Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Heat shock 70 kDa protein cognate 2

Gene

Hsc70-2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processStress response
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock 70 kDa protein cognate 2
Alternative name(s):
Heat shock 70 kDa protein 87D
Gene namesi
Name:Hsc70-2
Synonyms:Hsc2
ORF Names:CG7756
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0001217 Hsc70-2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000783391 – 633Heat shock 70 kDa protein cognate 2Add BLAST633

Proteomic databases

PaxDbiP11146
PRIDEiP11146

Expressioni

Developmental stagei

Heat shock cognate proteins are expressed constitutively during normal development.

Gene expression databases

BgeeiFBgn0001217
GenevisibleiP11146 DM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi66696, 10 interactors
IntActiP11146, 1 interactor
STRINGi7227.FBpp0082175

Structurei

3D structure databases

ProteinModelPortaliP11146
SMRiP11146
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP11146

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiKOG0101 Eukaryota
COG0443 LUCA
GeneTreeiENSGT00920000149416
InParanoidiP11146
KOiK03283
OMAiMDKKAIH
OrthoDBiEOG091G03SF
PhylomeDBiP11146

Family and domain databases

Gene3Di1.20.1270.10, 1 hit
2.60.34.10, 1 hit
InterProiView protein in InterPro
IPR018181 Heat_shock_70_CS
IPR029048 HSP70_C_sf
IPR029047 HSP70_peptide-bd_sf
IPR013126 Hsp_70_fam
PANTHERiPTHR19375 PTHR19375, 1 hit
PfamiView protein in Pfam
PF00012 HSP70, 1 hit
PRINTSiPR00301 HEATSHOCK70
SUPFAMiSSF100920 SSF100920, 1 hit
SSF100934 SSF100934, 1 hit
PROSITEiView protein in PROSITE
PS00297 HSP70_1, 1 hit
PS00329 HSP70_2, 1 hit
PS01036 HSP70_3, 1 hit

Sequencei

Sequence statusi: Complete.

P11146-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKIPAIGID LGTTYSCVGV WQNSKVEIIA NDQGNRTTPS YVAFNETERL
60 70 80 90 100
IGDPAKNQVA MNAKNTVFDA KRLIGRKFDD KKIQEDLKLW PFKVINEKGK
110 120 130 140 150
PKIEVEFKGE RKRFAPEEIS SMVLTKMREI AEVYLGGKVK DAVVTVPAYF
160 170 180 190 200
NDSQRQATKD AGSIAGLNVL RIINEPTAAA LAYGLDKNLK GERNVLIFDL
210 220 230 240 250
GGGTFDVSVL SIDEGSLFEV KATAGDTHLG GEDFDNRLVN HFAEEFKRKH
260 270 280 290 300
KSDIKGNARA LRRLRTACER AKRTLSSSTE ASLEIDALHE GIDFYSKISR
310 320 330 340 350
ARFEELNMDL FRSTMQPVER ALSDAKMDKK AIHDVVLVGG STRIPKIQKL
360 370 380 390 400
LQDLFGGKQL NLSINPDEAV AYGAAVQAAI LTGVGSSQIQ DLLLVDVAPL
410 420 430 440 450
SLGIETAGGV MTNLVERNAR IPCKQQQIFT TYSDNQNAVT IQVYEGERAM
460 470 480 490 500
TKDNNLLGTF NLTGIPPAPR GVPQIEVAFD LNADGILNVN AKDNSTGKSE
510 520 530 540 550
KITISNDKGR LSKAEIDRML SEAEKYKVED DRQRERVQSK NNLEAYIYAC
560 570 580 590 600
RQAVDDAPSG VLSETERSKV RDKCSSEASW LDKNSLAEKE EFESHLKECQ
610 620 630
RICTPIMSKI HGGKKGKSSM GKGSHPTVEE VDG
Length:633
Mass (Da):69,722
Last modified:February 21, 2001 - v2
Checksum:i851D3FBEDB227F08
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF54899.1
BT016141 mRNA Translation: AAV37026.1
K01297, K01296 Genomic DNA Translation: AAA28630.1
RefSeqiNP_524339.1, NM_079615.4
UniGeneiDm.2434

Genome annotation databases

EnsemblMetazoaiFBtr0082707; FBpp0082175; FBgn0001217
GeneIDi41609
KEGGidme:Dmel_CG7756

Similar proteinsi

Entry informationi

Entry nameiHSP7B_DROME
AccessioniPrimary (citable) accession number: P11146
Secondary accession number(s): Q5U0V1, Q9VFZ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: February 21, 2001
Last modified: June 20, 2018
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health