence conflicti220K → Q in AAL89931 (PubMed:12537569).Curated1
Sequence conflicti360N → S in AAL89931 (PubMed:12537569).Curated1
Sequence conflicti625P → G in AAA28627 (PubMed:2111451).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01500 Genomic DNA Translation: AAB59186.1
M36114 Genomic DNA Translation: AAA28627.1
AE014297 Genomic DNA Translation: AAF55150.1
AE014297 Genomic DNA Translation: AAN13637.1
AE014297 Genomic DNA Translation: AAN13638.1
AE014297 Genomic DNA Translation: AAN13639.1
AE014297 Genomic DNA Translation: AAO41567.1
AE014297 Genomic DNA Translation: AAO41568.1
AY084193 mRNA Translation: AAL89931.1
BT023894 mRNA Translation: ABA81828.1
J02569 Genomic DNA Translation: AAA28631.1 Sequence problems.
PIRiA36333
RefSeqiNP_001262586.1, NM_001275657.1
NP_524356.1, NM_079632.6
NP_731987.1, NM_169625.2
NP_731988.1, NM_169626.2
NP_731989.1, NM_169627.2
NP_788679.1, NM_176502.2
NP_788680.1, NM_176503.2
UniGeneiDm.1206

Genome annotation databases

EnsemblMetazoaiFBtr0083055; FBpp0082514; FBgn0266599
FBtr0083056; FBpp0082515; FBgn0266599
FBtr0083057; FBpp0082516; FBgn0266599
FBtr0083058; FBpp0082517; FBgn0266599
FBtr0083059; FBpp0082518; FBgn0266599
FBtr0083060; FBpp0082519; FBgn0266599
FBtr0337053; FBpp0307982; FBgn0266599
GeneIDi41840
KEGGidme:Dmel_CG4264

Similar proteinsi

Entry informationi

Entry nameiHSP7D_DROME
AccessioniPrimary (citable) accession number: P11147
Secondary accession number(s): Q3KN45, Q8SXQ4, Q9VFB0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: April 1, 1993
Last modified: July 18, 2018
This is version 186 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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